A pathological immunohistochemistry wet box

By designing an immunohistochemical wet box with adjustable glass structure and multifunctional lid, the problem of single function in the prior art is solved, the efficiency and quality of the experiment are improved, and more convenient experimental operations are achieved.

CN111505270BActive Publication Date: 2025-01-03江西省肿瘤医院(江西省第二人民医院 江西省癌症中心)
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Patent Information

Application Number
CN202010435283.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-05-21
Publication Date
2025-01-03
Estimated Expiration
2040-05-21

AI Technical Summary

Technical Problem

The existing immunohistochemical wet box has a single function during use and is inconvenient to use, resulting in poor experimental efficiency and quality.

Method used

A pathological immunohistochemical wet box is designed, which includes an adjustable glass slide structure, multiple connecting slots and support parts, liquid adding holes, drain ports and a cover for easy operation to ensure that the glass slide can be in the wet box. Perform rinsing, dyeing and other operations to improve the efficiency and quality of the experiment.

Benefits of technology

Through reasonable structural design, the direct operation of the slide in the wet box is achieved, which improves the efficiency and quality of the experiment and makes it more convenient to use.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention provides a pathological immunohistochemistry wet box, comprising a box body, which is hollow inside and opened upward, a front side wall of the box body is provided with a plurality of connecting grooves, the plurality of connecting grooves are arranged at equal intervals in the left and right directions, the connecting grooves are opened upward, a plurality of supporting parts are provided on the inner side of the rear side wall of the box body, the supporting parts are arranged corresponding to the connecting grooves, and also comprises a glass slide, the front end of the glass slide is connected to the supporting part, the rear end of the glass slide passes through the connecting groove and extends to the outside of the box body, a pressing block is also provided on the connecting groove, the pressing block is adaptively arranged with the connecting groove, the left and right sides of the pressing block are respectively provided with protruding sliding blocks, the left and right side walls of the connecting groove are respectively provided with sliding grooves corresponding to the sliding blocks, the sliding blocks and the sliding grooves form a sliding fit in the up and down directions, and also comprises a cover body, the cover body is covered at the upper end opening of the box body, a plurality of groups of liquid adding holes are provided on the cover body, each group of liquid adding holes is respectively arranged corresponding to a glass slide, and a drainage port connected to the interior thereof is provided at the bottom of the box body.
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Description

Technical Field

[0001] The invention relates to a pathological immunohistochemistry wet box. Background Art

[0002] Immunohistochemistry is the application of the basic principle of immunology - antigen-antibody reaction, that is, the principle of specific binding of antigen and antibody. It uses chemical reaction to make the color developer (fluorescein, enzyme, metal ion, isotope) labeled with antibody develop color to determine the antigen (peptide and protein) in tissue cells, and conduct localization, qualitative and relative quantitative research on it. This is called immunohistochemistry or immunocytochemistry.

[0003] When doing immunohistochemical experiments, immunohistochemical humidified boxes are often used. Among them, there are various types of immunohistochemical humidified boxes in the prior art. However, in actual use, the existing immunohistochemical humidified boxes generally have some inconveniences such as relatively single functions. Summary of the invention

[0004] In view of the problems pointed out in the background technology, the present invention proposes a pathological immunohistochemistry wet box, which has a reasonable structural design, is easy to use, is conducive to the conduct of experiments, and is conducive to improving the efficiency and quality of experiments.

[0005] The technical solution of the present invention is achieved in this way:

[0006] A pathological immunohistochemistry wet box comprises a box body, wherein the box body is hollow inside and is opened upward, a plurality of connecting grooves are arranged on the front side wall of the box body, and the plurality of connecting grooves are arranged at equal intervals in the left and right directions, and the connecting grooves are opened upward, a plurality of supporting parts are arranged on the inner side of the rear side wall of the box body, and the supporting parts are arranged corresponding to the connecting grooves, and also comprises a glass slide, the front end of the glass slide is connected to the supporting part, and the rear end of the glass slide passes through the connecting groove and extends to the outside of the box body, and a pressing block is also arranged on the connecting groove, and the pressing block is adapted to the connecting groove, and protruding sliders are respectively arranged on the left and right sides of the pressing block, and slide grooves corresponding to the sliders are respectively arranged on the left and right side walls of the connecting groove, and the sliders and the slide grooves form a sliding fit in the up and down directions, and also comprises a cover body, and the cover body is covered at the upper end opening of the box body, and a plurality of groups of liquid adding holes are arranged on the cover body, and each group of liquid adding holes is arranged corresponding to a glass slide, and a drainage port connected to the interior of the box body is provided at the bottom of the box body.

[0007] The present invention is further configured such that the supporting portion includes a first supporting portion, a second supporting portion, and a third supporting portion, the second supporting portion is arranged at the lower side of the first supporting portion, the third supporting portion is arranged at the lower side of the second supporting portion, the second supporting portion protrudes forward from the first supporting portion, the third supporting portion protrudes forward from the second supporting portion, and the first supporting portion is arranged at the same height as the bottom of the connecting groove.

[0008] The present invention is further configured such that a positioning protrusion is provided at the front end of the glass slide, a positioning groove cooperating with the positioning protrusion is provided on the second supporting part and the third supporting part respectively, a positioning groove cooperating with the positioning protrusion is provided on the inner side of the rear side wall of the box body, and the positioning groove is arranged corresponding to the positioning protrusion.

[0009] The present invention is further configured such that each group of liquid adding holes includes a plurality of liquid adding holes, and the plurality of liquid adding holes are arranged at intervals along the front-to-back direction on the cover body.

[0010] The present invention is further configured such that the pressing block is provided with a hand-held operating portion extending toward the front side of the box body.

[0011] The present invention is further configured such that the cover body is opened at the lower side and the front side.

[0012] The present invention is further configured such that a sticky note sticking area is provided on the lower side surface of the rear end of the glass slide, and a circle of liquid separation grooves is provided on the glass slide surrounding the sticky note sticking area.

[0013] The present invention is further configured such that a drainage pipe is connected to the drainage port, and a detachable sealing plug is provided at the outlet of the drainage pipe.

[0014] The present invention is further configured such that the bottom surface of the inner side of the box body is an inclined surface inclined toward the liquid discharge port.

[0015] The present invention is further configured such that the box body is provided with a plurality of patches for covering the liquid adding holes, the patches are arranged corresponding to each group of liquid adding holes, the patches are in the shape of long strips, one end of the patches is fixedly connected to the cover body, and the other end of the patches is a free end.

[0016] By adopting the above technical solution, the beneficial effects of the present invention are as follows:

[0017] The pathological immunohistochemistry wet box provided by the present invention is provided with a structure on which a glass slide can be directly placed, so that operations such as washing and staining of tissues on the glass slide can be directly performed in the wet box. The structure is reasonably designed, easy to use, and is conducive to the conduct of experiments and to improving the efficiency and quality of experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0019] Figure 1 It is a structural schematic diagram of the present invention;

[0020] Figure 2 It is a schematic diagram of the decomposition of the present invention;

[0021] Figure 3 The structure of the hidden cover of the present invention is shown in FIG. Figure 1 ;

[0022] Figure 4 The structure of the hidden cover of the present invention is shown in FIG. Figure 2 ;

[0023] Figure 5 The decomposition diagram of the present invention is shown in FIG. Figure 2 ;

[0024] Figure 6 It is a structural schematic diagram of the cover body of the present invention;

[0025] Figure 7 It is a structural schematic diagram of the glass slide of the present invention;

[0026] Figure 8 For the present invention Figure 5 A magnified view of part A;

[0027] Fig. 9 It is a schematic diagram of the structure of the briquette of the present invention;

[0028] Fig.10 For the present invention Figure 5 Enlarged view of part B. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] For reference Figure 1-10 The present invention is described:

[0031] A pathological immunohistochemical wet box comprises a box body 1, wherein the box body 1 is hollow inside and opened upward.

[0032] A plurality of connection slots 2 are arranged on the front side wall of the box body 1. The plurality of connection slots 2 are arranged at equal intervals in the left-right direction, and the connection slots 2 are opened upward.

[0033] A plurality of supporting parts 3 are disposed on the inner side of the rear side wall of the box body 1 , and the supporting parts 3 are disposed correspondingly to the connecting grooves 2 (the quantity and positions are disposed correspondingly).

[0034] It also includes a glass slide 4, which is in a long strip shape. The front end of the glass slide 4 is connected to the supporting portion 3 (resting on the supporting portion), and the rear end of the glass slide 4 passes through the connecting groove 2 and extends to the outside of the box body 1.

[0035] The connecting groove 2 is also provided with a pressing block 5, which is adapted to the connecting groove 2. The left and right sides of the pressing block 5 are respectively provided with protruding sliding blocks 6. The left and right side walls of the connecting groove 2 are respectively provided with sliding grooves 7 corresponding to the sliding blocks 6. The sliding blocks 6 and the sliding grooves 7 form a sliding fit in the up and down directions. The pressing block 5 is used to press the glass slide 4 to fix the glass slide 4.

[0036] The box body 1 also includes a cover 8, which is covered at the upper opening of the box body 1. The cover 8 is made of light-proof material and can block light to prevent light from entering the box. The cover 8 is provided with a plurality of groups of liquid adding holes 9, each group of liquid adding holes 9 corresponding to a glass slide 4. Reagents are added to the glass slide 4 and the glass slide is rinsed through the liquid adding holes 9.

[0037] The bottom of the box body 1 is provided with a drain port 10 communicating with the interior thereof, through which the waste liquid remaining in the box body can be discharged.

[0038] The supporting part 3 includes a first supporting part 31, a second supporting part 32, and a third supporting part 33. The second supporting part 32 is arranged at the lower side of the first supporting part 31, and the third supporting part 33 is arranged at the lower side of the second supporting part 32. The second supporting part 32 protrudes forward from the first supporting part 31, and the third supporting part 33 protrudes forward from the second supporting part 32. The first supporting part 31 is arranged at the same height as the bottom of the connecting groove 2. The three-level supporting part structure design allows the placement position of the glass slide to be adjusted, and the glass slide can be adjusted to be placed at an angle, which is convenient for the experimenter to adjust and use according to needs.

[0039] The front end of the glass slide 4 is provided with a positioning protrusion 11, and the second supporting portion 32 and the third supporting portion 33 are respectively provided with a positioning groove 12 that matches the positioning protrusion 11, and the inner side of the rear side wall of the box body 1 is provided with a positioning groove 12 that matches the positioning protrusion 11, and the positioning groove 12 is arranged corresponding to the positioning protrusion 11. The positioning protrusion 11 cooperates with the positioning groove 12 to locate the position of the front end of the glass slide to prevent the glass slide from moving.

[0040] Each group of liquid adding holes 9 includes a plurality of liquid adding holes 9 , and the plurality of liquid adding holes 9 are arranged at intervals along the front-to-back direction on the cover body 8 .

[0041] The pressing block 5 is provided with a hand-held operating portion 13 extending toward the front side of the box body 1 , and the pressing block 5 can be conveniently moved through the hand-held operating portion 13 .

[0042] Wherein, the cover body 8 is opened at the bottom and front.

[0043] A sticky note area 14 is provided on the lower side surface of the rear end of the glass slide 4, and a circle of liquid separation grooves 15 are provided on the glass slide 4 around the sticky note area 14. The liquid separation grooves 15 can contain the sticky note to prevent liquid from contacting the sticky note.

[0044] The drainage port 10 is connected to a drainage pipe 16 , and a detachable sealing plug is provided at the outlet of the drainage pipe 16 .

[0045] The bottom surface of the inner side of the box body 1 is an inclined surface inclined toward the liquid discharge port 10, so as to facilitate the discharge of residual liquid in the box body.

[0046] The box body 1 is provided with a plurality of patches 18 for covering the liquid adding holes 9. The patches 18 are arranged corresponding to each group of liquid adding holes 9. The patches 18 are long strips. One end of the patches 18 is fixedly connected to the cover body 8, and the other end of the patches 18 is a free end. The patches 18 are transparent. The patches 18 are attached to the box body to close the liquid adding holes. When adding medicine is needed, the patches are lifted up. The patches 18 are made of light-proof material.

[0047] By adopting the above technical solution, the beneficial effects of the present invention are as follows:

[0048] The pathological immunohistochemistry wet box provided by the present invention is provided with a structure on which a glass slide 4 can be directly placed, so that operations such as washing and staining of the tissue on the glass slide 4 can be directly performed in the wet box. The structure is reasonably designed and easy to use, which is conducive to the conduct of the experiment and helps to improve the efficiency and quality of the experiment.

[0049] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A pathological immunohistochemistry wet box, characterized in that: The box body comprises a box body, which is hollow inside and opened upward, a plurality of connecting grooves are arranged on the front side wall of the box body, and the plurality of connecting grooves are arranged at equal intervals in the left and right directions, and the connecting grooves are opened upward, a plurality of supporting parts are arranged on the inner side of the rear side wall of the box body, and the supporting parts are arranged corresponding to the connecting grooves, and also comprises a glass slide, the front end of the glass slide is connected to the supporting part, and the rear end of the glass slide passes through the connecting groove and extends to the outside of the box body, and a pressing block is also provided on the connecting groove, and the pressing block is adapted to the connecting groove, and protruding sliders are respectively provided on the left and right sides of the pressing block, and sliding grooves corresponding to the sliding grooves are respectively provided on the left and right side walls of the connecting groove, and the sliding grooves form a sliding fit with the sliding grooves in the up and down directions, and also comprises a cover body, the cover body is covered at the upper end opening of the box body, and the cover body is provided with a plurality of groups of liquid adding holes , each group of liquid adding holes is respectively arranged corresponding to a glass slide, and the bottom of the box body is provided with a drainage port connected to the interior thereof; the supporting part comprises a first supporting part, a second supporting part, and a third supporting part, the second supporting part is arranged at the lower side of the first supporting part, the third supporting part is arranged at the lower side of the second supporting part, the second supporting part protrudes forward from the first supporting part, the third supporting part protrudes forward from the second supporting part, and the first supporting part is arranged at the same height as the bottom of the connecting groove; a positioning protrusion is provided at the front end of the glass slide, and a positioning groove cooperating with the positioning protrusion is respectively provided on the second supporting part and the third supporting part, and a positioning groove cooperating with the positioning protrusion is provided on the inner side of the rear side wall of the box body, and the positioning groove is arranged corresponding to the positioning protrusion; each group of liquid adding holes comprises a plurality of liquid adding holes, and the plurality of liquid adding holes are arranged at intervals along the front-to-back direction on the cover body.

2. A pathological immunohistochemistry wet box according to claim 1, characterized in that: The pressing block is provided with a hand-held operating portion extending toward the front side of the box body.

3. A pathological immunohistochemistry wet box according to claim 2, characterized in that: The cover body is arranged with openings at the lower side and the front side.

4. A pathological immunohistochemistry wet box according to claim 1, characterized in that: A sticky note sticking area is arranged on the lower side surface of the rear end of the glass slide, and a circle of liquid separation grooves is arranged on the glass slide around the sticky note sticking area.

5. A pathological immunohistochemistry wet box according to claim 1, characterized in that: The drainage port is connected with a drainage pipe, and the outlet of the drainage pipe is provided with a detachable sealing plug.

6. A pathological immunohistochemistry wet box according to claim 5, characterized in that: The bottom surface of the inner side of the box body is an inclined surface inclined toward the liquid discharge port.

7. A pathological immunohistochemistry wet box according to claim 1, characterized in that: The box body is provided with a plurality of patches for covering the liquid adding holes, the patches are arranged corresponding to each group of liquid adding holes, the patches are in the shape of long strips, one end of the patches is fixedly connected to the cover body, and the other end of the patches is a free end.