Spray for treating toothache and preparation method thereof

Abstract

The invention discloses a spray for treating toothache and a preparation method thereof, and belongs to the field of dental analgesic sprays. The spray does not contain any unnatural additive, reducesoral irritation for protecting the oral mucosa, prolongs the retention time of a drug in the oral cavity, inhibits enzymes, improves the bioavailability of the drug, and contributes to pharmaceutics.The natural aroma of plant essence oil with the aroma therapy effect is actively utilized to stimulate the oral cells to pass through the brain to achieve the effects of regulating mood, balancing immunity and assisting the drug in overall treatment. In addition, the purpose of improving the chemical and biological stability of a medicament in the storage period is achieved by means of the form of the spray.

Description

technical field

[0001] The invention relates to the field of dental pain-relieving sprays, in particular to a spray for treating dental pain and a preparation method thereof. Background technique

[0002] Toothache is one of the most common symptoms of oral diseases, which seriously plagues most people's daily life. There are many causes of toothache, such as dental caries, pulpitis, periapical inflammation, dentin hypersensitivity, tooth decay or fractured teeth leading to pulp (dental nerve) infection. The medicine for the treatment of toothache at present mainly has effects such as antipyretic, antibacterial, analgesic. Common internal medicines include Compound Yatong Tincture, Yazhoukang, Wantongyankang Tablets or Niuhuangjiedu Pills, etc. Although these medicines have certain therapeutic effects, they cannot solve the problem quickly. It takes hours to have a gradual effect. This process needs to endure pain, and it may increase inflammation and prolong the disease p...

Examples

Embodiment 1

[0023] refer to figure 1 Carry out the preparation of spray according to process 1: take by weighing medicinal materials: 3 parts of flying dragonfly, 5 parts of cinnabar root, 8 parts of Asarum, 12 parts of cocklebur and 8 parts of medlar, add 8 times the amount of 30% ethanol, reflux 1h, pour out the medicinal solution, add 6 times the amount of 30% ethanol, reflux for 1h, combine the medicinal solutions, recover ethanol under reduced pressure, and continue to concentrate the medicinal solution, which is marked as process 1;

Embodiment 2

[0025] refer to figure 1 Carry out the preparation of spray according to process 2: take by weighing medicinal materials: 3 parts of flying dragonfly, 5 parts of cinnabar root, 8 parts of asarum, 12 parts of cocklebur and 8 parts of medlar, add 8 times of 60% ethanol, reflux 1h, pour out the medicinal solution, add 6 times the amount of 60% ethanol, reflux for 1h, combine the medicinal solutions, recover ethanol under reduced pressure, and continue to concentrate the medicinal solution, which is marked as process 2;

Embodiment 3

[0027] refer to figure 1 Carry out the preparation of spray according to process 3: take by weighing medicinal materials: take by weighing medicinal materials: 3 parts of flying dragonfly, 5 parts of cinnabar root, 8 parts of Asarum, 12 parts of cocklebur and 8 parts of medlar, add 10 times of water , extract the volatile oil by steam distillation for 7 hours, filter the mother liquor, add 6 times the amount of water to the dregs, decoct for 1 hour, filter, combine the medicinal solution, centrifuge, concentrate the supernatant under reduced pressure to a density of 1.05g / mL, add 95% ethanol to make the ethanol content in the medicinal solution reach 60%, let it stand for 12 hours, filter with suction, recover ethanol, solubilize the volatile oil with Tween-80, mix it evenly with the medicinal solution, set the volume to 150mL, and mark it as process 3;

technical field

[0001] The invention relates to the field of dental pain-relieving sprays, in particular to a spray for treating dental pain and a preparation method thereof. Background technique

[0002] Toothache is one of the most common symptoms of oral diseases, which seriously plagues most people's daily life. There are many causes of toothache, such as dental caries, pulpitis, periapical inflammation, dentin hypersensitivity, tooth decay or fractured teeth leading to pulp (dental nerve) infection. The medicine for the treatment of toothache at present mainly has effects such as antipyretic, antibacterial, analgesic. Common internal medicines include Compound Yatong Tincture, Yazhoukang, Wantongyankang Tablets or Niuhuangjiedu Pills, etc. Although these medicines have certain therapeutic effects, they cannot solve the problem quickly. It takes hours to have a gradual effect. This process needs to endure pain, and it may increase inflammation and prolong the disease p...

Examples

Embodiment 1

[0023] refer to figure 1 Carry out the preparation of spray according to process 1: take by weighing medicinal materials: 3 parts of flying dragonfly, 5 parts of cinnabar root, 8 parts of Asarum, 12 parts of cocklebur and 8 parts of medlar, add 8 times the amount of 30% ethanol, reflux 1h, pour out the medicinal solution, add 6 times the amount of 30% ethanol, reflux for 1h, combine the medicinal solutions, recover ethanol under reduced pressure, and continue to concentrate the medicinal solution, which is marked as process 1;

Embodiment 2

[0025] refer to figure 1 Carry out the preparation of spray according to process 2: take by weighing medicinal materials: 3 parts of flying dragonfly, 5 parts of cinnabar root, 8 parts of asarum, 12 parts of cocklebur and 8 parts of medlar, add 8 times of 60% ethanol, reflux 1h, pour out the medicinal solution, add 6 times the amount of 60% ethanol, reflux for 1h, combine the medicinal solutions, recover ethanol under reduced pressure, and continue to concentrate the medicinal solution, which is marked as process 2;

Embodiment 3

[0027] refer to figure 1 Carry out the preparation of spray according to process 3: take by weighing medicinal materials: take by weighing medicinal materials: 3 parts of flying dragonfly, 5 parts of cinnabar root, 8 parts of Asarum, 12 parts of cocklebur and 8 parts of medlar, add 10 times of water , extract the volatile oil by steam distillation for 7 hours, filter the mother liquor, add 6 times the amount of water to the dregs, decoct for 1 hour, filter, combine the medicinal solution, centrifuge, concentrate the supernatant under reduced pressure to a density of 1.05g / mL, add 95% ethanol to make the ethanol content in the medicinal solution reach 60%, let it stand for 12 hours, filter with suction, recover ethanol, solubilize the volatile oil with Tween-80, mix it evenly with the medicinal solution, set the volume to 150mL, and mark it as process 3;

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