A production line for sterilizing hollow capsules using ethylene oxide

By designing a production line including a conveying mechanism and a capsule packaging box, and using the inflatable mechanism to fill ethylene oxide gas in the packaging box, the problems of ethylene oxide gas leakage and low production efficiency are solved, and workers' safety and production efficiency are improved.

CN111634496BActive Publication Date: 2025-03-14ZHEJIANG ANGLIKANG CAPSULE
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Patent Information

Application Number
CN202010616812.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-07-01
Publication Date
2025-03-14
Estimated Expiration
2040-07-01

AI Technical Summary

Technical Problem

The prior art causes ethylene oxide gas to leak into the environment when filled with ethylene oxide gas into the hollow capsule packaging bag, which endangers the health of production workers and is inefficient in production efficiency.

Method used

A production line including a conveying mechanism and a capsule packaging box was designed. The ethylene oxide gas is charged in the capsule packaging box through the inflatable mechanism, and the gas is controlled and filled with injection needles and ventilation pipes to ensure that the gas is charged in the packaging box and reduce leakage.

Benefits of technology

Effectively prevent ethylene oxide gas from leaking into the working environment, improve the safety of production workers, and improve production efficiency through batch inflation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention discloses a production line for sterilizing hollow capsules with ethylene oxide, including a conveying mechanism, a packaging box delivery mechanism and a capsule packaging box, a strapping machine is arranged on the side of the packaging box delivery mechanism away from the conveying mechanism, a bracket is arranged at the end of the conveying mechanism, a carton positioning mechanism is arranged on the lower surface of the bracket, an inflation mechanism is arranged on one side of the conveying mechanism, the inflation mechanism includes a moving plate, a pushing component and a plurality of inflation components, and an air supply mechanism is arranged on one side of the inflation mechanism. The present invention can complete the transportation of capsule packaging boxes and fill ethylene oxide gas into the packaging bags of hollow capsules in the capsule packaging boxes, push the packaging boxes to the packaging box delivery mechanism after inflation is completed, and tie the capsule packaging boxes with a strapping machine. During the production process, ethylene oxide gas can be prevented from leaking from the packaging bags into the working environment to cause damage to production personnel, and the packaging bags can be inflated in batches to improve production efficiency.
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Description

Technical Field

[0001] The invention relates to the technical field of capsule production, and in particular to a production line for sterilizing hollow capsules with ethylene oxide. Background Art

[0002] Ethylene oxide is an organic compound with the chemical formula C2H4O. It is a toxic carcinogen and was previously used to make fungicides. Ethylene oxide is flammable and explosive and difficult to transport over long distances, so it has a strong regionality. It is widely used in the washing, pharmaceutical, printing and dyeing industries. When the hollow capsules are finally packed, a certain amount of ethylene oxide gas needs to be filled into the packaging bag to sterilize the hollow capsules.

[0003] In the actual production process of the prior art, the packaging bag is manually held, and then an inflation tube is inserted into the packaging bag to evacuate it, and then ethylene oxide gas is filled into it. After the filling is completed, it is plastic-sealed to prevent the rapid leakage of ethylene oxide gas. However, during the inflation process, ethylene oxide gas will leak into the environment from the open gap at the upper end of the packaging bag, and the production workers who hold the packaging bag are in such an environment for a long time, and will inevitably inhale some ethylene oxide gas. Ethylene oxide is a central nervous system depressant, irritant and protoplasmic poison. Production workers working in such an environment for a long time will cause damage to their bodies. In addition, in order to control the amount of ethylene oxide gas leaking from the packaging bag into the environment, batch inflation cannot be carried out simultaneously in the same environment, resulting in low production efficiency. Summary of the invention

[0004] The purpose of the present invention is to provide a packaging bag capable of filling ethylene oxide gas into hollow capsules, and at the same time, during the filling process, the ethylene oxide gas can be prevented from leaking from the packaging bag into the working environment to cause damage to production personnel, and the packaging bags can be filled in batches to improve production efficiency.

[0005] The above technical objectives of the present invention are achieved through the following technical solutions: a production line for sterilizing hollow capsules with ethylene oxide, comprising a conveying mechanism and a capsule packaging box located on the conveying mechanism for conveying, a bracket is arranged at the end of the conveying mechanism, the bracket comprises a top plate, the top plate is located directly above the conveying mechanism, a carton positioning mechanism is arranged on the lower surface of the top plate, an inflation mechanism is arranged on one side of the conveying mechanism, the inflation mechanism is located on the rear side of the bracket, the inflation mechanism comprises a moving plate, a pushing component for driving the moving plate to move, and a plurality of inflation components arranged on the upper surface of the moving plate The inflation component comprises an injection needle, the diameter of the injection needle is 1.5-2 mm, an air supply mechanism is arranged on one side of the inflation mechanism, a plurality of injection holes are opened on the side wall of the capsule packaging box close to the inflation mechanism, a rubber ring is arranged on the injection hole, the inner walls of the rubber ring are pressed against each other toward the center position, a plurality of partitions are arranged vertically at intervals inside the capsule packaging box, the partitions divide the capsule packaging box into a plurality of storage cavities, a hollow capsule packaging bag is placed in the storage cavity, and the side of the hollow capsule packaging bag close to the inflation mechanism is closely attached to the inner wall of the capsule packaging box.

[0006] Through the above technical solution, the capsule packaging box is transported to the inflation mechanism through the conveying mechanism, and the capsule packaging box is positioned by the carton positioning mechanism, and several inflation components simultaneously fill several hollow capsule packaging bags in the capsule packaging box with ethylene oxide gas. No manual control is required in this process, which prevents excessive contact between production workers and ethylene oxide gas and ensures a safe operating distance for production workers. Moreover, the inflation process is carried out in the capsule packaging box, which reduces the amount of ethylene oxide gas diffused into the air and improves production safety. In addition, multiple bags of hollow capsule packaging bags in the capsule packaging box can be filled with ethylene oxide at the same time, which improves production efficiency.

[0007] The present invention is further configured as follows: two vertical clamping strips are arranged on the inner wall of the storage cavity close to the inflation mechanism, and the two clamping strips are respectively located on both sides of the injection hole; two strip-shaped clamping blocks are arranged on the hollow capsule packaging bag, and the two strip-shaped clamping blocks are slidably inserted in the two clamping strips.

[0008] Through the above technical solution, the side wall of the hollow capsule packaging bag can be fixed to one side of the injection hole, so that the injection needle can be inserted from the injection hole to pierce the side wall of the hollow capsule packaging bag and enter the interior of the hollow capsule packaging bag for inflation.

[0009] The present invention is further configured as follows: the end of the injection needle is hemispherical and sealed, and a plurality of gas passage holes are provided on the side wall of the injection needle near the end.

[0010] Through the above technical solution, the end of the injection needle is hemispherical, which can prevent the hollow capsules in the hollow capsule packaging bag from being damaged when the injection needle is inserted into the hollow capsule packaging bag.

[0011] The present invention is further configured as follows: the two carton positioning mechanisms are respectively located at diagonally opposite positions on the lower surface of the top plate, the carton positioning mechanism includes a cylinder 1, a connecting block 1 and an L-shaped positioning plate, the connecting block 1 is fixedly connected to the piston rod of the cylinder 1, and the L-shaped positioning plate is fixedly connected to the lower surface of the connecting block 1.

[0012] Through the above technical scheme, by starting cylinder one, the L-shaped positioning plates located at the diagonal corners of the capsule packaging box are driven to move toward the direction of the capsule packaging box at the same time. When the piston rod of cylinder one is completely retracted into the cylinder body of cylinder one, the inner walls of the L-shaped positioning plates on the diagonal sides of the capsule packaging box are just in close contact with the outer walls of the capsule packaging box, and the capsule packaging box is moved to just below the top plate, completing the positioning of the capsule packaging box, so that the injection needle from the air mechanism can be aligned with the injection hole on the capsule packaging box.

[0013] The present invention is further configured as follows: the pushing assembly includes a fixed base and a second cylinder, a plurality of inflatable tracks are arranged in parallel on the upper surface of the fixed base, the lower end of the movable plate is slidably connected to the inflatable tracks, the second cylinder is arranged on the upper surface of the fixed base and is located on the side of the movable plate away from the conveying mechanism, and the piston rod of the second cylinder is fixedly connected to the side wall of the movable plate.

[0014] Through the above technical solution, the control cylinder 2 can drive the movable plate to move towards and away from the capsule packaging box on the inflation track.

[0015] The present invention is further configured as follows: the inflation component also includes an inflation fixing frame, an inflation pump and an air extraction pump fixed on the inflation fixing frame, and a ventilation tube fixed in the middle of the bracket, one end of the ventilation tube is connected to the injection needle, and a three-way pipe fitting is arranged between the ventilation tube, the inflation pump and the air extraction pump.

[0016] Through the above technical solution, the hollow capsule packaging bag can be directly filled with ethylene oxide gas after the injection needle completes evacuating the air.

[0017] The present invention is further configured as follows: a first solenoid valve is provided between the three-way pipe fitting and the inflation pump, and a second solenoid valve is provided between the three-way pipe fitting and the air extraction pump.

[0018] Through the above technical solution, it is convenient to control the vacuuming and filling of ethylene oxide gas into the hollow capsule packaging bag, and set the time of vacuuming and filling.

[0019] The present invention is further configured as follows: the gas supply mechanism includes an ethylene oxide gas cylinder and a gas storage tank, an air supply pipe is connected between the ethylene oxide gas cylinder and the gas storage tank, an air supply pipe is connected between the gas outlet of the gas storage tank and the air pump, and an electromagnetic valve three is arranged on the air supply pipe.

[0020] The above technical solution makes it convenient for production personnel to control the ethylene oxide gas supply. When problems occur in production, the supply of ethylene oxide gas can be shut down in time, thereby improving the overall safety of the device.

[0021] The present invention is further configured as follows: a pushing mechanism is provided on the side of the conveying mechanism close to the inflation mechanism, the pushing mechanism includes a long-stroke cylinder and a push plate, a cylinder mounting frame is provided on one side of the conveying mechanism, the long-stroke cylinder is fixedly connected to the upper end of the cylinder mounting frame, the piston rod of the long-stroke cylinder faces the conveying mechanism, and the push plate and the piston rod of the long-stroke cylinder are fixedly connected.

[0022] Through the above technical solution, the piston rod of the long-stroke cylinder is controlled to be pushed outward so that the push plate can push the capsule packaging box to the side of the packaging box delivery mechanism. After the filling is completed, the pushing mechanism pushes the capsule packaging box to the packaging box delivery mechanism and transmits it to the next production process position through the packaging box delivery mechanism.

[0023] The present invention is further configured as follows: a blocking plate is provided on the lower surface of the left side of the top plate, a detection hole is opened at the center of the blocking plate, and a reflective photoelectric switch is provided in the detection hole.

[0024] Through the above technical solution, when the conveying mechanism conveys the capsule packaging box to the bottom of the top plate, the reflective photoelectric switch can detect the capsule packaging box and control the conveying mechanism to stop conveying the capsule packaging box. After the inflation mechanism completes the inflation of the hollow capsule packaging bag in the capsule packaging box, the capsule packaging box is pushed to the packaging box passing mechanism. At this time, the reflective photoelectric switch detects that there is no capsule packaging box under the top plate, and controls the conveying mechanism to continue conveying and transport the next capsule packaging box to the bottom of the top plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 The structure of the present invention is schematically shown Figure 1 ;

[0026] Figure 2 The structure of the present invention is schematically shown Figure 2 ;

[0027] Figure 3 For the present invention Figure 2 A schematic diagram of the enlarged structure of the middle A part;

[0028] Figure 4This is a schematic diagram of the internal structure of the capsule packaging box of the present invention;

[0029] Figure 5 For the present invention Figure 3 A schematic diagram of the enlarged structure of the middle B part;

[0030] Figure 6 The structure of the present invention is schematically shown Figure 3 .

[0031] Meanings of the numbers in the figure: 1. Conveying mechanism; 2. Capsule packaging box; 3. Bracket; 4. Top plate; 5. Carton positioning mechanism; 6. Inflating mechanism; 7. Moving plate; 8. Pushing assembly; 9. Inflating assembly; 10. Injection needle; 11. Air supply mechanism; 12. Injection plug hole; 13. Rubber ring; 14. Partition; 15. Storage cavity; 16. Empty capsule packaging bag; 17. Card strip; 18. Bar card block; 19. Gas passage hole; 20. Cylinder 1; 21. Connecting block 1; 22. L-shaped positioning plate; 23. Fixed base; 24. Gas Cylinder 2; 25. Inflating track; 26. Packing box delivery mechanism; 27. Inflating pump; 28. Air extraction pump; 29. ​​Ventilation pipe; 30. Three-way pipe fitting; 31. Solenoid valve 1; 32. Solenoid valve 2; 33. Ethylene oxide cylinder; 34. Gas storage tank; 35. Gas transmission pipe; 36. Gas delivery pipe; 37. Solenoid valve 3; 38. Push mechanism; 39. Long-stroke cylinder; 40. Push plate; 41. Cylinder mounting bracket; 42. Blocking plate; 43. Detection hole; 44. Reflective photoelectric switch; 45. Hanging rod; 46. Air extraction pipe; 47. Inflating pipe. DETAILED DESCRIPTION

[0032] The specific implementation of the present invention is further described in detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0033] The following references Figures 1 to 6 The present invention will be described.

[0034] Embodiment 1:

[0035] A production line for sterilizing hollow capsules with ethylene oxide, comprising a conveying mechanism 1 and a capsule packaging box 2 for conveying on the conveying mechanism 1, an air filling mechanism 6 and a pushing mechanism 38 are arranged on one side of the end of the conveying mechanism 1, a packaging box delivery mechanism 26 is arranged on the other side of the end of the conveying mechanism 1, and a strapping machine is arranged on the side of the packaging box delivery mechanism 26 away from the conveying mechanism. The air filling mechanism 6 can fill the capsule packaging box 2 transported to the end of the conveying mechanism 1 with ethylene oxide gas. The pushing mechanism 38 comprises a long-stroke cylinder 39 and a push plate 40, a cylinder mounting frame 41 is arranged on one side of the conveying mechanism 1, the long-stroke cylinder 39 is fixedly connected to the upper end of the cylinder mounting frame 41, the piston rod of the long-stroke cylinder 39 faces the conveying mechanism 1, the push plate 40 is fixedly connected to the piston rod of the long-stroke cylinder 39, and the piston rod of the long-stroke cylinder 39 is controlled to be pushed outward so that the push plate 40 can push the capsule packaging box 2 to the side of the packaging box delivery mechanism 26. After the filling is completed, the capsule packaging box 2 is pushed by the pushing mechanism 38 to the packaging box outfeeding mechanism 26 and is transferred to the next production process position through the packaging box outfeeding mechanism 26.

[0036] A plurality of injection holes 12 are provided on the side wall of the capsule packaging box 2 near the inflation mechanism 6. In this embodiment, the injection holes 12 are circular in shape, and the diameter of the injection holes 12 is 3-5 mm. A rubber ring 13 is provided on the inner wall of the injection hole 12, and an embedding groove is provided on the outer wall of the rubber ring 13. The inner wall of the injection hole 12 is embedded in the embedding groove, and the rubber ring 13 and the capsule packaging box 2 are fixedly connected by glue. The inner walls of the rubber ring 13 are pressed against each other toward the center position, so that the gas in the capsule packaging box 2 cannot pass through the hole in the middle of the rubber ring 13. The rubber ring 13 prevents the ethylene oxide gas in the capsule packaging box 2 from quickly overflowing from the injection hole 12 into the environment.

[0037] A plurality of partitions 14 are arranged vertically at intervals inside the capsule packaging box 2. The partitions 14 divide the capsule packaging box 2 into a plurality of storage cavities 15. The storage cavities 15 are neatly arranged along the length direction of the capsule packaging box 2, and each storage cavity 15 has an injection hole 12 at the center position on the side wall near the inflation mechanism 6. A hollow capsule packaging bag 16 is placed in the storage cavity 15, and the side of the hollow capsule packaging bag 16 near the inflation mechanism 6 is closely attached to the inner wall of the capsule packaging box 2. Two vertical clamping strips 17 are arranged on the inner wall of the storage cavity 15 near the inflation mechanism 6. The two clamping strips 17 are respectively located on both sides of the injection hole 12, and the clamping strips 17 are fixedly connected to the inner wall of the capsule packaging box 2. Two strip-shaped clamping blocks 18 are arranged on the hollow capsule packaging bag 16. The two strip-shaped clamping blocks 18 are slidably inserted in the two clamping strips 17, and the part of the hollow capsule packaging bag 16 located between the two strip-shaped clamping blocks 18 is straightened and located on the side near the inflation mechanism 6.

[0038] A support 3 is provided at the end of the conveying mechanism 1. The support 3 includes a top plate 4 and four suspension rods 45. The four suspension rods 45 are vertically arranged and the lower ends of the four suspension rods 45 are fixedly connected to the four corner positions of the upper end of the top plate 4. The upper ends of the suspension rods 45 are fixedly connected to the top of the site. The top plate 4 is located directly above the conveying mechanism 1. A blocking plate 42 is provided on the lower surface of the left side of the top plate 4. The blocking plate 42 is vertically arranged and the upper end of the blocking plate 42 is fixedly connected to the position of the left edge of the lower surface of the top plate 4 by screws. A detection hole 43 is provided at the center of the blocking plate 42. The shape of the detection hole in this embodiment is circular. A reflective photoelectric switch 44 is provided in the detection hole 43. The reflective photoelectric switch 44 uses the object to block or reflect the infrared light beam, and is selected by the synchronization circuit to detect the presence or absence of the object. When the conveying mechanism 1 conveys the capsule packaging box 2 to the bottom of the top plate 4, the reflective photoelectric switch 44 can detect the capsule packaging box 2 and control the conveying mechanism 1 to stop conveying the capsule packaging box 2. After the inflation mechanism 6 completes the inflation of the hollow capsule packaging bag 16 in the capsule packaging box 2, it pushes the capsule packaging box 2 to the packaging box passing mechanism. At this time, the reflective photoelectric switch 44 detects that there is no capsule packaging box 2 under the top plate 4, and controls the conveying mechanism 1 to continue conveying and transport the next capsule packaging box 2 to the bottom of the top plate 4.

[0039] The lower surface of the top plate 4 is provided with two carton positioning mechanisms 5, which are respectively located at diagonally opposite positions on the lower surface of the top plate 4. The carton positioning mechanisms 5 include a cylinder 20, a connecting block 21 and an L-shaped positioning plate 22. The connecting block 21 is fixedly connected to the piston rod of the cylinder 20, and the L-shaped positioning plate 22 is fixedly connected to the lower surface of the connecting block 21, and the L-shaped positioning plate 22 is vertically arranged. When the capsule packaging box 2 is conveyed to the bottom of the top plate 4, the position of the capsule packaging box 2 when it stops cannot be very accurate due to uncertain factors such as inertia and the time when the conveying mechanism 1 stops. By starting the cylinder 20, the L-shaped positioning plates 22 located at the diagonal corners of the capsule packaging box 2 are driven to move toward the capsule packaging box 2 at the same time. When the piston rod of the cylinder 20 is completely retracted into the cylinder body of the cylinder 20, the inner walls of the L-shaped positioning plates 22 on the diagonal sides of the capsule packaging box 2 are just in close contact with the outer walls of the capsule packaging box 2, and the capsule packaging box 2 is moved to just below the top plate 4, completing the positioning of the capsule packaging box 2, so that the injection needle 10 from the air mechanism can be aligned with the injection hole 12 on the capsule packaging box 2.

[0040] An air-filling mechanism 6 is provided on one side of the conveying mechanism 1. The air-filling mechanism 6 is located at the rear side of the bracket 3. The air-filling mechanism 6 includes a moving plate 7 and a driving assembly 8 for driving the moving plate 7 to move. The driving assembly 8 includes a fixed base 23 and a second cylinder 24. A plurality of air-filling tracks 25 are provided in parallel on the upper surface of the fixed base 23. The lower end of the moving plate 7 is slidably connected to the air-filling tracks 25. The second cylinder 24 is provided on the upper surface of the fixed base 23 and is located on the side of the moving plate 7 away from the conveying mechanism 1. The piston rod of the second cylinder 24 is fixedly connected to the side wall of the moving plate 7. The second cylinder 24 is controlled to drive the moving plate 7 to move closer to and away from the capsule packaging box 2 on the air-filling track 25.

[0041] A plurality of inflatable components 9 are arranged on the upper surface of the movable plate 7, and the inflatable components 9 are arranged at intervals along the length direction of the movable plate 7. The inflatable components 9 include an injection needle 10, an inflatable fixed frame, an inflatable pump 27 and an air pump 28 fixed on the inflatable fixed frame, and a vent 29 fixed in the middle of the bracket 3. The diameter of the injection needle 10 is 1.5-2 mm. The end of the injection needle 10 is hemispherical and sealed, and a plurality of gas passage holes 19 are provided on the side wall of the injection needle 10 near the end. One end of the vent 29 is connected to the injection needle 10, and the inflatable pump 27 and the air pump 28 are connected to the inflatable pipe 47 and the air pump 46 respectively. A three-way pipe fitting 30 is arranged between the end of the vent 29 away from the injection needle 10, the end of the inflatable pipe 47 away from the inflatable pump 27, and the end of the air pump 46 away from the air pump 28. A solenoid valve 1 31 is provided between the three-way pipe fitting 30 and the air pump 27, and a solenoid valve 2 32 is provided between the three-way pipe fitting 30 and the air pump 28. After the injection needle 10 is inserted into the hollow capsule packaging bag 16, it is necessary to first control the solenoid valve 1 31 to be closed, the solenoid valve 2 32 to be opened, and the air pump 28 to be started to extract the air in the hollow capsule packaging bag 16, and then control the solenoid valve 1 31 to be opened, the solenoid valve 2 32 to be closed, and the air pump 27 to be started to fill the hollow capsule packaging bag with ethylene oxide gas. Preferably, the air pump may not be used, and by controlling the pressure value of the ethylene oxide gas in the gas storage tank, the gas pressure in the gas storage tank is relatively large after the solenoid valve 3 is opened, and the gas will be automatically filled into the hollow capsule packaging bag, and the filling amount of the ethylene oxide gas is controlled by controlling the opening time of the solenoid valve 3.

[0042] A gas supply mechanism 11 is provided on one side of the gas charging mechanism 6. The gas supply mechanism 11 includes an ethylene oxide gas cylinder 33 and a gas storage tank 34. A gas delivery pipe 35 is connected between the ethylene oxide gas cylinder 33 and the gas storage tank 34. During production, the valve on the ethylene oxide gas cylinder 33 is opened to allow ethylene oxide to flow into the gas storage tank 34. The gas storage tank 34 heats the ethylene oxide to turn it into ethylene oxide gas. An air delivery pipe 36 is connected between the gas outlet of the gas storage tank 34 and the gas charging pump 27. An electromagnetic valve 3 37 is provided on the air delivery pipe 36. When the electromagnetic valve 1 31 is opened, the electromagnetic valve 3 37 is controlled to open at the same time, so that the ethylene oxide gas in the gas storage tank 34 enters the gas charging pump 27. An ethylene oxide leakage monitor is provided at the electromagnetic valve 3 37. The ethylene oxide leakage monitor can monitor the leakage of ethylene oxide at the gas supply mechanism 11 and give an alarm when a leakage occurs.

[0043] Example 2

[0044] After the hollow capsule is filled with medicine, it is part of the oral capsule. According to the requirements of non-sterile preparations, aerobic bacteria should not exceed 1000 cfu / g, and molds and yeasts should not exceed 100 cfu / g. Because gelatin comes from animals, Escherichia coli and Salmonella are further controlled. Thus, the hollow capsules sterilized by ethylene oxide filling using the method of Example 1 were tested for microbial limits.

[0045] Microbial limit detection method and standard: Take empty capsules and inspect them according to the law (General Rules 1105 and 1106 of Part IV of the 2015 edition of the Chinese Pharmacopoeia). The total number of aerobic bacteria in every 1g of the test sample shall not exceed 1000 cfu, the total number of molds and yeasts shall not exceed 100 cfu, and Escherichia coli shall not be detected; Salmonella shall not be detected in every 10g of the test sample.

[0046] Three groups of hollow capsules from different batches were taken, namely experimental group 1, experimental group 2 and experimental group 3, and the test data before sterilization and after sterilization according to Example 1 were compared. The following table was prepared based on the test results.

[0047] Before sterilization of experimental group 1: aerobic bacteria>1000cfu / g; molds and yeasts>100cfu / g; Escherichia coli was not detected / g; Salmonella was not detected / 10g. After sterilization of experimental group 1: aerobic bacteria<10cfu / g; molds and yeasts<10cfu / g; Escherichia coli was not detected / g; Salmonella was not detected / 10g.

[0048] Before sterilization, the experimental group 2 had aerobic bacteria>1000 cfu / g; molds and yeasts>100 cfu / g; Escherichia coli was not detected / g; Salmonella was not detected / 10 g. After sterilization, the experimental group 2 had aerobic bacteria<10 cfu / g; molds and yeasts<10 cfu / g; Escherichia coli was not detected / g; Salmonella was not detected / 10 g.

[0049] Before sterilization, the experimental group 3 had aerobic bacteria>1000 cfu / g; molds and yeasts>100 cfu / g; Escherichia coli was not detected / g; Salmonella was not detected / 10 g. After sterilization, the experimental group 3 had aerobic bacteria<10 cfu / g; molds and yeasts<10 cfu / g; Escherichia coli was not detected / g; Salmonella was not detected / 10 g.

[0050] According to the test results, it is concluded that the hollow capsules sterilized according to Example 1 meet the various data requirements for non-sterile preparations.

[0051] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications of the above assumptions should also be regarded as the scope of protection of the present invention.

Claims

1. A production line for sterilizing hollow capsules using ethylene oxide, comprising a conveying mechanism (1), a packaging box delivery mechanism, and a capsule packaging box (2) located on the conveying mechanism (1) for delivery, wherein a strapping machine is arranged on a side of the packaging box delivery mechanism away from the conveying mechanism, and wherein: A support (3) is provided at the end of the conveying mechanism (1), and the support (3) includes a top plate (4), and the top plate (4) is located directly above the conveying mechanism (1). Two carton positioning mechanisms (5) are provided on the lower surface of the top plate (4). An inflation mechanism (6) is provided on one side of the conveying mechanism (1), and the inflation mechanism (6) is located on the rear side of the support (3). The inflation mechanism (6) includes a moving plate (7), a pushing component (8) for driving the moving plate (7) to move, and a plurality of inflation components (9) provided on the upper surface of the moving plate (7). The inflation component (9) includes an injection needle (10), and the diameter of the injection needle (10) is 1.5-2 mm. An air supply mechanism (11) is arranged on one side of the inflation mechanism (6); a plurality of injection holes (12) are provided on the side wall of the capsule packaging box (2) near the inflation mechanism (6); a rubber ring (13) is arranged on the injection hole (12); the inner walls of the rubber ring (13) are mutually pressed toward the center position; a plurality of partitions (14) are arranged vertically at intervals inside the capsule packaging box (2); the partitions (14) divide the capsule packaging box (2) into a plurality of storage cavities (15); a hollow capsule packaging bag (16) is placed in the storage cavity (15); the side of the hollow capsule packaging bag (16) near the inflation mechanism (6) is closely attached to the inner wall of the capsule packaging box (2); Two vertical clamping strips (17) are arranged on the inner wall of the storage cavity (15) close to the inflation mechanism (6), and the two clamping strips (17) are respectively located on both sides of the injection insertion hole (12); two strip-shaped clamping blocks (18) are arranged on the hollow capsule packaging bag (16), and the two strip-shaped clamping blocks (18) are slidably inserted in the two clamping strips (17); The end of the injection needle (10) is hemispherical and sealed, and a plurality of gas passage holes (19) are provided on the side wall of the injection needle (10) near the end.

2. A production line for sterilizing hollow capsules with ethylene oxide according to claim 1, characterized in that: The two carton positioning mechanisms (5) are respectively located at diagonally opposite positions on the lower surface of the top plate (4), and the carton positioning mechanism (5) comprises a cylinder (20), a connecting block (21) and an L-shaped positioning plate (22), wherein the connecting block (21) is fixedly connected to the piston rod of the cylinder (20), and the L-shaped positioning plate (22) is fixedly connected to the lower surface of the connecting block (21).

3. The production line for sterilizing hollow capsules with ethylene oxide according to claim 1, characterized in that: The pushing assembly (8) comprises a fixed base (23) and a second cylinder (24); a plurality of inflation rails (25) are arranged in parallel on the upper surface of the fixed base (23); the lower end of the movable plate (7) is slidably connected to the inflation rails (25); the second cylinder (24) is arranged on the upper surface of the fixed base (23) and is located on a side of the movable plate (7) away from the conveying mechanism (1); and the piston rod of the second cylinder (24) is fixedly connected to the side wall of the movable plate (7).

4. A production line for sterilizing hollow capsules with ethylene oxide according to claim 1, characterized in that: The inflation assembly (9) further comprises an inflation fixing frame, an inflation pump (27) and an air extraction pump (28) fixed on the inflation fixing frame, and a ventilation pipe (29) fixed in the middle of the bracket (3); one end of the ventilation pipe (29) is connected to the injection needle (10); and a three-way pipe fitting (30) is provided between the ventilation pipe (29), the inflation pump (27) and the air extraction pump (28).

5. A production line for sterilizing hollow capsules with ethylene oxide according to claim 4, characterized in that: A solenoid valve 1 (31) is provided between the three-way pipe fitting (30) and the inflation pump (27), and a solenoid valve 2 (32) is provided between the three-way pipe fitting (30) and the air extraction pump (28).

6. A production line for sterilizing hollow capsules with ethylene oxide according to claim 5, characterized in that: The gas supply mechanism (11) comprises an ethylene oxide gas cylinder (33) and a gas storage tank (34); a gas delivery pipe (35) is connected between the ethylene oxide gas cylinder (33) and the gas storage tank (34); an air delivery pipe (36) is connected between the gas outlet of the gas storage tank (34) and the air pump (27); and a solenoid valve three (37) is provided on the air delivery pipe (36).

7. A production line for sterilizing hollow capsules with ethylene oxide according to claim 1, characterized in that: A pushing mechanism (38) is arranged on one side of the conveying mechanism (1) close to the inflation mechanism (6), and the pushing mechanism (38) comprises a long-stroke cylinder (39) and a push plate (40). A cylinder mounting frame (41) is arranged on one side of the conveying mechanism (1), and the long-stroke cylinder (39) is fixedly connected to the upper end of the cylinder mounting frame (41). The piston rod of the long-stroke cylinder (39) faces the conveying mechanism (1), and the push plate (40) and the piston rod of the long-stroke cylinder (39) are fixedly connected.

8. The production line for sterilizing hollow capsules with ethylene oxide according to claim 1, characterized in that: A blocking plate (42) is provided on the lower surface of the left side of the top plate (4), a detection hole (43) is provided at the center of the blocking plate (42), and a reflective photoelectric switch (44) is provided in the detection hole (43).

Citation Information

Patent Citations

  • Production line for sterilizing hollow capsules by using ethylene oxide

    CN212501387U