A device for reading blood coagulation and blood coagulation inhibition test results

Abstract

The present invention discloses a device for reading the results of coagulation and coagulation inhibition experiments, comprising a box, a light source is arranged at one end of the box; a coagulation plate tilting assembly is arranged corresponding to the light source, the coagulation plate tilting assembly comprises a coagulation plate adapter and two arms; the two sides of the coagulation plate adapter at one end away from the light source are respectively hinged with the two arms; an arm slide rail fixed to the box is arranged corresponding to each arm; the box also comprises a coagulation plate pushing device, the coagulation plate pushing device comprises a lead screw assembly and a motor; an adapter slide rail is fixed in the box, the coagulation plate pushing device can push the coagulation plate adapter to tilt downward along the adapter slide rail to face the light source directly; an image capture device is arranged in the box corresponding to the coagulation plate adapter. The device can automatically tilt the coagulation plate and capture images, avoid safety risks, save time and effort, and reduce result deviations caused by subjective factors.

Description

Technical Field

[0001] The invention belongs to the field of biological detection, and in particular relates to a device for reading blood coagulation and blood coagulation inhibition test results. Background Art

[0002] Hemagglutination and hemagglutination inhibition tests are mainly used to detect antibody levels in serum, which can be used to determine the immune effect of humans or animals after vaccination, and can also be used to determine the infection status. With the continuous development of the breeding industry, the prevention and control of animal diseases is severe. Common diseases such as avian influenza and Newcastle disease in poultry are mainly prevented by vaccination to prevent animal infection. The immune effect of the vaccine needs to be determined by hemagglutination inhibition tests. At present, almost all of them are carried out by manual experimental interpretation, which is cumbersome and cannot be traced.

[0003] The current implementation scheme uses a camera to take pictures on the top of the coagulation plate and tilts the entire device, which has problems such as poor photography effect, poor judgment accuracy, and complex mechanical structure. It also requires frequent contact with the reaction plate, posing a biosafety risk. The original image cannot be retained and cannot be traced. Summary of the invention

[0004] In view of the deficiencies in the above-mentioned prior art, the present invention provides a device for interpreting the results of coagulation and coagulation inhibition experiments, which can automatically tilt the coagulation plate and capture the image, and can further judge the experimental results after image recognition, thereby avoiding the pollution and safety risks of real-time manual interpretation, saving time and effort, and reducing the result deviation caused by subjective factors.

[0005] The specific technical solutions are as follows:

[0006] A device for reading blood coagulation and blood coagulation inhibition test results, comprising a box, one end of which is provided with a light source;

[0007] A blood coagulation plate tilting assembly is arranged corresponding to the light source, and the blood coagulation plate tilting assembly includes a blood coagulation plate adapter and two arms; the blood coagulation plate adapter includes a tray that can accommodate the blood coagulation plate to be placed horizontally and expose the observation area at the bottom of the blood coagulation plate; the two sides of the blood coagulation plate adapter away from the light source are respectively hinged with the two arms; an arm slide rail fixed to the box body is arranged corresponding to each arm; the arm can slide back and forth along the arm slide rail corresponding to the light source;

[0008] The box body also includes a blood coagulation plate pushing device for driving the blood coagulation plate adapter to slide back and forth;

[0009] An adapter slide rail is fixedly arranged in the box body, a pulley corresponding to the adapter slide rail is arranged on the side of the blood coagulation plate adapter close to the light source, and the blood coagulation plate pushing device can push the blood coagulation plate adapter to tilt downward along the adapter slide rail through the pulley by rotating the lead screw, and make the upper surface of the tray on the blood coagulation plate adapter face the light source directly;

[0010] An image capture device is arranged in the box body corresponding to the blood coagulation plate adapter. When the blood coagulation plate adapter tilts downward along the adapter slide rail, the lens of the image capture device can be aligned with the bottom of the blood coagulation plate adapter.

[0011] The tray preferably has a blood coagulation plate fixing function to prevent the blood coagulation plate from sliding out of the adapter when tilted. A fence can be set for the adapter, or a buckle or other device that can fix the blood coagulation plate can be set.

[0012] When the blood coagulation plate is tilted and facing the light source, it is preferably in close contact with the light source to reduce interference caused by light reflection and refraction and ensure clarity and contrast.

[0013] The image capture device is preferably arranged at the other end relative to the light source, away from the light source. The extended focal length can ensure that one camera captures a complete image of the entire panel, without the need to use multiple cameras to take pictures simultaneously.

[0014] When using this device, fix the transparent coagulation plate to the coagulation plate adapter, and make the coagulation plate pushing device push the coagulation plate adapter to slide along the support arm slide rail toward the light source. When the coagulation plate adapter reaches the adapter slide rail, the pulley on its side slides along the adapter slide rail to make it fit and face the light source directly. The light source is on to provide uniform background light, directly shining on the coagulation plate. The lens of the image capture device is preferably at an angle of 90° to the coagulation plate to take a photo of the bottom of the coagulation plate and capture the flow state image. The result of coagulation or coagulation inhibition can be judged based on the real-time image captured.

[0015] Furthermore, the coagulation plate pushing device includes a screw assembly and a motor; the screw assembly includes a screw and a screw nut connected to the screw; the screw nut is fixed to the end of the coagulation plate adapter away from the light source; the motor is fixed in the box to drive the screw to rotate.

[0016] Furthermore, a mounting plate is fixed in the box, and the motor is fixed to the mounting plate. The motor and the lead screw are preferably connected via a coupling.

[0017] Furthermore, the device also includes a control circuit board, which controls the tilting and resetting of the blood coagulation plate adapter, the turning on and off of the light source, and the capture of the image.

[0018] Furthermore, the control circuit board also controls the preprocessing of the image, which includes image single hole segmentation, binarization, and calculation of parameters such as teardrop length and wave crest.

[0019] The result analysis software can be designed according to the image preprocessing parameters, receive the image preprocessing data, determine the final potency according to the determination rules, store the original image and the determination results in the database, and generate an experimental report.

[0020] Furthermore, the device also includes a power supply module to provide power supply for all circuit parts.

[0021] Furthermore, the image capture device is a high-definition industrial camera that captures the flow status image in real time; the axis of the high-definition industrial camera lens is perpendicular to the plane of the blood coagulation plate adapter after it is tilted into place.

[0022] Furthermore, there are two adapter slide rails, which are symmetrically arranged on both sides of the blood coagulation plate adapter.

[0023] Furthermore, a dust-blocking door that can slide back and forth horizontally relative to the direction of the light source is provided at the upper end of the box. When the coagulation plate needs to be loaded, the dust-blocking door is slid to the side away from the light source to expose the coagulation plate adapter; when the coagulation plate is tilted, the dust-blocking door is slid toward the light source to block the bottom of the coagulation plate to prevent dust from affecting the shooting, and it can also serve as a light-blocking plate for focusing. The opening and closing of the dust-blocking door can be controlled by a control circuit board. Specifically, the initial position, i.e., the door opening position, is determined by a photoelectric sensor; the motor drives the coagulation plate to slide along a fixed track through a lead screw, and the stop position, i.e., the door closing position, is determined according to the set inclination angle.

[0024] Furthermore, if a dust shielding door is not installed on the device, a light shielding plate is preferably provided on the upper end of the light source.

[0025] The beneficial effects of the present invention are as follows:

[0026] The present invention can realize the automatic tilting of the coagulation plate in the coagulation and coagulation inhibition experiments, and perform clear and accurate image capture, which solves the problem that the traditional manual operation requires frequent contact with the reaction plate and brings biosafety risks; and effectively improves the experimental efficiency and interpretation accuracy, and can retain the original image for traceability. The device of the present invention can cooperate with the image recognition and processing module to judge the experimental results, further improve the interpretation accuracy and efficiency, and avoid the errors caused by subjective factors in manual interpretation; and can be connected with the laboratory management system, which is conducive to improving the information level of the laboratory. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a top view schematic diagram of the horizontal state of the blood coagulation plate of the present invention;

[0028] Figure 2It is a front view schematic diagram of the horizontal state of the internal blood coagulation plate of the present invention;

[0029] Figure 3 It is a front view schematic diagram of the state of the internal blood coagulation plate of the present invention during the tilting process;

[0030] Figure 4 It is a front view schematic diagram of the state where the internal blood coagulation plate of the present invention is tilted;

[0031] Figure 5 It is a top view schematic diagram of the blood coagulation plate of the present invention in a tilted state;

[0032] Figure 6 The photo of the blood coagulation plate obtained by the present invention and its processing flow.

[0033] In the figure: 1. light source; 2. coagulation plate adapter; 3. support arm; 4. support arm slide rail; 4.1. slider; 5. motor; 6. lead screw; 7. adapter slide rail; 8. dust shield door; 9. high-definition industrial camera; 10. mounting plate; 11. coupling; 12. coagulation plate. DETAILED DESCRIPTION

[0034] The principles and features of the present invention are described below in conjunction with examples. The examples are only used to explain the present invention and are not used to limit the scope of the present invention.

[0035] A device for interpreting the results of blood coagulation and blood coagulation inhibition experiments, such as Figure 1-5 As shown, it comprises a box body with an upper opening, and a light source 1 is arranged at one end of the box body;

[0036] A blood coagulation plate tilting assembly is arranged corresponding to the light source 1, and the blood coagulation plate tilting assembly includes a blood coagulation plate adapter 2 and a support arm 3; the blood coagulation plate adapter 2 includes a tray that can accommodate the blood coagulation plate 12 for horizontal fixed placement and expose the observation area at the bottom of the blood coagulation plate 12; the two sides of the blood coagulation plate adapter 2 at one end away from the light source 1 are respectively hinged to the two support arms 3; corresponding to each support arm 3, a support arm slide rail 4 fixed to the box body is respectively arranged; the support arm 3 can slide back and forth along the support arm slide rail 4 corresponding to the light source 1 through a slider 4.1;

[0037] The box body also includes a blood coagulation plate pushing device for driving the blood coagulation plate adapter to slide back and forth, and the blood coagulation plate pushing device includes a lead screw assembly and a motor 5; the lead screw assembly includes a lead screw 6 and a lead screw nut connected to the lead screw 6; the lead screw nut is fixed to the end of the blood coagulation plate adapter 2 away from the light source 1; a mounting plate 10 is fixed in the box body, and the motor 5 is fixed to the mounting plate 10; the motor 5 is connected to the lead screw 6 through a coupling 11 to drive the lead screw 6 to rotate;

[0038] The adapter slide rail 7 is fixedly arranged in the box body, and a pulley corresponding to the adapter slide rail 7 is arranged on the side of the blood coagulation plate adapter 2 close to the light source 1, and the blood coagulation plate pushing device can push the blood coagulation plate adapter 2 to tilt downward along the adapter slide rail 7, and make the upper surface of the tray on the blood coagulation plate adapter 2 directly face and fit the light source 1;

[0039] A dust-blocking door 8 is provided at the upper end of the box body and can slide back and forth horizontally relative to the direction of the light source 1;

[0040] A high-definition industrial camera 9 is arranged in the box corresponding to the blood coagulation plate adapter 2. When the blood coagulation plate adapter 2 is tilted downward along the adapter slide rail 7, the lens of the high-definition industrial camera 9 can be aligned with the position of the bottom tray of the blood coagulation plate adapter 2, and the axis of the high-definition industrial camera lens 9 is perpendicular to the plane of the blood coagulation plate adapter 2 after tilting into place;

[0041] The device also includes a control circuit board, which controls the tilt and reset of the blood coagulation plate adapter 2, the opening and closing of the light source 1, image capture and image preprocessing; the image preprocessing includes image single hole segmentation, binarization processing, teardrop length and peak parameter calculation; the control circuit can also control the opening and closing of the dust barrier door 8 through a photoelectric sensor;

[0042] The device also includes a power supply module to supply power to all circuits.

[0043] When using the device, open the dust shield door 8, fix the transparent coagulation plate 12 to the coagulation plate adapter 2, start the motor 5, and make the lead screw assembly push the coagulation plate adapter 2 to slide along the support arm slide rail 4 toward the light source 1. When the coagulation plate adapter 2 reaches the adapter slide rail 7, the pulley on its side slides along the adapter slide rail 7 to make it fit and face the light source 1. The light source 1 is in the on state to provide uniform background light and directly illuminate the coagulation plate; the lens of the high-definition industrial camera 9 is preferably at an angle of 90° to the coagulation plate, and a photo of the bottom of the coagulation plate 12 is taken to capture the flow state image; the high-definition industrial camera 9 is connected to a computer, and the image is pre-processed and stored in the computer for manual interpretation; or the result analysis software is designed to determine the final potency according to the judgment rules, and the original image and the interpretation result are stored in the database to generate an experimental report.

[0044] like Figure 6 As shown, it is a photo of the blood coagulation plate obtained by the present invention and its processing flow. When the blood coagulation plate is tilted into place, the flow state of the sample can be clearly captured and further data processing can be performed.

[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A device for interpreting the results of blood coagulation and blood coagulation inhibition tests, characterized in that: It comprises a box body, and a light source (1) is arranged at one end of the box body; A coagulation plate tilting assembly is provided corresponding to the light source (1), and the coagulation plate tilting assembly comprises a coagulation plate adapter (2) and a support arm (3); the coagulation plate adapter (2) comprises a tray capable of accommodating a coagulation plate (12) to be placed horizontally and exposing an observation area at the bottom of the coagulation plate (12); two sides of an end of the coagulation plate adapter (2) away from the light source (1) are respectively hinged to two support arms (3); a support arm slide rail (4) fixed to the box body is provided corresponding to each support arm (3); the support arm (3) can slide back and forth along the support arm slide rail (4); The box body also includes a blood coagulation plate pushing device for driving the blood coagulation plate adapter (2) to slide back and forth; An adapter slide rail (7) is fixedly arranged in the box body, a pulley corresponding to the adapter slide rail (7) is arranged on the side of the blood coagulation plate adapter (2) close to the light source (1), and the blood coagulation plate pushing device can push the blood coagulation plate adapter (2) to tilt downward along the adapter slide rail (7) and make the upper surface of the tray on the blood coagulation plate adapter (2) face the light source (1); An image capture device is arranged in the box body corresponding to the blood coagulation plate adapter (2), and when the blood coagulation plate adapter (2) is tilted downward along the adapter slide rail (7), the lens of the image capture device can be aligned with the bottom of the blood coagulation plate adapter (2); The image capture device is a high-definition industrial camera (9), and the lens axis of the high-definition industrial camera (9) is perpendicular to the plane of the blood coagulation plate adapter (2) after being tilted into place; A dust-blocking door (8) which can slide back and forth horizontally in the direction of the light source (1) is arranged at the upper end of the box.

2. The blood coagulation and blood coagulation inhibition test result interpretation device according to claim 1, characterized in that: The blood coagulation plate pushing device comprises a lead screw assembly and a motor (5); the lead screw assembly comprises a lead screw (6) and a lead screw nut connected to the lead screw (6); the lead screw nut is fixed to the end of the blood coagulation plate adapter (2) away from the light source (1); the motor (5) is fixed in the box body to drive the lead screw (6) to rotate.

3. The blood coagulation and blood coagulation inhibition test result interpretation device according to claim 2, characterized in that: A mounting plate (10) is also fixedly arranged in the box body, and the motor (5) is fixed to the mounting plate (10).

4. The device for interpreting the results of blood coagulation and blood coagulation inhibition tests according to any one of claims 1 to 3, characterized in that: It also includes a control circuit board, which controls the tilting and resetting of the blood coagulation plate adapter (2), the opening and closing of the light source (1), and the capture of images.

5. The blood coagulation and blood coagulation inhibition test result interpretation device according to claim 4, characterized in that: The control circuit board also controls the pre-processing of the image.

6. The device for interpreting the results of blood coagulation and blood coagulation inhibition tests according to claim 5, characterized in that: Image preprocessing includes image single hole segmentation, binarization, and teardrop length and peak parameter calculation.

7. The device for interpreting the results of blood coagulation and blood coagulation inhibition tests according to any one of claims 1 to 3, characterized in that: A power module is also included to power all circuits.

8. The device for interpreting blood coagulation and blood coagulation inhibition test results according to any one of claims 1 to 3, characterized in that: There are two adapter slide rails (7) symmetrically arranged on both sides of the blood coagulation plate adapter (2).

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