A fully automatic cryoprecipitate preparation instrument

Abstract

The invention discloses a fully automatic cryoprecipitation preparation instrument, comprising a body, a thawing box, a water tank, a water inlet pipe, a drain pipe, a refrigeration component, a freezing component, a temperature sensor, a touch screen, a timer, a controller and a weighing system, wherein the thawing box is arranged at the front of the body, the water tank is arranged at the inner bottom of the body, the thawing box is composed of a double-layer box wall consisting of an inner box wall and an outer box wall, the thawing box is provided with an overflow hole, a water bath and a box cover, one end of the water inlet pipe is connected to the thawing box, and the other end is connected to the water tank, one end of the drain pipe is connected to the overflow hole, and the other end is connected to the water tank; the touch screen is arranged at the top of the body; and the weighing system is arranged at the lower front of the thawing box. The invention can pre-set the freezing time and the thawing time through the touch screen, can freeze and thaw the frozen plasma bag in the water bath, does not require manual operation, and the operation can be performed at night, does not delay the working time during the day, saves time and labor, and improves work efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of medical equipment, and in particular to a fully automatic cryoprecipitate preparation instrument. Background Art

[0002] Cryoprecipitated coagulation factor refers to the blood component obtained by melting fresh frozen plasma at 1℃~6℃ within the storage period by a specific method, separating most of the plasma, and freezing the remaining cold insoluble substances into a solid state within 1 hour. Cryoprecipitated coagulation factor is mainly used for patients with blood diseases, such as congenital or acquired fibrinogen deficiency, congenital or acquired coagulation factor VIII deficiency, vascular hemophilia, children and mild adult hemophilia A, etc. Cryoprecipitated coagulation factor is prepared from fresh frozen plasma separated from whole blood by the blood collection and supply unit. At present, the preparation cycle of cryoprecipitated coagulation factor in blood stations is long. Operators need to freeze fresh plasma in the freezing warehouse, and then transfer the frozen solid fresh frozen plasma to the cryoprecipitation preparation instrument for thawing and preparing cryoprecipitate. In this process, operators have to shuttle back and forth between different equipment, which is labor-intensive. In addition, the thawing time of fresh frozen plasma frozen in a solid state is very long, about 15 hours. Thawing during daytime working hours will greatly reduce production efficiency and be time-consuming and labor-intensive. Summary of the invention

[0003] The purpose of the present invention is to provide a fully automatic cryoprecipitate preparation instrument to solve one or more technical problems existing in the prior art and at least provide a beneficial choice or create conditions.

[0004] The technical solutions adopted to solve the above technical problems are:

[0005] A fully automatic cryoprecipitate preparation instrument, comprising:

[0006] A machine body, wherein the machine body is provided with a water inlet end;

[0007] A water circulation system, comprising a thawing box and a water tank, wherein the thawing box is arranged at the front of the machine body, and the water tank is arranged at the inner bottom of the machine body, wherein the thawing box has a double-layer box wall consisting of an inner box wall and an outer box wall, wherein the thawing box is provided with a water inlet, an overflow hole, a water bath and a box cover, and wherein the water tank is provided with a water inlet and a water outlet, wherein the water inlet, the overflow hole, the water inlet and the water outlet are interconnected through a pipeline;

[0008] The temperature control system comprises a refrigeration component, a freezing component and a temperature sensor, wherein the refrigeration component comprises a refrigeration evaporator, which is arranged in a water tank, the freezing component comprises a freezing evaporator, which is arranged in a double-layer tank wall, and the temperature sensor is arranged in the water tank;

[0009] A central control system, including a touch screen, a timer and a controller, wherein the touch screen is arranged on the top of the machine body, and the timer, the water circulation system and the temperature control system are all connected to the controller;

[0010] The weighing system is arranged at the lower front of the thawing box.

[0011] A touch screen, a timer and a controller are provided, and the operator can pre-set the freezing time and the thawing time through the touch screen, and can freeze and thaw the blood bags in the water bath. Since the thawing box is a double-layer box wall composed of an inner box wall and an outer box wall, the thawing box is provided with a water inlet, an overflow hole, a water bath and a box cover, and the water tank is provided with a water inlet and a water outlet. The water inlet, the overflow hole, the water inlet and the water outlet are interconnected by pipes, so that water circulates between the thawing box and the water tank. The refrigeration evaporator is arranged in the water tank, and the freezing evaporator is arranged in the double-layer box wall. The freezing and refrigeration operations do not interfere with each other. According to the set time, the blood can be thawed after being frozen in the same device. The water in the water tank circulates continuously in the water tank and the water bath to thaw the fresh frozen plasma frozen in the water bath. No manual operation is required, and the operation can be performed at night without delaying the working time during the day, thus saving time and effort and improving work efficiency.

[0012] As a further improvement of the above technical solution, the water circulation system further includes a water pump and a solenoid valve, the water pump is connected to the pipeline, the solenoid valve is arranged on the pipeline, and the water pump and the solenoid valve are both connected to the controller. The water pump and the solenoid valve are arranged to facilitate adjusting the flow rate and speed of water entering the water bath.

[0013] As a further improvement of the above technical solution, the refrigeration component also includes a refrigeration compressor, a refrigeration liquid storage tank and a refrigeration condenser, which are all arranged at the inner bottom of the body, and the two ends of the refrigeration compressor are respectively connected to the refrigeration condenser and the refrigeration evaporator, and the two ends of the refrigeration liquid storage tank are respectively connected to the refrigeration condenser and the refrigeration evaporator. The water in the water tank reaches a set temperature of 1°C to 6°C through the refrigeration component and then enters the water bath to thaw the fresh frozen plasma frozen into a solid state.

[0014] As a further improvement of the above technical solution, the freezing assembly also includes a freezing compressor, a freezing liquid storage tank and a freezing condenser, which are all arranged at the inner bottom of the body, and the two ends of the freezing compressor are respectively connected to the freezing condenser and the freezing evaporator, and the two ends of the freezing liquid storage tank are respectively connected to the freezing condenser and the freezing evaporator. The fresh plasma in the water bath can be frozen by the freezing assembly.

[0015] As a further improvement of the above technical solution, a heating device for heating the water tank is provided at the inner bottom of the machine body. The heating device is provided to cooperate with the temperature sensor and the refrigeration component to make the water in the water tank reach the set temperature.

[0016] As a further improvement of the above technical solution, the weighing system includes a plurality of weighing boxes and a plurality of weighing components, wherein the plurality of weighing boxes are located below the front of the water bath, and the weighing components are arranged at the bottom of the weighing boxes. The weighing boxes can be arranged to weigh the plasma bags and the transfer bags.

[0017] As a further improvement of the above technical solution, the weighing assembly includes a weighing sensor and a fixing plate, the fixing plate is fixed to the upper surface of the weighing sensor by bolts, a plurality of spring steel balls are arranged on both sides of the fixing plate, and a fixing groove is arranged on the bottom of the side of the weighing box, and the weighing box is clamped on the spring steel balls through the fixing groove. Since the weighing box is clamped on the spring steel balls through the fixing groove, it is convenient to install and disassemble.

[0018] As a further improvement of the above technical solution, a plurality of peristaltic pumps are provided on the front of the thawing box, and the peristaltic pumps are located above the weighing box and the number of the peristaltic pumps is consistent with the number of the weighing boxes. The peristaltic pumps can accurately control the flow rate of the fluid in the catheter, and the peristaltic pumps do not need to contact the fluid in the catheter, and will not contaminate the blood in the catheter.

[0019] As a further improvement of the above technical solution, the top and bottom of the side of the body are provided with heat dissipation holes, and the back of the body is provided with a network cable interface, a power switch, a power cord, and a fuse connected to the power cord. The heat dissipation holes can enable air convection inside the body to prevent overheating of components such as refrigeration and freezing compressors, refrigeration and freezing condensers. The network cable interface can be set for network control, which is convenient for operators to remotely control the entire device through a mobile terminal. A fuse is set, and when the current abnormally rises to a certain height and temperature, it will melt and cut off the current, thereby protecting the safe operation of the circuit of the equipment.

[0020] As a further improvement of the above technical solution, a control panel is provided on the front of the machine body, and multiple groups of display screens and multiple groups of operation buttons are provided on the control panel, and the multiple groups of display screens, multiple groups of operation buttons and the multiple weighing boxes correspond to each other one by one. By providing multiple groups of display screens and multiple groups of operation buttons, batch preparation can be performed simultaneously, or single bag operation can be performed. There is no need to wait for the entire batch preparation to be completed. As long as one bag is prepared, it can be taken out and put into the next bag for preparation, realizing flow-type operation and greatly saving time. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0022] Figure 1 is a stereogram of the present invention;

[0023] Figure 2 is a side cross-sectional view of the present invention;

[0024] Figure 3 is a partial cross-sectional view of the back side of the present invention;

[0025] Figure 4 It is a structural schematic diagram of the weighing assembly of the present invention;

[0026] Figure 5 yes Figure 4 A top view of

[0027] Figure 6 It is a structural schematic diagram of the weighing system of the present invention.

[0028] In the figure, 100-machine body, 110-water inlet end, 120-heat dissipation hole, 130-network cable interface, 140-power switch, 150-power cord, 160-fuse, 200-thawing box, 210-overflow hole, 220-water bath, 230-box cover, 300-water tank, 310-water pump, 320-solenoid valve, 400-touch screen, 500-weighing system, 510-weighing box, 511-fixed groove, 520-weighing sensor, 530-fixed plate, 531-spring steel ball, 600-refrigeration compressor, 610-refrigeration liquid storage tank, 620-refrigeration condenser, 630-refrigeration compressor, 640-refrigeration liquid storage tank, 650-refrigeration condenser, 700-heating device, 800-peristaltic pump, 900-control panel, 910-display screen, 920-operation button. DETAILED DESCRIPTION

[0029] This section will describe in detail the specific embodiments of the present invention. The preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present invention, but it cannot be understood as a limitation on the scope of protection of the present invention.

[0030] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., and orientations or positional relationships indicated are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0031] In the description of the present invention, if there are words such as "several", it means one or more, "more" means more than two, greater than, less than, exceed, etc. are understood as not including the number, and above, below, within, etc. are understood as including the number.

[0032] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0033] Reference Figure 1-6 In an embodiment of the present invention, a fully automatic cold precipitation preparation instrument includes a body 100, on which a water inlet 110 is provided; a water circulation system includes a thawing box 200, a water tank 300, a water inlet pipe and a drain pipe, the thawing box 200 is arranged on the front of the body 100, the water tank 300 is arranged on the inner bottom of the body 100, the thawing box 200 is a double-layer box wall composed of an inner box wall and an outer box wall, the thawing box 200 is provided with an overflow hole 210, a water bath 220 and a box cover 230, one end of the water inlet pipe is connected to the thawing box 200, and the other end is connected to the water tank 300, one end of the drain pipe is connected to the overflow hole 210, and the other end is connected to the water tank 300; the temperature control system includes a refrigeration component, a freezing component and a temperature sensor. The refrigeration component includes a refrigeration evaporator, a refrigeration compressor 600, a refrigeration liquid storage tank 610 and a refrigeration condenser 620. The refrigeration evaporator is arranged in the water tank 300. The refrigeration compressor 600, the refrigeration liquid storage tank 610 and the refrigeration condenser 620 are all arranged at the inner bottom of the body 100. The two ends of the refrigeration compressor 600 are respectively connected to the refrigeration condenser 620 and the refrigeration evaporator. The two ends of the refrigeration liquid storage tank 610 are respectively connected to the refrigeration condenser 620 and the refrigeration evaporator. The freezing component includes a freezing evaporator, a freezing compressor 630, a freezing liquid storage tank 640 and a freezing condenser 650. The freezing evaporator is arranged in a double-layer box wall. The freezing compressor 630, the freezing liquid storage tank 640 and the freezing condenser 650 are all arranged at the inner bottom of the body 100. The two ends of the freezing compressor 630 are respectively connected to the freezing condenser 650 and the freezing evaporator. The two ends of the freezing liquid storage tank 640 are respectively connected to the freezing condenser 650 and the freezing evaporator. The temperature sensor is arranged in the water tank 300; the central control system includes a touch screen 400, a timer and a controller, the touch screen 400 is arranged on the top of the body 100, and the timer, water circulation system and temperature control system are all connected to the controller; the weighing system 500 is arranged below the front of the thawing box 200.

[0034] In some embodiments, the water circulation system further includes a water pump 310 and a solenoid valve 320, the water pump 310 is connected to the water inlet pipe, the solenoid valve 320 is respectively arranged on the water inlet pipe and the drain pipe, and the water pump 310 and the solenoid valve 320 are both connected to the controller.

[0035] In some embodiments, a heating device 700 for heating the water tank 300 is disposed at the inner bottom of the body 100 .

[0036] In some embodiments, the weighing system 500 includes a plurality of weighing boxes 510 and a plurality of weighing components. The plurality of weighing boxes 510 are all located below the front surface of the water bath 220 , and the weighing components are disposed at the bottom of the weighing boxes 510 .

[0037] In some embodiments, the weighing assembly includes a weighing sensor 520 and a fixing plate 530, the fixing plate 530 is fixed to the upper surface of the weighing sensor 520 by bolts, a plurality of spring steel balls 531 are arranged on both sides of the fixing plate 530, a fixing groove 511 is arranged on the bottom of the side of the weighing box 510, and the weighing box 510 is clamped on the spring steel balls 531 through the fixing groove 511. The spring steel balls 531 are inserted into both sides of the fixing plate 530 in a fitting manner. The spring steel balls can be pressed down and can bounce up after being released.

[0038] In some embodiments, a plurality of peristaltic pumps 800 are disposed on the front of the thawing box 200 . The peristaltic pumps 800 are located above the weighing box 510 , and the number of the peristaltic pumps 800 is the same as the number of the weighing boxes 510 .

[0039] In some embodiments, heat dissipation holes 120 are provided at the top and bottom of the side of the body 100 , and a network cable interface 130 , a power switch 140 , a power cord 150 , and a fuse 160 connected to the power cord 150 are provided on the back of the body 100 .

[0040] In some embodiments, a control panel 900 is disposed on the front of the body 100 , and a plurality of display screens 910 and a plurality of operation buttons 920 are disposed on the control panel 900 .

[0041] The method steps for preparing cold precipitated coagulation factor using the fully automatic cold precipitate preparation apparatus of the present invention are as follows:

[0042] After the machine is powered on, the freezing temperature, freezing time, thawing temperature, thawing time and the start time of the peristaltic pump 800 are set through the touch screen 400, wherein the freezing temperature ranges from -20°C to -30°C, and the thawing temperature ranges from 1°C to 6°C. The freezing component starts working first, so that the temperature in the water bath 220 reaches the target freezing temperature;

[0043] After the fresh frozen plasma is separated, all the air in the plasma bag is exhausted into the transfer bag, and the plasma is allowed to fill the connecting pipes between the blood bags. The fresh frozen plasma bag and the transfer bag are placed together in the weighing box 510, and weighed by the weighing sensor 520 under the weighing box 510. The operation is confirmed by pressing the operation button 920, and the display screen 910 prompts the operation. The fresh frozen plasma bag is taken out of the weighing box 510 and placed in the water bath 220 for freezing. The transfer bag is left in the weighing box 510, and the connecting conduit between the two bags is placed in the peristaltic pump 800.

[0044] After the freezing time is over, the freezing component stops running, and according to the predetermined thawing time, the refrigeration component starts to start, and tap water enters the water tank 300 through the water inlet end 110. The water inlet amount is controlled by the solenoid valve, and the water inlet stops when it is full of water. Under the coordinated work of the temperature sensor, the refrigeration component and the heating device 700, the water in the water tank 300 reaches the set thawing temperature, and is pumped into the water bath 220 by the water pump 310. The water inlet hole and the overflow hole of the thawing box 200 and the pipes between the water inlet and the water outlet of the water tank 300 are interconnected, so that the water circulation maintains the set thawing temperature in the water bath 220;

[0045] The peristaltic pump 800 is turned on, and the fresh frozen plasma in the water bath 220 melts while flowing from the plasma bag at a high position to the transfer bag at a low position through the peristaltic pump 800. When the residual volume in the plasma bag reaches a user-preset value, the peristaltic pump 800 is turned off;

[0046] The operator takes out the plasma bag with cold precipitate formed in the water bath 220 and the transfer bag with plasma flowing in, and disconnects them by heat sealing.

[0047] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art may make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A fully automatic cryoprecipitate preparation apparatus, characterized in that: include: A machine body, wherein the machine body is provided with a water inlet end; A water circulation system, comprising a thawing box and a water tank, wherein the thawing box is arranged at the front of the machine body, and the water tank is arranged at the inner bottom of the machine body, wherein the thawing box has a double-layer box wall consisting of an inner box wall and an outer box wall, wherein the thawing box is provided with a water inlet, an overflow hole, a water bath and a box cover, and wherein the water tank is provided with a water inlet and a water outlet, wherein the water inlet, the overflow hole, the water inlet and the water outlet are interconnected through a pipeline; The temperature control system comprises a refrigeration component, a freezing component and a temperature sensor, wherein the refrigeration component comprises a refrigeration evaporator, which is arranged in a water tank, the freezing component comprises a freezing evaporator, which is arranged in a double-layer box wall, and the temperature sensor is arranged in the water tank; the freezing component also comprises a freezing compressor, a freezing liquid storage tank and a freezing condenser, wherein the freezing compressor, the freezing liquid storage tank and the freezing condenser are all arranged at the inner bottom of the machine body, and the two ends of the freezing compressor are respectively connected to the freezing condenser and the freezing evaporator, and the two ends of the freezing liquid storage tank are respectively connected to the freezing condenser and the freezing evaporator; A central control system, including a touch screen, a timer and a controller, wherein the touch screen is arranged on the top of the machine body, and the timer, the water circulation system and the temperature control system are all connected to the controller; A weighing system is arranged below the front of the thawing box; The freezing temperature and freezing time can be set through the touch screen, and the freezing temperature range is -20℃~-30℃; The water circulation system further comprises a water pump and a solenoid valve, wherein the water pump is connected to the pipeline, the solenoid valve is arranged on the pipeline, and both the water pump and the solenoid valve are connected to the controller.

2. The fully automatic cryoprecipitate preparation apparatus according to claim 1, characterized in that: The refrigeration component also includes a refrigeration compressor, a refrigeration liquid storage tank and a refrigeration condenser. The refrigeration compressor, the refrigeration liquid storage tank and the refrigeration condenser are all arranged at the inner bottom of the body. The two ends of the refrigeration compressor are respectively connected to the refrigeration condenser and the refrigeration evaporator, and the two ends of the refrigeration liquid storage tank are respectively connected to the refrigeration condenser and the refrigeration evaporator.

3. The fully automatic cryoprecipitate preparation apparatus according to claim 1, characterized in that: The inner bottom of the machine body is provided with a heating device for heating the water tank.

4. The fully automatic cryoprecipitate preparation apparatus according to claim 1, characterized in that: The weighing system comprises a plurality of weighing boxes and a plurality of weighing components. The plurality of weighing boxes are all located below the front surface of the water bath, and the weighing components are arranged at the bottom of the weighing boxes.

5. The fully automatic cryoprecipitate preparation apparatus according to claim 4, characterized in that: The weighing assembly includes a weighing sensor and a fixing plate, the fixing plate is fixed to the upper surface of the weighing sensor by bolts, a plurality of spring steel balls are arranged on both sides of the fixing plate, a fixing groove is arranged on the bottom of the side of the weighing box, and the weighing box is clamped on the spring steel balls through the fixing groove.

6. The fully automatic cryoprecipitate preparation apparatus according to claim 4, characterized in that: A plurality of peristaltic pumps are arranged on the front of the thawing box. The peristaltic pumps are located above the weighing box and the number of the peristaltic pumps is consistent with the number of the weighing boxes.

7. The fully automatic cryoprecipitate preparation apparatus according to claim 1, characterized in that: The top and bottom of the side of the machine body are both provided with heat dissipation holes, and the back of the machine body is provided with a network cable interface, a power switch, a power cord and a fuse connected with the power cord.

8. The fully automatic cryoprecipitate preparation apparatus according to claim 4, characterized in that: A control panel is provided on the front of the machine body. A plurality of display screens and a plurality of operation buttons are provided on the control panel. The plurality of display screens, the plurality of operation buttons and the plurality of weighing boxes correspond to each other one by one.

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