Multi-channel biological 3D printing fast material replacement loading nozzle and 3D printing device

Abstract

The present application provides a multi-channel biological 3D printing fast material change loading nozzle and 3D printing device, the nozzle includes: a support structure, the lower cavity is used to accommodate a syringe seat containing multiple syringes; the upper cavity is provided with a cylinder and a nozzle fixing plate; the nozzle fixing plate is respectively provided with multiple nozzles; the nozzle fixing plate can move up and down along the penetrating guide column under the action of the cylinder, so that each nozzle can be respectively in contact with or separated from the corresponding syringes; the cylinder and each nozzle are respectively connected to the air pipe of the external air intake device; when each nozzle is in contact with each syringe, air is inhaled through the air pipe so that at least part of the printing material in the syringe is squeezed out to achieve printing. The present application aims to adopt a pneumatic method, which can realize multi-channel simultaneous printing, as well as the bracket printing of 6 / 12 / 24 / 48-well plates, which can greatly reduce the time of material change during the printing process of high-throughput printers and improve work efficiency. Multiple parts of the device are detachable for easy disinfection and cleaning.

Description

Technical Field

[0001] The present application relates to the technical field of biological 3D printing equipment, and specifically to a multi-channel biological 3D printing rapid material replacement and loading nozzle and a 3D printing device. Background Art

[0002] 3D printing technology can meet personalized, small-batch, and large-scale medical needs. It has been widely used in the manufacturing of in vitro medical devices and is now expanding into areas such as personalized permanent implants, clinical repair treatments, and drug development trials. In the future, it will focus on the direct printing of biological tissues and organs.

[0003] The high-throughput bioprinter for 6 / 12 / 24 / 48-well plates can quickly print multiple biological units and has good application prospects in drug screening and tissue engineering. The high-throughput printing nozzle for well plates is the key to this technology. This patent aims to solve the problem of feeding and rapid material changing of the printing nozzle of the high-throughput printer.

[0004] For example, patent 201910221420.5 designs a high-throughput feeding printing nozzle. Although it can achieve delay-free switching of various materials, it does not solve the problem of rapid material replacement, and the replacement of materials is also very complicated. In addition, due to the particularity of biological materials, there are great problems with the cleaning and disinfection of such nozzles.

[0005] The existing biological 3D printers for high-throughput matching well plates are basically in a blank state, and the loading nozzles that can be used for rapid material replacement are also in a technical blank stage. Summary of the invention

[0006] In view of the above-mentioned shortcomings of the prior art, the technical problem to be solved by the present application is to provide a multi-channel biological 3D printing fast material replacement and loading nozzle and a 3D printing device to solve at least one problem in the prior art.

[0007] To achieve the above-mentioned purpose and other related purposes, the present application provides a multi-channel biological 3D printer fast material replacement and loading nozzle, the nozzle comprising: a supporting structure, which is provided with an upper cavity and a lower cavity; the lower cavity is used to accommodate a syringe seat containing multiple syringes; the upper cavity is provided with a cylinder and a nozzle fixing plate; the nozzle fixing plate is provided with multiple nozzles corresponding to the positions of each syringe on the syringe seat; the nozzle fixing plate can move up and down along the guide column passing through it under the action of the cylinder, so that each nozzle can be respectively contacted or separated from the corresponding syringe; the cylinder and each nozzle are respectively connected to an air pipe of an external air intake device; when each nozzle is in contact with each syringe, air is introduced through the air pipe so that at least part of the printing material in the syringe is squeezed out to achieve printing.

[0008] In one embodiment of the present application, the supporting structure includes: a top plate, a partition, a back plate and two side plates; wherein, guide pillars are provided between the bottom of the top plate and the top of the partition at four corners to form an upper cavity; the two sides of the bottom of the partition are respectively fixed to the two side plates to form a lower cavity; the back plate passes through the upper cavity and the lower cavity, and is respectively fixed to the rear side of the top plate and the rear side of the partition; an outer shell is provided around the outer side of the upper cavity; the parts of the back plate respectively located on the upper cavity and the lower cavity are provided with one or more back plate connection fixing holes for fixing to the biological 3D printer.

[0009] In one embodiment of the present application, a plurality of air nozzle channels are respectively provided on the partition corresponding to the positions of each syringe on the syringe seat, so that each air nozzle on the air nozzle fixing plate can pass through; wherein the diameter of the air nozzle channel is larger than the diameter of the air nozzle and smaller than the diameter of the syringe.

[0010] In one embodiment of the present application, one or more cylinders are fixed to the bottom of the top plate; each of the cylinders is provided with a cylinder air pipe quick connector, and the cylinder air pipe quick connector is connected to the air pipe of an external air intake device; a push rod of each of the cylinders is fixed to the air nozzle fixing plate, so that the push rod can drive the air nozzle fixing plate to move up and down along the guide column passing through it.

[0011] In one embodiment of the present application, an air pipe inlet and outlet are provided on the top plate so as to connect the air pipe of an external air intake device to the air cylinder and each of the air nozzles respectively.

[0012] In one embodiment of the present application, a plurality of threaded holes are respectively provided on the air nozzle fixing plate corresponding to the positions of each syringe on the syringe seat; the upper half of each threaded hole on the air nozzle fixing plate is used for detachably fixing the air nozzle air pipe quick connector; wherein, the upper part of the air nozzle air pipe quick connector is detachably connected to the air pipe of an external air intake device; the middle part of the air nozzle air pipe quick connector is a nut-like structure; the lower outer side of the lower part of the air nozzle air pipe quick connector is provided with a thread matching the threaded hole; the air nozzle air pipe quick connector is provided with a hollow air duct inside; the lower half of each threaded hole on the air nozzle fixing plate is used for detachably fixing the air nozzle; wherein, the upper outer side of the air nozzle is provided with a thread matching the threaded hole; the lower part of the air nozzle is provided with a circle of rubber ring groove for nesting a rubber ring with a diameter larger than the diameter of the syringe; the air nozzle is provided with a hollow air duct inside.

[0013] In one embodiment of the present application, the four corners of the air nozzle fixing plate are respectively provided with bearing fixing holes; a bearing is placed in each bearing fixing hole; a guide column is passed through each bearing to enable the air nozzle fixing plate to move up and down along the guide column.

[0014] In one embodiment of the present application, a position buckle and a support slide are respectively provided on the inner side of the bottom of each side panel to facilitate the syringe seat to be placed in or taken out of the lower cavity.

[0015] In one embodiment of the present application, the syringe seat is provided with a plurality of syringe slots for placing syringes; a handle is provided on the front side of the syringe seat; the syringe is placed into a piston after the printing material is placed therein; a screw-mouth needle is provided on the head of the syringe; after the syringe is placed into the syringe slot from top to bottom, part of the barrel of each syringe is exposed above the syringe seat, and all of the screw-mouth needles are exposed below the syringe seat; when the air nozzle contacts the syringe, gas is sent into the syringe through the air nozzle connected to the air pipe, so that the piston moves downward, thereby squeezing the printing material in the syringe to achieve printing.

[0016] To achieve the above-mentioned purpose and other related purposes, the present application provides a 3D printing device, which includes: the multi-channel biological 3D printer rapid material replacement and loading nozzle as described above, the biological 3D printer, the air intake device and the printing platform.

[0017] As described above, the present application discloses a multi-channel biological 3D printing fast material change and loading nozzle and a 3D printing device, wherein the nozzle comprises: a supporting structure, which is provided with an upper cavity and a lower cavity; the lower cavity is used to accommodate a syringe seat containing multiple syringes; the upper cavity is provided with a cylinder and an air nozzle fixing plate; the air nozzle fixing plate is provided with multiple air nozzles at positions corresponding to each syringe on the syringe seat; the air nozzle fixing plate can move up and down along the guide column passing through it under the action of the cylinder, so that each air nozzle can be respectively contacted or separated from the corresponding syringe; the cylinder and each air nozzle are respectively connected to an air pipe of an external air intake device; when each air nozzle is in contact with each syringe, air is introduced through the air pipe so that at least part of the printing material in the syringe is squeezed out to achieve printing.

[0018] It has the following beneficial effects:

[0019] The present application aims to solve the problems of rapid material replacement and sterilization of high-throughput bioprinter nozzles. It adopts a modular component syringe holder and an ordinary medical syringe, which is fixed pneumatically to achieve multi-channel simultaneous printing and printing of 6 / 12 / 24 / 48-well plate brackets. It can greatly reduce the time for material replacement during the printing process of high-throughput printers and improve work efficiency. Multiple parts of the device are detachable for easy disinfection and cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 Shown is a schematic structural diagram of a multi-channel biological 3D printer rapid material change loading nozzle in one embodiment of the present application.

[0021] Figure 2Shown is a structural schematic diagram of a support structure in an embodiment of the present application.

[0022] Figure 3 Shown is a schematic structural diagram of a multi-channel biological 3D printer rapid material replacement and loading nozzle with a housing in one embodiment of the present application.

[0023] Figure 4 Shown is a structural schematic diagram of a gas nozzle fixing plate in one embodiment of the present application.

[0024] Figure 5 Shown is a schematic structural diagram of a syringe seat in one embodiment of the present application. DETAILED DESCRIPTION

[0025] The following describes the embodiments of the present application through specific examples, and those skilled in the art can easily understand other advantages and effects of the present application from the contents disclosed in this specification. The present application can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present application. It should be noted that the following embodiments and features in the embodiments can be combined with each other without conflict.

[0026] It should be noted that the illustrations provided in the following embodiments are only schematic illustrations of the basic concept of the present application. Although the drawings only show components related to the present application rather than being drawn according to the number, shape and size of components in actual implementation, the type, quantity and proportion of each component in actual implementation may be changed arbitrarily, and the component layout may also be more complicated.

[0027] Throughout the specification, when a part is said to be "connected" to another part, this includes not only the case of "direct connection" but also the case of "indirect connection" by placing other elements therebetween. In addition, when a part is said to "include" a certain constituent element, unless otherwise stated, it does not exclude other constituent elements, but means that other constituent elements may be included.

[0028] The terms first, second and third are used to describe various parts, components, regions, layers and / or segments, but are not limited thereto. These terms are only used to distinguish a certain part, component, region, layer or segment from other parts, components, regions, layers or segments. Therefore, the first part, component, region, layer or segment described below may refer to the second part, component, region, layer or segment within the scope of this application.

[0029] Furthermore, as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless there is an indication to the contrary in the context. It should be further understood that the terms "comprise", "include" indicate the presence of the described features, operations, elements, components, items, kinds, and / or groups, but do not exclude the presence, occurrence or addition of one or more other features, operations, elements, components, items, kinds, and / or groups. The terms "or" and "and / or" used herein are interpreted as inclusive, or mean any one or any combination. Therefore, "A, B or C" or "A, B and / or C" means "any of the following: A; B; C; A and B; A and C; B and C; A, B and C". Exceptions to this definition will only occur when the combination of elements, functions or operations is inherently mutually exclusive in some way.

[0030] In order to solve the above problems, this application proposes a multi-channel biological 3D printing fast material change loading nozzle and 3D printing device, aiming to solve the problem of the inability to quickly change materials and the difficulty of sterilization and disinfection in the high-throughput biological printer nozzle. This application mainly adopts a modular component syringe seat and an ordinary medical syringe, which is fixed by pneumatic means, and can realize multi-channel simultaneous printing, as well as the printing of 6 / 12 / 24 / 48-well plate brackets. This will greatly reduce the time for changing materials during the printing process of high-throughput printers and improve work efficiency. In addition, the use of disposable medical syringes reduces the chance of infection during the printing process. Multiple parts of this device are detachable for easy disinfection and cleaning.

[0031] like Figure 1 As shown, a schematic diagram of the structure of a multi-channel biological 3D printing rapid material change loading nozzle in an embodiment of the present application is shown. As shown in the figure, the nozzle comprises: a support structure 1, which is provided with an upper cavity and a lower cavity.

[0032] The lower cavity is used to accommodate a syringe seat 2 containing multiple syringes 21; wherein, the syringe seat 2 can be conveniently placed in or taken out of the lower cavity like a drawer, thereby realizing rapid replacement of biological ink or materials, and facilitating disinfection and cleaning.

[0033] The upper cavity is provided with a cylinder 3 and an air nozzle fixing plate 4; a plurality of air nozzles 41 are respectively provided on the air nozzle fixing plate 4 at positions corresponding to the syringes 21 on the syringe seat 2; the air nozzle fixing plate 4 can move up and down along the penetrating guide column 5 under the action of the cylinder 3, so that each air nozzle 41 can respectively contact or separate from the corresponding syringes 21; the cylinder 3 and each air nozzle 41 are respectively connected to an air pipe 6 of an external air intake device; when each air nozzle 41 contacts each syringe 21, air is introduced through the air pipe 6 so that at least part of the printing material in the syringe 21 is squeezed out to achieve printing.

[0034] In simple terms, the air cylinder 3 is used to control the up and down movement of the air nozzle fixing plate 4. When it moves downward a certain distance, the air nozzles 41 on the air nozzle fixing plate 4 corresponding to the positions of each syringe 21 on the syringe seat 2 can block the opening of the syringe 21. The air nozzle 41 is connected to the air pipe 6 of the external air intake device. By inputting gas through the external air intake device, the biological printing material in the syringe 21 can be squeezed downward through the piston 24 in the syringe 21, thereby realizing multi-channel printing.

[0035] It should be noted that the function of the air nozzle 41 is to connect the air pipe 6 to transmit the gas for squeezing the ink or material in the syringe 21, and on the other hand, the air nozzle fixing plate 4 is controlled up and down through the cylinder 3. When pressed down, the sealing of the opening of the syringe 21 can be ensured, and it is convenient to remove the syringe seat 2 and replace the syringe 21 after lifting. In addition, the air nozzle 41 is also easy to disassemble through the thread design. Therefore, the present application can realize the rapid replacement of biological ink or materials, and facilitate disinfection and cleaning.

[0036] like Figure 2 , which is a schematic diagram of the structure of the support structure 1. As shown in the figure, the support structure 1 includes: a top plate 11, a partition plate 12, a back plate 13 and two side plates 14.

[0037] Among them, guide pillars 5 are respectively provided at four corners between the bottom of the top plate 11 and the top of the partition plate 12 to form an upper cavity. Figure 2 As shown, guide post fixing holes 112 are respectively provided on both sides of the top plate 11, and guide post fixing holes 122 are also respectively provided on both sides of the partition plate 12, so that the guide posts 5 can be fixed by screws.

[0038] The two sides of the bottom of the partition 12 are fixed to the two side plates 14 to form a lower cavity. The back plate 13 penetrates the upper cavity and the lower cavity, and is fixed to the rear side of the top plate 11 and the rear side of the partition 12. The top plate 11 is also provided with a back plate fixing hole 113 for fixing the top plate 11 and the back plate 13 by screws. In addition, Figure 2 As shown, the back plate 13 is provided with one or more back plate connection fixing holes 131 at the part located at the lower cavity, so as to be fixed to the printer by screws.

[0039] The outer side of the upper cavity is surrounded by a shell 7. Figure 3 As shown, it is an overall schematic diagram of a multi-channel biological 3D printer rapid material change and loading nozzle with a housing 7.

[0040] Specifically, the partition 12 is provided with a plurality of air nozzle channels 121 at positions corresponding to the respective needle cylinders 21 on the needle cylinder seat 2, for the respective air nozzles 41 on the air nozzle fixing plate 4 to pass through; wherein the diameter of the air nozzle channel 121 is larger than the diameter of the air nozzle 41, and smaller than the diameter of the needle cylinder 21. That is, when the air nozzle fixing plate 4 moves downward, each air nozzle 41 passes through the air nozzle channel 121 on the partition 12, and when the air nozzle fixing plate 4 moves upward, the needle cylinder 21 is restricted from moving upward, thereby realizing the separation of the air nozzle 41 from the opening of the needle cylinder 21.

[0041] In this embodiment, the top plate 11 is provided with an air pipe inlet and outlet 111 for connecting the air pipe 6 of the external air intake device to the cylinder 3 and each of the air nozzles 41. For example, 18 air pipes 6 can be connected to the cylinder 3 and each of the air nozzles 41 through the air pipe inlet and outlet 111. Figure 1 The air nozzle and air pipe quick connector 42.

[0042] In this embodiment, one or more cylinders 3 are fixed to the bottom of the top plate 11. Figure 2 As shown, the top plate 11 is provided with a cylinder fixing hole 114, and the cylinder 3 is detachably fixed by screws; Figure 1 As shown, each of the cylinders 3 is provided with a cylinder air pipe quick connector 31, and the cylinder air pipe quick connector 31 is connected with an air pipe 6 of an external air intake device. For example, four air pipes 6 are connected to the cylinder air pipe quick connector 31 of the cylinder 3 through the air pipe inlet and outlet 111. Specifically, cylinder air pipe quick connectors 31 are provided on both sides of each cylinder 3, wherein when the cylinder air pipe quick connector 31 on one side is inhaled, the push rod 32 can be controlled to extend so that the air nozzle fixing plate 4 moves downward, and when the cylinder air pipe quick connector 31 on the other side is inhaled, the push rod 32 can be controlled to contract so that the air nozzle fixing plate 4 moves upward.

[0043] The push rod 32 of each cylinder 3 is fixed on the air nozzle fixing plate 4, so that the air nozzle fixing plate 4 can be driven by the push rod 32 to move up and down along the penetrating guide column 5. Figure 4 A push rod fixing hole 321 is shown in the figure for fixing the push rod 32 to the air nozzle fixing plate 4 by screws.

[0044] In the present application, the cylinder 3 can be provided in multiple numbers, such as 2 or 4, respectively provided on both sides of the upper cavity to ensure that the control valve fixing plate 4 is balanced when moving up and down. After adjusting the length of the push rod 32 of the cylinder 3, the push rod 32 can be fixed to the valve fixing plate 4 with screws.

[0045] In this embodiment, if Figure 2 As shown in , a position buckle 141 and a support slide 142 are respectively provided on the inner side of the bottom of each side plate 14 to facilitate the syringe seat 2 to be placed in or taken out of the lower cavity.

[0046] like Figure 4 , which is a schematic diagram of the structure of the air nozzle fixing plate 4. As shown in the figure, the air nozzle fixing plate 4 is provided with a plurality of threaded holes 44 corresponding to the positions of the syringes 21 on the syringe seat 2.

[0047] The upper half of each threaded hole 44 on the air nozzle fixing plate 4 is used for detachably fixing the air nozzle air pipe quick connector 42; wherein, the upper part of the air nozzle air pipe quick connector 42 is detachably connected with the air pipe 6 of the external air intake equipment; the middle part of the air nozzle air pipe quick connector 42 is a nut-like structure; the lower outer side of the air nozzle air pipe quick connector 42 is provided with a thread matching the threaded hole 44; the air nozzle air pipe quick connector 42 is provided with a hollow air duct inside.

[0048] The lower half of each threaded hole 44 on the air nozzle fixing plate 4 is used for detachably fixing the air nozzle 41; wherein, a thread matching the threaded hole 44 is provided on the outer side of the upper part of the air nozzle 41; a circle of rubber ring groove 411 is provided on the lower part of the air nozzle 41 for nesting a rubber ring 412 whose diameter is larger than that of the syringe 21, so as to ensure that there is no air leakage when the air nozzle 41 contacts the syringe 21, and a certain sealing is formed; a hollow air passage is provided inside the air nozzle 41.

[0049] In simple terms, a hollow air passage is provided inside the air nozzle air pipe quick connector 42 and inside the air nozzle 41, and is connected to the threaded hole 44 to form a connected air passage, so that after the air nozzle 41 contacts the syringe 21, the air intake of the air pipe 6 can enter the syringe 21 through the air passage.

[0050] In this embodiment, the four corners of the air nozzle fixing plate 4 are respectively provided with bearing fixing holes 431; a bearing 43 is placed in each bearing fixing hole 431; and a guide column 5 is passed through each bearing 43 to enable the air nozzle fixing plate 4 to move up and down along the guide column 5.

[0051] like Figure 5 , which is a schematic diagram of the structure of the syringe seat 2. As shown in the figure, the syringe seat 2 is provided with N×M syringe slots 211 for placing syringes 21.

[0052] It should be noted that the N×M syringe slots 211 provided on the syringe seat 2 can be respectively provided corresponding to the layout of 6 / 12 / 24 / 48 well plates, for example, 3×4, 4×6, 6×8 well plate layouts, etc. In short, the well plate is provided with N×M grid slots, and each grid slot can be printed by a syringe 21 as in the present application, for example, a bioprinting scaffold model can be formed.

[0053] The front side of the syringe seat 2 is provided with a handle. Figure 2As shown in the figure, the inner side of the bottom of the side plate 14 is respectively provided with a position buckle 141 and a support slide 142, which can facilitate the syringe seat 2 to be placed in or taken out of the lower cavity.

[0054] The piston 24 is placed in the syringe 21 after the printing material is placed therein. When the air nozzle 41 contacts the syringe 21, gas is sent into the syringe 21 through the air nozzle 41 connected to the air pipe 6 to move the piston 24 downward, thereby squeezing the printing material in the syringe 21 to achieve printing.

[0055] In this embodiment, after the material in the syringe 21 is used up, another syringe 21 filled with material can be replaced. Alternatively, the syringe 21 that has been used up can be cleaned and disinfected, and the piston 24 that has been squeezed down can be taken out through subsequent processing. In addition, the present application can also use a disposable medical syringe 21 to reduce the chance of infection during the printing process.

[0056] The head of the syringe 21 is provided with a screw-on needle 22 ; after the syringe 21 is placed into the syringe slot 211 from top to bottom, part of the barrel of each syringe 21 is exposed above the syringe seat 2 , and all of the screw-on needles 22 are exposed below the syringe seat 2 .

[0057] For example, after the above-mentioned components are installed, air is first supplied to the cylinder air pipe quick connector 31 on one side of the two cylinders 3 to extend the push rod 32 of the cylinder 3. Under the action of the two push rods 32, the air nozzle fixing plate 4 is driven to slide downward on the guide column 5. The air nozzle 41 on the air nozzle fixing plate 4 enters the syringe 21 under the action of pressure. The rubber ring 412 installed on the air nozzle 41 is larger than the inner diameter of the syringe 21 to ensure that there is no air leakage.

[0058] At this point, all preparations are completed, and then air is ventilated into the air pipe 6 connected to the air nozzle air pipe quick connector 42. The air pressure enters the syringe 21 through the air nozzle 41 and pushes the piston 24 in the syringe 21 downward. The ink or material in the syringe 21 is squeezed out through the screw needle 22, and 3D printing is achieved under the control of the 3D printer.

[0059] After 3D printing is completed, air is taken in from the air inlet of the two cylinder air pipe quick connectors 31 on the other side of the cylinder 3, causing the push rod 32 of the cylinder 34 to retract. Under the action of the two push rods 32, the air nozzle fixing plate 4 is driven to slide upward on the guide column 5, and the air nozzle 41 moves upward with the syringe 21 under the action of the pulling force. After the syringe 21 hits the partition 12, since the aperture of the air nozzle 41 channel is smaller than the maximum diameter of the syringe 21, the air nozzle 41 can be disengaged from the syringe 21 under the action of the pulling force, and finally the cylinder 3 is reset.

[0060] In the subsequent material replacement process, the handle 23 can be grasped and then the syringe seat 2 can be pulled out in a slightly upward direction to remove the syringe 21 that has run out of ink or material to replace the 3D printing ink or material, or the syringe 21 can be directly replaced.

[0061] In summary, the present application can realize multi-channel simultaneous printing and printing of brackets for 6 / 12 / 24 / 48-well plates. This will greatly reduce the time for changing materials during the printing process of high-throughput printers and improve work efficiency. Multiple parts of the device are detachable for easy disinfection and cleaning.

[0062] To achieve the above-mentioned purpose and other related purposes, the present application provides a 3D printing device, the device comprising: Figure 1 The multi-channel biological 3D printer quickly changes materials and loads nozzles, air intake equipment and printing platforms.

[0063] The multi-channel biological 3D printing fast material change and loading nozzle and 3D printing device described in the present application, the nozzle includes: a supporting structure, which is provided with an upper cavity and a lower cavity; the lower cavity is used to accommodate a syringe seat containing multiple syringes; the upper cavity is provided with a cylinder and a nozzle fixing plate; the nozzle fixing plate is provided with multiple nozzles corresponding to the positions of each syringe on the syringe seat; the nozzle fixing plate can move up and down along the guide column passing through it under the action of the cylinder, so that each nozzle can be respectively contacted or separated from the corresponding syringe; the cylinder and each nozzle are respectively connected to the air pipe of an external air intake device; when each nozzle is in contact with each syringe, air is introduced through the air pipe so that at least part of the printing material in the syringe is squeezed out to achieve printing.

[0064] In summary, the present invention effectively overcomes various shortcomings of the prior art and has high industrial utilization value.

[0065] The above embodiments are merely illustrative of the principles and effects of the present application and are not intended to limit the present application. Anyone familiar with the technology may modify or change the above embodiments without violating the spirit and scope of the present application. Therefore, all equivalent modifications or changes made by a person of ordinary skill in the art without departing from the spirit and technical ideas disclosed in the present application shall still be covered by the claims of the present application.

Claims

1. A multi-channel biological 3D printer rapid material change loading nozzle, characterized in that: The nozzle comprises: A support structure having an upper cavity and a lower cavity; The lower cavity is used to accommodate a syringe seat containing a plurality of syringes; The upper cavity is provided with a cylinder and a nozzle fixing plate; The positions of the air nozzle fixing plate corresponding to the respective syringes on the syringe seat are respectively provided with a plurality of air nozzles; the air nozzle fixing plate can move up and down along the penetrating guide column under the action of the cylinder, so that each air nozzle can be respectively in contact with or separated from each corresponding syringe; The cylinder and each of the air nozzles are respectively connected to an air pipe of an external air intake device; when each of the air nozzles contacts each of the syringes, air is introduced through the air pipe so that at least part of the printing material in the syringe is squeezed out to achieve printing.

2. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 1, characterized in that: The support structure includes: a top plate, a partition plate, a back plate and two side plates; Wherein, guide pillars are provided at four corners between the bottom of the top plate and the top of the partition plate to form an upper cavity; the two sides of the bottom of the partition plate are fixed to two side plates to form a lower cavity; The back plate penetrates the upper cavity and the lower cavity, and is fixed to the rear side of the top plate and the rear side of the partition respectively; The outer side of the upper cavity is surrounded by a shell; The parts of the back plate respectively located on the upper cavity and the lower cavity are provided with one or more back plate connection fixing holes for fixing to the biological 3D printer.

3. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 2, characterized in that: A plurality of air nozzle channels are respectively provided on the partition plate corresponding to the positions of the syringes on the syringe seat, so as to allow the air nozzles on the air nozzle fixing plate to pass through; wherein the diameter of the air nozzle channel is larger than the diameter of the air nozzle and smaller than the diameter of the syringe.

4. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 2, characterized in that: One or more cylinders are fixed to the bottom of the top plate; each cylinder is provided with a cylinder air pipe quick connector, and the cylinder air pipe quick connector is connected to the air pipe of the external air intake equipment; the push rod of each cylinder is fixed to the air nozzle fixing plate, so that the air nozzle fixing plate can be driven by the push rod to move up and down along the penetrating guide column.

5. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 2, characterized in that: The top plate is provided with an air pipe inlet and outlet for connecting the air pipe of an external air intake device to the air cylinder and each of the air nozzles respectively.

6. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 1, characterized in that: The gas nozzle fixing plate is provided with a plurality of threaded holes corresponding to the positions of the syringes on the syringe seat; The upper half of each threaded hole on the gas nozzle fixing plate is used for detachably fixing the gas nozzle air pipe quick connector; wherein, the upper part of the gas nozzle air pipe quick connector is detachably connected to the air pipe of the external air intake device; the middle part of the gas nozzle air pipe quick connector is a nut-shaped structure; the lower outer side of the gas nozzle air pipe quick connector is provided with threads matching the threaded holes; the gas nozzle air pipe quick connector is provided with a hollow airway inside; The lower half of each threaded hole on the air nozzle fixing plate is used for detachably fixing the air nozzle; wherein, a thread matching the threaded hole is provided on the outer side of the upper part of the air nozzle; a circle of rubber ring groove is provided on the lower part of the air nozzle for nesting a rubber ring with a diameter larger than the diameter of the syringe; a hollow air duct is provided inside the air nozzle.

7. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 1, characterized in that: The four corners of the air nozzle fixing plate are respectively provided with bearing fixing holes; a bearing is placed in each bearing fixing hole; a guide column penetrates each of the bearings to enable the air nozzle fixing plate to move up and down along the guide column.

8. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 2, characterized in that: The inner side of the bottom of each side plate is respectively provided with a position buckle and a support slideway to facilitate the syringe seat to be placed in or taken out of the lower cavity.

9. The multi-channel biological 3D printer rapid material change loading nozzle according to claim 1, characterized in that: The syringe seat is provided with a plurality of syringe slots for inserting syringes; a handle is provided on the front side of the syringe seat; The syringe is placed in the piston after the printing material is placed in it; the head of the syringe is provided with a screw-on needle; after the syringe is placed in the syringe slot from top to bottom, part of the barrel of each syringe is exposed above the syringe seat, and all the screw-on needles are exposed below the syringe seat; When the air nozzle contacts the syringe, gas is sent into the syringe through the air nozzle connected to the air pipe, so that the piston moves downward, thereby squeezing the printing material in the syringe to achieve printing.

10. A 3D printing device, characterized in that: The device comprises: A multi-channel biological 3D printer rapid material replacement and loading nozzle, a biological 3D printer, an air intake device and a printing platform as described in any one of claims 1 to 9.

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