An anti-infection nasal vestibule coated stent and its preparation method and application

Abstract

The present invention discloses an anti-infection nasal vestibule coated stent and its preparation method and application. The nasal vestibule coated stent comprises: a stent body, the shape and size of the stent body matches the nasal vestibule morphology; a coating; the coating is compounded on the stent body. The stent body has a shape memory function and is well matched with the morphological structure of the human nasal vestibule. The coating is composed of at least one fiber layer, and the pore size of the fiber layer decreases gradually from the lowest layer of the lower coating to the uppermost layer of the upper coating. The nasal vestibule coated stent provided by the present invention can realize gradient filtration of gas inhaled into the human body through the nose, so as to prevent bronchial, bronchiolar and lung infections in patients with artificial trachea or tracheal stent transplantation. The stent provided by the present invention has a simple structure, is easy to manufacture, beautiful in application, and has a significant anti-infection effect. It can also realize drug loading and drug release of the coated stent, and has multiple additional functional attributes.

Description

Technical Field

[0001] The present invention relates to the technical field of coated stents, and in particular to a nasal vestibule coated stent for resisting respiratory infection in patients with tracheal stent placement or artificial trachea transplantation, and a preparation method and application thereof. Background Art

[0002] The trachea is a major organ of the human respiratory system, located between the larynx and the tracheal bifurcation, and mainly performs the function of gas transportation. The tracheal epithelium is a pseudostratified ciliated columnar epithelium, which contains ciliated columnar cells and goblet cells that produce mucus. The epithelium is usually covered with mucus and cilia. Mucus can moisten the trachea, and mucus contains substances that can resist bacteria and viruses. Cilia movement can remove foreign objects in the trachea, and by swinging in a directional direction toward the larynx, it can remove viruses, bacteria, dust, etc. inhaled into the trachea.

[0003] However, the trachea is often narrowed due to inflammatory granulomas, scars, tuberculosis, trauma, tracheomalacia, amyloidosis, tumors and other lesions. This can cause obstructive pneumonia, atelectasis and dyspnea, and patients may experience symptoms such as wheezing and choking. In severe cases, respiratory failure may occur and endanger life. Tracheal stent implantation is one of the important means to treat tracheal stenosis, which can quickly relieve dyspnea and improve clinical symptoms. Tracheal stents are usually divided into bare stents, semi-covered stents and fully covered stents, and fully covered stents are the most commonly used in clinical practice.

[0004] However, the inventors of this application found that the above technology has at least the following technical problems in the process of implementing the technical solution of the invention in the embodiment of this application:

[0005] Regardless of the type of stent, once implanted in the trachea, it will cause serious damage to the cleaning function of the tracheal epithelium, resulting in reduced mucus secretion and decreased moisture in the trachea. The cilia lose their directional swinging function and are unable to remove viruses, bacteria, dust, etc. inhaled into the trachea. As a result, these tiny particles may directly enter the bronchi and lungs, greatly increasing the incidence of bronchiolitis and pneumonia. It is more likely to cause more serious infections, leading to irreversible damage to the lungs, and causing great physical discomfort, psychological and economic burdens to patients. Summary of the invention

[0006] The embodiments of the present application solve the technical problem in the prior art that patients with artificial trachea or tracheal stent transplants are prone to bronchial, bronchiolar and lung infections by providing an anti-infection nasal vestibule coating stent. An anti-infection nasal vestibule coating stent for patients with tracheal stent placement is proposed, which combines a monofilament braided stent with a 3D coating with gradient filtration function, thereby eliminating the inhalation of fine particles such as viruses and bacteria from the source and reducing the chance of infection in patients.

[0007] The embodiment of the present application provides an anti-infection nasal vestibule stent covering, the nasal vestibule stent covering comprising:

[0008] A stent body, wherein the shape and size of the stent body match the shape of the nasal vestibule;

[0009] Lamination;

[0010] The coating is compounded on the support body.

[0011] Preferably, the bracket body is a bracket body with shape memory function.

[0012] More preferably, the stent body is a mesh structure woven and shaped from shape memory wires.

[0013] Furthermore, the shape memory wire is a metal wire or a polymer wire.

[0014] Furthermore, the metal wire or polymer wire has good biocompatibility.

[0015] Furthermore, the diameter of the metal wire is 0.01-0.5 mm.

[0016] Furthermore, the diameter of the polymer filament is 0.05-0.5 mm.

[0017] Furthermore, the metal wire is one or more of stainless steel wire, nickel wire, titanium wire, cobalt wire, tungsten wire and alloy wires thereof.

[0018] Furthermore, the polymer yarn is one or more of PP, PE, PGA, PGLA, PPDO, PCL, PLA, PGCL, PVA and composite yarns thereof.

[0019] Preferably, the support body includes an upper surface and a lower surface, the coating includes an upper coating and a lower coating, the upper coating is compounded on the upper surface of the support body, and the lower coating is compounded on the lower surface of the support body.

[0020] More preferably, the upper covering film and the lower covering film are respectively composed of at least one fiber layer, and the pore sizes of the fiber layers decrease gradually from the lowest layer of the lower covering film to the highest layer of the upper covering film.

[0021] Furthermore, the upper covering membrane and / or the lower covering membrane has the performance of filtering fine particles. The upper covering membrane and / or the lower covering membrane comprises 1-3 fiber layers, and the pore size of the lower fiber layer is larger than the pore size of the upper fiber layer.

[0022] Preferably, the coating preparation method includes but is not limited to flash evaporation, melt blowing, electrospinning, centrifugal spinning and a combination thereof.

[0023] Preferably, the coating is directly compounded onto the stent body during the molding process.

[0024] Preferably, the stent body and / or the coating are loaded with drugs.

[0025] The present application also provides a method for preparing an anti-infective nasal vestibule stent-covering, the steps of which are:

[0026] Using a mold, a monofilament weaving method is used to form a bracket, wherein the shape and size of the bracket match the nasal vestibule;

[0027] The shape of the stent is fixed by heat setting, so as to obtain a stent body having a shape memory function and a shape and size matching the morphology of the nasal vestibule;

[0028] A micro-nano fiber molding method is adopted to directly mold a coating on the upper surface and the lower surface of the stent body to obtain a nasal vestibule coating stent.

[0029] Preferably, the stent body and / or the covering film are loaded with drugs;

[0030] The method for loading drugs on the film comprises:

[0031] After the film is formed, the drug is loaded onto the film; or

[0032] The drug is pre-loaded into the material, and then the drug-loaded material is directly formed into a coating on the upper surface and the lower surface of the stent body by using a micro-nano fiber molding method;

[0033] The method for loading drugs on the stent body comprises:

[0034] After the stent body is woven and shaped, coating / grafting drugs on the stent body; or

[0035] The drug is pre-coated / grafted onto the monofilaments, and then the monofilaments loaded with the drug are woven into a stent body.

[0036] The embodiments of the present application also provide an application of an anti-infective nasal vestibule coated stent in the preparation of a device for preventing or treating bronchial, bronchiolar and / or lung infections after tracheal stent placement or artificial trachea transplantation.

[0037] One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:

[0038] 1. The embodiment of the present application creatively combines a monofilament braided stent with a 3D coating with a gradient filtering function. First, by weaving a monofilament shape memory stent and heat setting, a stent body that is well matched with the morphological structure of the human nasal vestibule is obtained. Then, by flash evaporation, melt-blowing, electrospinning, centrifugal spinning and their combination, a coating with a continuous pore size gradient is composited on the upper and lower surfaces of the stent body, respectively. Ultimately, gradient filtration is achieved for the gas inhaled into the human body through the nose, thereby preventing bronchial, bronchiolar and lung infections in patients with artificial trachea or tracheal stent transplants.

[0039] 2. The anti-infection nasal vestibule stent coating provided in the embodiments of the present application is particularly targeted at patients with artificial trachea or tracheal stent transplants and can effectively prevent small particles such as viruses, bacteria, and dust from being inhaled into the human body.

[0040] 3. The anti-infection nasal vestibule coating stent provided in the embodiment of the present application has a simple structure, is easy to shape, is beautiful to use, and has a significant anti-infection effect.

[0041] 4. The method for preparing the anti-infective nasal vestibule stent provided in the embodiment of the present application is easy to operate, has low requirements on technology and equipment, is low in cost, and has strong feasibility and promotion value.

[0042] 5. The anti-infection nasal vestibule coated stent provided in the embodiment of the present application can also realize the drug loading and drug release functions of the coated stent without changing the process, and can easily realize multiple additional functions. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 This is a schematic structural diagram of the anti-infection nasal vestibule stent provided in Example 1 of the present application;

[0044] Figure 2 This is a schematic diagram of the structure of the upper coating in Example 1 of the present application;

[0045] Figure 3 This is a schematic diagram of the structure of the lower covering film in the first embodiment of the present application;

[0046] Figure 4 This is a flow chart of the method for preparing the anti-infective nasal vestibule stent coating provided in Example 3 of the present application. DETAILED DESCRIPTION

[0047] The embodiment of the present application solves the technical problem in the prior art that patients with artificial trachea or tracheal stent transplants are prone to bronchial, bronchiolar and lung infections by providing an anti-infection nasal vestibule coated stent.

[0048] The technical solution in the embodiment of the present application is to solve the above-mentioned crosstalk problem, and the overall idea is as follows:

[0049] A nasal vestibule covered stent is proposed to prevent infection in patients with tracheal stent placement, attempting to eliminate the inhalation of fine particles such as viruses and bacteria from the source, bringing good news to patients with artificial trachea or tracheal stent transplants.

[0050] At present, there are no literature reports at home and abroad on the anti-infection nasal vestibule covered stent for patients with tracheal stent placement.

[0051] The present invention creatively combines a monofilament braided stent with a 3D coating with gradient filtering function. First, by weaving a monofilament shape memory stent and heat setting, a stent body that is well matched with the morphological structure of the human nasal vestibule is obtained. Then, by flash evaporation, melt-blowing, electrostatic spinning, centrifugal spinning and their combination, a coating with a continuous pore size gradient is composited on the upper and lower surfaces of the stent body. Finally, gradient filtration is achieved for the gas inhaled into the human body through the nose, so as to prevent bronchial, bronchiolar and lung infections in patients with artificial trachea or tracheal stent transplantation.

[0052] In order to better understand the above technical solution, the above technical solution will be described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0053] Embodiment 1

[0054] Figure 1 This is a schematic diagram of the structure of the anti-infection nasal vestibule stent provided in Example 1 of the present application, wherein the anti-infection nasal vestibule stent comprises:

[0055] A stent body, wherein the shape of the stent body matches the shape of the nasal vestibule to achieve good fit between the stent body and the nasal vestibule;

[0056] Lamination;

[0057] The coating is compounded on the support body.

[0058] like Figure 1 As shown, the stent body 1 is woven from a single shape memory wire and formed into a mesh structure matching the nasal vestibule shape by heat setting. The obtained stent body has shape memory properties, and its morphological structure can fit well with the nasal vestibule of the human body.

[0059] In this embodiment, the single shape memory wire used is a PP wire with a diameter of 0.25 mm. The PP wire has good biocompatibility.

[0060] The support body has two surfaces, an upper surface and a lower surface. The lower surface is located at the lower side (outer side) of the nasal vestibule, that is, the side close to the nose and mouth. The upper surface is located at the upper side (inner side) of the nasal vestibule, that is, the side away from the nose and mouth.

[0061] In a preferred embodiment, the upper surface is a mesh structure surface woven integrally with the peripheral wall of the stent body.

[0062] In another preferred embodiment, the upper surface is an open structure.

[0063] In a preferred embodiment, the lower surface is a mesh structure surface woven integrally with the peripheral wall of the stent body.

[0064] In another preferred embodiment, the lower surface is an open structure.

[0065] The coating includes an upper coating 1 and a lower coating 3 . The upper coating 1 is compounded on the upper surface of the bracket body 2 , and the lower coating 3 is compounded on the lower surface of the bracket body 2 .

[0066] The coating has a gradient filtering function and can filter fine particles. The upper coating 1 and the lower coating 3 are directly compounded on the stent body during molding.

[0067] In this embodiment, the upper film 1 is composed of two fiber layers. Figure 2 As shown, the upper film 1 is composed of the upper and lower films 12 and the upper-upper film 11 compounded in sequence from bottom to top.

[0068] The upper covering film 11 is made of PVA material by an electrostatic spinning method, and has an average pore size of 10 nm.

[0069] The upper and lower covering films 12 are made of PVA material by an electrostatic spinning method, and the average pore size is 100 nm.

[0070] In this embodiment, the lower covering film 3 is composed of three fiber layers, such as Figure 3 As shown, the lower film 3 is composed of a lower upper film 31, a lower middle film 32 and a lower lower film 33 which are compounded in sequence from top to bottom.

[0071] in:

[0072] The lower and upper covering films 31 are made of PP material by melt-blowing method, and the average pore size is 1 μm.

[0073] The lower middle coating 32 is made of PP material by melt-blowing method, and has an average pore size of 2.5 μm.

[0074] The lower covering film 33 is made of PP material by a spunbond method, and has an average pore size of 10 μm.

[0075] The pore sizes of the fiber layers of the lower-lower film 33, the lower-middle film 32, the lower-upper film 31, the upper-lower film 12, and the upper-upper film 11 decrease in sequence. The pore sizes of the fiber layers decrease in sequence from the lowermost surface of the lower film to the uppermost surface of the upper film, which not only achieves effective filtration of the inhaled air, but also does not significantly affect the ventilation rate.

[0076] According to tests, the filtration efficiency of the anti-infective nasal vestibule stent provided in this embodiment is 99%.

[0077] When in use, the nasal vestibule membrane stent is placed in the nasal vestibule of the patient with the tracheal stent placed. The gas inhaled into the human body through the nose is gradiently filtered through the fiber layers of the lower-lower membrane 33, the lower-middle membrane 32, the lower-upper membrane 31, the upper and lower membranes 12, and the upper-upper membrane 11. The filtered gas is clean and sterile.

[0078] Clinical trials have shown that patients with tracheal stent placement who wear the anti-infection nasal vestibule coated stent provided in this embodiment have obvious anti-infection function, and the chances of bronchial, bronchiolar and lung infections are greatly reduced.

[0079] Embodiment 2

[0080] An anti-infection nasal vestibule stent, comprising:

[0081] A stent body, wherein the shape of the stent body matches the shape of the nasal vestibule to achieve good fit between the stent body and the nasal vestibule;

[0082] Lamination;

[0083] The coating is compounded on the support body.

[0084] The stent body is woven from a single shape memory wire and is formed into a mesh structure that matches the nasal vestibule shape by heat setting. The obtained stent body has shape memory performance, and its morphological structure can fit well with the nasal vestibule of the human body.

[0085] In this embodiment, the single shape memory wire used is a nickel-titanium wire with a diameter of 0.01 mm. The nickel-titanium wire has good biocompatibility.

[0086] The support body has two surfaces, an upper surface and a lower surface. The lower surface is located at the lower side (outer side) of the nasal vestibule, that is, the side close to the nose and mouth. The upper surface is located at the upper side (inner side) of the nasal vestibule, that is, the side away from the nose and mouth.

[0087] In a preferred embodiment, the upper surface is a mesh structure surface woven integrally with the peripheral wall of the stent body.

[0088] In another preferred embodiment, the upper surface is an open structure.

[0089] In a preferred embodiment, the lower surface is a mesh structure surface woven integrally with the peripheral wall of the stent body.

[0090] In another preferred embodiment, the lower surface is an open structure.

[0091] The coating comprises an upper coating and a lower coating, wherein the upper coating is compounded on the upper surface of the support body, and the lower coating is compounded on the lower surface of the support body.

[0092] The coating has a gradient filtering function and can filter fine particles. The upper coating and the lower coating are directly compounded on the stent body during molding.

[0093] In this embodiment, the upper covering film is composed of a fiber layer. Specifically, the upper covering film is made of PCL material by an electrostatic spinning method, and the average pore size is 50nm.

[0094] In this embodiment, the lower covering film is composed of two fiber layers. Specifically, the lower covering film is composed of a lower upper covering film and a lower lower covering film compounded in sequence from top to bottom. Among them:

[0095] The lower and upper covering films are made of PP material by melt-blowing method, and the average pore size is 2.5 μm.

[0096] The lower covering film is made of PP material by a spunbond method, and has an average pore size of 10 μm.

[0097] The pore sizes of the fiber layers of the lower-lower film, the lower-upper film, and the upper film decrease in sequence. The pore sizes of the fiber layers of the upper film decrease in sequence from the bottom surface of the lower film to the upper film, which not only achieves effective filtration of the inhaled air, but also does not significantly affect the ventilation rate.

[0098] According to tests, the filtration efficiency of the anti-infective nasal vestibule stent provided in this embodiment is 98.8%.

[0099] When in use, the nasal vestibule covering stent is placed in the nasal vestibule of the patient with tracheal stent placement. The gas inhaled into the human body through the nose is gradiently filtered through the fiber layers of the lower-lower covering, the lower-upper covering, and the upper covering. The filtered gas is clean and sterile.

[0100] Clinical trials have shown that patients with tracheal stent placement who wear the anti-infection nasal vestibule coated stent provided in this embodiment have obvious anti-infection function, and the chances of bronchial, bronchiolar and lung infections are greatly reduced.

[0101] Embodiment 3

[0102] Combination Figure 4 This embodiment provides a method for preparing an anti-infective nasal vestibule stent-cover, the method comprising the following steps:

[0103] Step S1: Weaving

[0104] Using a mold, a monofilament weaving method is used to form a stent, wherein the shape and size of the stent match the nasal vestibule;

[0105] Step S2: Finalization

[0106] The shape of the stent is fixed by heat setting, so as to obtain a stent body with good shape memory performance and a shape and size matching the shape of the nasal vestibule;

[0107] Step S3: Lamination

[0108] A micro-nano fiber molding method is adopted to directly mold a coating on the upper surface and the lower surface of the stent body, respectively, to obtain an infection-resistant nasal vestibule coating stent.

[0109] Embodiment 4

[0110] This embodiment provides a method for preparing an anti-infective nasal vestibule stent-cover, the method comprising the following steps:

[0111] Step S1: Weaving

[0112] Using a mold, a monofilament weaving method is used to form a stent, wherein the shape and size of the stent match the nasal vestibule;

[0113] Step S2: Finalization

[0114] The shape of the stent is fixed by heat setting, so as to obtain a stent body with good shape memory performance and a shape and size matching the shape of the nasal vestibule;

[0115] Step S3: Lamination

[0116] A micro-nano fiber molding method is adopted to directly mold a coating on the upper surface and the lower surface of the stent body, respectively, and drugs are loaded onto the coating to obtain an anti-infection nasal vestibule coating stent.

[0117] Embodiment 5

[0118] This embodiment provides a method for preparing an anti-infective nasal vestibule stent-cover, the method comprising the following steps:

[0119] Step S1: Weaving

[0120] Using a mold, a monofilament weaving method is used to form a stent, wherein the shape and size of the stent match the nasal vestibule;

[0121] Step S2: Finalization

[0122] The shape of the stent is fixed by heat setting, so as to obtain a stent body with good shape memory performance and a shape and size matching the shape of the nasal vestibule;

[0123] Step S3: Lamination

[0124] The drug is pre-loaded into the material, and then the drug-loaded material is formed into a coating directly on the upper surface and the lower surface of the stent body using a micro-nano fiber molding method to obtain an anti-infection nasal vestibule coated stent.

[0125] Embodiment 6

[0126] This embodiment provides a method for preparing an anti-infective nasal vestibule stent-cover, the method comprising the following steps:

[0127] Step S1: Weaving

[0128] Using a mold, a monofilament weaving method is used to form a stent, wherein the shape and size of the stent match the nasal vestibule;

[0129] Step S2: Finalization

[0130] Fixing the shape of the stent by heat setting to obtain a stent body with good shape memory performance and a shape and size matching the shape of the nasal vestibule; coating / grafting drugs on the stent body;

[0131] Step S3: Lamination

[0132] A micro-nano fiber molding method is adopted to directly mold a coating on the upper surface and the lower surface of the stent body, respectively, to obtain an infection-resistant nasal vestibule coating stent.

[0133] Embodiment 7

[0134] This embodiment provides a method for preparing an anti-infective nasal vestibule stent-cover, the method comprising the following steps:

[0135] Step S1: Weaving

[0136] Pre-coating / grafting drugs onto monofilaments, and then using a mold to weave the monofilaments loaded with drugs into a stent, wherein the shape and size of the stent match the nasal vestibule;

[0137] Step S2: Finalization

[0138] Fixing the shape of the stent by heat setting to obtain a stent body with good shape memory performance and a shape and size matching the shape of the nasal vestibule; coating / grafting drugs on the stent body;

[0139] Step S3: Lamination

[0140] A micro-nano fiber molding method is adopted to directly mold a coating on the upper surface and the lower surface of the stent body, respectively, and drugs are loaded onto the coating to obtain an anti-infection nasal vestibule coating stent.

[0141] It should be understood that the directional terms such as up, down, left, right, front, back, front, back, top, bottom, etc. mentioned or may be mentioned in this specification are defined relative to the structures shown in the drawings. They are relative concepts and may change accordingly according to different positions and different usage conditions. Therefore, these or other directional terms should not be interpreted as restrictive terms.

[0142] The above is only a preferred embodiment of the present application, and is not any formal or substantial limitation to the present application. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the method of the present application, and these improvements and supplements should also be regarded as the protection scope of the present application. Any technician familiar with this profession can make some changes, modifications and evolutions of the technical content disclosed above without departing from the spirit and scope of the present application, which are equivalent embodiments of the present application; at the same time, any changes, modifications and evolutions of any equivalent changes made to the above embodiments based on the substantial technology of the present application are still within the scope of the technical solution of the present application.

Claims

1. An infection-resistant nasal vestibule stent, characterized in that: The nasal vestibule stent comprises: A stent body, wherein the shape and size of the stent body match the shape of the nasal vestibule; Lamination; The coating is composited on the stent body; The support body includes an upper surface and a lower surface, and the coating includes an upper coating and a lower coating, wherein the upper coating is compounded on the upper surface of the support body, and the lower coating is compounded on the lower surface of the support body; the upper coating and the lower coating are respectively composed of at least one fiber layer, and the pore size of the fiber layer decreases gradually from the lowermost layer of the lower coating to the uppermost layer of the upper coating.

2. The infection-resistant nasal vestibule stent according to claim 1, characterized in that: The stent body is a mesh structure formed by weaving and shaping shape memory wires.

3. The infection-resistant nasal vestibule stent according to claim 2, characterized in that: The shape memory wire is a metal wire or a polymer wire.

4. The infection-resistant nasal vestibule stent graft according to claim 1, characterized in that: The stent body and / or the covering film are loaded with drugs.

5. The infection-resistant nasal vestibule stent graft according to claim 3, characterized in that: The diameter of the metal wire is 0.01-0.5 mm; The diameter of the polymer filament is 0.05-0.5 mm; The metal wire is one or more of stainless steel wire, nickel wire, titanium wire, cobalt wire, tungsten wire and alloy wires thereof; The polymer yarn is one or more of PP, PE, PGA, PGLA, PPDO, PCL, PLA, PGCL, PVA and composite yarns thereof.

6. A method for preparing the infection-resistant nasal vestibule stent-cover as claimed in claim 1, characterized in that: The steps are: Using a mold, a monofilament weaving method is used to form a bracket, wherein the shape and size of the bracket match the nasal vestibule; The shape of the stent is fixed by heat setting, so as to obtain a stent body having a shape memory function and a shape and size matching the morphology of the nasal vestibule; A micro-nano fiber molding method is adopted to directly mold a coating on the upper surface and the lower surface of the stent body to obtain a nasal vestibule coating stent.

7. The method for preparing the infection-resistant nasal vestibule stent-cover according to claim 6, characterized in that: The stent body and / or the covering film are loaded with drugs; The method for loading drugs on the film comprises: After the film is formed, the drug is loaded onto the film; or The drug is pre-loaded into the material, and then the drug-loaded material is directly formed into a coating on the upper surface and the lower surface of the stent body by using a micro-nano fiber molding method; The method for loading drugs on the stent body comprises: After the stent body is woven and shaped, coating / grafting drugs on the stent body; or The drug is pre-coated / grafted onto the monofilaments, and then the monofilaments loaded with the drug are woven into a stent.

8. An application of the infection-proof nasal vestibule stent graft according to any one of claims 1 to 5, characterized in that: Use in the preparation of a device for preventing or treating bronchial infection caused by tracheal stent placement or artificial trachea transplantation.

9. An application of the infection-proof nasal vestibule stent graft according to any one of claims 1 to 5, characterized in that: Use in the preparation of a device for preventing or treating bronchiolar infection caused by tracheal stent placement or artificial trachea transplantation.

10. An application of the infection-proof nasal vestibule stent graft according to any one of claims 1 to 5, characterized in that: Application in the preparation of a device for preventing or treating lung infection caused by tracheal stent placement or artificial trachea transplantation.

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