A solid-liquid two-phase gel stirring filling system

Abstract

The present invention discloses a solid-liquid two-phase gel stirring and filling system. The gel is stored in a gel container, the lower part of the stirring paddle extends into the gel container, and the driving motor drives the stirring paddle to rotate to stir the gel in the gel container, so that the gel in the gel container is fully mixed and evenly mixed. The positioning needle seat is used to clamp the needle filling module, and the lifting driver can drive the positioning needle seat to move up and down. Each filling needle of the needle filling module should be inserted into the microcolumn of the microcolumn gel reagent card; the pumping device is started, and the pumping device drives the gel in the gel delivery pipeline to move, and the gel is sent from the gel container through the gel delivery pipeline to the needle filling module respectively, and is discharged from each filling needle into the microcolumn gel reagent card to complete the filling process. In this process, the stirring, pumping, and filling of the gel cooperate with each other to automatically complete the filling of the gel, improve the efficiency, and prevent the gel from spilling during the transfer process.

Description

Technical Field

[0001] The invention relates to the technical field of gel production, and further to a solid-liquid two-phase gel stirring and filling system. Background Art

[0002] Six-microcolumn or eight-microcolumn reagent cards are often used in medicine. The filling material is dextran gel with or without antibodies. The relevant tests are performed by using the property that the gaps between the gels only allow free red blood cells to pass through.

[0003] In order to maintain the uniformity of the gel and prevent it from precipitating and condensing, shaking on a shaker is often used, but the uniformity is not ideal. In the production process of the prior art microcolumn gel reagent card, a multi-step filling method is used to fill the gel separately. One process can be filled before the next process can be continued. This is not only inefficient, but also when filling the gel at the bottom of the reagent card, there will be less liquid, no liquid, and the liquid in the filling needle will solidify and precipitate. Some use a gel recovery box to add gel to the recovery box during non-filling time, but the gel is easy to evaporate and be contaminated, resulting in waste and increased production costs. Some use a front-suction and front-discharge filling method, that is, the gel is only sucked into the lower half of the filling needle by a filling pump and then filled. Although this can solve the problems of less liquid, no liquid, and gel precipitation and condensation, the filling needle needs to move linearly or rotationally to take samples and then fill. The slow filling speed makes it difficult to meet the company's production capacity requirements.

[0004] For those skilled in the art, how to automatically and efficiently achieve the stirring, conveying and filling of gel is a technical problem that needs to be solved at present. Summary of the invention

[0005] The present invention provides a solid-liquid two-phase gel stirring and filling system, which can automatically complete stirring, conveying and filling, and improve production efficiency. The specific scheme is as follows:

[0006] A solid-liquid two-phase gel stirring and filling system, comprising a stirring device, a pumping device and a filling device;

[0007] The stirring device comprises a gel container, a stirring paddle and a driving motor, wherein the gel container stores gel, the lower portion of the stirring paddle extends into the gel container, and the driving motor drives the stirring paddle to rotate to stir the gel in the gel container;

[0008] The filling device includes a lifting drive and a positioning needle seat, the positioning needle seat is used to clamp the filling needle module, and the lifting drive can drive the positioning needle seat to move up and down so that the filling needle is inserted into the microcolumn of the microcolumn gel reagent card;

[0009] Each filling needle on the needle filling module is connected to the gel container via a glue delivery pipeline, and the pumping device is arranged on the glue delivery pipeline to pump the glue in the gel container to the needle filling module.

[0010] Optionally, at least two groups of the gel container and the stirring paddle are provided, and the stirring paddle and the driving motor are driven by a belt, a chain or a gear, and the stirring paddle can drive the stirring paddle of the next stage to rotate.

[0011] Optionally, the stirring paddle comprises a transmission shaft, a hollow shaft and a driven pulley, the transmission shaft is inserted into the inner cavity of the hollow shaft, and the driven pulley is circumferentially fixed to the hollow shaft;

[0012] The transmission shaft can move axially relative to the hollow shaft, and blades are arranged at the lower part of the transmission shaft.

[0013] Optionally, the hollow shaft is mounted on the bearing seat via at least two rotary bearings.

[0014] Optionally, the transmission shaft and the hollow shaft are connected via a flat key or a spline; the hollow shaft and the driven pulley are connected via a flat key or a spline;

[0015] A fixed limiting ring is detachably fixedly arranged on the transmission shaft, and the lower surface of the fixed limiting ring contacts the bearing seat to realize axial limiting.

[0016] Optionally, the driven pulley or the hollow shaft is radially movably installed with a ball plunger, the ball plunger includes a movable inner core and a fixed outer shell, the fixed outer shell is fixed to the hollow shaft, the movable inner core can move radially, an elastic member is arranged between the movable inner core and the fixed outer shell, the movable inner core is subjected to an elastic force toward the direction of the transmission shaft, and can be pushed in a positioning groove arranged on the transmission shaft to achieve axial positioning.

[0017] Optionally, the transmission shaft comprises an upper section and a lower section which are clamped together, and the blades are arranged on the lower section.

[0018] Optionally, the blades are arranged in at least two groups along the axial direction, and each group of the blades has an angle in the circumferential direction.

[0019] Optionally, the filling device includes a guide plate slidably mounted on the positioning needle seat, and the filling needle on the filling needle module can pass through the guide plate; the guide plate protrudes downward to provide a positioning sleeve, and the positioning sleeve can be inserted into the microcolumn on the microcolumn gel reagent card to achieve circumferential adjustment.

[0020] Optionally, at least two guide shafts are vertically arranged on the upper edge of the guide plate, and the guide shafts are inserted into the positioning needle seat.

[0021] Optionally, a return spring is arranged between the guide shaft and the positioning needle seat, and the return spring can apply a downward elastic force to the guide shaft.

[0022] Optionally, a hose arranging block is arranged on the upper part of the positioning needle seat, and each filling needle of the needle filling module corresponds to a through hole on the hose arranging block for the glue delivery pipeline to pass through.

[0023] Optionally, identification marks are engraved or etched on the surface of the hose sorting block, and each of the identification marks corresponds to distinguishing the glue delivery pipeline connected to a filling needle.

[0024] Optionally, the pumping device includes a filling motor, a filling pump head and a grating sensor, and the grating sensor is used to detect the number of rotations of the filling motor.

[0025] Optionally, the gel container is provided with a tank cover, and the tank cover is connected to an automatic liquid replenishing system to cooperate with a liquid level sensor in the gel container to replenish the gel.

[0026] Optionally, the filling motor is a variable frequency motor, and its rotation speed is adaptively adjusted according to the filling gel composition, viscosity, and residual amount of the gel to be filled.

[0027] Optionally, a liquid dispenser is provided at the liquid outlet at the bottom of the gel container, and the liquid dispenser can transport gel to at least two groups of the filling devices.

[0028] Optionally, the gel container is a borosilicate container; the dispenser is a 304 or 306L stainless steel joint; the inner surface of the gel container, the outer surface of the stirring paddle, and the inner surface of the dispenser have a smooth transition without dead angles.

[0029] The present invention provides a solid-liquid two-phase gel stirring and filling system, wherein gel is stored in a gel container, the lower part of a stirring paddle extends into the gel container, and a driving motor drives the stirring paddle to rotate, stirring the gel in the gel container, so that the gel in the gel container is fully and evenly mixed. A positioning needle seat is used to clamp a needle filling module, and a lifting driver can drive the positioning needle seat to move up and down, and each filling needle of the needle filling module corresponds to a microcolumn of a microcolumn gel reagent card; the pumping device is started, and the pumping device drives the gel in the gel delivery pipeline to move, and the gel is respectively sent from the gel container to the needle filling module through the gel delivery pipeline, and is discharged from each filling needle into the microcolumn gel reagent card to complete the filling process. In this process, the stirring, pumping, and filling of the gel cooperate with each other, and the filling of the gel is automatically completed, which improves the efficiency and can prevent the gel from spilling during the transfer process. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 This is a schematic diagram of the overall structure of the solid-liquid two-phase gel stirring and filling system provided by the present invention;

[0032] Figure 2 It is a structural schematic diagram of a stirring device;

[0033] Figure 3 It is a structural schematic diagram of a filling device;

[0034] Figure 4 for Figure 2 A partial enlarged view of the dotted box in the middle;

[0035] Figure 5 for Figure 1 Section view at the AA fold line;

[0036] Figure 6 is a cross-sectional view of the upper section of the transmission shaft.

[0037] Figure 7 for Figure 6 Local longitudinal section along the XX direction;

[0038] Figure 8 for Figure 6 Longitudinal section view along the YY direction;

[0039] Fig. 9 for Figure 8 A schematic diagram of the cooperation between the positioning groove in the dotted line frame and the ball plunger;

[0040] Fig.10 It is the structural diagram of the lower section of the transmission shaft;

[0041] Fig.11 for Figure 1 Cross-section view at the middle BB.

[0042] The figure includes:

[0043] Stirring device 1, gel container 11, dispenser 111, stirring paddle 12, transmission shaft 121, avoidance groove 1211, clamping column 1212, sleeve 1213, hollow shaft 122, driven pulley 123, paddle 124, fixed limit ring 125, ball plunger 126, drive motor 13, pumping device 2, filling motor 21, filling pump head 22, grating sensor 23, filling device 3, lifting drive 31, positioning needle seat 32, filling needle module 33, guide plate 34, positioning shaft sleeve 341, guide shaft 342, reset spring 343, hose sorting block 35, glue delivery pipeline 4, bearing seat 5, rotating bearing 51, automatic liquid replenishment system 6. DETAILED DESCRIPTION

[0044] The core of the present invention is to provide a solid-liquid two-phase gel stirring and filling system, which can automatically complete stirring, conveying and filling, thereby improving production efficiency.

[0045] In order to enable those skilled in the art to better understand the technical solution of the present invention, the solid-liquid two-phase gel stirring and filling system of the present invention will be described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0046] The solid-liquid two-phase gel stirring and filling system of the present invention comprises a stirring device 1, a pumping device 2, a filling device 3 and other structures, and performs multiple steps of stirring, conveying and filling the gel. Figure 1 This is a schematic diagram of the overall structure of the solid-liquid two-phase gel stirring and filling system provided by the present invention.

[0047] Figure 2 The stirring device 1 is a schematic diagram of the structure of the stirring device 1; the stirring device 1 is used to stir the gel, and includes a gel container 11, a stirring paddle 12 and a driving motor 13. The gel container 11 stores the gel, and is a tank structure with an opening at the top, and a tank cover can be installed accordingly to reduce pollution. The gel is stored in the gel container 11, and the gel is stirred and mixed uniformly in the gel container 11 and then discharged for subsequent transfer and transportation.

[0048] The stirring paddle 12 is a mixing and stirring structure, and the lower part of the stirring paddle 12 extends into the gel container 11 and directly contacts the gel; the driving motor 13 is connected to the upper part of the stirring paddle 12, driving the stirring paddle 12 to rotate, and stirring the gel in the gel container 11 in a continuous circulation manner, so that the particles in the gel are kept evenly distributed. Compared with the traditional way of mixing gel by shaking, it can greatly improve the uniformity and efficiency of mixing.

[0049] Figure 3Schematic diagram of the structure of the filling device 3; the filling device 3 includes a lifting drive 31 and a positioning needle seat 32. The lifting drive 31 can be in the form of an electric cylinder, a hydraulic cylinder, a screw rod, etc., including a fixed part and a movable part. The fixed part is installed on the frame and remains fixed, and the movable part can move up and down relative to the fixed part. The positioning needle seat 32 is installed on the movable part and can move synchronously with the movable part.

[0050] The positioning needle seat 32 is used to clamp the needle filling module 33. The needle filling module 33 is detachably mounted on the positioning needle seat 32. Each needle filling module 33 is centrally mounted with multiple filling needles. Figure 1 The needle filling module 33 shown is provided with six filling needles in total, which can be applied to a six-microcolumn gel reagent card. If it is for an eight-microcolumn gel reagent card, eight filling needles can be provided accordingly, and the size of the positioning needle seat 32 is also changed accordingly.

[0051] The lifting drive 31 can drive the positioning needle seat 32 and the filling needle module 33 to move up and down, so that the filling needle moves downward and is inserted into the micro-column of the micro-column gel reagent card. After the insertion is in place, the filling process can be started. After the filling is completed, the filling needle moves upward and is removed from the micro-column of the micro-column gel reagent card.

[0052] Each filling needle on the needle filling module 33 is connected to the gel container 11 through the glue delivery pipe 4, and the gel in the gel container 11 delivers the glue to each filling needle on the needle filling module 33 through the glue delivery pipe 4; the pumping device 2 is arranged on the glue delivery pipe 4, provides power for the delivery of the glue, and pumps the glue in the gel container 11 to the needle filling module 33.

[0053] When the system is working, the driving motor 13 in the stirring device 1 drives the stirring paddle 12 to rotate, and the stirring paddle 12 continuously stirs the gel inside the gel container 11 to keep the gel in a uniformly mixed state; when filling is required, the microcolumn gel reagent card is placed under the needle filling module 33, and this process can be completed independently by another device. After it is in place, the lifting driver 31 drives the positioning needle seat 32 and the needle filling module 33 to move downward, and each filling needle on the needle filling module 33 is respectively inserted into the microcolumn gel reagent card, and the pumping device 2 is started, and the gel is transported to the microcolumn gel reagent card through the glue delivery pipeline 4; after the filling is completed, the lifting driver 31 drives the positioning needle seat 32 and the needle filling module 33 to move upward, and each filling needle is removed from the microcolumn gel reagent card, and the filled microcolumn gel reagent card can be taken out, and the next microcolumn gel reagent card is placed to repeat this process.

[0054] The solid-liquid two-phase gel stirring and filling system of the present invention can realize various processes such as stirring, pumping, and filling of the gel. Automatic filling can be achieved by continuously placing the microcolumn gel reagent card, thereby improving efficiency. In this process, there is no need to significantly translate the position of the filling needle module 33, which can prevent the gel from dripping from the filling needle.

[0055] On the basis of the above scheme, the stirring device 1 of the present invention is provided with at least two groups, each group of stirring devices 1 comprises the same structure, and a plurality of gel containers 11 are provided for stirring to realize batch production.

[0056] Each gel container 11 needs to be provided with a set of stirring paddles 12. There are two ways to transmit power to the stirring paddles 12, one is direct drive and the other is indirect drive; direct drive is the transmission between the stirring paddle 12 and the drive motor 13 through a belt, chain or gear; indirect drive is the stirring paddle 12 drives the next stirring paddle 12 to rotate through a belt, chain or gear.

[0057] For two or more groups of gel containers 11 and stirring paddles 12, at least one group of stirring paddles 12 is provided for each gel container 11. The above-mentioned direct drive and indirect drive may exist at the same time. One or more stirring paddles 12 are directly driven by the drive motor 13, and the other stirring paddles 12 are driven mutually.

[0058] Preferably, the stirring paddle 12 provided by the present invention includes a transmission shaft 121, a hollow shaft 122 and a driven pulley 123, Figure 4 As shown, Figure 2 The partial enlarged view of the dotted line frame in the figure; the transmission structure in the figure is a belt, and a driving pulley is set on the output shaft of the driving motor 13. The driving pulley transmits to the driven pulley 123 through the belt, and the driven pulley 123 further drives another driven pulley 123 to rotate. The hollow shaft 122 is a cylindrical structure with two ends through, and the transmission shaft 121 is inserted into the inner cavity of the hollow shaft 122. The transmission shaft 121 can move axially relative to the hollow shaft 122. The lower part of the transmission shaft 121 is provided with a blade 124, and the transmission shaft 121 can move in the up and down directions shown in the figure.

[0059] The driven pulley 123 is circumferentially fixed to the hollow shaft 122 , and the driven pulley 123 and the hollow shaft 122 rotate synchronously, and the hollow shaft 122 and the transmission shaft 121 rotate synchronously.

[0060] The bearing seat 5 is fixed on the frame and remains stationary. Two rotating bearings 51 are installed on the bearing seat 5. The hollow shaft 122 is installed on the bearing seat 5 through at least two rotating bearings 51. The hollow shaft 122 is fixedly assembled on the inner ring of the rotating bearing 51. The outer ring of the rotating bearing 51 is fixed on the bearing seat 5, and the friction during rotation is reduced by the bearing.

[0061] Specifically, the transmission shaft 121 and the hollow shaft 122 of the present invention are connected by a flat key or a spline; the hollow shaft 122 and the driven pulley 123 are connected by a flat key or a spline; Figure 5 for Figure 1In the cross-sectional view at the AA fold line, the transmission shaft 121 and the hollow shaft 122 are relatively fixed in the circumferential direction by a flat key A, and the hollow shaft 122 and the driven pulley 123 are relatively fixed in the circumferential direction by a flat key.

[0062] Since the transmission shaft 121 can move axially relative to the hollow shaft 122, the transmission shaft 121 needs to be kept at a specific height during normal operation. For this reason, the present invention provides a detachable fixed fixed stop ring 125 on the transmission shaft 121. The stop ring 125 can be arranged around the outer periphery of the transmission shaft 121 and protrude from the outer surface of the transmission shaft 121 to form an annular step. The lower surface of the fixed stop ring 125 contacts the top of the bearing seat 5 to achieve axial limit. The fixed stop ring 125 can be removed separately from the transmission shaft 121 and can change its axial position relative to the transmission shaft 121. The fixed stop ring 125 can be located at different positions to fix the transmission shaft 121 at different heights, and can be used in conjunction with gel containers 11 of different sizes and specifications for easy adjustment.

[0063] The fixed limiting ring 125 can be a circular ring with a notch, or can be formed by two semicircles assembled relative to each other, and is fixed to form a circular ring by bolt fastening, and is firmly fixed on the transmission shaft 121 .

[0064] The driven pulley 123 or the hollow shaft 122 is radially mounted with a ball plunger 126, Figure 5 As shown, the figure shows the structure of the ball plunger 126 installed on the driven pulley 123; the ball plunger 126 includes a movable inner core and a fixed outer shell, the fixed outer shell is a cylindrical through shell structure, the movable inner core is inserted inside, the movable inner core can slide relative to the fixed outer shell along the length direction, that is, move along the radial direction of the driven pulley 123; the fixed outer shell is fixedly installed on the hollow shaft 122, and an elastic member is provided between the fixed outer shell and the movable inner core, which is usually a spiral spring. The movable inner core is subjected to the elastic force of the elastic member, and the movable inner core of the ball plunger 126 is subjected to the elastic force toward the axis, and can be pressed against the positioning groove provided on the transmission shaft 121 to achieve axial positioning. The preferred solution is to provide an external thread on the outside of the fixed outer shell, and an internal thread is provided on the mounting hole of the driven pulley 123. The fixed outer shell is threaded and installed on the driven pulley 123, and a prismatic screwing structure is provided at one end of the fixed outer shell extending outward, and the fixed outer shell is screwed by a tool such as a wrench.

[0065] The inner end of the movable inner core can be pressed against the transmission shaft 121, and the outer end of the movable inner core can extend from the fixed outer shell. A pull ring or a handle is provided at the outer end of the movable inner core to facilitate applying an outward force to the movable inner core. In the absence of external force, the inner end of the movable inner core is pressed against the transmission shaft 121 due to the elastic force, and the movable inner core can be separated from the transmission shaft 121 when being pulled outward.

[0066] Figure 6 is a cross-sectional view of the upper section of the transmission shaft 121, Figure 7 for Figure 6 Local longitudinal section along the XX direction, Figure 8 for Figure 6 A longitudinal sectional view taken along the YY direction; in the figure, Ⅰ represents a keyway provided on the side wall of the transmission shaft 121, and Ⅱ represents a plurality of positioning grooves provided on the side wall of the transmission shaft 121, Fig. 9 for Figure 8 A schematic diagram of the cooperation between the positioning groove in the dotted line frame and the ball plunger 126.

[0067] By setting the ball plunger 126, when the transmission shaft 121 is pulled up to a certain height, the movable inner core of the ball plunger 126 is inserted into the positioning groove at the corresponding position of the outer surface of the transmission shaft 121, so that the transmission shaft 121 is kept at a higher position, so as to facilitate the cleaning of the gel container 11 below. After the operation is completed, the movable inner core of the ball plunger 126 is pulled outward to release the transmission shaft 121, or the transmission shaft 121 is directly pressed downward to unlock the movable inner core, and the transmission shaft 121 can move downward to reset and extend into the gel container 11.

[0068] For the convenience of operation, a ball head structure may be provided at the top of the transmission shaft 121 to facilitate hand holding.

[0069] The transmission shaft 121 includes an upper section and a lower section that are clamped together, the paddles 124 are arranged on the lower section, and the upper section is not provided with paddles; Fig.10 The structure diagram of the lower section of the transmission shaft 121 is shown. The structure of the interconnected parts between the upper section and the lower section is the same; the interconnected parts between the upper section and the lower section include a shunting groove 1211 and a clamping column 1212 respectively. The clamping column 1212 of the upper section is clamped into the shunting groove 1211 of the lower section, and the clamping column 1212 of the lower section is clamped into the shunting groove 1211 of the upper section. After being clamped together, a complete cylindrical structure is formed. After the upper section and the lower section are connected to each other, they cannot move relative to each other in the axial direction; a sleeve 1213 is set on the outer periphery of the cylinder formed by them, so that the upper section and the lower section cannot move relative to each other in the radial direction, and the upper section and the lower section are relatively fixed.

[0070] The blades 124 are arranged in at least two groups along the axial direction. Fig.10 In the structure shown, three groups of blades 124 are provided, namely, upper, middle and lower groups, and the radial angle between these three groups of blades is zero degree; in the present invention, preferably, each group of blades 124 has an angle in the circumferential direction, and the angles between each group are preferably evenly distributed. These specific embodiments should all be included in the protection scope of the present invention.

[0071] Combination Figure 3As shown, the filling device 3 includes a guide plate 34 slidably mounted on the positioning needle seat 32, and the filling needle on the filling needle module 33 can extend downward through the guide plate 34; a positioning sleeve 341 is protruding downward from the lower surface of the guide plate 34, and the positioning sleeve 341 can be inserted into the micro-column on the micro-column gel reagent card to achieve circumferential adjustment. The lower end size of the positioning sleeve 341 is slightly smaller, and the small corner is set to be rounded, which can facilitate accurate insertion.

[0072] At least two positioning sleeves 341 are provided, each positioning sleeve 341 surrounds a filling needle, and the filling needle is located at the central axis of the positioning sleeve 341. The shape of the outer surface of the positioning sleeve 341 is similar to the shape of the inner surface of the microcolumn on the microcolumn gel reagent card, and the lower end of the positioning sleeve 341 can extend into the inside of the microcolumn; during the descent process, if the position of the microcolumn gel reagent card is not completely aligned with the filling needle, the positioning sleeve 341 contacts the inner wall of the microcolumn gel reagent card to correct the position of the microcolumn gel reagent card, and when the filling needle is fully inserted, it is aligned with the center of each microcolumn.

[0073] Furthermore, in the present invention, at least two guide shafts 342 are vertically arranged on the guide plate 34, and the guide shafts 342 are guided and inserted into the positioning needle seat 32. Figure 3 As shown, the guide shaft 342 is located at both ends of the guide plate 34, and is vertically inserted into the guide groove of the positioning needle seat 32, and can move vertically along the guide groove.

[0074] A return spring 343 is provided between the guide shaft 342 and the positioning needle seat 32, and the return spring 343 can exert a downward elastic force on the guide shaft 342; Figure 3 As shown, the return spring 343 is a coil spring, which is mounted on the top periphery of the guide shaft 342. The lower end of the return spring 343 is against a stopper protruding from the outside of the guide shaft 342, and the upper end is in contact with the positioning needle seat 32. The return spring 343 generates a downward elastic force on the guide shaft 342, so that the guide shaft 342 remains in a low position.

[0075] When the lifting driver 31 drives the positioning needle seat 32 to descend, the guide plate 34 descends together. The guide plate 34 is first blocked by the microcolumn gel reagent card and cannot descend. The positioning needle seat 32 continues to descend. At this time, the return spring 343 is compressed, and the length of the filling needle exposed from the positioning sleeve 341 increases. When the filling needle approaches the bottom end of the microcolumn, it stops descending and starts filling; after completion, it rises in the opposite direction.

[0076] Preferably, a hose sorting block 35 is provided on the upper part of the positioning needle seat 32, and each filling needle of the filling needle module 33 corresponds to a through hole on the hose sorting block 35 for the glue delivery pipeline 4 to pass through. Through the through holes on the hose sorting block 35, each glue delivery pipeline 4 is neatly led out to prevent mutual entanglement.

[0077] Preferably, the present invention engraves or etches identification marks on the surface of the hose sorting block 35, and each identification mark corresponds to distinguishing the glue delivery pipe 4 connected to a filling needle. The identification marks can be in the form of 1, 2, 3, 4... or a, b, c, d..., etc., which is convenient for identifying and quickly distinguishing each glue delivery pipe 4 to prevent confusion.

[0078] On the basis of any of the above technical solutions and their mutual combinations, the pumping device 2 in the present invention includes a filling motor 21, a filling pump head 22 and a grating sensor 23. The filling motor 21 drives the filling pump head 22 to work. The filling pump head 22 can realize the ul-level precision filling of solid-liquid two-phase micro-column gel. The principle is the principle of a rotary plunger pump, which contacts the gel, sucks in and then discharges it. It needs to be cleaned before and after filling. The grating sensor 23 is used to detect the number of rotations of the filling motor 21 and control the pumping volume according to the number of rotations. In addition to realizing the micro-column filling of the gel reagent card, the solid-liquid two-phase gel stirring filling system of the present invention can also realize the withdrawal of the gel solution under certain circumstances, that is, the filling motor 21 rotates in the opposite direction to drive the filling pump head 22 to move, and the grating sensor 23 feeds back the motor rotation angular displacement.

[0079] Preferably, the solid-liquid two-phase gel stirring filling system of the present invention can realize an online or offline cleaning function: when the glue liquid is filled, purified water (distilled water) is added to the gel container 11, and the filling motor 21 drives the filling pump head 22 to move forward and reversely, which can realize the flushing (cleaning) and backwashing (backwashing) of the filling needle, glue delivery pipeline 4, filling pump head 22, dispenser 111, gel container 11, etc.

[0080] Combination Figure 1 As shown, the gel container 11 is provided with a tank cover to prevent external impurities from falling, and a handle can be provided on the upper surface of the tank cover for easy opening of the tank cover; the tank cover is connected to an automatic liquid replenishing system 6, and it is difficult to monitor the remaining amount of glue in the container at any time only by naked eyes, and the gel is replenished in conjunction with the liquid level sensor in the gel container 11. The liquid level sensor and the automatic liquid replenishing system 6 are both controlled by the PLC, and the liquid level sensor detects the remaining amount of glue and transmits feedback signal to the PLC. When the liquid level in the gel container 11 is lower than the minimum value, the automatic liquid replenishing system 6 is started to add additional gel to the gel container 11. When the liquid level in the gel container 11 reaches the maximum liquid level, the automatic liquid replenishing system 6 is controlled to stop replenishing gel.

[0081] The filling motor 21 of the present invention is a variable frequency motor, and its rotation speed is adaptively adjusted according to the stirring speed of the filling gel composition, viscosity, and the remaining amount of glue. When the remaining glue in the glass jar container is not much or is about to be exhausted, it is very easy to be mixed with air to form bubbles. Therefore, the filling motor 21 of the present invention is an adjustable speed motor, which can adaptively adjust the stirring speed according to the different filling gel components, different viscosities, and the remaining amount of glue in the container to achieve optimal control.

[0082] In combination with the above introduction, the present invention has two liquid level detection methods, one is to directly detect the liquid level of the gel container 11 by the liquid level sensor, and the other method is to calculate the remaining amount of glue in the container according to the number of pumping times of the filling pump head 22. The PLC adjusts the speed of the filling motor 21 according to the liquid level in the gel container 11.

[0083] The premise of the second method is that the container volume is fixed and it is filled to the maximum scale mark before each filling. Since the volume of glue liquid extracted by the filling pump each time is fixed, the remaining amount of glue liquid in the container can be calculated based on the number of filling times of the filling pump and fed back to the PLC. The PLC sends a signal to control and adjust the speed of the stirring motor.

[0084] Furthermore, the present invention provides a liquid distributor 111 at the liquid outlet at the bottom of the gel container 11, such as Fig.11 As shown, Figure 1 The cross-sectional view at BB in the middle shows the structure of the liquid distributor 111; the liquid distributor 111 can deliver gel to at least two groups of filling devices 3, and the inlet at the center of the liquid distributor 111 is connected to the outlet of the gel container 11. Fig.11 Two discharge ports are provided to discharge gel in the directions indicated by arrows respectively. Each discharge port is connected to a group of filling devices 3 through a glue delivery pipeline 4. Each group of filling devices 3 is powered by a corresponding set of pumping devices 2. A gel container 11 supplies gel to multiple groups of filling devices 3.

[0085] The gel container 11 is a borosilicate container; the dispenser 111 is a 304 or 306L stainless steel joint; the inner surface of the gel container 11, the outer surface of the stirring paddle 12, and the inner surface of the dispenser 111 are all structures with smooth transitions and no dead angles. The design of the above materials and structures can be easily cleaned and make sterilization more thorough.

[0086] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A solid-liquid two-phase gel stirring filling system, characterized in that: It comprises a stirring device (1), a pumping device (2) and a filling device (3); The stirring device (1) comprises a gel container (11), a stirring paddle (12) and a driving motor (13); the gel container (11) stores gel; the lower portion of the stirring paddle (12) extends into the gel container (11); and the driving motor (13) drives the stirring paddle (12) to rotate to stir the gel in the gel container (11); The filling device (3) comprises a lifting drive (31) and a positioning needle seat (32); the positioning needle seat (32) is used to clamp the filling needle module (33); the lifting drive (31) can drive the positioning needle seat (32) to move up and down so that the filling needle is inserted into the microcolumn of the microcolumn gel reagent card; Each filling needle on the needle filling module (33) is connected to the gel container (11) via a gel delivery pipeline (4); the pumping device (2) is arranged on the gel delivery pipeline (4) and is used to pump the gel liquid in the gel container (11) to the needle filling module (33); The filling device (3) comprises a guide plate (34) slidably mounted on the positioning needle seat (32), and the filling needle on the needle filling module (33) can pass through the guide plate (34); the guide plate (34) is provided with a positioning sleeve (341) protruding downward, and the positioning sleeve (341) can be inserted into the micro-column on the micro-column gel reagent card to achieve circumferential adjustment; At least two guide shafts (342) are vertically arranged on the guide plate (34), and the guide shafts (342) are guided and inserted into the positioning needle seat (32); A return spring (343) is provided between the guide shaft (342) and the positioning needle seat (32), and the return spring (343) is capable of applying a downward elastic force to the guide shaft (342); A hose arranging block (35) is arranged on the upper part of the positioning needle seat (32), and each filling needle of the filling needle module (33) corresponds to a through hole on the hose arranging block (35) for the glue delivery pipeline (4) to pass through.

2. The solid-liquid two-phase gel stirring and filling system according to claim 1, characterized in that: At least two groups of the gel container (11) and the stirring paddle (12) are provided, and the stirring paddle (12) and the driving motor (13) are driven by a belt, a chain or a gear, so that the stirring paddle (12) can drive the stirring paddle (12) of the next stage to rotate.

3. The solid-liquid two-phase gel stirring and filling system according to claim 2, characterized in that: The stirring paddle (12) comprises a transmission shaft (121), a hollow shaft (122) and a driven pulley (123); the transmission shaft (121) is inserted into the inner cavity of the hollow shaft (122), and the driven pulley (123) is circumferentially fixed to the hollow shaft (122); The transmission shaft (121) is capable of axially moving relative to the hollow shaft (122), and a paddle (124) is provided at the lower part of the transmission shaft (121).

4. The solid-liquid two-phase gel stirring and filling system according to claim 3, characterized in that: The hollow shaft (122) is mounted on the bearing seat (5) via at least two rotary bearings (51).

5. The solid-liquid two-phase gel stirring and filling system according to claim 4, characterized in that: The transmission shaft (121) and the hollow shaft (122) are connected via a flat key or a spline; the hollow shaft (122) and the driven pulley (123) are connected via a flat key or a spline; A fixed limiting ring (125) is detachably fixedly disposed on the transmission shaft (121), and a lower surface of the fixed limiting ring (125) contacts the bearing seat (5) to achieve axial limiting.

6. The solid-liquid two-phase gel stirring and filling system according to claim 5, characterized in that: The driven pulley (123) or the hollow shaft (122) is radially mounted with a ball plunger (126), the ball plunger (126) comprising a movable inner core and a fixed outer shell, the fixed outer shell being fixed to the hollow shaft (122), the movable inner core being capable of moving radially, an elastic member being arranged between the movable inner core and the fixed outer shell, the movable inner core being subjected to an elastic force in a direction toward the transmission shaft (121), and being capable of being pushed into a positioning groove arranged on the transmission shaft (121) to achieve axial positioning.

7. The solid-liquid two-phase gel stirring and filling system according to claim 3, characterized in that: The transmission shaft (121) comprises an upper section and a lower section which are clamped together, and the blade (124) is arranged on the lower section.

8. The solid-liquid two-phase gel stirring and filling system according to claim 3, characterized in that: The blades (124) are arranged in at least two groups along the axial direction, and each group of the blades (124) has an included angle in the circumferential direction.

9. The solid-liquid two-phase gel stirring and filling system according to claim 1, characterized in that: An identification mark is engraved or etched on the surface of the hose arrangement block (35), and each identification mark corresponds to and distinguishes the glue delivery pipeline (4) to which a filling needle is connected.

10. The solid-liquid two-phase gel stirring and filling system according to any one of claims 1 to 9, characterized in that: The pumping device (2) comprises a filling motor (21), a filling pump head (22) and a grating sensor (23), wherein the grating sensor (23) is used to detect the number of rotations of the filling motor (21).

11. The solid-liquid two-phase gel stirring and filling system according to claim 10, characterized in that: The gel container (11) is provided with a tank cover, and the tank cover is connected to an automatic liquid replenishing system (6) for replenishing gel in cooperation with a liquid level sensor in the gel container (11).

12. The solid-liquid two-phase gel stirring and filling system according to claim 11, characterized in that: The filling motor (21) is a variable frequency motor, and its rotation speed is adaptively adjusted according to the filling gel composition, viscosity, and residual amount of gel liquid to perform stirring speed adjustment.

13. The solid-liquid two-phase gel stirring and filling system according to claim 10, characterized in that: A liquid distributor (111) is provided at the liquid outlet at the bottom of the gel container (11), and the liquid distributor (111) is capable of conveying gel to at least two groups of the filling devices (3).

14. The solid-liquid two-phase gel stirring and filling system according to claim 13, characterized in that: The gel container (11) is a borosilicate container; the liquid dispenser (111) is a 304 or 306L stainless steel joint; the inner surface of the gel container (11), the outer surface of the stirring paddle (12), and the inner surface of the liquid dispenser (111) have a smooth transition without dead angles.

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