Sample analysis device and method thereof

Abstract

A sample analysis device and method thereof, wherein a first transport component (71) transports a reaction cup after sample loading to a first cache transfer position (77); a second transport component (73) transports the reaction cup in the first cache transfer position (77) to a reaction component (51), and transports the reaction cup in the reaction component (51) after sample incubation to a second cache transfer position (78); and a third transport component (75) transports the reaction cup in the second cache transfer position (78) to a measurement component (52).

Description

Technical Field

[0001] The present invention relates to a sample analysis device and a method thereof. Background Art

[0002] Sample analysis devices, such as biochemical analyzers, immunoassay analyzers, coagulation analyzers, and cell analyzers, are instruments used to analyze and measure samples. These devices typically add reagents to the sample and then measure the sample's characteristics, chemical composition, and concentration in a specific manner after the sample reacts with the reagents.

[0003] Improving the testing speed of sample analyzers is a goal pursued by researchers; miniaturization of sample analyzers is also a goal pursued by researchers. One approach to increasing the speed of sample analyzers is to add related components, such as multiple sample injection needles. However, adding these components increases the instrument's size, which conflicts with the goal of miniaturization. Therefore, resolving or balancing this conflict between increasing the speed and miniaturization of sample analyzers is the goal of the present invention. Summary of the Invention

[0004] The present invention mainly provides a sample analysis device and method, which are described in detail below.

[0005] According to the first aspect, an embodiment provides a sample analysis device, comprising:

[0006] chassis;

[0007] a reaction cup loading component, disposed in the housing, for supplying and carrying empty reaction cups to a predetermined location;

[0008] A sample injection component is provided in the housing and is used to dispatch the sample to be injected to the sample suction position;

[0009] A sample dispensing component is provided in the housing and is used to draw the sample from the sample aspiration position and discharge it into a reaction cup located at the sample addition position;

[0010] a reagent carrying component, disposed in the housing and having a plurality of positions for carrying reagent containers;

[0011] A reagent dispensing component is provided in the housing and is used to draw reagent from the reagent aspiration position and discharge it into a reaction cup at the reagent addition position;

[0012] A reaction component, disposed in the housing, for carrying a reaction cup and incubating the sample in the reaction cup;

[0013] a measuring component, disposed in the housing, for carrying a reaction cup and measuring the sample in the reaction cup; and

[0014] A first transfer component, a second transfer component, a third transfer component, a first cache transfer position, and a second cache transfer position; wherein:

[0015] The first transport component is used to transport the reaction cup after sample loading to the first buffer transfer position;

[0016] The second transport component is used to transport the cuvette in the first buffer transfer position to the reaction component, and to transport the cuvette in the reaction component after the sample incubation is completed to the second buffer transfer position;

[0017] The third transport component is used to transport the cuvette transferred in the second buffer to the measurement component.

[0018] According to a second aspect, an embodiment provides a method for a sample analysis device, the sample analysis device comprising a first transport component, a second transport component, a third transport component, a first cache transfer position, and a second cache transfer position; the method comprising:

[0019] Controlling the first transport component to transport the reaction cup after sample loading to the first buffer transfer position;

[0020] Controlling the second transport component to transport the cuvette in the first buffer to the incubation position;

[0021] Controlling the second transport component to transport the cuvette in which the sample incubation is completed in the incubation position to the second buffer transfer position;

[0022] The third transport component is controlled to transport the cuvette transferred from the second buffer to the measurement position.

[0023] According to a third aspect, an embodiment provides a computer-readable storage medium, comprising a program, wherein the program can be executed by a processor to implement the method described in any embodiment herein. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 is a schematic structural diagram of a sample analysis device according to an embodiment;

[0025] Figure 2 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0026] Figure 3 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0027] Figures 4(a) and 4(b) are schematic structural diagrams of reagent carrying components according to two embodiments;

[0028] Figure 5 A schematic structural diagram of a reagent carrying component according to another embodiment;

[0029] Figure 6 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0030] Figure 7 This is a schematic structural diagram of a reagent dispensing component according to an embodiment;

[0031] Figure 8 A schematic structural diagram of a reagent dispensing component according to another embodiment;

[0032] Figure 9 This is a schematic structural diagram of a reagent dispensing component according to another embodiment;

[0033] Figure 10 This is a schematic structural diagram of a reagent dispensing component according to another embodiment.

[0034] Figure 11 This is a schematic structural diagram of a sample analysis device according to another embodiment;

[0035] FIG12( a ) is a schematic structural diagram of a transfer component according to an embodiment, FIG12( b ) is a schematic structural diagram of a first transfer component according to an embodiment, FIG12( c ) is a schematic structural diagram of a second transfer component according to an embodiment, and FIG12( d ) is a schematic structural diagram of a third transfer component according to an embodiment;

[0036] Figure 13 This is a schematic structural diagram of a cup gripper according to an embodiment;

[0037] Figure 14 It is a structural schematic diagram of a sample analysis device according to yet another embodiment;

[0038] Figure 15 is a structural schematic diagram of a sample analysis device according to yet another embodiment;

[0039] Figure 16 A schematic structural diagram of a cleaning component according to an embodiment;

[0040] Figure 17 A schematic flow chart of a sample analysis method according to an embodiment;

[0041] Figure 18 A timing diagram of the actions of two reagent needles in the same group according to one embodiment;

[0042] Figure 19 A timing diagram of the two reagent needles in the same group according to another embodiment;

[0043] Figure 20 This is a timing diagram of the two reagent needles in the same group according to another embodiment;

[0044] Figure 21 This is a timing diagram of the two reagent needles in the same group according to another embodiment;

[0045] Figure 22 A method of a sample analysis device according to an embodiment of the present invention is provided. DETAILED DESCRIPTION

[0046] The present invention will be further described in detail below by means of specific embodiments in conjunction with the accompanying drawings. Similar elements in different embodiments are numbered with associated similar elements. In the following embodiments, many detailed descriptions are provided to enable the present invention to be better understood. However, those skilled in the art will readily appreciate that some of the features may be omitted under different circumstances, or may be replaced by other elements, materials, or methods. In some cases, some operations related to the present invention are not shown or described in the specification. This is to avoid the core of the present invention being overwhelmed by excessive descriptions, and for those skilled in the art, it is not necessary to describe these related operations in detail. They can fully understand the related operations based on the description in the specification and the general technical knowledge in the art.

[0047] In addition, the features, operations, or characteristics described in the specification may be combined in any appropriate manner to form various embodiments. Furthermore, the steps or actions in the method description may be reordered or adjusted in a manner readily apparent to those skilled in the art. Therefore, the various sequences in the specification and drawings are provided solely for the purpose of clearly describing a particular embodiment and are not intended to be mandatory, unless otherwise specified.

[0048] The serial numbers assigned to components herein, such as "first," "second," etc., are used solely to distinguish the objects being described and do not convey any sequential or technical meaning. The terms "connected" and "coupled" used in this disclosure include both direct and indirect connections (couplings) unless otherwise specified.

[0049] The structures of sample analysis devices according to some embodiments of the present invention are described below.

[0050] A sample analysis device is an instrument used to analyze and measure samples. Let's take a coagulation analyzer as an example to illustrate the test process of a sample analysis device. The test process of a coagulation analyzer is generally as follows: the sample and reagent are added to the reaction cup to prepare a reaction solution. After the reaction solution is mixed and incubated, the reaction cup is placed in a measuring component. The measuring component can irradiate the reaction solution in the reaction cup with multi-wavelength light and analyze it through coagulation method, immunoturbidimetry or chromogenic substrate method to obtain a coagulation reaction curve of the reaction solution over time, thereby further calculating the coagulation time or other coagulation-related performance parameters of the reaction solution. Since the coagulation analyzer is used to obtain a coagulation reaction curve of the reaction solution over time, in order to obtain correct measurement results, the time boundary conditions such as the addition time of the sample and reagent, and the incubation time need to be strictly set and controlled in the test process.

[0051] Please refer to Figure 1 , is a schematic diagram of the structure of a sample analysis device according to some embodiments of the present invention. The sample analysis device according to some embodiments of the present invention may include a housing 1, a cuvette loading component 10, a sample component 20, a sample dispensing component 30, a reagent carrying component 40, one or more reagent dispensing components 60, one or more processing units 50, and a scheduling component 70. It should be noted that, Figure 1 The example shown in FIG. 1 shows two reagent dispensing components 60 and two processing units 50. However, those skilled in the art will appreciate that this is merely an example and does not limit the number of reagent dispensing components 60 and processing units 50 to only two. The following describes each component of the sample analyzer in detail.

[0052] The housing 1 is the instrument housing of the sample analysis device. For example, it may be substantially rectangular or cube-shaped, and may function to house certain components of the sample analysis device. For example, in some embodiments, the housing 1 includes a first side 1a along a first direction and a second side 1b along a second direction.

[0053] The first direction and the second direction involved in this document, in some embodiments, these two directions, namely the first direction and the second direction, may be perpendicular to each other. For example, the first direction is the Y direction in the figure, and the second direction is the X direction in the figure.

[0054] The cuvette loading assembly 10 is used to supply and transport empty cuvettes. During operation, the sample analyzer continuously uses empty cuvettes to complete each test item. The sample analyzer adds samples and reagents to the empty cuvettes to prepare, incubate, and measure the reaction solution, thereby obtaining the test results for each item. The cuvette loading assembly 10 loads the empty cuvettes into a predetermined position. The sample dispensing mechanism draws the sample from the sample assembly 20 and discharges it into the empty cuvette at the predetermined position.

[0055] The sample component 20 is used to supply a sample rack carrying samples to be tested. In some embodiments, the sample component 20 can be disposed in the housing 1. The sample component 20 can be implemented in a variety of ways.

[0056] In one implementation of the sample component 20 , the sample component 20 may be a sample injection component 21 , which is used to dispatch a sample rack carrying samples to a sample aspiration position. Figure 2 As an example, the injection component 21 may include a loading area 21a, an injection channel 21b, and an unloading area 21c, wherein the injection channel 21b may be provided with a sample suction position 21d. In the figure, the X direction and the Y direction are perpendicular, the X1 direction and the X2 direction are opposite directions, and the Y1 direction and the Y2 direction are also opposite directions. The user can place the sample rack carrying the sample to be tested in the loading area 21a. The loading area 21a moves the sample rack in the Y1 direction in the figure to enter the injection channel 21b. The sample rack can move along the X1 direction in the injection channel 21b and pass through the sample suction position. The sample on the sample rack can be sucked by the sample dispensing component 30 when passing through the sample suction position. The sample rack then enters the unloading area 21c from the injection channel 21b along the Y2 direction. The user can take out the sample rack from the unloading area 21c. The sampling component 21 is more suitable for large-scale sample testing occasions, and the sampling component 21 can be set independently from the sample analysis device. When the sample analysis device needs to be connected to a test system in the form of an assembly line, the sampling component 21 can be directly removed.

[0057] In another implementation of the sample component 20 , the sample component 20 may be a sample placement area 22 , and the sample placement area 22 is used to place a sample rack carrying samples to be tested. Figure 3 For example, the sample placement area 22 can have multiple channels 22a, each of which can hold a sample rack. The user can push the sample rack into the channel 22a along the Y1 direction in the figure. The sample dispensing component 30 can sequentially aspirate the samples from the sample racks in each channel 22a. After all the samples in the sample racks have been aspirated, the user can pull the sample rack out of the channel 22a along the Y2 direction in the figure. The sample placement area 22 does not require the sample racks to be arranged, so it occupies a smaller volume, which helps reduce the size of the sample analyzer and is very beneficial for the miniaturization of the sample analyzer.

[0058] The sample dispensing component 30 is used to draw samples from the sample suction position and discharge them into the reaction cup located at the sample loading position. In some embodiments, the sample dispensing component 30 can be arranged in the housing 1. In some embodiments, the sample dispensing mechanism 30 may include a sample needle, and the sample needle is driven by a two-dimensional or three-dimensional driving mechanism to move in a two-dimensional or three-dimensional direction. In some embodiments, the sample needle may be one or more. In order to simplify the motion trajectory and reduce the volume and size of the sample analysis device, the sample suction position and the predetermined position to which the reaction cup loading component 10 loads the empty reaction cup can be designed to be on a straight line, for example, on a straight line along the first direction. In this way, the sample needle only needs to move back and forth between the sample suction position and the above-mentioned predetermined position in the first direction, which not only increases the movement speed of the sample needle, but also helps to reduce the size of the sample analysis device, which is very beneficial for the miniaturized design of the sample analysis device.

[0059] The reagent carrying component 40 is used to carry reagents. For example, the reagent carrying component 40 can have multiple positions for carrying reagent containers, and the reagent containers are used to carry reagents. Generally, the reagent carrying component 40 can provide functions such as refrigeration for the carried reagents, thereby ensuring the activity of the reagents. In some embodiments, the reagent carrying component 40 can be arranged in the housing 1. In some embodiments, the reagent carrying component 40 is arranged in a disc-shaped structure, which has multiple positions for carrying reagent containers. The reagent carrying component 40 can rotate and drive the reagent containers it carries to be transported, thereby rotating the reagent containers to the reagent suction position for the reagent dispensing component 60 to absorb the reagent - for example, the reagent carrying component 40 includes a first drive component for driving its rotation, and the first drive component drives the reagent carrying component 40 to rotate, and is used to rotate the reagent container to the reagent suction position. The reagent carrying component 40 arranged in a disc-shaped structure is described in detail below.

[0060] Please refer to Figure 4(a). In some specific embodiments, the reagent carrying component 40 is arranged in a disc-shaped structure, which has a plurality of positions for placing reagent cups 41. The reagent cups 41 each include one or more cavities for holding reagents required for project testing, and one reagent is placed in one cavity; the reagent carrying component 40 includes a first driving component for driving it to rotate, and the first driving component drives the reagent carrying component 40 to rotate, and is used to rotate the cavity of the reagent cup 41 containing the reagent required for the project to the corresponding reagent aspiration position. In one example, the reagent cup 41 includes at least a first cavity 41a for carrying a first reagent and a second cavity 41b for carrying a second reagent. For example, the reagent cup 41 includes at least a first cavity 41a for carrying a mixed reagent R1 and a second cavity 41b for carrying a trigger reagent R2; the reagent carrying component 40 includes a first reagent aspiration position and a second reagent aspiration position different from the first reagent aspiration position, and the first driving component drives the reagent carrying component 40 to rotate and drives the reagent cup 41 to rotate, so as to rotate the first cavity 41a of the reagent cup 41 to the first reagent aspiration position; the first driving component drives the reagent carrying component 40 to rotate and drives the reagent cup 41 to rotate, so as to rotate the second cavity 41b to the second reagent aspiration position.

[0061] Referring to FIG. 4( b ), in some specific embodiments, the reagent carrying component 40 is provided in a disc-shaped structure, having a plurality of positions for holding a first reagent container 42 for holding a first reagent, and a plurality of positions for holding a second reagent container 43 for holding a second reagent. The reagent carrying component 40 includes a first drive assembly for driving its rotation. The first drive assembly drives the reagent carrying component 40 to rotate and drives the first reagent container 42 to rotate, so as to rotate the first reagent container 42 to the first reagent aspiration position; the first drive assembly drives the reagent carrying component 40 to rotate and drives the second reagent container 43 to rotate, so as to rotate the second reagent container 43 to the second reagent aspiration position. In one example, the reagent carrying component 40 may include multiple circles of independently rotatable tracks. For example, the reagent carrying component 40 may include two circles of tracks—an inner circle and an outer circle track. The outer circle track may be provided with a plurality of positions for the first reagent container 42, and correspondingly, the inner circle track may be provided with a plurality of positions for the second reagent container 43. The inner circle and outer circle tracks are driven to rotate independently by the first drive assembly.

[0062] The above describes two types of reagent carrying components 40. For example, FIG4(a) is an example of placing a reagent cup 41, and FIG4(b) is an example of realizing the reagent carrying component 40 by multiple circles of independently rotatable tracks. It can be understood by those skilled in the art that these two methods can also be combined to realize the reagent carrying component 40 by multiple circles of independently rotatable tracks, and at least one circle of tracks or each circle of tracks has multiple positions for placing the reagent cup 41, for example Figure 5This is an example. The reagent carrying component 40 can include two circles of tracks - an inner circle and an outer circle track. Multiple positions for placing reagent cups 41 can be set on the outer circle track. Correspondingly, multiple positions for placing reagent cups 41 can also be set on the inner circle track. The inner circle and outer circle tracks are driven to rotate independently by the first driving component.

[0063] The above is a brief description of the reagent carrying component 40. During the working cycle, the reagent carrying component 40 can rotate and dispatch the corresponding reagents required for the test items to the corresponding reagent aspiration positions of the reagent dispensing component 60, for example, dispatching the first reagent to the first reagent aspiration position and dispatching the second reagent to the second reagent aspiration position.

[0064] The processing unit 50 is used to receive a cuvette containing a sample and process the sample in the cuvette. The sample here refers to a reaction solution composed of a sample and reagents. There can be one or more processing units 50.

[0065] Please refer to Figure 6 In some embodiments, the processing unit 50 has at least one reaction component 51 for incubating the sample, and the reaction component 51 is used to carry the reaction cup and incubate the sample in the reaction cup. In some embodiments, the reaction component 51 is rectangular and has multiple reaction cup placement positions. Generally, the reaction component 51 can heat the reaction liquid or sample in the reaction cup on each reaction cup placement position to incubate the sample, for example, heating the sample in the reaction cup and maintaining it at 37±0.5°C. The specific heating time and the heated temperature can be determined by the heating parameters corresponding to different test items. In some embodiments, the length direction of the reaction component 51 is set along the first direction, for example, along the Y direction in the figure.

[0066] In some embodiments, the processing unit 50 includes at least one measuring component 52 for measuring samples. The measuring component 52 is used to hold a cuvette and test the sample in the cuvette. In some embodiments, the measuring component 52 is rectangular and has multiple cuvette placement locations. Generally, the measuring component 52 can be configured with a detection unit (not shown) for each cuvette placement location, with each detection unit being used to test the sample in the cuvette in the corresponding cuvette placement location. In some embodiments, the longitudinal direction of the measuring component 52 is arranged along a second direction different from the first direction, such as the X direction in the figure.

[0067] In some embodiments, the reaction component 51 and the determination component 52 are disposed adjacently around the reagent carrying component 40. In some specific embodiments, the reaction component 51 and the determination component 52 are disposed along the first side 1a and the second side 1b, respectively, and adjacently around the reagent carrying component 40.

[0068] The rectangular reaction component 51 and the measuring component 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying component 40 in an adjacent manner, which can save space and reduce the size of the sample analysis device. It is also beneficial for the reagent carrying component 40 to interact with the reaction component 51 and the measuring component 52 through the reagent dispensing component 60.

[0069] In some embodiments, the sample unit 20, such as the sample injection unit 21, the cuvette loading unit 10, the reaction unit 51, and the assay unit 52 are arranged around the reagent carrying unit 40. The present application is centered around the reagent carrying unit 40, and the scheduling trajectory of the entire cuvette detection process is designed around the reagent carrying unit 40, which is novel and space-saving.

[0070] Each processing unit 50 can be configured with a corresponding reagent adding transfer position, for example, the reaction component 51 is configured with at least one incubation transfer position 51a for placing a reaction cup, and the number of incubation transfer positions 51a can be one or more; when the position of the incubation transfer position 51a for placing the reaction cup is set to 1, the incubation transfer position 51a can be set in a position-adjustable manner so that the reaction cup placed on the incubation transfer position 51a can correspond to the position of each reagent needle in the first reagent dispensing component (the first reagent dispensing component corresponds to the reaction component and adds reagents to the reaction cup in the reaction component) to receive the reagent dispensed by each reagent needle. In some embodiments, the incubation transfer position 51a is arranged between the reagent carrying component 40 and the reaction component 51. The measurement component 52 is configured with at least one measurement transfer position 52a for placing a reaction cup, and the number of measurement transfer positions 52a can be one or more; in some embodiments, the measurement transfer position 52a is arranged between the reagent carrying component 40 and the measurement component 52. When the position for placing the reaction cup in the measurement transfer position 52a is set to 1, the measurement transfer position 52a can be set in a position-adjustable manner so that the reaction cup placed on the measurement transfer position 52a can correspond to the position of each reagent needle in the second reagent dispensing component (the second reagent dispensing component corresponds to the measurement component and adds reagent to the reaction cup in the measurement component) to receive the reagent dispensed by each reagent needle.

[0071] Figure 6 What is shown is that the number of incubation transfer positions 51a is one, and each incubation transfer position 51a has two reaction cup placement positions, such as the first position and the second position for placing the reaction cup; the number of measurement transfer positions 52a is one, and each measurement transfer position 52a has two reaction cup placement positions, such as the third position and the fourth position for placing the reaction cup.

[0072] The reagent dispensing unit 60 is used to draw reagent from the reagent aspiration station and discharge it into a cuvette at the reagent addition station. For example, the reagent dispensing unit 60 can draw a first reagent from the first reagent aspiration station mentioned herein and discharge it into the cuvette; the reagent dispensing unit 60 can draw a second reagent from the second reagent station mentioned herein and discharge it into the cuvette. In some embodiments, the reagent dispensing unit 60 can be disposed within the housing 1.

[0073] The reagent dispensing component 60 can be implemented by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle, which is used to draw the reagent from the reagent carrying component 40 and discharge it into the reaction cup.

[0074] Regarding the number of reagent needles, in some embodiments, the reagent dispensing component 60 may include multiple reagent needles, each of which is configured to move independently of one another. Specifically, the reagent needles may be configured as follows: each processing unit 50 is configured with a set of reagent needles; the reagent needles are used to draw reagents from the reagent carrying component 40 and discharge them into the reaction cup of the corresponding processing unit 50, with each set of reagent needles comprising at least two reagent needles. For example, one set of reagent needles may be configured for the reaction component 51, and another set of reagent needles may be configured for the measurement component 52. In some specific embodiments, a first group of reagent needles can be configured for the reaction component 51, and the first group of reagent needles are arranged in a manner that moves in a straight line between the reagent aspiration position and the incubation transfer position 51a. The first group of reagent needles is used to aspirate reagents from the reagent aspiration position and discharge them into a reaction cup located at the incubation transfer position 51a, and the first group of reagent needles includes at least one reagent needle; similarly, a second group of reagent needles can be configured for the measurement component 52, and the second group of reagent needles are arranged in a manner that moves in a straight line between the reagent aspiration position and the measurement transfer position 52a, and the second group of reagent needles is used to aspirate reagents from the reagent aspiration position and discharge them into a reaction cup located at the measurement transfer position 52a, and the second group of reagent needles includes at least one reagent needle.

[0075] From the perspective of the number of reagent dispensing components 60, in some embodiments, the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50. Figures 1 to 3 These are all examples of this. Specifically, there may be two reagent dispensing components 60, with the reaction component 51 corresponding to one of the reagent dispensing components 60 and the measurement component 52 corresponding to the other. By configuring a reagent dispensing component 60 for each processing unit 50, the steps of the reagent addition process for each test item are decomposed, that is, each reagent dispensing component 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50. This allows for the division of labor for adding the corresponding reagent for the test item, which helps improve efficiency.

[0076] Next, the specific structure of the reagent dispensing unit 60 will be described.

[0077] Please refer to Figure 7 Each reagent dispensing component 60 includes a plurality of reagent needles 61 and a guide assembly 62 for guiding the plurality of reagent needles 61 to move linearly, and a second drive assembly 63 for driving the plurality of reagent needles 61 to move linearly along the guide assembly 62. The guide assembly 62 is arranged along the direction determined by the reagent aspirating position and the reagent adding intermediate transfer position of the processing unit 50 corresponding to the reagent dispensing component 60, so that the reagent needle 61 absorbs the reagent from the reagent aspirating position and discharges it into the reaction cup at the reagent adding intermediate transfer position of the processing unit 50 corresponding to the reagent dispensing component 60. For example Figure 7 The reagent dispensing component 60 on the left side of the center has a guide assembly 62 arranged along the direction determined by the reagent aspiration position and the incubation transfer position 51a of the reaction component 51, so that the reagent needle 61 of the reagent dispensing component 60 aspirates the reagent from the reagent aspiration position and discharges it into the reaction cup located at the incubation transfer position 51a; Figure 7 The reagent dispensing component 60 on the right side of the middle has a guide assembly 62 arranged along the direction determined by the reagent aspiration position and the determination transfer position 52a of the determination component 52, so that the reagent needle 61 of the reagent dispensing component 60 draws the reagent from the reagent aspiration position and discharges it into the reaction cup located at the determination transfer position 52a. In some embodiments, the number of second drive assemblies 63 of each reagent dispensing component 60 is equal to the number of reagent needles 61, and the independent driving force output ends of the multiple second drive assemblies 63 act on the multiple reagent needles 61 accordingly, so as to independently drive the multiple reagent needles 61 to move linearly between the reagent aspiration position and the reagent addition transfer position along the guide assembly 52. ​​For example Figure 7 The example shown in FIG is an example in which each reagent dispensing component 60 includes two reagent needles 61 , and each reagent needle 61 is independently driven by its own second driving assembly 63 .

[0078] There are many ways to implement the guide component 52, and a few are listed below.

[0079] Figure 8It is a schematic diagram of the side of the reagent dispensing component 60. In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a crossbeam 62a, and a plurality of guide members 62b arranged in parallel and along the length direction of the crossbeam 62a; the crossbeam 62a is arranged along the direction determined by the reagent aspiration position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are respectively slidably connected to the plurality of guide members 62b, so that the reagent needle 61 moves linearly along the guide members 62b between the reagent aspiration position and the reagent adding transfer position. In some embodiments, each reagent dispensing component 60 is provided with two reagent needles 61; each reagent dispensing component 60 is provided with two guide members 62b, and both guide members 62b are linear guides; the two linear guides are respectively arranged on both sides of the crossbeam 62a along the long axis direction of the crossbeam 62a—— Figure 8 What is shown is a schematic diagram of one side of the beam 62a, and the structure on the other side reveals a reagent needle 61; the two above-mentioned reagent needles 61 are respectively arranged on the linear guide rails on both sides of the beam 62a, and are slidably connected to the linear guide rails; the reagent needle 61 moves linearly along the linear guide rails on which it is located between the reagent aspiration position and the reagent addition transfer position.

[0080] This is an embodiment of implementing a reagent dispensing component by respectively setting a reagent needle on both sides of a beam. In other embodiments, a reagent dispensing component can also be implemented by two parallel beams, each beam being provided with only one reagent needle, as described in detail below.

[0081] Please refer to Figure 9 and Figure 10 In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a plurality of parallelly arranged beams 62a, and a plurality of guide members 62b respectively arranged on the plurality of the above beams 62a and arranged along the length direction of the above beams 62a; the plurality of the above beams 62a are arranged along the direction determined by the reagent aspiration position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are respectively slidably connected to the plurality of guide members 62b, so that the reagent needle 61 moves linearly along the guide members 62b between the reagent aspiration position and the reagent adding transfer position. In some embodiments, the multiple guide members 62b of each reagent dispensing component 60 are linear guides, and the multiple linear guides are respectively arranged along the long axis direction of the multiple beams 62a; the multiple reagent needles 61 are respectively arranged on the linear guides of the multiple beams 62a and are slidably connected to the linear guides; the reagent needles 61 move linearly between the reagent aspiration position and the reagent addition transfer position along the linear guides on which they are located.

[0082] In some embodiments, the crossbeam 52 a of the guide assembly 52 in each reagent dispensing component 60 is fixedly disposed above the reagent aspirating position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60 .

[0083] The reagent dispensing component 60 realizes the linear motion of multiple needles through the crossbeam structure. The movement trajectory of the reagent needle 61 does not take up too much space and minimizes the interference with the layout of other components, making the structure of the sample analysis device more compact, which is very conducive to the miniaturization design of the sample analysis device.

[0084] In some embodiments, the linear motion trajectories of the reagent needles 61 of different reagent dispensing components 60 do not intersect with each other, which prevents the movements of the reagent needles 61 of different reagent dispensing components 60 from interfering with each other, thereby improving the test speed.

[0085] In some embodiments, there is at least one processing unit 50, and its reagent transfer position includes the same number of reaction cup placement positions as the reagent needles 61 of the reagent dispensing component 60 corresponding to the processing unit 50. Figure 6 In the example, the reagent adding transfer position of the reaction component 51 is the incubation transfer position 51a in the figure, and the incubation transfer position 51a can place two reaction cups; the number of reagent needles 61 of the reagent dispensing component 60 corresponding to the reaction component 51 is two. Figure 6 In the figure, the reagent transfer position of the measuring component 52 is the measuring transfer position 52a in the figure, and the measuring transfer position 52a can accommodate two reaction cups; the number of reagent needles 61 of the reagent dispensing component 60 corresponding to the measuring component 52 is two. In some embodiments, the number of the reagent aspiration positions is the same as the number of the reagent needles. For example Figure 6 There are two reagent dispensing components 60, each with two reagent needles 61, resulting in four reagent aspiration stations. The number of reagent needles matches the number of reagent addition stations, allowing each needle to clearly divide its work and add reagent to the cuvette at its respective reagent addition station, which helps improve testing speed.

[0086] In some embodiments, the reagent needles 61 in the same reagent dispensing component 60 are used to draw the same type of reagent. For example, the reagent needles 61 in the reagent dispensing component 60 corresponding to the reaction component 51 are all used to draw the first reagent, while the reagent needles 61 in the reagent dispensing component 60 corresponding to the measurement component 52 are all used to draw the second reagent. Different reagent dispensing components 60 are used to draw different reagents, which provides clear division of labor among the reagent dispensing components 60 and helps improve testing speed.

[0087] In some embodiments, each reagent needle 61 of the reagent dispensing unit 60 is provided with a heating component (not shown) for heating the reagent drawn by the reagent needle. Since each reagent dispensing unit 60 includes multiple reagent needles 61, for example, two reagent needles, each reagent needle 61 is further provided with a heating component. Since there are two reagent needles 61, each reagent needle 61 has sufficient time, for example, doubled time, to heat the drawn reagent while maintaining the original speed. Thus, when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already close to the predetermined temperature, i.e., the reagent has been fully preheated.

[0088] The above is a description of the reagent dispensing component 60. The following takes the case where there are two processing units 50, specifically the reaction component 51 and the measurement component 52, as an example to explain the coordination relationship and corresponding structure between the reagent dispensing component 60 and the processing unit 50.

[0089] In some embodiments, the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component, and the reagent dispensing component 60 corresponding to the measurement component 52 is a second reagent dispensing component, which will be described in detail below.

[0090] In some embodiments, the first reagent dispensing component 60 includes a first crossbeam 6a and a first set of reagent needles. The first set of reagent needles includes at least a plurality of first reagent needles 61, for example, two. These plurality of first reagent needles 61 are mounted on the first crossbeam 62a and move linearly along the longitudinal axis of the first crossbeam 62a to draw the first reagent from the first reagent aspiration position and discharge it into a cuvette located in the incubation transfer position 51a. In some embodiments, the first crossbeam 62a is positioned along a direction defined by the first reagent aspiration position and the incubation transfer position 51a, and the first crossbeam 62a is fixedly positioned above the first reagent aspiration position and the incubation transfer position 51a.

[0091] In some embodiments, the first crossbeam 62a of the first reagent dispensing component 60 is provided as a single beam. The multiple first reagent needles 61 are arranged in parallel on this single beam 62a and move linearly along the long axis of the beam 62a. For example, in a first group of reagent needles having two first reagent needles 61, a linear guide is provided on each side of the first crossbeam 62a along its long axis. The two first reagent needles 61 are respectively provided on the linear guides on either side of the first crossbeam 62a. The first reagent needles 61 move linearly along their respective linear guides between the first reagent aspiration position and the incubation transfer position 51a. This is an embodiment of the first reagent dispensing component implemented by providing a first reagent needle on each side of a single first crossbeam.

[0092] In some embodiments, the number of first crossbeams 62a in the first reagent dispensing component 60 is equal to the number of the multiple first reagent needles 61 in the first group of reagent needles. Each of the first crossbeams 62a is provided with a first reagent needle 61, and the first crossbeams 62a are arranged parallel to each other. In some specific embodiments, the multiple first crossbeams 62a are each provided with a linear guide along their long axis, and the multiple first reagent needles 61 are respectively provided on the linear guides of the multiple first crossbeams 62a, allowing the first reagent needles 61 to move linearly between the first reagent aspiration position and the incubation transfer position 51a. This is an embodiment of the first reagent dispensing component by using multiple, for example, two, parallel first crossbeams, with only one first reagent needle provided on each first crossbeam.

[0093] In some embodiments, the first reagent dispensing component 60 also includes multiple driving mechanisms that independently drive multiple first reagent needles to perform linear motion, such as second driving components. The number of the multiple second driving components is equal to the number of the multiple first reagent needles, and the independent driving force output ends of the multiple second driving components act on the multiple first reagent needles respectively to drive the multiple first reagent needles to perform linear motion along the long axis direction of the first beam between the first reagent aspiration position and the incubation transfer position 51a.

[0094] Taking the incubation transfer position 51a in the above text as an example, which includes the first position and the second position for placing the reaction cup, then in the example where the first reagent dispensing component 60 has two first reagent needles 61, one of the first reagent needles 61 moves linearly along the first beam 62a between the first reagent aspiration position and the first position, and the other first reagent needle 61 moves linearly along the first beam 62a between the first reagent aspiration position and the second position.

[0095] In some embodiments, the first reagent dispensing component 60 further includes a first Z-direction drive assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move in the vertical direction. The number of the first Z-direction drive assemblies 64 is the same as the number of the first reagent needles 61 in the first group of reagent needles. The first Z-direction drive assemblies 64 each include: a first Z-direction guide 64a for guiding the first reagent needles 61 to move in the vertical direction, and a first Z-direction drive 64b for driving the first reagent needles to move along the first Z-direction guide. The first reagent needle 61 is slidably connected to the first crossbeam 62a via the first Z-direction guide 64a and the first Z-direction drive 64b, so that the first reagent needle 61 can move vertically relative to the first crossbeam 62a under the drive of the first Z-direction drive 64b. It will be understood by those skilled in the art that when the reagent needle performs reciprocating linear motion, it needs to move in the vertical direction when reaching each position to complete operations such as aspirating and discharging the reagent.

[0096] In some embodiments, the first reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked therein.

[0097] The above is a description of the first reagent dispensing unit 60 . Next, the second reagent dispensing unit 60 will be described.

[0098] The second reagent dispensing assembly 60 includes a second crossbeam 62a and a second set of reagent needles. The second set of reagent needles includes at least a plurality of second reagent needles 61, for example, two. These plurality of second reagent needles 61 are mounted on the second crossbeam 62a and move linearly along the longitudinal axis of the second crossbeam 62a to draw the second reagent from the second reagent aspiration position and discharge it into a cuvette located in the measurement transfer position 52a. In some embodiments, the second crossbeam 62a is positioned along a direction defined by the second reagent aspiration position and the measurement transfer position 52a, and the second crossbeam 62a is fixedly positioned above the second reagent aspiration position and the measurement transfer position 52a.

[0099] In some embodiments, the second reagent dispensing component 60 has a single second crossbeam 62a, and the multiple second reagent needles 61 are arranged in parallel on this single second crossbeam 62a, moving linearly along the long axis of the second crossbeam 62a. For example, in a second group of reagent needles comprising two first reagent needles 61, a linear guide is provided on each side of the second crossbeam 62a along its long axis. The two second reagent needles 61 are respectively arranged on the linear guides on either side of the second crossbeam 62a, and the second reagent needles 61 move linearly along their respective linear guides between the second reagent aspiration position and the measurement transfer position 52a. This is an embodiment of the second reagent dispensing component implemented by providing a second reagent needle on each side of a single second crossbeam.

[0100] In some embodiments, the number of second crossbeams 62a in the second reagent dispensing component 60 is equal to the number of the plurality of second reagent needles 61 in the second group of reagent needles. Each second crossbeam 62a is provided with a second reagent needle 61, and pairs of second crossbeams 62a are arranged parallel to each other. In some specific embodiments, each of the plurality of second crossbeams 62a is provided with a linear guide along its longitudinal axis, and the plurality of second reagent needles 61 are respectively provided on the linear guides of the plurality of second crossbeams 62a, allowing the second reagent needles 61 to move linearly between the second reagent aspiration position and the measurement transfer position 52a. This is an embodiment of the second reagent dispensing component by using multiple, for example, two, parallel second crossbeams, each provided with only one second reagent needle.

[0101] In some embodiments, the second reagent dispensing component 60 further includes multiple drive mechanisms, such as third drive assemblies, that are distinct from the second drive assembly and independently drive the plurality of second reagent needles for linear motion. The number of third drive assemblies is equal to the number of the plurality of second reagent needles, and the plurality of third drive assemblies each independently outputs a driving force to act on the plurality of second reagent needles to drive the plurality of second reagent needles for linear motion along the longitudinal axis of the second beam between the second reagent position and the assay transfer position. The second and third drive assemblies may have the same structure.

[0102] Taking the example of the transfer position 52a in the above measurement including the third position and the fourth position for placing the reaction cup, in the example where the second reagent dispensing component 60 has two second reagent needles 61, one of the second reagent needles 61 moves linearly along the second beam 62a between the second reagent aspiration position and the third position, and the other second reagent needle 61 moves linearly along the second beam 62a between the second reagent aspiration position and the fourth position.

[0103] In some embodiments, the second reagent dispensing component 60 also includes a second Z-direction drive assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction respectively, and the number of the second Z-direction drive assemblies 64 is the same as the number of the second reagent needles 61 in the second group of reagent needles; the second Z-direction drive assemblies 64 each include: a second Z-direction guide 64a for guiding the second reagent needle 61 to move in the vertical direction, and a second Z-direction drive 64b for driving the second reagent needle 61 to move along the second Z-direction guide 64a; the second reagent needle 61 forms a sliding connection with the second beam 62a through the second Z-direction guide 64a and the second Z-direction drive 64b, so that the second reagent needle 61 can move in the vertical direction relative to the second beam 62a under the drive of the second Z-direction drive 64b.

[0104] In some embodiments, the second reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent absorbed therein.

[0105] In some embodiments, the linear motion trajectory of the multiple first reagent needles 61 of the first reagent dispensing component 60 between the first reagent aspiration position and the incubation transfer position 51a is a first motion trajectory; the linear motion trajectory of the multiple second reagent needles 61 of the second reagent dispensing component 60 between the second reagent aspiration position and the measurement transfer position 52a is a second motion trajectory; wherein the first motion trajectory does not intersect with the second motion trajectory.

[0106] The structures of the first reagent dispensing component 60 and the second reagent dispensing component 60 can be the same, but they are set in different directions. The first reagent dispensing component 60 is set in the direction of the reaction component 51 for cooperating with the reaction component 51, and the second reagent dispensing component 60 is set in the direction of the measuring component 52 for cooperating with the measuring component 52.

[0107] The above is some description of the reagent dispensing component 60. The reagent dispensing component 60 uses a beam structure to enable the reagent needle 61 to continuously perform reciprocating linear motion between the reagent aspiration position of the reagent carrying component 40 and the reagent addition position of the corresponding processing unit to complete the absorption and discharge of the corresponding reagent.

[0108] The movements of different reagent dispensing components 60 are independent and do not interfere with each other, thus playing a significant role in miniaturizing the space of the instrument and improving the test speed.

[0109] The scheduling component 70 is used to schedule cuvettes. For example, the scheduling component 70 schedules cuvettes that have completed sample loading and are located in the sample loading position to the various processing units 50 according to the detection process. For example, the scheduling component 70 schedules cuvettes that have completed the loading of reagents, such as the first reagent, at the incubation transfer position 51a to the reaction component 51, and schedules cuvettes that have completed the loading of reagents, such as the second reagent, at the measurement transfer position 52a to the measurement component 52. The specific structure of the scheduling component 70 is described below.

[0110] Please refer to Figure 11In some embodiments, the scheduling component 70 includes a first transport component 71, a second transport component 73, and a third transport component 75. To coordinate with these three transport components 71, 73, and 75, in some embodiments, the sample analyzer further includes a first cache transfer position 77 and a second cache transfer position 78. In some embodiments, the first cache transfer position 77 can adopt a fixed cache position design, having only one cuvette placement position, i.e., only one cuvette can be placed, which helps reduce the volume and size of the sample analyzer. Similarly, the first cache transfer position 78 can adopt a fixed cache position design, having only one cuvette placement position, i.e., only one cuvette can be placed, which helps reduce the volume and size of the sample analyzer. Of course, in some embodiments, the first cache transfer position 77 and the second cache transfer position 78, while adopting a fixed cache position design, can also be designed to have multiple cuvette placement positions, thereby allowing for more cuvette placement positions during scheduling. Even in some embodiments, the first cache transfer position 77 can be designed as a movable or rotating cache position. For example, the first cache transfer position 77 can include a cuvette placement position that can be driven to move or rotate. In this way, during the process of the first transfer component 71 transferring the cuvette to the first cache transfer position 77, the first cache transfer position 77 can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred by the first transfer component 71. In addition, when the second transfer component 73 needs to transfer the cuvette on the first cache transfer position 77, the first cache transfer position 77 can also be controlled to move or rotate to a predetermined position to enable the second transfer component 73 to grab the cuvette on the first cache transfer position 77 more quickly. Similarly, in the second cache The transfer position 78 may include a reaction cup placement position that can be driven to move or rotate, so that in the process of the second transfer component 73 transferring the reaction cup to the second cache transfer position 78, the second cache transfer position 78 can also be controlled to move or rotate to a predetermined position to receive the reaction cup transferred by the second transfer component 73. In addition, when the third transfer component 73 needs to transfer the reaction cup on the second cache transfer position 78, the second cache transfer position 78 can also be controlled to move or rotate to a predetermined position to enable the third transfer component 75 to grab the reaction cup on the second cache transfer position 78 more quickly; through such a design, the entire transfer process of the reaction cup can be made faster and less time-consuming, thereby improving the efficiency and testing speed of the sample analysis device.

[0111] There are many specific implementation methods of the first transfer component 71, the second transfer component 73 and the third transfer component 75. For example, a guide rail-type transfer component transfers the reaction cup by placing the reaction cup on the guide rail; another example is a turntable-type transfer component, which places the reaction cup on a turntable-type structure and transfers the reaction cup carried by the turntable to the corresponding position through the transfer of the turntable itself; for example, a two-dimensional or three-dimensional driving mechanism is used to drive a cup grabbing hand to implement the first transfer component 71, the second transfer component 73 and the third transfer component 75, the cup grabbing hand grabs the reaction cup, and then the two-dimensional or three-dimensional driving mechanism drives the cup grabbing hand to move, thereby realizing the transfer of the reaction cup to the corresponding position. The following is an explanation of the method of implementing the transfer component by using a cup grabbing hand.

[0112] 12( a ), the first transport component 71 , the second transport component 73 , and the third transport component 75 all include a cup gripper 79 and a driving component for driving the cup gripper 79 . In some embodiments, the cup gripper 79 is used to grip a reaction cup, for example Figure 13 This is a schematic diagram of the structure of the cup gripper 79. The opening and closing of the cup gripper 79 can be achieved by a drive mechanism and a spring. The cup gripper 79 can be opened by its drive mechanism. When the drive mechanism is not driven, the cup gripper 79 automatically closes and clamps the clamped object, such as a reaction cup, via its spring. In some examples, the reaction cup can be provided with a circle of protrusions adapted to the gripper's grip.

[0113] The following describes each transfer component and its function.

[0114] The first transport component 71 is used to transport the loaded cuvette to the first buffer transfer position 77. In some embodiments, the first transport component 71 moves linearly along a first direction, such as the Y direction in the figure, to transport the loaded cuvette to the first buffer transfer position 77. Because the first transport component 71 moves the cuvette linearly, the volume of the sample analyzer occupied during cuvette transport is relatively reduced, facilitating a miniaturized design of the sample analyzer.

[0115] Please refer to Figure 14In some embodiments, the sample analysis device may further include a sample loading station 10a, a pre-dilution station 10b, a first cup ejection station 10c, and a second cup ejection station 10d. In some embodiments, the first transport component 71 may move along a first direction, such as the Y direction in the figure, between the sample loading station 10a, the pre-dilution station 10b, the first cup ejection station 10c, and the first buffer transfer station 77. The sample loading station 10a may be the predetermined location where the cuvette loading unit 10 mentioned above loads an empty cuvette. Generally, the sample dispensing unit 30 draws sample from the sample aspiration station and discharges it into the cuvette located at the sample loading station 10a to complete the sample loading. In some cases, the sample needs to be pre-diluted. Therefore, in this case, the first transport component 71 first transports the empty reaction cup on the sample loading position 10a to the pre-dilution position 10b, and the sample dispensing component 30 draws the sample from the sample aspiration position and discharges it into the reaction cup at the pre-dilution position 10b, and then dilutes the sample in the reaction cup at the pre-dilution position 10b; in this process, the reaction cup loading component 10 loads a new empty reaction cup onto the sample loading position 10a, and then the sample dispensing component 30 draws the pre-diluted sample from the reaction cup on the pre-dilution position 10b and discharges it into the sample loading position 10a, thereby completing the sample loading; the first transport component 71 then performs cup throwing processing on the reaction cup on the pre-dilution position 10b, for example, transports it to the first cup throwing position 10c for cup throwing.

[0116] As described above, in some embodiments, the first transfer component 71 only needs to move along the first direction, so the driving component of the first transfer component 71 can be a two-dimensional driving component, used to drive the cup grabbing hand 79 of the first transfer component 71 to move along the first direction and the vertical direction, wherein the first direction can be the Y direction in the figure, and the vertical direction is the direction perpendicular to the paper in the figure. Please refer to Figure 12(b). In some embodiments, the first transfer component 71 includes a first direction guide 71a, a first direction driving component 71b, a vertical direction guide 71c and a vertical direction driving component 71d; the cup grabbing hand 79 of the first transfer component 71 is slidably provided on the vertical direction guide 71c, and the cup grabbing hand 79 can move in the vertical direction along the vertical direction guide 71c by driving the vertical direction guide 71c; the vertical direction guide 71c is slidably provided on the first direction guide 71a, and the vertical direction driving component 71b can move along the first direction guide 71a in the first direction, thereby driving the cup grabbing hand 79 of the first transfer component 71 to move in the first direction. Through such a structure, the cup grabbing hand 79 of the first transfer component 71 can be moved in two dimensions, namely, the first direction and the vertical direction. In some specific embodiments, the first direction guide 71a may include a first guide rail; the first direction drive component 71b may include a first stepper motor, a first driven pulley, and a first synchronous belt, the first synchronous belt being sleeved between the first stepper motor and the first driven pulley, and the vertical direction guide 71c may be fixedly connected to the first synchronous belt; similarly, the vertical direction guide 71c may include a vertical guide rail; the vertical direction drive component 71d may include a lifting stepper motor and a vertical screw, and a mounting plate may be threadedly mounted on the vertical screw for mounting the cup gripper 79 of the first transfer component 71. In some embodiments, the first transfer component 71 may further include a first bracket 71f for mounting the first direction guide 71a.

[0117] In some embodiments, the cup grabbing hand 79 of the first transport component 71 grabs the reaction cup on the sample loading position 10a, for example, along the second direction, for example, the X direction in the figure. In this way, the first transport component 71 will not affect the sample dispensing component 30 from discharging the sample into the reaction cup when grabbing the reaction cup. As a result, the first transport component 71 can grab the reaction cup while the sample dispensing component 30 completes the loading of the sample into the reaction cup, saving time and improving measurement speed and efficiency.

[0118] The above is some description of the first transfer component 71.

[0119] The second transport component 73 is used to transport cuvettes from the first buffer transfer position 77 to the reaction component 51, and to transport cuvettes in the reaction component 51 after sample incubation has completed to the second buffer transfer position 78. In some embodiments, the second transport component 73 transports the cuvettes from the first buffer transfer position 77 to the reaction component 51, and to transport cuvettes in the reaction component 51 after sample incubation has completed to the second buffer transfer position 78, by linear motion along a first direction, such as the X direction in the figure, and a second direction, such as the X direction in the figure. Because the second transport component 73 moves the cuvettes in a linear motion, the volume of the sample analysis device occupied during cuvette transport is relatively reduced, facilitating a miniaturized design of the sample analysis device.

[0120] During the specific transfer process, the second transfer component 73 can first transport the reaction cup of the first cache transfer position 77 to the incubation transfer position 51a, the reagent dispensing component 60 absorbs the reagent and discharges it into the reaction cup located at the incubation transfer position 51a, and the second transfer component 73 then transports the reaction cup of the incubation transfer position 51a to the reaction component 51.

[0121] In some embodiments, the second transfer component 73 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., a direction perpendicular to the drawing), so the driving component of the second transfer component 73 can be a three-dimensional driving component, used to drive the cup grabbing hand 79 of the second transfer component 73 to move along the first direction, the second direction, and the vertical direction. 12( c ), in some embodiments, the second transfer component 73 includes a first direction guide 73a, a first direction driving component 73b, a second direction guide 73c, a second direction driving component 73d, a vertical direction guide 73e, and a vertical direction driving component 73f; a cup grabbing hand 79 of the second transfer component 73 is slidably provided on the vertical direction guide 73e, and driven by the vertical direction guide 73f, so that the cup grabbing hand 79 can move in the vertical direction along the vertical direction guide 73e; a vertical direction guide 73e is slidably provided on the second direction guide 73c, and driven by the second direction driving component 73d, so that the vertical direction guide 73e can move in the second direction along the second direction guide 73c, thereby driving The cup grabbing hand 79 of the second transfer component 73 also moves in the second direction; a second direction guide 73c is slidably provided on the first direction guide 73a, and driven by the first direction driving component 73b, the second direction guide 73c can move in the first direction along the first direction guide 73a, thereby driving the second direction guide 73c to move in the first direction, thereby driving the vertical direction guide 73e on the second direction guide 73c to move in the first direction, thereby driving the cup grabbing hand 79 of the second transfer component 73 on the vertical direction guide 73e to move in the first direction; through such a structure, the cup grabbing hand 79 of the second transfer component 73 can be moved in three directions: the first direction, the second direction and the vertical direction. In some specific embodiments, the first directional guide 73a may include a first guide rail; the first directional drive component 73b may include a first stepper motor, a first driven wheel, and a first synchronous belt, the first synchronous belt being sleeved between the first stepper motor and the first driven wheel, and the second directional guide 73c may be fixedly connected to the first synchronous belt; similarly, the second directional guide 73c may include a second guide rail; the second directional drive component 73d may include a second stepper motor, a second driven wheel, and a second synchronous belt, the second synchronous belt being sleeved between the second stepper motor and the second driven wheel, and the vertical directional guide 73e may be fixedly connected to the second synchronous belt; similarly, the vertical directional guide 73e may include a vertical guide rail; the vertical directional drive component 73f may include a lifting stepper motor and a vertical screw, the vertical screw being threaded with a mounting plate for mounting the cup gripper 79 of the second transfer component 73. In some embodiments, the second transfer component 73 may further include a second bracket 73g for mounting the first directional guide 73a.

[0122] In some embodiments, the cup gripper 79 of the second transport component 73 grasps the cuvette along a second direction, such as the X direction in the figure. This allows the second transport component 71 to grasp the cuvette without interfering with the reagent dispensing component 60, such as the first reagent dispensing component, adding reagent to the cuvette. This allows the second transport component 73 to grasp the cuvette while the reagent dispensing component 60 completes the addition of reagent to the cuvette, saving time and improving measurement speed and efficiency. In some embodiments, the direction in which the second transport component 73 grasps the cuvette is greater than 90 degrees from the direction of linear motion of the first set of reagent needles. In this way, the action of the second transport component 73 grasping the cuvette and the action of the first set of reagent needles adding reagent are less likely to conflict, and the two can reasonably perform their corresponding actions independently and in parallel.

[0123] In some embodiments, the second transport component 73 also mixes the sample in the cuvette while transporting it from the incubation transfer station 51a to the reaction unit 51. For example, after the second transport component 73 transfers the sample-loaded cuvette from the first buffer transfer station 77 and places it in the incubation transfer station 51a, the reagent dispensing component 60 then adds a reagent, such as the first reagent, to the cuvette in the incubation transfer station 51a. The second transport component 73 then picks up the reagent-loaded cuvette, mixes it, and then transports it to the reaction unit 51. Specifically, the second transport component 73 can rapidly shake the cup gripper 79 via the drive component 71b to mix the sample in the cuvette grasped by the cup gripper 79. The second transport component 73's mixing function eliminates the need for a separate mixing mechanism in the sample analyzer, making the sample analyzer more compact and reducing costs. Furthermore, the second transport component 73 performs mixing when grabbing the cuvette for transport, saving time by eliminating the need to specifically dispatch the cuvette to the mixing mechanism for mixing.

[0124] The above is some description of the second transport component 73. The second transport component 73 can and realizes the transfer of reaction cups between the first buffer transfer position 77, the incubation transfer position 51a, the reaction component 51 and the second buffer transfer position 78 by linear motion along the first direction and the second direction.

[0125] The third transport component 75 is used to transport the cuvettes in the second buffer transfer position 78 to the measurement component 52. In some embodiments, the third transport component 75 transports the cuvettes in the second buffer transfer position 78 to the measurement component 52 by linear motion along a first direction, such as the X direction in the figure, and a second direction, such as the X direction in the figure. Because the third transport component 75 moves the cuvettes linearly, the volume of the sample analyzer occupied during cuvette transport is relatively reduced, facilitating a miniaturized design of the sample analyzer.

[0126] During the specific transport process, the third transport component 75 may first transport the cuvette from the second buffer transfer position 78 to the measurement transfer position 52a. The reagent dispensing component 60 then aspirates the reagent and discharges it into the cuvette located in the measurement transfer position 52a. The third transport component 75 then transports the cuvette from the measurement transfer position 75a to the measurement component 52. In some embodiments, when the third transport component 75 transports the cuvette from the second buffer transfer position 78 to the measurement transfer position 52a, the third transport component 75 may not place the cuvette in the measurement transfer position 52a, but may still hold the cuvette. In this case, the reagent dispensing component 60 aspirates the reagent and discharges it into the cuvette. This reduces the time it takes for the cuvette to finally enter the measurement component 52 from the second buffer transfer position 78, thereby improving test speed.

[0127] In some embodiments, the third transfer component 75 can move along the first direction (e.g., the Y direction in the figure), the second direction (e.g., the X direction in the figure), and the vertical direction (e.g., the direction perpendicular to the drawing), so the driving component of the third transfer component 75 can be a three-dimensional driving component, used to drive the cup grabbing hand 79 of the third transfer component 75 to move along the first direction, the second direction, and the vertical direction. 12( d ), in some embodiments, the third transfer component 75 includes a first direction guide 75a, a first direction driving component 75b, a second direction guide 75c, a second direction driving component 75d, a vertical direction guide 75e, and a vertical direction driving component 75f; a cup grabbing hand 79 of the third transfer component 75 is slidably provided on the vertical direction guide 75e, and driven by the vertical direction guide 75f, the cup grabbing hand 79 can move in the vertical direction along the vertical direction guide 75e; a vertical direction guide 75e is slidably provided on the second direction guide 75c, and driven by the second direction driving component 75d, the vertical direction guide 75e can move in the second direction along the second direction guide 75c, thereby driving The cup grabbing hand 79 of the third transfer component 75 also moves in the second direction; a second direction guide 75c is slidably provided on the first direction guide 75a, and driven by the first direction driving component 75b, the second direction guide 75c can move in the first direction along the first direction guide 75a, thereby driving the second direction guide 75c to move in the first direction, thereby driving the vertical direction guide 75e on the second direction guide 75c to move in the first direction, thereby driving the cup grabbing hand 79 of the third transfer component 75 on the vertical direction guide 75e to move in the first direction; through such a structure, the cup grabbing hand 79 of the third transfer component 75 can be moved in three directions: the first direction, the second direction and the vertical direction. In some specific embodiments, the first directional guide 75a may include a first guide rail; the first directional drive component 75b may include a first stepper motor, a first driven wheel, and a first synchronous belt, the first synchronous belt being sleeved between the first stepper motor and the first driven wheel, and the second directional guide 75c may be fixedly connected to the first synchronous belt; similarly, the second directional guide 75c may include a second guide rail; the second directional drive component 75d may include a second stepper motor, a second driven wheel, and a second synchronous belt, the second synchronous belt being sleeved between the second stepper motor and the second driven wheel, and the vertical guide 75e may be fixedly connected to the second synchronous belt; similarly, the vertical guide 75e may include a vertical guide rail; the vertical drive component 75f may include a lifting stepper motor and a vertical screw, the vertical screw being threaded with a mounting plate for mounting the cup gripper 79 of the third transport component 75. In some embodiments, the third transport component 75 may further include a second bracket 75g for mounting the first directional guide 75a.

[0128] In some embodiments, the cup gripper 79 of the third transport component 75 grasps the cuvette along a first direction, such as the Y direction in the figure. This allows the third transport component 75 to grasp the cuvette while it is grasping the cuvette—even if the third transport component 75 is grasping the cuvette throughout the reagent addition process—without interfering with the reagent dispensing component 60, such as the second reagent dispensing component, from adding reagent to the cuvette. This allows the reagent dispensing component 60 to complete the addition of reagent to the cuvette while the third transport component 75 is grasping the cuvette, saving time and improving measurement speed and efficiency. In some embodiments, the direction in which the third transport component 75 grasps the cuvette is greater than 90 degrees from the direction of linear motion of the second set of reagent needles. This reduces the likelihood of conflict between the third transport component 75 grasping the cuvette and the second set of reagent needles adding reagent, allowing the two to perform their respective actions independently and in parallel.

[0129] In some embodiments, the third transport component 75 mixes the sample in the cuvette during the process of transporting the cuvette from the measurement transfer position 52a to the measurement component 52. For example, when the third transport component 75 transports the cuvette from the second buffer transfer position 78 to the measurement transfer position 52a, in some embodiments, the third transport component 75 may not put down the cuvette when transporting the cuvette to the measurement transfer position 52a, but may still hold the cuvette; the reagent dispensing component 60 then adds a reagent, such as a second reagent, to the cuvette in the measurement transfer position 52a, and the third transport component 75 then mixes the sample in the held cuvette before transporting it to the measurement component 52. Specifically, the third transport component 75 can achieve mixing of the sample in the cuvette held by the cup gripper 79 by rapidly shaking the cup gripper 79 via the driving component 71b. The third transport component 75 also has a mixing function, so that the sample analysis device no longer needs to be equipped with an independent mixing mechanism, making the sample analysis device more compact and reducing costs. In addition, the third transport component 75 mixes the reaction cup along the original transport path, such as at the transfer position 52a during measurement, which saves time and eliminates the need to specifically dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0130] In some examples, after dispatching the reaction cup to the measuring component 52, the third transport component 75 can also grab the reaction cup that has been measured in the measuring component 52, and then transport it to the second cup throwing position 10d for cup throwing processing. In some embodiments, the second cup throwing position 10d can be set near the second cache transfer position 78, or between the measuring component 52 and the second cache transfer position 78. In this way, when the third transport component 75 transfers the reaction cup on the second cache transfer position 78 from the measuring component 52 to the second cache transfer position 78 to transfer the reaction cup on the second cache transfer position 78, it can also perform cup throwing processing on the reaction cup that has been measured on the measuring component 52, thereby saving time and improving test efficiency.

[0131] The above is a brief description of the third transport component 75. The third transport component 75 can transport cuvettes between the second buffer transfer position 78, the measurement transfer position 52a, the measurement component 52, and even the second cup throwing position 10d by linear motion along the first and second directions.

[0132] The above is an explanation of the scheduling component 70 of some embodiments of the present invention. The present application uses three transfer components, namely the first transfer component 71, the second transfer component 73 and the third transfer component 75, to complete the rapid transfer of the reaction cup. The scheduling path of the reaction cup is simple and direct, which is conducive to speeding up the sample analysis device; and then cooperates with two cache transfer positions, namely the first cache transfer position 77 and the second cache transfer position 78 to complete the transition between the three transfer components, which is also simple and compact in structure.

[0133] The above is the sample analysis device disclosed in some embodiments of the present invention. It is understandable that the sample analysis device disclosed in the present invention may also include some other structures, such as a cleaning component 80 and / or a processor 90, etc. Figure 15 and Figure 16 Let’s explain it in detail.

[0134] The cleaning component 80 is used to clean the reagent needle, such as the first reagent needle and the second reagent needle. Specifically, the cleaning component 80 may include a plurality of cleaning pools 81, and the number of cleaning pools 81 may be the same as the number of reagent needles. For example, when the sample analysis device includes a first reagent dispensing component and a second reagent dispensing component, and each reagent dispensing component includes two reagent needles, the number of cleaning pools may be four. A cleaning pool may be provided on the linear motion trajectory of each reagent needle for cleaning the reagent needle. Please refer to Figure 16, cleaning component 80 is used for cleaning reagent needle, specifically, can be to carry out the cleaning of inner wall and outer wall of reagent needle by cleaning fluid.Cleaning component 80 comprises the cleaning tank in the figure, pipeline and the switch valve etc. that are arranged on pipeline.The end of reagent needle can be connected to a pipeline, and this pipeline opens and closes by switch valve SV01. When switch valve SV01 is opened, cleaning fluid can reach the end of reagent needle by pipeline, flow through the inner wall of reagent needle, and flow out from the front end of reagent needle, and complete cleaning fluid and the inner wall cleaning of reagent needle.Cleaning chamber is also connected to a pipeline, and this pipeline opens and closes by switch valve SV02. When switch valve SV02 is opened, cleaning fluid can reach the cleaning chamber by pipeline, and spray to the outer wall of reagent needle from the inner wall of cleaning chamber, and complete cleaning fluid and the outer wall cleaning of reagent needle.The lower end of cleaning chamber is connected to a waste liquid suction valve SV03 by pipeline. When waste liquid suction valve SV03 is opened, the waste liquid after cleaning flows out through the lower end of cleaning chamber. During cleaning, the reagent needle reaches the top of the cleaning chamber and then moves downward, extending the portion of the reagent needle (at least the portion of the needle that contacts the reagent liquid surface during reagent aspiration) into the cleaning chamber so that the cleaning fluid sprayed from the cleaning chamber can clean the portion of the needle that contacts the liquid surface, completing the cleaning of the reagent needle. Each cleaning tank 81 can share a common fluid circuit to provide cleaning fluid for cleaning the reagent needle.

[0135] Some specific work processes of the sample analysis device are described below.

[0136] The sample analysis device in some embodiments may operate in the following manner.

[0137] The cuvette loading unit 10 supplies and carries empty cuvettes. For example, the cuvette loading unit 10 can load empty cuvettes into a predetermined position, which can be used as a sample loading station. The sample unit 20, such as the sample injection unit 21, dispatches a sample rack carrying samples to the sample aspiration station. The sample dispensing unit 30 draws samples from the sample aspiration station and dispenses them into a cuvette. For example, the sample dispensing unit draws samples from the sample aspiration station and then dispenses them into a cuvette located at the sample loading station, completing the sample loading.

[0138] The driving component of the reagent carrying component 60 drives the reagent carrying component 60 to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position. At least one of the two reagent needles 61 on the first reagent dispensing component 60 absorbs the first reagent in the reagent container through the first reagent suction position, and makes a linear motion between the first reagent suction position and the reagent adding transfer position of the reaction component 51 to dispense the first reagent into the reaction cup at the reagent adding transfer position of the reaction component 51. The reagent adding transfer position of the reaction component 51 can be the incubation transfer position 51a mentioned herein. In some embodiments, the two first reagent needles 61 of the first reagent dispensing component 60 make a linear motion independently of each other between the first reagent suction position and the reagent adding transfer position of the reaction component 51. In this way, the two first reagent needles 61 of the first reagent dispensing component 60 can separately and independently - for example, alternately - complete the operation of adding the first reagent to the reaction cup on the reagent adding transfer position of the reaction component 51, thereby improving the test speed and efficiency. In some specific embodiments, each first reagent needle 61 in the first reagent dispensing component 60 sequentially performs multiple preset actions to complete the first reagent addition operation, and at least one corresponding preset action between two first reagent needles 61 does not overlap in timing. In this way, the two reagent needles 61 in the first reagent dispensing component 60 can minimize the occupation of common resources, thereby reducing the number of components providing corresponding common resources, thereby making the sample analyzer more compact. Moreover, this arrangement of the action timing of the two first reagent needles 61 also minimizes mutual interference between them, which is very beneficial for speeding up the sample analyzer.

[0139] The dispatching unit 70 dispatches the cuvette after the first reagent is dispensed to the reaction unit 51 for incubation, and dispatches the cuvette after the incubation to the reagent transfer position of the measurement unit 52. The reagent transfer position of the measurement unit 52 can be the measurement transfer position 52a mentioned herein.

[0140] The reagent carrying component 40 rotates so that the reagent container carrying the second reagent is located at the second reagent suction position. At least one of the two reagent needles on the second reagent dispensing component 60 absorbs the second reagent in the reagent container through the second reagent suction position and makes a linear motion between the second reagent suction position and the reagent adding transfer position of the measuring component to dispense the second reagent into the reaction cup at the reagent adding transfer position of the measuring component 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing component 60 move linearly between the second reagent suction position and the reagent adding transfer position of the measuring component 52 independently of each other. In this way, the two second reagent needles 61 of the second reagent dispensing component 60 can separately and independently - for example, alternately complete the operation of adding the second reagent to the reaction cup at the reagent adding transfer position of the measuring component 52, thereby improving the test speed and efficiency. In some specific embodiments, each second reagent needle 61 in the second reagent dispensing component 60 performs multiple preset actions in sequence to complete the second reagent adding operation, and among the multiple preset actions between the two second reagent needles 61, at least one corresponding preset action does not overlap in time sequence. In this way, the two reagent needles 61 of the second reagent dispensing component 60 can avoid occupying public resources as little as possible, so that the number of components providing corresponding public resources can be reduced, and the sample analysis device can be more compact; and arranging the action timing of the two second reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial for speeding up the sample analysis device.

[0141] The scheduling component 70 schedules the reaction cup after the second reagent is dispensed to the measurement component 52 for item testing, and schedules the reaction cup after the test to a waste recovery device, such as the second cup disposal position mentioned herein.

[0142] Some embodiments of the present invention also disclose a sample analysis method. Figure 17 In some embodiments, the sample analysis method includes the following steps:

[0143] Step 100, i.e., the cuvette loading step, controls the cuvette loading component to supply and carry an empty cuvette. For example, the cuvette loading component can load the empty cuvette into a predetermined position, which can be used as a sample loading position.

[0144] Step 110, ie, the sample feeding step, controls the sample component, such as the sample feeding component, to dispatch the sample rack carrying the sample to the sample aspiration position.

[0145] Step 120, i.e., the sample dispensing step, controls the sample dispensing component to draw the sample from the sample aspirating position and dispense it into the reaction cup. For example, the sample dispensing component draws the sample from the sample aspirating position and then discharges it into the reaction cup located on the sample loading position to complete the sample loading.

[0146] Through the above steps 100 to 120, the sample addition is completed.

[0147] Step 130, i.e., the first reagent dispensing step, involves controlling the driving component of the reagent carrying component to rotate the reagent carrying component so that the reagent container carrying the first reagent is positioned at the first reagent aspiration position. At least one of the two reagent needles on the first reagent dispensing component is controlled to aspirate the first reagent from the reagent container through the first reagent aspiration position and to move linearly between the first reagent aspiration position and the reagent addition intermediate transfer position of the reaction component to dispense the first reagent into the reaction cup at the reagent addition intermediate transfer position of the reaction component. The reagent addition intermediate transfer position of the reaction component in step 130 may be the incubation intermediate transfer position mentioned herein.

[0148] In some embodiments, step 130 controls the two first reagent needles of the first reagent dispensing component to independently move linearly between the first reagent suction position and the reagent adding transfer position of the reaction component. In this way, the two first reagent needles of the first reagent dispensing component can independently and separately, for example, alternately complete the operation of adding the first reagent to the reaction cup on the reagent adding transfer position of the reaction component, thereby improving the test speed and efficiency. In some specific embodiments, step 130 controls each first reagent needle in the first reagent dispensing component to perform multiple preset actions in sequence to complete the first reagent adding operation, and among the multiple preset actions between the two first reagent needles, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles of the first reagent dispensing component can avoid occupying public resources as little as possible, so that the number of components providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and arranging the action timing of the two first reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial for speeding up the sample analysis device. It should be noted that the multiple preset actions vary depending on different testing requirements. In one embodiment, the multiple preset actions include the following four: reagent aspiration, heating, reagent discharge, and cleaning. Between each pair of first reagent needles, at least one of the four actions does not overlap in timing.

[0149] Step 130 completes the process of adding the first reagent into the reaction cup containing the sample.

[0150] Step 140, the incubation step, controls the dispatching component to dispatch the cuvette that has completed first reagent dispensing to the reaction component for incubation. After incubation, the cuvette is dispatched to the reagent transfer station in the assay component. In step 140, the reagent transfer station in the assay component can be the assay transfer station mentioned herein.

[0151] Step 150, i.e., the second reagent dispensing step, controls the reagent carrying component to rotate so that the reagent container carrying the second reagent is located at the second reagent aspirating position; controls at least one of the two reagent needles on the second reagent dispensing component to absorb the second reagent in the reagent container through the second reagent aspirating position, and to make a linear motion between the second reagent aspirating position and the reagent adding transfer position of the measuring component, so as to dispense the second reagent into the reaction cup at the reagent adding transfer position of the measuring component.

[0152] In some embodiments, step 150 controls the two second reagent needles of the second reagent dispensing component to independently move linearly between the second reagent aspiration position and the reagent adding transfer position of the measuring component. In this way, the two second reagent needles of the second reagent dispensing component can independently and separately, for example, alternately complete the operation of adding the second reagent to the reaction cup on the reagent adding transfer position of the measuring component, thereby improving the test speed and efficiency. In some specific embodiments, step 150 controls each second reagent needle in the second reagent dispensing component to perform multiple preset actions in sequence to complete the second reagent adding operation, and among the multiple preset actions between the two second reagent needles, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles of the second reagent dispensing component can avoid occupying public resources as much as possible, so that the number of components providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and arranging the action timing of the two second reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial for speeding up the sample analysis device. It should be noted that the multiple preset actions vary depending on different testing requirements. In one embodiment, the multiple preset actions include the following four: reagent aspiration, heating, reagent discharge, and cleaning. Between each second reagent needle, at least one of the four actions does not overlap in timing.

[0153] Step 150 completes the process of adding the second reagent into the reaction cup carrying the incubated reagent.

[0154] Step 160, i.e., the measurement and recovery step, controls the scheduling component to schedule the reaction cup after the second reagent is dispensed to the measurement component for project testing, and schedules the reaction cup after the test to the waste recovery device - the waste recovery device can have, for example, the second cup throwing position mentioned in this article.

[0155] The above is an overall working process of the sample analysis device.

[0156] The workflow arrangement of the reagent dispensing component 60 imposes an important constraint on the speed of completing the test. Each reagent needle needs to complete actions such as sample aspiration, heating, sample discharge and cleaning. The reagent carrying component 40 is used to ensure the activity of the reagent, and the temperature is generally low, for example, below 16°C. After the reagent is taken out of the reagent carrying component 40, it needs to be heated to about 37°C in the reagent needle within a short period of time to ensure that the reaction process is sufficient. Under normal circumstances, the heating time of the reagent needle's heating component for the reagent absorbed by the reagent needle is 4 to 10 seconds. During the detection process of different test items, the reagent needle needs to absorb different types of reagents. For example, in the detection of the four routine coagulation items (PT / APTT / TT / FIB), different second reagents, i.e., trigger reagents, need to be drawn from the reagent carrying component 40 in turn and added to the reaction cup for reaction. Therefore, the same reagent needle needs to be cleaned normally or strongly when absorbing reagents for different items. In order to ensure the cleaning effect and avoid the carryover contamination between reagents affecting the accuracy of the test results, the cleaning time generally takes 2 to 8 seconds. The sample aspiration and sample discharge actions generally take 1.5 to 3 seconds (including the horizontal movement time). Therefore, for a sample analysis device with a single working cycle of, for example, 8 seconds, it is difficult to complete all the above-mentioned operations such as sample aspiration, heating, sample discharge and cleaning within one working cycle, and the overall detection speed is nearly reduced.

[0157] In some embodiments of the present invention, how the sample analysis device performs the reagent adding operation, that is, how to arrange the action sequence of each reagent needle, is designed, which is described in detail below.

[0158] In some embodiments, the processor 90 is configured to control each reagent needle within the same group to sequentially perform multiple preset actions—such as a reagent aspiration action, a reagent needle heating action, a reagent discharge action, and a reagent needle cleaning action—to complete the reagent addition operation, and at least one corresponding preset action between two reagent needles within the same group does not overlap in timing. For example, if the first group of reagent needles in the first reagent dispensing component 60 includes two first reagent needles, at least one corresponding preset action between the two first reagent needles does not overlap in timing. For another example, if the second group of reagent needles in the second reagent dispensing component 60 includes two second reagent needles, at least one corresponding preset action between the two second reagent needles does not overlap in timing. In some embodiments, a ping-pong mode can be set for the sample analysis device. When this mode is enabled, the processor 90 executes the ping-pong mode so that at least one corresponding action between two reagent needles in each group of reagent needles does not overlap in timing. For example, in the reagent aspirating action, reagent heating action, reagent discharge action, and reagent needle cleaning action of two reagent needles in the same group of reagent needles, at least one corresponding action does not overlap in timing; this at least one corresponding action includes a reagent aspirating action and / or a reagent needle cleaning action. In other embodiments, for all reagent needles (including the first reagent needle and the second reagent needle) that perform reagent dispensing in the sample analysis device, the processor will control each reagent to perform multiple preset actions in sequence to complete the reagent addition operation, and at least one corresponding preset action among the multiple preset actions between two reagent needles does not overlap in timing. For example, the first reagent needle includes the first reagent needle a1 and the first reagent needle a2, and the second reagent needle includes the second reagent needle b1 and the second reagent needle b2. When the processor controls the first reagent needle a1, first reagent needle a2, second reagent needle b1, and second reagent needle b2 to each complete multiple preset actions, at least one corresponding preset action does not overlap in timing. By scheduling all the reagent needles in the sample analyzer, the processor prevents the actions of the reagent needles from interfering with each other and occupying resources, thereby more effectively utilizing shared resources and improving the sample testing efficiency of the sample analyzer.

[0159] In some embodiments of the present invention, the above-mentioned multiple preset actions may include a first type of preset actions and a second type of preset actions. The first type of preset actions are actions in which each reagent needle needs to interact with the same component. Usually, the first type of preset actions may be some actions in which the reagent needle needs to occupy common resources, such as the reagent suction action - this requires occupying the common component of the reagent carrying component 40, such as the reagent needle cleaning action - this requires occupying the pipeline that provides cleaning liquid for each cleaning pool 81; therefore, the first type of preset actions at least include the reagent suction action and the reagent needle cleaning action. The second type of preset actions are actions in which each reagent does not need to interact with the same component. Usually, the second type of preset actions may be some actions in which the reagent needle does not need to occupy common resources, such as the reagent heating action - each reagent needle heats the absorbed reagent through its own heating component; therefore, the second type of preset actions at least include the reagent heating action in the reagent needle. In some embodiments, the first type of preset actions corresponding to each pair of reagent needles in the same group do not overlap in timing, for example, the reagent suction action between each pair of reagent needles in the same group does not overlap in timing, and the reagent needle cleaning action does not overlap in timing, for example Figure 18 is an example.

[0160] In some embodiments, each corresponding preset action in the plurality of preset actions between two reagent needles in the same group does not overlap in time sequence. Figure 19 For example, the first group of reagent needles in the first reagent dispensing component 60 includes two first reagent needles. The reagent aspiration actions of these two first reagent needles do not overlap in timing, the reagent heating actions in the reagent needles do not overlap in timing, the reagent discharge actions do not overlap in timing, and the reagent needle cleaning and reagent aspiration actions do not overlap in timing. For another example, the second group of reagent needles in the second reagent dispensing component 60 includes two second reagent needles. The reagent aspiration actions of these two second reagent needles do not overlap in timing, the reagent heating actions in the reagent needles do not overlap in timing, the reagent discharge actions do not overlap in timing, and the reagent needle cleaning and reagent aspiration actions do not overlap in timing.

[0161] In some embodiments, the time interval between the output results of two adjacent and identical test items when the sample analysis device completes a fixed test volume is defined as a cycle, and the number of reagent needles set for each reagent dispensing component is equal to the number of cycles occupied by a reagent needle to complete the multiple preset actions. For example, the number of cycles occupied by a reagent needle to complete the above-mentioned multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) is two, then two reagent needles are set for the reagent dispensing component, or the number of reagent needles in the same group is two. From another perspective, in some embodiments, the processor 90 controls each reagent needle of the reagent dispensing component to complete the multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) within a preset time, and the preset time is equal to N times the cycle, and N is equal to the number of reagent needles of the reagent dispensing component. For example, the number of reagent needles of each reagent dispensing component 60 is two, then N is equal to two, and each reagent needle needs to complete the multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) within two cycles. By setting the number of reagent needles of the reagent dispensing component and the cycle for completing the multiple preset actions in this way, the sample analysis device can eventually be made equivalent in terms of test speed to each reagent needle completing the multiple preset actions (such as reagent aspiration action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) within one cycle, ensuring that the speed at which the sample analysis device outputs the test results is constant. Here, a preset time is mentioned. In some embodiments, when the time taken by the reagent needle to perform multiple preset actions is less than the preset time, in order to further ensure that the speed at which the sample analysis device outputs the test results is constant, the reagent needle will wait so that the waiting time plus the time taken to complete the multiple preset actions is equal to the preset time. In order to be able to explain more clearly, the preset time includes action time and waiting time, wherein the action time is used to perform the above-mentioned preset actions (such as reagent aspiration action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action), and the action time is less than or equal to the preset time. In some embodiments, the waiting time is divided into one or more time periods and is inserted between the plurality of preset actions and / or after the last preset action in terms of timing—for example, it is inserted between the reagent aspirating action, the reagent heating action in the reagent needle, the reagent discharging action, and the reagent needle cleaning action and / or after the reagent needle cleaning action in terms of timing; for example Figure 20is an example. In some embodiments, the waiting time is divided into one or more time periods, and at least one period is used as additional action time in the timing sequence to execute the preset action. In this way, the preset action can have extra time to continue to execute. Under the constraint of the preset time, the execution time of the preset action is extended, which can make the reagent needle have a more stable performance. For example, the execution time of the reagent aspiration action and the reagent discharge action is extended, which can make the reagent needle more stable in aspirating and discharging reagents, and not easily cause abnormal situations such as empty aspiration or collision with the reaction cup. For another example, the execution time of the reagent heating action in the reagent needle is extended, which can make the reagent in the reagent be fully preheated; for another example, the execution time of the reagent needle cleaning action is extended, which can make the reagent needle be cleaned more fully, not easily cause cross contamination of the next test item, and improve the accuracy of the test results. Therefore, in some embodiments, the sample analysis device may include a full heating mode. When the full heating mode is enabled, the processor 90 executes the full heating mode so that the waiting time is divided into one or more time periods, and at least one of the time periods is used as an additional action time for performing the reagent heating action in the reagent needle. For example Figure 21 is an example.

[0162] It needs to be said that some Figures 18 to 21 In order to facilitate drawing, the heating action in the figure refers to the reagent heating action in the reagent needle in this article, and the cleaning action refers to the reagent needle cleaning action in this article; Figures 18 to 21 The two reagent needles drawn in the figure refer to two reagent needles in the same group, for example, two first reagent needles in the first group of reagent needles, or two second reagent needles in the second group of reagent needles.

[0163] The present invention designs the action sequence of the reagent needle, introduces a reagent dispensing component with, for example, two reagent needles arranged in parallel, and the dual reagent needles that run independently in a straight line are scheduled through ping-pong, and the entire workflow of reagent aspiration, preheating, reagent discharge and cleaning is completed in an extended cycle, providing double resources to ensure speed improvement, thereby achieving the goal of testing multiple detection items without slowing down.

[0164] Next, the cuvette is dispatched by the dispatching component 70. In some embodiments, the present invention transports the cuvette using three transport components and two buffer transfer positions.

[0165] Some embodiments of the present invention also disclose a method of a sample analysis device, please refer to Figure 22 , the method may include the following steps:

[0166] Step 200: Control the first transport component to transport the loaded cuvette to the first buffer transfer position. In some embodiments, step 200 controls the first transport component to move linearly in a first direction to transport the loaded cuvette to the first buffer transfer position.

[0167] In step 210, the second transport component is controlled to transport the cuvette transferred from the first buffer to the incubation position. The incubation position may be the cuvette placement position in the reaction component 51. In some embodiments, step 210 controls the second transport component to transport the cuvette transferred from the first buffer to the incubation position by linear motion in a first direction and a second direction.

[0168] Step 220: Control the second transport component to transport the cuvette in which the sample incubation is completed in the incubation position to the second buffer transfer position.

[0169] In some embodiments, step 220 controls the second transport component to transport the cuvette in the incubation position, where the sample has been incubated, to the second buffer transfer position via linear motion in the first direction and linear motion in the second direction. In some specific embodiments, step 220 controls the second transport component to first transport the cuvette in the first buffer transfer position to the incubation transfer position for reagent addition, and then transport the cuvette in the incubation transfer position, where the reagent has been added, to the incubation position.

[0170] In some specific embodiments, in step 220, the second transport component is controlled to mix the sample in the cuvette during the process of transporting the cuvette from the incubation transfer position to the incubation position. While the second transport component is transporting the cuvette, the second transport component is also controlled to mix the sample in the cuvette, saving time by eliminating the need to first dispatch the cuvette to a corresponding mixing mechanism for mixing.

[0171] Step 230: Control the third transport component to transport the cuvette in the transfer position in the second buffer to the measurement position.

[0172] In some embodiments, step 230 controls the third transport component to transport the cuvette in the second buffer transfer position to the measurement position by linear motion in the first direction and the second direction. In some specific embodiments, step 230 controls the second transport component to first transport the cuvette in the second buffer transfer position to the measurement transfer position for reagent addition, and then transport the cuvette after reagent addition in the measurement transfer position to the measurement position.

[0173] In some specific embodiments, in step 230, the third transport component is controlled to mix the sample in the cuvette during the transfer of the cuvette from the second buffer to the measurement position. While the third transport component is transporting the cuvette, the third transport component is also controlled to mix the sample in the cuvette, saving time by eliminating the need to first dispatch the cuvette to the corresponding mixing mechanism for mixing.

[0174] The rapid transport of the reaction cup is achieved by the linear movement of the three transport components. Combined with the two buffer transfer positions, the scheduling path of the reaction cup is simple and direct, which is conducive to speeding up the sample analysis device.

[0175] Finally, let's take the sample analysis device including the first reagent dispensing component 60 with two first reagent needles 61, the second reagent dispensing component 60 with two second reagent needles 61, the reaction component 51 and the measurement component 52 as an example to illustrate the present invention in combination with a specific test item.

[0176] The reaction component 51 has a certain number of reaction cup placement positions, and can heat the sample in the reaction cup located at the reaction cup placement position to incubate the sample. Depending on the test items, some test items will require the addition of a first reagent, such as a mixed reagent. For example, when testing the APTT measurement item based on the coagulation method, the first reagent dispensing component 60 draws the first reagent, such as a mixed reagent, from the reagent carrying component 40, and discharges the drawn first reagent into the reaction cup located at the incubation transfer position 51a of the reaction component 51, thereby completing the mixing of the first reagent and the sample. After completing the addition of the mixed reagent, the second transport component 73 can mix the reaction liquid in the reaction cup, and then place the reaction cup into the reaction component 51, and the reaction component 51 incubates the reaction liquid or the sample in the reaction cup.

[0177] In order to ensure the activity of the reagent, the reagent carrying component 40 usually has a low operating temperature, for example, usually below 16°C. In order to ensure that the coagulation reaction process is sufficient and accurate test results are obtained, the first reagent needs to be heated to about 37°C before being added to the reaction cup and mixed with the sample. In order to improve the test speed of the sample analysis device, it is necessary to complete the heating of the first reagent in a shorter time. Therefore, the two first reagent needles 61 of the first reagent dispensing component 60 have heating components for completing the reagent heating function. Under normal circumstances, the heating time of the reagent takes 4 to 10 seconds. For a high-speed sample analysis device, a single working cycle is, for example, 8 seconds. In this case, the heating time of the reagent will take a long time, which has a great impact on improving the test speed of the sample analysis device. Therefore, in some embodiments of the present invention, the first reagent dispensing component 60 has two first reagent needles 61, and the two first reagent needles 61 respectively draw the first reagent, such as a mixed reagent, from the reagent carrying component 40, move to the incubation transfer position 51a through a linear guide fixed on a linear beam, and add the first reagent, such as a mixed reagent, to the reaction cup in turn. The two first reagent needles 61 are arranged in parallel and move independently. Due to the presence of two independent first reagent needles 61, the operating cycle of the first reagent dispensing unit 60 is doubled to 16 seconds, ensuring that the heating element of the reagent needle has sufficient time to heat the first reagent, ensuring that the reagent temperature reaches a stable 37°C.

[0178] After the sample in the reaction cup is heated and incubated in the reaction component 51 for a fixed time, the reaction cup is transported to the measurement component 52 through the cooperation of the second transport component 73 and the third transport component 75. In some embodiments, the reaction cup can pass through the measurement transfer position 52a on the way for adding a second reagent such as a trigger reagent.

[0179] The third transport component 75 transports the cuvette to the assay transfer station 52a. The second reagent dispensing component 60 draws a second reagent, such as a trigger reagent, from the reagent carrier 40 and moves it above the cuvette held by the third transport component 75. It then adds the second reagent, such as a trigger reagent, to the cuvette, thereby mixing the second reagent with the sample. After the trigger reagent is added, the third transport component 75 mixes the reaction solution in the cuvette. The cuvette is then placed in the assay component 52 for coagulation signal analysis and detection to obtain the test results.

[0180] Similar to the first reagent dispensing component 60, to ensure that the second reagent, such as the trigger reagent, has sufficient heating time, the second reagent dispensing component 60 also has two reagent needles, such as two second reagent needles; these two second reagent needles respectively draw the second reagent, such as the trigger reagent, from the reagent carrying component 40, move to the measurement transfer position 52a via a linear guide fixed to the linear crossbeam, and take turns adding the second reagent, such as the trigger reagent, to the reaction cup. The two second reagent needles 61 are arranged in parallel and move independently. Because there are two independent second reagent needles 61, the working cycle time of the second reagent dispensing component 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating component of the reagent needle has sufficient time to heat the second reagent, so that the reagent temperature reaches a stable 37°C.

[0181] The cuvette in the measuring unit 52 is irradiated with multi-wavelength light. Transmitted or scattered light is received by, for example, a photodetector in the measuring unit 52, which then outputs a detection signal corresponding to the amount of received light. The detection signal can be sent, for example, to the processor 90 for data analysis, processing, and generation of corresponding display content. Sample analysis devices, such as fully automated coagulation analyzers, can utilize various methods for sample analysis, including coagulation, immunoturbidimetry, and chromogenic substrate methods. Depending on the detection method, the measuring unit 52 irradiates the cuvette with light of different wavelengths, for example, ranging from 405 nm to 800 nm.

[0182] The reaction cup that has completed the test can be transferred to the waste recovery device by the third transfer component 75 - the waste recovery device can have, for example, the second cup throwing position mentioned in this article. The third transfer component 75 discards the reaction cup into the second cup throwing position to complete the waste disposal of the reaction cup.

[0183] This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope of this document. For example, the various operational steps and components used to perform the operational steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or incorporated into other steps) depending on the specific application or considering any number of cost functions associated with the operation of the system.

[0184] In the above embodiments, all or part of the embodiments may be implemented through software, hardware, firmware, or any combination thereof. Furthermore, as will be appreciated by those skilled in the art, the principles herein may be embodied in a computer program product on a computer-readable storage medium pre-installed with computer-readable program code. Any tangible, non-transitory computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu-ray discs, etc.), flash memory, and / or the like. These computer program instructions may be loaded onto a general-purpose computer, a special-purpose computer, or other programmable data processing device to form a machine, such that the instructions executed on the computer or other programmable data processing device can generate a device that implements a specified function. These computer program instructions may also be stored in a computer-readable memory, which can instruct the computer or other programmable data processing device to operate in a specific manner, such that the instructions stored in the computer-readable memory can form an article of manufacture, including an implementation device that implements a specified function. The computer program instructions may also be loaded onto a computer or other programmable data processing device, thereby causing the computer or other programmable device to execute a series of operational steps to generate a computer-implemented process, such that the instructions executed on the computer or other programmable device can provide the steps for implementing the specified function.

[0185] Although the principles of this invention have been shown in various embodiments, many modifications of structure, arrangement, proportion, elements, materials and components that are particularly suitable for specific environments and operational requirements can be used without departing from the principles and scope of this invention. The above modifications and other changes or amendments are intended to be included within the scope of this invention.

[0186] The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of this disclosure. Therefore, the present disclosure will be considered in an illustrative rather than a restrictive sense, and all such modifications will be included within its scope. Similarly, the advantages, other advantages and solutions to the problems of the various embodiments have been described above. However, the benefits, advantages, solutions to the problems and any elements that can produce these, or make them more specific, should not be interpreted as critical, required or necessary. The term "comprising" and any other variants used in this article are all non-exclusive inclusions, so that a process, method, article or device that includes a list of elements includes not only these elements, but also other elements that are not explicitly listed or do not belong to the process, method, system, article or device. In addition, the term "coupled" and any other variants used in this article refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections and / or any other connections.

[0187] Those skilled in the art will recognize that many changes can be made to the details of the above embodiments without departing from the basic principles of the invention. Therefore, the scope of the present invention should be determined solely by the claims.

Claims

1. A sample analysis device, characterized in that: include: a housing, the housing comprising a first side along a first direction and a second side along a second direction; a reaction cup loading component, disposed in the housing, for supplying and carrying empty reaction cups to a predetermined location; A sample injection component is provided in the housing and is used to dispatch the sample to be injected to the sample suction position; A sample dispensing component is disposed in the housing and is used to draw the sample from the sample aspirating position and discharge it into the reaction cup located at the predetermined position; a first buffer transfer position for buffering the cuvettes transferred from the predetermined position; a first transport component, which is used to transport the cuvette at the predetermined position to the first buffer transfer position, wherein the first transport component, the cuvette loading component and the first buffer transfer position are independent of each other; an incubation transfer station, which is used to cache the cuvette transferred from the first cache transfer station and facilitate the addition of the first reagent into the cuvette; a reagent carrying component, disposed in the housing and having a plurality of positions for carrying reagent containers; a reagent dispensing component, disposed in the housing, for aspirating a first reagent from the first reagent aspirating position and discharging the first reagent into the reaction cup at the incubation transfer position, wherein the first reagent and the sample are mixed in the reaction cup to form a reaction solution; a reaction component, disposed in the housing, for carrying the reaction cup transferred from the incubation process and incubating the reaction solution in the reaction cup; a second buffer transfer position for caching cuvettes transferred from the reaction component and loaded with incubated reaction liquid; the first buffer transfer position, the incubation transfer position, the second buffer transfer position and the reaction component are independent of each other; a second transfer component, configured to transfer the cuvettes in the first buffer transfer position to the incubation transfer position, transfer the cuvettes in the incubation transfer position to the reaction component, and transfer the cuvettes in the reaction component after incubation of the reaction solution to the second buffer transfer position; a measurement transfer station for caching the cuvette transferred from the second buffer transfer station, wherein the reagent dispensing component is used to aspirate the second reagent from the second reagent aspirating station and discharge it into the cuvette of the measurement transfer station, wherein the reaction solution and the second reagent are mixed in the cuvette to form a sample; a measuring component, disposed in the housing, for carrying a reaction cup and measuring a sample in the reaction cup; the measuring transfer position, the second buffer transfer position, the reaction component, and the measuring component are independent of each other; and The third transport component is used to transport the cuvette in the second buffer transfer position to the measurement transfer position, and to transport the cuvette in the measurement transfer position to the measurement component; wherein: The first cache transfer position is located between the reaction cup loading component and the reaction component, and the second cache transfer position is located between the reaction component and the measurement component; the reaction cup loading component, the first cache transfer position, the reaction component, the second cache transfer position and the measurement component are arranged around the reagent carrying component; the reaction cup loading component, the first cache transfer position and the reaction component are arranged along the first side, and the second cache transfer position and the measurement component are arranged along the second side.

2. The sample analysis device according to claim 1, wherein The first transport component moves linearly along a first direction to transport the reaction cup after sample loading to the first buffer for transfer.

3. The sample analysis device according to claim 1, wherein: The second transport component transports the cuvette transferred in the first buffer to the reaction component and transports the cuvette incubated with the reaction solution in the reaction component to the transfer position in the second buffer by linear motion along the first direction and the second direction.

4. The sample analysis device according to claim 1, wherein the second transport component further mixes the sample in the reaction cup during the process of transferring the reaction cup from the incubation position to the reaction component.

5. The sample analysis device according to claim 1, wherein: The third transport component transports the cuvette transferred in the second buffer to the measuring component by linear motion along the first direction and the second direction.

6. The sample analysis device according to claim 1, wherein: The third transport component further includes a mixing component for mixing the sample in the reaction cup during the process of the reaction cup being transferred from the assay center to the assay component.

7. The sample analysis device according to any one of claims 1 to 6, wherein: The first transport component, the second transport component and the third transport component all include a cup grabbing hand and a driving component for driving the cup grabbing hand to move.

8. The sample analysis device according to claim 7, wherein: The reagent dispensing component includes a first group of reagent needles and a second group of reagent needles; the first group of reagent needles is arranged in a manner of linear motion between the reagent aspirating position and the incubation transfer position, the first group of reagent needles is used to aspirate reagents from the reagent aspirating position and discharge them into a reaction cup located in the incubation transfer position, and the first group of reagent needles includes at least one reagent needle; the second group of reagent needles is arranged in a manner of linear motion between the reagent aspirating position and the measurement transfer position, the second group of reagent needles is used to aspirate reagents from the reagent aspirating position and discharge them into a reaction cup located in the measurement transfer position, and the second group of reagent needles includes at least one reagent needle; The direction in which the second transport component grabs the reaction cup is greater than 90 degrees to the direction in which the first set of reagent needles moves linearly; The direction in which the third transport component grabs the reaction cup is greater than 90 degrees to the direction in which the second group of reagent needles move linearly.

9. The sample analysis device according to claim 7, wherein: The cup grabbing hand of the first transport component grabs the reaction cup along the second direction; the cup grabbing hand of the second transport component grabs the reaction cup along the second direction; and the cup grabbing hand of the third transport component grabs the reaction cup along the first direction.

10. The sample analysis device according to claim 9, wherein: The first direction is perpendicular to the second direction.

11. The sample analysis device according to claim 1, wherein: The reaction component is rectangular in shape and has a plurality of reaction cup placement positions; the determination component is rectangular in shape and has a plurality of reaction cup placement positions.

12. A method of a sample analysis device, characterized in that, The sample analysis device is the sample analysis device according to any one of claims 1 to 11; the method comprises: Controlling the sample dispensing component to absorb the sample from the sample aspirating position and discharge the sample into the reaction cup located at the predetermined position; Controlling the first transport component to transport the cuvette loaded with the sample at the predetermined position to the first buffer for transfer; Controlling the second transport component to transport the cuvette at the first buffer transfer position to the incubation transfer position; Controlling the reagent dispensing component to absorb the first reagent from the first reagent aspirating position and discharge it into the reaction cup at the incubation transfer position, wherein the first reagent and the sample are mixed in the reaction cup to form a reaction solution; Controlling the second transport component to transport the cuvette in the incubation position to the reaction component; Controlling the second transport component to transport the cuvette in which the reaction solution incubation in the reaction component has been completed to the transfer position in the second buffer; controlling the third transport component to transport the cuvette at the second buffer transfer position to the measurement transfer position; Controlling the reagent dispensing component to absorb the second reagent from the second reagent aspirating position and discharge it into the reaction cup at the measurement intermediate position, where the second reagent and the reaction solution are mixed to form a sample in the reaction cup; The third transport unit is controlled to transport the cuvette in the measurement process to the measurement unit for measurement.

13. The method according to claim 12, wherein: The controlling the first transport component to transport the cuvette loaded with the sample at the predetermined position to the first buffer transfer position includes: The first transport component is controlled to move linearly along a first direction to transport the reaction cup after sample loading to the first buffer for transfer.

14. The method according to claim 12, wherein: The controlling the second transport component to transport the cuvette at the first buffer transfer position to the incubation transfer position includes: The second transport component is controlled to transport the reaction cup at the first buffer transfer position to the incubation transfer position through linear motion along the first direction and the second direction.

15. The method according to claim 12, wherein The controlling the second transport component to transport the cuvette in which the reaction solution incubation in the reaction component has been completed to the second buffer transfer position includes: The second transport component is controlled to move linearly along the first direction and the second direction to transport the reaction cup in which the reaction liquid incubation in the reaction component has been completed to the second buffer for transfer.

16. The method according to claim 12, wherein The controlling the second transport component to transport the cuvette in the incubation transfer position to the reaction component further includes: During the process of transferring the reaction cup from the incubation center to the reaction component, the second transport component is controlled to mix the reaction solution in the reaction cup.

17. The method according to claim 12, wherein The controlling the third transporting component to transport the cuvette at the second buffer transfer position to the assay transfer position includes: The third transport component is controlled to transport the cuvette at the second buffer transfer position to the measurement transfer position through linear motion along the first direction and the second direction.

18. The method according to claim 12, wherein The controlling the third transporting unit to transport the cuvette in the measurement process to the measurement unit for measurement further includes: During the process of transferring the cuvette from the assay center to the assay component, the third transport component is controlled to mix the sample in the cuvette.

19. A computer-readable storage medium, characterized in that The method comprises a program which can be executed by a processor to implement the method according to any one of claims 12 to 18.

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