A high liquid-repellent polystyrene material and a preparation method thereof

Abstract

The application discloses a kind of high lyophobic polystyrene material and preparation method thereof, including following weight parts of each component: polystyrene 100 parts;Anti-antigen collection liquid lyophobic agent 0.5-2 parts;Titanium dioxide 0.3-5 parts.The preparation method of high lyophobic polystyrene material disclosed in the application includes the following steps: S1, according to weight ratio, each component is weighed: high impact polystyrene (HIPS) 100 parts;Collection liquid lyophobic agent 0.5-5 parts;Titanium dioxide 0.3-5 parts;S2, after each component in step S1 is fully mixed, it is extruded by double screw extruder and granulated to obtain the high lyophobic polystyrene material.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of high molecular materials, in particular, to a high-sampling liquid polystyrene material and a preparation method thereof. BACKGROUND

[0002] Clinically, whether the virus invades the human body can be judged by mainly applying three ways of nucleic acid detection, antigen detection and antibody detection, among which nucleic acid detection and antigen detection can directly detect viruses. Antigen detection is a main means for rapid detection of viruses or pathogens, which is simple to operate, fast in result, suitable for home detection and one of the most convenient, fast and efficient means. The way of antigen detection is that after sampling by a swab in the nose or pharynx, the swab is quickly put into a processing bottle and fully stirred with a sampling liquid, and then the sampling liquid is dropped into a detection card hole for three times, the sampling liquid climbs along the test strip in the detection card box, and the result can be quickly judged according to the display of the quality control area.

[0003] However, compared with nucleic acid detection and antibody detection, the accuracy of antigen detection is relatively low, so the antigen sampling liquid needs to be adsorbed on the periphery of the detection test strip for a long time and effectively, so as to provide sufficient sampling liquid for the detection test strip. However, because the sampling liquid is generally prepared from high-polarity materials such as tris-hydroxymethyl aminomethane hydrochloride, polysorbate, antigen sampling liquid (phosphate buffered saline), polyethylene glycol hexadecyl ether and purified water, the shell material of the antigen detection box needs to have a certain sampling liquid repellency to ensure that the liquid drops are adsorbed on the periphery of the test strip for a long time without diffusion and flow along the detection box. However, since polystyrene is a polar material with strong hydrophilicity, the sampling liquid is prone to diffusion, thereby affecting the detection accuracy.

[0004] It is necessary to provide a polystyrene material with strong sampling liquid repellency to ensure that the sampling liquid can be fully attached to the periphery of the test strip, and such strong liquid repellency and high adhesion can effectively improve the detection accuracy. In the prior art, there are many related to the appearance and structure design of the antigen kit, the type of test strip and the preparation of the sampling liquid, such as patents CN307637164S, CN112129936A, CN114742993A, CN112129937A, CN111024954A, CN111190005A, etc., but there is no related report on the shell material of the detection box for improving the detection accuracy. SUMMARY

[0005] In view of the defects in the prior art, the purpose of the present application is to provide a high-sampling liquid polystyrene material for improving the accuracy of antigen detection and a preparation method thereof. The sampling liquid of the high-liquid-repellent polystyrene material of the present application has a rolling angle of more than 60°, has a significant resistance to sampling liquid diffusion, effectively helps the sampling liquid to gather around the test strip, and is mainly applied in the field of antigen detection box shells.

[0006] The object of the present application is achieved by the following technical solutions.

[0007] The present application provides a high liquid-repellent polystyrene material, comprising the following components by weight:

[0008] Polystyrene (HIPS) 100 parts;

[0009] Antigen collection liquid repellent 0.5-2 parts;

[0010] Titanium dioxide 0.3-5 parts.

[0011] Preferably, the polystyrene is high impact polystyrene (HIPS).

[0012] The high impact polystyrene has a melt index of 3-10 g / 10 min under test conditions of 200℃*5 kg.

[0013] Preferably, the antigen collection liquid repellent is a polystyrene-polysiloxane-polystyrene triblock copolymer.

[0014] The number average molecular weight of the polystyrene-polysiloxane-polystyrene triblock copolymer is 15000-20000. The product provided by Polymersource Company of Canada can be used, and it is purchased from Angxing New Carbon Material Changzhou Co., Ltd.

[0015] Preferably, the titanium dioxide is nano titanium dioxide treated with aluminum hydroxide and stearic acid, and the rutile titanium dioxide JWN-OR15 with a particle size of 15 nm produced by Jiwei Nano New Material can be used.

[0016] The present application also provides a preparation method of a high liquid-repellent polystyrene material, comprising the following steps:

[0017] S1, each component is weighed according to the weight ratio: polystyrene (HIPS) 100 parts; collection liquid repellent 0.5-5 parts; nano titanium dioxide 0.3-5 parts;

[0018] S2, after the components in step S1 are fully mixed, they are extruded by a double screw extruder and granulated to obtain the high liquid-repellent polystyrene material.

[0019] The rotation speed of the double screw extruder is 450-600 rpm, and the temperature is 160-190℃.

[0020] The present application also provides a high liquid-repellent polystyrene material for use on the shell of an antigen detection box.

[0021] Compared with the prior art, the present application has the following beneficial effects:

[0022] 1. The application of polystyrene-polysiloxane-polystyrene triblock copolymer as a liquid repellent for the collection liquid, the polystyrene segment in the block copolymer can be fully compatible with polystyrene, the non-polar polysiloxane segment is separated from the surface of polystyrene, which gives the polystyrene material super strong liquid repellency, especially for the antigen collection liquid with high metal ion content. The polystyrene segment is fully compatible with polystyrene resin, which does not affect the performance of polystyrene material and ensures that the antigen reagent box does not break during use.

[0023] 2. Because the antigen reagent box is white, titanium dioxide needs to be selected to adjust the color, but titanium dioxide itself has strong hydrophilicity, which affects the liquid repellency of the material. In this scheme, nano titanium dioxide treated by aluminum hydroxide and stearic acid is selected, which reduces the influence of titanium dioxide on the hydrophobicity of the material from two aspects: first, the application of nano titanium dioxide improves the dispersibility of titanium dioxide in HIPS matrix resin. Under the premise of reducing the addition amount of titanium dioxide by 20%, the same whiteness can be achieved, which can reduce the influence of titanium dioxide with high liquid affinity on the liquid repellency from the amount; second, the treatment of titanium dioxide with aluminum hydroxide and stearic acid reduces the hydrophilicity and has certain liquid repellency.

[0024] 3. The roll-off angle of the collection liquid of the high liquid repellent polystyrene material of the application is more than 60°, which has significant resistance to collection and diffusion capacity, effectively helps the collection liquid to gather around the test strip, the production process is simple, and it is mainly applied to the field of antigen detection box shell. DETAILED DESCRIPTION

[0025] The application will be described in detail below in conjunction with the examples. The following examples will help those skilled in the art to further understand the application, but do not limit the application in any form. It should be pointed out that for those skilled in the art, without departing from the concept of the application, a number of adjustments and improvements can be made. These all belong to the protection scope of the application.

[0026] Example 1

[0027] The component allocation ratio of examples 1-5 and comparative examples 1-5 is shown in table 1.

[0028] The high impact polystyrene used in examples 1-5 and comparative examples 1-5 is 622P from Shanghai Sike Petroleum Chemical Co., Ltd., and the melt index (200℃×5KG) is 4.5g / 10min.

[0029] The liquid-liquid agent used in the above examples 1-5 and comparative examples 1-5 is polystyrene-polydimethylsiloxane-polystyrene triblock copolymer (PS-PDMS-PS), which can be selected from the product provided by Polymersource Company of Canada and purchased from Angxing New Carbon Material Changzhou Co., Ltd.

[0030] The titanium dioxide used in the above examples 1-5 and comparative examples 1-5 is nano titanium dioxide which is surface treated by aluminum hydroxide and stearic acid, and can be selected from rutile titanium dioxide JWN-OR15 produced by Jiwei Nano New Material Co., Ltd., with a particle size of 15 nm.

[0031] The polysiloxane used in the above comparative examples 1-5 can be selected from DC-200 produced by Wengjiang Chemical Co., Ltd.

[0032] The polystyrene-polydimethylsiloxane diblock copolymer (PS-PDMS) used in the above comparative examples 1-5 can be selected from the product provided by Polymersource Company of Canada and purchased from Angxing New Carbon Material Changzhou Co., Ltd.

[0033] The titanium dioxide used in the above comparative examples 1-5 is nano titanium dioxide which is not surface treated, and can be selected from rutile titanium dioxide JWN-R15 produced by Jiwei Nano New Material Co., Ltd., with a particle size of 15 nm.

[0034] The rutile titanium dioxide used in the above comparative examples 1-5 has a particle size of 0.23 μm and is surface treated by aluminum oxide, and can be selected from R-103 produced by DuPont Company.

[0035] The preparation method of the above examples 1-5 and comparative examples 1-5 is as follows:

[0036] S1, each component is weighed according to the weight ratio: high impact polystyrene (HIPS) 100 parts; liquid-liquid agent 0.5-5 parts; nano titanium dioxide 0.3-5 parts.

[0037] S2, after the components in step S1 are fully mixed by a high-speed mixer, they are extruded and granulated by a twin-screw extruder, the rotating speed of which is 450-600 rpm and the temperature is 160-190℃.

[0038] Table 1 (unit: weight fraction)

[0039]

[0040] The rolling angle test results of the PBS solution of the materials prepared in the above examples 1-5 and comparative examples 1-5 are shown in Table 2 below.

[0041] Table 2

[0042]

[0043] It can be found from the data in Table 2 that the roll-off angle of the antigen collection liquid of the high-lyophobic antigen collection liquid type polystyrene material (Examples 1-5) of the application is increased by more than 40% compared with that of the common polystyrene material (Comparative Example 1). The styrene segment of the polystyrene-polydimethylsiloxane-polystyrene triblock copolymer (PS-PDMS-PS) is compatible with the polystyrene matrix, and the non-polar polydimethylsiloxane can be effectively precipitated on the surface of the polystyrene, imparting high lyophobicity to the surface of the polystyrene. It is the application of the triblock copolymer that makes the non-polar siloxane more prominent on the surface of the polystyrene, and the lyophobicity of the antigen collection liquid of the polystyrene is stronger than that of the common polydimethylsiloxane (Comparative Example 2) and the diblock copolymer (Comparative Example 3). Because the antigen detection box is a white product, titanium dioxide is necessarily used for dyeing. The high polarity and high lyophilicity of titanium dioxide itself lead to a decrease in the roll-off angle after the addition of titanium dioxide. The nano-titanium dioxide treated with aluminum hydroxide and stearic acid is first imparted with lipophilicity on the surface of the titanium dioxide, which reduces the influence of the titanium dioxide on the lyophobicity of the polystyrene surface compared with the untreated titanium dioxide (Comparative Example 4). Secondly, the nano-titanium dioxide has stronger dispersibility, and the nano effect leads to better lyophobicity. In addition, the use amount of the titanium dioxide can be reduced, which further reduces the influence of the titanium dioxide on the lyophobicity of the polystyrene surface (Comparative Example 5).

[0044] The specific embodiments of the application are described above. It should be understood that the application is not limited to the specific embodiments described above, and various modifications or changes can be made by those skilled in the art within the scope of the claims, which do not affect the essential content of the application.

Claims

1. A highly hydrophobic polystyrene material for the outer shell of an antigen detection kit, characterized in that, The components include the following parts by weight: 100 parts of polystyrene; 0.5-2 parts of the antigen collection solution and its phobic agent; Titanium dioxide 0.3-5 parts; The phobic agent in the antigen collection solution is a polystyrene-polysiloxane-polystyrene triblock copolymer. The number-average molecular weight of the polystyrene-polysiloxane-polystyrene triblock copolymer is 15,000-20,000. The titanium dioxide is nano-titanium dioxide that has undergone surface treatment with aluminum hydroxide and stearic acid; The polystyrene is high-impact polystyrene; The high-impact polystyrene, under test conditions of 200℃ × 5kg, has a melt index of 3-10g / 10min.

2. A method for preparing a highly hydrophobic polystyrene material according to claim 1, characterized in that, Includes the following steps: S1. Weigh the following components according to the weight ratio: 100 parts of polystyrene HIPS; 0.5-5 parts of liquid repellent; 0.3-5 parts of nano titanium dioxide; S2. After thoroughly mixing all components in step S1, the mixture is extruded and granulated using a twin-screw extruder to obtain the highly hydrophobic polystyrene material.

3. The preparation method according to claim 2, characterized in that, In step 2, the twin-screw extruder rotates at 450-600 rpm and is heated at 160-190℃.

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