A method of providing control data for a laser device for non-destructive laser-induced property change of a polymer structure

Abstract

The invention relates to a method for providing control data for a laser device (10) for non-destructive laser-induced property change of a polymer structure (14). As a step, the method comprises determining (S10) a respective range of irradiation parameters for a preset irradiation parameter of the laser device (10) by an irradiation model, wherein a property change model is provided in the irradiation model, wherein an induced property change of the polymer structure (14) is modeled depending on the irradiation parameter, wherein a destruction threshold model is provided in the irradiation model, wherein at least one threshold value for a laser-induced optical penetration of the polymer structure is modeled depending on an irradiation parameter; and wherein the property change resulting from the property change model is optimized while being limited by the threshold value from the destruction threshold model to determine the range of irradiation parameters.

Description

Technical Field

[0001] The invention relates to a method for providing control data of a laser device for non-destructive laser-induced property changes in polymer structures, a laser device with a control device configured to carry out the method, and a computer program and a computer-readable medium. Background Art

[0002] Methods for corresponding non-surgical and non-destructive property changes of polymer structures are known in ophthalmology. Here, for example, laser-induced refractive index change (LIRIC) is classified therein, in which the polymer structure of artificial or biological tissue is changed by laser irradiation, so that a phase change of light can be achieved, which is used to achieve a refractive index change for correcting visual impairments. By non-destructive, it is meant that the macroscopic shape of the polymer structure, such as the cornea or intraocular lens, is not changed. This means that no microlenses are cut out of the polymer structure in order to achieve the refractive index change. Therefore, this method can also be called non-surgical. Another exemplary method for non-destructive laser-induced property changes is the so-called "crosslinking" method, in which crosslinks of the polymer structure are produced by laser irradiation, which increase the mechanical stability. Summary of the Invention

[0003] The present invention is based on the object of providing a range of irradiation parameters for non-destructive laser-induced property changes in polymer structures.

[0004] This object is solved by the method according to the invention, by the device according to the invention and by the computer program according to the invention. Advantageous developments are described in the dependent claims, the description and the drawings.

[0005] The invention is based on the idea of ​​creating an illumination model for determining an illumination parameter range, wherein the characteristic changes are modeled depending on the illumination parameter, wherein the illumination parameter is limited by corresponding threshold values ​​obtained from another model, such as a thermal model and / or a model simulating optical penetration.

[0006] A first aspect of the present invention relates to a method for providing control data for a laser device for non-destructive laser-induced property changes in polymer structures. The method can be performed, for example, by a control device or a computing device. A control device can be understood as a device, device assembly, or device group configured and arranged to receive and evaluate signals and generate control signals. For example, the control device can be configured as a control device, a control chip, or a computer program. The method includes, as steps, determining corresponding irradiation parameter ranges for predetermined irradiation parameters of the laser device using an irradiation model, wherein the irradiation model provides a property change model, wherein the induced property change of the polymer structure is modeled as a function of the irradiation parameters, wherein a damage threshold model is provided in the irradiation model, wherein at least one threshold value for laser-induced damage to the polymer structure is modeled as a function of the irradiation parameters, and wherein the property change induced by the property change model is calculated or optimized while being limited by a threshold value from the damage threshold model to determine the irradiation parameter range. Finally, control data can be provided for the laser device, wherein the control data includes the determined irradiation parameter ranges.

[0007] In other words, the irradiation model can be used to determine the range of irradiation parameters that can achieve non-destructive laser-induced property changes in polymer structures. In this context, non-destructive means that the macroscopic shape of the polymer structure remains stable, where the polymer structure can be biological or artificial. For example, artificial optical lenses and / or the cornea / lens of the human or animal eye can be constructed from polymer structures.

[0008] The irradiation parameters that are adjusted for the property changes and determine the corresponding irradiation parameter ranges may include, for example, numerical aperture, pulse length, energy, wavelength, repetition rate, pulse path distance, and / or pulse distance between individual pulses. In the irradiation model, a property change model may be provided, in which mathematical / physical modeling is performed of the property changes that the polymer structure undergoes under preset irradiation parameters. For example, a phase change in a polymer structure may be modeled as a function of the irradiation parameters in laser-induced refractive index change (LIRIC). In addition, a damage threshold model may be provided, with the aid of which laser-induced damage to the polymer structure, in particular optical penetration or cavitation bubbles and / or thermal denaturation, may be modeled as a function of the corresponding irradiation parameters. This means that two antagonistic models are provided, one of which describes the effect of the property changes and the other describes the damage threshold of the polymer structure. A preferred irradiation parameter range can then be determined from the optimization of these two models, wherein the irradiation parameters are preferably optimized so that the property changes are maximized without causing damage to the polymer structure. The irradiation parameter range thus obtained can then be provided to the control of the laser device via control data.

[0009] The present invention provides the advantage of determining and defining a "corridor" for all irradiation parameters, thereby achieving significant property-changing effects without damaging the polymer structure. This allows for improved processing of biopolymer structures and reduces the processing costs of artificial polymer structures.

[0010] The present invention also includes configurations that produce additional advantages.

[0011] In one configuration, control data for a laser-induced refractive index change (LIRIC) of a polymer structure and / or a crosslinking method for a polymer structure are provided. In laser-induced refractive index change (LIRIC), the refractive index of the human or animal eye is changed by laser irradiation without removing tissue from the eye. Here, a lens is incorporated into the cornea, wherein the molecular structure of the polymer structure is changed. In addition, the laser-induced refractive index change can also be performed on artificial structures to produce their lens properties. The crosslinking method is an application in which not only visual disorders but also a variety of other disease modes, such as keratoconus, can be treated. In the crosslinking method, the crosslinking connections of the polymer structure are increased, which increases the stability. In this form of configuration, the advantage is that the method can be used for preferred application forms.

[0012] Another form of configuration provides control data for a solid-state laser, particularly a fiber laser or crystal laser. In a solid-state laser, a crystal or glass is doped with ions, wherein these ions provide the active medium of the solid-state laser. Optical excitation of these ions can generate laser radiation, for example, by diode-pumped solid-state lasers. An example of a crystal laser is a so-called yttrium aluminum garnet laser (YAG laser), although these lasers can be very expensive. Therefore, a fiber laser is preferred. By fiber laser, it is understood that a device, device group, or device component can include a fiber oscillator and / or a fiber amplifier. Fiber lasers combine many of the advantages of individual laser types without the corresponding disadvantages, so using fiber lasers for kerf-free property modification methods has considerable advantages. Fiber lasers offer the desired flexibility in irradiation parameters, particularly the generation of variable repetition rates and variable / short pulse durations, with the desired stability of irradiation parameters, particularly energy, pulse duration, repetition rate, and pulse shape, and with increased freedom from maintenance. In particular, many irradiation parameters can be more easily achieved with fiber lasers. This form of configuration has the advantage that the determined irradiation parameters can be adjusted more precisely.

[0013] Another advantageous configuration provides a numerical aperture between 0.15 and 0.35, in particular between 0.2 and 0.3, a pulse length between 10 femtoseconds and 90 femtoseconds, in particular between 30 femtoseconds and 75 femtoseconds, an energy between 5 nanojoules and 95 nanojoules, in particular between 20 nanojoules and 80 nanojoules, a wavelength between 300 nanojoules and 1500 nanojoules, in particular between 900 nanojoules and 1100 nanojoules, and a repetition rate between 100 kHz and 100 MHz, in particular between 5 MHz and 75 MHz, as control data for the laser-induced refractive index change (LIRIC). In other words, for the aforementioned irradiation parameters, indicated irradiation parameter ranges are provided for an optimized LIRIC, which can then be used for controlling the laser device, wherein the corresponding limit values ​​are also included in the corresponding ranges. Therefore, intermediate values ​​within the respective irradiation parameter ranges are also considered disclosed.

[0014] Another configuration provides the control data with a pulse distance along the scanning direction between 1 nanometer and 10 microns, particularly between 10 nanometers and 1 micron. This means that the illumination parameter range for the pulse distance lies between the aforementioned limits, with the limits also being included in the corresponding range. The illumination parameter ranges mentioned here can also be preferably used in conjunction with the aforementioned illumination parameter ranges to achieve a preferred refractive index change. For example, the pulse distance can be adjusted by appropriately adjusting the repetition rate and scanning speed.

[0015] Preferably, the control data include pulse path distances of respective adjacent laser pulse paths between 10 nanometers and 50 micrometers, in particular between 50 nanometers and 5 micrometers. This means that the pulse path distances are adjusted over the aforementioned irradiation parameter ranges in spatial directions that do not extend along the scanning direction to achieve optimal irradiation parameters, in particular for refractive index variations in polymer structures.

[0016] Another configuration provides that, when determining the radiation parameter range, the radiation parameter is limited from a threshold value by a preset factor. In other words, in model optimization, particularly in a damage threshold model, the irradiation parameter can be limited from the threshold value by a preset factor, wherein the factor can be greater than or equal to 1 when the threshold value is divided by the factor and can be less than 1 when the threshold value is multiplied by the factor. This means that a safe distance from the threshold value can be taken into account by the preset factor, so that the irradiation parameter remains below the threshold value. This configuration can improve the safety of irradiation of polymer structures.

[0017] Another configuration provides control data for varying the properties of a biopolymer, particularly the cornea of ​​a human or animal eye. In other words, the polymer structure is a biopolymer, and the range of irradiation parameters is defined. This advantageously allows for improved treatment of the human or animal eye.

[0018] In another embodiment, control data for varying the properties of a plastic polymer are provided, in particular for producing an intraocular lens. In other words, the polymer structure is a plastic polymer. This embodiment allows, in particular, improved production of intraocular lenses.

[0019] Another preferred embodiment provides that the energy and / or laser pulse distance for producing the property change of the polymer structure is provided by a variably variable value within the corresponding irradiation parameter range in the control data, wherein the further irradiation parameter remains constant within its irradiation parameter range. This means, for example, that the energy and / or laser pulse distance can be varied within the respectively determined irradiation parameter range for different property changes, in particular a refractive index change depending on the irradiation position, while the further irradiation parameters, such as the numerical aperture, pulse length and / or wavelength, are fixed to a set value within the corresponding irradiation parameter range. As a result, the desired effect can be achieved more simply and better.

[0020] A second aspect of the present invention relates to a method for controlling a laser device for non-destructive laser-induced refractive index change (LIRIC) of polymer structures, comprising controlling the laser device by means of a control device so that it emits pulsed laser pulses into the polymer structure in a shot sequence in a predetermined pattern, wherein the laser pulses are emitted for non-destructive refractive index change of the polymer structure, with a numerical aperture between 0.15 and 0.35, a pulse length between 10 fs and 90 fs, an energy between 5 nJ and 95 nJ, a wavelength between 300 nm and 1500 nm, and a repetition rate between 100 kHz and 100 MHz, wherein the wavelength can particularly preferably be selected between 800 nm and 1450 nm, in particular between 900 nm and 1100 nm, in order to operate the laser within the preferred wavelength range for laser-induced refractive index change. In other words, a method is provided in which the laser device is controlled by means of the control data provided in the previous aspect. Particularly preferably, the wavelength can be between 800 nm and 1450 nm. Further advantageous configurations of this aspect of the invention can be derived from the configuration of the first aspect of the invention, with the same advantages and possibilities for variations resulting.

[0021] A third aspect of the present invention relates to a control device, which is configured to carry out one of the above-described embodiments of the method according to the invention. The advantages described above arise. The control device can be configured, for example, as a control chip, a control device or an application ("app"). The control device can preferably include a processor device and / or a data memory. By processor device, it is understood that there is a device or device component for electronic data processing. The processor device can, for example, include at least one microcontroller and / or at least one microprocessor. Preferably, the program code for carrying out the method according to the invention can be stored on an optional data memory. The program code can then be configured to cause the control device to carry out one of the above-described embodiments of the method according to the invention when the processor device is executed.

[0022] A fourth aspect of the present invention relates to a laser device having at least one control device. The control device can be configured to execute one of the aforementioned embodiments of the method according to the invention. The advantages described above arise. The control device can be configured, for example, as a control chip, a control device, or an application ("app"). The control device can preferably include a processor device and / or a data memory. By processor device is understood a device or device component for electronic data processing. The processor device can, for example, include at least one microcontroller and / or at least one microprocessor. Preferably, the program code for executing the method according to the invention can be stored on an optional data memory. The program code can then be configured so that, when executed by the processor device, the control device executes one of the aforementioned embodiments of the method according to the invention. The advantages described above arise.

[0023] In an advantageous configuration of the laser device, the laser device includes a solid-state laser, in particular a fiber laser. A fiber laser is understood to include a device, device assembly, or device component that includes a fiber oscillator and / or a fiber amplifier. Fiber lasers combine many of the advantages of individual laser types without the corresponding disadvantages, and therefore the use of fiber lasers for non-destructive laser-induced property changes in polymer structures offers considerable advantages. Fiber lasers offer the required flexibility with respect to parameter space (particularly, for example, variable repetition rate and variable / short pulse duration), the required parameter stability (particularly, for example, pulse energy, pulse duration, repetition frequency, and pulse shape), and increased maintenance freedom (for example, air cooling ("air-cooled") and long lifetime). This flexibility in parameter space means that many parameters can be more easily achieved with fiber lasers. The fiber oscillator and fiber amplifier can, for example, be encompassed by the fiber laser according to the present invention, but can also be, for example, a fiber oscillator and a solid-state amplifier. By using fiber lasers, which have been used in the prior art only for microlens removal, the present invention optimizes non-surgical or incision-free methods over surgical and thus invasive methods.

[0024] In a further advantageous configuration of the laser device according to the present application, the laser device can be adapted to emit laser pulses with a wavelength range between 300 nm and 1500 nm, preferably between 900 nm and 1100 nm, a corresponding pulse duration between 10 fs and 90 fs, preferably between 30 fs and 75 fs, and a repetition frequency of more than 10 kHz (kHz), preferably between 100 kHz and 100 MHz. The above-mentioned advantages have occurred.

[0025] In a further advantageous configuration of the laser device according to the present application, the control device can comprise at least one storage device for at least temporarily storing at least one control data set, wherein the one or more control data sets comprise control data for positioning, and / or focusing, and / or for irradiation parameter adjustment of a single laser pulse; and can comprise at least one beam device for beam guidance, and / or beam shaping, and / or beam deflection, and / or beam focusing of the laser beam of the laser. Wherein the above-mentioned control data sets are preferably generated based on the first aspect of the present application and / or a measured topography and / or a thickness measurement and / or a morphology.

[0026] Further features and advantages can be derived from the description of the first inventive aspect, wherein advantageous configurations of each inventive aspect are to be considered as beneficial configurations of the respective other inventive aspects.

[0027] A fifth aspect of the present application relates to a computer program comprising instructions to cause a laser device according to the third inventive aspect to perform the method steps according to the first and / or second inventive aspect.

[0028] A sixth aspect of the present application relates to a computer readable medium on which the computer program according to the fifth inventive aspect is stored. Further features and advantages can be derived from the description of the first to fourth inventive aspects, wherein advantageous configurations of each inventive aspect are to be considered as beneficial configurations of the respective other inventive aspects. BRIEF DESCRIPTION OF DRAWINGS

[0029] Further features of the invention are apparent from the claims, the drawings and the description of the drawings. The features and feature combinations mentioned in the above description and the features and feature combinations mentioned below in the description of the figures and / or shown individually in the figures are usable not only in the respectively specified combination but also in other combinations without departing from the scope of the invention. Therefore, embodiments are also to be regarded as covered and disclosed by the invention, which are not explicitly shown and explained in the figures, but which result from and can be derived from the feature combinations separated from the explained embodiments. Embodiments and feature combinations are also to be regarded as disclosed and therefore do not include all features of the originally proposed independent claims. Furthermore, embodiments and feature combinations are to be regarded as disclosed, in particular by means of the embodiments described above, which go beyond or deviate from the feature combinations described in the claim relationship. Shown:

[0030] Figure 1 is a schematic diagram of a laser device according to an exemplary embodiment;

[0031] Figure 2 is a schematic diagram of a method according to an exemplary embodiment.

[0032] In the figures, identical or functionally identical elements are provided with the same reference symbols. DETAILED DESCRIPTION

[0033] Figure 1 A schematic diagram of a laser device 10 having a laser 12, in particular a solid-state laser, is shown for non-destructive laser-induced property changes in a polymer structure 14. In this embodiment, the polymer structure 14 can be a biopolymer, in particular a region of the cornea 14 of a human or animal eye 16, and the property change can be a laser-induced refractive index change (LIRIC) of the cornea 14. The laser pulse sequence, laser pulse profile, and irradiation parameters for the refractive index change of the cornea 14 can be provided by a control device 18 in the form of control data, so that the laser 12 emits pulsed laser pulses at laser pulse positions predetermined by the control data, wherein the irradiation parameters are provided by the control data to achieve the refractive index change. Alternatively, the control device 18 can be a control device 18 external to the laser device 10.

[0034] also, Figure 1 It is shown that a laser beam 20 generated by laser 12 can be deflected toward eye 16 by means of a beam deflection device 22, ie a beam deflection device (eg a rotating scanner), to produce a refractive index change in cornea 14. Beam deflection device 22 can also be controlled by control device 18.

[0035] Preferably, the laser 12 shown may be a fiber laser, which is formed at least to emit laser pulses having a wavelength in the range between 300 nm and 1500 nm, preferably between 900 nm and 1100 nm, a corresponding pulse duration between 10 femtoseconds and 90 femtoseconds, preferably between 30 femtoseconds and 75 femtoseconds, and a repetition rate greater than 10 kHz, preferably between 100 kHz and 100 MHz.

[0036] Optionally, the control device 18 further comprises a storage device (not shown) for at least temporarily storing at least one control data set, wherein the one or more control data sets comprise control data for adjusting irradiation parameters, positioning and / or focusing of a single laser pulse in the eye 16.

[0037] In laser-induced refractive index changes, as well as in other non-surgical methods for property changes of polymer structures 14, such as cross-linking methods, it is provided to maximize the property change effect of each laser pulse without damaging the polymer structure 14. In particular, in the case of excessively high energy densities, cavitation bubbles may be generated, which must be avoided. In order to obtain optimal irradiation parameters, the control device 18 can therefore perform Figure 2 The method shown.

[0038] exist Figure 2 , a schematic diagram of a method for providing a laser device 10 with control data for a non-destructive laser-induced property change of a polymer structure is shown, where in this embodiment, the polymer structure can be the cornea 14 of an eye 16 and the property change can be a laser-induced refractive index change (LIRIC).

[0039] In step S10, the control device 18 may determine an optimal irradiation parameter range for the corresponding irradiation parameters, where the irradiation parameters may include, for example, numerical aperture, pulse length, energy, wavelength, repetition rate, pulse distance, and / or pulse path distance. To determine the optimal irradiation parameter range, an irradiation model may be used, which provides a characteristic change model and a damage threshold model. In this embodiment, the characteristic change model may be a LIRIC model, which describes the phase change induced by laser irradiation. Specifically, the phase change may be determined using the following formula:

[0040] Δφ=γ·P avg m ·NA 2(m-2) ·m m-2 ·υ 1-m ·τ 1-m ·λ write 3-2m ·λ read -1 ·S -1 ·t -1

[0041] where ΔΦ is the induced phase transition, γ is the material constant, and P avg is the average power of the laser, NA is the numerical aperture of the laser device 10, m is the order of multiphoton absorption, ν is the repetition frequency of the laser 12, τ is the pulse duration, λ read is the wavelength of the laser radiation 20, λ write is the wavelength to provide the phase change, S is the scanning speed, and t is the pulse path distance.

[0042] In this embodiment, the damage threshold model describing the threshold of laser-induced damage to the polymer structure can be a modeling of optical penetration, wherein the model of optical penetration can be given by the following formula:

[0043]

[0044] Among them E TH represents the pulse energy threshold for optical penetration, and M2 represents the beam quality. Alternatively or additionally, other damage threshold models describing polymer structural damage may be considered, such as thermal models.

[0045] In order to determine the optimal illumination parameter range from the illumination model, it is preferred to provide a maximized phase change without initiating optical penetration.

[0046] As step S12, the control data determined in this manner can then be provided to the laser device 10, by means of which the control device 18 can, for example, control the laser 12 and the beam deflection device 22 to change the refractive index. For the laser-induced refractive index change, a numerical aperture between 0.15 and 0.35, in particular between 0.2 and 0.3, a pulse length between 10 femtoseconds and 90 femtoseconds, in particular between 30 femtoseconds and 75 femtoseconds, an energy between 5 nanojoules and 95 nanojoules, in particular between 20 nanojoules and 80 nanojoules, a wavelength between 300 nanometers and 1500 nanometers, in particular between 900 nanometers and 1100 nanometers, and a repetition rate between 100 kHz and 100 MHz, in particular between 5 MHz and 75 MHz, can preferably be provided in the control data for controlling the laser device 10. In addition, a pulse distance along the scanning direction of between 1 nanometer and 10 micrometers, in particular between 10 nanometers and 1 micrometer, and a pulse path distance of corresponding adjacent laser pulse paths of between 10 nanometers and 50 micrometers, in particular between 50 nanometers and 5 micrometers, can preferably be provided by the beam deflection device 22.

[0047] In order to appropriately control laser device 10, for example, to achieve a refractive index change, it can be advantageous to vary only the energy and / or laser pulse distance within a corresponding irradiation parameter range, depending on the irradiation location in cornea 14 in the control data, wherein the values ​​are each selected from the further irradiation parameter range and kept constant. Thus, a suitable refractive index change can be achieved at every location on cornea 14 without generating cavitation bubbles.

[0048] The previously described embodiment is only one of many examples in which a property change, in particular a laser-induced refractive index change, can be produced in a biopolymer, in particular in the cornea 14. Alternatively or additionally, a crosslinking process can also be performed as a property change, wherein a property change model, for example, can be applied to this. Furthermore, the polymer structure can also be a plastic polymer, in particular for the production of intraocular lenses.

[0049] In summary, the examples show how the present invention provides optimal irradiation parameters for non-surgical approaches.

Claims

1. A computer program product comprising instructions for causing a control device (18) to execute a method for controlling a laser device (10) comprising a laser (12) to provide control data for non-destructive laser-induced property changes in a polymer structure (14), the method comprising: - determining (S10) a corresponding irradiation parameter range of a preset irradiation parameter of the laser device (10) by means of an irradiation model; - wherein a property change model is provided in the illumination model, wherein the induced property change of the polymer structure (14) is modeled as a function of the illumination parameters, wherein the property change model models a phase change of the polymer structure as a function of the illumination parameters in the laser-induced refractive index change of the polymer structure (14); - wherein a damage threshold model is provided in the irradiation model, wherein at least one threshold value of laser-induced damage of the polymer structure is modeled depending on the irradiation parameters; and - wherein the characteristic variation generated from the characteristic variation model is optimized while being limited by a threshold from the damage threshold model to determine the illumination parameter range; - providing (S12) control data of the laser device (10), including the determined range of irradiation parameters.

2. The computer program product according to claim 1, wherein the control data is provided for a laser induced refractive index change (LIRIC) of the polymer structure (14) and / or a cross-linking method of the polymer structure (14).

3. The computer program product of claim 1, wherein the control data is provided for a solid-state laser (12).

4. The computer program product of claim 1 , wherein for laser induced refractive index variation (LIRIC), the illumination parameter range is - Numerical aperture between 0.15 and 0.35; - Pulse length between 10fs and 90fs; - Energy between 5nJ and 95nJ; - Wavelength between 300nm and 1450nm; - and a repetition frequency between 100 kHz and 100 MHz; Provided as the control data. 5 . The computer program product according to claim 1 , wherein the control data are provided with a pulse distance in the scanning direction of between 1 nm and 10 μm. 6 . The computer program product according to claim 1 , wherein the control data include pulse path distances of respectively adjacent laser pulse paths of between 10 nm and 50 μm.

7. The computer program product of claim 1, wherein in determining the illumination parameter range, the illumination parameter is bounded from the threshold by a preset factor.

8. The computer program product of claim 1, wherein the control data provides for a change in a property of a biopolymer.

9. The computer program product of claim 1, wherein the control data provides for a property change of a plastic polymer.

10. The computer program product according to claim 1, wherein the energy and / or laser pulse distance for producing a characteristic change in the polymer structure is provided by variably varying values ​​within a corresponding irradiation parameter range in the control data, wherein a further irradiation parameter remains constant within its irradiation parameter range.

11. The computer program product of claim 1 , the method further comprising: - controlling the laser device (10) by means of the control device (18) such that it emits pulsed laser pulses in a shot sequence in a preset pattern into the polymer structure (14), wherein the laser pulses are emitted for non-destructive refractive index variation of the polymer structure, wherein the numerical aperture is between 0.15 and 0.35, the pulse length is between 10 fs and 90 fs, the energy is between 5 nJ and 95 nJ, the wavelength is between 300 nm and 1500 nm, and the repetition rate is between 100 kHz and 100 MHz.

12. A laser device (10) comprising the control device (18) configured to carry out the method according to claim 1.

13. The laser device (10) according to claim 12, wherein the laser device (10) comprises a solid-state laser (12).

14. The laser device (10) according to claim 12, wherein the laser device (10) is adapted to emit laser pulses having a wavelength in the range between 300 nm and 1500 nm, a corresponding pulse duration between 10 fs and 90 fs, and a repetition frequency greater than 10 kHz.

15. The laser device (10) according to claim 12, wherein the control device (18): - comprising at least one storage device for at least temporarily storing at least one control data set, wherein the one or more control data sets comprise control data for positioning and / or focusing and / or for adjustment of illumination parameters of individual laser pulses; and - comprising at least one beam device (22) for beam guidance, and / or beam shaping, and / or beam deflection, and / or beam focusing of the laser beam (20) of the laser device (10).

16. A computer-readable medium having stored thereon the computer program product according to claim 1.

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