A composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects and its application

Abstract

The invention discloses a composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects, comprising the following components: glycerol, trehalose, 1,3-propylene glycol, sodium hyaluronate, octyldodecanol, polydimethylsiloxane, tetrahydromethylpyrimidine carboxylic acid, dipotassium glycyrrhizinate, cyclodextrin / Centella asiatica extract, bifid yeast fermentation product lysate / phenoxyethanol / sodium benzoate, butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea extract / Glycyrrhiza glabra extract / Matricaria flower extract / Rosemary leaf extract, water / butylene glycol / Tremella polysaccharide, isopentyl glycol / parahydroxyacetophenone / 1,2-hexanediol; and also comprising glycerol / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate and butylene glycol / water / Perilla leaf extract. The essence prepared by the composition has the effects of increasing skin moisture content, reducing the length of forehead wrinkles and crow's feet, and reducing the skin firmness R0 value.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, and in particular to a composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects and application thereof. Background Art

[0002] Sensitive skin refers to a skin condition that is easily allergic and highly intolerant. Under external stimulation and environmental changes, the skin is prone to redness, swelling or stinging, and is prone to rashes or acne. In addition, sensitive skin has poor water retention, is relatively tight and dry, and easily leaves acne marks after inflammation fades. Studies have found that among sensitive skin, more than 70% of women with sensitive skin have weak or mild skin sensitivity, and nearly 30% of women with sensitive skin have sensitive symptoms such as redness, swelling, and inflammation.

[0003] Therefore, for people with sensitive skin, developing a skin care product that has moisturizing, anti-wrinkle and firming effects has very good application prospects. Summary of the invention

[0004] In view of the deficiencies of the prior art, the object of the present invention is to provide a composition suitable for sensitive skin and having moisturizing, anti-wrinkle and firming effects and its application.

[0005] The objective of the present invention is achieved through the following technical solutions:

[0006] In a first aspect, the present invention provides a composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects, comprising the following components in parts by weight: 1 to 6 parts of glycerol, 0.1 to 2 parts of trehalose, 2 to 5 parts of 1,3-propylene glycol, 0.005 to 0.015 parts of sodium hyaluronate, 0.1 to 1 parts of octyldodecanol, 0.5-2 parts of polydimethylsiloxane, 0.1-0.2 parts of tetrahydromethylpyrimidine carboxylic acid, 0.1-0.2 parts of dipotassium glycyrrhizinate, 0.1-0.3 parts of cyclodextrin / Centella asiatica extract, 5-10 parts of bifida fermentation product lysate / phenoxyethanol / sodium benzoate, 0.5-2 parts of butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria chamomilla extract / Rosemary leaf extract, 2-5 parts of water / butylene glycol / Tremella polysaccharide, 1-3 parts of isopentyl glycol / p-hydroxyacetophenone / 1,2-hexanediol.

[0007] As a preferred embodiment, the composition includes the following components in parts by weight: 3 parts of glycerin, 0.5 parts of trehalose, 3 parts of 1,3-propylene glycol, 0.01 parts of sodium hyaluronate, 0.4 parts of octyldodecanol, 1 part of polydimethylsiloxane, 0.1 parts of tetrahydromethylpyrimidine carboxylic acid, 0.1 parts of dipotassium glycyrrhizinate, 0.1 parts of cyclodextrin / Centella asiatica extract, 8 parts of bifida fermentation product lysate / phenoxyethanol / sodium benzoate, 1 part of butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria chamomilla extract / Rosemary leaf extract, 3 parts of water / butylene glycol / Tremella polysaccharide, and 2.5 parts of isopentyl glycol / p-hydroxyacetophenone / 1,2-hexanediol.

[0008] As a preferred embodiment, in the cyclodextrin / Centella asiatica extract, the mass proportion of the Centella asiatica extract is 15.5%.

[0009] As a preferred embodiment, in the butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria flower extract / Rosemary leaf extract, the mass ratio of Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria flower extract / Rosemary leaf extract is 5:2:2:1:1:0.5:0.5.

[0010] As a preferred embodiment, in the bifid yeast fermentation product lysate / phenoxyethanol / sodium benzoate, the mass proportion of the bifid yeast fermentation product lysate is 98.75%.

[0011] As a preferred embodiment, in the water / butylene glycol / tremella polysaccharide, the mass proportion of tremella polysaccharide is 0.2%.

[0012] As a preferred embodiment, the composition further comprises 1 to 3 parts of glycerin / water / soapwort leaf / root extract / potassium sorbate / sodium benzoate and 3 to 6 parts of butylene glycol / water / perilla leaf extract. The addition of soapwort leaf / root extract and perilla leaf extract further enhances the anti-wrinkle and firming effects of the composition.

[0013] As a preferred embodiment, the composition further comprises 2 parts of glycerin / water / soapwort leaf / root extract / potassium sorbate / sodium benzoate and 5 parts of butylene glycol / water / perilla leaf extract.

[0014] In a second aspect, the present invention provides a composition suitable for sensitive skin and having moisturizing, anti-wrinkle and firming effects, and its use in the preparation of cosmetics.

[0015] As a preferred embodiment, the dosage form of the cosmetic is any one of a cream, lotion, water solution, essence, mask, gel, base makeup, spray and cleansing product.

[0016] In a third aspect, the present invention provides an essence with moisturizing, anti-wrinkle and firming effects suitable for sensitive skin, including the aforementioned composition with moisturizing, anti-wrinkle and firming effects.

[0017] As a preferred embodiment, the essence further comprises the following components: at least one of a solvent, a chelating agent, a thickener, an emulsifier, a pH regulator, a solubilizing agent, and a fragrance.

[0018] As a preferred embodiment, the solvent is water;

[0019] The chelating agent is disodium EDTA;

[0020] The thickener is selected from at least one of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, xanthan gum, and ammonium acryloyldimethyltaurate / VP copolymer;

[0021] The emulsifier is PEG-20 methyl glucose sesquistearate;

[0022] The pH regulator is tromethamine;

[0023] The solubilizing agent is PPG-26-butanol polyether-26 / PEG-40 hydrogenated castor oil / water;

[0024] The fragrance is castor oil / North African cedar bark oil.

[0025] As a preferred embodiment, the essence further comprises the following components in parts by weight:

[0026] 50-90 parts of water, 0.01-0.05 parts of disodium EDTA, 0.05-0.2 parts of acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, 0.03-0.1 parts of xanthan gum, 0.3-0.7 parts of ammonium acryloyldimethyltaurate / VP copolymer, 0.3-0.5 parts of PEG-20 methyl glucose sesquistearate, 0.1-0.2 parts of tromethamine, 0.1-0.2 parts of PPG-26-butanol polyether-26 / PEG-40 hydrogenated castor oil / water, 0.1-0.2 parts of castor oil / North African cedar bark oil.

[0027] In a fourth aspect, the present invention provides a method for preparing an essence having moisturizing, anti-wrinkle and firming effects suitable for sensitive skin, comprising the following steps:

[0028] S1. Mix the solvent, chelating agent, thickener, glycerin, trehalose, 1,3-propylene glycol and sodium hyaluronate, and stir evenly to obtain phase A;

[0029] S2, mixing the emulsifier, octyldodecanol, polydimethylsiloxane and solubilizer, and stirring evenly to obtain phase B;

[0030] S3, dissolving the pH regulator in water to form phase C;

[0031] S4, dissolving dipotassium glycyrrhizinate, cyclodextrin / Centella asiatica extract and ectoine with a solvent to form a D phase;

[0032] S5. Mix bifid yeast fermentation product lysate / phenoxyethanol / sodium benzoate, butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Camellia oleifera extract / Glycyrrhiza glabra extract / Matricaria chamomilla flower extract / Rosemary leaf extract, water / butylene glycol / Tremella fuciformis polysaccharide, glycerin / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate, butylene glycol / water / Perilla frutescens leaf extract, isopentyl glycol / p-hydroxyacetophenone / 1,2-hexanediol and fragrance, and stir well to obtain phase E;

[0033] S6. Add phase B, phase C, phase D and phase E to phase A in sequence, stir, cool and defoam to obtain the moisturizing and anti-wrinkle essence.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] The present invention adopts a combination of bifid yeast fermentation product lysate, Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea extract, Glycyrrhiza glabra extract, Chamomile flower extract, Rosemary leaf extract, Tremella fuciformis polysaccharide, and other effective ingredients to prepare a composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects. Furthermore, by adding soapwort leaf extract and perilla extract, they produce a synergistic effect with the aforementioned bifid yeast fermentation product lysate, Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea extract, Glycyrrhiza glabra extract, Chamomile flower extract, Rosemary leaf extract, and Tremella polysaccharide, further enhancing the anti-wrinkle and firming effects, and improving the length of forehead wrinkles by as much as 9.07% (after 2 weeks of use) and 7.56% (after 4 weeks of use), the length of crow's feet by as much as 12.19% (after 2 weeks of use) and 13.99% (after 4 weeks of use), and the skin firmness R0 value by as much as 13.57% (after 2 weeks of use) and 18.96% (after 4 weeks of use), all of which are statistically significantly different from the baseline values ​​(P value < 0.01). BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments made with reference to the following drawings:

[0037] Figure 1The results of skin moisture content measured by the moisturizing and anti-wrinkle essence prepared in Example 4; the * in the figure indicates that there is a statistical difference compared with the basic value, P value <0.001 is marked as "***", 0.001≤P value <0.01 is marked as "**", and 0.01≤P value <0.05 is marked as "*";

[0038] Figure 2 The results of forehead wrinkle length measured by the moisturizing anti-wrinkle essence prepared in Example 4; the * in the figure indicates that there is a statistical difference compared with the basic value, P value <0.001 is marked as "***", 0.001≤P value <0.01 is marked as "**", and 0.01≤P value <0.05 is marked as "*";

[0039] Figure 3 The results of crow's feet length measured by the moisturizing anti-wrinkle essence prepared in Example 4; the * in the figure indicates that there is a statistical difference compared with the basic value, P value <0.001 is marked as "***", 0.001≤P value <0.01 is marked as "**", and 0.01≤P value <0.05 is marked as "*";

[0040] Figure 4 The results of the skin firmness R0 value measured by the moisturizing anti-wrinkle essence prepared in Example 4; the * in the figure indicates that there is a statistical difference compared with the basic value, P value <0.001 is marked as "***", 0.001≤P value <0.01 is marked as "**", and 0.01≤P value <0.05 is marked as "*";

[0041] Figure 5 The results of the skin elasticity R2 value measured using the moisturizing and anti-wrinkle essence prepared in Example 4; the * in the figure indicates a statistically significant difference compared with the baseline value, P value <0.001 is marked as "***", 0.001≤P value <0.01 is marked as "**", and 0.01≤P value <0.05 is marked as "*". DETAILED DESCRIPTION

[0042] The present invention is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the present invention, but are not intended to limit the present invention in any form. It should be noted that, for those of ordinary skill in the art, several variations and improvements may be made without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0043] The words "preferred", "preferably", "more preferably", etc. in the present invention refer to embodiments of the present invention that can provide certain beneficial effects in certain circumstances. However, other embodiments may also be preferred under the same circumstances or other circumstances. In addition, the description of one or more preferred embodiments does not imply that other embodiments are not applicable, nor is it intended to exclude other embodiments from the scope of the present invention.

[0044] It should be understood that, except in any operating examples, or otherwise indicated, all numbers representing the amount of ingredients used in the specification and claims should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise indicated, the numerical parameters set forth in the following specification and the appended claims are approximate values ​​that vary according to the desired performance to be obtained by the present invention. At least, it is not intended to limit the application of the doctrine of equivalents to the scope of the claims, and each numerical parameter should at least be interpreted according to the number of reported significant figures and by applying ordinary rounding techniques.

[0045] Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values ​​set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

[0046] In the following examples, the butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum

[0047] The mass ratio of the constituent raw materials: POLYGONUM CUSPIDATUM root extract / SCUTELLARIA BAICALENSIS root extract / CAMELLIA SINENSIS leaf extract / GLYCYRRHIZA GLABRA extract / CHAMOMILLA RECUTITA flower extract / ROSMARINUS OFFICINALIS leaf extract is 50:38:5:2:2:1:1:0.5:0.5.

[0048] The mass ratio of the constituent raw materials of the bifid yeast fermentation product lysate / phenoxyethanol / sodium benzoate is: 98.75:1:0.25.

[0049] The mass ratio of the various constituent raw materials of the cyclodextrin / Centella asiatica extract is 84.5:15.5.

[0050] The mass ratio of the constituent raw materials of the PPG-26-butanol polyether-26 / PEG-40 hydrogenated castor oil / water is 54:36:10.

[0051] The mass ratio of the various constituent raw materials of the castor (RICINUS COMMUNIS) oil / North African cedar (CEDRUS ATLANTICA) bark oil is 63:37.

[0052] The mass ratio of the constituent raw materials of glycerin / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate is: 48.8:48.8:2:0.2:0.2.

[0053] The mass ratio of each component raw material of the butylene glycol / water / perilla (PERILLA OCYMOIDES) leaf extract is: 49.6:49.6:0.8.

[0054] The mass ratio of the constituent raw materials of water / butylene glycol / tremella fuciformis polysaccharide is 59.8:40:0.2.

[0055] The mass ratio of the various constituent raw materials of the PEG-20 methyl glucose sesquistearate / tocopherol (vitamin E) is: 99.975:0.025.

[0056] The mass ratio of the constituent raw materials of isoprene diol / p-hydroxyacetophenone / 1,2-hexanediol is 50:25:25.

[0057] Example 1

[0058] This embodiment provides a moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, and the composition of each raw material is shown in Table 1. The preparation steps of the moisturizing and anti-wrinkle essence are as follows:

[0059] 1. Clean and disinfect the emulsification pot before manufacturing.

[0060] 2. Add disodium EDTA, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and part of water into an emulsifying pot at room temperature, stir at 30 rpm for 30 minutes until uniform, then add glycerol and trehalose in sequence and stir evenly;

[0061] 3. Add 1,3-propylene glycol, xanthan gum and sodium hyaluronate to the pre-dispersion container and disperse them for 30 minutes to make them completely dispersed. Put the resulting dispersion into the emulsifier and stir evenly;

[0062] 4. Add ammonium acryloyldimethyltaurate / VP copolymer into an emulsifying pot, then heat to 75-80°C, homogenize at 4500rpm for 3 minutes, stir at 30rpm for 10 minutes until dissolved evenly, and keep warm at 80°C for 30 minutes to obtain a phase A mixture;

[0063] 5. Add PEG-20 methyl glucose sesquistearate / tocopherol, octyldodecanol, dimethicone, PPG-26-buteth-26 / PEG-40 hydrogenated castor oil / water into the oil phase pot, heat to 70-75°C, stir at 30 rpm for 10 minutes until uniform, to obtain phase B;

[0064] 6. Add the stirred phase B from the oil phase pot to the emulsification pot treated in step 4, homogenize at 4200rpm for 3-5 minutes, stir at 40rpm for 15 minutes, and emulsify evenly under vacuum -0.03MPa;

[0065] 7. Pre-dissolve tromethamine with water to obtain phase C; pre-dissolve tetrahydromethylpyrimidine carboxylic acid, dipotassium glycyrrhizinate, and cyclodextrin / Centella asiatica extract with water to obtain phase D; mix bifida fermentation product lysate / phenoxyethanol / sodium benzoate, butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria chamomilla extract / Rosemary leaf extract, castor oil / Cedrus deodar bark oil, water / butylene glycol / Tremella fuciformis polysaccharide, isopentyl glycol / parahydroxyacetophenone / 1,2-hexanediol to obtain phase E;

[0066] 8. After the emulsification is uniform in step 6, cool the emulsification pot to 60-65°C, add the pre-dissolved phase C into the emulsification pot, and stir at 40 rpm for 15 minutes until the mixture is uniformly stirred;

[0067] 9. Cool down to 38-40°C, add phase E and pre-dissolved phase D in sequence, homogenize at 2500rpm for 1 minute, stir at 30rpm for 15 minutes, and stir evenly under vacuum at -0.03MPa;

[0068] 10. Maintain stirring at 30 rpm, cool to 30°C under vacuum -0.07 MPa to defoam;

[0069] 11. After defoaming is completed, the essence is packed into a sterilized barrel after confirmation by quality control, stored and inspected for more than 2 days, and the essence is obtained if it passes the inspection.

[0070] Example 2

[0071] This embodiment provides a moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, and the composition of each raw material is shown in Table 1. The preparation steps of the essence are basically the same as those in Example 1, except that: in step 7, glycerin / water / soapwort leaf / root extract / potassium sorbate / sodium benzoate, butylene glycol / water / perilla leaf extract are also added to the prepared phase E.

[0072] Example 3

[0073] This embodiment provides a moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, and the composition of each raw material is shown in Table 1. The preparation steps of the essence are the same as those of Example 2.

[0074] Example 4

[0075] This embodiment provides a moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, and the composition of each raw material is shown in Table 1. The preparation steps of the essence are the same as those of Example 2.

[0076] Example 5

[0077] This embodiment provides a moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, and the composition of each raw material is shown in Table 1. The preparation steps of the essence are basically the same as those in Example 1, except that: in step 7, glycerin / water / soapwort leaf / root extract / potassium sorbate / sodium benzoate are also added to the prepared phase E.

[0078] Example 6

[0079] This embodiment provides a moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, and the composition of each raw material is shown in Table 1. The preparation steps of the essence are basically the same as those in Example 1, except that in step 7, butylene glycol / water / perilla leaf extract are also added to the prepared phase E.

[0080] Table 1

[0081]

[0082]

[0083] Comparative Example 1

[0084] This comparative example provides an essence, the raw material composition of which is shown in Table 2, and compared with Example 4, only the bifida fermentation product lysate / phenoxyethanol / sodium benzoate is not added. The preparation steps of the moisturizing anti-wrinkle essence are the same as those of Example 4.

[0085] Comparative Example 2

[0086] This comparative example provides an essence, the raw material composition of which is shown in Table 2, and compared with Example 4, only butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Tea leaf extract / Glycyrrhiza glabra extract / Matricaria chamomilla extract / Rosmarinus officinalis leaf extract are not added. The preparation steps of the moisturizing anti-wrinkle essence are the same as those of Example 4.

[0087] Comparative Example 3

[0088] This comparative example provides an essence, the composition of each raw material of which is shown in Table 2. Compared with Example 4, only water / butylene glycol / tremella polysaccharide is not added. The preparation steps of the moisturizing and anti-wrinkle essence are the same as those of Example 4.

[0089] Table 2

[0090]

[0091]

[0092] Efficacy verification:

[0093] The essences prepared in the above Examples 1-6 and Comparative Examples 1-3 were tested for moisturizing, anti-wrinkle and firming effects. Each experimental data is the average value of multiple test subjects (n≥5), as follows:

[0094] 1) Skin moisture content test

[0095] The subjects were healthy subjects aged 18-65 years. They washed their faces with a standard facial cleanser, patted dry with a paper towel, sat in a temperature-controlled room for 30 minutes, and then applied the test product to their faces and waited for it to be absorbed. Before applying the test product (0 hours), 1 hour and 8 hours after applying the test product, the non-invasive skin test instrument was used to CM825 (Courage-Khazaka) measures the moisture content of the stratum corneum of facial skin. All measurements are performed in a constant temperature and humidity room with a temperature of 20-22°C and a relative humidity of 40-60%.

[0096] The test results obtained by using the moisturizing and anti-wrinkle essence prepared in Examples 1-3 as the test sample are shown in Table 3.

[0097] Table 3

[0098]

[0099]

[0100] Improvement rate = (measured value after applying the test product - basic value) / basic value × 100%, wherein the basic value is the measured value before applying the test product (0 hours).

[0101] From the results in Table 3, it can be seen that the moisturizing and anti-wrinkle essences prepared in Examples 1-6 can effectively improve the moisture content of the skin, especially the moisturizing and anti-wrinkle essence prepared in Example 4 has an improvement rate of 31.08% and 22.27% after 1 hour and 8 hours, respectively, which is significantly different from the basic value (such as Figure 1 As shown, P value < 0.01).

[0102] 2) Anti-wrinkle, skin elasticity and firmness test

[0103] Healthy subjects aged 35-55 years old with sensitive skin (stinging score ≥ 3 points) determined by the lactic acid sting test were selected as the test subjects. After cleansing, the subjects took an appropriate amount of the test product on the palm of their hands, gently and evenly applied it to the face, and massaged until absorbed. Use it twice a day, once in the morning and once in the evening. During the test period, the subjects did not change other living, eating and skin care habits, and completely used the provided test products to replace their own essence products during the test period.

[0104] The subjects were tested before use (D0), after 2 weeks of use (D14), and after 4 weeks of use (D28). At the test site, the subjects washed their faces with a standard facial cleanser, patted them dry with a paper towel, and sat in a temperature-controlled room for 30 minutes. The texture image analysis system PRIMOS CR (Canfield) was used to photograph wrinkles and obtain the results of forehead wrinkle length and crow's feet length. Dual MPA 580 (Courage+Khazaka) measures the skin's elasticity R0 value and firmness R2 value. The measurement parameters are set as: On-Time: 1.0s, Off-Time: 1.0s, Pressure: 450mbar, Repetition: 10. The R0 value reflects the passive feedback of the skin to external forces. The smaller the R0 value, the firmer the skin. The R2 value is the total elasticity. The closer the R2 value is to 1 (100%), the more elastic it is.

[0105] The length test results of forehead wrinkles and crow's feet obtained by using the moisturizing anti-wrinkle essence prepared in Example 1 as the test sample are shown as a typical example. Figure 2 and Figure 3 As shown, the improvement rates of forehead wrinkles length and crow's feet length obtained by using the moisturizing anti-wrinkle essences prepared in Examples 1-3 and Comparative Examples 1-4 as test samples are shown in Table 4.

[0106] Table 4

[0107]

[0108]

[0109] Improvement rate = (wrinkle length value after using the test product - basic value) / basic value × 100%, wherein the basic value is the wrinkle length value before using the test product (D0 day).

[0110] From Table 4 and Figure 2 , Figure 3 The results show that the moisturizing anti-wrinkle essences prepared in Examples 2-4 have very obvious wrinkle removal effects, especially the moisturizing anti-wrinkle essence prepared in Example 4 has a 9.07% and 7.56% decrease in the improvement rate of forehead wrinkles length after 2 weeks and 4 weeks, respectively, which is significantly different from the basic value (such as Figure 2 As shown, P value <0.01); the improvement rate of crow's feet length of the moisturizing anti-wrinkle essence prepared in Example 4 decreased by 12.19% and 13.99% after 2 weeks and 4 weeks, respectively, which was significantly different from the baseline value (as shown in Figure 3 As shown, P value <0.01). Moreover, the improvement rate result of Example 4 is significantly improved compared with Comparative Examples 1-3 and Examples 1, 5, and 6, indicating that in the moisturizing anti-wrinkle essence of the present invention, the lysate of the fermentation product of bifid yeast and the Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Tea leaf extract / Glycyrrhiza glabra extract / Matricaria flower extract / Rosemary leaf extract, Tremella fuciformis polysaccharide, glycerin / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate and butylene glycol / water / Perilla frutescens leaf extract have obvious synergistic effects, thereby achieving a very good wrinkle removal effect.

[0111] The skin firmness R0 value and skin elasticity R2 value test results obtained by using the moisturizing anti-wrinkle essence prepared in Example 4 as the test sample are shown as typical examples. Figure 4 and Figure 5 As shown, the improvement rates of skin firmness R0 value and skin elasticity R2 value obtained by using the moisturizing anti-wrinkle essences prepared in Examples 1-6 and Comparative Examples 1-3 as test samples are shown in Table 5.

[0112] Table 5

[0113]

[0114]

[0115] From Table 5 and Figure 4 The results show that the moisturizing anti-wrinkle essences prepared in Examples 2-4 have a very obvious effect of improving skin firmness. In particular, the improvement rate of the R0 value of the moisturizing anti-wrinkle essence prepared in Example 4 decreased by 13.57% and 18.96% after 2 weeks and 4 weeks, respectively, which is significantly different from the basic value (such as Figure 4As shown, P value <0.01). Moreover, the improvement rate of R0 value of Example 4 is significantly improved compared with Comparative Examples 1-4 and Examples 1, 5, and 6, indicating that in the moisturizing anti-wrinkle essence of the present invention, the lysate of the fermentation product of bifid yeast and the Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Tea leaf extract / Glycyrrhiza glabra extract / Matricaria flower extract / Rosemary leaf extract, Tremella fuciformis polysaccharide, glycerin / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate and butylene glycol / water / Perilla frutescens leaf extract have obvious synergistic effect, thereby obtaining a very good effect of improving skin firmness.

[0116] From Table 5 and Figure 5 The results show that the essences prepared in Examples 1-6 and Comparative Examples 1-3 all have a certain effect of improving skin elasticity, but the difference in the effects of each example and comparative example is not obvious. From the results of Examples 1, 4-6 and Comparative Examples 1-3, it can be seen that the lysate of the fermentation product of bifid yeast and the Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Tea extract / Glycyrrhiza glabra extract / Matricaria flower extract / Rosemary leaf extract, Tremella fuciformis polysaccharide, glycerin / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate and butylene glycol / water / Perilla leaf extract do not have a synergistic effect of improving skin elasticity. The moisturizing and anti-wrinkle essence prepared in Example 4 has an improvement rate of 2.68% and 5.47% in the R2 value after 2 weeks and 4 weeks, respectively, which is different from the basic value (such as Figure 5 As shown, 0.01≤P value<0.05 after 4 weeks of use).

[0117] In addition, after using each test sample, each subject believed that each test sample had no itching, tingling, heating, redness, edema, etc. during use, indicating that the essence prepared by the present invention is suitable for sensitive skin.

[0118] The present invention has many specific application paths, and the above is only a preferred embodiment of the present invention. It should be pointed out that the above embodiments are only used to illustrate the present invention, and are not used to limit the protection scope of the present invention. For those of ordinary skill in the art, several improvements can be made without departing from the principle of the present invention, and these improvements should also be regarded as the protection scope of the present invention.

Claims

1. A composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects, characterized in that: The invention comprises the following components in parts by weight: 1-6 parts of glycerin, 0.1-2 parts of trehalose, 2-5 parts of 1,3-propylene glycol, 0.005-0.015 parts of sodium hyaluronate, 0.1-1 parts of octyldodecanol, 0.5-2 parts of polydimethylsiloxane, 0.1-0.2 parts of tetrahydromethylpyrimidine carboxylic acid, 0.1-0.2 parts of dipotassium glycyrrhizinate, 0.1-0.3 parts of cyclodextrin / Centella asiatica extract, 5-10 parts of bifida yeast fermentation product lysate / phenoxyethanol / sodium benzoate, 0.5-2 parts of butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria chamomilla extract / Rosemary leaf extract, 2-5 parts of water / butylene glycol / Tremella fuciformis polysaccharide, 1-3 parts of isopentyl glycol / p-hydroxyacetophenone / 1,2-hexanediol; The composition further comprises: 1 to 3 parts of glycerin / water / soapwort leaf / root extract / potassium sorbate / sodium benzoate and 3 to 6 parts of butylene glycol / water / perilla leaf extract.

2. The composition suitable for sensitive skin with moisturizing, anti-wrinkle and firming effects according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 3 parts of glycerin, 0.5 parts of trehalose, 3 parts of 1,3-propylene glycol, 0.01 parts of sodium hyaluronate, 0.4 parts of octyldodecanol, 1 part of polydimethylsiloxane, 0.1 parts of tetrahydromethylpyrimidine carboxylic acid, 0.1 parts of dipotassium glycyrrhizinate, 0.1 parts of cyclodextrin / Centella asiatica extract, 8 parts of bifida fermentation product lysate / phenoxyethanol / sodium benzoate, 1 part of butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / tea leaf extract / Glycyrrhiza glabra extract / Matricaria chamomilla extract / Rosemary leaf extract, 3 parts of water / butylene glycol / Tremella polysaccharide, and 2.5 parts of isopentyl glycol / p-hydroxyacetophenone / 1,2-hexanediol.

3. The composition with moisturizing, anti-wrinkle and firming effects suitable for sensitive skin according to claim 2, characterized in that: The weight proportion of the glycerin / water / soapwort leaf / root extract / potassium sorbate / sodium benzoate is 2 parts, and the weight proportion of butylene glycol / water / perilla leaf extract is 5 parts.

4. Use of the composition having moisturizing, anti-wrinkle and firming effects suitable for sensitive skin according to any one of claims 1 to 3 in the preparation of cosmetics.

5. The use according to claim 4, characterized in that: The dosage form of the cosmetic is any one of cream, lotion, water, essence and gel.

6. The use according to claim 4, characterized in that: The cosmetic is any one of a facial mask, a base makeup, a spray and a facial cleanser.

7. A moisturizing, anti-wrinkle and firming essence suitable for sensitive skin, characterized in that: The invention comprises the composition having moisturizing, anti-wrinkle and firming effects as described in any one of claims 1 to 3.

8. The essence with moisturizing, anti-wrinkle and firming effects suitable for sensitive skin according to claim 7, characterized in that: The essence also includes the following components: at least one of a solvent, a chelating agent, a thickener, an emulsifier, a pH regulator, a solubilizing agent, and a fragrance.

9. The moisturizing, anti-wrinkle and firming essence suitable for sensitive skin according to claim 8, characterized in that: The solvent is water; The chelating agent is disodium EDTA; The thickener is selected from at least one of acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer, xanthan gum, and ammonium acryloyldimethyltaurate / VP copolymer; The emulsifier is PEG-20 methyl glucose sesquistearate; The pH regulator is tromethamine; The solubilizing agent is PPG-26-butanol polyether-26 / PEG-40 hydrogenated castor oil / water; The fragrance is castor oil / North African cedar bark oil.

10. A method for preparing the essence with moisturizing, anti-wrinkle and firming effects suitable for sensitive skin according to any one of claims 7 to 9, characterized in that: The following steps are involved: S1. Mix the solvent, chelating agent, thickener, glycerin, trehalose, 1,3-propylene glycol and sodium hyaluronate, and stir evenly to obtain phase A; S2, mixing the emulsifier, octyldodecanol, polydimethylsiloxane and solubilizer, and stirring evenly to obtain phase B; S3, dissolving the pH regulator in water to form phase C; S4, dissolving dipotassium glycyrrhizinate, cyclodextrin / Centella asiatica extract and ectoine with a solvent to form a D phase; S5. Mix bifid yeast fermentation product lysate / phenoxyethanol / sodium benzoate, butylene glycol / water / Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Camellia oleifera extract / Glycyrrhiza glabra extract / Matricaria chamomilla flower extract / Rosemary leaf extract, water / butylene glycol / Tremella fuciformis polysaccharide, glycerin / water / Saponaria officinalis leaf / root extract / potassium sorbate / sodium benzoate, butylene glycol / water / Perilla frutescens leaf extract, isopentyl glycol / p-hydroxyacetophenone / 1,2-hexanediol and fragrance, and stir well to obtain phase E; S6. Add phase B, phase C, phase D and phase E to phase A in sequence, stir, cool and defoam to obtain the product.

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