Anti-aging composition, anti-aging cosmetics and anti-aging essence

Abstract

The present application relates to the field of cosmetic technology, more specifically, it relates to an anti-aging composition, anti-aging cosmetics and anti-aging essence.An anti-aging composition is composed of hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides, and the weight ratio of the hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides is 1:(0.20-0.25):(6.5-7.0).The anti-aging composition of the present application, using hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides to be compounded, can effectively resist ultraviolet light, has good antioxidant and hydrating properties, can be applied to prepare cosmetics, improve skin wrinkles.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and more specifically, to an anti-aging composition, anti-aging cosmetics and anti-aging essence. Background Art

[0002] Skin aging is a process in which the body's functions develop naturally, either quickly or slowly, due to factors such as the gradual slowing of cell metabolism, the gradual loss of collagen, environmental pollution, and excessive ultraviolet radiation. The main manifestations on the skin include wrinkles and sagging skin.

[0003] Currently, vitamin antioxidants are added to cosmetics to smooth wrinkles and improve skin texture because they contain antioxidant ingredients that can remove free radicals and promote skin metabolism.

[0004] However, due to the poor stability of vitamin antioxidants, they are easily oxidized in cosmetics and lose their antioxidant components, so there is a problem that the anti-aging effect of cosmetics is not obvious. Summary of the invention

[0005] In order to improve the anti-aging effect of cosmetics, the present application provides an anti-aging composition, anti-aging cosmetics and anti-aging essence.

[0006] In the first aspect, the present application provides an anti-aging composition, which adopts the following technical solution:

[0007] An anti-aging composition is composed of a mixture of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide, wherein the weight ratio of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide is 1:(0.20-0.25):(6.5-7.0).

[0008] Hydroxypinacolone retinoic acid ester is a vitamin A compound formed by the dehydration condensation of retinoic acid and pinacol. It has low irritation, high stability, small molecular weight, and is easily absorbed through the skin. It can directly act on the skin, scavenge skin free radicals, promote collagen production, and improve skin fine lines and wrinkles.

[0009] Buddleja extract contains glycyrrhizic acid and other ingredients, which have plant biological activity and can effectively remove active oxygen and free radicals produced by ultraviolet, blue light and infrared radiation, protect the skin from oxidative damage, and maintain the skin's redox balance.

[0010] By adopting the above technical scheme, hydroxypinacolone retinoic acid ester, Buddleja flower extract and oligopeptide are compounded. On the one hand, since Buddleja flower extract has a protective effect on the full spectrum, including ultraviolet light, blue light and infrared wavelengths; therefore, Buddleja flower extract can improve the effect of light on hydroxypinacolone retinoic acid ester, which is beneficial to improve the stability of hydroxypinacolone retinoic acid ester in the composition, thereby improving the effect of the composition in removing skin free radicals, promoting collagen production, and improving skin fine lines and wrinkles. On the other hand, oligopeptides, hydroxypinacolone retinoic acid ester and Buddleja flower extract work together to remove free radicals, reduce the concentration of inflammatory factors caused by oxidative stress, and promote the synthesis of collagen, elastin and hyaluronic acid, which is beneficial to maintain the redox balance of the skin, increase the water content and moisturizing ability of the skin stratum corneum, increase skin elasticity, and further improve the effect of skin fine lines and wrinkles.

[0011] At the same time, the composition obtained by compounding small molecule hydroxypinacolone retinoic acid ester, oligopeptide and Buddleja buddleja extract has good transdermal absorption ability, which is beneficial for the composition to act directly on the skin and improve the effect of the composition on improving skin fine lines and wrinkles.

[0012] Preferably, the hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide are mixed in a weight ratio of 1:0.22:6.8.

[0013] By adopting the above technical scheme, the compounding ratio of hydroxypinacolone retinoic acid ester, buddleja flower extract and oligopeptides is further optimized, and the resulting composition has a high transdermal absorption capacity and has high stability, antioxidant and anti-wrinkle properties.

[0014] Preferably, the specification of the Buddleja buddleja extract is 15:1 or 20:1.

[0015] By adopting the above technical scheme, the specification of 15:1 or 20:1 means that 1kg of Buddleja buddleja extract is extracted from 15kg or 20kg of Buddleja buddleja extract, and the specifications of Buddleja buddleja extract are different, and the concentration of the obtained Buddleja buddleja extract is different. By compounding the Buddleja buddleja extract of the above specifications with hydroxypinacolone retinoic acid ester and oligopeptide, not only the stability of hydroxypinacolone retinoic acid ester in the composition can be improved, which is beneficial for scavenging free radicals, but also the water content of the stratum corneum of the skin can be increased, the skin elasticity can be improved, and the effect of further improving the fine lines and wrinkles of the skin can be improved.

[0016] Preferably, the oligopeptide is one or more of oligopeptide-1, oligopeptide-3 and oligopeptide-5.

[0017] By adopting the above technical solution, oligopeptide-1, oligopeptide-3 and oligopeptide-5 are directly absorbed by the skin, promoting skin cell regeneration and proliferation, improving skin metabolism, and quickly replenishing collagen to the skin, increasing the water content of the stratum corneum of the skin, and improving skin elasticity. Therefore, adding the above oligopeptides to the composition can effectively improve the anti-wrinkle and moisturizing effect of the composition.

[0018] Preferably, the oligopeptide is composed of a mixture of oligopeptide-1, oligopeptide-3 and oligopeptide-5, and the weight ratio of oligopeptide-1, oligopeptide-3 and oligopeptide-5 is 1:(0.2-0.6):(0.4-0.8).

[0019] By adopting the above technical solution, the type and proportion of oligopeptides added to the composition are optimized, which is beneficial to increasing the transdermal absorption capacity of the obtained composition and further improving the anti-wrinkle and moisturizing effects of the composition.

[0020] In a second aspect, the present application provides an anti-aging cosmetic, which adopts the following technical solution:

[0021] An anti-aging cosmetic comprises the anti-aging composition and cosmetic accessories.

[0022] By adopting the above technical scheme, the cosmetics prepared by mixing the above anti-aging composition and cosmetic auxiliary materials have good stability, antioxidant, anti-wrinkle and moisturizing properties, and can effectively improve skin wrinkles.

[0023] Preferably, calculated as a percentage by weight of the cosmetic, the amount of the anti-aging composition added is 0.01-0.023%.

[0024] By adopting the above technical solution, the amount of the anti-aging composition added to the cosmetics is optimized, and the obtained cosmetics have relatively excellent stability, antioxidant, anti-wrinkle and moisturizing properties when the amount of the anti-aging composition is small. At the same time, the obtained cosmetics have mild use effects, are safe and non-irritating.

[0025] Preferably, the cosmetic is one of skin care lotion, essence, emulsion or cream.

[0026] By adopting the above technical scheme, the anti-aging composition of the present application can be prepared into different types of cosmetics according to actual needs, has strong applicability, and is conducive to large-scale production.

[0027] In a third aspect, the present application provides an anti-aging serum, which adopts the following technical solution:

[0028] An anti-aging essence, calculated by weight percentage, consists of the following components:

[0029] 0.01-0.023% of the above anti-aging composition;

[0030] Sodium oligomeric hyaluronate 0.5-1%;

[0031] Acetylated sodium hyaluronate 0.5-1%;

[0032] Butanediol 4-10%;

[0033] PEG-40 hydrogenated castor oil 0.02-0.03%;

[0034] Xanthan gum 0.1-0.2%;

[0035] Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.3-1%;

[0036] Aminomethyl propanol 0.02-0.05%;

[0037] p-Hydroxyacetophenone 0.01-0.1%;

[0038] Water is the balance.

[0039] By adopting the above technical solution, after the above anti-wrinkle composition is mixed with oligomeric sodium hyaluronate and acetylated sodium hyaluronate, the obtained essence not only has a good anti-wrinkle effect, but also has a good moisturizing effect.

[0040] In summary, this application has the following beneficial effects:

[0041] Since the present application adopts the compounding of hydroxypinacolone retinoic acid ester, buddleja flower extract and oligopeptide, it can effectively resist ultraviolet light, scavenge free radicals, replenish skin moisture and improve skin metabolism. Therefore, the obtained anti-wrinkle composition has good stability, antioxidant and transdermal absorption capacity, and can effectively improve skin wrinkles. DETAILED DESCRIPTION

[0042] The present application is further described in detail below in conjunction with embodiments.

[0043] Unless otherwise specified below, the raw materials or reagents used in the preparation examples, comparative preparation examples, embodiments and comparative examples of the present application are commercially available.

[0044] Performance Testing

[0045] The anti-aging compositions obtained in the preparation examples of the present application and the comparative preparation examples were subjected to hydroxyl radical scavenging rate detection and DPPH radical scavenging rate detection, and the detection methods are as follows:

[0046] 1. Hydroxyl free radical scavenging rate detection

[0047] (1) Reagent preparation

[0048] FeSO4·7H2O solution: accurately weigh 2.224g FeSO4·7H2O, dissolve it in 100mL deionized water, mix well, take 10mL, and make up to 100mL to prepare 8mmol / LFeSO4·7H2O solution.

[0049] H2O2 solution: Weigh 68 mg of 30% H2O2 solution, mix it evenly with 1 mL of deionized water, and make up to 100 mL to prepare a 6 mmol / L H2O2 solution.

[0050] Sodium salicylate solution: Weigh 0.3202 g of sodium salicylate, dissolve it in an appropriate amount of deionized water, and make up to 100 mL to prepare a 20 mmol / L sodium salicylate solution.

[0051] Anti-aging composition sample solution: Weigh 0.5 g of the anti-aging composition in each preparation example or comparative preparation example, dissolve it in an appropriate amount of deionized water, make up to 100 mL, and prepare an anti-aging composition sample mother solution with a mass concentration of 5 mg / mL. Then use the mother solution to prepare an anti-aging composition sample solution with a mass concentration of 0.5 mg / mL for use.

[0052] (2) Hydroxyl radical scavenging rate detection operation steps: According to the table below, FeSO4·7H2O solution, H2O2 solution, sodium salicylate solution and anti-aging composition sample solution were heated in a 37°C water bath for 1 h, and then appropriate amounts of reagents were added to a quartz cuvette. The absorbance was measured at a wavelength of 510 nm. Each experimental group was performed in parallel for 3 times.

[0053]

[0054] In the above table, A0 is the absorbance of the mixed solution when sodium salicylate is added but no anti-aging composition sample solution is added; A1 is the absorbance of the mixed solution when both the anti-aging composition sample solution and sodium salicylate are added; A2 is the absorbance of the mixed solution when the anti-aging composition sample solution is added but no sodium salicylate is added.

[0055] The calculation formula of hydroxyl radical scavenging rate is as follows:

[0056] Hydroxyl radical scavenging rate = [1-(A1-A2) / A0] × 100%.

[0057] 2. DPPH free radical scavenging rate detection

[0058] (1) Solution preparation

[0059] Preparation of DPPH solution: accurately weigh 3 mg of 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) powder and dissolve it in 60 mL of anhydrous ethanol. Ultrasonicate for 15 minutes and shake thoroughly to dissolve DPPH evenly to obtain DPPH solution. After the ultrasonication, take 1 mL of the solution and measure the absorbance at a wavelength of 519 nm. Add DPPH solution or anhydrous ethanol to make the absorbance between 1.2 and 1.3.

[0060] Anti-aging composition sample solution: Weigh 0.5 g of the anti-aging composition in each preparation example or comparative preparation example, dissolve it in an appropriate amount of deionized water, make up to 100 mL, and prepare an anti-aging composition sample mother solution with a mass concentration of 5 mg / mL. Then use the mother solution to prepare an anti-aging composition sample solution with a mass concentration of 0.5 mg / mL for use.

[0061] (2) Sample dosage test

[0062] Take 2 mL of the DPPH solution prepared in (1) into a colorimetric tube, add 100 μL of the anti-aging composition sample solution thereto, shake well, and observe its fading. Subsequently, add the anti-aging composition sample solution to the colorimetric tube in units of 20-30 μL each time until the color of the solution is basically faded. Record the total amount of the anti-aging composition sample solution added, X μL.

[0063] (3) DPPH free radical scavenging rate detection

[0064] Steps:

[0065] Measure the absorbance A0: Take 2 mL of the DPPH solution prepared in (1) into a test tube, add 1 mL of deionized water, shake well, let stand at 37°C for 30 min, and measure the absorbance A0 at a wavelength of 519 nm.

[0066] Measure the absorbance A1: Take 2 mL of the DPPH solution prepared in (1) into a test tube, add X μL of the anti-aging composition sample solution and (1000-X) μL of deionized water, shake well, let stand at 37°C for 30 minutes, and then measure the absorbance A1 at a wavelength of 519 nm.

[0067] The calculation formula of DPPH free radical scavenging rate is as follows:

[0068] DPPH free radical scavenging rate = [(A0-A1) / A0] × 100%.

[0069] Preparation example of anti-aging composition

[0070] Preparation Example 1

[0071] An anti-aging composition, the components and their weights are shown in the following table:

[0072]

[0073] The preparation method of the anti-aging composition is as follows: hydroxypinacolone retinoic acid ester, buddleja flower extract and oligopeptide are stirred and mixed to obtain the anti-aging composition.

[0074] In the preparation example of the present application, hydroxypinacolone retinoic acid ester, item number 0038, was purchased from Jinan Jinbang Environmental Protection Technology Co., Ltd.

[0075] Buddleja mongholica extract, extracted from Buddleja mongholica, specification is 20:1, customized by Lanzhou Waterless Biotechnology Co., Ltd.

[0076] The oligopeptide is composed of oligopeptide-1, oligopeptide-3 and oligopeptide-5 mixed in a weight ratio of 1:0.4:0.6.

[0077] Oligopeptide-1, model AS-01, purchased from Shaanxi Xiazhou Biotechnology Co., Ltd.

[0078] Oligopeptide-3, model number cx123456, was purchased from Shaanxi Chenxi Biotechnology Co., Ltd.

[0079] Oligopeptide-5, model number YS, was purchased from Chengdu Yunxi Chemical Co., Ltd.

[0080] Preparation Example 2-3

[0081] An anti-aging composition, which is different from Preparation Example 1 in that the components and their weights are shown in the following table:

[0082]

[0083] The anti-aging compositions obtained in the above-mentioned preparation examples 1-3 were subjected to hydroxyl radical scavenging rate detection and DPPH radical scavenging rate detection, and the test results are as follows:

[0084]

[0085] By analyzing the data in the above table, it can be seen that the anti-wrinkle composition obtained in Preparation Examples 1-3 has a hydroxyl radical scavenging rate of up to 88.03-93.35%, and a DPPH radical scavenging rate of up to 83.15-88.51%. This shows that the anti-aging composition obtained in Preparation Examples 1-3 of the present application has a good hydroxyl radical scavenging rate and DPPH free radical scavenging rate.

[0086] In particular, the hydroxyl radical scavenging rate and DPPH radical scavenging rate of the anti-wrinkle composition obtained in Preparation Example 1 were the highest. This indicates that in the total raw materials for preparing the anti-wrinkle composition, hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide are mixed in a weight ratio of 1:0.22:6.8, which can improve the antioxidant performance of the anti-wrinkle composition.

[0087] Preparation Example 4

[0088] An anti-aging composition, which is different from Preparation Example 1 in that the Buddleja mongholicus extract is extracted from Buddleja mongholicus, has a specification of 15:1, and is customized by Lanzhou Waterless Biotechnology Co., Ltd.

[0089] Preparation Example 5

[0090] An anti-aging composition, which is different from Preparation Example 1 in that the Buddleja mongholica extract is extracted from Buddleja mongholica, has a specification of 10:1, and is customized by Lanzhou Waterless Biotechnology Co., Ltd.

[0091] Preparation Example 6

[0092] An anti-aging composition, which is different from Preparation Example 1 in that the Buddleja mongholicus extract is extracted from Buddleja mongholicus, has a specification of 30:1, and is customized by Lanzhou Waterless Biotechnology Co., Ltd.

[0093] The anti-aging compositions obtained in the above-mentioned Preparation Examples 4-6 were subjected to hydroxyl radical scavenging rate detection and DPPH radical scavenging rate detection. The test results are as follows:

[0094]

[0095] According to the data analysis of the above table, the anti-wrinkle compositions obtained in Preparation Examples 1 and 4 have a hydroxyl radical scavenging rate of up to 91.02-93.35%, and a DPPH free radical scavenging rate of up to 86.12-88.51%. The anti-wrinkle compositions obtained in Preparation Examples 5 and 6 have a hydroxyl radical scavenging rate of up to 89.888-90.31%, and a DPPH free radical scavenging rate of up to 84.35-83.86%.

[0096] Comparing the test results of Preparation Examples 1 and 4 with those of Preparation Examples 5 and 6, it can be seen that the anti-wrinkle compositions obtained in Preparation Examples 1 and 4 have higher hydroxyl radical scavenging rates and DPPH radical scavenging rates. This shows that in the total raw materials for preparing the anti-wrinkle composition of the present application, the specification of the Buddleja monnieri extract is 15:1 or 20:1, which can improve the antioxidant capacity of the anti-wrinkle composition.

[0097] Preparation Example 7

[0098] An anti-aging composition, which is different from Preparation Example 1 in that the oligopeptide is composed of oligopeptide-1, oligopeptide-3 and oligopeptide-5 mixed in a weight ratio of 1:0.2:0.4.

[0099] Preparation Example 8

[0100] An anti-aging composition, which is different from Preparation Example 1 in that the oligopeptide is composed of oligopeptide-1, oligopeptide-3 and oligopeptide-5 mixed in a weight ratio of 1:0.6:0.8.

[0101] Preparation Example 9

[0102] An anti-aging composition, which is different from Preparation Example 1 in that the oligopeptide is oligopeptide-1.

[0103] Preparation Example 10

[0104] An anti-aging composition, which is different from Preparation Example 1 in that it is composed of a mixture of oligopeptide-1 and oligopeptide-3, and the weight ratio of oligopeptide-1 to oligopeptide-3 is 1:1.

[0105] The anti-aging compositions obtained in the above-mentioned Preparation Examples 7-10 were subjected to hydroxyl radical scavenging rate detection and DPPH radical scavenging rate detection, and the test results are as follows:

[0106]

[0107] According to the data analysis of the above table, the anti-wrinkle compositions obtained in Preparation Examples 1, 7, and 8 have a hydroxyl radical scavenging rate of up to 92.00-93.35%, and a DPPH radical scavenging rate of up to 86.88-88.51%. The anti-wrinkle compositions obtained in Preparation Examples 9 and 10 have a hydroxyl radical scavenging rate of up to 91.52-91.85%, and a DPPH radical scavenging rate of up to 86.52-76.75%.

[0108] Comparing the test results of Preparation Examples 1, 7, and 8 with those of Preparation Examples 9 and 10, it can be seen that the anti-wrinkle compositions obtained in Preparation Examples 1, 7, and 8 have higher hydroxyl radical scavenging rates and DPPH radical scavenging rates. This shows that in the total raw materials for preparing the anti-wrinkle composition of the present application, the oligopeptides are composed of oligopeptide-1, oligopeptide-3, and oligopeptide-5 mixed in a weight ratio of 1: (0.2-0.6): (0.4-0.8), which can improve the antioxidant capacity of the anti-wrinkle composition.

[0109] Comparative Preparation Example 1

[0110] An anti-aging composition, which is different from Preparation Example 1 in that an equal weight of retinol is used to replace hydroxypinacolone retinoic acid ester, wherein the model of retinol is TZCSW02730, which is purchased from Shaanxi Tianzhicheng Biotechnology Co., Ltd.

[0111] Comparative Preparation Example 2

[0112] An anti-aging composition, which is different from Preparation Example 1 in that an equal weight of troxerutin is used to replace the buddleja flos extract, wherein the troxerutin has a product number of ZX-HZP-0080 and is purchased from Xi'an Zhanxun Biotechnology Co., Ltd.

[0113] Comparative Preparation Example 3

[0114] An anti-aging composition, which is different from Preparation Example 1 in that an equal weight of hydroxypinacolone retinoic acid ester is used to replace the oligopeptide.

[0115] Comparative Preparation Example 4

[0116] An anti-aging composition, which is different from Preparation Example 1 in that an equal weight of retinol is used to replace hydroxypinacolone retinoic acid ester, and an equal weight of troxerutin is used to replace Buddleja monnieri extract.

[0117] Comparative Preparation Example 5

[0118] An anti-aging composition, which is different from Preparation Example 1 in that an equal weight of retinol is used to replace hydroxypinacolone retinoic acid ester, and an equal weight of hydroxypinacolone retinoic acid ester is used to replace oligopeptide.

[0119] Comparative Preparation Example 6

[0120] An anti-aging composition, which is different from Preparation Example 1 in that an equal weight of troxerutin is used to replace the buddleja flower extract, and an equal weight of hydroxypinacolone retinoic acid ester is used to replace the oligopeptide.

[0121] Comparative Preparation Examples 7-8

[0122] An anti-aging composition, which is different from Preparation Example 1 in that the components and their weights are shown in the following table:

[0123]

[0124] The anti-aging compositions obtained in the above comparative preparation examples 1-8 were subjected to hydroxyl radical scavenging rate detection and DPPH radical scavenging rate detection, and the test results are as follows:

[0125]

[0126]

[0127] Comparing the test results of Preparation Example 1 with those of Comparative Preparation Examples 1-6, it can be seen that the anti-wrinkle composition obtained in Preparation Example 1 has a higher hydroxyl radical scavenging rate and DPPH radical scavenging rate. This shows that in the total raw materials for the preparation of the anti-wrinkle composition of the present application, the compounding of hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides has a certain synergistic effect, which can improve the antioxidant capacity of the anti-wrinkle composition. The reason for this analysis may be that although retinol has strong antioxidant activity, its stability is poorer than that of hydroxypinacolone retinoic acid ester, although troxerutin can absorb ultraviolet rays and scavenge free radicals. However, due to the lack of oligopeptides, the protective effect of troxerutin on retinol is weakened, so the hydroxyl radical scavenging rate and DPPH radical scavenging rate of the obtained anti-wrinkle composition are stronger.

[0128] Comparing the test results of Preparation Example 1 with those of Comparative Preparation Examples 7-8, it can be seen that the anti-wrinkle composition obtained in Preparation Example 1 has a higher hydroxyl radical scavenging rate and DPPH radical scavenging rate. This shows that in the total raw materials for preparing the anti-wrinkle composition of the present application, the weight ratio of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide is 1: (0.20-0.25): (6.5-7.0), the synergistic effect of the three is stronger, and the obtained anti-wrinkle composition has a higher antioxidant capacity. The anti-aging essence obtained in the examples and comparative examples of the present application was tested for skin elasticity and water content of the skin stratum corneum, and the detection method is as follows:

[0129] (1) Volunteer selection: Volunteers aged 35-55 years were selected. Their skin was healthy and free of damage and wrinkles, and their skin quality and stratum corneum water content were similar.

[0130] (2) Testing steps: The volunteers were divided into groups, with 5 people in each group. After cleaning their faces in the morning and evening, the volunteers in each group were treated with the anti-aging essence prepared in the example and the comparative example, respectively.

[0131] Anti-wrinkle test: The skin elasticity Cotometer MPA580 host manufactured by Courage + Khazaka of Germany was used, and the probe used was the Reviscometer RV600 elastic fiber tissue test probe. The skin elasticity index of the forehead area 2 cm above the center of the eyebrows of the volunteers was measured before and 8 weeks after using the anti-aging essence. The index was recorded as the skin elasticity index before 8 weeks and the water content of the skin stratum corneum after 8 weeks. The negative pressure was kept constant at 450 mbar during the test. Each group was tested three times in parallel. The test results were averaged, and then the relative change of the skin elasticity index after 8 weeks was calculated. The calculation formula is as follows:

[0132] 8-week skin elasticity index change% = (8-week skin elasticity index - 8-week skin elasticity index) / 8-week skin elasticity index * 100%;

[0133] Skin stratum corneum moisture content detection: A skin stratum corneum moisture tester model ASA-MX100 purchased from Guining (Shanghai) Experimental Equipment Co., Ltd. was used to test the volunteers' skin stratum corneum moisture content in the forehead area 2 cm above the center of the brow before using the anti-aging essence and 8 weeks after using the anti-aging essence. The moisture content was recorded as the skin stratum corneum moisture content 8 weeks ago and the skin stratum corneum moisture content 8 weeks later, respectively. Each group was tested three times in parallel, and the test results were averaged. Then the relative change in the skin stratum corneum moisture content in 8 weeks was calculated, and the calculation formula was as follows: Change in skin stratum corneum moisture content in 8 weeks (%) = (skin stratum corneum moisture content after 8 weeks - skin stratum corneum moisture content 8 weeks ago) / skin stratum corneum moisture content 8 weeks ago * 100%.

[0134] Example

[0135] Example 1

[0136] An anti-aging serum, the components and their corresponding weights are shown in the following table:

[0137]

[0138] The preparation method of the anti-aging essence comprises the following preparation steps:

[0139] S1: PEG-40 hydrogenated castor oil and acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer were stirred and mixed at 85° C. and 45 r / min for 15 min to obtain a mixed solution;

[0140] S2: water, butanediol, xanthan gum and p-hydroxyacetophenone were stirred and mixed at 85°C and 45 r / min for 15 min, and then the mixed solution obtained in S1 was added, and then stirred and mixed at 0.1 MPa and 45 r / min for 10 min to obtain a mixture;

[0141] S3: Cool the mixture to 45°C, then add the anti-aging composition, oligomeric sodium hyaluronate, acetylated sodium hyaluronate and aminomethyl propanol, stir and mix for 10 minutes at 25 r / min, cool to 40°C, take samples and inspect them, and obtain the anti-aging essence.

[0142] In the examples of the present application, the anti-aging composition is prepared by Preparation Example 1.

[0143] Oligomeric sodium hyaluronate, cosmetic grade, brand ty, molecular weight 5000-10,000, purchased from Green Union (Jining) Chemical Technology Co., Ltd.

[0144] Acetylated sodium hyaluronate, cosmetic grade, model KS123, was purchased from Qingdao Keys Biotechnology Co., Ltd.

[0145] Example 2-3

[0146] An anti-aging essence, which is different from Example 1 in that the components and their corresponding weights are shown in the following table:

[0147]

[0148] The anti-aging essences obtained in Examples 1-3 of the present application were subjected to skin elasticity testing and skin stratum corneum water content testing, and the test results are shown in the following table:

[0149]

[0150] By analyzing the data in the above table, it can be seen that after the volunteers used the anti-aging essence obtained in Examples 1-3 for 8 weeks, the change in skin elasticity index was as high as 46.32-56.35%, and the change in skin stratum corneum water content was as high as 50.63-62.41% in 8 weeks. This shows that the anti-aging essence obtained in Examples 1-3 of the present application has good anti-wrinkle effect and moisturizing effect.

[0151] Embodiment 4-12

[0152] An anti-aging essence, which is different from Example 1 in that the anti-wrinkle composition is prepared by the preparation examples in the following table.

[0153]

[0154]

[0155] The anti-aging essences obtained in Examples 4-12 of the present application were subjected to skin elasticity testing and skin stratum corneum water content testing, and the test results are shown in the following table:

[0156]

[0157] By analyzing the data in the above table, it can be seen that after the volunteers used the anti-aging essence obtained in Examples 1-12 for 8 weeks, the change in skin elasticity index was as high as 47.32-55.60%, and the change in skin stratum corneum water content was as high as 51.56-61.32% in 8 weeks. This shows that the anti-aging essence prepared by using the anti-aging composition of Preparation Examples 1-10 of the present application has good anti-wrinkle effect and moisturizing effect.

[0158] Comparative Example

[0159] Comparative Examples 1-8

[0160] An anti-aging essence, which is different from Example 1 in that the anti-wrinkle composition is prepared by the preparation examples in the following table.

[0161] Group Preparation Example of Anti-Wrinkle Composition Comparative Example 1 Comparative Preparation Example 1 Comparative Example 2 Comparative Preparation Example 2 Comparative Example 3 Comparative Preparation Example 3 Comparative Example 4 Comparative Preparation Example 4 Comparative Example 5 Comparative Preparation Example 5 Comparative Example 6 Comparative Preparation Example 6 Comparative Example 7 Comparative Preparation Example 7 Comparative Example 8 Comparative Preparation Example 8

[0162] The anti-aging essences obtained in Comparative Examples 1-8 of the present application were subjected to skin elasticity testing and skin stratum corneum water content testing, and the test results are shown in the following table:

[0163]

[0164] Comparing the test results of Example 1 with those of Comparative Examples 1-6, it can be seen that after the volunteers used the anti-wrinkle essence obtained in Example 1 for 8 weeks, the 8-week skin elasticity index change and the 8-week skin stratum corneum water content change were higher, and the volunteers had higher skin elasticity and skin stratum corneum water content. This shows that the anti-wrinkle composition prepared by compounding hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide has a certain synergistic effect, which can improve the anti-wrinkle effect and moisturizing effect of the prepared anti-wrinkle essence.

[0165] By comparing the test results of Example 1 with those of Comparative Examples 7 and 8, it can be seen that when the anti-aging composition is composed of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide in a weight ratio of 1: (0.20-0.25): (6.5-7.0), the anti-wrinkle effect and moisturizing effect of the anti-aging essence finally prepared can be improved.

[0166] The anti-aging essence obtained in Examples 1-12 and Comparative Examples 1-8 of the present application was tested for retinoic acid content by HPLC with reference to the standard of "Technical Specification for Safety of Cosmetics" (2015). The test results showed that the anti-aging essence obtained in Examples 1-12 was stored in the dark at 25°C for 90 days, and the retinoic acid content was in the range of 0.1-0.2ppm, and the retinoic acid content was in the range of 0.3-0.6ppm when stored in the dark at 40°C for 90 days. The anti-aging essence obtained in Comparative Examples 1-8 was stored in the dark at 25°C for 90 days, and the retinoic acid content was in the range of 2.0-5.6ppm, and the retinoic acid content was in the range of 4.2-10.6ppm when stored in the dark at 40°C for 90 days. This indicates that when the anti-wrinkle composition composed of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide in a weight ratio of 1:(0.20-0.25):(6.5-7.0) is added to the anti-aging essence, the anti-wrinkle composition is not easily converted into retinoic acid, has good stability, and can exert a greater anti-aging effect.

[0167] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. An anti-aging composition, characterized in that: The invention is composed of a mixture of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide, wherein the weight ratio of hydroxypinacolone retinoic acid ester, Buddleja buddleja extract and oligopeptide is 1:(0.20-0.25):(6.5-7.0).

2. The anti-aging composition according to claim 1, characterized in that The hydroxypinacolone retinoic acid ester, buddleja flower extract and oligopeptide are mixed in a weight ratio of 1:0.22:6.

8.

3. The anti-aging composition according to claim 1, characterized in that The oligopeptide is one or more of oligopeptide-1, oligopeptide-3 and oligopeptide-5.

4. The anti-aging composition according to claim 3, characterized in that The oligopeptide is composed of a mixture of oligopeptide-1, oligopeptide-3 and oligopeptide-5, and the weight ratio of oligopeptide-1, oligopeptide-3 and oligopeptide-5 is 1:(0.2-0.6):(0.4-0.8).

5. An anti-aging cosmetic, characterized in that: The invention comprises the anti-aging composition and cosmetic accessories as described in any one of claims 1 to 4.

6. The anti-aging cosmetic according to claim 5, characterized in that: Calculated by weight percentage of the cosmetic, the added amount of the anti-aging composition is 0.01-0.023%.

7. The anti-aging cosmetic according to claim 5, characterized in that: The cosmetic is one of skin care lotion, essence, emulsion or cream.

8. An anti-aging essence, characterized in that: Calculated by weight percentage, it consists of the following components composition: 0.01-0.023% of the anti-aging composition according to any one of claims 1-4; Sodium oligomeric hyaluronate 0.5-1%; Acetylated sodium hyaluronate 0.5-1%; Butanediol 4-10%; PEG-40 hydrogenated castor oil 0.02-0.03%; Xanthan gum 0.1-0.2%; Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.3-1%; Aminomethyl propanol 0.02-0.05%; p-Hydroxyacetophenone 0.01-0.1%; Water is the balance.

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