A kind of dampness-removing Chinese medicine combination preparation and preparation method thereof

Abstract

The present invention provides a dehumidifying Chinese medicine combination preparation and a preparation method thereof. Six Chinese medicine materials, including tulip, lotus stem, bitter melon root, white orchid, red cang vine and osmanthus, are ultrafinely ground, and the cells are broken and then steamed at high temperature and high pressure. The obtained Chinese medicine steaming liquid is spray dried, and the powder obtained is collected and directly made into powder packaging or into any one of capsules, tablets and granules. The Chinese medicine preparation method of the present invention is simple, can make full use of the medicinal materials themselves, can effectively and quickly dehumidify through the synergistic effect of each Chinese medicine, and has low use cost. 15 grams are taken each time. Take it twice a day with warm water, and it can effectively dehumidify after 5 days.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a dampness-removing traditional Chinese medicine combination preparation and a preparation method thereof. Background Art

[0002] According to traditional Chinese medicine, dampness can be divided into external dampness and internal dampness. External dampness is mostly caused by the dampness invading the skin due to the natural climate or long-term exposure to dampness, or by being caught in rain and wading in water. Symptoms include aversion to cold and fever, swelling of the head, edema of the limbs, heaviness and pain in the body, etc., which are mostly diseases of the skin and meridians. Internal dampness is caused by excessive consumption of raw and cold food and excessive drinking, which leads to the dysfunction of spleen yang and the generation of dampness from within. Symptoms include chest fullness, abdominal distension, nausea, jaundice, diarrhea, stranguria, edema of the feet and insteps, etc., which are mostly diseases of the internal organs, qi and blood. Although dampness can be improved by adjusting diet or daily life, it is often slow to take effect and not practical. Summary of the invention

[0003] The present invention provides a dehumidifying Chinese medicine combination preparation and a preparation method thereof. The dehumidifying Chinese medicine combination preparation of the present invention can not only quickly dehumidify, but also strengthen the spleen and stomach, dispel cold, and promote the body's natural dehumidification, thereby fundamentally removing external and internal dampness.

[0004] In order to achieve the above-mentioned purpose, the present invention adopts the following specific technical solutions:

[0005] One of the technical solutions adopted by the present invention to solve the technical problem is: to provide a dehumidifying Chinese medicine combination preparation, which is composed of the following components by weight: 10-20 parts of tulip, 10-20 parts of lotus stem, 10-15 parts of bitter melon root, 5-10 parts of white jasmine, 10-20 parts of red cang vine, and 10-20 parts of osmanthus.

[0006] Furthermore, the dosage of the Chinese medicinal raw materials is: 15-20 parts of tulip, 15-20 parts of lotus stem, 13-15 parts of bitter melon root, 8-10 parts of white jasmine, 15-20 parts of red cang vine, and 15-20 parts of osmanthus.

[0007] Furthermore, the dosage of the Chinese medicinal raw materials is: 20 parts of tulip, 20 parts of lotus stem, 15 parts of bitter melon root, 10 parts of white jasmine, 20 parts of red cang vine, and 20 parts of osmanthus.

[0008] The second technical solution adopted by the present invention to solve the technical problem is: to provide a method for preparing a dehumidifying Chinese medicine combination preparation, comprising the following steps:

[0009] S1. Select the following raw materials by weight: 10-20 parts of tulips, 10-20 parts of lotus stems, 10-15 parts of bitter melon roots, 5-10 parts of white jasmine, 10-20 parts of red cang vine, 10-20 parts of osmanthus, after preparation, after ultrafine grinding and wall breaking treatment, to prepare a mixed powder of traditional Chinese medicine;

[0010] S2. Add water in a mass ratio of 0.5:1 between the mixed Chinese medicine powder and water in step S1, and cook in a sealed can at 110°C for 30 minutes. After cooling, obtain the Chinese medicine cooking liquid, directly fill the liquid to make a Chinese medicine beverage or oral liquid, or spray-dry the obtained Chinese medicine liquid, set the inlet temperature to 110°C and the outlet temperature to 70°C, and collect the spray-dried powder to obtain the Chinese medicine combination preparation.

[0011] The above solution has the following advantages:

[0012] 1. The medicinal materials of the present invention are firstly subjected to ultrafine grinding and cell wall breaking treatment, and then subjected to high temperature and high pressure cooking at 110°C for 30 minutes, which effectively improves the dissolution of active ingredients of the medicine and enhances the efficacy. Compared with the traditional Chinese medicine extraction method, this method is simple to operate and low in cost.

[0013] 2. After spray drying, the Chinese medicine cooking liquid retains the effective ingredients extracted from the Chinese medicine and the medicinal materials themselves, thereby increasing the utilization rate of the medicinal materials.

[0014] 3. Using red cangcunia as a diuretic can promote urine discharge, which is beneficial to assist in removing dampness. Osmanthus fragrans has the effects of warming the lungs and dispelling cold, and can strengthen the spleen and nourish the stomach, so as to ensure that while removing dampness, it can protect the internal organs and can effectively improve the taste problem of the Chinese medicine compatibility of the present invention.

[0015] The pharmacology of the Chinese medicine of the present invention is as follows:

[0016] Tulip: bitter, spicy, neutral in nature. It has the effects of removing dampness, deodorizing, and removing filth, and is aromatic. It is mostly used to treat spleen and stomach dampness, stomach fullness, vomiting, abdominal pain, and bad breath.

[0017] Lotus stem: bitter, neutral in nature, enters the spleen and bladder meridians. Functions: relieving summer heat, clearing away heat, regulating qi and removing dampness, ventilating and widening the chest, and harmonizing the stomach. Indications: chest tightness and discomfort caused by summer heat and dampness; diarrhea; dysentery; gonorrhea.

[0018] Bitter melon root: bitter in taste, cold in nature, has the effects of clearing dampness and heat and detoxifying, and is often used for damp-heat diarrhea, bloody stool, carbuncle, swelling and toxins, and toothache caused by wind and fire.

[0019] White jasmine: bitter, spicy, warm in nature. It has the effects of clearing away heat, relieving summer heat, promoting urination, dispelling cold, opening the orifices, promoting qi and removing dampness.

[0020] Red Cangteng: bitter in taste, neutral in nature, has the effects of clearing away heat and dampness, promoting diuresis and relieving stranguria, and treating damp-heat in the liver and gallbladder.

[0021] Osmanthus: spicy, warm in nature, enters the lung, liver, and stomach meridians. Warms the lungs and transforms fluid, dispels cold and relieves pain, and induces sweating to relieve the symptoms.

[0022] The present invention mainly uses tulip, lotus stem, red cang tung, and sweet osmanthus to strengthen the spleen and nourish the stomach, dispel cold, eliminate dampness, gently protect the operation of various organs of the body, and promote the body's natural dehumidification. It is supplemented with bitter melon root and red cang tung to clear dampness and heat and detoxify. At the same time, red cang tung and white jasmine have diuretic and stranguria, heat-clearing and summer-heat-relieving effects, and can effectively and quickly promote the discharge of moisture. The dehumidifying Chinese medicine combination of the present invention has reasonable warm and cold collocation of each Chinese medicine, and the multi-flavor Chinese medicine tastes bitter. Sweet osmanthus is supplemented as a regulation to make the taste better. DETAILED DESCRIPTION

[0023] In order to better understand the present invention, the present invention is further described in detail below in conjunction with the embodiments. However, those skilled in the art understand that the following embodiments are not limitations on the scope of protection of the present invention, and any changes and modifications made on the basis of the present invention are within the scope of protection of the present invention.

[0024] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0025] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0026] Example 1 Preparation of a Chinese herbal medicine combination preparation for removing dampness

[0027] Tulip, lotus stem, bitter melon root, white orchid, red cang vine, and osmanthus were used as experimental Chinese medicines to optimize the dosage of Chinese medicines and screen out the dosage of Chinese medicines that can effectively and quickly remove dampness. According to the preferred dosage combination, after the preparation is completed, it is subjected to ultrafine grinding and wall breaking treatment to make a mixed Chinese medicine powder. The specific Chinese medicine compatibility is shown in Table 1. Water is added to the mixed Chinese medicine powder in a mass ratio of 0.5:1, and it is boiled at 110℃ in a sealed can for 30min. After cooling, the Chinese medicine boiling liquid is obtained and spray-dried. Set the inlet temperature to 110℃ and the outlet temperature to 70℃, collect the spray-dried powder, which is the dehumidifying Chinese medicine combination preparation.

[0028] Table 1 Optimized combination of Chinese medicine raw material formula

[0029] Serial number tulip Lotus stem Bitter Melon Root White Orchid Red Cang Teng Osmanthus fragrans Combination 1 10 10 10 5 10 10 Combination 2 15 15 13 8 15 15 Combination 3 20 20 15 10 20 20 Combination 4 18 18 14 9 14 18 Combination 5 20 20 15 10 / 20 Combination 6 20 20 15 10 15 /

[0030] Example 2 Safety test in mice

[0031] 70 mice were selected and divided into 7 groups after 1 week of temporary feeding, half of which were male and half were female. During the feeding period, the mice in each group had free access to water and were managed in the same manner. Among them, the experimental groups 1-6 were fed with the combination 1-6 of Example 1, and were orally gavaged at 1% of the body weight of the mice, twice a day, for 15 consecutive days. The control group was not given any medicine, and the mice were observed for abnormal feeding, drinking, movement and behavior during the feeding test.

[0032] The test results showed that during the test period, all mice showed no abnormal performance and no death. Two mice were randomly selected from each of the seven groups for dissection, and no lesions or abnormalities were observed in the internal organs, indicating that the combination 1-6 of Example 1 is not pathogenic to mice within a reasonable usage amount.

[0033] Example 3 Efficacy Test

[0034] 93 patients diagnosed with dampness, manifested as greasy tongue, unformed stool, or heavy body, sourness and weakness, or joint disadvantage, or tasteless and greasy mouth, or abdominal distension and headache, or fat body and much phlegm, or tinea and acne on hands, feet and face, etc., were divided into 7 groups according to the principle of voluntariness. Wherein the control group was taken according to the instructions for use of a heat-clearing and damp-removing granule, and the treatment group 6 groups adopted the damp-removing Chinese medicine combination preparation combination 1-6 of the embodiment 1 of the present invention, each time taking 15 grams, 1 day 2 times warm water delivery, and the patient's damp-removing situation was counted after 5 days. Judgment criteria: recovery means that the symptoms involved disappear completely, and the person returns to normal; effective means that the symptoms involved are alleviated or some symptoms disappear; invalid means that it does not have any effect, and the symptoms are not improved.

[0035] Total effective rate (%) = (cured + effective) ÷ total number of test groups

[0036] Table 2 Efficacy test results of the Chinese medicine combination preparation of the present invention

[0037] Group get well efficient invalid Total Effectiveness Group 1 (13 people) 5 5 3 76.9％ Group 2 (15 people) 8 4 3 80.0％ Group 3 (14 people) 10 2 2 85.7％ Group 4 (11 people) 7 2 2 81.8％ Group 5 (15 people) 4 6 5 66.7％ Group 6 (12 people) 6 3 3 75.0％ Control group (13 people) 5 5 3 76.9％

[0038] As can be seen from the results in Table 2, combinations 2-4 have the best effects, among which combination 3 has the best effect. In combination 5, which lacks red cang vine in the Chinese medicine combination, the total effective rate is 66.7%, which is the worst effect in this experiment, indicating that red cang vine plays an important role in the dehumidifying Chinese medicine combination in this study; and in combination 6, which lacks osmanthus, the total effective rate is 75.0%, which is higher than combination 5, but patients report that the taste is poor. As for the control group using a certain heat-clearing and dehumidifying granule, its total effective rate is 76.9%, which is slightly worse than this study. And in the course of this experiment, patients who took the dehumidifying Chinese medicine combination preparation of the present invention had no adverse reactions or abnormal behaviors.

[0039] Typical Cases

[0040] Case 1

[0041] Zhang, male, 36 years old, had a rough, yellow tongue coating, blue stool, unformed stool, dry mouth, bitter taste, no appetite, and easy sweating. He took Combination 3 of Example 1, 15 grams each time, twice a day with warm water, and got better in 3 days, with formed stool and no more sweating. He continued to take the medicine of the present invention and recovered after 5 days.

[0042] Case 2

[0043] Li, female, 38 years old, had sticky mouth, greasy white tongue coating, fullness of chest and abdomen, short and astringent urine, heavy head, fatigue of limbs, and easy sweating. After taking Combination 3 of Example 1, 15 grams each time, twice a day with warm water, the condition improved in 2 days and was cured in 4 days.

[0044] Although the specific implementation modes of the present invention are described above, those skilled in the art should understand that the specific implementation modes described are only illustrative and are not intended to limit the scope of the present invention. Equivalent modifications and changes made by those skilled in the art in accordance with the spirit of the present invention should be included in the scope of protection of the claims of the present invention.

Claims

1. A Chinese medicine combination preparation for removing dampness, characterized in that: The invention is composed of the following ingredients by weight: 10-20 parts of tulip, 10-20 parts of lotus stem, 10-15 parts of bitter melon root, 5-10 parts of white jasmine, 10-20 parts of red cang vine and 10-20 parts of osmanthus.

2. The Chinese medicine combination preparation according to claim 1, characterized in that: The invention is composed of the following ingredients by weight: 15-20 parts of tulip, 15-20 parts of lotus stem, 13-15 parts of bitter melon root, 8-10 parts of white jasmine, 15-20 parts of red cang vine and 15-20 parts of osmanthus.

3. The Chinese medicine combination preparation according to claim 1, characterized in that: The invention is composed of the following ingredients by weight: 20 parts of tulip, 20 parts of lotus stem, 15 parts of bitter melon root, 10 parts of white jasmine, 20 parts of red cang vine and 20 parts of osmanthus.

4. A method for preparing a dehumidifying Chinese medicine combination preparation, characterized in that: The steps include: S1. Select the following raw materials by weight: 10-20 parts of tulips, 10-20 parts of lotus stems, 10-15 parts of bitter melon roots, 5-10 parts of white jasmine, 10-20 parts of red cang vine, 10-20 parts of osmanthus, after preparation, after ultrafine grinding and wall breaking treatment, to prepare a mixed powder of traditional Chinese medicine; S2. Add water in a mass ratio of 0.5:1 between the mixed Chinese medicine powder and water in step S1, and cook in a sealed can at a temperature of 110°C for 30 min. After cooling, obtain the Chinese medicine cooking liquid, directly fill the liquid to make a Chinese medicine beverage or oral liquid, or spray-dry the obtained Chinese medicine liquid, set the inlet temperature to 110°C and the outlet temperature to 70°C, and collect the spray-dried powder to obtain the Chinese medicine combination preparation.