Hydrogen peroxide gel containing dexamethasone or sodium cholate compounds and preparation method thereof

Abstract

The present invention relates to the technical field of supramolecular gel, specifically a hydrogen peroxide gel containing dexamethasone or sodium cholate compounds and a preparation method thereof, wherein the gel comprises, by mass percentage: 88% to 99.4% of a hydrogen peroxide aqueous solution with a mass concentration of 30% to 98%; a gelling agent: 0.25% to 5%; an inorganic crosslinking agent: 0.1% to 5%; a stabilizer: 0.1% to 2%; the gelling agent comprises one or more of a dexamethasone compound or a sodium cholate compound. The preparation method is that the gelling agent is in a 30% to 98% hydrogen peroxide aqueous solution, and the inorganic crosslinking agent forms a semisolid gel through ion coordination, thereby reducing the risk of leakage of the hydrogen peroxide solution during storage, transportation and application. The present invention provides a method for preparing hydrogen peroxide gel under simple process conditions, and the time required for gelation can be controlled by partially adjusting the temperature, so as to facilitate industrial application.

Description

Technical Field

[0001] The invention relates to the technical field of supramolecular gel, in particular to a hydrogen peroxide gel containing dexamethasone or sodium cholate compounds and a preparation method thereof. Background Art

[0002] Hydrogen peroxide is a high-density, strongly oxidizing liquid composed of hydrogen and oxygen elements. Its decomposition products are water and oxygen. Due to its high energy and environmentally friendly decomposition products, it has become a research hotspot in various countries in the field of propellants. However, the strong oxidizing, flammable and explosive, and easy flow characteristics of hydrogen peroxide liquid bring great risks to the leakage that may be caused and exist during the application process.

[0003] The gelation of hydrogen peroxide is beneficial to reduce the risk of leakage in its liquid flow state and increase the safety factor during storage, transportation and application. By adding a gelling agent to a hydrogen peroxide solution, a semi-solid with a three-dimensional network structure is formed through physical or chemical cross-linking. The hydrogen peroxide solution will be confined in the three-dimensional network gap formed by the cross-linking agent as a dispersion medium, so the fluidity of the hydrogen peroxide solution can be effectively reduced and the risk of leakage can be reduced. At present, there is no existing technology for improving the storage and transportation stability of hydrogen peroxide through gelation.

[0004] In view of this, it is necessary to design an improved hydrogen peroxide gel and a preparation method thereof to solve the above problems. Summary of the invention

[0005] The object of the present invention is to provide a hydrogen peroxide gel containing dexamethasone or sodium cholate compounds and a preparation method thereof, so as to reduce the leakage risk of hydrogen peroxide solution during storage, transportation and application, and reduce the gelation cost to adapt to industrial application.

[0006] To achieve the above object, in a first aspect, the present invention provides a hydrogen peroxide gel, comprising, by mass percentage:

[0007] Aqueous hydrogen peroxide solution with a mass concentration of 30% to 98%: 88% to 99.4%;

[0008] Gel: 0.25% to 5%;

[0009] Inorganic crosslinking agent: 0.1% to 5%;

[0010] Stabilizer: 0.1%~2%;

[0011] The gelling agent comprises one or more of dexamethasone compounds or sodium cholate compounds, and the stabilizer is at least one of phosphoric acid, sodium silicate, ATMP, EDTMP, DETPMP, HEDP, Span 80 and Tween 60.

[0012] Furthermore, the hydrogen peroxide gel comprises, by mass percentage:

[0013] Aqueous hydrogen peroxide solution with a mass concentration of 30% to 98%: 92% to 99.4%;

[0014] Dexamethasone compounds: 0.25% to 3%;

[0015] Inorganic crosslinking agent: 0.25% to 3%;

[0016] Stabilizer: 0.1%~2%.

[0017] The present invention studies show that dexamethasone compounds or sodium cholate compounds and inorganic crosslinking agents form a three-dimensional network structure under the action of ion coordination, which can gel the high-concentration hydrogen peroxide aqueous solution, thereby effectively reducing the leakage risk of the hydrogen peroxide solution during storage, transportation and application.

[0018] When the concentration or content of the aqueous hydrogen peroxide solution is too low, it is not conducive to controlling the storage and transportation costs, and the shear fluidity after gelation is poor, which is not conducive to reuse.

[0019] In some embodiments, the mass percentage of the dexamethasone compound is 0.25%, 0.4%, 0.5%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 4% and the like; the mass percentage of the inorganic cross-linking agent is 0.25%, 0.4%, 0.5%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 4% and the like.

[0020] Furthermore, the hydrogen peroxide gel comprises, by mass percentage:

[0021] Aqueous hydrogen peroxide solution with a mass concentration of 30% to 98%: 88% to 98%;

[0022] Sodium bile acid compounds: 0.5% to 5%;

[0023] Inorganic crosslinking agent: 0.1% to 5%;

[0024] Stabilizer: 0.1%~2%.

[0025] The research of the present invention shows that the sodium cholate compounds are cross-linked by the coordination effect of an inorganic cross-linking agent at room temperature to obtain a hydrogen peroxide hydrogel with a three-dimensional network structure.

[0026] Further, the dexamethasone compound includes one or more of dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate, and dexamethasone phosphate. Preferably, the dexamethasone compound is at least one of dexamethasone, dexamethasone sodium phosphate, and dexamethasone acetate.

[0027] The sodium bile acid compound is at least one of sodium bile acid, sodium deoxycholate, sodium lithocholate, sodium hyocholate, hyodeoxycholic acid, sodium chenodeoxycholate, and sodium ursodeoxycholate. The structural formula of the sodium bile acid compound is as follows:

[0028]

[0029] Further, the inorganic crosslinking agent includes one or more of calcium nitrate, calcium chloride, magnesium sulfate, strontium acetate, strontium chloride, strontium nitrate, magnesium chloride, magnesium nitrate, magnesium phosphate, calcium hydrogen phosphate, and calcium dihydrogen phosphate. Preferably, the inorganic crosslinking agent is at least one of calcium nitrate tetrahydrate, calcium chloride, magnesium sulfate, strontium acetate, and strontium nitrate.

[0030] In some embodiments, the mass concentration of the aqueous hydrogen peroxide solution is 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% and the like; the mass percentage of the aqueous hydrogen peroxide solution is 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% and the like.

[0031] In a second aspect, the present invention provides a method for preparing the hydrogen peroxide gel described in any one of the above items, comprising: uniformly mixing a hydrogen peroxide aqueous solution, a gelling agent and an inorganic crosslinking agent according to mass percentage at low temperature, and then raising the temperature and standing to gel, thereby obtaining the hydrogen peroxide gel. As the temperature increases, the gelling time gradually shortens.

[0032] The preparation method of the invention has simple process and readily available raw materials, thus meeting the requirements of industrial production.

[0033] In some embodiments, the method for preparing hydrogen peroxide gel comprises:

[0034] S1, mixing part of the aqueous hydrogen peroxide solution and the dexamethasone compound and stirring evenly;

[0035] S2, mixing the remaining hydrogen peroxide aqueous solution with the inorganic crosslinking agent and the stabilizer and stirring evenly;

[0036] S3. At low temperature, the solution obtained in step S1 is mixed with the solution obtained in step S2, and then the temperature is raised and allowed to stand to form a gel to obtain hydrogen peroxide gel, which is stored at low temperature.

[0037] Furthermore, the temperature range of the low-temperature mixing is -40 to -10°C, preferably -25 to -15°C.

[0038] Furthermore, the temperature of the static gelling is 0 to 30°C, preferably 15 to 30°C.

[0039] Furthermore, the amount of the aqueous hydrogen peroxide solution in step S1 is 30-70% of the total amount, preferably 40-60%, and more preferably 50%.

[0040] Furthermore, in steps S1 and S2, the mixing and stirring rate is 500 to 2500 r / min, preferably 600 to 2000 r / min; the time is 0.1 to 5 h; preferably 0.5 to 3 h.

[0041] And / or, steps S1 and S2 are both performed at normal temperature and pressure.

[0042] Furthermore, in step 3, the temperature of the low-temperature storage is -10 to 5°C, preferably -10 to 0°C.

[0043] Specifically, the hydrogen peroxide gel preparation method comprises:

[0044] S1. Adding a dexamethasone compound to an aqueous hydrogen peroxide solution at room temperature and pressure, and stirring until the compound is completely dispersed or dissolved;

[0045] S2. At room temperature and pressure, add an inorganic crosslinking agent and a stabilizer to the aqueous hydrogen peroxide solution, and stir until they are completely dispersed or dissolved;

[0046] S3. The hydrogen peroxide solution obtained in step S1 and the hydrogen peroxide solution obtained in step S2 are mixed at a low temperature (-40 to -10°C), shaken evenly, and then the resulting mixed solution is placed at a specific temperature (15 to 30°C) to stand to form a gel, and then stored at a low temperature of -10 to 0°C.

[0047] In some embodiments, the method for preparing hydrogen peroxide gel comprises:

[0048] S1, mixing the aqueous hydrogen peroxide solution and the sodium cholate compound and stirring them uniformly to obtain a viscous hydrogen peroxide sol;

[0049] S2, adding an inorganic crosslinking agent to the hydrogen peroxide sol, stirring until the crosslinking agent is completely dispersed or dissolved, then adding a stabilizer, stirring until the mixture is uniform, and standing at room temperature to obtain a hydrogen peroxide gel. In steps S1 and S2, the mixing and stirring rate is 500 to 2500 r / min, and the time is 0.5 to 5 hours;

[0050] And / or, steps S1 and S2 are both carried out at room temperature and pressure; the low-temperature storage temperature is -10 to 5°C.

[0051] The beneficial effects of the present invention are as follows:

[0052] 1. The hydrogen peroxide gel provided by the present invention forms a solid gel through the ion coordination of dexamethasone compounds or sodium cholate compounds and inorganic crosslinking agents, which can achieve the gelation of high-concentration hydrogen peroxide and reduce the leakage risk of hydrogen peroxide solution during storage, transportation and application. Moreover, the gel has a certain shear fluidity and is easy to use.

[0053] 2. The dexamethasone compounds and inorganic cross-linking agents used in the present invention have mature preparation processes and are cheap and readily available.

[0054] 3. The present invention can prolong or shorten the gelling time by controlling the standing temperature. The raw materials and preparation method are simple and easy to operate, and are convenient for industrial application. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0056] Figure 1 This is a scanning electron microscope (SEM) image of the dexamethasone-containing hydrogen peroxide gel prepared in Example 1.

[0057] Figure 2 This is a scanning electron microscope (SEM) image of the dexamethasone-containing hydrogen peroxide gel prepared in Example 1 at another scale.

[0058] Figure 3 This is a scanning electron microscope (SEM) image of the bile acid hydrogen peroxide gel prepared in Example 7.

[0059] Figure 4 This is a scanning electron microscope (SEM) image of the bile acid hydrogen peroxide gel prepared in Example 7 at another scale.

[0060] Figure 5 This is a photo of the hydrogen peroxide gel prepared in Example 1 placed upside down in a bottle.

[0061] Figure 6 This is a physical picture of the extrusion process of the hydrogen peroxide gel prepared in Example 1.

[0062] Figure 7 This is a photo of the hydrogen peroxide gel prepared in Example 7 placed upside down in a bottle.

[0063] Figure 8 This is a physical picture of the extrusion process of the hydrogen peroxide gel prepared in Example 7. DETAILED DESCRIPTION

[0064] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention is described clearly and completely below. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0065] Example 1

[0066] This embodiment provides a hydrogen peroxide gel containing a dexamethasone compound, the components and mass ratios of which are shown in Table 1.

[0067] Table 1 Components and mass ratios

[0068] Recipe composition Content / %wt 90% hydrogen peroxide aqueous solution 98.1 Dexamethasone sodium phosphate 1 Strontium acetate 0.4 Span 80 0.5

[0069] This embodiment also provides a method for preparing the above-mentioned dexamethasone-containing hydrogen peroxide gel, comprising the following steps:

[0070] Step 1: Weigh 10 mg of dexamethasone sodium phosphate and add it to 500 mg of 90% aqueous hydrogen peroxide solution, and stir at 1500 r / min at room temperature and pressure for 0.5 h until it is completely dissolved.

[0071] Step 2: Weigh 4 mg of strontium acetate and 5 mg of Span 80, add them into 500 mg of 90% aqueous hydrogen peroxide solution, and stir at 1500 r / min at room temperature and pressure for 0.5 h until they are completely dissolved.

[0072] Step 3, the solutions obtained in step 1 and step 2 are mixed at a temperature of -20°C, shaken and mixed, and the resulting mixture is placed at a temperature of 15°C and allowed to stand for 3 hours to obtain hydrogen peroxide gel. When the standing temperature is increased to 30°C, the hydrogen peroxide gel is obtained after standing for 1 hour, and then stored at a low temperature of -5°C.

[0073] like Figure 1 and 2 As shown, it can be seen that in this system, the dexamethasone compound first forms a one-dimensional nanofibrous structure with the inorganic cross-linking agent under the influence of ion coordination, and the mutual cross-linking of multiple nanofibers gradually forms a three-dimensional network structure. The hydrogen peroxide aqueous solution is therefore restricted in the grid and cannot move freely, thereby losing fluidity and forming a hydrogen peroxide gel.

[0074] like Figure 5As shown (the left side is the initial state, and the right side is the state after one week of placement), it can be seen that when the hydrogen peroxide gel is placed upside down in the bottle, the gel basically does not flow only under the action of gravity, indicating that its fluidity is significantly reduced compared to the hydrogen peroxide solution, which is convenient for stable storage.

[0075] from Figure 6 It can be seen that when the hydrogen peroxide gel is subjected to an atmospheric pressure, the gel will be squeezed out like a liquid. The hydrogen peroxide gel in the storage tank can be transported to the application end through the connected pipeline just like hydrogen peroxide solution by simply applying pressure, which improves storage safety while still being easy to use.

[0076] Example 2

[0077] This embodiment provides a hydrogen peroxide gel containing a dexamethasone compound, the components and mass ratios of which are shown in Table 2.

[0078] Table 2 Components and mass ratios

[0079]

[0080]

[0081] This embodiment also provides a method for preparing the above-mentioned dexamethasone-containing hydrogen peroxide gel, comprising the following steps:

[0082] Step 1: Weigh 10 mg of dexamethasone sodium phosphate and add it to 500 mg of 90% aqueous hydrogen peroxide solution, and stir at room temperature at a speed of 1500 r / min for 0.5 h until it is completely dissolved.

[0083] Step 2: Weigh 4.6 mg of calcium nitrate tetrahydrate and 5 mg of Span 80, add them to 500 mg of 90% aqueous hydrogen peroxide solution, stir at room temperature at a speed of 1500 r / min for 0.5 h until completely dissolved, and then store at -10°C.

[0084] Step 3, the solutions obtained in step 1 and step 2 are mixed at a temperature of -20°C, shaken and mixed, and the resulting mixture is placed at a temperature of 15°C and allowed to stand for 0.5h to obtain hydrogen peroxide gel. When the standing temperature is increased to 30°C, the hydrogen peroxide gel is obtained after standing for 10min.

[0085] Example 3

[0086] This embodiment provides a hydrogen peroxide gel containing a dexamethasone compound, the components and mass ratios of which are shown in Table 3.

[0087] Table 3 Components and mass ratios

[0088] Recipe composition Content / %wt 90% Hydrogen Peroxide Aqueous Solution 98.6 Dexamethasone sodium phosphate 1 Magnesium sulfate 0.2 Twain 60 0.2

[0089] This embodiment also provides a method for preparing the above-mentioned dexamethasone-containing hydrogen peroxide gel, comprising the following steps:

[0090] Step 1: Weigh 10 mg of dexamethasone sodium phosphate and add it to 500 mg of 90% aqueous hydrogen peroxide solution, and stir at room temperature at a speed of 1500 r / min for 0.5 h until it is completely dissolved.

[0091] Step 2: Weigh 2.3 mg of magnesium sulfate and 2 mg of Tween 60, add them into 500 mg of 90% aqueous hydrogen peroxide solution, and stir at room temperature at a speed of 1500 r / min for 0.5 h until they are completely dissolved.

[0092] Step 3, the solutions obtained in step 1 and step 2 are mixed at a temperature of -20°C, shaken and mixed, and the resulting mixture is placed at a temperature of 15°C and allowed to stand for 0.5 h to obtain hydrogen peroxide gel. When the standing temperature is increased to 30°C, the hydrogen peroxide gel is obtained after standing for 10 min, and then stored at a low temperature of -10°C.

[0093] Example 4

[0094] This embodiment provides a hydrogen peroxide gel containing a dexamethasone compound, the components and mass ratios of which are shown in Table 4.

[0095] Table 4 Components and mass ratios

[0096] Recipe composition Content / %wt 90% hydrogen peroxide aqueous solution 98.1 Dexamethasone sodium phosphate 1 Strontium nitrate 0.4 Twain 60 0.5

[0097] This embodiment also provides a method for preparing the above-mentioned dexamethasone-containing hydrogen peroxide gel, comprising the following steps:

[0098] Step 1: Weigh 10 mg of dexamethasone sodium phosphate and add it to 500 mg of 90% aqueous hydrogen peroxide solution, and stir at room temperature at a speed of 1500 r / min for 0.5 h until it is completely dissolved.

[0099] Step 2: Weigh 4 mg of strontium nitrate and 5 mg of Tween 60, add them into 500 mg of 90% aqueous hydrogen peroxide solution, and stir at room temperature at a speed of 1500 r / min for 0.5 h until they are completely dissolved.

[0100] Step 3, the solutions obtained in step 1 and step 2 are mixed at a temperature of -20°C, shaken and mixed, and the resulting mixture is placed at a temperature of 15°C and allowed to stand for 3 hours to obtain hydrogen peroxide gel. When the standing temperature is increased to 30°C, the hydrogen peroxide gel is obtained after standing for 1 hour, and then stored at a low temperature of -5°C.

[0101] Example 5

[0102] This embodiment provides a hydrogen peroxide gel containing a dexamethasone compound, the components and mass ratios of which are shown in Table 5.

[0103] Table 5 Components and mass ratios

[0104] Recipe composition Content / %wt 90% Hydrogen Peroxide Aqueous Solution 95 Dexamethasone sodium phosphate 3 Strontium acetate 1 Span 80 1

[0105] The preparation method is the same as that in Example 1 and will not be described again.

[0106] Example 6

[0107] This embodiment provides a hydrogen peroxide gel containing a dexamethasone compound, the components and mass ratios of which are shown in Table 6.

[0108] Table 6 Components and mass ratios

[0109] Recipe composition Content / %wt 90% hydrogen peroxide aqueous solution 95 Dexamethasone sodium phosphate 4 Strontium acetate 0.5 Span 80 0.5

[0110] The preparation method is the same as that in Example 1 and will not be described again.

[0111] Examples 1-6 can all produce hydrogen peroxide gels with slightly different fluidities.

[0112] Example 7

[0113] A sodium cholate-containing hydrogen peroxide gel propellant, the mass ratio and components contained are shown in Table 7:

[0114] Table 7 Mass ratio and components

[0115]

[0116]

[0117] This embodiment also provides a method for preparing the above-mentioned sodium cholate-containing hydrogen peroxide gel, comprising the following steps:

[0118] a. At room temperature and pressure, add sodium deoxycholate to 80% aqueous hydrogen peroxide solution and stir until the gelling agent is completely dispersed or dissolved to obtain a viscous hydrogen peroxide sol.

[0119] b. Add calcium nitrate to the hydrogen peroxide sol obtained in step a, stir until the calcium nitrate is completely dispersed or dissolved, then add phosphoric acid, stir until the mixture is uniform, and let stand at room temperature to obtain a hydrogen peroxide hydrogel, which is stored at -5°C.

[0120] like Figure 3 and 4As shown, it can be seen that in this system, the sodium cholate compounds first form a one-dimensional nanofibrous structure with the inorganic cross-linking agent under the influence of ion coordination, and the mutual cross-linking of multiple nanofibers gradually forms a three-dimensional network structure. The hydrogen peroxide aqueous solution is therefore restricted in the grid and cannot move freely, thereby losing fluidity and forming a hydrogen peroxide gel.

[0121] like Figure 7 As shown (the left side is the initial state, and the right side is the state after one week of placement), it can be seen that when the hydrogen peroxide gel is placed upside down in the bottle, the gel basically does not flow only under the action of gravity, indicating that compared with the hydrogen peroxide solution, its fluidity is significantly reduced, which is convenient for stable storage.

[0122] from Figure 8 It can be seen that when the hydrogen peroxide gel is subjected to an atmospheric pressure, the gel will be squeezed out like a liquid. The hydrogen peroxide gel in the storage tank can be transported to the application end through the connected pipeline just like hydrogen peroxide solution by simply applying pressure, which improves storage safety while still being easy to use.

[0123] Example 8

[0124] This embodiment provides a sodium cholate-containing hydrogen peroxide gel propellant, the mass ratio and components contained are shown in Table 8:

[0125] Table 8 Mass ratio and components

[0126]

[0127]

[0128] This embodiment also provides a method for preparing the above-mentioned sodium cholate-containing hydrogen peroxide gel, comprising the following steps:

[0129] a. At room temperature and pressure, add sodium cholate to a 50% aqueous hydrogen peroxide solution and stir until the gelling agent is completely dispersed or dissolved to obtain a viscous hydrogen peroxide sol.

[0130] b. Add magnesium sulfate to the hydrogen peroxide sol obtained in step a, stir until the magnesium sulfate is completely dispersed or dissolved, then add HEDP, stir until the mixture is uniform, and let stand at room temperature to obtain a hydrogen peroxide hydrogel, which is stored at -10°C.

[0131] Example 9

[0132] This embodiment provides a sodium cholate-containing hydrogen peroxide gel propellant, the mass ratio and components contained are shown in Table 9:

[0133] Table 9 Mass ratio and components

[0134] Recipe composition Content / %wt 98% concentration of hydrogen peroxide aqueous solution 96 Sodium chenodeoxycholate 2 Calcium Nitrate 1 EDTMP 1

[0135] This embodiment also provides a method for preparing the above-mentioned sodium cholate-containing hydrogen peroxide gel, comprising the following steps:

[0136] a. At room temperature and pressure, add sodium chenodeoxycholate to a 98% aqueous hydrogen peroxide solution and stir until the gelling agent is completely dispersed or dissolved to obtain a viscous hydrogen peroxide sol.

[0137] b. Add calcium nitrate to the hydrogen peroxide sol obtained in step a, stir until the calcium nitrate is completely dispersed or dissolved, then add EDTMP, stir until the mixture is uniform, and let stand at room temperature to obtain a hydrogen peroxide hydrogel, which is stored at 5°C.

[0138] Example 10

[0139] This embodiment provides a sodium cholate-containing hydrogen peroxide gel propellant, the mass ratio and components contained are shown in Table 10:

[0140] Table 10 Mass ratio and components

[0141] Recipe composition Content / %wt 90% concentration of hydrogen peroxide aqueous solution 95 Sodium ursodeoxycholate 3 Calcium sulfate 1 Phosphoric acid 1

[0142] This embodiment also provides a method for preparing the above-mentioned sodium cholate-containing hydrogen peroxide gel, comprising the following steps:

[0143] a. At room temperature and pressure, add sodium ursodeoxycholate to a 90% aqueous hydrogen peroxide solution and stir until the gelling agent is completely dispersed or dissolved to obtain a viscous hydrogen peroxide sol.

[0144] b. Add calcium sulfate to the hydrogen peroxide sol obtained in step a, stir until the calcium sulfate is completely dispersed or dissolved, then add phosphoric acid, stir until the mixture is uniform, and let stand at room temperature to obtain a hydrogen peroxide hydrogel, which is stored at 0°C.

[0145] Examples 7-10 can all produce hydrogen peroxide gels with slightly different fluidities.

[0146] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A hydrogen peroxide gel, It is characterized in that Included by mass percentage: Aqueous hydrogen peroxide solution with a mass concentration of 30% to 98%: 88% to 99.5%; Gel: 0.25% to 5%; Inorganic crosslinking agent: 0.1% to 5%; Stabilizer: 0.1%~2%; The gel comprises one or more of dexamethasone compounds or sodium cholate compounds.

2. The hydrogen peroxide gel according to claim 1, It is characterized in that The hydrogen peroxide gel comprises by mass percentage: Aqueous hydrogen peroxide solution with a mass concentration of 30% to 98%: 92% to 99.4%; Dexamethasone compounds: 0.25% to 3%; Inorganic crosslinking agent: 0.25% to 3%; Stabilizer: 0.1%~2%; The stabilizer is at least one of phosphoric acid, sodium silicate, ATMP, EDTMP, DETPMP, HEDP, Span 80 and Tween 60.

3. The hydrogen peroxide gel according to claim 1, It is characterized in that The hydrogen peroxide gel comprises by mass percentage: Aqueous hydrogen peroxide solution with a mass concentration of 30% to 98%: 88% to 99.3%; Sodium bile acid compounds: 0.5% to 5%; Inorganic crosslinking agent: 0.1% to 5%; Stabilizer: 0.1%~2%; The stabilizer is at least one of phosphoric acid, sodium silicate, ATMP, EDTMP, DETPMP, HEDP, Span 80 and Tween 60.

4. The hydrogen peroxide gel according to any one of claims 1 to 3, It is characterized in that The dexamethasone compound includes one or more of dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate, and dexamethasone phosphate; And / or, the structural formula of the sodium cholate compound is as follows:

5. The hydrogen peroxide gel according to any one of claims 1 to 3, It is characterized in that The inorganic cross-linking agent includes one or more of calcium nitrate, calcium chloride, magnesium sulfate, strontium acetate, strontium chloride, strontium nitrate, magnesium chloride, magnesium nitrate, magnesium phosphate, calcium hydrogen phosphate, and calcium dihydrogen phosphate.

6. A method for preparing the hydrogen peroxide gel according to any one of claims 1 to 5, It is characterized in that include: The hydrogen peroxide aqueous solution, the gelling agent and the inorganic cross-linking agent are uniformly mixed according to mass percentage, and then the temperature is raised and allowed to stand to form a gel, thereby obtaining the hydrogen peroxide gel.

7. The method for preparing the hydrogen peroxide gel according to claim 6, It is characterized in that The preparation method comprises: S1. Mixing part of the aqueous hydrogen peroxide solution and the dexamethasone compound and stirring evenly; S2, mixing the remaining aqueous hydrogen peroxide solution with the inorganic crosslinking agent and the stabilizer and stirring evenly; S3. At low temperature, the solution obtained in step S1 is mixed with the solution obtained in step S2, and then the temperature is raised and allowed to stand to form a gel to obtain hydrogen peroxide gel, which is stored at low temperature.

8. The method for preparing the hydrogen peroxide gel according to claim 6, It is characterized in that The preparation method comprises: S1, mixing the aqueous hydrogen peroxide solution and the sodium cholate compound and stirring them uniformly to obtain a viscous hydrogen peroxide sol; S2. Add an inorganic crosslinking agent to the hydrogen peroxide sol, stir until the crosslinking agent is completely dispersed or dissolved, then add a stabilizer, stir until the mixture is uniform, and let stand at room temperature to obtain a hydrogen peroxide gel, which is stored at low temperature.

9. The method for preparing the hydrogen peroxide gel according to claim 7, It is characterized in that The amount of the hydrogen peroxide solution in step S1 is 30-70% of the total amount; And / or, the temperature range of the low-temperature mixing is -40 to -10°C; the temperature of the static gelling is 0 to 30°C; the temperature of the low-temperature storage is -10 to 5°C; In steps S1 and S2, the mixing and stirring rate is 500-2500 r / min, and the time is 0.1-5 h; steps S1 and S2 are both carried out at normal temperature and pressure.

10. The method for preparing the hydrogen peroxide gel according to claim 9, It is characterized in that The amount of the aqueous hydrogen peroxide solution in step S1 is 40-60% of the total amount.

11. The method for preparing the hydrogen peroxide gel according to claim 8, It is characterized in that In steps S1 and S2, the mixing and stirring rate is 500 to 2500 r / min, and the time is 0.5 to 5 h; And / or, steps S1 and S2 are both carried out at room temperature and pressure; the low-temperature storage temperature is -10 to 5°C.

Images