Auxiliary material composition for improving the warming yang property of Radix Rehmanniae Preparata and a processing method of Radix Rehmanniae Preparata

Abstract

The invention discloses an auxiliary material composition for improving the warming and yang properties of Radix Rehmanniae Preparata and a method for preparing Radix Rehmanniae Preparata, belonging to the technical field of traditional Chinese medicine preparation, the auxiliary material composition includes 5-25g of dried orange peel, 5-25g of Chinese yam, 5-25g of Atractylodes macrocephala, 5-25g of Poria cocos and 5-25g of Cornus officinalis; the invention also provides a method for preparing Radix Rehmanniae Preparata using the auxiliary material composition. The invention provides a method for increasing the warming and dry properties of Radix Rehmanniae Preparata using non-toxic Chinese medicines such as dried orange peel, Chinese yam, Atractylodes macrocephala, Poria cocos and Cornus officinalis as auxiliary materials, and experiments have shown that the quality of Radix Rehmanniae Preparata slices is stable after the preparation of warming and dry medicinal juice, and the active ingredient types are richer than those of traditional wine-stewed Radix Rehmanniae Preparata and raw Radix Rehmanniae; and the warming and dry properties of Radix Rehmanniae Preparata after preparation are significantly increased, and the therapeutic effect on anemic patients is more significant, which expands the scope of clinical application and meets the daily health care needs of more people for the therapeutic efficacy of Radix Rehmanniae Preparata. Therefore, the preparation method provided by the invention is suitable for industrial production.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine processing, in particular to an auxiliary material composition for improving the warming yang property of Radix Rehmanniae Preparata and a processing method of Radix Rehmanniae Preparata. Background Art

[0002] Rehmannia glutinosa is made from the tubers of Rehmannia glutinosa Libosch, a plant of the Scrophulariaceae family, which are steamed or stewed with wine. The earliest processing method was recorded in Leigong Paozhi Lun during the Southern and Northern Dynasties: "When raw Rehmannia glutinosa is peeled, steam it in a porcelain pot on a willow wood steamer, let it rest until the air stops, mix it with wine and steam it again, and then take it out to dry." Rehmannia glutinosa was first recorded as a drug name in Bencao Tujing: "The roots are collected in February and August, steamed for three or two days, and dried in the sun. This is called Rehmannia glutinosa." Zhang Yuansu, a physician in the Jin and Yuan Dynasties, first used Rehmannia glutinosa as a drug name and discussed its functions in Yixue Qiyuan. After processing, the nature of Rehmannia glutinosa changes from cold to warm, the taste changes from bitter to sweet, and the effects change from clearing heat and cooling blood, nourishing yin and promoting body fluid to nourishing blood and yin, replenishing essence and filling marrow. It is used for yin deficiency and blood deficiency, weakness of waist and knees, fatigue cough and bone steaming, spermatorrhea, metrorrhagia, and irregular menstruation. Modern pharmacological research also shows that in addition to nourishing blood and yin, replenishing essence and filling marrow, cooked rehmannia root also has good antioxidant, anti-aging, anti-mutation, tumor inhibition, immunity enhancement and hematopoietic effects. It can be used clinically for the recovery period of cerebral infarction, traumatic optic atrophy, hypertension, Parkinson's disease, etc. With the deepening of pharmacological research, cooked rehmannia root is becoming more and more popular.

[0003] Although Rehmannia glutinosa is a good tonic with a wide range of effects, it is thick and strong in taste, which is easy to make the stomach greasy and produce phlegm. It is not suitable for patients with qi stagnation, phlegm, dampness, fullness in the middle, and loose stools. At present, it is mainly steamed with wine. Rehmannia glutinosa is warm in nature and mainly replenishes yin and blood. It can disperse with the power of wine, play a role in promoting the potency of the medicine, unblocking blood vessels, and is more conducive to replenishing blood without being greasy. However, the method of steaming with wine makes it impossible for patients with alcohol allergies to eat it, which limits the scope of clinical use of Rehmannia glutinosa to a certain extent.

[0004] The present invention provides a method for increasing the warming and dryness property of Rehmannia glutinosa by using tangerine peel, yam, atractylodes macrocephala, Poria cocos, cornus officinalis and other non-toxic Chinese medicines for nourishing yin and restraining yang as auxiliary materials according to the principle of traditional Chinese medicine theory that "those who are good at replenishing yang must seek yang from yin", so as to prepare Rehmannia glutinosa with warming yang effect, expand the scope of clinical medication, and can also be used for patients with qi stagnation and excessive phlegm, dampness and fullness in the middle, poor appetite and loose stools, and those who are allergic to alcohol, thereby meeting people's daily health care needs. Summary of the invention

[0005] The purpose of the present invention is to provide an auxiliary material composition for improving the warming and yang property of Rehmannia glutinosa and a processing method of Rehmannia glutinosa, so as to solve the problems existing in the above-mentioned prior art. The present invention provides a method for processing Rehmannia glutinosa by using the auxiliary material composition. After processing by the method, the quality of Rehmannia glutinosa slices is stable, and the types of active ingredients are richer than those of traditional wine-stewed Rehmannia glutinosa and raw Rehmannia glutinosa; and the warming and drying property of Rehmannia glutinosa after processing is significantly increased, and the therapeutic effect on anemia patients is more significant, which expands the scope of clinical application, and proves that the processing method is suitable for industrial production.

[0006] To achieve the above object, the present invention provides the following solutions:

[0007] The present invention provides an auxiliary material composition for improving the warming yang property of Radix Rehmanniae Preparata, wherein the auxiliary material composition comprises the following components by weight:

[0008] Tangerine peel 5-25g, yam 5-25g, Atractylodes macrocephala 5-25g, Poria 5-25g and Cornus officinalis 5-25g.

[0009] The present invention also provides a method for preparing Radix Rehmanniae Preparata using the auxiliary material composition, comprising the following steps:

[0010] Weigh a specified amount of auxiliary material combination, soak in water, and boil to obtain medicinal juice;

[0011] Add the obtained medicinal juice to raw Rehmannia root, soak, steam and dry.

[0012] Furthermore, the amount of water used for soaking is 10-50 times the volume of the auxiliary material composition; and the soaking time is 1-5 hours.

[0013] Furthermore, the decoction is performed 2-3 times, and each decoction lasts 1-3 hours.

[0014] Furthermore, the amount of the medicinal juice added is 1-5 times the volume of the raw Rehmannia root; and the soaking time is 4-20 hours.

[0015] Furthermore, the steaming time is 4-12 hours; the drying condition is 40-70° C. for 6-20 hours.

[0016] The invention also provides the Radix Rehmanniae Preparata obtained by the method.

[0017] The present invention also provides the use of the above-mentioned Radix Rehmanniae Preparata in preparing a blood-enriching product.

[0018] Furthermore, the product comprises a medicine.

[0019] The present invention discloses the following technical effects:

[0020] In view of the inadequacy of Rehmannia glutinosa in clinical application, the present invention provides a method for increasing the warming and dryness of Rehmannia glutinosa by using non-toxic Chinese medicines such as dried tangerine peel, Chinese yam, white atractylodes, Poria cocos and cornus officinalis as auxiliary materials according to the principle of "those who are good at tonifying yang must seek yang in yin", and processing Rehmannia glutinosa by the method of seeking yang in yin. Experiments have shown that the quality of Rehmannia glutinosa slices prepared by the present invention is stable, and the types of active ingredients of Rehmannia glutinosa after processing with warming and dry medicinal juice are richer than those of traditional wine-stewed Rehmannia glutinosa and raw Rehmannia glutinosa. The collected clinical data show that the warming and dryness of Rehmannia glutinosa after processing increases significantly, and the therapeutic effect on anemia patients is more significant, which expands the scope of clinical application and meets the daily health care needs of more people for the therapeutic efficacy of Rehmannia glutinosa. Therefore, the processing method provided by the present invention is suitable for industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 The properties of commercially available raw Rehmannia root, traditional wine-stewed Rehmannia root, and Rehmannia root prepared with warm and dry medicinal juice;

[0023] Figure 2 This is the fingerprint liquid phase diagram of Radix Rehmanniae;

[0024] Figure 3 This is the fingerprint liquid phase diagram of traditional wine-stewed Rehmannia root;

[0025] Figure 4 This is the liquid phase diagram of the fingerprint spectrum of Rehmannia glutinosa after being processed with warm and dry medicinal juice. DETAILED DESCRIPTION

[0026] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0027] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0028] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0029] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0030] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0031] In view of the insufficiency of Rehmannia glutinosa in clinical application, the present invention provides a processing technology that uses tangerine peel, Chinese yam, Atractylodes macrocephala, Poria cocos, Cornus officinalis and other non-toxic Chinese medicines of nourishing yin and astringing yang as auxiliary materials to increase the warm and dry nature of Rehmannia glutinosa, and meets the industrial production. The Rehmannia glutinosa prepared by the method of seeking yang in the yin has expanded the scope of clinical application and met the daily health care needs of more people for the therapeutic efficacy of Rehmannia glutinosa. The present invention has carried out sufficient research and verification such as orthogonal experiments on the parameters of each link of the processing technology of Rehmannia glutinosa for the preparation of non-toxic Chinese medicines of nourishing yin and astringing yang, thereby determining the optimal processing technology. In addition, the proportion of each Chinese medicine material is adjusted in large quantities. It is found in the experiment that if the Chinese medicine proportion is adjusted to 30g of tangerine peel, 30g of Chinese yam, 30g of Atractylodes macrocephala, 30g of Poria cocos, and 30g of Cornus officinalis, the Rehmannia glutinosa prepared is black in character and has high viscosity, which is not convenient for storage and use. The content of Rehmannia glutinosa prepared with 2g of dried tangerine peel, 2g of yam, 2g of Atractylodes macrocephala, 2g of Poria cocos, and 2g of Cornus officinalis was determined and analyzed. It was found that the composition of Rehmannia glutinosa prepared with warm and dry properties was not significantly different from that of traditional wine-stewed Rehmannia glutinosa and commercially available raw Rehmannia glutinosa. After repeated demonstrations, the following specific ratio scheme was finally optimized, and the properties, color and texture of the prepared Rehmannia glutinosa all met the standards. The present invention has proved through 5 batches of laboratory amplification tests that the quality of the prepared Rehmannia glutinosa slices is stable. According to the fingerprint spectrum measurement, the Rehmannia glutinosa prepared with warm and dry medicinal juice has obvious differences from traditional wine-stewed Rehmannia glutinosa and commercially available raw Rehmannia glutinosa, and the collected clinical data show that the warm and dry nature of Rehmannia glutinosa prepared after processing has increased significantly, so the processing method is suitable for industrial production. The specific research is as follows:

[0032] Example 1

[0033] Take 5g of dried tangerine peel, 5g of yam, 5g of atractylodes, 5g of poria, and 5g of cornus officinalis, add 10 times the amount of water, soak in a sealed container for 1 hour, decoct twice, each time for 1 hour, filter, combine the liquid, centrifuge at 5000rpm for 15 minutes, and take the supernatant to prepare warm and dry medicinal juice. Take raw rehmannia, add 1 times the amount of the prepared medicinal juice, soak for 4 hours, steam for 4 hours, take out, cool, dry in an oven at 40°C for 6 hours, take out, and spread to air.

[0034] Example 2

[0035] Take 10g of dried tangerine peel, 10g of yam, 10g of atractylodes, 10g of poria, and 10g of cornus officinalis, add 20 times the amount of water, soak in a sealed container for 2h, decoct twice, each time for 1.5h, filter, combine the medicinal liquid, centrifuge at 5000rpm for 15 minutes, and take the supernatant to prepare warm and dry medicinal juice. Take raw rehmannia, add 2 times the amount of the prepared medicinal juice, soak for 8h, steam for 6h, take out, cool, dry in an oven at 50℃ for 8h, take out, and spread to air.

[0036] Example 3

[0037] Take 15g of dried tangerine peel, 15g of yam, 15g of atractylodes, 15g of poria, and 15g of cornus officinalis, add 30 times the amount of water, soak in a closed container for 3 hours, decoct twice, each time for 2 hours, filter, combine the liquid, centrifuge at 5000rpm for 15 minutes, and take the supernatant to prepare warm and dry medicinal juice. Take raw rehmannia, add 3 times the amount of the prepared medicinal juice, soak for 10 hours, steam for 8 hours, take out, cool, dry in an oven at 55°C for 10 hours, take out, and spread to air.

[0038] Example 4

[0039] Take 20g of dried tangerine peel, 20g of yam, 20g of atractylodes, 20g of poria, and 20g of cornus officinalis, add 40 times the amount of water, soak in a closed container for 4 hours, decoct twice, each time for 2.5 hours, filter, combine the medicinal liquid, centrifuge at 5000rpm for 15 minutes, and take the supernatant to prepare warm and dry medicinal juice. Take raw rehmannia, add 4 times the amount of the prepared medicinal juice, soak for 14 hours, steam for 10 hours, take out, cool, dry in an oven at 60℃ for 12 hours, take out, and spread to air.

[0040] Example 5

[0041] Take 25g of dried tangerine peel, 25g of yam, 25g of atractylodes, 25g of poria, and 25g of cornus officinalis, add 50 times the amount of water, soak in a closed container for 5 hours, decoct twice, each time for 3 hours, filter, combine the medicinal liquid, centrifuge at 5000rpm for 15 minutes, and take the supernatant to prepare warm and dry medicinal juice. Take raw rehmannia, add 5 times the amount of the prepared medicinal juice, soak for 20 hours, steam for 12 hours, take out, cool, dry in an oven at 70℃ for 20 hours, take out, and spread to air.

[0042] Comparative Example 1

[0043] The traditional method of preparing Rehmannia root stewed with wine is as follows: (1) Wash the Rehmannia root thoroughly, add 1 / 2 of the rice wine in a scientific proportion to mix, put the prepared Rehmannia root and rice wine into a stewing pot, and seal it; (2) Stew it in water for 24 hours, cut it into thick slices after the stewing, and dry it; (3) After drying, the Rehmannia root slices are obtained.

[0044] Figure 1 The property diagrams of commercially available raw Rehmannia root, traditional wine-stewed Rehmannia root, and Rehmannia root prepared with the warm and dry medicinal juice of Example 1 (warm and dry Rehmannia root).

[0045] Effect verification

[0046] 1. Liquid chromatography was used to detect the differences in fingerprint components of commercially available raw Rehmannia root, traditional wine-stewed Rehmannia root, and Rehmannia root prepared by warm and dry medicinal juice. The determination conditions were as follows: chromatographic column: Agilent C18 (5μm, 250mm×4.6mm); mobile phase: 0.1% phosphoric acid aqueous solution: methanol, gradient elution according to Table 1; column temperature: 30℃; flow rate: 1mL·min -1 ; Detection wavelength: 332nm; Injection volume: 10μL, tested Figure 2-Figure 4 The results showed that the ingredients of the warm-drying Rehmannia root prepared in Example 1 were significantly different from those of the traditional wine-stewed Rehmannia root and the commercially available raw Rehmannia root, and the types of active ingredients were richer.

[0047] Table 1 Elution gradient

[0048]

[0049] 2. Clinical practice of warm and dry Rehmannia root:

[0050] Materials and Methods

[0051] 1 General Information

[0052] A total of 90 anemia patients who received Rehmannia glutinosa drug treatment at Shenzhen Baoan Pure Traditional Chinese Medicine Hospital from May 2019 to May 2020 were selected as research subjects. According to TCM syndrome differentiation, the 90 patients were divided into two groups, with 45 cases in each group. In the control group, there were 16 males and 29 females, aged 19 to 69 years old, with an average age of (42.57±6.38) years old. There were 21 cases of mild anemia, 21 cases of moderate anemia, and 3 cases of severe anemia. The TCM diagnosis of blood deficiency syndrome, blood deficiency, sallow complexion, dizziness and palpitations, and TCM diagnosis of spleen and stomach weakness, fullness and phlegm, and poor appetite and loose stools. In the observation group, there were 19 males and 26 females, aged 20 to 65 years old, with an average age of (42.33±7.01) years old. There were 22 cases of mild anemia, 20 cases of moderate anemia, and 3 cases of severe anemia. The TCM diagnosis of blood deficiency syndrome, blood deficiency, sallow complexion, dizziness and palpitations, and TCM diagnosis of spleen and stomach weakness, fullness and phlegm, and poor appetite and loose stools. There was no significant difference in gender, age, and degree of anemia between the two groups (P>0.05), and they were comparable. This study was approved by the Medical Ethics Committee. Inclusion criteria: (1) met the diagnostic criteria for anemia; (2) patients aged ≥18 years; (3) no history of mental illness; (4) patients knew and signed the informed consent. Exclusion criteria: (1) pregnant or lactating women; (2) patients allergic to the study drugs; (3) patients with other blood diseases.

[0053] 2 Methods

[0054] The control group was treated with Rehmannia glutinosa prepared by traditional wine stewing, and the preparation method was as follows: (1) Wash the Rehmannia glutinosa thoroughly, add 1 / 2 of the scientific ratio of yellow wine for preparation, put the prepared Rehmannia glutinosa and yellow wine into a stewing pot together, and seal it; (2) Stew it in water for 24 hours, cut it into thick slices after the end, and dry it; (3) After drying, get Rehmannia glutinosa slices, take 15g and boil it, control the concentration of 0.188g / L, and take a dosage of 3.75g / kg. The observation group was treated with Rehmannia glutinosa prepared by the preparation method of Example 1 with warm and dry properties, and the method was as follows: (1) Take 15g of Rehmannia glutinosa prepared by warm and dry properties and boil it, control the concentration of 0.188g / L, and take a dosage of 3.75g / kg. Both groups were treated once / d, and the course of treatment was 4 weeks.

[0055] 3 Observation items

[0056] Before and after treatment, 3 mL of fasting venous blood was drawn from the patients, and the changes in the levels of red blood cells (RBC), white blood cells (WBC), and hemoglobin (HB) were measured by a blood cell analyzer, and the changes in the levels of erythropoietin (EPO) were measured by an enzyme labeled analyzer. The occurrence of adverse reactions during the treatment was observed and recorded.

[0057] 4. Criteria for determining efficacy

[0058] ① Significantly effective: anemia symptoms basically disappeared, and the results of routine blood test indicators showed recovery to normal; ② Effective: anemia symptoms were significantly improved, and the results of routine blood test indicators showed improvement; ③ Ineffective: anemia symptoms did not improve or even worsened, and the results of routine blood test indicators showed no change.

[0059] 5 Statistical methods

[0060] SPSS 21.0 software was used for analysis, and the quantitative data were expressed as (x - ±s) and t test were used. Count data were expressed as n(%) and χ 2 The rank sum test was used for rank data, and P < 0.05 was considered statistically significant.

[0061] 6 Results

[0062] 6.1 Comparison of blood routine indicators

[0063] After treatment, the levels of blood routine indicators RBC, WBC, HB, and EPO in the two groups were significantly improved compared with those before treatment (P < 0.05), and the levels of RBC, WBC, HB, and EPO in the observation group were higher than those in the control group (P < 0.05), as shown in Table 2.

[0064] Table 2 Comparison of blood routine indicators before and after treatment between the two groups (x - ±s, n=45)

[0065]

[0066] Note: Compared with before treatment, ▲P<0.05, compared with the control group after treatment, ●P<0.05.

[0067] 6.2 Comparison of therapeutic effects between the two groups The total effective rate of the observation group was higher than that of the control group (P < 0.05), see Table 3.

[0068] Table 3 Comparison of treatment effects between the two groups [n=45, n (%)]

[0069]

[0070] Note: Compared with the control group, *P<0.05.

[0071] 6.3 Adverse Reactions

[0072] During the treatment, no obvious adverse reactions occurred in both groups.

[0073] 7 Results Analysis

[0074] The results of this study showed that after treatment, the levels of blood routine indicators RBC, WBC, HB, and EPO in the two groups were significantly improved compared with those before treatment (P < 0.05), and the levels of RBC, WBC, HB, and EPO in the observation group after treatment were higher than those in the control group, and the difference was significant (P < 0.05), indicating that both have the effect of nourishing blood, but the prepared Rehmannia glutinosa with warm and dry nature prepared by the present invention is more suitable for the syndromes of blood deficiency diagnosed by traditional Chinese medicine, such as sallow complexion, dizziness and palpitations due to blood deficiency, and spleen and stomach weakness, fullness in the middle and phlegm in traditional Chinese medicine diagnosis. and patients with poor appetite and loose stools, and can effectively improve the number of peripheral blood RBC and WBC, increase EPO levels, improve HB levels, and have a stronger blood-tonifying effect; the total effective rate of the observation group was 93.33% (42 / 45), which was higher than 84.44% (38 / 45) (P < 0.05) in the control group, indicating that the prepared Rehmannia glutinosa with warm and dry properties prepared by the preparation method of the present invention has a better therapeutic effect than the traditional wine-stewed preparation; during the treatment period, no obvious adverse reactions occurred in both groups, indicating that both preparation methods have high safety. In summary, the prepared Rehmannia glutinosa with warm and dry properties prepared by the present invention is suitable for patients with various syndromes of blood deficiency in TCM diagnosis, sallow complexion, dizziness and palpitations due to blood deficiency, and TCM diagnosis of patients with spleen and stomach weakness, fullness in the middle and phlegm, and poor appetite and loose stools, and has a better blood-tonifying effect than the traditional wine-stewed Rehmannia glutinosa, can give full play to the efficacy of Rehmannia glutinosa, has a good therapeutic effect, and is suitable for clinical application.

[0075] 8 Typical Cases

[0076] Case 1: Xu, male, was diagnosed by TCM with weak spleen and stomach, fullness in the middle and phlegm, poor appetite and loose stools. He had been diagnosed with mild anemia for 4 months. He had stomach pain and diarrhea after eating cold food. He was prone to abdominal distension and had good sleep but poor appetite. After taking the warm and dry Rehmannia glutinosa decoction for 4 weeks, his energy improved, his anemia symptoms improved significantly, and the results of blood routine test showed improvement.

[0077] Case 2: Meng, female, felt heavy and tired for 3 months. She was diagnosed by TCM as a patient with weak spleen and stomach, fullness in the middle and phlegm, poor appetite and loose stools. She was diagnosed with moderate anemia 4 months ago, with weakness in the limbs, obvious memory loss, heavy menstruation, shallow sleep, easy awakening, and many dreams. After taking warm and dry Rehmannia glutinosa decoction for 4 weeks, the anemia symptoms were significantly improved, fatigue was significantly improved, sleep was good, and the complexion was ruddy, without recurrence.

[0078] Case 3: Zheng, female, 26 years old, miscarried 2 months ago; Chinese medicine diagnosed the patient with weak spleen and stomach, fullness in the middle and phlegm, and poor appetite and loose stools. She was diagnosed with moderate anemia, and sometimes had backache and weak legs. After 2 years of treatment with Chinese and Western medicine, the effect was not obvious. After taking warm and dry Rehmannia glutinosa decoction for 4 weeks, she was re-examined and had full energy and weight gain.

[0079] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A method for preparing Radix Rehmanniae Preparata using an auxiliary material composition that improves the warming yang property of Radix Rehmanniae Preparata, characterized in that: The following steps are involved: Weigh a specified amount of auxiliary material combination, soak in water, and boil to obtain medicinal juice; Add the obtained medicinal juice to the raw Rehmannia root, soak, steam and dry; The steaming time is 4-12h; The auxiliary material composition is composed of the following components by weight: Tangerine peel 5-25g, Chinese yam 5-25g, Atractylodes macrocephala 5-25g, Poria 5-25g and Cornus officinalis 5-25g; The amount of the medicinal juice added is 1-5 times the volume of the raw Rehmannia root; the soaking time is 4-20 hours; The drying condition is 40-70° C. for 6-20 hours.

2. The method according to claim 1, characterized in that: The amount of water used for the soaking is 10-50 times the volume of the auxiliary material composition; and the soaking time is 1-5 hours.

3. The method according to claim 1, characterized in that The decoction is performed 2-3 times, and each decoction lasts 1-3 hours.

4. The Radix Rehmanniae Preparata obtained by the method according to any one of claims 1 to 3.

5. Use of the Radix Rehmanniae Preparata as claimed in claim 4 in the preparation of blood-enriching medicines.

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