Composition for improving female menopausal symptoms and preparation method

Abstract

The invention discloses a functional food composition for improving haggard face and replenishing qi and blood. The functional food composition comprises the following materials in parts by weight: 2-550 parts of ginseng, 3-500 parts of angelica, 3-550 parts of mulberry, 2-500 parts of raspberry, 2-500 parts of wolfberry, 3-550 parts of cassia seed, 3-550 parts of polygonatum, 2-500 parts of polygonatum, 2-400 parts of sophora japonica flower, 3-550 parts of longan pulp, 2-400 parts of platycodon, 2-550 parts of tangerine peel, 3-550 parts of dandelion, 1-250 parts of rose, 1-550 parts of chrysanthemum procumbens, 2-250 parts of loquat leaf, 2-500 parts of burdock root, 2-250 parts of emblica fruit, 2-250 parts of bamboo leaf, 2-250 parts of dried ginger, and 2-250 parts of donkey-hide gelatin. The invention also discloses a preparation method of a functional food composition for improving haggard appearance and replenishing qi and blood.

Description

Technical Field

[0001] The present invention relates to a composition, in particular to a composition for improving female menopausal symptoms. The present invention also relates to a preparation method of the composition for improving female menopausal symptoms. Background Art

[0002] After age 40, both men and women experience a growing haggardness, most notably darker skin, dull complexion, wrinkles, and rough skin. A person's appearance is their calling card, and the aging changes in their face can be deeply painful. This is especially true for women, who, after their forties and fifties, face the added discomfort of menopause, creating even more unbearable suffering.

[0003] As women age, their physical functions decline, leading to insufficient Qi and blood supply. This leads to functional changes in multiple body systems, which can, to varying degrees, trigger various diseases and symptoms. Qi and blood deficiency manifests as a dull complexion, menstrual irregularities, fatigue, and dizziness. Menopausal women, in addition to menstrual irregularities, may also experience irritability, irritability, dizziness, palpitations, insomnia, forgetfulness, hot flashes, sweating, edema, loose stools, fatigue, a tingling sensation on the skin, joint pain, depression, nervousness, urinary urgency, and vaginal dryness. Menopause presents with a series of symptoms, primarily related to autonomic dysfunction, known medically as "menopausal syndrome" and in Traditional Chinese Medicine as "perimenopause syndromes."

[0004] Although women experience ovarian decline during menopause, menstruation gradually ceases, and fertility ceases, other organs in the body remain functionally stable as long as the body is healthy. The speed of aging is closely related to genetics, immunity, endocrine function, environment, nutrition, and mental health, and varies from person to person. Some people of the same age may be energetic, sharp-minded, and agile, while others may be physically and mentally exhausted and slow to react. This suggests that aging can be slowed.

[0005] Therefore, we need to use traditional Chinese medicine to regulate the five internal organs, replenish qi and blood, regulate human functions, improve physical health, maintain ovarian endocrine function, adjust estrogen levels, thereby delaying skin aging, maintaining skin health, and effectively preventing and treating menopausal syndrome, so that women can go through menopause naturally, smoothly and healthily.

[0006] Currently, menopausal syndrome is often treated with estrogen supplementation or medications with tranquilizing properties. However, these treatments have a suboptimal improvement rate for clinical symptoms, and long-term use can also have toxic side effects. For example, excessive progesterone supplementation alone can increase a patient's risk of breast cancer. Over the past 50 years, the widespread use of hormones in Europe and the United States has led to these regions becoming the world's highest incidence of breast cancer. Therefore, finding safe, effective, and comprehensive medications to treat menopausal syndrome in women remains a crucial challenge for medical researchers.

[0007] Traditional Chinese Medicine (TCM) treats diseases based on syndrome differentiation and has obvious advantages. Clinical medications include ancient prescriptions such as Zuogui Pills, Liuwei Dihuang Pills, Erzhi Pills, Yougui Pills, Erxian Decoction, Xiaoyao Pills, Wumei Pills, Shengmai San, and Guipi Pills. In addition, there are many self-prescribed prescriptions by modern clinicians. However, although these prescriptions each have their own characteristics, they are only specialized in one area, with a relatively narrow scope of application and low versatility. For example, Chinese invention patent document CN102793867B discloses a Chinese medicine composition for treating menopausal hot flashes, which is composed of Platycodon grandiflorum, Licorice root, Rehmannia root, Polygonatum sibiricum, Lycium barbarum, Eclipta prostrata, Ligustrum lucidum fruit, Gardenia jasminoides, Cornus officinalis, Phragmites australis, Adenophora scabra, Paeonia suffruticosa, Pseudostellaria baicalensis, Bupleurum chinense, Patchouli lappa, and Scutellaria baicalensis. It is only used to treat the symptom of menopausal hot flashes and has a relatively limited effect. Summary of the Invention

[0008] The technical problem to be solved by the present invention is to provide a composition for improving menopausal symptoms in women. The composition can be used for women who suffer from qi and blood deficiency, yin blood deficiency, essence and blood deficiency, and poor complexion due to long-term staying up late, mental stress, and excessive fatigue. It can also be used for women before and after perimenopause who have symptoms such as menstrual disorders, neuroendocrine disorders, and other symptoms, such as mood swings, anxiety, hot flashes, night sweats, insomnia, and indigestion.

[0009] To solve the above technical problems, the technical solution of the composition for improving female menopausal symptoms of the present invention is:

[0010] The invention comprises the following materials in parts by weight: 2-550 parts of ginseng, 3-500 parts of angelica, 3-550 parts of mulberry, 2-500 parts of raspberry, 2-500 parts of wolfberry, 3-550 parts of cassia seed, 3-550 parts of polygonatum, 2-500 parts of polygonatum, 2-400 parts of sophora japonica flower, 3-550 parts of longan meat, 2-400 parts of platycodon, 2-550 parts of tangerine peel, 3-550 parts of dandelion, 1-250 parts of rose, 1-550 parts of chrysanthemum procumbens, 2-250 parts of loquat leaf, 2-500 parts of burdock root, 2-250 parts of emblica fruit, 2-250 parts of bamboo leaf, 2-250 parts of dried ginger and 2-250 parts of donkey-hide gelatin.

[0011] In another embodiment, the composition further comprises a pharmaceutically acceptable carrier.

[0012] The present invention also provides a method for preparing granules for improving female menopausal symptoms, the technical solution of which comprises the following steps:

[0013] The first step is to weigh the medicinal materials according to the following weight ratio and clean them;

[0014] 2-35 parts of ginseng, 3-30 parts of angelica, 3-35 parts of mulberry, 2-30 parts of raspberry, 2-30 parts of wolfberry, 3-35 parts of cassia seed, 3-35 parts of polygonatum, 2-30 parts of polygonatum, 2-25 parts of sophora japonica flower, 3-35 parts of longan pulp, 2-25 parts of platycodon, 2-35 parts of tangerine peel, 3-35 parts of dandelion, 1-15 parts of rose, 1-40 parts of chrysanthemum procumbentum, 2-15 parts of loquat leaf, 2-30 parts of burdock root, 2-15 parts of emblica fruit, 2-15 parts of bamboo leaf, 2-15 parts of dried ginger, and 2-15 parts of donkey-hide gelatin.

[0015] The second step is to dry the medicinal materials and grind them into powder;

[0016] The third step is to fully mix the medicinal powder and then sterilize it at high temperature;

[0017] The fourth step is to add excipients, form granules and form particles;

[0018] The fifth step is to sterilize again at high temperature.

[0019] The present invention also provides a method for preparing a paste prescription for improving female menopausal symptoms, the technical solution of which comprises the following steps:

[0020] The first step is to weigh the medicinal materials according to the following weight ratio, clean them, decoct them, remove the residue, and take the concentrated juice;

[0021] 15-550 parts of ginseng, 15-500 parts of angelica, 15-550 parts of mulberry, 10-500 parts of raspberry, 12-500 parts of wolfberry, 20-550 parts of cassia seed, 20-550 parts of polygonatum, 10-500 parts of polygonatum, 10-400 parts of sophora japonica flower, 15-550 parts of longan pulp, 6-400 parts of platycodon, 10-550 parts of tangerine peel, 15-550 parts of dandelion, 6-250 parts of rose, 6-550 parts of chrysanthemum procumbentum, 7-250 parts of loquat leaf, 10-500 parts of burdock root, 6-250 parts of emblica fruit, 6-250 parts of bamboo leaf, 8-250 parts of dried ginger, and 7-250 parts of donkey-hide gelatin.

[0022] The second step is to add 200 to 500 parts of honey, melt it and make a paste.

[0023] The effects of each component of the present invention are as follows:

[0024] (1) Ginseng (Renshen):

[0025] It is the dried root of Panax ginseng CAMey., a plant of the Araliaceae family.

[0026] Chemical composition: This product contains a variety of ginsenosides, volatile oils, amino acids, trace elements, organic acids, sugars, vitamins and other ingredients.

[0027] Pharmacological Actions: Ginseng has anti-shock properties. Ginseng injection is particularly effective for patients with hemorrhagic shock and acute toxic shock, compared to shock caused by other causes. It can significantly increase cardiac amplitude and heart rate, and its cardiotonic effects are even more pronounced in patients with heart failure. It can stimulate the pituitary-adrenal cortex system, improving stress response. It enhances both the excitatory and inhibitory processes of higher nervous system activity, increasing the flexibility of neural activity and improving mental function. It has anti-fatigue effects, promotes protein, RNA, and DNA synthesis, promotes hematopoietic function, and regulates cholesterol metabolism. It can enhance immune function, strengthen gonadal function, and have gonadotropin-like effects. It can also lower blood sugar. Ginseng also has various other effects, including anti-inflammatory, anti-allergic, anti-diuretic, and anti-tumor. Ginseng's pharmacological activities often exhibit dual effects depending on the body's functional state.

[0028] (2) Danggui:

[0029] It is the root of Angelica sinensis (Oliv) Diels., a plant of the Umbelliferae family.

[0030] Chemical composition: Angelica contains neutral oil components such as β-pinene, α-pinene, and camphene. It also contains acidic oil components such as p-methylbenzyl alcohol and 5-methoxy-2,3-xylenol, organic acids, sugars, vitamins, and amino acids.

[0031] Pharmacological Actions: Angelica sinensis volatile oil can counteract the uterine excitatory effects of epinephrine, vasopressin, or histamine. Water- or alcohol-soluble non-volatile substances in Angelica sinensis have an excitatory effect on the isolated uterus, enhancing uterine contractions. Large or repeated doses can even cause tonic contractions. The alcohol-soluble substance has a stronger effect than the water-soluble substance. In isolated toad heart perfusion experiments, a decoction containing this product's volatile oil significantly inhibited the amplitude and rate of contraction. Angelica sinensis extract significantly dilated isolated guinea pig coronary arteries and increased coronary blood flow. Intravenous administration of this product in anesthetized dogs showed no significant change in heart rate, decreased coronary resistance and total peripheral resistance, significantly increased coronary blood flow, significantly decreased myocardial oxygen consumption, and showed an upward trend in cardiac output and stroke index. Angelica sinensis neutral oil also has a significant protective effect against experimental myocardial ischemia. Angelica sinensis and its sodium ferulate have significant antithrombotic effects. Oral administration of an aqueous Angelica sinensis extract to mice significantly promoted hemoglobin and erythrocyte production.

[0032] (3) Mulberry:

[0033] It is the fruit cluster of Morus alba L., a plant of the Moraceae family.

[0034] Chemical composition: This product contains sugar, tannic acid, malic acid, vitamins B1, B2, C, carotene, protein, rutin and other components.

[0035] Pharmacological effects: Mulberry has a moderate effect on promoting lymphocyte transformation; it can promote T cell maturation, thereby restoring the function of aging T cells; it has a promoting effect on the humoral immune function of young mice; it has a promoting effect on the growth of granulocytes; it reduces the activity of Na+-K+-ATPase in the red blood cell membrane, which may be one of its yin-nourishing effects; it also has the effect of preventing leukopenia caused by cyclophosphamide.

[0036] (4) Raspberry (Fupenzi):

[0037] It is the immature fruit of Rubus chingii Hu, a plant of the Rosaceae family.

[0038] Chemical composition: Raspberry contains organic acids, sugars and a small amount of vitamin C. The fruit also contains triterpenes, raspberry acid, ellagic acid and β-sitosterol.

[0039] Pharmacological effects: All four extracts of raspberry: the water extract, alcohol extract, crude polysaccharide, and n-butanol fraction, all significantly promote lymphocyte proliferation. Using a D-galactose aging model in mice, raspberry was found to significantly shorten swimming latency and reduce brain monoamine oxidase B activity, suggesting that raspberry improves learning and memory and delays aging. Furthermore, it has a scavenging effect on superoxide anion free radicals, with the corresponding concentration (IC50) for 50% inhibition of superoxide free radicals produced by the pyrogallol autooxidation system being 0.0467 mg / ml. Raspberry has inhibitory effects on Staphylococcus aureus and Vibrio cholerae. It also has estrogenic and antimutagenic properties.

[0040] (5) Gouqizi:

[0041] It is the mature fruit of Lycium barbarum I., a plant of the Solanaceae family.

[0042] Chemical composition: This product contains betaine, polysaccharides, crude fat, crude protein, thiamine, riboflavin, niacin, carotene, ascorbic acid, niacin, β-sitosterol, linoleic acid, trace elements and amino acids.

[0043] Pharmacological effects: Lycium barbarum has a stimulating and immunomodulating effect; it can increase blood testosterone levels, strengthening the body; it promotes hematopoiesis; and it significantly increases white blood cell counts in healthy individuals. It also has anti-aging, anti-genetic damage, anti-mutation, anti-tumor, lipid-lowering, liver-protecting, anti-fatty liver, blood sugar-lowering, blood pressure-lowering, heart-inhibiting, and intestinal-stimulating effects, including cholinergic effects. It has also been shown to enhance mice's tolerance to hypoxia and prolong their swimming time.

[0044] (6) Cassia seed (Juemingzi):

[0045] It is the dried mature seeds of Cassia obtusifolia L. or Cassia tora L. of the leguminous plant.

[0046] Chemical composition: This product mainly contains anthraquinones such as rhein, emodin, aloe-emodin, cassia seed, auranthus seed, and cassia seed. It also contains naphthopyrrolones such as cassia glycoside, cassia ketone, and cassia lactone. In addition, it also contains sterols, fatty acids, sugars, proteins, etc.

[0047] Pharmacological effects: The water extract, alcohol water extract and ethanol extract of this product all have the effect of lowering blood pressure; this product has the effect of lowering plasma total cholesterol and triglycerides; its injection can cause thymus atrophy in mice and enhance the phagocytic function of phagocytes; the anthraquinones it contains have a mild laxative effect; after removing the alcohol from its alcohol extract, it has inhibitory effects on Staphylococcus aureus, Staphylococcus albus, Staphylococcus aurantiacus, Corynebacterium diphtheriae, Bacillus megaterium, Salmonella typhi, Salmonella paratyphi, Salmonella paratyphi B and Escherichia coli; its water extract has varying degrees of inhibitory effect on skin fungi.

[0048] (7) Huangjing:

[0049] It is the rhizome of Polygonatum sibiricum Red., P.kingianum Coll.etHemsl. or P.cyrtonema Hua, all plants of the Liliaceae family.

[0050] Chemical composition: This product contains Polygonatum sibiricum polysaccharides, oligosaccharides, mucus, starch and various amino acids (Polygonatum sibiricum also contains various anthraquinone compounds) and other ingredients.

[0051] Pharmacological effects: Polygonatum sibiricum can enhance the body's immune function and promote the synthesis of DNA, RNA and protein, and promote lymphocyte transformation; it has significant anti-tuberculosis effects; it has inhibitory effects on a variety of pathogenic fungi; it also has inhibitory effects on Salmonella typhi and Staphylococcus aureus; it increases coronary flow and lowers blood pressure, and can lower blood lipids and reduce the degree of coronary atherosclerosis; it has a significant inhibitory effect on high blood sugar caused by adrenaline; it also has the effect of inhibiting the adrenal cortex and anti-aging effects.

[0052] (8) Yuzhu:

[0053] It is the rhizome of Polygonatum odoratum (Mll.) Druce, a plant of the Liliaceae family.

[0054] Chemical composition: This product contains steroidal saponins (convalerian glycosides, lily of the valley glycosides, etc.), flavonoids and their glycosides (quercetin glycosides, etc.), trace elements, amino acids and other nitrogen-containing compounds, as well as mucilage, chelidonic acid, and vitamin A-like substances.

[0055] Pharmacological Actions: This product promotes antibody production in experimental animals, increases the phagocytic percentage and index of macrophages, promotes interferon synthesis, inhibits the growth of Mycobacterium tuberculosis, lowers blood sugar and lipids, alleviates the formation of atherosclerotic plaques, dilates peripheral and coronary arteries, prolongs hypoxia tolerance, strengthens the heart, has antioxidant and anti-aging effects. It also has effects similar to adrenocortical hormones. The pharmacological effects of closadin in the rhizome are similar to those of strophanthus scutellariae, with cardiotonic, diuretic, and sedative effects.

[0056] (9) Sophora japonica (Huaihua):

[0057] It is the dried buds and flowers of Sophora japonica L., a plant of the Leguminosae family.

[0058] Chemical composition: This product is rich in rutin, quercetin, tannin, etc.

[0059] Pharmacological Action: Sophora japonica flower water extract significantly shortens bleeding and clotting times, and its clotting-promoting effect is even stronger after charcoalization. Its decoction reduces myocardial oxygen consumption and protects cardiac function. It also exhibits varying degrees of inhibitory activity against dermatophytes such as Trichophyton violaceum, Trichophyton sylvatica, Microsporum audouinensis, Microsporum capsularis, and Nocardia asteroides. Sophora japonica flower extract exhibits strong inhibitory activity against 15-hydroxyprostaglandin dehydrogenase, with an inhibition rate of 60.6% and an activity of 34.4%. Inhibition of 15-hydroxyprostaglandin dehydrogenase prolongs the diuretic effect of prostaglandin E2 (PGE2). Sophora japonica flower extract stimulates the intestinal mucosa in rabbits, producing exudate.

[0060] (10) Longyanrou:

[0061] It is the aril of the evergreen tree Dimocarpus longan Lour. of the Sapindaceae family.

[0062] Chemical composition: Longan pulp contains water-soluble substances, insoluble substances, and ash. Soluble substances include glucose, protein, fat, and vitamins B1, B2, P, and C.

[0063] Pharmacological Action: Intraperitoneal administration of longan extract to female rats reduced plasma levels of prolactin, estradiol, and testosterone, while increasing levels of progesterone and follicle-stimulating hormone (FSH). This suggests that longan extract affects the endocrine function of the pituitary-gonadal axis in rats. In Escherichia coli experiments, aqueous longan extract showed no mutagenic toxicity and antagonized the mutagenic effects of mitomycin C. Longan extract inhibited lipid peroxide production in mouse liver homogenates in vitro. Oral administration of the extract to mice increased blood glutathione peroxidase activity and T cell detection rates in the thymus and lymphoid tissues. Subcutaneous administration of longan extract to mice produced anxiolytic effects and analgesic effects in the righting test. The active ingredient is adenosine. Longan extract and gecko extracts promote growth and enhance physical fitness. They significantly prolonged the survival time of mice in hypoxia at normal pressure and reduced mortality in hypothermia.

[0064] (11) Platycodon grandiflorum (Jiegeng):

[0065] It is the root of Platycodon grandiflorum (Jacq.) A.DC., a plant of the Campanulaceae family.

[0066] Chemical Composition: This product contains a variety of saponins, primarily platycodin. The sapogenins produced by complete hydrolysis of mixed saponins include platycodinin, polygalic acid, and a small amount of platycodonic acid. It also contains inulin and phytosterols.

[0067] Pharmacological Actions: Platycodon saponins directly stimulate the oral, throat, and gastric mucosa, reflexively increasing bronchial mucosal hypersecretion, thereby diluting sputum and facilitating its excretion. Platycodon has antitussive properties and enhances anti-inflammatory and immune effects, with anti-inflammatory potency similar to that of aspirin. Its aqueous extract enhances the phagocytic function of macrophages, the bactericidal capacity of neutrophils, and increases lysozyme activity, preventing stress ulcers. Crude Platycodon saponins have sedative, analgesic, and antipyretic effects, as well as lowering blood sugar and cholesterol and relaxing smooth muscle. Platycodon saponins have a strong hemolytic effect, but oral administration leads to their breakdown in the digestive tract, rendering them ineffective.

[0068] (12) Orange peel / Chenpi (Jupi / chenpi):

[0069] It is the mature dried peel of Citrus reticulata Blanco and its cultivated varieties.

[0070] Chemical composition: Tangerine peel contains nobiletin, hesperidin, neohesperidin, hesperetin, hydroxyforin, flavonoids, etc. The volatile oil content of tangerine peel is 1.5% to 2.0%, and the volatile oil content of tangerine peel is 1.2% to 3.2%, and its components include α-thujene and limonene.

[0071] Pharmacological effects: The decoction of this product has a direct inhibitory effect on the isolated intestine of rabbits and mice, and the stomach and intestinal motility of anesthetized rabbits and dogs; a small amount of decoction can enhance cardiac contractility, increase cardiac output, dilate coronary arteries, and increase coronary flow, while a large dose can inhibit the heart; the water-soluble total alkaloids in tangerine peel have the effect of increasing blood pressure; tangerine peel extract has the effect of scavenging oxygen free radicals and resisting lipid peroxidation; the decoction of fresh tangerine peel has the effect of dilating the trachea; the volatile oil has a stimulating and expectorant effect, and the main active ingredient is limonene; the decoction of tangerine peel has an inhibitory effect on the isolated mouse uterus, and high concentrations make it completely relaxed. Intravenous injection of the decoction can cause the uterus in anesthetized rabbits to have a tonic contraction; it has choleretic and serum cholesterol-lowering effects.

[0072] (13) Dandelion

[0073] It is the dried whole herb of Taraxacum mongolicum Hand.-Mazz, Taraxacum sinicum Kitag. or several plants of the same genus in the Asteraceae family.

[0074] Chemical composition: This product contains dandelion sterols, dandelion, dandelion bitters, inositol and lettuce alcohol, dandelion sorbitol, caffeic acid and resin, etc.

[0075] Pharmacological Actions: Decoctions or infusions of this herb have strong inhibitory effects against Staphylococcus aureus, hemolytic Streptococci, and Catarrhalis. They also have some inhibitory effects against Pneumococcus, Meningococcus, Corynebacterium diphtheriae, Shigella flexneri, Pseudomonas aeruginosa, and Leptospira. It exhibits synergistic effects with TMP (sulfonamide potentiator). It also has choleretic, hepatoprotective, anti-endotoxin, and diuretic effects, with its choleretic effect being more pronounced than that of Artemisia capillaris decoction. An aqueous extract of the aerial parts of dandelion can activate macrophages and exhibit anti-tumor effects. In vitro studies suggest that this herb can stimulate the body's immune function. Clinical studies have reported that dandelion can also be used for other conditions. For example, combining dandelion with hawthorn, mistletoe, astragalus, and schisandra chinensis can treat hyperlipidemia. A dandelion decoction can lower blood glucose and lipid levels in diabetic mice. Combining it with flavonoids from Potentilla truncatula has even more potent hypoglycemic and lipid-lowering effects.

[0076] (14) Rose (Meiguihua):

[0077] It is the dried flower buds of Rosa rugosa Thunb., a plant of the Rosaceae family.

[0078] Chemical Composition: This product contains volatile oils. The main components of the oil are citronellol, geraniol, nerol, eugenol, and phenylethyl alcohol. It also contains quercetin, tannins, fatty oils, and organic acids.

[0079] Pharmacological Actions: Rose oil promotes bile secretion in rats; rose flowers have a protective effect against myocardial ischemia in experimental animals. Topical application of rose total extract increases blood flow in the mesenteric arterioles of mice and accelerates recovery from adrenaline-induced microcirculatory impairment. Rose tannin E induces platelet aggregation in rabbits and humans and may be an ADP receptor agonist on rabbit platelets. Rose extract has antiviral effects against human immunodeficiency virus (HIV), leukemia virus, and T-cell leukemia virus. Its long-pedunculated aristolochic acid and neosonadin I inhibit reverse transcriptase in cells infected with mouse leukemia virus. Rose has antioxidant properties and scavenges DPPH free radicals. Rose juice induces differentiation of leukemia HL-60 cells and inhibits the growth of various tumor cell lines, but has minimal toxicity to normal human cells.

[0080] (15) Pingwojusanqi:

[0081] Gynura procumbens (Lour.) Merr is an annual herb of the genus Gynura in the Asteraceae family.

[0082] Chemical composition: This product contains flavonoids, phenolic acids, alkaloids, terpenes, phenylpropanoids, fatty acids, steroids and their glycosides, etc.

[0083] Pharmacological Actions: An aqueous extract of Glehnia littoralis can effectively reduce serum lactate dehydrogenase and creatine phosphokinase levels, effectively lowering blood pressure in spontaneously hypertensive rats. It can effectively inhibit HMGCR activity and protein expression, further reducing cholesterol synthesis in the body without any toxic side effects, thereby lowering blood sugar and lipid levels. It can also increase muscle glucose levels and alleviate the symptoms of streptozotocin-induced type 2 diabetes. Studies in rats have shown that chlorogenic acid can significantly reduce blood triglyceride levels. Chlorogenic acid, the main active product of Glehnia littoralis alcohol extract, can regulate lipid metabolism-related genes through MAPK / SPEBP-1c and independent pathways, demonstrating significant efficacy in treating alcohol-induced fatty liver disease. Glehnia littoralis not only lowers blood sugar in diabetic rats but also has a significant therapeutic effect on their complications (infertility). After one week of administration of an aqueous extract of Glehnia littoralis, diabetic rats showed significant improvements in spermatogenesis, sperm quality, libido, and androgen levels (luteinizing hormone, follicle-stimulating hormone, and testosterone). It also has antioxidant, anti-inflammatory, antibacterial, antimicrobial activity, anticancer, anti-gout, anxiolytic, wound healing, analgesic, antidiarrheal, and antipyretic effects.

[0084] (16) Loquat leaves (Pipaye):

[0085] It is the leaf of Eriobotrya japornica (Thunb.) Lindl., a plant of the Rosaceae family.

[0086] Chemical composition: This product contains volatile oil (mainly nerolidol and farnesol) as well as tartaric acid, ursolic acid, oleanolic acid, amygdalin, tannin, vitamin B, C, sorbitol, etc.

[0087] Pharmacological Actions: This product has antitussive and antiasthmatic effects, but its expectorant effect is weak. Its decoction has inhibitory effects on Staphylococcus aureus in vitro, as well as Staphylococcus albus, Pneumococcus, and Shigella dysenteriae. Its ether-infused extract and the ursolic acid it contains have anti-inflammatory properties. Topical application of an ether-infused extract of loquat leaves has a potent inhibitory effect on carrageenan-induced edema, with an inhibition rate of 52% (2 hours after carrageenan injection). Its active ingredients have been isolated and identified as ursolic acid and 2α-hydroxylinoleic acid methyl ester, the latter of which is comparable to the methyl ester of maslic acid. Ursolic acid in loquat leaves has anti-tumor effects. Furthermore, sesquiterpene glucosides and polyhydroxytriterpene glycosides in the methanol extract of loquat leaves significantly reduce urine sugar in genetically diabetic mice, and the latter also reduces blood sugar in normal mice. The main component, triterpene acids, have anti-inflammatory, hypoglycemic, and antiviral effects.

[0088] (17) Burdock root (Niubanggen):

[0089] It is the root of Arctium lappa L., a plant of the genus Arctium in the Asteraceae family.

[0090] Chemical composition: This product contains chemical components such as thioacetylenes, polyacetylenes, polyphenols, volatile oils, inulin and amino acids.

[0091] Pharmacological Actions: The entire burdock plant contains antimicrobial compounds. Polyacetylenes in burdock root have potent antibacterial and antifungal properties. Burdock root contains polyphenolic compounds such as caffeic acid and chlorogenic acid, which have antimutagenic and anticancer properties. Arctidin and arctigenin can also inhibit the activity of phosphofructoylase in cancer cells. Arctigenin has significant inhibitory activity against skin cancer in mice, lung cancer in rats, and liver cancer, with particularly strong inhibitory activity against leukemia rat models. Burdock oligosaccharides can stimulate insulin secretion, improve peripheral tissue sensitivity to insulin, reduce the body's insulin requirement, and regulate blood sugar levels in diabetic patients. Ingestion of burdock oligosaccharides slows gastric emptying and, through colonic fermentation, produces short-chain fatty acids, which affect the rate and quantity of glucose absorption in the small intestine, lowering fasting blood sugar levels and potentially preventing diabetes. Inulin from burdock root can significantly reduce serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels in rats fed a high-fat diet, and reduce indicators of arteriosclerosis. In addition, it has antioxidant, liver-protecting, anti-aging, anti-fatigue, immune regulation, and growth-promoting effects.

[0092] (18) Yuganzi:

[0093] It is the fruit of Phyllanthus emblica L., a plant of the genus Phyllanthus in the Euphorbiaceae family.

[0094] Chemical composition: The fruit of emblica is rich in phenolic compounds, flavonoids, polysaccharides, terpenoids and sterols, fatty acids, vitamins, proteins and amino acids, trace elements, anthraquinones, alkaloids and other ingredients.

[0095] Pharmacological Actions: Phyllanthus emblica fruit has inhibitory effects against Gram-positive bacteria such as Staphylococcus aureus, Bacillus subtilis, Clostridium perfringens, Salmonella, and Bacillus stearothermophilus; Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Proteus, and Klebsiella pneumoniae; fungi such as Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Aspergillus oryzae; and viruses such as hepatitis B virus (HBV), herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and HIV-1. Both aqueous and alcohol-extracted extracts have demonstrated significant protective effects against acute and chronic liver damage induced by various agents. Studies on in vitro and in vivo models of hyperlipidemia-induced atherosclerosis, a diabetic model, and an oxidative stress-induced renal insufficiency model in aged rats have demonstrated that the protective effects of Phyllanthus emblica on cardiovascular and cerebrovascular health are not solely due to its antioxidant properties, but rather involve a multifaceted and multi-layered regulatory mechanism. Phyllanthus emblica fruit phenolics have lipid-lowering and weight-loss effects and also have a protective effect on the cardiovascular system. Gallic acid contained in emblica fruit juice, water extract, and leaves has a significant inhibitory effect on certain tumor cells, such as BEL-7404, S-180, H-22, and L929, both in vivo and in vitro. Its anti-tumor mechanism is closely related to cell cycle regulation and DNA protection. Emblica fruit modulates the immune system through multiple pathways, enhancing humoral immunity, specific cellular immunity, and nonspecific immunity. Research on this activity primarily relies on emblica fruit juice and water extracts. It also has anti-fatigue, anti-hypoxia, anti-aging, anti-inflammatory, gastroprotective and anti-gastric ulcer properties, as well as metal detoxification and radiation protection.

[0096] (19) Dried ginger:

[0097] It is the dried rhizome of ginger, Zingiber officinale Rosc., a plant of the Zingiberaceae family.

[0098] Chemical composition: Dried ginger contains about 2% volatile oil, the main components of which are zingiberene, phellandrene, kanene, zingiberenone, gingerol, zingerone, borneol, gingerol, citral, etc. It also contains resin, starch, and various amino acids.

[0099] Pharmacological effects: Dry ginger extract enhances isolated cardiac spontaneous activity. Intravenous administration of 0.25g / kg of dry ginger extract to rats resulted in a transient pressor followed by a hypotensive effect, and enhanced atrial spontaneous activity. Oral administration of 1.5ml / kg and 3.0ml / kg of dry ginger ether extract slowed the oxygen consumption of mice and prolonged survival in models of normobaric confinement hypoxia and KCN-induced hypoxia. A methanol extract of ginger lowered serum cholesterol in rabbits fed a cholesterol diet, inhibited increases in the total cholesterol / phospholipid ratio, and alleviated atherosclerotic lesions. Methanol or ether extracts of dry ginger exhibited sedative, analgesic, anti-inflammatory, and antiemetic effects; aqueous extracts or volatile oils significantly prolonged experimental thrombosis in rats; alcohol extracts of dry ginger and their gingerols and zingiberisones exhibited significant molluscicide and anti-schistosomal effects. An alcohol extract of dry ginger significantly increased bile secretion in rat livers, with a duration lasting for 3-4 hours.

[0100] (20) Danzhuye:

[0101] It is the dried stems and leaves of Lophatherum gracile Bronga., a plant of the Poaceae family.

[0102] Chemical composition: This product contains triterpenoids such as arundin, imperataein, taraxacin and steroids such as β-sitosterol, stigmasterol, campesterol, taraxacin etc.

[0103] Pharmacological Actions: The aqueous extract of this product has an antipyretic effect; its diuretic effect is weak, but it increases urinary chloride excretion. Its crude extract has anti-tumor effects; its decoction has inhibitory effects on Staphylococcus aureus and hemolytic Streptococci. It also has the effect of increasing blood sugar. The aqueous extract has an antipyretic effect when administered orally to rats with fever induced by yeast suspension.

[0104] (21) Ejiao:

[0105] It is a rubber block made from the skin of the donkey Equus asinus L., an equine animal, which is bleached, soaked, dehaired and then boiled.

[0106] Chemical composition: Donkey-hide gelatin is mostly composed of collagen, which is hydrolyzed to produce a variety of amino acids, such as lysine, arginine, histidine, cystine, tryptophan, hydroxyproline, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, etc.

[0107] Pharmacological Actions: Bloodletting was used to reduce the hemoglobin and red blood cell levels in dogs, followed by feeding them with donkey-hide gelatin products. Results demonstrated a significant blood-tonifying effect, superior to iron supplements. Blood calcium levels were slightly elevated in those taking donkey-hide gelatin, but clotting time remained unchanged. A rabbit model of chronic nephritis, induced by a modified vassilii method, achieved positive nitrogen balance two weeks after administration, while the control group maintained a negative balance. Donkey-hide gelatin has been shown to stimulate the growth of mononuclear phagocytes in the liver and spleen of mice. It has also been shown to promote lymphocyte transformation in healthy humans. Donkey-hide gelatin, with its high calcium content, can increase calcium intake, effectively alleviating bone calcium loss and calcium salt efflux, osteoporosis, bone hyperplasia, and various fractures caused by calcium deficiency. It also exhibits anti-radiation, hypoxia- and cold-resistance, anti-fatigue, anti-shock, and hemostatic effects.

[0108] The technical effects that can be achieved by the present invention are:

[0109] The present invention selects a product that is both a food and a medicine, harmonizes the five internal organs, nourishes the essence and blood, promotes the six internal organs to innovate, maintains the health of menopausal women, and has the effect of healthy and beautiful complexion. Compared with the current chemotherapeutic drugs, the Chinese medicine composition of the present invention is a natural food and medicine product with significantly reduced adverse reactions and side effects, comprehensive effects, and better drug treatment effects. The food and medicine composition of the present invention contains multiple drug components with numerous targets. Pharmacological experiments have shown that it has significant anti-aging, anti-oxidant free radical, blood circulation and blood stasis activities, effectively solving the root cause of menopausal syndrome, and its therapeutic effect on menopausal syndrome has the effect of treating both the symptoms and the root causes. The present invention has a significant effect on various symptoms of menopause and is suitable for widespread promotion.

[0110] The invention can improve the menopausal symptoms of women, thereby improving the haggard appearance, replenishing qi and blood, and improving the complexion. BRIEF DESCRIPTION OF THE DRAWINGS

[0111] Those skilled in the art will appreciate that the following description is merely illustrative of the principles of the present invention, which can be applied in a variety of ways to achieve many different alternative embodiments. These descriptions are intended only to illustrate the general principles of the teachings of the present invention and are not intended to limit the inventive concepts disclosed herein.

[0112] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the general description above and the detailed description of the drawings that follow, serve to explain the principles of the invention.

[0113] The present invention will be further described in detail below with reference to specific embodiments: DETAILED DESCRIPTION

[0114] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Unless otherwise defined, the technical terms or scientific terms used herein should be the common meanings understood by people with ordinary skills in the field to which the present invention belongs.

[0115] The composition for improving female menopausal symptoms of the present invention comprises the following materials in parts by weight:

[0116] 2-550 parts of ginseng, 3-500 parts of angelica, 3-550 parts of mulberry, 2-500 parts of raspberry, 2-500 parts of wolfberry, 3-550 parts of cassia seed, 3-550 parts of polygonatum, 2-500 parts of polygonatum, 2-400 parts of sophora japonica, 3-550 parts of longan meat, 2-400 parts of platycodon, 2-550 parts of tangerine peel, 3-550 parts of dandelion, 1-250 parts of rose, 1-550 parts of chrysanthemum procumbentum, 2-250 parts of loquat leaf, 2-500 parts of burdock root, 2-250 parts of emblica fruit, 2-250 parts of bamboo leaf, 2-250 parts of dried ginger, and 2-250 parts of donkey-hide gelatin.

[0117] Example 1

[0118] A granule for improving female menopausal symptoms, replenishing qi and blood, and improving complexion, the raw materials of which include:

[0119] 2 parts of ginseng, 3 parts of angelica, 3 parts of mulberry, 2 parts of raspberry, 2 parts of wolfberry, 3 parts of cassia seed, 3 parts of polygonatum, 2 parts of polygonatum, 2 parts of sophora japonica, 3 parts of longan meat, 2 parts of platycodon, 2 parts of tangerine peel, 3 parts of dandelion, 1 part of rose, 1 part of chrysanthemum procumbentum, 2 parts of loquat leaf, 2 parts of burdock root, 2 parts of emblica fruit, 2 parts of bamboo leaf, 2 parts of dried ginger, and 2 parts of donkey-hide gelatin.

[0120] The specific preparation method is as follows:

[0121] 1. Weigh the medicinal materials according to the above weight ratio and wash them clean;

[0122] 2. Dry the medicinal materials and grind them into powder;

[0123] 3. After fully mixing the medicinal powder, sterilize it at a high temperature above 100°C;

[0124] 4. Add excipients, shape and granulate to form fine particles;

[0125] 5. Sterilize again at a high temperature of over 100°C.

[0126] Example 2

[0127] A granule for improving female menopausal symptoms, replenishing qi and blood, and improving complexion, the raw materials of which include:

[0128] Ginseng 9g, angelica 12g, mulberry fruit 15g, raspberry 12g, wolfberry 12g, cassia seed 15g, polygonatum 15g, polygonatum 12g, sophora japonica flower 9g, longan meat 15g, platycodon 9g, tangerine peel 15g, dandelion 15g, rose 6g, chrysanthemum notoginseng 30g, loquat leaf 9g, burdock root 15g, emblica fruit 9g, bamboo leaf 9g, dried ginger 9g, donkey-hide gelatin 9g.

[0129] The specific preparation method is as follows:

[0130] 1. Weigh the medicinal materials according to the above weight ratio and wash them clean;

[0131] 2. Dry the medicinal materials and grind them into powder;

[0132] 3. After fully mixing the medicinal powder, sterilize it at a high temperature above 100°C;

[0133] 4. Add excipients, shape and granulate to form fine particles;

[0134] 5. Sterilize again at a high temperature of over 100°C.

[0135] Example 3

[0136] A granule for improving female menopausal symptoms, replenishing qi and blood, and improving complexion, the raw materials of which include:

[0137] 35 parts of ginseng, 30 parts of angelica, 35 parts of mulberry fruits, 30 parts of raspberry, 30 parts of wolfberry, 35 parts of cassia seeds, 35 parts of polygonatum, 30 parts of polygonatum, 25 parts of sophora japonica, 35 parts of dried longan meat, 25 parts of platycodon, 35 parts of tangerine peel, 35 parts of dandelion, 15 parts of rose, 40 parts of chrysanthemum procumbentum, 15 parts of loquat leaves, 30 parts of burdock roots, 15 parts of emblica fruits, 15 parts of bamboo leaves, 15 parts of dried ginger, and 15 parts of donkey-hide gelatin.

[0138] The specific preparation method is as follows:

[0139] 1. Weigh the medicinal materials according to the above weight ratio and wash them clean;

[0140] 2. Dry the medicinal materials and grind them into powder;

[0141] 3. After fully mixing the medicinal powder, sterilize it at a high temperature above 100°C;

[0142] 4. Add excipients, shape and granulate to form fine particles;

[0143] 5. Sterilize again at a high temperature of over 100°C.

[0144] Example 4

[0145] A paste prescription for improving female menopausal symptoms, replenishing qi and blood, and improving complexion, the raw materials of which include:

[0146] 15 parts of ginseng, 15 parts of angelica, 15 parts of mulberry fruits, 10 parts of raspberry, 12 parts of wolfberry, 20 parts of cassia seeds, 20 parts of polygonatum, 10 parts of polygonatum, 10 parts of sophora japonica flowers, 15 parts of dried longan meat, 6 parts of platycodon, 10 parts of tangerine peel, 15 parts of dandelion, 6 parts of rose, 6 parts of chrysanthemum procumbentum, 7 parts of loquat leaves, 10 parts of burdock roots, 6 parts of emblica fruits, 6 parts of bamboo leaves, 8 parts of dried ginger, and 7 parts of donkey-hide gelatin.

[0147] The specific preparation method is as follows:

[0148] 1. Weigh the herbs according to the above weight ratio, clean them, decoct them, remove the residue, and take the concentrated juice;

[0149] 2. Add 200 parts of honey and melt it into a paste.

[0150] Example 5

[0151] A paste prescription for improving female menopausal symptoms, replenishing qi and blood, and improving complexion, the raw materials of which include:

[0152] 135g ginseng, 180g angelica, 225g mulberry fruit, 180g raspberry, 180g wolfberry, 225g cassia seed, 225g polygonatum, 180g polygonatum, 135g sophora japonica flower, 225g longan meat, 135g platycodon, 225g tangerine peel, 225g dandelion, 90g rose, 450g chrysanthemum notoginseng, 135g loquat leaf, 225g burdock root, 135g emblica fruit, 135g bamboo leaf, 135g dried ginger, 135g donkey-hide gelatin.

[0153] The specific preparation method is as follows:

[0154] 1. Weigh the herbs according to the above weight ratio, clean them, add 8 times the amount of water, boil for 1 hour, remove the residue and take the concentrated juice;

[0155] 2. Add 200g of honey and melt it into a paste.

[0156] Example 6

[0157] A paste prescription for improving female menopausal symptoms, replenishing qi and blood, and improving complexion, the raw materials of which include:

[0158] 550g of ginseng, 500g of angelica, 550g of mulberry fruit, 500g of raspberry, 500g of wolfberry, 550g of cassia seed, 550g of polygonatum, 500g of polygonatum, 400g of sophora japonica flower, 550g of longan meat, 400g of platycodon, 550g of tangerine peel, 550g of dandelion, 250g of rose, 550g of chrysanthemum notoginseng, 250g of loquat leaf, 500g of burdock root, 250g of emblica fruit, 250g of bamboo leaf, 250g of dried ginger, and 250g of donkey-hide gelatin.

[0159] The specific preparation method is as follows:

[0160] 1. Weigh the herbs according to the above weight ratio, clean them, add 8 times the amount of water, boil for 1 hour, remove the residue and take the concentrated juice;

[0161] 2. Add 500g of honey and melt it into a paste.

[0162] Comparative Example 1

[0163] This comparative example is based on Example 1, but uses less of the three herbs of ginseng, cassia seed and polygonatum. Its preparation method is the same as that of Example 1.

[0164] Comparative Example 2

[0165] This comparative example is based on Example 1, and uses less of the three medicines of Angelica sinensis, Rubus idaeus, and Glehnia littoralis. Its preparation method is the same as that of Example 1.

[0166] Comparative Example 3

[0167] This comparative example is based on Example 1, and uses less of the three medicines, polygonatum, emblica fruit, and dried ginger. Its preparation method is the same as that of Example 1.

[0168] Comparative Example 4

[0169] This comparative example is based on Example 4, but uses less of the three medicines, wolfberry fruit, donkey-hide gelatin, and light bamboo leaf. Its preparation method is the same as that of Example 4.

[0170] Comparative Example 5

[0171] This comparative example is based on Example 4, and uses less of the four medicines of mulberry fruit, sophora japonica flower, orange peel, and rose flower. Its preparation method is the same as that of Example 4.

[0172] Comparative Example 6

[0173] This comparative example is based on Example 4, and uses less of the five medicinal herbs of dandelion, loquat leaf, burdock root, angelica, and platycodon. Its preparation method is the same as that of Example 4.

[0174] The effect test of the present invention is as follows:

[0175] 264 subjects meeting the diagnostic criteria for menopausal syndrome were randomly divided into 12 groups, each with 22 subjects. Six of the groups took the compositions prepared in Examples 1-6, and the other six groups took the compositions prepared in Comparative Examples 1-6. Each subject took 15 grams of the paste or granules orally once daily for 28 consecutive days.

[0176] Inclusion criteria: ① Comprehensive clinical diagnosis of menopausal syndrome; ② Exhibiting varying degrees of hot flashes, sweating, irritability and other symptoms; ③ Agreeing to cooperate with this trial.

[0177] Exclusion criteria: ① allergy to the treatment drugs or formula ingredients; ② taking estrogen drugs in the past month; ③ combined with gynecological malignancies; ④ withdrawal from the trial midway.

[0178] Observation indicators: ① Treatment effect. The clinical treatment effects of the 12 groups of patients were observed and divided into three categories: markedly effective (symptoms basically disappeared, and hormone levels returned to the normal range), effective (symptoms significantly improved compared to before treatment, and hormone levels improved), and ineffective (symptoms did not change significantly or even worsened compared to before treatment, and hormone levels were abnormal). The total effective rate = (markedly effective + effective) cases / total number of cases × 100.00%. ② Symptom score evaluation. Referring to the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes", the 12 groups of patients were evaluated for their symptoms before and after treatment, including: hot flashes and sweating, insomnia and dreaminess, dizziness, fatigue, and weakness. The score was 0-5 points, with 0 being no symptoms and 5 being very severe symptoms. The higher the score, the more intense and obvious the patient's symptoms.

[0179] Statistical methods: SPSS 25.0 was used as the statistical software for data analysis. 2 Inspection; measurement data The difference was statistically significant at P < 0.05.

[0180] 1. Treatment effect:

[0181]

[0182] Table 1 Comparison of treatment effects among 12 groups of patients

[0183] As can be seen from the data in Table 1, the total effective rate of the compositions prepared in Examples 1-6 in treating menopausal syndrome is significantly higher than that of the compositions prepared in Comparative Examples 1-6 (P<0.05). As can be seen from the results in Examples 1-6, the efficacy of the paste group is more significant than that of the granule group.

[0184] Comparative Example 1 used less ginseng, cassia seed, and polygonatum, so although it had a certain effect compared with before treatment, the total effective rate was lower than that of Example 1. It can be seen that the use of ginseng, cassia seed, and polygonatum together with the other 18 herbs can produce a synergistic effect, thereby improving menopausal symptoms.

[0185] Comparative Example 2 used less of the three herbs of Angelica sinensis, Rubus idaeus, and Glehnia littoralis, so although it had a certain effect compared with before treatment, the total effective rate was significantly lower than that of Example 2. It can be seen that the use of Angelica sinensis, Rubus idaeus, and Glehnia littoralis together with the other 18 herbs can produce a synergistic effect, thereby improving menopausal symptoms.

[0186] Comparative Example 3 used less of the three herbs of Polygonatum sibiricum, Emblica fructus and Dried Ginger, so although it had a certain effect compared with before treatment, the total effective rate was lower than that of Example 3. It can be seen that Polygonatum sibiricum, Emblica fructus and Dried Ginger can produce a synergistic effect with the other 18 herbs, thereby improving menopausal symptoms.

[0187] Comparative Example 4 used less of the three herbs, wolfberry, donkey-hide gelatin, and bamboo leaf, so although it had a certain effect compared with before treatment, the total effective rate was significantly lower than that of Example 4. It can be seen that the use of wolfberry, donkey-hide gelatin, and bamboo leaf together with the other 18 herbs can produce a synergistic effect, thereby improving menopausal symptoms.

[0188] Comparative Example 5 did not use the four herbs of mulberry fruit, sophora japonica flower, tangerine peel, and rose flower, so although it had a certain effect compared with before treatment, the total effective rate was significantly lower than that of Example 5. It can be seen that the four herbs of mulberry fruit, sophora japonica flower, tangerine peel, and rose flower, when used together with the other 17 herbs, can produce a synergistic effect, thereby improving menopausal symptoms.

[0189] Comparative Example 6 did not use the five herbs of dandelion, loquat leaf, burdock root, angelica, and platycodon, so although there was a certain effect compared with before treatment, the total effective rate was significantly lower than that of Example 6. It can be seen that the five herbs of dandelion, loquat leaf, burdock root, angelica, and platycodon, used together with the other 16 herbs, can improve menopausal symptoms due to their synergistic effect.

[0190] 2. Syndrome score:

[0191]

[0192] Table 2 Comparison of syndrome scores among 12 groups of patients (points, )

[0193] In Table 2, "Example" refers to the Example group, and "Comparative" refers to the Comparative Example group. As shown in Table 2, there was no statistically significant difference in the symptom scores of the 12 groups of patients before treatment (P>0.05). After treatment, the symptom scores of hot flashes, sweating, insomnia, dizziness, and fatigue in the Example group were lower than those in the Comparative Example group (P<0.05).

[0194] Moreover, since Comparative Example 1 used less of the three herbs, ginseng, cassia seed, and polygonatum, although it had some effect on the symptoms of hot flashes, sweating, insomnia, dizziness, and fatigue compared with before treatment, it was not as good as that of Example 1. It can be seen that the use of ginseng, cassia seed, and polygonatum together with the other 18 herbs can produce a synergistic effect, thereby improving menopausal symptoms.

[0195] Comparative Example 2 used less of the three herbs of Chinese angelica, raspberry, and flat chrysanthemum and Panax notoginseng. Although it had a certain effect on the symptoms of hot flashes, sweating, insomnia, dreaminess, dizziness, and fatigue compared with before treatment, it was not as good as the effect of Example 2. It can be seen that the three herbs of Chinese angelica, raspberry, and flat chrysanthemum and Panax notoginseng, when used together with the other 18 herbs, can produce a synergistic effect, thereby improving menopausal symptoms.

[0196] Comparative Example 3 used less of the three herbs, Polygonatum sibiricum, Emblica fructus, and Dried Ginger. Although it had a certain effect on the symptoms of hot flashes, sweating, insomnia, dreaminess, dizziness, and fatigue compared with before treatment, it was not as good as the effect of Example 3. It can be seen that Polygonatum sibiricum, Emblica fructus, and Dried Ginger can produce a synergistic effect with the other 18 herbs, thereby improving menopausal symptoms.

[0197] Comparative Example 4 used less of the three herbs, wolfberry, donkey-hide gelatin, and bamboo leaf. Although it had some effect on the symptoms of hot flashes, sweating, insomnia, dizziness, and fatigue compared with before treatment, it was not as good as the effect of Example 4. It can be seen that the three herbs, wolfberry, donkey-hide gelatin, and bamboo leaf, when used together with the other 18 herbs, can produce a synergistic effect, thereby improving menopausal symptoms.

[0198] Comparative Example 5, due to the lack of the four herbs of mulberry fruit, sophora japonica flower, tangerine peel, and rose flower, although it has a certain effect on the symptoms of hot flashes, sweating, insomnia, dizziness, and fatigue compared with before treatment, it is not as good as the effect of Example 5. It can be seen that the four herbs of mulberry fruit, sophora japonica flower, tangerine peel, and rose flower, when used together with the other 17 herbs, can produce a synergistic effect, thereby improving menopausal symptoms.

[0199] Comparative Example 6 did not use the five herbs of dandelion, loquat leaf, burdock root, angelica, and platycodon. Although it had some effect on the symptoms of hot flashes, sweating, insomnia, dizziness, and fatigue compared with before treatment, it was not as good as the effect of Example 6. It can be seen that the five herbs of dandelion, loquat leaf, burdock root, angelica, and platycodon, used together with the other 16 herbs, can improve menopausal symptoms due to their synergistic effect.

[0200] The Yellow Emperor's Classic of Internal Medicine states: "When a girl is seven years old, her kidney qi is strong, her teeth grow and her hair grows longer. At the age of 27, her celestial essence arrives, her Ren channel is open, her Taichong channel is strong, and her menstruation comes on time, so she can have children. At the age of 37, her kidney qi is balanced, so her real teeth grow and reach their maximum length. At the age of 47, her tendons and bones are strong, her hair reaches its maximum length, and her body is strong. At the age of 57, her Yangming channel weakens, her face begins to become scorched, and her hair begins to fall out. At the age of 67, the three Yang channels weaken on the upper part, her face becomes scorched, and her hair begins to turn white. At the age of 77, her Ren channel becomes weak, her Taichong channel weakens, her celestial essence is exhausted, and her Didao channel is blocked, so her body deteriorates and she cannot have children." After a girl is 47 (28), her middle earth gradually becomes weak. At the age of 57 (35), her kidney gradually weakens, and spots begin to appear on her face. The spleen and stomach are the foundation of the acquired constitution and the source of Qi and blood. The kidneys are the foundation of the innate constitution. The physiological activities of the five internal organs, as well as the operation and sublimation of Qi, blood, and spirit, depend on the fullness of kidney essence. The fullness of innate kidney essence relies on the nourishment of acquired Qi and blood generated by the spleen and stomach. When Qi and blood are full, essence remains. When essence remains, it becomes spirit, which is sublimated and fills the face. When spirit is full, facial spots disappear, and when spots disappear, a healthy complexion emerges.

[0201] Master of Traditional Chinese Medicine Liu Minru advocates the TCM health concept of "body and spirit working together to respond to the heaven and earth is the expression of healthy life", and expresses the healthy image of women as "women are based on yin, yin is responsible for storage and protection, its form is on the outside, and its appearance is based on the feminine and soft nature".

[0202] Ying is the essence of food and drink. It harmonizes the five zang organs and circulates throughout the six bowels before entering the meridians. Once in the meridians, it is transported to the heart and transformed into blood. Qi is the leader of blood, and blood is the end of qi. Essence and blood share the same origin. Nourishing blood requires regulating qi, which emphasizes the proper functioning of the five zang organs, particularly the kidneys and liver.

[0203] The selected medicinal herbs of the present invention include angelica sinensis, dried longan pulp, donkey hide gelatin, polygonatum, chrysanthemum and Panax notoginseng to nourish blood, generate blood, activate blood circulation and nourish the head and face skin; ginseng enters the spleen and regulates the middle, nourishes the heart and calms the mind, benefits the source of acquired qi and blood biochemical transformation, and helps the heart to generate blood; qi is the commander of blood, and ginseng is combined with platycodon to elevate and stimulate the smooth flow of blood throughout the body; polygonatum sibiricum, raspberry, mulberry fruit and wolfberry fruit to nourish the kidney, replenish yin and nourish essence and blood; cassia seed, tangerine peel, wolfberry fruit, raspberry, mulberry fruit and rose flower enter the liver to regulate blood, nourish liver yin and regulate liver qi. The medication of the present invention not only attaches importance to the generation and nourishment of essence and blood, but also takes into account the regulation of qi and blood, avoiding greasy and congested nourishment.

[0204] Women over 35 years old, especially women over 40 years old are prone to various hot, dry, or the performance of hyperactivity of yang because of hormone level change, such as dry throat, heat in the throat, irritability, unstable blood pressure etc. Therefore the present invention selects Flos Sophorae, Folium Bambusae, Folium Eriobotryae, Fructus Phyllanthuse, Fructus Phyllanthuse, Fructus Amomi, Radix Arctii, Herba Taraxaci, Semen Cassiae for use, prevents wind-heat from turning into dryness, heat-clearing and relieving sore throat. Taking has a refreshing feeling, and the malaise symptoms such as heat in the throat can be alleviated, alleviate or disappear, and yin-blood is gradually filled, and vital energy is gradually sufficient, and physical strength recovers, and spirit is also more abundant, can concentrate on doing things, and mood is also easier to stable. In addition, also less auxiliary dried ginger warms the middle part in the side, in case the product of cold and cool hurts the stomach.

[0205] The formula utilizes ingredients that are both edible and medicinal, harmonizing the five internal organs to nourish essence and blood, invigorating the six bowels and promoting renewal, maintaining women's health while also promoting a healthy and beautiful complexion. Long-term use nourishes essence and blood, promoting the smooth flow of Qi, leading to a refreshed mind, harmonious Qi and blood flow, and a revitalized spirit. It is suitable for perimenopausal women experiencing menstrual disorders and neuroendocrine disorders, such as mood swings, anxiety, hot flashes, night sweats, insomnia, and indigestion. It is also suitable for women experiencing Qi and blood deficiency, Yin blood deficiency, essence and blood deficiency, and poor complexion due to prolonged late nights, stress, and overwork.

[0206] Obviously, those skilled in the art may make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, if such modifications of the present invention fall within the scope of the claims and their equivalents, the present invention is intended to include such modifications and variations.

Claims

1. A composition for improving female menopausal symptoms, characterized in that: The active ingredients are the following materials in parts by weight: 2-35 parts of ginseng, 3-30 parts of angelica, 3-35 parts of mulberry, 2-30 parts of raspberry, 2-30 parts of wolfberry, 3-35 parts of cassia seed, 3-35 parts of polygonatum, 2-30 parts of polygonatum, 2-25 parts of sophora japonica flower, 3-35 parts of longan meat, 2-25 parts of platycodon, 2-35 parts of tangerine peel, 3-35 parts of dandelion, 1-15 parts of rose, 1-40 parts of chrysanthemum procumbentum, 2-15 parts of loquat leaf, 2-30 parts of burdock root, 2-15 parts of emblica fruit, 2-15 parts of bamboo leaf, 2-15 parts of dried ginger, and 2-15 parts of donkey-hide gelatin.

2. The composition for improving female menopausal symptoms according to claim 1, characterized in that: The composition further comprises a pharmaceutically acceptable carrier.

3. A method for preparing a granule for improving female menopausal symptoms, characterized in that: The following steps are involved: The first step is to weigh the medicinal materials according to the following weight ratio and clean them; 2-35 parts of ginseng, 3-30 parts of angelica, 3-35 parts of mulberry, 2-30 parts of raspberry, 2-30 parts of wolfberry, 3-35 parts of cassia seed, 3-35 parts of polygonatum, 2-30 parts of polygonatum, 2-25 parts of sophora japonica flower, 3-35 parts of longan pulp, 2-25 parts of platycodon, 2-35 parts of tangerine peel, 3-35 parts of dandelion, 1-15 parts of rose, 1-40 parts of chrysanthemum procumbentum, 2-15 parts of loquat leaf, 2-30 parts of burdock root, 2-15 parts of emblica fruit, 2-15 parts of bamboo leaf, 2-15 parts of dried ginger, and 2-15 parts of donkey-hide gelatin. The second step is to dry the medicinal materials and grind them into powder; The third step is to fully mix the medicinal powder and then sterilize it at high temperature; The fourth step is to add excipients, form granules and form particles; The fifth step is to sterilize again at high temperature.

4. A method for preparing a paste prescription for improving female menopausal symptoms, characterized in that: The following steps are involved: The first step is to weigh the medicinal materials according to the following weight ratio, clean them, decoct them, remove the residue, and take the concentrated juice; 2-35 parts of ginseng, 3-30 parts of angelica, 3-35 parts of mulberry, 2-30 parts of raspberry, 2-30 parts of wolfberry, 3-35 parts of cassia seed, 3-35 parts of polygonatum, 2-30 parts of polygonatum, 2-25 parts of sophora japonica flower, 3-35 parts of longan pulp, 2-25 parts of platycodon, 2-35 parts of tangerine peel, 3-35 parts of dandelion, 1-15 parts of rose, 1-40 parts of chrysanthemum procumbentum, 2-15 parts of loquat leaf, 2-30 parts of burdock root, 2-15 parts of emblica fruit, 2-15 parts of bamboo leaf, 2-15 parts of dried ginger, and 2-15 parts of donkey-hide gelatin. The second step is to add 200 to 500 parts of honey, melt it and make a paste.

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