A device for sampling intestinal flora

Abstract

The present invention relates to the field of feces sampling technology, and specifically to an intestinal flora sampling device. The intestinal flora sampling device involved in the present invention includes a sampling chamber, and the sampling chamber includes a sampling shell, a first partition plate is arranged inside the sampling shell, at least two retention tubes are arranged at the bottom of the first partition plate, and a fixed base is arranged on the outside of the retention tube, and the fixed base is arranged in the sampling shell. Among them, the retention tube is installed in cooperation with the protrusion at the bottom of the first partition plate, and the retention tube can be directly pulled out. Through this detachable assembly, the efficiency of sample detection is improved, and the efficiency of cleaning is improved, and some feces residue is avoided inside the device. After a single patient uses it for detection, it only needs to replace the retention tube and clean other devices before it can be used by the next patient, which further reduces the cost of use.

Description

Technical Field

[0001] The invention relates to the technical field of feces sampling, and in particular to an intestinal flora sampling device. Background Art

[0002] Colorectal cancer (CRC) accounts for approximately 10% of cancers and cancer-related deaths diagnosed worldwide each year. It is the second most common cancer diagnosed in women and the third most common cancer in men. Early screening for colorectal cancer is very valuable because there is ample evidence that early detection and removal of precancerous lesions or focal adenomas, polyps, etc. can prevent cancer and reduce mortality. Currently, the gold standard for diagnosing colorectal cancer is still to obtain specimens for pathological examination by colonoscopy, but due to its invasiveness, high cost, and possible complications, its use rate for early screening of colorectal cancer is relatively low. The collection of fecal samples has the advantages of being non-invasive and convenient, and is one of the widely used indicators for early screening of colorectal cancer. Feces can provide changes in the metabolism of intestinal flora, which is conducive to multi-target DNA detection and is a potential biomarker.

[0003] Clinically, some patients may have difficulty collecting stool due to mobility problems caused by advanced age or spinal diseases. In addition, most colorectal cancer patients will experience symptoms such as constipation, diarrhea, and bloody stools, which will cause a mixture of solid and liquid in the stool, making it difficult to separate and extract, and causing great difficulties in stool collection and subsequent testing and research. Therefore, clinically, there is a need for an intestinal flora sampling device that can collect without contact and automatically separate solids and liquids.

[0004] The prior art provides some solutions, such as patent US11839363B2, which provides a comprehensive device for fecal sampling and detection. Occult blood detection, with quantitative detection function to collect, dissolve, filter, and immunodetect fecal samples in strips, which is easy to carry and operate, and the device will not leak any liquid during operation. Storage, transportation and detection. The device can meet - quickly collect constant samples, without pollution and leakage, and can quickly determine the results of occult blood without the help of other items. The device can detect occult blood in feces at any time and any place, which can help you. Overcome the problem of low inspection rate. Convenient for fecal submission and inspection, further promote the detection of fecal occult blood, and can increase the early diagnosis and screening rate of colorectal cancer in the population. However, the patent is not convenient in subsequent processing and cleaning of the device, and it cannot be reused. Here, the inventor believes that there is still a lot of room for improvement. Summary of the invention

[0005] In order to achieve the technical effect. The present invention provides an intestinal flora sampling device, comprising: a sampling chamber, the sampling chamber comprising a sampling shell, a first partition plate is arranged inside the sampling shell, at least two retention tubes are arranged at the bottom of the first partition plate, a fixed base is arranged outside the retention tube, and the fixed base is arranged inside the sampling shell.

[0006] In the present invention, a cylindrical protrusion is arranged at the bottom of the first partition plate, and a first hole is arranged at the center of the protrusion, and the first hole is aligned with the center of the retention tube.

[0007] Furthermore, the sampling chamber is mainly used to place the patient's feces. Since some patients may have symptoms such as constipation, diarrhea, and bloody stools, which may cause the feces to be mixed with solids and liquids, a screen is provided above a retention tube, which can separate the solids in the feces and allow the liquid to flow into the retention tube through the screen. The retention tube on the other side is not provided with a screen for retaining the solids in the feces. In this way, the purpose of solid-liquid separation of feces is achieved, and the difficulty of subsequent detection and research is reduced. In addition, the part of the sampling housing arranged at the lower end of the first partition plate can be rotated to separate the upper and lower parts of the sampling housing, thereby showing the internal retention tube to the outside. Since the retention tube is installed in cooperation with the protrusion at the bottom of the first partition plate, the retention tube can be directly pulled off. This detachable assembly improves the efficiency of sample detection and the efficiency of cleaning, and avoids some feces residue inside the device. After a single patient has finished the test, it only needs to replace the retention tube and clean other devices before it can be used by the next patient, further reducing the cost of use.

[0008] In the present invention, the fixing base includes a first groove, a fastening base is installed in the first groove, and the fastening base is adapted to the retention tube.

[0009] In the present invention, the fastening base includes an annular buckle, the bottom of the annular buckle is connected to a first spring, the other end of the first spring is connected to the first groove, and the radius of the annular buckle is smaller than the radius of the retention tube head.

[0010] Furthermore, the fastening base is used to fix the retention tube. When the retention tube and the protrusion are installed, the annular buckle on the sampling housing can be aligned with the retention tube, and the lower part of the sampling housing can be aligned with the upper part of the sampling housing, and the lower part of the sampling housing can be rotated. It is worth mentioning here that the lower part of the sampling housing is divided into a rotatable part and a non-rotatable part, wherein the fastening base is arranged in the non-rotatable part, and the rotatable part is provided with a thread inside to be matched with the upper part of the sampling housing. In the process of gradually rotating and installing, the annular buckle contacts the head of the retention tube. At the same time, the first spring at the lower part of the retention tube is compressed to fix the position of the lower part of the retention tube, so as to avoid the operator failing to install the retention tube accurately and vertically when installing the retention tube, which may cause feces to leak to the outside of the device during the subsequent sampling and separation process, making it impossible for the retention tube to effectively collect a certain amount of sample. By setting a fastening base, the end of the retention tube is tapered, and the annular buckle just fixes the retention tube. At the same time, the reverse thrust generated by the compression of the first spring further fixes the current position of the retention tube, and can also calibrate the current position of the retention tube to avoid deviation of the retention tube.

[0011] In the present invention, a second hole is provided on the first partition plate, a sharp corner is provided above the second hole, and the sharp corner is fixedly connected to the upper surface of the first partition plate. A separation device is sleeved above the sampling chamber, and the lower end of the separation device can abut against the first partition plate.

[0012] Furthermore, if the patient's feces is hard and difficult to collect, it is necessary to remove the separation device on the sampling chamber. Since the separation head on the separation device has a hole in the center and the end of the separation head is pointed, it is convenient for the patient to take a small part of the sample from the harder feces on the separation head. At this time, the separation device is inserted into the through hole in the center of the sampling chamber, and the sleeve joint is rotated to make the separation device and the sampling chamber completely sealed.

[0013] In the present invention, the separation device includes a sleeve joint, a thread is provided inside the sleeve joint to cooperate with the sampling housing, the sleeve joint is centrally rotatably connected to a first column, a slide sleeve is sleeved on the first column, and a separation head is provided inside the first column.

[0014] Furthermore, after the sleeve joint is assembled with the sampling shell, that is, the two are completely merged, since the first column is rotatably connected to the sleeve joint, the other end of the first column extends to the outside of the sleeve joint, and the separation head inside the first column can be pushed out by rotating the first column. The separation head is provided with an "X"-shaped partition substrate at the head of the separation head. The partition substrate can squeeze and separate the feces in the sampling chamber to prevent the feces from clogging the inside of the sampling chamber and realize solid-liquid separation.

[0015] In the present invention, the separation head includes an extrusion push rod, a symmetrical positioning rod is arranged at the tail of the extrusion push rod, a first slide groove is opened on the first column, an arc-shaped second slide groove is opened inside the slide groove sleeve, and the positioning rod can move in the first slide groove and the second slide groove at the same time.

[0016] Furthermore, the partition substrate is fixedly connected to the extrusion push rod. When the extrusion push rod is rotated, the extrusion push rod rotates and moves downward along the first slide groove and the second slide groove, thereby pressing down the patient's harder feces. Since a circular base is arranged in the middle of the first groove inside the sampling shell, the feces can be separated into multiple sections under the action of the extrusion push rod. Since a screen is arranged at the end of the retention tube on one side and the retention tube on the other side is not arranged at the screen, the feces on the upper side of the retention tube with the screen can be further squeezed by the partition substrate connected to the end of the extrusion push rod. At the same time, since the extrusion push rod is pushed out while rotating, the patient's feces can be better squeezed to increase the content of liquid obtained in a single sampling, thereby improving the sampling efficiency.

[0017] Compared with the prior art, the significant technical progress of the present invention is that: since the retention tube is installed in cooperation with the protrusion at the bottom of the first partition plate, the retention tube can be directly pulled out. This detachable assembly improves the efficiency of sample detection and the cleaning efficiency, avoiding the presence of some feces residue inside the device. After a single patient has finished the test, it only needs to replace the retention tube and clean other devices before it can be used by the next patient, further reducing the cost of use. The separation head is provided with an "X"-shaped partition substrate, which can squeeze and separate the feces in the sampling bin to avoid the feces clogging the inside of the sampling bin and achieve solid-liquid separation. The feces on the upper side of the retention tube with the screen can be further squeezed by the partition substrate connected to the end of the extrusion push rod. At the same time, since the extrusion push rod is pushed out while rotating, it can better squeeze the patient's feces to increase the content of liquid obtained by a single sampling and improve the efficiency of sampling. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of an intestinal flora sampling device involved in the present invention;

[0019] Figure 2 It is a schematic cross-sectional structure diagram of the intestinal flora sampling device involved in the present invention;

[0020] Figure 3 for Figure 2 The enlarged structural diagram at A in the middle;

[0021] Figure 4 It is a schematic structural diagram of the separation device involved in the present invention.

[0022] Explanation of the reference numerals: 1-sampling chamber; 11-sampling housing; 12-first partition plate; 121-protrusion; 122-first hole body; 123-second hole body; 13-retention tube; 14-fixed base; 141-first groove; 15-fastening base; 151-annular buckle; 152-first spring; 2-separation device; 21-sleeve joint; 22-first column; 221-first slide groove; 23-slide groove sleeve; 231-second slide groove; 24-separation head; 241-extrusion push rod; 242-positioning rod. DETAILED DESCRIPTION

[0023] Embodiment 1:

[0024] Reference Figure 1 , Figure 2 , Figure 3 As shown, the present invention provides an intestinal flora sampling device, including: a sampling chamber 1, the sampling chamber 1 includes a sampling shell 11, a first partition plate 12 is arranged inside the sampling shell 11, at least two retention tubes 13 are arranged at the bottom of the first partition plate 12, a fixed base 14 is arranged on the outer side of the retention tube 13, and the fixed base 14 is arranged in the sampling shell 11.

[0025] In the present invention, a cylindrical protrusion 121 is disposed at the bottom of the first partition plate 12 , and a first hole 122 is disposed at the center of the protrusion 121 , and the first hole 122 is aligned with the center of the retention tube 13 .

[0026] Furthermore, the sampling chamber 1 is mainly used to place the patient's feces. Since some patients may have symptoms such as constipation, diarrhea, and bloody stools, which may cause the feces to be mixed with solid and liquid, a screen is set above a retention tube 13, which can separate the solids in the feces and allow the liquid to pass through the screen and flow into the retention tube 13. The retention tube 13 on the other side is not set with a screen to retain the solids in the feces. In this way, the purpose of solid-liquid separation of feces is achieved, reducing the difficulty of subsequent detection and research. In addition, the portion of the sampling housing 11 arranged at the lower end of the first partition plate 12 can be rotated to separate the upper and lower portions of the sampling housing 11, thereby exposing the internal retention tube 13 to the outside. Since the retention tube 13 is installed in cooperation with the protrusion 121 at the bottom of the first partition plate 12, the retention tube 13 can be directly pulled out. This detachable assembly improves the efficiency of sample detection and the efficiency of cleaning, thereby avoiding some feces residue inside the device. After a single patient has finished the test, it only needs to replace the retention tube 13 and clean other devices before it can be used by the next patient, thereby further reducing the cost of use.

[0027] In the present invention, the fixing base 14 includes a first groove 141 , in which a fastening base 15 is installed, and the fastening base 15 is adapted to the retention tube 13 .

[0028] In the present invention, the fastening base 15 includes an annular buckle 151, the bottom of the annular buckle 151 is connected to a first spring 152, the other end of the first spring 152 is connected to the first groove 141, and the radius of the annular buckle 151 is smaller than the radius of the head of the retention tube 13.

[0029] Furthermore, the fastening base 15 is used to fix the retention tube 13. When the retention tube 13 and the protrusion 121 are installed, the annular buckle 151 on the sampling housing 11 can be aligned with the retention tube 13, and at the same time, the lower part of the sampling housing 11 is aligned with the upper part of the sampling housing 11, and the lower part of the sampling housing 11 is rotated. It is worth mentioning here that the lower part of the sampling housing 11 is divided into a rotatable part and a non-rotatable part, wherein the fastening base 15 is arranged in the non-rotatable part, and the rotatable part is provided with a thread inside, which can be matched with the upper part of the sampling housing 11. In the process of gradually rotating and installing, the annular buckle 151 contacts the head of the retention tube 13. At the same time, the first spring 152 at the lower part of the retention tube 13 is compressed to fix the position of the lower part of the retention tube 13, so as to avoid that the operator fails to install the retention tube 13 accurately and vertically when installing the retention tube 13, thereby causing feces to leak to the outside of the device during the subsequent sampling and separation process, so that the retention tube 13 cannot effectively collect a certain amount of sample. By setting the fastening base 15, the end of the retention tube 13 is tapered, and the annular buckle 151 just fixes the retention tube 13. At the same time, the reverse thrust generated by the compression of the first spring 152 further fixes the current position of the retention tube 13, and can also calibrate the current position of the retention tube 13 to avoid the deviation of the retention tube 13.

[0030] In the present invention, a second hole 123 is provided on the first partition plate 12, and a sharp corner is provided above the second hole 123, and the sharp corner is fixedly connected to the upper surface of the first partition plate 12. A separation device 2 is sleeved above the sampling chamber 1, and the lower end of the separation device 2 can abut against the first partition plate 12.

[0031] Furthermore, if the patient's feces is hard and difficult to collect, it is necessary to remove the separation device 2 on the sampling chamber 1. Since the separation head 24 on the separation device 2 has a central opening and the end of the separation head 24 is pointed, it is convenient for the patient to take a small portion of the sample from the harder feces on the separation head 24. At this time, the separation device 2 is inserted into the through hole in the center of the sampling chamber 1, and the sleeve joint 21 is rotated to make the separation device 2 and the sampling chamber 1 completely sealed.

[0032] Embodiment 2:

[0033] Reference Figure 1 , Figure 2 , Figure 4As shown, in the present invention, the separation device 2 includes a sleeve joint 21, a thread is provided inside the sleeve joint 21 and can cooperate with the sampling housing 11, the sleeve joint 21 is centrally rotatably connected to a first column 22, a slide sleeve 23 is sleeved on the first column 22, and a separation head 24 is provided inside the first column 22.

[0034] Furthermore, after the sleeve joint 21 is assembled with the sampling housing 11, that is, the two are completely merged, since the first column 22 is rotatably connected to the sleeve joint 21, the other end of the first column 22 extends to the outside of the sleeve joint 21, and the separation head 24 inside the first column 22 can be pushed out by rotating the first column 22. The head of the separation head 24 is provided with an "X"-shaped partition substrate, which can squeeze and separate the feces in the sampling chamber 1 to prevent the feces from clogging the inside of the sampling chamber 1 and realize solid-liquid separation.

[0035] In the present invention, the separation head 24 includes an extrusion push rod 241, a symmetrical positioning rod 242 is provided at the tail of the extrusion push rod 241, a first slide groove 221 is provided on the first column 22, and an arc-shaped second slide groove 231 is provided inside the slide groove sleeve 23, and the positioning rod 242 can move in the first slide groove 221 and the second slide groove 231 at the same time.

[0036] Furthermore, the partition substrate is fixedly connected to the extrusion push rod 241. When the extrusion push rod 241 is rotated, the extrusion push rod 241 rotates and moves downward along the first slide groove 221 and the second slide groove 231, thereby pressing down the patient's harder feces. Since a circular base is arranged in the middle of the first groove 141 inside the sampling housing 11, the feces can be separated into multiple sections under the action of the extrusion push rod 241. Since a screen is arranged at the end of the retention tube 13 on one side and no screen is arranged at the retention tube 13 on the other side, the feces on the upper side of the retention tube 13 on the side with the screen can be further squeezed by the partition substrate connected to the end of the extrusion push rod 241. At the same time, since the extrusion push rod 241 is pushed out while rotating, the patient's feces can be better squeezed to increase the content of liquid obtained by a single sampling, thereby improving the sampling efficiency.

[0037] Embodiment 3:

[0038] As an optional solution, when the patient's symptom is diarrhea and it is inconvenient to collect solid samples, a connecting rope can be installed on the outside of the sampling chamber 1, and a net sleeve is also provided on the outside of the connecting rope, which can be installed on the toilet. When the patient takes a sample, the separation device 2 connected to the sampling chamber 1 is removed, and the net sleeve is installed on the toilet. At this time, the position of the sampling chamber 1 is just aligned with the middle of the toilet, which is convenient for the patient to complete the sampling. Similarly, after the sampling is completed, the separation device 2 needs to be covered and tightened to prevent leakage of the internal sample.

[0039] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the attached claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any figure mark in the claims should not be regarded as limiting the claims involved.

Claims

1. An intestinal flora sampling device, comprising: A sampling chamber (1), the sampling chamber (1) comprising a sampling housing (11), characterized in that a first partition plate (12) is arranged inside the sampling housing (11), at least two retention tubes (13) are arranged at the bottom of the first partition plate (12), a fixed base (14) is arranged outside the retention tube (13), and the fixed base (14) is arranged inside the sampling housing (11); A cylindrical protrusion (121) is provided at the bottom of the first partition plate (12); The first partition plate (12) is provided with a second hole (123), a partition plate is arranged above the second hole (123), and the partition plate is fixedly connected to the upper surface of the first partition plate (12); a separation device (2) is sleeved above the sampling chamber (1), and the lower end of the separation device (2) can abut against the first partition plate (12); A screen is disposed above at least one retention tube (13), and no screen is disposed above at least one retention tube (13); A first hole (122) is provided at the center of the protrusion (121), and the first hole (122) is aligned with the center of the retention tube (13); The fixed base (14) comprises a first groove (141), a fastening base (15) is installed in the first groove (141), and the fastening base (15) is adapted to fit the retention tube (13); A connecting rope is sleeved on the outside of the sampling chamber (1), and a net sleeve is also arranged on the outside of the connecting rope.

2. The intestinal flora sampling device according to claim 1, characterized in that: The fastening base (15) comprises an annular buckle (151), the bottom of the annular buckle (151) is connected to a first spring (152), the other end of the first spring (152) is connected to the first groove (141), and the radius of the annular buckle (151) is smaller than the radius of the head of the retention tube (13).

3. The intestinal flora sampling device according to claim 1, characterized in that: The separation device (2) comprises a sleeve joint (21), wherein a thread is arranged inside the sleeve joint (21) and can be matched with the sampling housing (11), and the sleeve joint (21) is centrally rotatably connected to a first column (22), a slide sleeve (23) is sleeved on the first column (22), and a separation head (24) is arranged inside the first column (22).

4. The intestinal flora sampling device according to claim 3, characterized in that: The separation head (24) comprises an extrusion push rod (241), a positioning rod (242) is arranged at the tail of the extrusion push rod (241), a first slide groove (221) is provided on the first column (22), an arc-shaped second slide groove (231) is provided inside the slide groove sleeve (23), and the positioning rod (242) can move in the first slide groove (221) and the second slide groove (231) at the same time.

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