Propofol blood concentration detection sampling and collection system and method

Abstract

The invention discloses a propofol blood drug concentration detection sampling collection system and method, comprising: a positioning base structure; a sample storage structure to be tested, and the sample storage structure to be tested is set as a continuously translatable sample to be tested pool; a detection sample storage structure, and the detection sample storage structure is set as a continuously translatable sample detection pool; a displacement drive structure, and the displacement drive structure has a corresponding horizontal and vertical linear kinetic energy output end; an injector structure, which is fixed to the linear kinetic energy output end of the displacement drive structure; a suction and blowing air pump structure, and the suction and blowing air pump structure has an air extraction end and an air blowing end connected to the injector structure through a pipeline. The invention solves the technical problems that the operation process of the prior art for real-time monitoring of propofol concentration in plasma depends on manual blood collection and transfer, the operation process is time-consuming and laborious, the overall automation degree is low, the continuity is poor, there is a blank period, and it is difficult to maintain efficient and continuous real-time monitoring of propofol concentration in plasma.

Description

Technical Field

[0001] The present invention relates to the technical field of propofol blood drug analysis, and in particular to a propofol blood drug concentration detection sampling and collection system and method. Background Art

[0002] At present, propofol is widely used as a medical intravenous anesthetic for inducing and maintaining anesthesia due to its excellent performance in rapid induction elimination, short duration of effect, mild recovery after anesthesia, few side effects, and no teratogenic effects. At the same time, the correlation influencing factors between different patients and the pharmacokinetic parameters of propofol lead to significant inter-individual differences in propofol anesthesia, that is, the use of too high or too low doses of propofol may cause individual propofol infusion syndrome and intraoperative anesthesia failure. In summary, real-time monitoring of plasma propofol concentration during surgery is particularly important to ensure the smooth progress of the operation.

[0003] In the prior art, intraoperative real-time monitoring of propofol concentration in plasma generally still relies on manual blood sampling and transfer to detection instruments and equipment. The transfer operation process is time-consuming and labor-intensive, the overall degree of automation is low, the continuity is poor, and there is a blank period, making it difficult to maintain efficient and continuous real-time monitoring of propofol concentration in plasma. Summary of the invention

[0004] To this end, the present invention provides a propofol blood concentration detection sampling and collection system and method to solve the technical problems in the prior art of real-time monitoring of propofol concentration in plasma relying on manual blood sampling and transfer, such as time-consuming and labor-intensive operation process, low overall automation level, poor continuity, blank period, and difficulty in maintaining efficient and continuous real-time monitoring of propofol concentration in plasma.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] A propofol blood concentration detection sampling and collection system, comprising:

[0007] Positioning base structure;

[0008] The sample storage structure to be tested is fixedly assembled on the positioning base structure, and the sample storage structure to be tested is configured as a continuously transferable sample pool to be tested;

[0009] A detection sample storage structure is fixedly assembled on the positioning base structure, and the detection sample storage structure is configured as a continuously transferable sample detection pool;

[0010] A displacement driving structure is fixedly assembled on the positioning base structure, and the displacement driving structure has a linear kinetic energy output end corresponding to the horizontal and vertical directions;

[0011] An injector structure, fixedly assembled and arranged at the linear kinetic energy output end of the displacement drive structure;

[0012] The suction and blowing air pump structure is fixedly assembled on the positioning base structure, and the suction and blowing air pump structure respectively has an air suction end and an air blowing end connected to the injector structure through pipelines.

[0013] On the basis of the above technical solution, the present invention is further described as follows:

[0014] As a further solution of the present invention, the sample storage structure to be tested includes a first driving motor, a first transmission assembly, a first disc turntable and a blood drug liquid tank to be tested;

[0015] The base of the first drive motor is fixedly assembled on the top surface of the positioning base structure, and the rotational kinetic energy output end of the first drive motor is connected to the input end of the first transmission assembly by a transmission assembly;

[0016] The first disc turntable is horizontally connected and assembled on the top surface of the positioning base structure, and the first disc turntable is connected and assembled with the output end of the first transmission assembly;

[0017] The blood drug liquid tanks to be tested are provided in a plurality of groups, and the plurality of groups of blood drug liquid tanks to be tested are respectively arranged in a circular manner and opened on the top surface of the first disc turntable;

[0018] The detection sample storage structure includes a second driving motor, a second disc turntable and a detection blood medicine tank;

[0019] The base of the second drive motor is fixedly assembled on the top surface of the positioning base structure, the second disc turntable is horizontally assembled on the top surface of the positioning base structure, and the rotational kinetic energy output end of the second drive motor is connected to the second disc turntable through a second transmission assembly.

[0020] The blood test liquid tanks are provided in a plurality of groups, and the blood test liquid tanks in the plurality of groups are arranged in a circular manner and opened on the top surface of the second disc turntable.

[0021] As a further solution of the present invention, the displacement drive structure includes a screw-driven vertical frame and a screw-driven horizontal frame;

[0022] The screw-driven stand is provided with two groups, and the two groups of screw-driven stand are both vertically extended, and the bottom base parts of the two groups of vertical screw-driven stand are fixedly assembled and connected with the top surface of the positioning base structure;

[0023] The screw-driven horizontal frame is extended horizontally, and the two ends of the base of the screw-driven horizontal frame are respectively connected to the linear kinetic energy output ends of the two groups of vertical screw-driven vertical frames in a one-to-one correspondence and transmission fixed assembly;

[0024] The sample injector structure is fixedly assembled on the linear kinetic energy output end of the lead screw driving cross frame.

[0025] As a further solution of the present invention, the sample injector structure includes a sample injection accommodating tube and a sample injection connector;

[0026] The sample intake accommodating tube is fixedly assembled and arranged on the linear kinetic energy output end portion of the screw drive cross frame;

[0027] The sample injection connector is detachably fixedly mounted on the sample injection accommodating tube;

[0028] The suction and blowing air pump structure comprises an air pump body and an air delivery pipe;

[0029] The air pump body is fixedly mounted on the positioning base structure, and the air extraction end and the air blowing end of the air pump body are respectively connected to the sample injection accommodating tube through the air delivery tube in a closed manner.

[0030] As a further solution of the present invention, it also includes:

[0031] An electric control structure, fixedly assembled on the positioning base structure;

[0032] The electric control structure includes a power module and a control module connected by a circuit;

[0033] The control output end of the control module is connected to the input end of the relay through a circuit, and the output end of the relay is respectively connected to the first drive motor in the sample storage structure to be tested, the second drive motor in the detection sample storage structure, the screw drive vertical frame and the screw drive horizontal frame in the displacement drive structure, and the air pump body in the suction and blowing air pump structure through a circuit.

[0034] As a further solution of the present invention, the injection joint comprises a joint limiting portion, a joint sleeve portion and an extended liquid pipe portion which are sequentially fixedly connected;

[0035] The propofol blood drug concentration detection sampling and collection system also includes:

[0036] The joint assembly structure includes an assembly main board, a guide rail plate, a support stop plate and a spring member;

[0037] The mounting mainboard is fixedly assembled and arranged at the middle top position of the first disc turntable, and the mounting mainboard is provided with a plurality of groups of limiting channels which correspond vertically to the plurality of groups of the blood medicine tanks to be tested in a circular manner;

[0038] The guide rail plates are provided in a plurality of groups, and the guide rail plates in the plurality of groups are vertically extended and fixedly connected to the bottom end surface of the mounting main board, and the guide rail plates in the plurality of groups are respectively and one by one located at the inner side of the circumference of the plurality of groups of the limiting channels;

[0039] The supporting and stopping plates and the spring members are provided in a plurality of groups, and the plurality of supporting and stopping plates are respectively and one by one vertically slidably assembled on the plurality of guide rail plates, and the plurality of spring members are respectively and one by one fixedly connected between the plurality of supporting and stopping plates and the mounting main board;

[0040] The bottom end of the guide rail plate is fixedly connected with a guide rail limiting portion for limiting the sliding position of the supporting stop plate;

[0041] The mounting main board is provided with sleeve portion displacement channels with side openings on the outer peripheral sides corresponding to a plurality of groups of the limiting channels, and the supporting stop plate is provided with liquid pipe portion displacement channels with side openings.

[0042] As a further solution of the present invention, when the injection connector is in a state to be docked, the inner edge of the limiting channel and the outer edge of the connector limiting portion of the injection connector are nested and matched.

[0043] As a further solution of the present invention, it also includes:

[0044] The connector disassembly structure includes a disassembly main board, a liquid supply channel and a limiting elastic wheel;

[0045] The disassembly mainboard is fixedly assembled and arranged at the middle top position of the second disc turntable, and the disassembly mainboard is circularly provided with a plurality of groups of liquid feeding channels corresponding vertically to the plurality of groups of the blood drug detection tanks;

[0046] The position-limiting elastic wheels are provided in a plurality of groups, and the plurality of groups of the position-limiting elastic wheels are respectively and one-to-one connected to the inner side walls of the plurality of groups of the liquid supply channels, and each group of the position-limiting elastic wheels is provided with a plurality of position-limiting elastic wheels, and the plurality of the position-limiting elastic wheels are all rotatably arranged in a one-way bearing type, that is, the plurality of the position-limiting elastic wheels corresponding to one side of the center of the liquid supply channel are all only rotatably arranged from top to bottom;

[0047] The plurality of limit elastic wheels are all elastic outer-wrapped wheel bodies.

[0048] A collection method according to the propofol blood concentration detection sampling collection system comprises the following steps:

[0049] The obtained blood-drug mixture to be tested is stored in a plurality of groups of blood-drug liquid tanks to be tested through the sample storage structure to be tested, and one group of tanks of the sample storage structure to be tested is controlled to rotate to a specific position;

[0050] The control shift driving structure drives the sampler structure to rotate to one of the groups of slots in the specific position corresponding to the sample storage structure to be tested, and continues to control the shift driving structure to drive the sampler structure's sample injection tube to perform the liquid collection process. The sample injection tube is automatically shifted downward by the driving action of the shift driving structure to connect the sample injection joint. At this time, the joint sleeve portion in the sample injection joint is further pressed down by the contact pressure to press the supporting stop plate in the joint assembly structure. The supporting stop plate slides downward along the guide plate in the joint assembly structure under the contact pressure, so that the extended liquid pipe portion in the sample injection joint gradually penetrates into the interior of the blood medicine tank to be tested, until the supporting stop plate slides to the guide limit portion of the guide plate, and the supporting stop plate limited by the guide limit portion simultaneously forms a limiting stop effect on the joint sleeve portion, so that the sample injection tube that continues to shift downward is automatically and stably connected with the joint sleeve portion, and after the connection, the suction and blowing air pump structure is used to suck the gas in the sample injection tube to form a negative pressure, and finally the blood medicine mixture is absorbed based on the extended liquid pipe portion.

[0051] As a further solution of the present invention, the following steps are also included:

[0052] Controlling one group of slots of the detection sample storage structure to rotate to a specific position;

[0053] The shift drive structure is further controlled to drive the sample injector structure to rotate to one of the slots in the specific position corresponding to the detection sample storage structure, and the shift drive structure is continued to drive the sample injector structure to perform the liquid feeding process. The sample injector tube is automatically shifted downward by the driving action of the shift drive structure, and the suction and blowing pump structure is used to blow air to the sample injector tube, so that the sample injector tube is based on the joint sleeve part and the extended liquid tube part of the sample injector joint, and the blood-drug mixture delivery process is completed through the liquid feeding channel in the joint removal structure;

[0054] When the connector sleeve part of the injection connector is inserted into the liquid feeding channel, the connector sleeve part is smoothly put into place to complete the blood-drug mixture delivery process through the driving action of the displacement driving structure and the rollability of several limiting elastic wheels in the connector removal structure;

[0055] Then, when the sample injection accommodating tube is pulled back, the connector sleeve portion is limited by the fixed elastic contact pressure of a plurality of limiting elastic wheels, so that the connector sleeve portion and the sample injection accommodating tube are automatically disassembled and separated.

[0056] The present invention has the following beneficial effects:

[0057] The system and method effectively form a continuously translatable sample test pool and a continuously translatable sample detection pool for obtaining a blood-drug mixture based on a bottom support body structure through a sample storage structure for testing and a sample storage structure for detection. At the same time, the driving energy output by the displacement driving structure can be used to drive the injector structure to effectively shift between the sample test pool and the sample detection pool. The suction and blowing pump structure can be used in conjunction with the injector structure to achieve air extraction and liquid extraction when corresponding to the sample test pool, and air blowing and liquid feeding when corresponding to the sample detection pool, thereby effectively completing the automated continuous transfer process for the detection of a blood-drug mixture, and can efficiently and continuously monitor the propofol concentration in plasma in real time, thereby improving the overall functional adaptability and practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0058] In order to more clearly illustrate the implementation mode of the present invention or the technical solution in the prior art, the drawings required for the implementation mode or the description of the prior art will be briefly introduced below. The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0059] Figure 1 This is a schematic diagram of the overall axonometric structure of the propofol blood concentration detection sampling and collection system provided in Example 1 of the present invention.

[0060] Figure 2 This is a schematic diagram of the assembly structure of the sample storage structure to be tested in the propofol blood concentration detection sampling and collection system provided in Example 1 of the present invention.

[0061] Figure 3 This is a schematic diagram of the lateral assembly structure of the connector assembly structure in the propofol blood concentration detection sampling and collection system provided in Example 2 of the present invention.

[0062] Figure 4 This is a schematic diagram of the limiting assembly structure between the support stop plate of the connector assembly structure and the injection connector in the propofol blood concentration detection injection and collection system provided in Example 2 of the present invention.

[0063] Figure 5 This is a structural schematic diagram of the assembly mainboard of the connector assembly structure in the propofol blood drug concentration detection sampling and collection system provided in Example 2 of the present invention.

[0064] Figure 6 This is a schematic diagram of the limiting assembly structure between the assembly main board of the connector assembly structure and the injection connector in the propofol blood concentration detection injection and collection system provided in Example 2 of the present invention.

[0065] Figure 7 This is a schematic diagram of the lateral assembly structure of the connector disassembly structure in the propofol blood concentration detection sampling and collection system provided in Example 2 of the present invention.

[0066] Figure 8 This is a schematic diagram of the top view of the connector removal structure in the propofol blood concentration detection sampling and collection system provided in Example 2 of the present invention.

[0067] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0068] Positioning base structure 1;

[0069] The sample storage structure 2 to be tested includes a first driving motor 21, a first transmission assembly 22, a first disc turntable 23, and a blood drug liquid tank 24 to be tested;

[0070] Detection sample storage structure 3: second drive motor 31, second disc turntable 32, detection blood medicine tank 33;

[0071] Shift driving structure 4: screw-driven vertical frame 41, screw-driven horizontal frame 42;

[0072] Injector structure 5: injection accommodating tube 51, injection connector 52, connector limiting portion 521, connector sleeve portion 522, and extended liquid tube portion 523;

[0073] Suction and blowing air pump structure 6: air pump body 61, air delivery pipe 62;

[0074] The joint assembly structure 7 includes an assembly main board 71, a limiting channel 711, a sleeve portion displacement channel 712, a guide rail plate 72, a guide rail limiting portion 721, a support stop plate 73, a liquid pipe portion displacement channel 731, and a spring member 74;

[0075] Connector disassembly structure 8: disassemble the main board 81, liquid supply channel 82, and limit elastic wheel 83;

[0076] Electronic control structure 9. DETAILED DESCRIPTION

[0077] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0078] The terms such as "upper", "lower", "left", "right", and "middle" used in this specification are only for the convenience of description and are not intended to limit the scope of the invention. Changes or adjustments to their relative relationships should be regarded as within the scope of the invention without substantially changing the technical content.

[0079] Example 1

[0080] like Figure 1 to Figure 2 As shown, an embodiment of the present invention provides a propofol blood drug concentration detection sampling and collection system, including a positioning base structure 1, a sample storage structure 2 to be tested, a sample storage structure 3 to be tested, a displacement drive structure 4, an injector structure 5, a suction and blowing air pump structure 6 and an electric control structure 9, which are used to effectively form a continuously transferable sample test pool and a continuously transferable sample detection pool for obtaining a blood-drug mixture based on the bottom support body structure 1 through the sample storage structure 2 to be tested and the sample storage structure 3 to be tested, and at the same time, the drive energy output by the displacement drive structure 4 can be used to drive the injector structure 5 to effectively shift between the sample test pool and the sample detection pool, and the suction and blowing air pump structure 6 can be used in conjunction with the injector structure 5 to achieve air extraction and liquid collection when corresponding to the sample test pool, and air blowing and liquid feeding when corresponding to the sample detection pool, thereby effectively completing the automated continuous transfer process for blood-drug mixture detection, and can maintain efficient and continuous real-time monitoring of propofol concentration in plasma, thereby improving the overall functional adaptability and practicality. The specific settings are as follows:

[0081] Please refer to Figure 1 and Figure 2 The positioning base structure 1 is used as the assembly basis of the overall structure; the sample storage structure 2 to be tested includes a first drive motor 21, a first transmission assembly 22, a first disc turntable 23 and a blood drug liquid tank 24 to be tested; wherein the base of the first drive motor 21 is fixedly assembled on the top surface of the positioning base structure 1, and the rotational kinetic energy output end of the first drive motor 21 and the input end of the first transmission assembly 22 are connected by a transmission assembly; the first disc turntable 23 is horizontally transferred and assembled on the top surface of the positioning base structure 1, and the first disc turntable 23 and the output end of the first transmission assembly 22 are connected by a transmission assembly The transmission assembly is connected and arranged between them; the blood drug liquid tanks 24 to be tested are provided with a plurality of groups, and the plurality of groups of the blood drug liquid tanks 24 to be tested are respectively arranged in a circular manner and opened on the top surface of the first disc turntable 23; it is used to effectively realize the storage of the obtained blood drug mixture to be tested in the slots through the above arrangement, and at the same time, when the blood drug mixture is transferred to the detection sample storage structure 3, the rotational kinetic energy output by the first driving motor 21 can be used to effectively drive the first disc turntable 23 to rotate via the first transmission component 22, so that the plurality of groups of blood drug liquid tanks 24 to be tested are respectively transferred in sequence to correspond to the bottom of the sample injector structure 5, thereby being able to cooperate with the sample injector structure 5 to effectively realize automatic continuous liquid extraction.

[0082] The detection sample storage structure 3 includes a second drive motor 31, a second disc turntable 32 and a detection blood medicine liquid tank 33; wherein, the base of the second drive motor 31 is fixedly assembled on the top surface of the positioning base structure 1, the second disc turntable 32 is horizontally assembled on the top surface of the positioning base structure 1, and the rotational kinetic energy output end of the second drive motor 31 is connected to the second disc turntable 32 via a second transmission assembly; the detection blood medicine liquid tank 33 is provided with a plurality of groups, and the plurality of groups of the detection blood medicine liquid tank 33 are provided with a plurality of groups of the detection blood medicine liquid tank 33. The medicine liquid tanks 33 are arranged in a circular manner and opened on the top surface of the second disc turntable 32; the above-mentioned arrangement is used to effectively realize the detection of the transferred blood-drug mixture in the slots. When the transferred blood-drug mixture reaches the detection sample storage structure 3, the rotational kinetic energy output by the second drive motor 31 can be used to effectively drive the second disc turntable 32 to rotate through the second transmission component, so that several groups of detection blood drug liquid tanks 33 are sequentially transferred to the corresponding positions directly below the sample injector structure 5, thereby cooperating with the sample injector structure 5 to effectively realize automated continuous liquid feeding and its subsequent detection process.

[0083] Please continue to refer to Figure 1 The displacement driving structure 4 includes a screw-driven vertical frame 41 and a screw-driven horizontal frame 42; wherein, the screw-driven vertical frame 41 is provided with two groups, and the two groups of the screw-driven vertical frames 41 are both vertically extended, and the bottom base parts of the two groups of vertical screw-driven vertical frames 41 are both fixedly assembled and connected with the top surface of the positioning base structure 1; the screw-driven horizontal frame 42 is horizontally extended, and the two ends of the base of the screw-driven horizontal frame 42 are respectively corresponding to the linear kinetic energy output ends of the two groups of vertical screw-driven vertical frames 41 for transmission and fixed assembly.

[0084] The sample injector structure 5 includes a sample injection accommodating tube 51 and a sample injection connector 52 detachably mounted on the sample injection accommodating tube 51. The sample injection accommodating tube 51 is fixedly mounted on the linear kinetic energy output end of the screw drive cross frame 42, so as to effectively drive the sample injector structure 5 to complete the predetermined displacement process and liquid feeding process with the help of the vertical and horizontal linear kinetic energy output by the displacement drive structure 4.

[0085] The suction and blowing air pump structure 6 includes an air pump body 61 and an air delivery pipe 62; wherein, the air pump body 61 is fixedly assembled on the top surface of the positioning base structure 1, and the suction end and the blowing end of the air pump body 61 are respectively connected to the sample injection accommodating tube 51 through the air delivery pipe 62 in a closed manner, so as to form negative pressure liquid extraction by controlling the suction when the sampler structure 5 corresponds to the sample test pool, and to push the liquid by controlling the blowing when the sampler structure 5 corresponds to the sample detection pool.

[0086] The electric control structure 9 is fixedly assembled on the top surface of the positioning base structure 1. Specifically, the electric control structure 9 includes a power module and a control module connected by a circuit. The control module can be selected from but not limited to a single-chip microcomputer control board of model AT80C51 and a microcontroller of model STM32; the control output end of the control module is connected to the input end of a relay through a circuit, and the output end of the relay is respectively connected to the first drive motor 21 in the sample storage structure 2 to be tested, the second drive motor 31 in the detection sample storage structure 3, the screw drive vertical frame 41 and the screw drive horizontal frame 42 in the shift drive structure 4, and the air pump body 61 in the suction and blowing air pump structure 6 through a circuit, so as to effectively realize the automatic control continuous transfer process of the entire architecture, thereby maintaining efficient and continuous real-time monitoring of the propofol concentration in plasma, significantly improving the overall functional adaptability and practicality.

[0087] Example 2

[0088] In Example 2, the same symbols are given to the same structures as in Example 1, and the same descriptions are omitted. Example 2 is improved on the basis of Example 1, please refer to Figures 3 to 8 The propofol blood concentration detection sampling and collection system also includes a connector assembly structure 7 and a connector removal structure 8, which are used to effectively realize the automated assembly and removal of the disposable sampling connector 52 through the cooperation of the connector assembly structure 7 and the connector removal structure 8, further effectively improving the overall automation level and convenience.

[0089] Specifically, please refer to Figures 3 to 6The injection connector 52 includes a connector limiting portion 521, a connector sleeve portion 522 and an extension liquid pipe portion 523 which are fixedly connected in sequence; the connector assembly structure 7 includes an assembly main board 71, a guide plate 72, a support stop plate 73 and a spring member 74; wherein the assembly main board 71 is fixedly assembled and arranged at the middle top position of the first disc turntable 23, and the assembly main board 71 is circularly provided with a plurality of groups of limiting channels 711 which correspond vertically to a plurality of groups of the blood drug liquid tanks 24 to be tested; the guide plate 72 is provided with a plurality of groups of guide rails, and a plurality of groups of guide rails are provided with a plurality of groups of guide rails. The plates 72 are all vertically extended and fixedly connected to the bottom end surface of the mounting main board 71, and several groups of the guide rail plates 72 are respectively and one by one located at the circumferential inner side of several groups of the limiting channels 711; the support stop plates 73 and the spring members 74 are each provided with several groups, and several groups of the support stop plates 73 are respectively and one by one vertically slidably assembled on several groups of the guide rail plates 72, and several groups of the spring members 74 are respectively and one by one fixedly connected between several groups of the support stop plates 73 and the mounting main board 71; the bottom end of the guide rail plate 72 is also integrally fixedly provided with The guide rail limiting portion 721 is used to limit the sliding position of the support stop plate 73; it is used to achieve the guiding effect of the guide rail plate 72 and the elastic effect of the spring member 74, so that the support stop plate 73 can slide downward within a specific range under the contact pressure, and can automatically return to its original position elastically after the contact pressure is released. Specifically, it can be used when the sample injection accommodating tube 51 is performing a liquid extraction process. The sample injection accommodating tube 51 is automatically driven downward by the displacement driving structure 4 to connect with the sample injection connector 52. At this time, the connector sleeve portion 522 in the sample injection connector 52 is further pressed downward by the contact pressure to support the stopper. The support and stop plate 73 slides downward within the limit range of the guide rail limit portion 721 under the contact pressure, so that the extended liquid tube portion 523 in the sampling connector 52 gradually penetrates into the interior of the blood medicine liquid tank 24 to be tested, until the support and stop plate 73 slides to the guide rail limit portion 721, and the limited support and stop plate 73 simultaneously forms a limit stop effect on the connector sleeve portion 522, thereby making the sampling accommodating tube 51 that continues to shift downward and the connector sleeve portion 522 automatically and stably docked, and after docking, the blood medicine mixture is absorbed based on the extended liquid tube portion 523.

[0090] Please continue to refer to Figures 4 to 6 The mounting main board 71 is provided with a sleeve portion displacement channel 712 with a side opening on the outer side corresponding to the plurality of groups of the limiting channels 711, and the supporting stop plate 73 is provided with a liquid tube portion displacement channel 731 with a side opening, so as to smoothly shift the sample receiving tube 51 through the sleeve portion displacement channel 712 and the liquid tube portion displacement channel 731 after completing the blood-drug mixed liquid aspiration process.

[0091] As a preferred solution of this embodiment, the inner edge of the limiting channel 711 and the outer edge of the connector limiting portion 521 of the injection connector 52 are nested and matched with each other, so as to effectively improve the positioning of the injection connector 52 and the stability of its subsequent docking function when the injection connector 52 is in a docking state.

[0092] Please refer to Figure 7 and Figure 8 The connector disassembly structure 8 includes a disassembly main board 81, a liquid feeding channel 82 and a limiting elastic wheel 83; wherein the disassembly main board 81 is fixedly assembled and arranged at the middle top position of the second disc turntable 32, and the disassembly main board 81 is circularly opened with a plurality of groups of liquid feeding channels 82 corresponding vertically to a plurality of groups of the blood drug detection tanks 33, so that the connector sleeve portion 522 and the extension liquid tube portion 523 of the injection connector 52 can complete the blood drug mixture delivery through the liquid feeding channel 82; the limiting elastic wheel 83 is provided with a plurality of groups, and the plurality of groups of the limiting elastic wheels 83 are respectively and one by one connected to the inner side walls of the plurality of groups of the liquid feeding channels 82, and each group of the limiting elastic wheels 83 is provided with a plurality of, and the plurality of the limiting elastic wheels 83 are The one-way bearing type rotation setting, that is, several of the limiting elastic wheels 83 corresponding to one side of the center of the liquid feeding channel 82 are all only rotated from top to bottom, and several of the limiting elastic wheels 83 are elastic outer wheel bodies; so that when the joint sleeve part 522 of the sampling joint 52 is inserted into the liquid feeding channel 82, through external drive and the rollability of several limiting elastic wheels 83, the joint sleeve part 522 can be smoothly put into place to complete the blood-drug mixture delivery process, and then when the sampling accommodating tube 51 is pulled back, the joint sleeve part 522 is limited by the fixed elastic contact pressure of several limiting elastic wheels 83, thereby enabling the joint sleeve part 522 and the sampling accommodating tube 51 to be automatically disassembled and separated, further improving the degree of automation and convenience.

[0093] The embodiment of the present invention also provides an application collection method of the propofol blood concentration detection sampling collection system, which specifically includes the following steps:

[0094] The obtained blood-drug mixture to be tested is stored in the test sample storage structure 2 based on a plurality of groups of blood-drug liquid tanks 24 to be tested, and one group of tanks of the test sample storage structure 2 is controlled to rotate to a specific position;

[0095] The shift driving structure 4 is controlled to drive the sample injector structure 5 to rotate to one of the slots in the specific position corresponding to the sample storage structure 2 to be tested, and the shift driving structure 4 is continued to drive the sample injection tube 51 of the sample injector structure 5 to perform the liquid collection process. The sample injection tube 51 is automatically shifted downward to dock with the sample injection connector 52 by the driving action of the shift driving structure 4. At this time, the connector sleeve portion 522 in the sample injection connector 52 is further pressed downward by the contact pressure action to press the support stop plate 73 in the connector assembly structure 7. The support stop plate 73 is pressed downward along the guide plate 72 in the connector assembly structure 7, so that The extended liquid tube portion 523 in the sampling connector 52 gradually penetrates into the interior of the blood medicine tank 24 to be tested, until the supporting stop plate 73 slides to the guide rail limiting portion 721 of the guide rail plate 72, and the supporting stop plate 73 limited by the guide rail limiting portion 721 simultaneously forms a limiting stop effect on the connector sleeve portion 522, so that the sampling accommodating tube 51 that continues to move downward is automatically and stably connected with the connector sleeve portion 522, and after the connection, the gas in the sampling accommodating tube 51 is sucked by the suction and blowing air pump structure 6 to form a negative pressure, and finally the blood medicine mixture is sucked based on the extended liquid tube portion 523;

[0096] Controlling one group of slots of the detection sample storage structure 3 to rotate to a specific position;

[0097] The shift driving structure 4 is further controlled to drive the sample injector structure 5 to rotate to one of the slots in the specific position corresponding to the detection sample storage structure 3, and the shift driving structure 4 is continued to drive the sample injector structure 5 to perform the liquid feeding process. The sample injector 51 is automatically shifted downward by the driving action of the shift driving structure 4, and the sample injector 51 is blown by the suction and blowing pump structure 6, so that the sample injector 51 is based on the joint sleeve part 522 and the extended liquid tube part 523 of the sample injector 52, and the blood-drug mixture delivery process is completed through the liquid feeding channel 82 in the joint removal structure 8;

[0098] When the connector sleeve portion 522 of the injection connector 52 is inserted into the liquid feeding channel 82, the connector sleeve portion 522 is smoothly put into place to complete the blood-drug mixture delivery process through the driving action of the displacement driving structure 4 and the rollability of the plurality of limiting elastic wheels 83 in the connector disassembly structure 8. Then, when the injection accommodating tube 51 is pulled back, the connector sleeve portion 522 is limited by the fixed elastic contact pressure of the plurality of limiting elastic wheels 83, so that the connector sleeve portion 522 and the injection accommodating tube 51 are automatically disassembled and separated.

[0099] The propofol blood drug concentration detection sampling and collection system can set the moving path, moving speed and injection volume of the sampler structure 5 through software, and can also exchange data streams with the blood drug concentration detection device to achieve automatic detection of the blood drug concentration detection device after sample injection and control the number of sample detections.

[0100] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A propofol blood concentration detection sampling and collection system, characterized in that: include: Positioning base structure; The sample storage structure to be tested is fixedly assembled on the positioning base structure, and the sample storage structure to be tested is configured as a continuously transferable sample pool to be tested; A detection sample storage structure is fixedly assembled on the positioning base structure, and the detection sample storage structure is configured as a continuously transferable sample detection pool; The detection sample storage structure includes a second disc turntable and a detection blood medicine tank; The blood test liquid tanks are provided in a plurality of groups, and the blood test liquid tanks in the plurality of groups are arranged in a circular manner and opened on the top surface of the second disc turntable; A displacement driving structure is fixedly assembled on the positioning base structure, and the displacement driving structure has a linear kinetic energy output end corresponding to the horizontal and vertical directions; The sample injector structure is fixedly assembled and arranged on the linear kinetic energy output end of the displacement drive structure; the sample injector structure includes a sample injection connector; A suction and blowing air pump structure is fixedly assembled on the positioning base structure, and the suction and blowing air pump structure has an air suction end and an air blowing end connected to the injector structure through pipelines; The sample storage structure to be tested includes a first driving motor, a first transmission assembly, a first disc turntable and a blood drug liquid tank to be tested; The base of the first drive motor is fixedly assembled on the top surface of the positioning base structure, and the rotational kinetic energy output end of the first drive motor is connected to the input end of the first transmission assembly by a transmission assembly; The first disc turntable is horizontally connected and assembled on the top surface of the positioning base structure, and the first disc turntable is connected and assembled with the output end of the first transmission assembly; The blood drug liquid tanks to be tested are provided in a plurality of groups, and the plurality of groups of blood drug liquid tanks to be tested are respectively arranged in a circular manner and opened on the top surface of the first disc turntable; The injection joint comprises a joint limiting part, a joint sleeve part and an extended liquid pipe part which are fixedly connected in sequence; The propofol blood drug concentration detection sampling and collection system also includes: The joint assembly structure includes an assembly main board, a guide rail plate, a support stop plate and a spring member; The mounting mainboard is fixedly assembled and arranged at the middle top position of the first disc turntable, and the mounting mainboard is provided with a plurality of groups of limiting channels which correspond vertically to the plurality of groups of the blood medicine tanks to be tested in a circular manner; The guide rail plates are provided in a plurality of groups, and the guide rail plates in the plurality of groups are vertically extended and fixedly connected to the bottom end surface of the mounting main board, and the guide rail plates in the plurality of groups are respectively and one by one located at the inner side of the circumference of the plurality of groups of the limiting channels; The supporting and stopping plates and the spring members are provided in a plurality of groups, and the plurality of supporting and stopping plates are respectively and one by one vertically slidably assembled on the plurality of guide rail plates, and the plurality of spring members are respectively and one by one fixedly connected between the plurality of supporting and stopping plates and the mounting main board; The bottom end of the guide rail plate is fixedly connected with a guide rail limiting portion for limiting the sliding position of the supporting stop plate; The mounting main board is provided with sleeve portion displacement channels with side openings on the outer side of the plurality of groups of the limiting channels, and the supporting stop plate is provided with liquid pipe portion displacement channels with side openings; When the injection connector is in a state to be docked, the inner edge of the limiting channel and the outer edge of the connector limiting portion of the injection connector are nested and matched; The propofol blood concentration detection sampling and collection system further comprises: The connector disassembly structure includes a disassembly main board, a liquid supply channel and a limiting elastic wheel; The disassembly mainboard is fixedly assembled and arranged at the middle top position of the second disc turntable, and the disassembly mainboard is circularly provided with a plurality of groups of liquid feeding channels corresponding vertically to the plurality of groups of the blood drug detection tanks; The position-limiting elastic wheels are provided in a plurality of groups, and the plurality of groups of the position-limiting elastic wheels are respectively and one-to-one connected to the inner side walls of the plurality of groups of the liquid supply channels, and each group of the position-limiting elastic wheels is provided with a plurality of position-limiting elastic wheels, and the plurality of the position-limiting elastic wheels are all rotatably arranged in a one-way bearing type, that is, the plurality of the position-limiting elastic wheels corresponding to one side of the center of the liquid supply channel are all only rotatably arranged from top to bottom; The plurality of limit elastic wheels are all elastic outer-wrapped wheel bodies.

2. The propofol blood concentration detection sampling and collection system according to claim 1, characterized in that: The detection sample storage structure includes a second driving motor; The base of the second drive motor is fixedly assembled on the top surface of the positioning base structure, the second disc turntable is horizontally assembled on the top surface of the positioning base structure, and the rotational kinetic energy output end of the second drive motor is connected to the second disc turntable via a second transmission assembly.

3. The propofol blood concentration detection sampling and collection system according to claim 2, characterized in that: The displacement driving structure includes a screw-driven vertical frame and a screw-driven horizontal frame; The screw-driven stand is provided with two groups, and the two groups of screw-driven stand are both vertically extended, and the bottom base parts of the two groups of vertical screw-driven stand are fixedly assembled and connected with the top surface of the positioning base structure; The screw-driven horizontal frame is extended horizontally, and the two ends of the base of the screw-driven horizontal frame are respectively connected to the linear kinetic energy output ends of the two groups of vertical screw-driven vertical frames in a one-to-one correspondence and transmission fixed assembly; The sample injector structure is fixedly assembled on the linear kinetic energy output end of the lead screw driving cross frame.

4. The propofol blood concentration detection sampling and collection system according to claim 3, characterized in that: The sample injector structure comprises a sample injection accommodating tube; The sample intake accommodating tube is fixedly assembled and arranged on the linear kinetic energy output end portion of the screw drive cross frame; The sample injection connector is detachably fixedly mounted on the sample injection accommodating tube; The suction and blowing air pump structure comprises an air pump body and an air delivery pipe; The air pump body is fixedly mounted on the positioning base structure, and the air extraction end and the air blowing end of the air pump body are respectively connected to the sample injection accommodating tube through the air delivery tube in a closed manner.

5. The propofol blood concentration detection sampling and collection system according to claim 4, characterized in that: Also includes: An electric control structure, fixedly assembled on the positioning base structure; The electric control structure includes a power module and a control module connected by a circuit; The control output end of the control module is connected to the input end of the relay through a circuit, and the output end of the relay is respectively connected to the first drive motor in the sample storage structure to be tested, the second drive motor in the detection sample storage structure, the screw drive vertical frame and the screw drive horizontal frame in the displacement drive structure, and the air pump body in the suction and blowing air pump structure through a circuit.

6. A collection method according to the propofol blood concentration detection sampling collection system as claimed in claim 5, characterized in that: The steps include: The obtained blood-drug mixture to be tested is stored in a plurality of groups of blood-drug liquid tanks to be tested through the sample storage structure to be tested, and one group of tanks of the sample storage structure to be tested is controlled to rotate to a specific position; The control shift driving structure drives the sampler structure to rotate to one of the groups of slots in the specific position corresponding to the sample storage structure to be tested, and continues to control the shift driving structure to drive the sampler structure's sample injection tube to perform the liquid collection process. The sample injection tube is automatically shifted downward by the driving action of the shift driving structure to connect the sample injection joint. At this time, the joint sleeve portion in the sample injection joint is further pressed down by the contact pressure to press the supporting stop plate in the joint assembly structure. The supporting stop plate slides downward along the guide plate in the joint assembly structure under the contact pressure, so that the extended liquid pipe portion in the sample injection joint gradually penetrates into the interior of the blood medicine tank to be tested, until the supporting stop plate slides to the guide limit portion of the guide plate, and the supporting stop plate limited by the guide limit portion simultaneously forms a limiting stop effect on the joint sleeve portion, so that the sample injection tube that continues to shift downward is automatically and stably connected with the joint sleeve portion, and after the connection, the suction and blowing air pump structure is used to suck the gas in the sample injection tube to form a negative pressure, and finally the blood medicine mixture is absorbed based on the extended liquid pipe portion.

7. The collection method according to claim 6, characterized in that: The following steps are also included: Controlling one group of slots of the detection sample storage structure to rotate to a specific position; The shift drive structure is further controlled to drive the sample injector structure to rotate to one of the slots in the specific position corresponding to the detection sample storage structure, and the shift drive structure is continued to drive the sample injector structure to perform the liquid feeding process. The sample injector tube is automatically shifted downward by the driving action of the shift drive structure, and the suction and blowing pump structure is used to blow air to the sample injector tube, so that the sample injector tube is based on the joint sleeve part and the extended liquid tube part of the sample injector joint, and the blood-drug mixture delivery process is completed through the liquid feeding channel in the joint removal structure; When the connector sleeve part of the injection connector is inserted into the liquid feeding channel, the connector sleeve part is smoothly put into place to complete the blood-drug mixture delivery process through the driving action of the displacement driving structure and the rollability of several limiting elastic wheels in the connector removal structure; Then, when the sample injection accommodating tube is pulled back, the connector sleeve portion is limited by the fixed elastic contact pressure of a plurality of limiting elastic wheels, so that the connector sleeve portion and the sample injection accommodating tube are automatically disassembled and separated.

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