A method, system and electronic device for measuring impedance of human tissue

Abstract

The present disclosure provides a method, system and electronic device for measuring the impedance of human tissue, wherein the method comprises: determining multiple initial supply voltages of a detection current based on a preset current value, wherein the detection current is the current output by a target electrode in contact with human tissue, and the initial supply voltage is used to generate the detection current; obtaining multiple current data corresponding to each initial supply voltage and an output voltage value corresponding to each current data, wherein the output voltage value is a voltage value output to both ends of the human tissue; determining the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the multiple current data. By performing multiple detections on the detection current, obtaining multiple current data and output voltage values, and determining the impedance of the human tissue based on the multiple current data and output voltage values, the accuracy of determining the impedance of the human tissue is improved.

Description

Technical Field

[0001] The present disclosure relates to the field of neural regulation technology, and in particular to a method, system and electronic device for measuring impedance of human tissue. Background Art

[0002] Neuromodulation technology refers to the biomedical engineering technology that uses implantable or non-implantable technology, physical or chemical means, to excite, inhibit or mediate the transduction of neurons or neural network signals in adjacent or distant parts of the central nervous system, peripheral nervous system and autonomic nervous system, thereby improving the quality of life of patients and enhancing their neurological functions. When using neuromodulation products to treat or regulate patients, the neuromodulation products are required to stably output a specific frequency, specific pulse width and a specific current value acting on the patient's body.

[0003] The current output by the neuromodulation product needs to be a stable constant current when acting on the patient's body, while the impedance of the human tissue is a changing value. Therefore, in order to ensure the accuracy of the current acting on the patient's body, the impedance of the human tissue needs to be accurately measured. At present, the measurement of human tissue is mainly based on the principle of Ohm's law. The impedance value of human tissue is calculated by measuring the voltage difference between a pair of electrodes and the output current value at a single time. However, the impedance of human tissue will change with the body's water content, skin moisture, muscle tension, body temperature, blood flow, etc., which leads to the problem of low accuracy of the impedance of human tissue obtained by a single measurement. Summary of the invention

[0004] In view of this, the present disclosure provides a method, system and electronic device for measuring the impedance of human tissue, which can improve the accuracy of measuring the impedance of human tissue.

[0005] According to a first aspect of an embodiment of the present disclosure, a method for measuring impedance of human tissue is provided, the method comprising:

[0006] Based on the preset current value, determining a plurality of initial supply voltages of the detection current, wherein the detection current is a current output by a target electrode in contact with the human tissue and flowing through the human tissue;

[0007] Acquire a plurality of current data corresponding to each initial supply voltage and an output voltage value corresponding to each current data, wherein the initial supply voltage is used to generate the detection current, and the output voltage value is a voltage value output to both ends of the human tissue;

[0008] The target impedance of the human tissue is determined based on the actual current value and the corresponding output voltage value in the multiple current data corresponding to each initial supply voltage.

[0009] In one embodiment, determining the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the multiple current data corresponding to each initial supply voltage includes:

[0010] Determine the group of each current data according to the frequency or pulse width in the multiple current data corresponding to each initial supply voltage, wherein the frequency and pulse width of the current in each group of current data are the same;

[0011] The target impedance of the human tissue is determined according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

[0012] In one embodiment, determining the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value includes:

[0013] Determine multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data;

[0014] Screening the multiple initial impedances according to a preset error range;

[0015] The target impedance of the human tissue is determined based on an average value of the multiple initial impedances after screening.

[0016] In one embodiment, the method further comprises:

[0017] Determine, among the plurality of current data and output voltage values, target current data and target output voltage value corresponding to the target impedance;

[0018] Determine, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value;

[0019] If there are multiple candidate power supply voltages, the minimum power supply voltage among the candidate power supply voltages is determined as the target power supply voltage.

[0020] In one embodiment, the method further comprises:

[0021] Determining a connection state between the target electrode and the human tissue according to the target impedance;

[0022] Alternatively, the amount of fat accumulation in the human tissue is determined based on the target impedance and the target corresponding relationship, wherein the target corresponding relationship is the corresponding relationship between the impedance of the human tissue and the amount of fat accumulation.

[0023] According to a second aspect of an embodiment of the present disclosure, a system for measuring impedance of human tissue is provided, the system comprising:

[0024] A current source unit, configured to generate a detection current, wherein the detection current is a current output by a target electrode in contact with the human tissue and flowing through the human tissue;

[0025] A current detection unit, used for acquiring a plurality of current data of the detection current based on a preset current value;

[0026] A voltage detection unit, used to obtain an output voltage value corresponding to each current data; the output voltage value is a voltage value output to both ends of the human tissue;

[0027] The main control unit is used to determine the target impedance of the human tissue based on the real current values ​​and the corresponding output voltage values ​​in the multiple current data.

[0028] In one embodiment, when the main control unit determines the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the plurality of current data, it includes:

[0029] Determining a group of each current data according to the frequency or pulse width in the plurality of current data, wherein the frequency and pulse width of the current in each group of current data are the same;

[0030] The target impedance of the human tissue is determined according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

[0031] In one embodiment, when the main control unit determines the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value, it includes:

[0032] Determine multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data;

[0033] Screening the multiple initial impedances according to a preset error range;

[0034] The target impedance of the human tissue is determined based on an average value of the multiple initial impedances after screening.

[0035] In one embodiment, the main control unit is further used for:

[0036] Determine, among the plurality of current data and output voltage values, target current data and target output voltage value corresponding to the target impedance;

[0037] Determine, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value;

[0038] If there are multiple candidate power supply voltages, the minimum power supply voltage among the candidate power supply voltages is determined as the target power supply voltage.

[0039] According to a third aspect of an embodiment of the present disclosure, an electronic device is provided, wherein the electronic device comprises the human tissue impedance measurement system described in any one of the second aspects above.

[0040] According to a fourth aspect of an embodiment of the present disclosure, a device for measuring impedance of human tissue is provided, the device comprising:

[0041] an acquisition module, configured to acquire a plurality of current data of a detection current and an output voltage value corresponding to each current data based on a preset current value, wherein the detection current is a current output by a target electrode in contact with the human tissue and flowing through the human tissue, and the output voltage value is a voltage value output to both ends of the human tissue;

[0042] A determination module is used to determine the target impedance of the human tissue based on the real current values ​​and the corresponding output voltage values ​​in the multiple current data.

[0043] The technical solution provided by the embodiments of the present disclosure may have the following beneficial effects:

[0044] By performing multiple detections on the detection current, multiple current data and output voltage values ​​are obtained, and the impedance of the human tissue is determined based on the multiple current data and output voltage values, the accuracy of determining the impedance of the human tissue is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 is a flow chart of a method for measuring human body impedance shown in an exemplary embodiment of the present disclosure;

[0046] Figure 2 is a flow chart of a method for determining target impedance shown in an exemplary embodiment of the present disclosure;

[0047] Figure 3 is a flow chart of another method for determining target impedance shown in an exemplary embodiment of the present disclosure;

[0048] Figure 4 is a flow chart of a method for determining a target power supply voltage shown in an exemplary embodiment of the present disclosure;

[0049] Figure 5 is a framework diagram of a human body impedance measurement system shown in an exemplary embodiment of the present disclosure;

[0050] Figure 6 It is a block diagram of a device for measuring human body impedance shown in an exemplary embodiment of the present disclosure. DETAILED DESCRIPTION

[0051] Exemplary embodiments will be described in detail herein, examples of which are shown in the accompanying drawings. When the following description refers to the drawings, the same numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present disclosure. Instead, they are merely examples of devices and methods consistent with some aspects of the present disclosure as detailed in the appended claims.

[0052] The terms used in this disclosure are for the purpose of describing specific embodiments only and are not intended to limit the disclosure. The singular forms of "a", "said" and "the" used in this disclosure and the appended claims are also intended to include plural forms unless the context clearly indicates otherwise. It should also be understood that the term "and / or" used herein refers to and includes any or all possible combinations of one or more associated listed items.

[0053] It should be understood that although the terms first, second, third, etc. may be used in the present disclosure to describe various information, such information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of the present disclosure, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Depending on the context, the word "if" as used herein may be interpreted as "at the time of" or "when" or "in response to determining".

[0054] Neuromodulation products are electronic products that use neuromodulation technology to regulate the human neural network through physical or chemical means. Neuromodulation products can output stable stimulation currents, and the patient's body can be regulated through the stimulation currents. After the output electrodes of the neuromodulation product are connected to human tissue, a current loop is formed between the human tissue and the neuromodulation product. In order to ensure that the stimulation current flowing through the human tissue is a bi-phase symmetrical square wave or a single-phase square wave stimulation current with a constant current value, it is necessary to adjust the power supply voltage of the neuromodulation product according to the impedance of the human tissue to ensure the accuracy of the stimulation current and the regulation effect of the neuromodulation product.

[0055] At present, the method for measuring human tissue impedance is generally to collect the voltage difference and current value between the electrodes at both ends of the neuromodulation product once, and calculate the impedance of the human tissue based on the voltage difference and current value based on Ohm's law. However, the impedance of human tissue may change with the change of current frequency, muscle tension, body temperature and other data. Therefore, taking the result of a single measurement as the determination result of the impedance of human tissue, and adjusting the power supply voltage of the neuromodulation product according to the determination result, will lead to the problem of inaccurate output current of the neuromodulation product. For example, if the measured human tissue impedance is too small, then when determining the power supply voltage required for neuromodulation, it may cause the obtained power supply voltage value to be too small, and the stimulation current cannot be accurately generated. If the measured impedance of human tissue is too large, it may cause waste of electrical energy in the neuromodulation product, especially for battery-powered neuromodulation products, the waste of electrical energy will directly affect the use time of the neuromodulation product. In addition, the impedance of human tissue can also be used to determine whether the electrode of the neuromodulation product has fallen off and whether there is fat or muscle deposition on the electrode surface of the implantable neuromodulation product.

[0056] In summary, accurate measurement of the impedance of human tissue is crucial to the regulation effect of neural regulation products. Based on this, the present disclosure provides a method for measuring the impedance of human tissue, which is applied to neural regulation products. Please refer to Figure 1 , according to a flowchart of a method for measuring impedance of human tissue shown in an exemplary embodiment, the flowchart may include the following steps:

[0057] S101, determining a plurality of initial supply voltages of a detection current based on a preset current value, wherein the detection current is a current output by a target electrode in contact with the human tissue and flowing through the human tissue.

[0058] In some embodiments, the preset current value refers to the current value of the detection current output by the electrodes at both ends of the neuromodulation product (e.g., a neurostimulator) under an ideal state. The current value of the detection current is generated by the main control unit in the human tissue impedance measurement system controlling the current source unit, specifically, the main control unit sends a control signal, and the digital-to-analog conversion unit provides a power supply voltage to the current source unit according to the control signal, and the current source unit generates a bidirectional symmetrical square wave or a single-phase square wave detection current according to the initial power supply voltage provided by the digital-to-analog conversion unit.

[0059] Based on the preset current value, the numerical range of the power supply voltage that the digital-to-analog conversion module needs to provide to the current source module can be determined. For example, when the preset current value is 1mA, the power supply voltage range is 3~4V. And multiple initial power supply voltages are determined at certain intervals. For example, when the power supply voltage range is 3~4V, the initial power supply voltage can be 3V, 3.2V, 3.4V, 3.6V, 3.8V, 4V. After determining multiple initial power supply voltages, multiple measurements of human tissue impedance are performed based on each initial power supply voltage and the preset current value, that is, multiple current data corresponding to each initial power supply voltage and the output voltage value corresponding to each current data are obtained.

[0060] S102, obtaining a plurality of current data corresponding to each initial supply voltage and an output voltage value corresponding to each current data, wherein the initial supply voltage is used to generate the detection current, and the output voltage value is a voltage value output to both ends of the human tissue.

[0061] Because for the same preset current value, the digital-to-analog conversion unit can provide multiple initial power supply voltages so that the current source unit generates a detection current that meets the preset current value. Therefore, in the case of the same preset current value, the detection current may have multiple initial power supply voltages. Through the current detection unit in the impedance measurement system of human tissue, multiple current data corresponding to each initial power supply voltage are obtained. Each current data includes at least the true current value, current frequency and pulse width of the detection current. The output voltage value refers to the voltage difference between the electrodes at both ends of the neuromodulation product. In one embodiment, based on the same preset current value, multiple current data can be obtained by controlling variables. For example, when the initial power supply voltage is 10V, the preset current value of the detection current is 1mA, the current frequency is 50Hz, and the pulse width is 500μs, 10 current data of the detection current are obtained, and when the initial power supply voltage is 15V, the preset current value of the detection current is 1mA, the current frequency is 60Hz, and the pulse width is 500μs, 10 current data of the detection current are obtained.

[0062] S103, determining the target impedance of the human tissue based on the real current values ​​and the corresponding output voltage values ​​in the multiple current data.

[0063] In some embodiments, the target impedance of the human tissue at this time is calculated based on Ohm's law according to the real current value and the output voltage value in the multiple current data of the detection current with the same preset current value.

[0064] In one embodiment, for multiple current data with the same preset current value, the same current frequency and the same pulse width and the output voltage value corresponding to each current data, multiple initial impedances are obtained, and then the target impedance of the human tissue measured by the detection current is determined based on the average value of the multiple initial impedances.

[0065] It should be noted that the real current value of the detection current refers to the current value of the detection current output by the current source unit collected by the current detection unit. The real current value of the detection current should be the same as the preset current value. The purpose of obtaining the real current value is to detect whether the detection current output by the current source unit is correct.

[0066] In the present disclosure, when measuring the impedance of human tissue, it can be detected by multiple preset current values. For each preset current value, a detection current corresponding to the preset current value can be generated by a current source unit at multiple initial supply voltages. For the same preset current value, it is also necessary to perform multiple detections for different current frequencies and different pulse widths, so as to obtain the impedance of human tissue corresponding to each detection current.

[0067] By performing multiple detections on the detection current, multiple current data and output voltage values ​​are obtained, and the impedance of the human tissue is determined based on the multiple current data and output voltage values, the accuracy of determining the impedance of the human tissue is improved.

[0068] By adopting multiple initial power supply voltages to power the current source unit and obtaining multiple current data corresponding to the same preset current value under different initial power supply voltages, the optimal power supply voltage corresponding to the detection current can be further determined after the human body impedance corresponding to the detection current is subsequently calculated, thereby improving the accuracy of generating the detection current.

[0069] In the embodiment of the present disclosure, after obtaining multiple current data and the output voltage data corresponding to each current data, the target impedance of the human tissue can be determined based on the real current value and the corresponding output voltage value in the multiple current data. For the specific process, see Figure 2 The flowchart shown includes the following steps:

[0070] S201 , determining a group of each current data according to the frequency or pulse width in the plurality of current data, wherein the frequency and pulse width of the current in each group of current data are the same.

[0071] S202, determining the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

[0072] After obtaining multiple current data, the group of each current data is determined according to the current frequency and pulse width in each current data. The actual current value, current frequency and pulse width of the detection current corresponding to the multiple current data in the same group are the same.

[0073] Then, according to the real current value of each current data in each set of data and its corresponding output voltage value, the impedance value of the human tissue detected by the current data is calculated.

[0074] By determining the target impedance of human tissue according to multiple current data of the same current value and the output voltage value corresponding to each current data, error interference in the impedance measurement process is reduced and the accuracy of human body impedance measurement is improved.

[0075] In the embodiment of the present disclosure, the process of determining the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value is as follows: Figure 3 The flowchart shown includes the following steps:

[0076] S301, determining multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data.

[0077] S302, screening the multiple initial impedances according to a preset error range.

[0078] S303, determining the target impedance of the human tissue based on the average value of the multiple initial impedances after screening.

[0079] Each current data includes the true current value, current frequency and pulse width of the detection current, and each current data has its corresponding output voltage value. Then, according to the true current value in each current data and the output voltage value corresponding to the current value, the initial impedance corresponding to the current data can be calculated. There are multiple current data in a set of data, so a set of data can calculate multiple initial impedances. The true current value, current frequency and pulse width of each current data in the same set of data are the same, so under normal circumstances, the values ​​of multiple initial impedances should also be the same. However, there will inevitably be unavoidable errors in actual measurements. For example, a slight change in the blood flow rate of human tissue will cause fluctuations in the initial impedance. Therefore, in order to accurately determine the impedance of human tissue, multiple initial impedances need to be screened.

[0080] When screening the initial impedance, the screening can be performed according to the preset error range. For example, when the difference between multiple initial impedances is within 1%, multiple initial impedances are determined to be usable values, or when the value of a certain initial impedance is higher than other values ​​by more than 100Ω, the initial impedance is filtered out. Alternatively, the highest value and the lowest value among the multiple initial impedances are removed to obtain the screened initial impedance.

[0081] After the initial impedance screening is completed, an average value of the multiple initial impedances after screening is calculated, and the average value is determined as the target impedance of the human tissue under the detection current.

[0082] By performing data analysis on multiple initial impedances, filtering out initial impedances with abnormal values, and determining the target impedance of human tissue based on the average value of the screened initial impedances, the error between the target impedance and the actual impedance of human tissue is reduced, and the accuracy of impedance measurement is improved. Furthermore, when adjusting the parameters of the Shenjiang regulation product based on the impedance of human tissue, the accuracy of parameter adjustment is improved.

[0083] In the embodiment of the present disclosure, after the impedance of the human tissue is detected, the power supply voltage required by the current source module can also be determined according to the impedance of the human tissue. For specific steps, see Figure 4 The flowchart shown may include the following steps:

[0084] S401, determining target current data and target output voltage value corresponding to the target impedance from among the plurality of current data and output voltage values.

[0085] S402 , determining, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value.

[0086] S403: If there are multiple candidate power supply voltages, determine the minimum power supply voltage among the candidate power supply voltages as the target power supply voltage.

[0087] First, among a plurality of current data of a set of current data and the output voltage corresponding to each current data, the target current data and the target output voltage value that can calculate the target impedance are determined. Since the target impedance is the average value of the plurality of initial impedances, there may not be a value that is completely consistent with the target impedance among the plurality of initial impedances. In this case, the current data and the output voltage value corresponding to the initial impedance with the smallest error with the target impedance can be determined as the target current data and the target output voltage value.

[0088] Then, because the initial supply voltage corresponding to each current data in the same set of current data is different, the candidate supply voltage corresponding to the target impedance can be determined according to the target current data and the target output voltage value. Because the same target current data and target output voltage value may correspond to multiple initial supply voltages, the candidate supply voltage may be one or more. When there are multiple candidate supply voltages, the minimum voltage among the candidate supply voltages is determined as the target supply voltage.

[0089] According to the target impedance value, the target supply voltage is determined among multiple initial supply voltages, which improves the accuracy of the supply voltage provided by the digital-to-analog conversion unit. When the same impedance detection result is obtained through multiple supply voltages, the smallest supply voltage among the multiple supply voltages is used as the target supply voltage, which saves the power of the detection system, saves the battery power of the neuromodulation product, and increases the usage time of the neuromodulation product.

[0090] In the disclosed embodiment, after the target impedance is detected, the connection state between the target electrode and the human tissue can be judged according to the target impedance of the human tissue, or the amount of fat accumulation in the human tissue can be determined according to the target impedance and the target correspondence, wherein the target correspondence is the correspondence between the impedance of the human tissue and the amount of fat accumulation.

[0091] First, obtain the standard impedance range of human tissue. For example, the impedance of muscle tissue is between several hundred ohms and several thousand ohms, and the impedance of skin tissue is between 10 kΩ and 100 kΩ. If the detected impedance of human tissue is not within the standard impedance range, it can be preliminarily determined that the contact between the target electrode of the neuromodulation product and the human tissue is poor, and there is a possibility that the target electrode has fallen off, so as to guide the staff to conduct further confirmation to avoid the failure of the neuromodulation product due to the electrode falling off, and the inability to accurately regulate the human tissue.

[0092] In another embodiment, because fat is a poor conductor, for implantable neuromodulatory products, if there is fat accumulation on the electrode surface, the detected target impedance value will be significantly different. Specifically, the amount of fat accumulation in human tissue can be determined through a pre-constructed target correspondence. It should be noted that the process of detecting the target impedance can be a continuous process. For example, after the neuromodulatory product is implanted in human tissue, the impedance of the human tissue is detected once a day. Each time, the impedance of the human tissue for the day can be determined by collecting multiple current data and output voltage values ​​of the same current. Then, with a cycle of one week, an impedance data record table is formed, and information such as the impedance change of the human tissue and the change of fat accumulation is determined based on the record table.

[0093] Corresponding to the embodiment of the impedance measurement method of human tissue described above, the present disclosure also provides an embodiment of an impedance measurement system for human tissue. For a system architecture diagram, see Figure 5 The system may include the following units:

[0094] The current source unit 501 is used to generate a detection current, wherein the detection current is a current output by a target electrode in contact with the human tissue and flows through the human tissue.

[0095] The current detection unit 502 is used to obtain a plurality of current data of the detection current based on a preset current value.

[0096] The voltage detection unit 503 is used to obtain the output voltage value corresponding to each current data; the output voltage value is the voltage value output to the two ends of the human tissue.

[0097] The main control unit 504 is used to determine the target impedance of the human tissue based on the real current values ​​and the corresponding output voltage values ​​in the multiple current data.

[0098] Among them, the current source unit 501 can realize its function through a logic gate circuit or a clock circuit to generate a detection current of a two-phase symmetrical square wave or a detection current of a single-phase square wave. The detection current generated by the current source unit 501 can be output to human tissue to achieve regulation or treatment of human tissue. In order to ensure that the current signal input to the human tissue is a standard two-phase symmetrical square wave detection current or a single-phase square wave signal, it is necessary to process the detection current signal output by the current source unit 501 through the DC isolation capacitor unit 505 to remove the DC component in the detection current. The DC isolation capacitor unit 505 is arranged on the two output channels of the current source unit 501, and can be specifically located between the output channel port and the motor connector. Then the detection current is output to human tissue through the connector and electrode unit 506. The connector and electrode unit 506 include components such as connectors, electrode wires, and electrode rings, which are used to connect the output of the current source unit 501 to human tissue.

[0099] The current detection unit 502 is connected to the current source unit 501 and is used to collect data of the detection current in the output channel of the current source unit, such as the current value, current frequency, pulse width and other data.

[0100] The voltage detection unit 503 is connected to the current source unit 501, and is used to collect the voltage difference between the current source unit 501 and the two ends of the human body tissue to obtain the output voltage value. The voltage detection unit 503 can be implemented by a resistor voltage divider circuit to accurately collect the voltage value output by the current source unit 501. It should be noted that because the resistor voltage divider circuit is designed with a resistor element with a large resistance value, and the output voltage value is collected according to the voltage division ratio between the resistor elements, in order to avoid the influence of the resistance value of the element in the main control unit 504 on the measurement of the voltage detection unit 503, it is necessary to design a voltage follower unit 507, i.e., a voltage follower, after the voltage detection unit 503 to reduce the signal interference between the main control unit 504 and the voltage detection unit 503, and play an isolation role.

[0101] After the current detection unit 501 obtains the current data and the voltage detection unit 504 obtains the output voltage value, the main control unit 504 needs to calculate the impedance of the human tissue based on the current data and the corresponding output voltage value. Because the current data or output voltage values ​​obtained by the current detection unit 501 and the voltage detection unit 504 are both analog signals, the main control unit 504 cannot process them directly, so it is necessary to set an analog-to-digital conversion unit 508 before the main control unit 504, and convert the current data and the output voltage value into digital signals that can be processed by the main control unit 504 through the analog-to-digital conversion unit 508. It should be noted that the analog-to-digital conversion unit 508 can be a separate ADC chip, or it can be an ADC unit integrated internally in the MCU.

[0102] After the main control unit 504 determines the target impedance of the human tissue based on the actual current values ​​and the corresponding output voltage values ​​in the multiple current data, it can further determine the target power supply voltage corresponding to the target impedance, and output a digital signal carrying the target power supply voltage information to the digital-to-analog conversion unit 509, and power the current source unit 501 through the digital-to-analog conversion unit 509, so that the current source unit 501 can generate a detection current.

[0103] It should be noted that in order to enable each component in the measurement system to work normally, a power management unit 510 is also provided in the detection system to provide DC voltage to each unit in the measurement system, which may specifically include the DC working voltage required by the main control unit 504, the high-voltage DC voltage and reference voltage required by the current source unit 501, etc.

[0104] The detection current is detected multiple times through the human body impedance measurement system to obtain multiple current data and output voltage values, and the impedance of the human body tissue is determined based on the multiple current data and output voltage values, thereby improving the accuracy of determining the impedance of the human body tissue.

[0105] In one embodiment, when the current detection unit 501 obtains a plurality of current data based on a preset current value, it includes:

[0106] Based on the preset current value, determining a plurality of initial supply voltages of the detection current;

[0107] A plurality of current data corresponding to each initial supply voltage is obtained.

[0108] In one embodiment, when the main control unit 504 determines the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the plurality of current data, it includes:

[0109] Determining a group of each current data according to the frequency or pulse width in the plurality of current data, wherein the frequency and pulse width of the current in each group of current data are the same;

[0110] The target impedance of the human tissue is determined according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

[0111] In one embodiment, when the main control unit 504 determines the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value, it includes:

[0112] Determine multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data;

[0113] Screening the multiple initial impedances according to a preset error range;

[0114] The target impedance of the human tissue is determined based on an average value of the multiple initial impedances after screening.

[0115] In one embodiment, the main control unit 504 is further used for:

[0116] Determine, among the plurality of current data and output voltage values, target current data and target output voltage value corresponding to the target impedance;

[0117] Determine, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value;

[0118] If there are multiple candidate power supply voltages, the minimum power supply voltage among the candidate power supply voltages is determined as the target power supply voltage.

[0119] In one embodiment, the main control unit 504 is further used for:

[0120] The connection state between the target electrode and the human tissue is determined according to the target impedance.

[0121] In one embodiment, the main control unit 504 is further used for:

[0122] The amount of fat accumulation in the human tissue is determined based on the target impedance and the target corresponding relationship, wherein the target corresponding relationship is the corresponding relationship between the impedance of the human tissue and the amount of fat accumulation.

[0123] The present disclosure also provides an electronic device, which includes the aforementioned human body impedance measurement system, and can accurately measure the impedance of human tissue. The electronic device can be a deep brain stimulator, a transcranial magnetic stimulator, a spinal cord stimulator, a neuromuscular stimulator, and other neuromodulation products.

[0124] Corresponding to the above-mentioned embodiment of the method for measuring human body impedance, the present disclosure also provides an embodiment of a device for measuring human body impedance.

[0125] Please refer to Figure 6 As shown in the block diagram, the device for measuring human body impedance comprises:

[0126] A first determination module 601 is used to determine a plurality of initial supply voltages of a detection current based on a preset current value, wherein the detection current is a current output by a target electrode in contact with the human tissue and flowing through the human tissue;

[0127] An acquisition module 602 is used to acquire a plurality of current data corresponding to each initial supply voltage and an output voltage value corresponding to each current data, wherein the initial supply voltage is used to generate the detection current, and the output voltage value is a voltage value output to both ends of the human tissue;

[0128] The second determination module 603 is used to determine the target impedance of the human tissue based on the real current values ​​and the corresponding output voltage values ​​in the multiple current data.

[0129] In the embodiment of the present disclosure, the second determining module 603 is used to:

[0130] Determining a group of each current data according to the frequency or pulse width in the plurality of current data, wherein the frequency and pulse width of the current in each group of current data are the same;

[0131] The target impedance of the human tissue is determined according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

[0132] In the embodiment of the present disclosure, the second determining module 603 is used to:

[0133] Determine multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data;

[0134] Screening the multiple initial impedances according to a preset error range;

[0135] The target impedance of the human tissue is determined based on an average value of the multiple initial impedances after screening.

[0136] In the embodiment of the present disclosure, the device further includes:

[0137] A third determination module, configured to determine, from among the plurality of current data and output voltage values, target current data and target output voltage value corresponding to the target impedance;

[0138] a fourth determining module, configured to determine, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value;

[0139] The fifth determining module is configured to determine a minimum supply voltage among the candidate supply voltages as a target supply voltage if there are multiple candidate supply voltages.

[0140] In the embodiment of the present disclosure, the device further includes:

[0141] A judgment module, used for judging the connection state between the target electrode and the human tissue according to the target impedance;

[0142] The sixth determination module is used to determine the amount of fat accumulation in the human tissue according to the target impedance and the target corresponding relationship, wherein the target corresponding relationship is the corresponding relationship between the impedance of the human tissue and the amount of fat accumulation.

[0143] The implementation process of the functions and effects of each unit in the above-mentioned device is specifically described in the implementation process of the corresponding steps in the above-mentioned method, and will not be repeated here.

[0144] For the device embodiments, since they basically correspond to the method embodiments, the relevant parts can refer to the partial description of the method embodiments. The device embodiments described above are only schematic, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the disclosed solution. A person of ordinary skill in the art can understand and implement it without paying any creative work.

[0145] Thus, specific embodiments of the subject matter have been described. Other embodiments are within the scope of the appended claims. In some cases, the actions recited in the claims can be performed in a different order and still achieve the desired results. In addition, the processes depicted in the drawings do not necessarily require the particular order or sequential order shown to achieve the desired results. In some implementations, multitasking and parallel processing may be advantageous.

[0146] The above description is only a preferred embodiment of the present disclosure and is not intended to limit the present disclosure. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present disclosure shall be included in the scope of protection of the present disclosure.

Claims

1. A method for measuring impedance of human tissue, characterized in that: The method comprises: Based on the preset current value, determining a plurality of initial supply voltages for a detection current, wherein the detection current is a current output by a target electrode in contact with human tissue, and the initial supply voltage is used to generate the detection current; Acquire multiple current data corresponding to each initial power supply voltage and an output voltage value corresponding to each current data, wherein the output voltage value is a voltage value output to both ends of the human tissue, and each current data at least includes a real current value, a current frequency, and a pulse width of the detection current; Determine the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the multiple current data corresponding to each initial supply voltage; Determine, among the plurality of current data and output voltage values, target current data and target output voltage value corresponding to the target impedance; Determine, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value; If there are multiple candidate power supply voltages, the minimum power supply voltage among the candidate power supply voltages is determined as the target power supply voltage.

2. The method according to claim 1, characterized in that The step of determining the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the plurality of current data corresponding to each initial supply voltage comprises: Determine the group of each current data according to the frequency or pulse width in the multiple current data corresponding to each initial supply voltage, wherein the frequency and pulse width of the current in each group of current data are the same; The target impedance of the human tissue is determined according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

3. The method according to claim 2, characterized in that The step of determining the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value comprises: Determine multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data; Screening the multiple initial impedances according to a preset error range; The target impedance of the human tissue is determined based on an average value of the multiple initial impedances after screening.

4. The method according to claim 1, characterized in that: The method further comprises: Determining a connection state between the target electrode and the human tissue according to the target impedance; Alternatively, the amount of fat accumulation in the human tissue is determined based on the target impedance and the target corresponding relationship, wherein the target corresponding relationship is the corresponding relationship between the impedance of the human tissue and the amount of fat accumulation.

5. A human tissue impedance measurement system, characterized in that: The system comprises: A current source unit, configured to generate a detection current according to an initial supply voltage, wherein the detection current is a current output by a target electrode in contact with the human tissue and flowing through the human tissue; A current detection unit, used for acquiring a plurality of current data of the detection current based on a preset current value, each current data at least including a real current value, a current frequency and a pulse width of the detection current; A voltage detection unit, used to obtain an output voltage value corresponding to each current data; the output voltage value is a voltage value output to both ends of the human tissue; A main control unit, configured to determine a target impedance of the human tissue based on real current values ​​and corresponding output voltage values ​​in the plurality of current data; The main control unit is also used for: Determine, among the plurality of current data and output voltage values, target current data and target output voltage value corresponding to the target impedance; Determine, among a plurality of initial supply voltages corresponding to the preset current value, a candidate supply voltage corresponding to the target current data and the target output voltage value; If there are multiple candidate power supply voltages, the minimum power supply voltage among the candidate power supply voltages is determined as the target power supply voltage.

6. The system according to claim 5, characterized in that When the main control unit determines the target impedance of the human tissue based on the real current value and the corresponding output voltage value in the plurality of current data, the main control unit includes: Determining a group of each current data according to the frequency or pulse width in the plurality of current data, wherein the frequency and pulse width of the current in each group of current data are the same; The target impedance of the human tissue is determined according to the real current value in each set of current data and the output voltage value corresponding to each real current value.

7. The system according to claim 6, characterized in that When the main control unit determines the target impedance of the human tissue according to the real current value in each set of current data and the output voltage value corresponding to each real current value, it includes: Determine multiple initial impedances of human tissue based on multiple real current values ​​in each set of current data and an output voltage value corresponding to each current data; Screening the multiple initial impedances according to a preset error range; The target impedance of the human tissue is determined based on an average value of the multiple initial impedances after screening.

8. An electronic device, characterized in that: The electronic device comprises the human tissue impedance measurement system according to any one of claims 5 to 7.

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