Low-frequency sinusoidal magnetic nerve control device and related products

Abstract

The present application discloses a low-frequency sinusoidal magnetic nerve regulation device and related products. When low-frequency sinusoidal magnetic nerve regulation is performed on the target area of ​​the subject, the central control unit obtains input parameters; based on the stimulation intensity ratio and the stimulation intensity threshold, the target stimulation intensity is determined; based on the target stimulation intensity and the stimulation parameters, the initial low-frequency sinusoidal stimulation current is sent to the magnetic field coil through the current generating circuit; the magnetic field coil generates a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current; the magnetic field intensity sensor detects the initial magnetic field intensity of the target area; the central control unit determines the induced electric field intensity generated in the target area; if the induced electric field intensity is different from the target stimulation intensity, the target low-frequency sinusoidal stimulation current is determined based on the target stimulation intensity; the target low-frequency sinusoidal stimulation current is sent to the magnetic field coil through the current generating circuit, so that the induced electric field intensity of the target area is the target stimulation intensity. The present application is conducive to improving the accuracy of low-frequency sinusoidal magnetic nerve regulation.

Description

Technical Field

[0001] The present application relates to the field of biomedical engineering, and in particular to a low-frequency sinusoidal magnetic nerve regulation device and related products. Background Art

[0002] With the development of biomedicine and biotechnology, magnetic neuromodulation technology is increasingly being used in the treatment of brain diseases. Magnetic neuromodulation technology is a medical technology that uses a magnetic field generated by alternating current to act on the central or peripheral nervous system of the subject, generating current pulses in the central or peripheral nervous system of the subject, thereby regulating the excitability of the nervous system and alleviating or treating disease symptoms.

[0003] The stimulation produced by magnetic neuromodulation on the subject's brain is usually divided into high-frequency stimulation and low-frequency stimulation. High-frequency stimulation is used to excite the subject's brain neurons, and low-frequency stimulation is used to inhibit the excitability of the subject's brain neurons. In the current magnetic neuromodulation technology, low-frequency stimulation is usually simulated by controlling the on and off of the high-frequency magnetic field generated by the magnetic field coil, and the generated magnetic field is a static magnetic field. In the actual treatment of brain diseases, low-frequency sinusoidal magnetic neuromodulation has a good effect in inhibiting the excitability of the subject's brain neurons.

[0004] Since the stimulation intensity of the low-frequency sinusoidal magnetic nerve regulation device is a pre-set stimulation intensity, when performing low-frequency sinusoidal magnetic nerve regulation on the subject, there may be deviations in the stimulation intensity when stimulating the subject, resulting in lower accuracy of the low-frequency sinusoidal magnetic nerve regulation on the subject. Summary of the invention

[0005] In order to solve the above-mentioned problems existing in the prior art, the embodiments of the present application provide a low-frequency sinusoidal magnetic nerve regulation device and related products. The induced electric field strength of the target area of ​​the subject is determined by detecting the magnetic field strength of the low-frequency sinusoidal magnetic field generated by the magnetic field coil. When the induced electric field strength is different from the target stimulation intensity, the target low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity is sent to the magnetic field coil through the current generating circuit, thereby improving the accuracy of low-frequency sinusoidal magnetic nerve regulation on the subject.

[0006] In a first aspect, an embodiment of the present application provides a low-frequency sinusoidal magnetic nerve regulation device, the low-frequency sinusoidal magnetic nerve regulation device comprising: a central control unit, a current generating circuit, a magnetic field coil and a magnetic field intensity sensor;

[0007] When low-frequency sinusoidal magnetic nerve regulation is performed on the target area of ​​the subject, the central control unit is used to obtain input parameters, and the input parameters include: stimulation intensity ratio and stimulation parameters;

[0008] Determining a target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold;

[0009] Based on the target stimulation intensity and the stimulation parameters, sending an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil through the current generating circuit;

[0010] The magnetic field coil is used to generate a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current;

[0011] The magnetic field intensity sensor is used to detect the initial magnetic field intensity of the low-frequency sinusoidal magnetic field in the target area;

[0012] The central control unit is used to determine the induced electric field strength generated by the initial magnetic field strength in the target area; if the induced electric field strength is different from the target stimulation intensity, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined based on the target stimulation intensity; the target low-frequency sinusoidal stimulation current is sent to the magnetic field coil through the current generating circuit, so that the induced electric field strength generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area is the target stimulation intensity.

[0013] In a second aspect, an embodiment of the present application provides a low-frequency sinusoidal magnetic nerve regulation method, the method is applied to a low-frequency sinusoidal magnetic nerve regulation device, the low-frequency sinusoidal magnetic nerve regulation device comprising: a central control unit, a current generating circuit, a magnetic field coil and a magnetic field strength sensor;

[0014] The method comprises:

[0015] When performing low-frequency sinusoidal magnetic nerve regulation on the target area of ​​the subject, input parameters are obtained, and the input parameters include: stimulation intensity ratio and stimulation parameters;

[0016] Determining a target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold;

[0017] Based on the target stimulation intensity and the stimulation parameters, sending an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil through the current generating circuit;

[0018] generating a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current;

[0019] Detecting the initial magnetic field strength of the low-frequency sinusoidal magnetic field in the target area;

[0020] Determine the induced electric field strength generated by the initial magnetic field strength in the target area; if the induced electric field strength is different from the target stimulation intensity, determine the target low-frequency sinusoidal stimulation current of the magnetic field coil based on the target stimulation intensity; send the target low-frequency sinusoidal stimulation current to the magnetic field coil through the current generating circuit, so that the induced electric field strength generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area is the target stimulation intensity.

[0021] In a third aspect, an embodiment of the present application provides an electronic device, comprising: a processor and a memory, the processor being connected to the memory, the memory being used to store a computer program, and the processor being used to execute the computer program stored in the memory, so that the electronic device executes the method described in the second aspect.

[0022] In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and the computer program is executed by a processor to implement the method described in the second aspect.

[0023] In a fifth aspect, an embodiment of the present application provides a computer program product, wherein the computer program product includes a computer program, and the computer program is executed by a processor to implement the method described in the second aspect.

[0024] Implementing the embodiments of the present application has the following beneficial effects:

[0025] In an embodiment of the present application, when low-frequency sinusoidal magnetic nerve regulation is performed on the target area of ​​the subject, the central control unit obtains input parameters, including the stimulation intensity ratio and the stimulation parameters. Then, the central control unit can determine the target stimulation intensity based on the stimulation intensity ratio and the pre-determined stimulation intensity threshold. Further, based on the target stimulation intensity and the stimulation parameters, the central control unit can send an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil through a current generating circuit. Then, the magnetic field coil can generate a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current, and detect the initial magnetic field intensity of the low-frequency sinusoidal magnetic field in the target area through a magnetic field intensity sensor. The central control unit can determine the induced electric field intensity generated by the initial magnetic field intensity in the target area of ​​the subject. If the induced electric field intensity is different from the target stimulation intensity, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined based on the target stimulation intensity. Finally, the target low-frequency sinusoidal stimulation current is sent to the magnetic field coil through the current generating circuit, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area of ​​the subject is the target stimulation intensity. Thus, by detecting the initial magnetic field strength of the low-frequency sinusoidal magnetic field generated by the magnetic field coil, the induced electric field strength of the initial magnetic field strength in the target area is determined, so that when the induced electric field strength is different from the target stimulation strength, the initial low-frequency sinusoidal stimulation current of the magnetic field coil can be adjusted to the target low-frequency sinusoidal stimulation current. Based on this, when the corresponding relationship between the target stimulation intensity and the initial low-frequency sinusoidal stimulation current is determined in advance, the low-frequency sinusoidal magnetic nerve regulation device of the present application can dynamically adjust the low-frequency sinusoidal stimulation current of the magnetic field coil based on the induced electric field strength and the target stimulation intensity generated in the target area, so that the induced electric field strength generated in the target area is the target stimulation intensity, thereby improving the accuracy of low-frequency sinusoidal magnetic nerve regulation on the subject. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0027] Figure 1 A schematic diagram of an application scenario of a low-frequency sinusoidal magnetic nerve control device provided in an embodiment of the present application;

[0028] Figure 2 A schematic diagram of another application scenario of a low-frequency sinusoidal magnetic nerve control device provided in an embodiment of the present application;

[0029] Figure 3 A schematic diagram of the structure of a low-frequency sinusoidal magnetic nerve control device provided in an embodiment of the present application;

[0030] Figure 4 A schematic diagram of the structure of another low-frequency sinusoidal magnetic nerve regulation device provided in an embodiment of the present application;

[0031] Figure 5 A schematic diagram of the waveform of an initial low-frequency sinusoidal stimulation current provided in an embodiment of the present application;

[0032] Figure 6 A schematic diagram of the structure of another low-frequency sinusoidal magnetic nerve regulation device provided in an embodiment of the present application;

[0033] Figure 7 A schematic diagram of the structure of another low-frequency sinusoidal magnetic nerve regulation device provided in an embodiment of the present application;

[0034] Figure 8 A schematic diagram of a flow chart of a low-frequency sinusoidal magnetic nerve control method provided in an embodiment of the present application;

[0035] Fig. 9 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0037] The terms "first", "second", "third" and "fourth" etc. in the specification and claims of the present application and the drawings are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0038] Reference to "embodiments" herein means that a particular feature, result, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0039] First, see Figure 1 and Figure 2 , Figure 1 A schematic diagram of an application scenario of a low-frequency sinusoidal magnetic nerve control device provided in an embodiment of the present application, Figure 2 A schematic diagram of another application scenario of a low-frequency sinusoidal magnetic nerve control device provided in an embodiment of the present application. Figure 1 As shown, when a subject is subjected to low-frequency sinusoidal magnetic neuromodulation, the magnetic field coil of the low-frequency sinusoidal magnetic neuromodulation device is placed on the side of the subject's brain. Then, the user sets input parameters on the low-frequency sinusoidal magnetic neuromodulation device, which may include: stimulation frequency, stimulation intensity, stimulation duration, etc. After the device is started, the low-frequency sinusoidal magnetic neuromodulation device generates a low-frequency sinusoidal stimulation current corresponding to the input parameters based on the set input parameters. The low-frequency sinusoidal stimulation current flows through the magnetic field coil, and the magnetic field coil generates a Figure 1 The low-frequency sinusoidal magnetic field shown. The low-frequency sinusoidal magnetic field generates an induced electric field in the target area of ​​the subject's brain, so as to stimulate the target area of ​​the subject's brain with an induced electric field intensity corresponding to the input parameters, causing current conduction between brain neurons, thereby affecting the action potential of neurons to regulate the subject's neural activity. Among them, the target area is the area where the subject's brain is subjected to low-frequency sinusoidal magnetic neural regulation.

[0040] And in Figure 2 In the application scenario shown, the magnetic field coil of the low-frequency sinusoidal magnetic nerve regulation device surrounds the subject's brain. When the subject is subjected to low-frequency sinusoidal magnetic nerve regulation, the user sets the input parameters, and the low-frequency sinusoidal magnetic nerve regulation device generates a low-frequency sinusoidal stimulation current corresponding to the input parameters based on the input parameters. The low-frequency sinusoidal stimulation current flows through the magnetic field coil, and the magnetic field coil generates Figure 2 The low-frequency sinusoidal magnetic field shown in the figure stimulates the entire brain of the subject, and the stimulation intensity is the stimulation intensity corresponding to the input parameter, thereby achieving magnetic neural regulation of the entire brain of the subject.

[0041] It should be noted that Figure 1 In the application scenario, the low-frequency sinusoidal magnetic field generated starts from the center of the magnetic field coil, and the magnetic field strength gradually decreases from near to far. Figure 2 In the application scenario, the low-frequency sinusoidal magnetic field generated has the same magnetic field strength everywhere in the subject's brain.

[0042] It should be noted that magnetic neuromodulation includes three modes, namely transcranial magnetic stimulation, static magnetic field therapy and magnetic therapy technology. According to the frequency of magnetic neuromodulation on the subject, magnetic neuromodulation can be divided into high-frequency magnetic neuromodulation and low-frequency magnetic neuromodulation. Among them, high-frequency magnetic neuromodulation can be used to excite brain neurons, and low-frequency magnetic neuromodulation can be used to inhibit the excitability of brain neurons. In transcranial magnetic stimulation, the stimulation intensity and stimulation frequency generated are both high stimulation intensity and stimulation frequency, and the probability of brain neurons responding to high-frequency stimulation is low. Therefore, transcranial magnetic stimulation cannot meet the low-frequency magnetic neuromodulation needs of specific patients. In static magnetic field therapy, the magnetic field generated by the magnetic field coil is a static magnetic field, and the magnetic field coil must be placed in a specific area of ​​the subject's brain, and the user experience is poor. In magnetic therapy technology, the low-frequency magnetic field is usually simulated by controlling the on and off of the generated high-frequency magnetic field. Therefore, traditional magnetic neuromodulation devices cannot effectively achieve low-frequency sinusoidal magnetic neuromodulation of subjects.

[0043] It should be noted that the stimulation intensity of the existing low-frequency sinusoidal magnetic nerve regulation devices is a pre-set stimulation intensity. The stimulation intensity is obtained by measuring the stimulation intensity of the subject. When the subject is subjected to low-frequency sinusoidal magnetic nerve regulation, the actual stimulation intensity generated in the target area of ​​the subject may deviate from the pre-set stimulation intensity, resulting in a low accuracy of the low-frequency sinusoidal magnetic nerve regulation of the subject.

[0044] In order to solve the above problems existing in the prior art, the present application provides a low-frequency sinusoidal magnetic nerve regulation device. The low-frequency sinusoidal magnetic nerve regulation device can determine the induced electric field strength of the magnetic field strength in the target area of ​​the subject by detecting the magnetic field strength of the low-frequency sinusoidal magnetic field generated by the magnetic field coil. When the induced electric field strength is different from the preset target stimulation strength, the target low-frequency sinusoidal stimulation current corresponding to the target stimulation strength is sent to the magnetic field coil through the current generation circuit, thereby improving the accuracy of low-frequency sinusoidal magnetic nerve regulation on the subject.

[0045] For example, see Figure 3 , Figure 3 This is a schematic diagram of the structure of a low-frequency sinusoidal magnetic nerve control device provided in an embodiment of the present application. Figure 3 As shown, the low-frequency sinusoidal magnetic nerve regulation device 200 includes: a central control unit 201, a current generating circuit 202, a magnetic field coil 203 and a magnetic field strength sensor 204.

[0046] In the embodiment of the present application, a first end of the central control unit 201 is connected to a first end of the current generating circuit 202, and a second end of the central control unit 201 is connected to a first end of the magnetic field intensity sensor 204. A second end of the current generating circuit 202 is connected to a first end of the magnetic field coil 203. A second end of the magnetic field coil 203 is connected to a second end of the magnetic field intensity sensor 204.

[0047] The central control unit 201 may be, for example, a processor and controller with functions such as data storage, data processing, and communication interaction, or a chip integrating a processor and a controller, including a central processing unit (Central Processing Unit), a graphics processing unit (Graphics Processing Unit, GPU), a single-chip microcomputer (Single-Chip Microcomputer, SCM), a field programmable gate array (Field Programmable Gate Array, FPGA), etc. The central control unit 201 may also be a communication interaction device integrating a processor, a controller, and a chip, including: an electronic computer, an intelligent communication device, and the like.

[0048] Exemplarily, when low-frequency sinusoidal magnetic nerve regulation is performed on the target area of ​​the subject, the central control unit 201 obtains input parameters.

[0049] In the embodiment of the present application, the input parameters may include, for example, stimulation intensity ratio and stimulation parameters. The stimulation intensity ratio represents the ratio of the target stimulation intensity to the stimulation intensity threshold, the target stimulation intensity is the induced electric field intensity generated in the target area of ​​the subject set by the user, and the stimulation intensity threshold is the minimum induced electric field intensity required to produce changes in brain neurons measured in advance for the subject. The stimulation parameters may include, for example, stimulation frequency, total stimulation duration, single stimulation duration, and interval time. By adjusting the stimulation parameters, the low-frequency sinusoidal magnetic field generated by the magnetic field coil 203 can be adjusted.

[0050] Specifically, when the central control unit 201 is a processor, a controller, and a chip, the central control unit 201 can be connected to an operable display device, and the user can set input parameters on the operable display device, and the central control unit 201 can obtain the input parameters from the operable display device. When the central control unit 201 is a communication interaction device, the user can set the input parameters directly on the central control unit 201. Optionally, the user also needs to set the distance between the center point of the target area and the center point of the magnetic field coil 203, and the central control unit 201 can determine the position of the target area based on the distance between the center point of the target area and the center point of the magnetic field coil 203. After obtaining the input parameters, the central control unit 201 can determine the target stimulation intensity of the target area of ​​the subject based on the input parameters.

[0051] Exemplarily, the central control unit 201 determines the target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold.

[0052] In the embodiment of the present application, the stimulation intensity threshold is the lowest evoked electric field intensity that causes changes in the brain neurons of the subject, and the stimulation intensity threshold needs to be measured in advance for the subject. Since the stimulation intensity ratio represents the ratio of the target stimulation intensity to the stimulation intensity threshold, the central control unit 201 can use the product of the stimulation intensity ratio and the stimulation intensity threshold as the target stimulation intensity.

[0053] Exemplarily, the input parameters also include: initial stimulation intensity. When determining the stimulation intensity threshold, the central control unit 201 periodically sends an initial low-frequency sinusoidal stimulation current corresponding to the initial stimulation intensity to the magnetic field coil through the current generating circuit based on the initial stimulation intensity, so that the low-frequency sinusoidal magnetic field generated by the magnetic field coil generates multiple stimulations in the occipital lobe of the subject's back brain; the central control unit 201 obtains the number of responses of the subject to the multiple stimulations; if the number of responses to the multiple stimulations is less than the first threshold, the central control unit 201 increases the initial stimulation intensity by a preset intensity to obtain a new initial stimulation intensity; the central control unit 201 determines the number of responses of the subject to the new multiple stimulations based on the new initial stimulation intensity, until the number of responses corresponding to the new initial stimulation intensity is greater than or equal to the first threshold; the central control unit 201 uses the new initial stimulation intensity as the stimulation intensity threshold.

[0054] In the embodiment of the present application, the initial low-frequency sinusoidal stimulation current of each cycle includes: a low-frequency sinusoidal stimulation current of a preset duration and an interval time. The initial stimulation intensity is the lowest stimulation intensity when the stimulation intensity threshold is measured for the subject.

[0055] Specifically, the central control unit 201 generates an initial sinusoidal stimulation current corresponding to the initial stimulation intensity through the current generating circuit 202 based on the initial stimulation intensity. Figure 4 As shown, the current generating circuit 202 may include, for example, a power supply 301, a filtering and soft starting circuit 302, a power factor correction circuit 303, a current modulation circuit 304, and a converter 305. The output end of the power supply 301 is connected to the input end of the filtering and soft starting circuit 302, and the output end of the filtering and soft starting circuit 302 is connected to the input end of the power factor correction circuit 303. The first end of the current modulation circuit 304 is connected to the output end of the power factor correction circuit 303, the second end of the current modulation circuit 304 is connected to the input end of the converter 305, and the third end of the current modulation circuit 304, as the first end of the current generating circuit 202, is connected to the first end of the central control unit 201. The output end of the converter 305, as the second end of the current generating circuit 202, is connected to the first end of the magnetic field coil 203.

[0056] Exemplarily, in the current generating circuit 202, the power supply 301 is used to provide input current for the current generating circuit 202, and the filtering and soft starting circuit 302 will filter the input current to filter out high-frequency noise and harmonic current in the input current. At the same time, the filtering and soft starting circuit 302 can suppress the surge current in the input current after the power supply 301 is started, so that the input current reaches a stable state. The power factor correction circuit 303 can perform power factor correction on the input current to eliminate the phase shift of the input current, and at the same time, the power factor correction circuit 303 can suppress the distortion of the input current. Optionally, the distorted input current can be modulated into a sinusoidal input current by a switching converter. The input current enters the current modulation circuit 304 after filtering, soft starting and power factor correction. The current modulation circuit 304 obtains the current parameters of the starting low-frequency sinusoidal stimulation current corresponding to the starting stimulation intensity from the central control unit 201, and the current parameters include: frequency and amplitude. Then, the current modulation circuit 304 modulates the starting low-frequency sinusoidal stimulation current based on the current parameters of the starting low-frequency sinusoidal stimulation current. In addition, the central control unit 201 can control the on and off of the current modulation circuit 304 so that the starting low-frequency sinusoidal stimulation current modulated by the current modulation circuit 304 is a periodic low-frequency sinusoidal current. The starting low-frequency sinusoidal stimulation current of each cycle includes a low-frequency sinusoidal stimulation current of a preset duration and an interval time. During each interval time, the current modulation circuit 304 is turned off by the central control unit 201, and the starting low-frequency sinusoidal stimulation current is 0. Finally, the starting low-frequency sinusoidal stimulation current is converted by the converter 305 and sent to the magnetic field coil 203. Optionally, the converter 305 can be an AC converter for correcting the frequency and phase of the starting low-frequency sinusoidal stimulation current, so that the current generating circuit 202 stably sends the starting low-frequency sinusoidal stimulation current to the magnetic field coil.

[0057] Next, the initial low-frequency sinusoidal stimulation current flows through the magnetic field coil 203, so that the low-frequency sinusoidal magnetic field of the magnetic field coil 203 generates multiple stimulations in the occipital lobe of the subject's back head, and the induced electric field intensity generated in the occipital lobe of the subject's back head is the initial stimulation intensity. The interval between each stimulation is the interval between each cycle of the initial low-frequency sinusoidal stimulation current. For example, Figure 4 As shown, the third end of the central control unit 201 is also connected to the output end of the threshold determination module 205. The threshold determination module 205 can be a response button. The subject can respond to the generated stimulation through the threshold determination module 205 at each interval. For example, when the low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current generates 5 stimulations in the occipital lobe of the subject's back brain, and the interval between each stimulation is 5s, when the subject can feel the bright light after closing his eyes, the subject needs to respond to the bright light stimulation through the threshold determination module 205 within the interval of 5s.

[0058] It should be noted that since the stimulation intensity threshold is the minimum stimulation intensity that causes changes in the subject's brain neurons, and the most sensitive area of ​​brain neurons is the occipital lobe, when determining the stimulation intensity threshold, the subject's occipital lobe needs to be stimulated multiple times to determine the minimum stimulation intensity that causes changes in the occipital lobe neurons, that is, the stimulation intensity threshold. When the neurons in the occipital lobe receive stimulation that is higher than the stimulation intensity threshold, the subject can feel bright light. Therefore, the stimulation intensity threshold of the subject can be determined by stimulating the subject with different stimulation intensities.

[0059] After the multiple stimulations corresponding to the initial stimulation intensity are completed, the central control unit 201 obtains the number of responses of the subject to the multiple stimulations. If the number of responses to the multiple stimulations is less than the first threshold, it means that the initial stimulation intensity is not the minimum stimulation intensity that causes changes in the subject's brain neurons. At this time, the central control unit 201 will increase the initial stimulation intensity by a preset intensity to obtain a new initial stimulation intensity. Among them, the first threshold and the preset intensity can be pre-set based on the measurement accuracy of the stimulation intensity threshold. Based on the new initial stimulation intensity, the magnetic field coil 203 generates a new low-frequency sinusoidal magnetic field, and generates new multiple stimulations in the occipital lobe of the subject's back brain. The central control unit 201 obtains the number of responses of the subject to the new multiple stimulations, and continues to execute the above method until the number of responses corresponding to the new initial stimulation intensity is greater than or equal to the first threshold. The initial stimulation intensity when the number of responses is greater than or equal to the first threshold is used as the stimulation intensity threshold.

[0060] It can be seen that the central control unit 201 periodically sends the starting low-frequency sinusoidal current corresponding to the starting stimulation intensity to the magnetic field coil 203 through the current generating circuit 202, generating multiple stimulations in the occipital lobe of the subject's back brain. Then, the number of responses of the subject to the multiple stimulations is obtained. When the number of responses is less than the first threshold, the starting stimulation intensity is increased by a preset intensity and the subject is stimulated multiple times until the number of responses of the subject to the multiple stimulations is greater than or equal to the first threshold. The starting stimulation intensity when the number of responses is greater than or equal to the first threshold is used as the stimulation intensity threshold. Thus, the stimulation intensity threshold of the subject can be determined, so that the target stimulation intensity can be determined based on the stimulation intensity threshold and the stimulation intensity ratio, so as to perform low-frequency sinusoidal magnetic nerve regulation corresponding to the target stimulation intensity on the subject, thereby improving the accuracy of low-frequency sinusoidal magnetic nerve regulation.

[0061] Furthermore, based on the target stimulation intensity and stimulation parameters, the central control unit 201 sends an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil 203 through the current generating circuit 202 .

[0062] In the embodiment of the present application, the stimulation parameters include: stimulation frequency, total stimulation duration, single stimulation duration and interval time. Specifically, based on the target stimulation intensity and stimulation parameters, when the initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity is sent to the magnetic field coil 203 through the current generating circuit 202, the central control unit 201 obtains the amplitude of the low-frequency sinusoidal stimulation current when the occipital lobe of the subject's back brain is stimulated with the target stimulation intensity; the central control unit 201 uses the amplitude as the current amplitude of the initial low-frequency sinusoidal stimulation current; the central control unit 201 uses the stimulation frequency as the current frequency of the initial low-frequency sinusoidal stimulation current; based on the current amplitude, current frequency, single stimulation duration and interval time, the central control unit 201 continuously sends the initial low-frequency sinusoidal stimulation current of the total stimulation duration to the magnetic field coil 203 through the current generating circuit 202.

[0063] The initial low-frequency sinusoidal stimulation current includes a plurality of stimulation cycles, and each stimulation cycle includes the initial low-frequency sinusoidal stimulation current of a single stimulation duration and an interval time.

[0064] Specifically, the central control unit 201 obtains the amplitude of the low-frequency sinusoidal stimulation current when the occipital lobe of the subject's back head is stimulated with the target stimulation intensity. Optionally, the central control unit 201 may obtain the amplitude of the starting low-frequency sinusoidal stimulation current corresponding to the stimulation intensity threshold. Then, based on the ratio of the target stimulation intensity and the stimulation intensity threshold, the amplitude of the starting low-frequency sinusoidal stimulation current is proportionally adjusted, and the adjusted amplitude is used as the amplitude of the low-frequency sinusoidal stimulation current when the occipital lobe of the subject's back head is stimulated with the target stimulation intensity. The central control unit 201 uses the amplitude as the current amplitude of the initial low-frequency sinusoidal stimulation current. It should be noted that in actual use, the stimulation intensity and the low-frequency sinusoidal stimulation current may not change in proportion. This application only takes the example of the stimulation intensity and the low-frequency sinusoidal stimulation current changing in proportion as an example.

[0065] Then, the central control unit 201 uses the stimulation frequency as the current frequency of the initial low-frequency sinusoidal stimulation current. It should be noted that the frequency of the magnetic field generated by the magnetic field coil is the same as the frequency of the low-frequency sinusoidal stimulation current flowing through the magnetic field coil. Therefore, in order to generate a low-frequency sinusoidal magnetic field, the stimulation frequency should be less than the fourth threshold. The fourth threshold can be pre-set according to the need for low-frequency sinusoidal magnetic nerve regulation of the subject.

[0066] Thus, based on the current amplitude and current frequency, the current generating circuit 202 can generate an initial low-frequency sinusoidal stimulation current of the total stimulation duration, and the total stimulation duration is the duration of the initial low-frequency sinusoidal stimulation current. Then, the central control unit 201 can control the on-off of the current generating circuit 202 based on the single stimulation duration and the interval time, and turn off the current generating circuit 202 during each interval time, so that the initial low-frequency sinusoidal stimulation current includes multiple stimulation cycles, and each stimulation cycle includes the initial low-frequency sinusoidal stimulation current of the single stimulation duration and the interval time.

[0067] For example, the current waveform of the initial low-frequency sinusoidal stimulation current is as follows: Figure 5 As shown in . Wherein, T is the total stimulation duration of the initial low-frequency sinusoidal stimulation current. The initial low-frequency sinusoidal stimulation current includes multiple stimulation cycles, such as Figure 5 As shown, the duration of each stimulation cycle is (t1+t2), t1 represents the duration of a single stimulation, that is, the duration of the initial low-frequency sinusoidal stimulation current of each stimulation cycle. t2 represents the interval time, that is, the interval time between the initial low-frequency sinusoidal stimulation currents of any two stimulation cycles. It should be noted that the present application Figure 5 The waveform of the initial low-frequency sinusoidal stimulation current of each stimulation cycle is only taken as an example to be explained as a complete sine wave. The waveform of the initial low-frequency sinusoidal stimulation current of each stimulation cycle can be any number of continuous phase waveforms in the sine wave, and this application does not limit this.

[0068] Therefore, the central control unit 201 can generate an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity through the current generating circuit 202 based on the target stimulation intensity and stimulation parameters, and send the initial low-frequency sinusoidal stimulation current to the magnetic field coil 203, so that the magnetic field coil 203 generates a low-frequency sinusoidal magnetic field, thereby performing low-frequency sinusoidal magnetic nerve regulation on the target area, thereby improving the accuracy of low-frequency sinusoidal magnetic nerve regulation.

[0069] In one embodiment of the present application, Figure 6 As shown, the low-frequency sinusoidal magnetic nerve regulation device 200 also includes a current sensor 206. The current sensor 206 is arranged on the connection path between the converter 305 and the magnetic field coil 203, and is connected to the fourth end of the central control unit, and is used to detect the first current parameter of the generated current of the current generating circuit 202. The generated current is the current actually generated by the current generating circuit, and the first current parameter includes the amplitude, frequency and phase of the generated current.

[0070] It should be noted that, since electromagnetic interference may exist in the current generating circuit 202 when generating the initial low-frequency sinusoidal stimulation current, the amplitude and frequency of the actual generated current may be different from the amplitude and frequency of the initial low-frequency sinusoidal stimulation current, and there may be a phase shift between the generated current and the initial low-frequency sinusoidal stimulation current. For this reason, the current sensor 206 needs to detect the generated current of the current generating circuit 202 to modulate the generated current into the initial low-frequency sinusoidal stimulation current.

[0071] Exemplarily, the central control unit 201 detects a first current parameter of the generated current of the current generating circuit 202 through the current sensor 206; if the first current parameter is different from the second current parameter of the initial low-frequency sinusoidal stimulation current, the central control unit 201 determines the modulation parameter based on the first current parameter and the second current parameter; the central control unit 201 modulates the generated current through the current generating circuit 202 based on the modulation parameter, so that the generated current of the current generating circuit 202 is the initial low-frequency sinusoidal stimulation current.

[0072] Specifically, the central control unit 201 compares the first current parameter of the generated current detected by the current sensor 206 with the second current parameter of the initial low-frequency sinusoidal stimulation current. The second current parameter includes the amplitude, frequency and phase of the initial low-frequency sinusoidal stimulation current. The central control unit 201 may compare the amplitude of the generated current with the amplitude of the initial low-frequency sinusoidal stimulation current, compare the frequency of the generated current with the frequency of the initial low-frequency sinusoidal stimulation current, and compare the phase of the generated current with the phase of the initial low-frequency sinusoidal stimulation current. When the first current parameter is different from the second current parameter, the central control unit 201 may determine the modulation parameter based on the first current parameter and the second current parameter, and the modulation parameter is the parameter required for the current generating circuit 202 to modulate the generated current from the first current parameter to the second current parameter. For example, when the amplitude of the generated current is less than the amplitude of the initial low-frequency sinusoidal stimulation current, the central control unit 201 determines the modulation parameter corresponding to the increase amount of the amplitude of the generated current based on the difference between the amplitude of the initial low-frequency sinusoidal stimulation current and the amplitude of the generated current.

[0073] Finally, based on the modulation parameter, the current modulation circuit 304 in the current generation circuit 202 modulates the generated current to modulate the generated current into an initial low-frequency sinusoidal stimulation current.

[0074] It can be seen that the central control unit 201 detects the first current parameter of the generated current of the current generating circuit 202 through the current sensor 206, and compares the first current parameter with the second current parameter of the initial low-frequency sinusoidal stimulation current. When the first current parameter is different from the second current parameter, the modulation parameter can be determined. The current generating circuit 202 can modulate the generated current into the initial low-frequency sinusoidal stimulation current based on the modulation parameter, so that the current generating circuit 202 sends an accurate initial low-frequency sinusoidal stimulation current to the magnetic field coil 203, thereby improving the accuracy of magnetic nerve regulation.

[0075] Alternatively, if Figure 6 As shown, the low-frequency sinusoidal magnetic nerve regulation device 200 also includes a display 207. The input end of the display 207 is connected to the fifth end of the central control unit 201. The central control unit 201 can also obtain the amplitude of the generated current detected by the current sensor; if the amplitude of the generated current is greater than the second threshold, the central control unit 201 interrupts the generated current output by the current generating circuit 202; the central control unit 201 displays the warning information corresponding to the generated current through the display 207.

[0076] It should be noted that when the amplitude of the current generated by the current generating circuit 202 exceeds the second threshold, the generated current at this time has exceeded the coil current threshold of the magnetic field coil, which is likely to cause damage to the magnetic field coil 203. In addition, the magnetic field generated by the generated current at this time, the induced electric field intensity generated in the target area has exceeded the maximum stimulation intensity that the brain neurons can withstand.

[0077] In order to ensure the safety of the low-frequency sinusoidal magnetic nerve regulation device 200, the central control unit 201 needs to obtain the amplitude of the generated current detected by the current sensor in real time. If the amplitude of the generated current is greater than the second threshold, the generated current output by the interruption current generating circuit 202 is interrupted to interrupt the current flowing into the magnetic field coil, so that the magnetic field coil cannot generate a magnetic field.

[0078] Furthermore, the central control unit 201 displays the warning information corresponding to the generated current through the display 207 to prompt the user that the amplitude of the generated current exceeds the second threshold. The warning information includes the amplitude of the generated current and the second threshold.

[0079] Thus, by real-time detection of the generated current of the current generating circuit 202, when the amplitude of the generated current is greater than the second threshold, the generated current of the current generating circuit 202 is interrupted, and the warning information of the generated current is displayed through the display 207, so that the amplitude of the generated current can be prevented from exceeding the coil current threshold of the magnetic field coil 203, thereby improving the safety of the low-frequency sinusoidal magnetic nerve regulation device 200. At the same time, it can also prevent the stimulation intensity of the target area from exceeding the maximum stimulation intensity that the brain neurons can withstand, thereby improving the safety of the use of the low-frequency sinusoidal magnetic nerve regulation device 200. The user can also obtain warning information from the display 207 and adjust the operation of the low-frequency sinusoidal magnetic nerve regulation device 200, further improving the safety of the use of the low-frequency sinusoidal magnetic nerve regulation device 200.

[0080] Furthermore, the magnetic field coil 203 generates a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current.

[0081] It should be noted that after the initial low-frequency sinusoidal stimulation current flows through the magnetic field coil 203, since the initial low-frequency sinusoidal stimulation current is an alternating current, a magnetic field is generated on the magnetic field coil 203. The frequency of the magnetic field is the same as the frequency of the initial low-frequency sinusoidal stimulation current, and the magnetic field strength at any point on the magnetic field changes in a sinusoidal wave, so the magnetic field generated on the magnetic field coil 203 is a low-frequency sinusoidal magnetic field. The waveform of the magnetic field strength at any point on the low-frequency sinusoidal magnetic field is similar to the waveform of the initial low-frequency sinusoidal stimulation current. When the initial low-frequency sinusoidal stimulation current is in the interval time, the low-frequency sinusoidal magnetic field will not be generated on the magnetic field coil 203.

[0082] Then, the magnetic field intensity sensor 204 detects the initial magnetic field intensity of the low-frequency sinusoidal magnetic field in the target area.

[0083] In the embodiment of the present application, the magnetic field intensity sensor 204 is placed on the scalp of the subject at the target area, and is used to detect the magnetic field intensity generated by the low-frequency sinusoidal magnetic field in the target area of ​​the subject.

[0084] It should be noted that since the low-frequency sinusoidal magnetic field is a changing magnetic field, the waveform of the magnetic field strength at any point on the low-frequency sinusoidal magnetic field is a sine wave. Therefore, the magnetic field strength of the target area of ​​the subject is a magnetic field strength that changes sinusoidally. The magnetic field strength sensor 204 detects the effective value of the magnetic field strength of the target area of ​​the subject. For example, the effective value may be the root mean square of the magnetic field strength. The magnetic field strength of the target area of ​​the subject may be expressed by formula (1):

[0085] Formula (1)

[0086] in, Indicates the effective value of the magnetic field strength in the target area, [ ] RMS represents the root mean square, represents the amplitude of the magnetic field strength in the target area, f represents the frequency of the low-frequency sinusoidal magnetic field, and t represents each moment in the duration of the low-frequency sinusoidal magnetic field. It can be understood that the function expression in [ ] in formula (1) is the function expression of the magnetic field strength in the target area. The magnetic field strength sensor 204 can obtain the effective value of the magnetic field strength in the target area, that is, the initial magnetic field strength, by acquiring the root mean square of the magnetic field strength in the target area.

[0087] Furthermore, the central control unit 201 determines the induced electric field strength generated by the initial magnetic field strength in the target area.

[0088] It should be noted that since the magnetic field strength at any point on the low-frequency sinusoidal magnetic field is a changing magnetic field strength, the changing magnetic field strength will generate an induced electric field, and the changing trend of the induced electric field strength at any point is similar to the changing trend of the magnetic field strength at that point. Therefore, the waveform of the induced electric field strength generated by the low-frequency sinusoidal magnetic field in the target area is a sine wave, and the frequency of the waveform is the same as that of the low-frequency sinusoidal magnetic field.

[0089] To this end, the induced electric field strength generated by the initial magnetic field strength determined by the central control unit 201 in the target area is the effective value of the induced electric field strength in the target area, and the effective value can be, for example, the root mean square of the induced electric field strength in the target area. The induced electric field strength in the target area is the derivative of the magnetic field strength in the target area with respect to time. After the root mean square of the induced electric field strength in the target area is calculated, the induced electric field strength can be expressed by formula (2):

[0090] Formula (2)

[0091] Wherein, E represents the effective value of the induced electric field strength of the target area. It can be seen from formula (2) that after determining the initial magnetic field strength, the central control unit 201 can determine the induced electric field strength of the target area based on the initial magnetic field strength.

[0092] In another embodiment of the present application, when determining the induced electric field strength generated by the initial magnetic field strength in the target area, the central control unit 201 obtains the magnetic field distribution function of the magnetic field coil 203; the central control unit 201 determines the induced electric field strength of the initial magnetic field strength in the target area based on the initial magnetic field strength and the magnetic field distribution function.

[0093] The magnetic field distribution function is used to represent the corresponding relationship function between the magnetic field intensity at any point on the low-frequency sinusoidal magnetic field generated by the magnetic field coil 203 and the induced electric field intensity at that point. The magnetic field distribution function can be preset according to actual test results. Optionally, the corresponding relationship function of the target area in the magnetic field distribution function can be the function shown in formula (2).

[0094] Thus, the central control unit 201 can determine the induced electric field strength of the initial magnetic field strength in the target area by acquiring the magnetic field distribution function of the magnetic field coil 203, based on the magnetic field distribution function and the initial magnetic field strength. Based on this, the determined induced electric field strength is the actual stimulation strength of the target area of ​​the subject, and by comparing the induced electric field strength with the target stimulation strength, it can be determined whether there is a deviation between the induced electric field strength and the target stimulation strength, thereby determining whether to adjust the induced electric field strength so that the induced electric field strength is equal to the target stimulation strength, thereby improving the accuracy of magnetic nerve regulation of the subject.

[0095] If the induced electric field strength is different from the target stimulation strength, the central control unit 201 determines the target low-frequency sinusoidal stimulation current of the magnetic field coil 203 based on the target stimulation strength.

[0096] It should be noted that since the target stimulation intensity is determined by the stimulation intensity ratio and the stimulation intensity threshold, and the stimulation intensity threshold is determined by stimulating the occipital lobe of the subject's back brain, when the low-frequency sinusoidal magnetic nerve regulation device 200 is actually used, the target area for magnetic nerve regulation of the subject can be any area. Therefore, there may be a deviation between the initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity sent by the current generating circuit 202 to the magnetic field coil 203 and the target low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity.

[0097] To this end, the central control unit 201 compares the induced electric field strength with the target stimulation strength. When the induced electric field strength is different from the target stimulation strength, the target low-frequency sinusoidal stimulation current of the magnetic field coil 203 is determined based on the target stimulation strength.

[0098] Exemplarily, when determining the target low-frequency sinusoidal stimulation current of the magnetic field coil 203 based on the target stimulation intensity, the central control unit 201 obtains the magnetic field distribution function of the magnetic field coil 203; the central control unit 201 determines the target magnetic field intensity generated by the magnetic field coil 203 in the target area based on the target stimulation intensity and the magnetic field distribution function; the central control unit 201 determines the target low-frequency sinusoidal stimulation current based on the target magnetic field intensity.

[0099] In the embodiment of the present application, the induced electric field intensity generated by the target magnetic field intensity in the target area is the target stimulation intensity. Specifically, the central control unit 201 can determine the corresponding relationship function between the magnetic field intensity and the induced electric field intensity at any point on the low-frequency sinusoidal magnetic field generated by the magnetic field coil 203 by acquiring the magnetic field distribution function of the magnetic field coil 203. Among them, the magnetic field distribution function is the same as the magnetic field distribution function of any of the above embodiments. The target stimulation intensity is the target induced electric field intensity in the target area of ​​the subject. Therefore, after acquiring the magnetic field distribution function, the target magnetic field intensity generated by the magnetic field coil 203 in the target area can be determined based on the target stimulation intensity and the magnetic field distribution function.

[0100] Furthermore, based on the target magnetic field strength, the central control unit 201 obtains the target low-frequency sinusoidal stimulation current corresponding to the magnetic field coil 203 when the target magnetic field strength is generated in the target area.

[0101] It can be seen that in the embodiment of the present application, the central control unit 201 can obtain the magnetic field distribution function of the magnetic field coil 203, and based on the magnetic field distribution function and the target stimulation intensity, can determine the target magnetic field intensity of the low-frequency sinusoidal magnetic field generated by the magnetic field coil 203 in the target area. Finally, based on the target magnetic field intensity, the central control unit 201 can determine the target low-frequency sinusoidal stimulation current. Thus, by determining the target low-frequency sinusoidal stimulation current, the central control unit 201 can adjust the initial low-frequency sinusoidal stimulation current to the target low-frequency sinusoidal stimulation current through the current generating circuit 202, so that the induced electric field intensity of the low-frequency sinusoidal magnetic field generated by the magnetic field coil 203 in the target area is the target stimulation intensity, thereby improving the accuracy of magnetic nerve regulation of the subject.

[0102] In the embodiment of the present application, after determining the target low-frequency sinusoidal stimulation current, the central control unit 201 sends the target low-frequency sinusoidal stimulation current to the magnetic field coil 203 through the current generating circuit 202, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil 203 in the target area is the target stimulation intensity.

[0103] The method by which the current generating circuit 202 sends the target low-frequency sinusoidal stimulation current to the magnetic field coil 203 is similar to the method by which the current generating circuit 202 sends the initial low-frequency sinusoidal stimulation current to the magnetic field coil 203, and will not be described in detail here. The target low-frequency sinusoidal stimulation current generates a low-frequency sinusoidal magnetic field after flowing through the magnetic field coil 203, and the magnetic field intensity of the generated low-frequency sinusoidal magnetic field in the target area is the target magnetic field intensity, and the induced electric field intensity in the target area is the target stimulation intensity.

[0104] In one embodiment of the present application, Figure 7As shown, the low-frequency sinusoidal magnetic nerve regulation device also includes a cooling system 600, and the cooling system 600 includes: a temperature sensor 601, a cooling control unit 602 and a cooling device 603. Optionally, the cooling device 603 may include: a high-pressure water pump 604, an evaporator water tank assembly 605, a condenser fan heat dissipation assembly 606, and a refrigeration compressor 607.

[0105] Among them, the first end of the temperature sensor 601 is connected to the third end of the magnetic field coil 203, and the second end of the temperature sensor 601 is connected to the first end of the cooling control unit 602. The second end of the cooling control unit 602 is connected to the first end of the high-pressure water pump 604, the third end of the cooling control unit 602 is connected to the first end of the condenser fan heat dissipation assembly 606, and the fourth end of the cooling control unit 602 is connected to the first end of the refrigeration compressor 607. The second end of the high-pressure water pump 604 is connected to the fourth end of the magnetic field coil 203, and the third end of the high-pressure water pump 604 is connected to the first end of the evaporator water tank assembly 605. The second end of the evaporator water tank assembly 605 is connected to the second end of the condenser fan heat dissipation assembly 606, and the third end of the evaporator water tank assembly 605 is connected to the second end of the refrigeration compressor 607. The third end of the condenser fan heat dissipation assembly 606 is connected to the third end of the refrigeration compressor 607.

[0106] Exemplarily, the temperature sensor 601 detects the temperature of the magnetic field coil 203. If the temperature is greater than the third threshold, the cooling control unit 602 cools the magnetic field coil 203 through the cooling device 603.

[0107] It should be noted that when the current flows through the magnetic field coil 203, not all of the electrical energy is converted into magnetic field energy, and some of the electrical energy is converted into heat energy, causing the magnetic field coil 203 to continuously heat up. In order to prevent the temperature of the magnetic field coil 203 from rising and causing damage to the magnetic field coil 203, and to avoid scalding the subject's brain, the temperature of the magnetic field coil 203 needs to be detected and adjusted in real time.

[0108] Specifically, the temperature sensor 601 can detect the temperature of the magnetic field coil 203 in real time. When the temperature of the magnetic field coil 203 is greater than the third threshold, in order to prevent the temperature of the magnetic field coil 203 from continuing to rise and reaching the maximum temperature that the subject's brain can withstand, the cooling control unit 602 will send a control signal to the cooling device 603. After receiving the control signal, the cooling device 603 cools the magnetic field coil 203 with a preset power. Optionally, the preset power can be the maximum power of the cooling device 603. When the temperature of the magnetic field coil 203 is greater than the third threshold, the high-pressure water pump 604, the evaporator water tank assembly 605, the condenser fan heat dissipation assembly 606, and the refrigeration compressor 607 all work at maximum power to cool the magnetic field coil 203.

[0109] Among them, the refrigeration compressor 607 is used to provide power for the evaporator water tank assembly 605 and the condenser fan heat dissipation assembly 606, the condenser fan heat dissipation assembly 606 is used to push the coolant in the evaporator water tank assembly 605 to the high-pressure water pump, and the high-pressure water pump is used to pump the coolant into the magnetic field coil 203 to cool the magnetic field coil 203.

[0110] It can be seen that in the embodiment of the present application, the temperature sensor 601 detects the temperature of the magnetic field coil 203 in real time. When the temperature of the magnetic field coil 203 is greater than the third threshold, the cooling control unit 602 can cool the magnetic field coil 203 through the cooling device 603, so that the temperature of the magnetic field coil 203 does not reach the maximum temperature that the subject's brain can withstand, and damage to the magnetic field coil 203 can be avoided, thereby improving the safety of use of the low-frequency sinusoidal magnetic nerve regulation device.

[0111] Optionally, a temperature sensor and a cooling fan may also be provided on the central control unit 201 to prevent the central control unit 201 from having a reduced processing efficiency due to an increase in temperature, thereby ensuring the real-time performance of magnetic neural regulation.

[0112] In summary, in the embodiment of the present application, when the target area of ​​the subject is subjected to low-frequency sinusoidal magnetic nerve regulation, the central control unit obtains input parameters, including the stimulation intensity ratio and the stimulation parameters. Then, the central control unit can determine the target stimulation intensity based on the stimulation intensity ratio and the pre-determined stimulation intensity threshold. Further, based on the target stimulation intensity and the stimulation parameters, the central control unit can send an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil through the current generating circuit. Then, the magnetic field coil can generate a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current, and detect the initial magnetic field intensity of the low-frequency sinusoidal magnetic field in the target area through the magnetic field intensity sensor. The central control unit can determine the induced electric field intensity generated by the initial magnetic field intensity in the target area of ​​the subject. If the induced electric field intensity is different from the target stimulation intensity, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined based on the target stimulation intensity. Finally, the target low-frequency sinusoidal stimulation current is sent to the magnetic field coil through the current generating circuit, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area of ​​the subject is the target stimulation intensity. Thus, by detecting the initial magnetic field strength of the low-frequency sinusoidal magnetic field generated by the magnetic field coil, the induced electric field strength of the initial magnetic field strength in the target area is determined, so that when the induced electric field strength is different from the target stimulation strength, the initial low-frequency sinusoidal stimulation current of the magnetic field coil can be adjusted to the target low-frequency sinusoidal stimulation current. Based on this, when the corresponding relationship between the target stimulation intensity and the initial low-frequency sinusoidal stimulation current is determined in advance, the low-frequency sinusoidal magnetic nerve regulation device of the present application can dynamically adjust the low-frequency sinusoidal stimulation current of the magnetic field coil based on the induced electric field strength and the target stimulation intensity generated in the target area, so that the induced electric field strength generated in the target area is the target stimulation intensity, thereby improving the accuracy of low-frequency sinusoidal magnetic nerve regulation on the subject.

[0113] See also Figure 8 , Figure 8 A schematic flow chart of a low-frequency sinusoidal magnetic nerve regulation method provided in an embodiment of the present application. The method is applied to the above-mentioned low-frequency sinusoidal magnetic nerve regulation device 200, and the method includes but is not limited to the following steps:

[0114] S801: When performing low-frequency sinusoidal magnetic nerve regulation on the target area of ​​the subject, input parameters are obtained, and the input parameters include: stimulation intensity ratio and stimulation parameters.

[0115] S802: Determine a target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold.

[0116] S803: Based on the target stimulation intensity and stimulation parameters, an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity is sent to the magnetic field coil through the current generating circuit.

[0117] S804: Generate a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current.

[0118] S805: Detect the initial magnetic field strength of the low-frequency sinusoidal magnetic field in the target area.

[0119] S806: Determine the induced electric field strength generated by the initial magnetic field strength in the target area.

[0120] S807: If the evoked electric field intensity is different from the target stimulation intensity, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined based on the target stimulation intensity.

[0121] S808: Sending a target low-frequency sinusoidal stimulation current to the magnetic field coil through the current generating circuit, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area is the target stimulation intensity.

[0122] The specific implementation process of steps S801 to S808 may refer to the specific functions of the central control unit, current generating circuit, magnetic field coil and magnetic field intensity sensor mentioned above, which will not be repeated here.

[0123] See also Fig. 9 , Fig. 9 This is a schematic diagram of the structure of an electronic device provided in an embodiment of the present application. Fig. 9 As shown, the electronic device 900 includes a transceiver 901, a processor 902 and a memory 903. They are connected via a bus 904. The memory 903 is used to store computer programs and data, and can transmit the data stored in the memory 903 to the processor 902. The electronic device 900 can be the above-mentioned low-frequency sinusoidal magnetic nerve regulation device 200. The processor 902 is used to read the computer program in the memory 903 to execute the various steps of the low-frequency sinusoidal magnetic nerve regulation method of the embodiment of the present application.

[0124] The processor 902 can adopt a general-purpose central processing unit (CPU), a microprocessor, an application-specific integrated circuit (ASIC), a graphics processing unit (GPU) or one or more integrated circuits to execute relevant programs to realize the functions required to be performed by the units in the low-frequency sinusoidal magnetic nerve regulation device, or to execute the low-frequency sinusoidal magnetic nerve regulation method of the method embodiment of the present application.

[0125] The processor 902 may also be an integrated circuit chip with signal processing capabilities. In the implementation process, each step in the low-frequency sinusoidal magnetic nerve regulation method of the present application may be completed by an integrated logic circuit of hardware or software instructions in the processor 902. The above-mentioned processor 902 may also be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. The methods, steps and logic block diagrams disclosed in the embodiments of the present application may be implemented or executed. The general-purpose processor may be a microprocessor or the processor may also be any conventional processor, etc. The steps of the method disclosed in the embodiments of the present application may be directly embodied as being executed by a hardware decoding processor, or may be executed by a combination of hardware and software modules in a decoding processor. The software module may be located in a mature storage medium in the art such as a random access memory, a flash memory, a read-only memory, a programmable read-only memory or an electrically erasable programmable memory, a register, etc. The storage medium is located in the memory 903, and the processor 902 reads the information in the memory 903, and combines its hardware to complete the functions required to be performed by the units included in the low-frequency sinusoidal magnetic nerve regulation device of the embodiment of the present application, or executes the various steps in the low-frequency sinusoidal magnetic nerve regulation method of the method embodiment of the present application.

[0126] The transceiver 901 is used to implement communication between the electronic device 900 and other devices or a communication network. The bus 904 may include a path for transmitting information between various components of the electronic device 900 (eg, the transceiver 901, the processor 902, and the memory 903).

[0127] It should be noted that although Fig. 9 The electronic device 900 shown only shows a transceiver, a memory, and a processor, but in the specific implementation process, those skilled in the art should understand that the electronic device 900 also includes other devices necessary for normal operation. At the same time, according to specific needs, those skilled in the art should understand that the electronic device 900 may also include hardware devices for implementing other additional functions. In addition, those skilled in the art should understand that the electronic device 900 may also only include the devices necessary for implementing the embodiments of the present application, and does not necessarily include Fig. 9 All devices shown in .

[0128] Those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working processes of the above-described equipment, devices and units can refer to the corresponding processes in the aforementioned method embodiments and will not be repeated here.

[0129] An embodiment of the present application also provides a computer-readable storage medium, which stores a computer program, and the computer program is executed by a processor to implement part or all of the steps of any low-frequency sinusoidal magnetic nerve regulation method recorded in the above method embodiments.

[0130] An embodiment of the present application also provides a computer program product, which includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to execute part or all of the steps of any low-frequency sinusoidal magnetic nerve regulation method recorded in the above method embodiments.

[0131] It should be noted that, for the aforementioned method embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the present application is not limited by the described order of actions, because according to the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all optional embodiments, and the actions and modules involved are not necessarily required by the present application.

[0132] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0133] In the several embodiments provided in the present application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only schematic, such as the division of the units, which is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, and the indirect coupling or communication connection of the device or unit can be electrical or other forms.

[0134] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0135] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above integrated unit may be implemented in the form of hardware or in the form of a software program module.

[0136] If the integrated unit is implemented in the form of a software program module and sold or used as an independent product, it can be stored in a computer-readable memory. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product. The computer software product is stored in a memory, including a number of instructions to enable a computer device (which can be a personal computer, server or network device, etc.) to execute all or part of the steps of the method described in each embodiment of the present application. The aforementioned memory includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, disk or optical disk and other media that can store program codes.

[0137] Those skilled in the art will appreciate that all or part of the steps in the various methods of the above embodiments may be completed by instructing related hardware through a program, and the program may be stored in a computer-readable memory, which may include a flash drive, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, etc.

[0138] The embodiments of the present application are introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and core idea of ​​the present application. At the same time, for general technical personnel in this field, according to the idea of ​​the present application, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A low-frequency sinusoidal magnetic nerve control device, characterized in that: The low-frequency sinusoidal magnetic nerve control device comprises: a central control unit, a current generating circuit, a magnetic field coil and a magnetic field intensity sensor; When low-frequency sinusoidal magnetic nerve regulation is performed on the target area of ​​the subject, the central control unit is used to obtain input parameters, and the input parameters include: stimulation intensity ratio and stimulation parameters; Determining a target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold; Based on the target stimulation intensity and the stimulation parameters, sending an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil through the current generating circuit; The magnetic field coil is used to generate a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current; The magnetic field intensity sensor is used to detect the initial magnetic field intensity of the low-frequency sinusoidal magnetic field in the target area; The central control unit is used to determine the induced electric field strength generated by the initial magnetic field strength in the target area; specifically, to: obtain the magnetic field distribution function of the magnetic field coil; and determine the induced electric field strength of the initial magnetic field strength in the target area based on the initial magnetic field strength and the magnetic field distribution function; If the induced electric field strength is different from the target stimulation strength, then based on the target stimulation strength, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined; specifically used for: determining the target magnetic field strength generated by the magnetic field coil in the target area based on the target stimulation strength and the magnetic field distribution function, wherein the induced electric field strength generated by the target magnetic field strength in the target area is the target stimulation strength; determining the target low-frequency sinusoidal stimulation current based on the target magnetic field strength; The target low-frequency sinusoidal stimulation current is sent to the magnetic field coil by the current generating circuit, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area is the target stimulation intensity.

2. The low-frequency sinusoidal magnetic nerve control device according to claim 1, characterized in that: The input parameters also include: initial stimulation intensity; The central control unit is also used for: Based on the initial stimulation intensity, the current generating circuit periodically sends an initial low-frequency sinusoidal stimulation current corresponding to the initial stimulation intensity to the magnetic field coil, so that the low-frequency sinusoidal magnetic field generated by the magnetic field coil generates multiple stimulations on the occipital lobe of the subject's back head, wherein the initial low-frequency sinusoidal stimulation current of each cycle includes: a low-frequency sinusoidal stimulation current of a preset duration and an interval time; Obtaining the number of responses of the subject to the multiple stimuli; If the number of responses to the multiple stimuli is less than a first threshold, the starting stimulation intensity is increased by a preset intensity to obtain a new starting stimulation intensity; based on the new starting stimulation intensity, the number of responses of the subject to the new multiple stimuli is determined until the number of responses corresponding to the new starting stimulation intensity is greater than or equal to the first threshold; and the new starting stimulation intensity is used as the stimulation intensity threshold.

3. The low-frequency sinusoidal magnetic nerve control device according to claim 1, characterized in that: The stimulation parameters include: stimulation frequency, total stimulation duration, single stimulation duration and interval time; In terms of sending an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity to the magnetic field coil through the current generating circuit based on the target stimulation intensity and the stimulation parameters, the central control unit is specifically configured to: Acquiring the amplitude of the low-frequency sinusoidal stimulation current when stimulating the occipital lobe of the subject at the target stimulation intensity; using the amplitude as the current amplitude of the initial low-frequency sinusoidal stimulation current; Using the stimulation frequency as the current frequency of the initial low-frequency sinusoidal stimulation current; Based on the current amplitude, the current frequency, the single stimulation duration and the interval time, the initial low-frequency sinusoidal stimulation current of the total stimulation duration is continuously sent to the magnetic field coil through the current generating circuit, wherein the initial low-frequency sinusoidal stimulation current includes multiple stimulation cycles, and each stimulation cycle includes the initial low-frequency sinusoidal stimulation current of the single stimulation duration and the interval time.

4. The low-frequency sinusoidal magnetic nerve control device according to claim 3, characterized in that: The low-frequency sinusoidal magnetic nerve control device also includes a current sensor; The central control unit is also used for: Detecting a first current parameter of a generated current of the current generating circuit by the current sensor; If the first current parameter is different from the second current parameter of the initial low-frequency sinusoidal stimulation current, determining a modulation parameter based on the first current parameter and the second current parameter; Based on the modulation parameters, the generated current is modulated by the current generating circuit so that the generated current of the current generating circuit is the initial low-frequency sinusoidal stimulation current.

5. The low-frequency sinusoidal magnetic nerve control device according to claim 4, characterized in that: The low-frequency sinusoidal magnetic nerve regulation device also includes a display; The central control unit is also used for: acquiring the amplitude of the generated current detected by the current sensor; If the amplitude of the generated current is greater than a second threshold, interrupting the generated current output by the current generating circuit; The display displays warning information corresponding to the generated current.

6. The low-frequency sinusoidal magnetic nerve control device according to any one of claims 1 to 5, characterized in that: The low-frequency sinusoidal magnetic nerve regulation device also includes a cooling system, which includes: a temperature sensor, a cooling control unit and a cooling device; The temperature sensor is used to detect the temperature of the magnetic field coil; The cooling control unit is used to cool the magnetic field coil through the cooling device if the temperature is greater than a third threshold.

7. An electronic device, characterized in that: include: A processor and a memory, wherein the processor is connected to the memory, the memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory, so that the electronic device performs the following steps: When performing low-frequency sinusoidal magnetic nerve regulation on the target area of ​​the subject, input parameters are obtained, and the input parameters include: stimulation intensity ratio and stimulation parameters; Determining a target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold; Based on the target stimulation intensity and the stimulation parameters, an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity is sent to the magnetic field coil through a current generating circuit; generating a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current; Detecting the initial magnetic field strength of the low-frequency sinusoidal magnetic field in the target area; Determining the induced electric field strength generated by the initial magnetic field strength in the target area; comprising: acquiring the magnetic field distribution function of the magnetic field coil; determining the induced electric field strength of the initial magnetic field strength in the target area based on the initial magnetic field strength and the magnetic field distribution function; If the induced electric field strength is different from the target stimulation strength, then based on the target stimulation strength, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined; including: based on the target stimulation strength and the magnetic field distribution function, determining the target magnetic field strength generated by the magnetic field coil in the target area, wherein the induced electric field strength generated by the target magnetic field strength in the target area is the target stimulation strength; based on the target magnetic field strength, determining the target low-frequency sinusoidal stimulation current; The target low-frequency sinusoidal stimulation current is sent to the magnetic field coil by the current generating circuit, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area is the target stimulation intensity.

8. A computer-readable storage medium, characterized in that: The computer readable storage medium stores a computer program, and the computer program is executed by a processor to implement the following steps: When performing low-frequency sinusoidal magnetic nerve regulation on the target area of ​​the subject, input parameters are obtained, and the input parameters include: stimulation intensity ratio and stimulation parameters; Determining a target stimulation intensity based on the stimulation intensity ratio and the stimulation intensity threshold; Based on the target stimulation intensity and the stimulation parameters, an initial low-frequency sinusoidal stimulation current corresponding to the target stimulation intensity is sent to the magnetic field coil through a current generating circuit; generating a low-frequency sinusoidal magnetic field corresponding to the initial low-frequency sinusoidal stimulation current; Detecting the initial magnetic field strength of the low-frequency sinusoidal magnetic field in the target area; Determining the induced electric field strength generated by the initial magnetic field strength in the target area; comprising: acquiring the magnetic field distribution function of the magnetic field coil; determining the induced electric field strength of the initial magnetic field strength in the target area based on the initial magnetic field strength and the magnetic field distribution function; If the induced electric field strength is different from the target stimulation strength, then based on the target stimulation strength, the target low-frequency sinusoidal stimulation current of the magnetic field coil is determined; including: based on the target stimulation strength and the magnetic field distribution function, determining the target magnetic field strength generated by the magnetic field coil in the target area, wherein the induced electric field strength generated by the target magnetic field strength in the target area is the target stimulation strength; based on the target magnetic field strength, determining the target low-frequency sinusoidal stimulation current; The target low-frequency sinusoidal stimulation current is sent to the magnetic field coil by the current generating circuit, so that the induced electric field intensity generated by the low-frequency sinusoidal magnetic field generated by the magnetic field coil in the target area is the target stimulation intensity.

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