A dispersible oil suspension containing fenobucarb and flonicamid and preparation method thereof

Abstract

The present invention relates to the technical field of pesticide preparations, and in particular to a dispersible oil suspension containing fenbucarb and flonicamid and a preparation method thereof, comprising the following components in percentage by weight: 10-40% of fenbucarb, 5-15% of flonicamid, 1-7% of a synergist, 1-10% of a dispersant, 10-25% of an emulsifier, 1-5% of a suspending agent, and 100% of a solvent; the synergist is composed of Quick T, ramie oil and NF-100, and the mass ratio of Quick T, ramie oil and NF-100 is 1-3:1-3:1-3. The dispersible oil suspension prepared by the present invention has excellent preparation performance, and has excellent control effect on the pest green peach aphid.

Description

Technical Field

[0001] The present invention relates to the technical field of pesticide preparations, and in particular to a dispersible oil suspension containing fenobucarb and flonicamid and a preparation method thereof. Background Art

[0002] Fenbucarb belongs to the carbamate insecticide class, which mainly poisons and kills pests by inhibiting acetylcholinesterase. It has a strong contact killing effect, and has certain stomach poison, fumigation and egg killing effects. Flonamid belongs to a new type of pyridine amide insect growth regulator insecticide, which has good nerve inhibition and rapid antifeedant effects in addition to contact killing and stomach poison effects, and can be absorbed and transmitted by young plant tissues.

[0003] Patent document CN103053564A discloses a composite insecticide composition containing flonicamid and fosamil, wherein the insecticide composition contains flonicamid and fosamil as main active ingredients, and the weight ratio of flonicamid to fosamil is 0.1-80:0.5-80. The dosage form of the composition is emulsifiable concentrate, suspension concentrate, aqueous emulsion, wettable powder, microemulsion or water-dispersible granule. The patent document does not disclose the relevant dispersible oil suspension.

[0004] The 30% flonicamid·fenbucarb dispersible oil suspension registered by our company Guangdong Zhen Biotechnology Co., Ltd., registration number: PD20231143, is mixed with flonicamid·fenbucarb, and the dosage of the preparation is 3000-4000 times liquid, which can effectively control peach aphids. However, when used in the actual field, the field control effect needs to be further improved.

[0005] Dispersible oil suspensions are composed of one or more solid pesticide active ingredients that are poorly soluble or slightly soluble in non-aqueous media, and rely on surfactants and viscosity regulators to form highly dispersed and stable suspension liquid preparations. In view of the shortcomings of the prior art, the present invention develops a dispersible oil suspension containing flonicamid and famoxadone with excellent biological activity. Summary of the invention

[0006] The object of the present invention is to provide a dispersible oil suspension containing fenobucarb and flonicamid and a preparation method thereof, and the specific technical scheme is:

[0007] A dispersible oil suspension containing fenbucarb and flonicamid, comprising the following ingredients in percentage by weight: 10-40% fenbucarb, 5-15% flonicamid, 1-7% synergist, 1-10% dispersant, 10-25% emulsifier, 1-5% suspending agent, and 100% solvent;

[0008] The synergist consists of Kuai T, ramie oil and NF-100, and the mass ratio of Kuai T, ramie oil and NF-100 is 1-3:1-3:1-3.

[0009] The preferred dispersible oil suspension contains the following ingredients in percentage by weight: 20% of famoxadone, 10% of flonicamid, 1-7% of synergist, 1-10% of dispersant, 10-25% of emulsifier, 1-5% of organic bentonite, and 100% of solvent.

[0010] The dispersant consists of calcium dodecylbenzene sulfonate and calcium lignin sulfonate, and the mass ratio of calcium dodecylbenzene sulfonate to calcium lignin sulfonate is 1-3:1-3.

[0011] The emulsifier consists of Tween 80 and Ethylan NS-500LQ, and the mass ratio of Tween 80 to Ethylan NS-500LQ is 5-15:5-15.

[0012] The suspending agent is organic bentonite.

[0013] The solvent is methyl oleate.

[0014] Preferably, the dispersible oil suspension contains the following ingredients in percentage by weight: 20% of famoxadiazine, 10% of flonicamid, 1.5% of fast T, 1.5% of ramie oil, 1.5% of NF-100, 3% of calcium dodecylbenzene sulfonate, 2% of calcium lignin sulfonate, 8% of Tween 80, 10% of EthylanNS-500LQ, 2% of organic bentonite, and 100% of methyl oleate.

[0015] The dispersible oil suspension of the present invention is used for preventing and controlling pests, and preferably the pests are green peach aphids.

[0016] By adopting the above technical solution, the present invention has the following beneficial effects:

[0017] The dispersible oil suspension prepared by the present invention and containing fenbucarb and flonicamid has excellent formulation performance, good suspension performance and excellent water dispersibility, and no particles sink; the dispersible oil suspension prepared by the present invention through the selection of synergists and a specific synergist combination has excellent control effect on the pest peach aphid. DETAILED DESCRIPTION

[0018] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present invention.

[0019] The present invention is further explained below in conjunction with specific implementation modes.

[0020] Example 1: Preparation of dispersible oil suspension concentrates of famoxadifen and flonicamid and their index testing

[0021] Test materials: See Table 1. The above active ingredients and excipients were purchased from the market.

[0022] Main instruments and equipment: electronic balance, multifunctional dispersing sand mill, magnetic stirrer, high-speed shearing machine, high-performance liquid chromatograph, pH meter, laser particle size distribution analyzer;

[0023] Preparation process: Accurately weigh the required technical, auxiliary and dispersing medium, stir and disperse the active ingredients, emulsifier, synergist, suspending agent organic bentonite and solvent evenly with a magnetic stirrer, add the dispersant and shear evenly with a high-speed shearing machine, transfer the evenly sheared slurry into a sand mill for primary and secondary sand grinding in sequence, after sand grinding, take samples for testing of particle size, dispersion, emulsification and other indicators, filter and fill after passing the test.

[0024] Preparation index test

[0025] Determination of water dispersibility

[0026] Suspend 1.25g of the drug solution to be tested at 5cm above the 250ml stoppered measuring cylinder and drop it. Observe the corresponding water dispersing effect and divide it into three levels: Excellent: No particles sink, and the whole is separated in a cloud-like state. Good: It can be dispersed by stirring, and no particles sink. Poor: It is difficult to disperse or not dispersed by stirring, and particles sink.

[0027] Suspension rate determination: refer to GB / T14825-2006.

[0028] Moisture determination: Karl Fischer Coulometry.

[0029] Persistent foaming property determination: refer to GB / T28137-2011.

[0030] Storage stability test:

[0031] Thermal storage stability: Take 50 mL of the dispersible oil suspension sample to be tested and place it in a highly airtight sealed container. Place it in an oven at (54±2)℃ for 14 days. After taking it out, observe its appearance and fluidity, and determine its active ingredient content, suspension rate and other indicators.

[0032] Cold storage stability: Take 50mL of the dispersible oil suspension sample to be tested and place it in a highly airtight sealed container. Place it in a refrigerator at (0±2)℃ for 14 days, observe its appearance and fluidity, or return it to room temperature to flow to determine the corresponding active ingredient decomposition rate, suspension rate, oil separation rate and other indicators.

[0033] Table 1 30% Fenbucarb and Flonac dispersible oil suspension concentrates

[0034]

[0035] Results and Analysis:

[0036] The dispersible oil suspension prepared by the present invention has excellent suspension performance and excellent water dispersibility, no particles sink, and the whole is separated in a cloud-like state; it has low persistent foaming property, and the hot storage stability and cold storage stability are qualified.

[0037] Table 2 Quality indexes of 30% Fenbucarb and Flonac dispersible oil suspension

[0038]

[0039] Example 2: Field evaluation of the efficacy of dispersible oil suspensions against green peach aphids

[0040] Test site: The test site has sandy soil, peach tree row spacing is 4.0m×3.0m, the trees are 5 years old, the cultivation conditions are consistent, and the peach aphid occurrence is widespread and uniform.

[0041] Test drug:

[0042] Experimental design: There are 8 treatments in total, and spraying water is used as a control. There are 4 trees in each plot, repeated 4 times, and a total of 28 plots, and each plot is randomly arranged.

[0043] Application method: Use a backpack sprayer to spray evenly so that all the leaves are evenly covered with medicine on both sides. The actual water consumption per mu is 100L. No other pesticides were applied during the test.

[0044] Survey method: According to the "National Standard of the People's Republic of China Pesticide Field Efficacy Test Guidelines (I) Insecticide Control of Fruit Tree Aphids" (GB / T17980.9-2000), 2 plants were surveyed in each plot, and 5 damaged shoots were fixed in the east, south, west, north and center of each plant. The number of live aphids on the top 10 leaves of each shoot was surveyed. The base number of insects was surveyed before spraying, and the number of live aphids on each treatment sign was surveyed 7 and 14 days after spraying.

[0045] Control effect (%) = [1-(number of live aphids in the clean water control area before treatment × number of live aphids in the treated area after treatment) / (number of live aphids in the clean water control area after treatment × number of live aphids in the treated area before treatment)] × 100

[0046] Results and Analysis

[0047] Table 3 Effect of 30% fenbucarb and flonicamid dispersible oil suspension on green peach aphid

[0048] Field control effect

[0049]

[0050] As shown in Table 3, the dispersible oil suspension in the positive control (registration number PD20231143) had a field control effect of only 81.82% and 79.75% on green peach aphids at 7d and 14d after application at a dilution multiple of 2500 times. When one or two of the synergists Quick T, ramie oil or NF-100 were added to the dispersible oil suspension, the field control effect on green peach aphids was improved to a certain extent; however, the combination of the synergist Quick T, ramie oil and NF-100 significantly improved the control effect of the dispersible oil suspension on green peach aphids, which was significantly different from other treatments.

[0051] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it.

Claims

1. A dispersible oil suspension containing fenbucarb and flonicamid, characterized in that: The composition comprises the following ingredients in percentage by weight: 10-40% of famoxadicarb, 5-15% of flonicamid, 1-7% of synergist, 1-10% of dispersant, 10-25% of emulsifier, 1-5% of suspending agent, and 100% of solvent. The synergist is composed of Kuai T, ramie oil and NF-100, and the mass ratio of Kuai T, ramie oil and NF-100 is 1-3:1-3:1-3; The dispersant is composed of calcium dodecylbenzene sulfonate and calcium lignin sulfonate, and the mass ratio of calcium dodecylbenzene sulfonate to calcium lignin sulfonate is 1-3:1-3; The emulsifier is composed of Tween 80 and Ethylan NS-500LQ, and the mass ratio of Tween 80 to Ethylan NS-500LQ is 5-15:5-15; The suspending agent is organic bentonite; The solvent is methyl oleate.

2. The dispersible oil suspension according to claim 1, characterized in that: The invention comprises the following ingredients in percentage by weight: 20% of famoxadone, 10% of flonicamid, 1.5% of fast T, 1.5% of ramie oil, 1.5% of NF-100, 3% of calcium dodecylbenzene sulfonate, 2% of calcium lignin sulfonate, 8% of Tween 80, 10% of Ethylan NS-500LQ, 2% of organic bentonite, and 100% of methyl oleate.

3. Use of the dispersible oil suspension according to any one of claims 1 to 2 for controlling pests, characterized in that: The pest is green peach aphid.

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