Febuxostat raw material particle size detection device and method

Abstract

The present invention relates to the field of raw material particle size detection devices, specifically a Febuxostat raw material particle size detection device and method, including a detection tank body, the top of the detection tank body is fixedly connected with a screening motor, and the rotating end of the screening motor passes through the detection tank body and is fixedly connected with a support rod. This Febuxostat raw material particle size detection device is composed of a screening mechanism and an adjustment mechanism; when the screening cylinder swings inside the detection tank body to detect the Febuxostat raw material by a screening method, under the cooperation of the screening mechanism and the adjustment mechanism, the crushing cylinder and the exhaust plate are moved relative to or opposite to each other between the top and the bottom of the screening cylinder, and the agglomerated Febuxostat raw material is crushed, and at the same time, the large particles of the Febuxostat raw material are crushed by the crushing cylinder, so that the unqualified Febuxostat raw material is crushed into qualified products while ensuring the detection of the Febuxostat raw material, thereby improving the functionality of the detection equipment.

Description

Technical Field

[0001] The invention relates to the field of raw drug material particle size detection devices, and in particular to a Febuxostat raw material particle size detection device and method. Background Art

[0002] Febuxostat is a xanthine oxidase inhibitor suitable for the long-term treatment of hyperuricemia with gout symptoms. The particle size of Febuxostat API is one of the important factors in the development and control of solid dosage forms, which will have a significant impact on the quality indicators of the final product, such as bioavailability, solubility, uniformity, and stability.

[0003] Microscopy, screening, laser scattering and the like are usually used to detect the particle size of Febuxostat raw materials, among which screening is the most widely used.

[0004] Since the Febuxostat API is a powdery substance, it contains large particles or agglomerated drug particles. Some existing Febuxostat API particle size detection devices can only remove large particles during use, and it is difficult to effectively process large particles or agglomerated drug particles, and the functionality is poor. Summary of the invention

[0005] The purpose of the present invention is to provide a Febuxostat raw material particle size detection device and method to solve the problems raised in the above background technology: 1. It is difficult to effectively process the detected large particles or agglomerated drug particles during use of some existing Febuxostat raw material particle size detection devices. To achieve the above purpose, the present invention provides the following technical solutions: a Febuxostat raw material particle size detection device, comprising a detection tank body, the top of the detection tank body is fixedly connected to a screening motor, the rotating end of the screening motor passes through the detection tank body and is fixedly connected to a support rod, and the bottom of the support rod is fixedly connected to a support cylinder;

[0006] The upper part of the inner wall of the detection tank is fixedly connected with a rubber ring, the inner ring of the rubber ring is fixedly connected with a screening cylinder, the lower part of the support cylinder is rotatably connected to the inner bottom surface of the screening cylinder, and a screening mechanism is movably connected between the upper part of the screening cylinder and the inside of the support cylinder;

[0007] An adjusting mechanism matched with the screening mechanism is movably connected between the bottom of the screening cylinder and the inside of the supporting cylinder, and an adjusting ring matched with the adjusting mechanism is fixedly connected to the lower part of the inner wall of the detection tank;

[0008] Both sides of the detection tank body are symmetrically provided with slide grooves, the interior of the slide grooves is slidably connected with a slide rod, and the surface of the slide rod is fixedly connected to the side wall of the screening cylinder;

[0009] The screening mechanism comprises a cross-shaped bracket, the cross-shaped bracket is fixedly connected to the top of the screening cylinder, the inner ring of the upper part of the cross-shaped bracket is fixedly connected with a protrusion, and the upper part of the support rod is fixedly sleeved with a cam matched with the protrusion;

[0010] A movable groove is provided on the middle side wall of the support tube, a concave adjustment tube is slidably connected to the upper part of the inner wall of the support tube, a threaded groove matching the adjustment mechanism is provided on the inner wall of the concave adjustment tube, and a compression spring is fixedly connected between the top of the concave adjustment tube and the inner top surface of the support tube;

[0011] The side wall of the concave adjustment cylinder is fixedly connected with a movable block, one end of the movable block passes through the movable groove and is fixedly connected with a crushing cylinder, one side of the crushing cylinder overlaps with the side wall of the support cylinder, and the other side of the crushing cylinder overlaps with the inner wall of the screening cylinder;

[0012] The side wall of the crushing cylinder is provided with a material guiding chute, the middle part of the crushing cylinder is provided with a crushing groove matched with the material guiding chute vertically, the inner wall of the crushing groove is symmetrically rotatably connected with a rotating rod, the middle part of the rotating rod is fixedly sleeved with a crushing roller, the inner wall of the crushing cylinder is provided with a transmission groove matched with the end of the rotating rod, the end of the rotating rod extends to the inside of the transmission groove and is fixedly sleeved with a transmission gear, the inner wall of the transmission groove is vertically slidably connected with a transmission rack rod, and the lower part of the transmission rack rod is movably inserted into the inner bottom surface of the transmission groove.

[0013] Preferably, a sealed bearing is fixedly connected to the center of the bottom of the screening cylinder, and the outer ring of the lower part of the support cylinder is fixedly connected to the inner ring of the sealed bearing;

[0014] The bottom of the screening cylinder is fixedly connected with an annular microporous screening net, and the annular microporous screening net is set as a metal net.

[0015] Preferably, one side of the pulverizing cylinder is configured as an arc-shaped surface that matches the outer wall of the supporting cylinder, and the material guiding chute is arranged along the trajectory direction of the rotation of the pulverizing cylinder.

[0016] Preferably, a secondary sealed bearing is fixedly connected between the inner wall of the transmission groove and the inner wall of the crushing groove, and the outer ring of the rotating rod is fixedly connected to the inner ring of the secondary sealed bearing;

[0017] A guide groove is vertically opened on the inner wall of the transmission groove, a guide rod is vertically fixedly connected to the inside of the guide groove, a guide block is fixedly connected to the side wall of the transmission rack rod, the guide block is slidably connected to the surface corresponding to the guide rod, and the upper part of the guide rod is movably sleeved with a guide spring that cooperates with the guide block.

[0018] Preferably, the adjustment mechanism comprises a connecting ring, the connecting ring is fixedly connected to the bottom of the screening cylinder, the top of the connecting ring overlaps the bottom of the supporting cylinder, and the bottom of the connecting ring is fixedly connected with twelve wedge blocks at equal intervals along the circumference;

[0019] The inner bottom of the support cylinder is vertically slidably connected with an adjustment shaft, and the side wall of the upper part of the adjustment shaft is symmetrically provided with grooves, and the inside of the groove is rotatably connected with an adjustment gear that matches the screening mechanism;

[0020] The bottom of the adjusting shaft passes through the connecting ring and is fixedly connected with a pad, the top of the pad is fixedly connected with four ball head push rods at equal intervals along the circumference, and the top of the ball head push rod overlaps with the surface of the corresponding wedge block;

[0021] The side wall of the pad is fixedly connected to a synchronous bracket, one end of the synchronous bracket is fixedly connected to a piston cylinder, the top of the piston cylinder is fixedly connected to an exhaust plate that matches the screening cylinder, the interior of the piston cylinder is slidably connected to a piston rod that matches the adjusting ring, the bottom of the piston cylinder away from the piston rod is fixedly connected to an intake valve, the side of the piston cylinder close to the intake valve is symmetrically fixedly connected to an exhaust pipe, and the top of the exhaust pipe is fixedly connected to the bottom of the exhaust plate.

[0022] Preferably, a piston spring is fixedly connected between the end of the piston rod and the inner wall of the piston cylinder, and a one-way valve is fixedly connected between the end of the exhaust pipe and the surface of the piston cylinder.

[0023] Preferably, a vertical hole is provided at the bottom of the support tube, the adjustment shaft is movably inserted into the vertical hole, a rectangular block is symmetrically fixedly connected to the inner wall of the vertical hole, a rectangular groove is symmetrically provided on the surface of the adjustment shaft, and the rectangular block is slidably connected to the corresponding rectangular groove.

[0024] A method for using a Febuxostat raw material particle size detection device comprises the following steps:

[0025] S1. When in use, after the Febuxostat raw material is transported into the interior of the screening cylinder, the screening motor is started to rotate the support rod, so that the cam on the upper part of the support rod periodically contacts with the convex block on the upper part of the cross-shaped bracket, and then the cross-shaped bracket brings the screening cylinder to swing back and forth inside the detection tank to detect the Febuxostat raw material through the screening method;

[0026] S2. When the support rod rotates, the support rod drives the support cylinder at the bottom to rotate at the lower part of the screening cylinder. Under the cooperation of the movable groove and the movable block, the rotating support cylinder drives the concave adjustment cylinder and the crushing cylinder to rotate synchronously inside the screening cylinder. Due to the vibration screening process of the screening cylinder, large particles of febuxostat raw materials accumulate at the upper part of the febuxostat raw materials. At this time, the large particles of febuxostat raw materials screened are guided and transported to the inside of the crushing groove through the material guide chute on the side wall of the crushing cylinder;

[0027] S3. At the same time, since the adjusting shaft is slidably connected to the lower part of the supporting cylinder, the rotating supporting cylinder drives the adjusting shaft and the pad to rotate synchronously, and then the ball head push rod on the top of the pad is pressed against the surface of the wedge block at the bottom of the connecting ring in stages. At this time, the adjusting shaft drives the upper adjusting gear to slide inside the concave adjusting cylinder in stages. Under the cooperation of the adjusting gear and the threaded groove on the inner wall of the concave adjusting cylinder, when the adjusting shaft moves down, the concave adjusting cylinder rises. Then, under the action of the compression spring, the concave adjusting cylinder moves down and resets inside the supporting cylinder, and the adjusting shaft moves upward. Since the concave adjusting cylinder drives the crushing cylinder to move synchronously through the movable block, and the adjusting shaft drives the pad to move synchronously with the bracket and the exhaust plate, the exhaust plate and the crushing cylinder can move synchronously in opposite or relative directions, and the Febuxostat raw material agglomerated at the lower position of the Febuxostat raw material is crushed in stages;

[0028] S4, when the crushing cylinder rises and then moves down, the transmission rack rod meshes with the corresponding transmission gear, so that the transmission gear drives the crushing roller to rotate, and the two crushing rollers inside the crushing cylinder crush the large particles of febuxostat raw materials;

[0029] S5. When the exhaust plate moves downward, the piston rod at the bottom of the exhaust plate contacts the conical surface of the inner ring of the adjusting ring, so that the end of the piston rod is pressed to move toward the inside of the piston cylinder. At this time, the piston rod pushes the air inside the piston cylinder into the exhaust pipe position, and the exhaust pipe transports the gas to the top of the exhaust plate, so that the blown gas cleans the surface of the annular microporous screening net.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] In the present invention, by using the screening cylinder, the screening mechanism, the adjusting mechanism and other components in coordination, when the screening cylinder swings inside the detection tank to detect the Febuxostat API by the screening method, the screening mechanism and the adjusting mechanism cooperate to make the crushing cylinder and the exhaust plate move relative to or opposite to each other between the top and the bottom of the screening cylinder, so as to crush the agglomerated Febuxostat API, and at the same time, the crushing cylinder crushes the large particles of Febuxostat API, so as to ensure the detection of the Febuxostat API and crush the unqualified Febuxostat API into qualified products, thereby improving the functionality of the detection equipment.

[0032] In the present invention, through the coordinated use of components such as the detection tank body, the screening cylinder and the adjustment mechanism, when the exhaust plate moves down at the bottom of the screening cylinder, the piston rod at the bottom of the exhaust plate contacts the inner circle of the adjustment ring at the lower part of the inner wall of the detection tank body, so that the piston rod is compressed to push the internal gas of the piston cylinder into the exhaust pipe position, and then discharged from the top of the exhaust plate to clean the bottom of the screening cylinder, so that the screening cylinder can screen and crush the raw medicinal materials while achieving the anti-blocking effect, thereby ensuring the efficiency of the detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 It is a cross-sectional view of the detection tank body of the present invention;

[0034] Figure 2 It is a cross-sectional view of the detection tank body and the rear side position of the screening cylinder of the present invention;

[0035] Figure 3 It is a front cross-sectional view of the local position of the support cylinder and the adjustment shaft of the present invention;

[0036] Figure 4 It is a cross-sectional view of a local position of a pulverizing tube and a pulverizing roller of the present invention;

[0037] Figure 5 For the present invention Figure 4 A magnified view of the structure at center A;

[0038] Figure 6 It is a side cross-sectional view of a local position of a pulverizing tube and a transmission groove of the present invention;

[0039] Figure 7 A three-dimensional diagram of the position of the screening cylinder and the cross-shaped bracket of the present invention;

[0040] Figure 8 It is a bottom cross-sectional view of the exhaust plate and the local position of the backing plate of the present invention;

[0041] Fig. 9 It is a front cross-sectional view of the detection tank body and the screening cylinder position of the present invention.

[0042] In the figure: 1, detection tank; 2, screening motor; 3, support rod; 4, support cylinder; 5, rubber ring; 6, screening cylinder; 7, screening mechanism; 701, cross bracket; 702, convex block; 703, cam; 704, movable groove; 705, concave adjustment cylinder; 706, threaded groove; 707, compression spring; 708, movable block; 709, crushing cylinder; 710, guide chute; 711, crushing groove; 712, rotating rod; 713, crushing roller; 714, rotating rod; 715, crushing roller; 716, rotating rod; 717, rotating rod; 718, rotating rod; 719, rotating rod; 720, rotating rod; 721, rotating rod; 722, rotating rod; 723, rotating rod; 724, rotating rod; 725, rotating rod; 726, rotating rod; 727, rotating rod; 728, rotating rod; 729, rotating rod; 730, rotating rod; 731, rotating rod; 732, rotating rod; 733, rotating rod; 734, rotating rod; 735, rotating rod; 736, rotating rod; 737, rotating rod; 738, rotating rod; 739, rotating rod; 740, rotating rod; 741, rotating rod; 742, rotating rod; 743, rotating rod; 744, rotating rod; 745, rotating rod; 746, rotating rod; 747, rotating rod; 748, rotating rod; 749, rotating rod; 750, rotating rod; 751, rotating rod; 752, rotating rod; 753, rotating rod; 754, rotating rod; 755, rotating rod; 756, rotating rod; 757, 14. Transmission groove; 715. Transmission gear; 716. Transmission rack rod; 8. Adjustment mechanism; 801. Connecting ring; 802. Wedge block; 803. Adjustment shaft; 804. Groove; 805. Adjustment gear; 806. Pad; 807. Ball head push rod; 808. Synchronous bracket; 809. Piston cylinder; 810. Exhaust plate; 811. Piston rod; 812. Intake valve; 813. Exhaust pipe; 9. Adjustment ring; 10. Slide groove; 11. Slide rod. DETAILED DESCRIPTION

[0043] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technical personnel in this field without creative work are within the scope of protection of the present invention.

[0044] See also Figures 1 to 9 The present invention provides a technical solution: a Febuxostat raw material particle size detection device, comprising a detection tank body 1, a screening motor 2 is fixedly connected to the top of the detection tank body 1, a rotating end of the screening motor 2 penetrates the detection tank body 1 and is fixedly connected to a support rod 3, and a support cylinder 4 is fixedly connected to the bottom of the support rod 3. It should be noted that a loading port is provided at the top of the detection tank body 1, and a unloading port is provided at the bottom of the detection tank body 1.

[0045] The upper part of the inner wall of the detection tank body 1 is fixedly connected with a rubber ring 5, the inner ring of the rubber ring 5 is fixedly connected with a screening cylinder 6, the lower part of the support cylinder 4 is rotatably connected to the inner bottom surface of the screening cylinder 6, and a screening mechanism 7 is movably connected between the upper part of the screening cylinder 6 and the inside of the support cylinder 4. It should be noted that: through the setting of the rubber ring 5, when the screening cylinder 6 is swinging and screening inside the detection tank body 1, the rubber ring 5 can ensure the sealing effect between the upper part of the screening cylinder 6 and the inner wall of the detection tank body 1.

[0046] An adjusting mechanism 8 cooperating with the screening mechanism 7 is movably connected between the bottom of the screening cylinder 6 and the inside of the supporting cylinder 4 , and an adjusting ring 9 cooperating with the adjusting mechanism 8 is fixedly connected to the lower part of the inner wall of the detection tank body 1 .

[0047] Both sides of the detection tank body 1 are symmetrically provided with slide grooves 10, and a slide rod 11 is slidably connected inside the slide grooves 10, and the surface of the slide rod 11 is fixedly connected to the side wall of the screening cylinder 6. It should be noted that the stability of the swing of the screening cylinder 6 on the inner wall of the detection tank body 1 is improved by the cooperation between the slide rod 11 and the slide groove 10.

[0048] The screening mechanism 7 includes a cross-shaped bracket 701, which is fixedly connected to the top of the screening cylinder 6, a protrusion 702 is fixedly connected to the inner ring of the upper part of the cross-shaped bracket 701, and a cam 703 matching the protrusion 702 is fixedly sleeved on the upper part of the support rod 3. It should be noted that when the screening motor 2 rotates with the support rod 3 and the cam 703, the cam 703 contacts the protrusion 702 on the upper part of the cross-shaped bracket 701 in stages, so that the cross-shaped bracket 701 swings with the screening cylinder 6 inside the detection tank 1.

[0049] A movable groove 704 is provided on the middle side wall of the support tube 4, and a concave adjustment tube 705 is slidably connected to the upper part of the inner wall of the support tube 4. A threaded groove 706 that cooperates with the adjustment mechanism 8 is provided on the inner wall of the concave adjustment tube 705, and a compression spring 707 is fixedly connected between the top of the concave adjustment tube 705 and the inner top surface of the support tube 4.

[0050] A movable block 708 is fixedly connected to the side wall of the concave adjustment cylinder 705, and one end of the movable block 708 passes through the movable groove 704 and is fixedly connected to a crushing cylinder 709. One side of the crushing cylinder 709 overlaps with the side wall of the support cylinder 4, and the other side of the crushing cylinder 709 overlaps with the inner wall of the screening cylinder 6.

[0051] A material guiding chute 710 is provided on the side wall of the pulverizing cylinder 709, a pulverizing groove 711 cooperating with the material guiding chute 710 is vertically provided in the middle of the pulverizing cylinder 709, a rotating rod 712 is symmetrically rotatably connected to the inner wall of the pulverizing groove 711, a pulverizing roller 713 is fixedly sleeved on the middle part of the rotating rod 712, a transmission groove 714 cooperating with the end of the rotating rod 712 is provided on the inner wall of the pulverizing cylinder 709, the end of the rotating rod 712 extends to the inside of the transmission groove 714 and is fixedly sleeved with a transmission gear 715, a transmission rack rod 716 is vertically slidably connected to the inner wall of the transmission groove 714, and the lower part of the transmission rack rod 716 is movably inserted into the inner bottom surface of the transmission groove 714. It should be noted that the crushing groove 711 is set through the middle of the crushing cylinder 709. When the two crushing rollers 713 cooperate to crush the Febuxostat raw material, the crushed Febuxostat raw material falls from the crushing groove 711 onto the surface of the annular microporous screening net at the bottom of the screening cylinder 6.

[0052] In this embodiment, Figures 1 to 9 As shown, a sealed bearing is fixedly connected to the center of the bottom of the screening cylinder 6, and the outer ring of the lower part of the supporting cylinder 4 is fixedly connected to the inner ring of the sealed bearing.

[0053] The bottom of the screening cylinder 6 is fixedly connected with an annular microporous screening net, which is a metal net. It should be noted that the febuxostat raw materials that meet the requirements are screened out through the annular microporous screening net, and the febuxostat raw materials with large particles are detected.

[0054] In this embodiment, Figures 1 to 9 As shown, one side of the crushing cylinder 709 is set as an arc surface matched with the outer wall of the supporting cylinder 4, and the guide chute 710 is set along the rotation track of the crushing cylinder 709. It should be noted that: due to the vibration of the febuxostat raw material inside the screening cylinder 6, the large particles of febuxostat raw material will be at the upper position of the raw material. When the supporting cylinder 4 rotates with the crushing cylinder 709 inside the screening cylinder 6, the crushing cylinder 709 guides the large particles of febuxostat raw material into the crushing groove 711 through the guidance of the guide chute 710.

[0055] In this embodiment, Figures 1 to 9 As shown, a secondary sealed bearing is fixedly connected between the inner wall of the transmission groove 714 and the inner wall of the crushing groove 711, and the outer ring of the rotating rod 712 is fixedly connected to the inner ring of the secondary sealed bearing.

[0056] A guide groove is vertically provided on the inner wall of the transmission groove 714, and a guide rod is vertically fixedly connected inside the guide groove, and a guide block is fixedly connected to the side wall of the transmission rack rod 716, and the guide block is slidably connected to the surface of the corresponding guide rod, and the upper part of the guide rod is movably sleeved with a guide spring that matches the guide block. It should be noted that: when the movable block 708 moves up with the crushing tube 709, the guide spring presses the guide block to move the transmission rack rod 716 downward, and when the movable block 708 moves down with the crushing tube 709 again, the bottom of the transmission rack rod 716 is pressed and rises inside the transmission groove 714. In this process, the transmission rack rod 716 is meshed with the corresponding transmission gear 715, and the transmission gear 715 drives the rotating rod 712 and the crushing roller 713 to rotate, so as to crush the large-particle Febuxostat raw material; the directions of rotation of the two adjacent crushing rollers 713 are opposite.

[0057] In this embodiment, Figures 1 to 9 As shown, the adjustment mechanism 8 includes a connecting ring 801, which is fixedly connected to the bottom of the screening cylinder 6, the top of the connecting ring 801 overlaps the bottom of the supporting cylinder 4, and twelve wedge blocks 802 are fixedly connected to the bottom of the connecting ring 801 at equal intervals along the circumference.

[0058] The inner bottom of the support cylinder 4 is vertically slidably connected with an adjustment shaft 803, and the side wall of the upper part of the adjustment shaft 803 is symmetrically provided with a groove 804, and the inside of the groove 804 is rotatably connected with an adjustment gear 805 that matches the screening mechanism 7. It should be noted that: the lower part of the concave adjustment cylinder 705 is movably sleeved on the upper part of the adjustment shaft 803, and when the adjustment shaft 803 slides vertically inside the concave adjustment cylinder 705, the adjustment gear 805 on the upper part of the adjustment shaft 803 meshes with the inner wall of the thread groove 706 on the inner wall of the concave adjustment cylinder 705, so that the concave adjustment cylinder 705 moves in the opposite direction of the adjustment shaft 803.

[0059] The bottom of the adjusting shaft 803 passes through the connecting ring 801 and is fixedly connected with a pad 806 . The top of the pad 806 is fixedly connected with four ball head push rods 807 equidistantly along the circumference. The top of the ball head push rod 807 overlaps the surface of the corresponding wedge block 802 .

[0060] The side wall of the pad 806 is fixedly connected to a synchronous bracket 808, one end of the synchronous bracket 808 is fixedly connected to a piston cylinder 809, the top of the piston cylinder 809 is fixedly connected to an exhaust plate 810 that cooperates with the screening cylinder 6, the inside of the piston cylinder 809 is slidably connected to a piston rod 811 that cooperates with the adjustment ring 9, the bottom of the piston cylinder 809 away from the piston rod 811 is fixedly connected to an intake valve 812, the side of the piston cylinder 809 close to the intake valve 812 is symmetrically fixedly connected to an exhaust pipe 813, and the top of the exhaust pipe 813 is fixedly connected to the bottom of the exhaust plate 810. It should be noted that: the exhaust plate 810 and the crushing cylinder 709 are arranged at the same position of the screening cylinder 6; the inner ring of the adjusting ring 9 is set as a conical surface, when the piston rod 811 moves downward, the piston rod 811 contacts the conical surface and moves toward the inside of the piston cylinder 809; the top of the exhaust plate 810 is provided with an exhaust hole that cooperates with the exhaust pipe 813, so that the gas discharged from the exhaust hole position cleans the surface of the annular microporous screening net.

[0061] In this embodiment, Figures 1 to 9 As shown, a piston spring is fixedly connected between the end of the piston rod 811 and the inner wall of the piston cylinder 809, and a one-way valve is fixedly connected between the end of the exhaust pipe 813 and the surface of the piston cylinder 809. It should be noted that the intake valve 812 is set as an intake one-way valve, and the setting direction of the intake valve 812 is opposite to the setting direction of the one-way valve set in the exhaust pipe 813, so as to achieve the effect of one-way intake and exhaust.

[0062] In this embodiment, Figures 1 to 9 As shown, a vertical hole is provided at the bottom of the support tube 4, and the adjustment shaft 803 is movably inserted into the interior of the vertical hole. A rectangular block is symmetrically fixedly connected to the inner wall of the vertical hole, and a rectangular groove is symmetrically provided on the surface of the adjustment shaft 803, and the rectangular block is slidably connected to the interior of the corresponding rectangular groove. It should be noted that: through the cooperation between the rectangular block and the rectangular groove, the support tube 4 can rotate synchronously with the adjustment shaft 803 during the rotation process.

[0063] In this embodiment, Figures 1 to 9 As shown, a method for using a Febuxostat raw material particle size detection device comprises the following steps:

[0064] S1. When in use, after the Febuxostat raw material is transported into the interior of the screening cylinder 6, the screening motor 2 is started to rotate the support rod 3, so that the cam 703 on the upper part of the support rod 3 is periodically matched with the protrusion 702 on the upper part of the cross-shaped bracket 701, and then the cross-shaped bracket 701 reciprocates with the screening cylinder 6 in the detection tank body 1 to detect the Febuxostat raw material through the screening method;

[0065] S2. When the support rod 3 rotates, the support rod 3 drives the support cylinder 4 at the bottom to rotate at the lower part of the screening cylinder 6. Under the cooperation of the movable groove 704 and the movable block 708, the rotating support cylinder 4 drives the concave adjustment cylinder 705 and the crushing cylinder 709 to rotate synchronously inside the screening cylinder 6. During the vibration screening process of the screening cylinder 6, the large particles of febuxostat raw materials accumulate at the upper part of the febuxostat raw materials. At this time, the large particles of febuxostat raw materials screened are guided and transported to the inside of the crushing groove 711 through the material guide chute 710 on the side wall of the crushing cylinder 709;

[0066] S3. At the same time, since the adjusting shaft 803 is slidably connected to the lower part of the supporting tube 4, the rotating supporting tube 4 causes the adjusting shaft 803 to rotate synchronously with the pad 806. Then, the ball head push rod 807 on the top of the pad 806 is pressed against the surface of the wedge block 802 at the bottom of the connecting ring 801 in stages. At this time, the adjusting shaft 803 causes the upper adjusting gear 805 to slide inside the concave adjusting tube 705 in stages. Under the cooperation of the adjusting gear 805 and the threaded groove 706 on the inner wall of the concave adjusting tube 705, when the adjusting shaft 803 moves downward, the concave adjusting tube 705 is rotated. The cylinder 705 rises, and then under the action of the compression spring 707, the concave adjustment cylinder 705 moves down and resets inside the support cylinder 4, and the adjustment shaft 803 moves upward. Since the concave adjustment cylinder 705 moves synchronously with the crushing cylinder 709 through the movable block 708, and the adjustment shaft 803 moves synchronously with the pad 806, the synchronous bracket 808 and the exhaust plate 810, the exhaust plate 810 and the crushing cylinder 709 can move synchronously in opposite or relative directions, and the febuxostat raw material agglomerated at the lower position of the febuxostat raw material is crushed in stages;

[0067] S4, when the pulverizing cylinder 709 is in the process of rising and then moving down, the transmission rack rod 716 is meshed with the corresponding transmission gear 715, so that the transmission gear 715 drives the pulverizing roller 713 to rotate, and the two pulverizing rollers 713 inside the pulverizing cylinder 709 pulverize the large particles of febuxostat raw materials;

[0068] S5. When the exhaust plate 810 moves downward, the piston rod 811 at the bottom of the exhaust plate 810 contacts the conical surface of the inner ring of the adjusting ring 9, so that the end of the piston rod 811 is pressed and moves toward the inside of the piston cylinder 809. At this time, the piston rod 811 pushes the air inside the piston cylinder 809 into the exhaust pipe 813, and the exhaust pipe 813 transports the gas to the top of the exhaust plate 810, so that the blown gas cleans the surface of the annular microporous screening net.

[0069] The above shows and describes the basic principles, main features and advantages of the present invention. Technical personnel in this industry should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not used to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A Febuxostat raw material particle size detection device, comprising a detection tank (1), characterized in that: The top of the detection tank body (1) is fixedly connected to a screening motor (2); the rotating end of the screening motor (2) passes through the detection tank body (1) and is fixedly connected to a support rod (3); the bottom of the support rod (3) is fixedly connected to a support cylinder (4); A rubber ring (5) is fixedly connected to the upper part of the inner wall of the detection tank body (1), a screening cylinder (6) is fixedly connected to the inner ring of the rubber ring (5), the lower part of the support cylinder (4) is rotatably connected to the inner bottom surface of the screening cylinder (6), and a screening mechanism (7) is movably connected between the upper part of the screening cylinder (6) and the interior of the support cylinder (4); An adjusting mechanism (8) that cooperates with the screening mechanism (7) is movably connected between the bottom of the screening cylinder (6) and the interior of the supporting cylinder (4), and an adjusting ring (9) that cooperates with the adjusting mechanism (8) is fixedly connected to the lower part of the inner wall of the detection tank body (1); Both sides of the detection tank body (1) are symmetrically provided with slide grooves (10), the interior of the slide grooves (10) is slidably connected with a slide rod (11), and the surface of the slide rod (11) is fixedly connected to the side wall of the screening cylinder (6); The screening mechanism (7) comprises a cross-shaped bracket (701), the cross-shaped bracket (701) is fixedly connected to the top of the screening cylinder (6), the inner ring of the upper part of the cross-shaped bracket (701) is fixedly connected with a protrusion (702), and the upper part of the support rod (3) is fixedly sleeved with a cam (703) that matches the protrusion (702); A movable groove (704) is provided on the middle side wall of the support tube (4); a concave adjustment tube (705) is slidably connected to the upper part of the inner wall of the support tube (4); a threaded groove (706) cooperating with the adjustment mechanism (8) is provided on the inner wall of the concave adjustment tube (705); a compression spring (707) is fixedly connected between the top of the concave adjustment tube (705) and the inner top surface of the support tube (4); A movable block (708) is fixedly connected to the side wall of the concave regulating cylinder (705); one end of the movable block (708) passes through the movable groove (704) and is fixedly connected to a crushing cylinder (709); one side of the crushing cylinder (709) overlaps the side wall of the supporting cylinder (4); and the other side of the crushing cylinder (709) overlaps the inner wall of the screening cylinder (6); A material guiding chute (710) is provided on the side wall of the pulverizing cylinder (709); a pulverizing groove (711) matching with the material guiding chute (710) is vertically provided in the middle of the pulverizing cylinder (709); a rotating rod (712) is symmetrically rotatably connected to the inner wall of the pulverizing groove (711); a pulverizing roller (713) is fixedly sleeved on the middle of the rotating rod (712); a transmission groove (714) matching with the end of the rotating rod (712) is provided on the inner wall of the pulverizing cylinder (709); a transmission gear (715) is fixedly sleeved on the end of the rotating rod (712) extending to the inside of the transmission groove (714); a transmission rack rod (716) is vertically slidably connected to the inner wall of the transmission groove (714); the lower part of the transmission rack rod (716) is movably inserted into the inner bottom surface of the transmission groove (714).

2. A Febuxostat raw material particle size detection device according to claim 1, characterized in that: A sealed bearing is fixedly connected at the center of the bottom of the screening cylinder (6), and the outer ring of the lower part of the support cylinder (4) is fixedly connected to the inner ring of the sealed bearing; An annular microporous screening net is fixedly connected to the bottom of the screening cylinder (6), and the annular microporous screening net is configured as a metal net.

3. A Febuxostat raw material particle size detection device according to claim 2, characterized in that: One side of the pulverizing cylinder (709) is provided as an arc-shaped surface that matches the outer wall of the supporting cylinder (4), and the material guiding chute (710) is provided along the direction of the rotation trajectory of the pulverizing cylinder (709).

4. A Febuxostat raw material particle size detection device according to claim 3, characterized in that: A secondary sealed bearing is fixedly connected between the inner wall of the transmission groove (714) and the inner wall of the crushing groove (711), and the outer ring of the rotating rod (712) is fixedly connected to the inner ring of the secondary sealed bearing; A guide groove is vertically provided on the inner wall of the transmission groove (714), a guide rod is vertically fixedly connected to the inside of the guide groove, a guide block is fixedly connected to the side wall of the transmission rack rod (716), the guide block is slidably connected to the surface corresponding to the guide rod, and a guide spring that cooperates with the guide block is movably sleeved on the upper part of the guide rod.

5. The Febuxostat raw material particle size detection device according to claim 4, characterized in that: The adjustment mechanism (8) comprises a connecting ring (801), the connecting ring (801) is fixedly connected to the bottom of the screening cylinder (6), the top of the connecting ring (801) overlaps the bottom of the supporting cylinder (4), and twelve wedge blocks (802) are fixedly connected to the bottom of the connecting ring (801) at equal intervals along the circumference; The inner bottom of the support cylinder (4) is vertically slidably connected to an adjustment shaft (803), the upper side wall of the adjustment shaft (803) is symmetrically provided with grooves (804), and the interior of the groove (804) is rotatably connected to an adjustment gear (805) that cooperates with the screening mechanism (7); The bottom of the adjusting shaft (803) passes through the connecting ring (801) and is fixedly connected to a backing plate (806); the top of the backing plate (806) is fixedly connected to four ball head push rods (807) at equal intervals along the circumference; the top of the ball head push rods (807) overlaps the surface of the corresponding wedge block (802); A synchronous bracket (808) is fixedly connected to the side wall of the pad (806), one end of the synchronous bracket (808) is fixedly connected to a piston cylinder (809), the top of the piston cylinder (809) is fixedly connected to an exhaust plate (810) that matches the screening cylinder (6), the interior of the piston cylinder (809) is slidably connected to a piston rod (811) that matches the adjustment ring (9), the bottom of the piston cylinder (809) away from the piston rod (811) is fixedly connected to an intake valve (812), the side of the piston cylinder (809) close to the intake valve (812) is symmetrically fixedly connected to an exhaust pipe (813), and the top of the exhaust pipe (813) is fixedly connected to the bottom of the exhaust plate (810).

6. The device for detecting particle size of febuxostat raw material according to claim 5, characterized in that: A piston spring is fixedly connected between the end of the piston rod (811) and the inner wall of the piston cylinder (809), and a one-way valve is fixedly connected between the end of the exhaust pipe (813) and the surface of the piston cylinder (809).

7. The device for detecting particle size of febuxostat raw material according to claim 6, characterized in that: A vertical hole is provided at the bottom of the support cylinder (4), the adjustment shaft (803) is movably inserted into the interior of the vertical hole, a rectangular block is symmetrically fixedly connected to the inner wall of the vertical hole, and a rectangular groove is symmetrically provided on the surface of the adjustment shaft (803), and the rectangular block is slidably connected to the interior of the corresponding rectangular groove.

8. The method for using the febuxostat raw material particle size detection device according to claim 7, comprising the following steps: S1. During use, after the Febuxostat raw material is conveyed into the interior of the screening cylinder (6), the screening motor (2) is started to rotate the support rod (3), so that the cam (703) on the upper part of the support rod (3) periodically contacts with the protrusion (702) on the upper part of the cross-shaped bracket (701), and then the cross-shaped bracket (701) and the screening cylinder (6) are reciprocated and swung inside the detection tank (1) to detect the Febuxostat raw material through a screening method; S2, when the support rod (3) rotates, the support rod (3) drives the support cylinder (4) at the bottom to rotate at the bottom of the screening cylinder (6), and under the cooperation of the movable groove (704) and the movable block (708), the rotating support cylinder (4) drives the concave adjustment cylinder (705) and the crushing cylinder (709) to rotate synchronously inside the screening cylinder (6). During the vibration screening process of the screening cylinder (6), large particles of febuxostat raw materials accumulate at the upper part of the febuxostat raw materials. At this time, the large particles of febuxostat raw materials screened are guided and transported to the inside of the crushing groove (711) through the material guide chute (710) on the side wall of the crushing cylinder (709); S3. At the same time, since the adjustment shaft (803) is slidably connected to the lower part of the support tube (4), the rotating support tube (4) causes the adjustment shaft (803) and the pad (806) to rotate synchronously. Then, the ball head push rod (807) at the top of the pad (806) is pressed against the surface of the wedge block (802) at the bottom of the connecting ring (801) in stages. At this time, the adjustment shaft (803) causes the upper adjustment gear (805) to slide inside the concave adjustment tube (705) in stages. Under the cooperation of the adjustment gear (805) and the threaded groove (706) on the inner wall of the concave adjustment tube (705), when the adjustment shaft (803) moves downward, the concave adjustment tube (705) is rotated. The adjusting cylinder (705) rises, and then under the action of the compression spring (707), the concave adjusting cylinder (705) moves downward and resets inside the supporting cylinder (4), while the adjusting shaft (803) moves upward. Since the concave adjusting cylinder (705) moves synchronously with the crushing cylinder (709) through the movable block (708), and the adjusting shaft (803) moves synchronously with the pad (806) and the bracket (808) and the exhaust plate (810), the exhaust plate (810) and the crushing cylinder (709) can move synchronously in opposite directions or relative to each other, and the febuxostat raw material agglomerated at the lower part of the febuxostat raw material is crushed in stages. S4, when the pulverizing cylinder (709) is raised and then moves down, the transmission rack rod (716) meshes with the corresponding transmission gear (715), so that the transmission gear (715) drives the pulverizing roller (713) to rotate, and the two pulverizing rollers (713) inside the pulverizing cylinder (709) pulverize the large particles of febuxostat raw material; S5. When the exhaust plate (810) moves downward, the piston rod (811) at the bottom of the exhaust plate (810) contacts the conical surface of the inner ring of the adjustment ring (9), so that the end of the piston rod (811) is pressed and moves toward the inside of the piston cylinder (809). At this time, the piston rod (811) pushes the air inside the piston cylinder (809) into the exhaust pipe (813), and the exhaust pipe (813) transports the gas into the top of the exhaust plate (810), so that the blown gas cleans the surface of the annular microporous screening net.

Images