Microreactor

Abstract

The present application discloses a microreactor, which belongs to the field of microfluid technology. The microreactor includes: a microfluid bifurcated structure, including a bent pipe, a straight pipe and a bifurcated pipe located in the same plane, the liquid outlet end of the bent pipe is connected to the liquid inlet end of the straight pipe, and the liquid outlet end of the straight pipe is connected to the liquid inlet end of the bifurcated pipe; an auxiliary structure, which is arranged in the straight pipe at intervals along the width direction of the straight pipe, and extends along the axial direction and height direction of the straight pipe, the height direction is perpendicular to the plane, and the width direction is perpendicular to the axial direction and parallel to the plane. The present application can improve the fluid equalization effect, thereby improving the consistency of the retention time of the fluid in the parallel microchannels, and thus improving the reaction effect of the microreactor.

Description

Technical Field

[0001] The present application belongs to the field of microfluid technology, and in particular to a microreactor. Background Art

[0002] Microreactors are widely used in chemical synthesis. For chemical reactions, the use of microreactors means faster diffusion speed, shorter reaction time, better heat transfer effect and higher chemical reaction selectivity.

[0003] Microreactors mainly use bifurcated structures to achieve fluid distribution (the bifurcated structure distributes a certain amount of fluid to a series of parallel microchannels) to increase the fluid flux and yield. However, the bifurcated structure has a curved channel. When the fluid flows through the curved channel, it will be affected by the inertial force and deviate to the outside of the curved channel, causing uneven fluid distribution, which in turn leads to different retention times of the fluid in the parallel microchannels, affecting the reaction effect of the microreactor. Summary of the invention

[0004] The present application aims to solve at least one of the technical problems existing in the related art. To this end, the present application proposes a microreactor that can improve the fluid equalization effect, thereby improving the consistency of the retention time of the fluid in the parallel microchannels, and further improving the reaction effect of the microreactor.

[0005] The present application provides a microreactor, comprising:

[0006] A microfluidic bifurcated structure, comprising a bent pipe, a straight pipe and a bifurcated pipe located in the same plane, wherein the liquid outlet of the bent pipe is connected to the liquid inlet of the straight pipe, and the liquid outlet of the straight pipe is connected to the liquid inlet of the bifurcated pipe;

[0007] The auxiliary structure is arranged in the linear pipeline at intervals along the width direction of the linear pipeline and extends along the axial direction and height direction of the linear pipeline, the height direction is perpendicular to the plane, and the width direction is perpendicular to the axial direction and parallel to the plane.

[0008] According to one embodiment of the present application, the auxiliary structure is located between a first center position and a first position in the width direction of the straight pipe, and the first position is offset by a first distance in the width direction away from the curved pipe compared to the first center position.

[0009] According to one embodiment of the present application, the first distance is no greater than 10% of the width of the linear pipe.

[0010] According to one embodiment of the present application, the width of the auxiliary structure is 10%-20% of the width of the linear pipe.

[0011] According to one embodiment of the present application, the auxiliary structure is located between the second axial position and the third axial position of the straight pipe, the second position is offset by a second distance in the axial direction toward the curved pipe compared to the second center position, and the third position is offset by a third distance in the axial direction toward the bifurcated pipe compared to the second center position, and the second center position is the axial center position of the straight pipe.

[0012] According to one embodiment of the present application, the second distance and the third distance are respectively no greater than 10% of the length of the linear pipe along the axial direction.

[0013] According to one embodiment of the present application, the length of the auxiliary structure along the axial direction is 40%-70% of the length of the straight pipe along the axial direction.

[0014] According to one embodiment of the present application, the auxiliary structure is located between a fourth position and a fifth position in the height direction of the linear pipe, the fourth position is offset upward by a fourth distance compared to the third center position, and the fifth position is offset downward by a fifth distance compared to the third center position, and the third center position is the center position of the linear pipe in the height direction.

[0015] According to one embodiment of the present application, the fourth distance and the fifth distance are respectively no greater than 10% of the height of the linear pipe.

[0016] According to one embodiment of the present application, the height of the auxiliary structure is 50%-100% of the height of the linear pipe.

[0017] According to one embodiment of the present application, the orthographic projection of the auxiliary structure along the height direction is rectangular, elliptical or rhombus-shaped;

[0018] The material of the auxiliary structure includes glass, photoresist, silicon or PDMS.

[0019] According to one embodiment of the present application, the microreactor comprises a plurality of the microfluidic bifurcation structures, the plurality of the microfluidic bifurcation structures constitute N-level microfluidic bifurcation structures, N≥2, the liquid outlet end of the bifurcated pipeline of the upper-level microfluidic bifurcation structure is connected to the liquid inlet end of the bent pipeline of the lower-level microfluidic bifurcation structure;

[0020] The auxiliary structure is provided in the first m levels of microfluidic bifurcation structures, m≤N.

[0021] The above one or more technical solutions in the embodiments of the present application have at least one of the following technical effects:

[0022] By arranging auxiliary structures at intervals along the width direction in the straight pipe, when the fluid enters the straight pipe through the meandering pipe, the fluid is effectively restricted from deviating toward the outside of the meandering pipe (i.e., toward the straight pipe in the width direction away from the meandering pipe), thereby improving the fluid distribution effect, thereby improving the consistency of the retention time of the fluid in the parallel micro-channels, and further improving the reaction effect of the micro-reactor; the auxiliary structure is arranged in the microfluidic bifurcation structure, does not change the structure of the microfluidic bifurcation structure itself, and does not destroy the functionality of the microfluidic bifurcation structure itself, and can be applied to different micro-reactors, with good versatility.

[0023] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0025] Figure 1 This is one of the structural schematic diagrams of the microreactor provided in the embodiments of the present application;

[0026] Figure 2 is a cross-sectional schematic diagram of a linear pipeline and auxiliary structures in a microreactor provided in an embodiment of the present application;

[0027] Figure 3 is a schematic structural diagram of a linear pipeline and auxiliary structures in a microreactor provided in an embodiment of the present application;

[0028] Figure 4 This is the second structural schematic diagram of the microreactor provided in the embodiment of the present application;

[0029] Figure 5 This is the third structural schematic diagram of the microreactor provided in the embodiments of the present application.

[0030] Reference numerals:

[0031] Microfluidic bifurcation structure 1, curved channel 2, straight channel 3, bifurcated channel 4, auxiliary structure 5, axial direction X, width direction W, height direction H, height h1 of straight channel 3, height h2 of auxiliary structure 5, length x1 of straight channel 3, length x2 of auxiliary structure 5, width w1 of straight channel 3, width w2 of auxiliary structure 5, first-level microfluidic bifurcation structure 1a, second-level microfluidic bifurcation structure 1b, third-level microfluidic bifurcation structure 1c. DETAILED DESCRIPTION

[0032] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and cannot be understood as limiting the present application.

[0033] The microreactor provided in the embodiments of the present application is described below with reference to the accompanying drawings.

[0034] Figure 1 This is a schematic diagram of the structure of a microreactor provided in an embodiment of the present application.

[0035] Combination Figure 1 As shown, the microreactor provided in the embodiment of the present application includes a microfluidic bifurcation structure 1 and an auxiliary structure 5 .

[0036] The microfluidic bifurcated structure 1 may include a meandering pipe 2. The meandering pipe 2 includes a liquid inlet end for inflow of fluid, and a liquid outlet end for outflow of fluid. The liquid inlet end of the meandering pipe 2 is the liquid inlet end of the microfluidic bifurcated structure 1, and the fluid flows into the meandering pipe 2 through the liquid inlet end of the microfluidic bifurcated structure 1. The bending direction of the meandering pipe 2 may be parallel to the horizontal plane, that is, the cross section of the meandering pipe 2 parallel to the horizontal plane is meandering. The cross section of the meandering pipe 2 perpendicular to the horizontal plane may be rectangular.

[0037] The microfluidic bifurcated structure 1 may also include a straight pipe 3. The straight pipe 3 includes a liquid inlet end for the fluid to flow in, and a liquid outlet end for the fluid to flow out. The liquid inlet end of the straight pipe 3 is connected to the liquid outlet end of the curved pipe 2, and the fluid flows out of the liquid outlet end of the curved pipe 2 and then flows into the straight pipe 3 through the liquid inlet end of the straight pipe 3. The straight pipe 3 and the curved pipe 2 are located in the same plane, such as a horizontal plane. The cross-section of the straight pipe 3 parallel to the horizontal plane is rectangular, and the cross-section of the straight pipe 3 perpendicular to the horizontal plane may also be rectangular. Since the curved pipe 2 is curved, the curved pipe 2 presents a certain bending angle compared to the straight pipe 3, for example Figure 1 The curved pipe 2 is bent at 90° compared to the straight pipe 3.

[0038] The microfluidic bifurcated structure 1 may also include a bifurcated pipe 4. The bifurcated pipe 4 includes a liquid inlet end for the inflow of fluid, and a liquid outlet end for the outflow of fluid. The liquid inlet end of the bifurcated pipe 4 is connected to the liquid outlet end of the linear pipe 3, and the liquid outlet end of the bifurcated pipe 4 is the liquid outlet end of the microfluidic bifurcated structure 1. After the fluid flows out from the liquid outlet end of the linear pipe 3, it flows into the bifurcated pipe 4 through the liquid inlet end of the bifurcated pipe 4, and then flows out through the liquid outlet end of the microfluidic bifurcated structure 1. The bifurcated pipe 4, the bent pipe 2 and the linear pipe 3 are located in the same plane, such as a horizontal plane. The bent pipe 2, the linear pipe 3 and the bifurcated pipe 4 are arranged in sequence along the axial direction X of the linear pipe 3. The axial direction X is parallel to the plane (such as a horizontal plane) where the bifurcated pipe 4, the bent pipe 2 and the linear pipe 3 are located.

[0039] The bifurcated pipe 4 may include p parallel micro-pipes, where p ≥ 2. The p parallel micro-pipes, the curved pipe 2, and the straight pipe 3 are located in the same plane, such as a horizontal plane. Each parallel micro-pipe has a liquid outlet, that is, the microfluidic bifurcated structure 1 has p liquid outlets. The fluid flowing into the bifurcated pipe 4 is respectively transmitted to the p parallel micro-pipes to divide the fluid into p parts, and then flows out through the p liquid outlets of the microfluidic bifurcated structure 1. For example Figure 1 As shown, the bifurcated channel 4 includes two parallel microchannels (ie, p=2) to divide the fluid flowing into the bifurcated channel 4 into two parts, which then flow out through the two liquid outlet ends of the microfluidic bifurcated structure 1 respectively.

[0040] like Figure 1 As shown, the auxiliary structure 5 is arranged in the straight pipe 3 at intervals along the width direction W of the straight pipe 3. In other words, the auxiliary structure 5 is located inside the straight pipe 3, and there is a gap between the two sides of the auxiliary structure 5 along the width direction W and the pipe side wall of the straight pipe 3. Among them, the width direction W is parallel to the plane (such as the horizontal plane) where the bifurcated pipe 4, the bent pipe 2 and the straight pipe 3 are located, and the axial direction X is perpendicular to the width direction W. Figure 2 As shown ( Figure 2 is a cross-sectional schematic diagram of the straight pipe 3 and the auxiliary structure 5 parallel to the height direction and the width direction), the auxiliary structure 5 extends along the axial direction X and the height direction H of the straight pipe 3. The auxiliary structure 5 extends along the axial direction X, but does not exceed the two ends of the straight pipe 3 along the axial direction X, so that the auxiliary structure 5 is located inside the straight pipe 3. The auxiliary structure 5 can extend to the bottom and / or top of the straight pipe 3 along the height direction H. The height direction H is perpendicular to the plane (such as the horizontal plane) where the bifurcated pipe 4, the bent pipe 2 and the straight pipe 3 are located.

[0041] In microreactors, bifurcated structures are used to achieve fluid uniformity, which is an easy-to-repeat and scalable way of equalization into arrays. However, bifurcated structures cannot guarantee that the fluid flow shape is fully developed over a short distance, resulting in uneven final fluid distribution. In particular, as the flow rate increases, the influence of the fluid inertia force increases, and the equalization ability of the bifurcated structure will also decrease.

[0042] In practical applications, many chemical reactions have very short retention times, which requires very high flow rates. At the same time, in order to increase production, a multi-stage parallel bifurcation structure is required in the microreactor. In this high flow situation, the slightly asymmetric velocity distribution at the front bifurcation structure will produce a significant uneven distribution after passing through the multi-stage bifurcation structure. In order to improve the balancing ability of the bifurcation structure, the relevant technology optimizes the geometric parameters of the bifurcation structure and improves its balancing ability, but the unevenness of the flow distribution under high flow conditions is still large.

[0043] Based on this, in this embodiment, an auxiliary structure 5 is arranged in the microfluidic bifurcated structure 1, and the auxiliary structure 5 is arranged in the straight pipe 3 at intervals along the width direction W, so that when the fluid flows from the bent pipe 2 into the straight pipe 3, the auxiliary structure 5 can control the lateral force received by the fluid when passing through the bent pipe 2, and limit the fluid from deviating toward the outside of the bent pipe 2 (that is, toward the straight pipe 3 away from the width direction W of the bent pipe 2), thereby controlling the symmetry of the fluid flow field, improving the equal distribution effect of the fluid in the bifurcated pipe 4, and still achieving good fluid equal distribution under high flow, and improving the consistency of the retention time of the fluid in the parallel micro-pipes, thereby improving the reaction effect of the microreactor. Moreover, the auxiliary structure 5 extends along the axial direction X and the height direction H, and the width of the auxiliary structure 5 in the width direction W is very small, so as to ensure that the strength of the auxiliary structure 5 can resist the impact of the lateral force when the fluid passes through the bent pipe 2, and at the same time try not to affect the passage efficiency of the fluid in the straight pipe 3.

[0044] In some embodiments, the auxiliary structure 5 of the microreactor is located between a first center position and a first position in the width direction W of the straight pipe 3 , and the first position is offset by a first distance away from the width direction W of the curved pipe 2 compared to the first center position.

[0045] The first center position is the center position of the straight pipe 3 along the width direction W, that is, the auxiliary structure 5 can be located at the center position of the straight pipe 3 in the width direction W. The auxiliary structure 5 can also be slightly offset in the width direction W away from the curved pipe 2, such as the auxiliary structure 5 can be located at the first position. Since the curved pipe 2 is curved compared to the straight pipe 3, the curved pipe 2 is located on one side of the straight pipe 3 along the width direction W. For example Figure 1As shown, in the width direction W, the curved pipe 2 is located on the right side of the straight pipe 3, the first position is located on the left side of the first center position, and the distance between the first position and the first center position is the first distance. The auxiliary structure 5 can be slightly offset to the left in the straight pipe 3, but cannot exceed the first position.

[0046] When the fluid enters the straight pipe 3 from the curved pipe 2, the fluid is deviated to the left side of the straight pipe 3 due to the inertial force, resulting in a larger flow rate on the left side of the straight pipe 3. In this embodiment, the auxiliary structure 5 is slightly offset to the left side compared to the first center position, which can further improve the fluid distribution effect.

[0047] In some embodiments, the first distance is not greater than 10% of the width of the straight pipe 3, that is, the maximum distance that the auxiliary structure 5 is offset from the first center position in the width direction W away from the curved pipe 2 does not exceed 10% of the width w1 of the straight pipe 3.

[0048] In some embodiments, the width w2 of the auxiliary structure 5 is 10%-20% of the width w1 of the straight pipe 3 , that is, w2 can be set to 10% w1-20% w1.

[0049] Combination Figure 3 As shown, the width w2 of the auxiliary structure 5 can be adaptively adjusted according to the width w1 of the straight pipe 3 in which it is located. The width w2 of the auxiliary structure 5 can be positively correlated with the width w1 of the straight pipe 3. The larger the width w1 of the straight pipe 3, the greater the fluid flow in the straight pipe 3, and the larger the width w2 of the auxiliary structure 5 can be, so as to ensure that its strength can resist the impact of the lateral force when the fluid passes through the curved pipe 2. Compared with the width w1 of the straight pipe 3, the width w2 of the auxiliary structure 5 is set smaller, so as to optimize the equal distribution effect of the fluid while minimizing the influence on the passage efficiency of the fluid.

[0050] In some embodiments, the auxiliary structure 5 is located between a second position and a third position of the axial direction X of the straight pipe 3, the second position is offset by a second distance from the second center position toward the axial direction X close to the curved pipe 2, and the third position is offset by a third distance from the second center position toward the axial direction X close to the forked pipe 4, and the second center position is the center position of the axial direction X of the straight pipe 3.

[0051] The length x2 of the auxiliary structure 5 (i.e., the length of the auxiliary structure 5 along the axial direction X) is less than the length x1 of the straight pipe 3 (i.e., the length of the straight pipe 3 along the axial direction X). The second center position is the center position of the straight pipe 3 along the axial direction X, and the auxiliary structure 5 can be located at the center position of the axial direction X of the straight pipe 3. The auxiliary structure 5 can also be slightly offset toward the axial direction X of the curved pipe 2, such as the auxiliary structure 5 can be located at the second position, but not exceeding the second position. The auxiliary structure 5 can also be slightly offset toward the axial direction X of the bifurcated pipe 4, such as the auxiliary structure 5 can be located at the third position, but not exceeding the third position.

[0052] The position of the auxiliary structure 5 in the axial direction X will also affect the fluid distribution effect. The closer the auxiliary structure 5 is to the second position in the axial direction X, that is, the closer the auxiliary structure 5 is to the bent pipe 2 in the axial direction X, the better the fluid distribution effect can be.

[0053] In some embodiments, the second distance and the third distance are not greater than 10% of the length x1 of the straight pipe 3, that is, the maximum distance of the axial X offset of the auxiliary structure 5 toward the curved pipe 2 compared to the second center position does not exceed 10% of the length x1 of the straight pipe 3, and the maximum distance of the axial X offset of the auxiliary structure 5 toward the forked pipe 4 compared to the second center position does not exceed 10% of the length x1 of the straight pipe 3.

[0054] In some embodiments, the length x2 of the auxiliary structure 5 is 40%-70% of the length x1 of the straight pipe 3, that is, x2 can be set to 40%x1-70%x1.

[0055] Combination Figure 3 As shown, the length x2 of the auxiliary structure 5 can be adaptively adjusted according to the length x1 of the straight pipe 3 in which it is located. The length x2 of the auxiliary structure 5 can be positively correlated with the length x1 of the straight pipe 3. The longer the length x1 of the straight pipe 3 is, the longer the length x2 of the auxiliary structure 5 can be, so as to ensure that its strength can resist the impact of the lateral force when the fluid passes through the curved pipe 2, and further improve the effect of evenly distributing the fluid.

[0056] In some embodiments, the auxiliary structure 5 is located between a fourth position and a fifth position in the height direction H of the linear pipe 3, the fourth position is offset upward by a fourth distance compared to the third center position, and the fifth position is offset downward by a fifth distance compared to the third center position, and the third center position is the center position in the height direction H of the linear pipe 3.

[0057] The height h2 of the auxiliary structure 5 may be less than or equal to the height h1 of the straight pipe 3. When the height h2 of the auxiliary structure 5 is less than the height h1 of the straight pipe 3, the auxiliary structure 5 may be located at the third center position, that is, the auxiliary structure 5 may be located at the center position of the height direction H of the straight pipe 3. The auxiliary structure 5 may also be slightly offset upward along the height direction H, such as the auxiliary structure 5 may be located at the fourth position. The auxiliary structure 5 may also be slightly offset downward along the height direction H, such as the auxiliary structure 5 may be located at the fifth position.

[0058] In some embodiments, the fourth distance and the fifth distance are not greater than 10% of the height h1 of the straight pipe 3, that is, the maximum distance that the auxiliary structure 5 is offset upward in the height direction H compared to the third center position does not exceed 10% of the height h1 of the straight pipe 3, and the maximum distance that the auxiliary structure 5 is offset downward in the height direction H compared to the third center position does not exceed 10% of the height h1 of the straight pipe 3.

[0059] In some embodiments, the height h2 of the auxiliary structure 5 is 50%-100% of the height h1 of the straight pipe 3 , that is, h2 can be set to 50% h1-100% h1.

[0060] Combination Figure 2 As shown, the height h2 of the auxiliary structure 5 can be adaptively adjusted according to the height h1 of the straight pipe 3 in which it is located. The height h2 of the auxiliary structure 5 can be positively correlated with the height h1 of the straight pipe 3. The larger the height h1 of the straight pipe 3, the larger the height h2 of the auxiliary structure 5 can be, so as to ensure that its strength can resist the impact of the lateral force when the fluid passes through the curved pipe 2. The height h2 of the auxiliary structure 5 can be set larger, such as the height h2 of the auxiliary structure 5 is the same as the height h1 of the straight pipe 3, so as to space the fluid in the straight pipe 3 along the width direction W, further optimize the equal distribution effect of the fluid, and reduce the process complexity of the auxiliary structure 5.

[0061] In some embodiments, the orthographic projection of the auxiliary structure 5 along the height direction H may be rectangular, elliptical, or diamond-shaped, etc., that is, the cross-section of the auxiliary structure 5 along the width direction W may be rectangular, elliptical, or diamond-shaped, etc.

[0062] When the width w2 of the auxiliary structure 5 is small (e.g., the width w2 of the auxiliary structure 5 is 10%-20% of the width w1 of the linear pipe 3), the cross-sectional shape of the auxiliary structure 5 along the width direction W is not specifically limited. The cross-sectional shape of the auxiliary structure 5 along the width direction W is regular (e.g., rectangular), which facilitates the manufacturing and processing of the auxiliary structure 5 and simplifies the process complexity.

[0063] In some embodiments, the material of the microfluidic bifurcated structure 1 may include one or more combinations of glass, photoresist, silicon, and PDMS (polydimethylsiloxane). The material of the bottom of the microfluidic bifurcated structure 1 may include silicon, glass, photoresist, etc., the material of the pipeline sidewall of the microfluidic bifurcated structure 1 may include silicon, glass, photoresist, and PDMS, etc., and the material of the top of the microfluidic bifurcated structure 1 may include glass, silicon, photoresist, etc. Among them, the pipeline sidewall of the microfluidic bifurcated structure 1 includes the pipeline sidewall of the bifurcated pipeline 4, the pipeline sidewall of the bent pipeline 2, and the pipeline sidewall of the straight pipeline 3. The bottom of the microfluidic bifurcated structure 1 includes the bottom of the bifurcated pipeline 4, the bottom of the bent pipeline 2, and the bottom of the straight pipeline 3. The top of the microfluidic bifurcated structure 1 includes the top of the bifurcated pipeline 4, the top of the bent pipeline 2, and the top of the straight pipeline 3.

[0064] The materials of the pipeline sidewall, top and bottom of the microfluidic bifurcated structure 1 may be the same or different. For example, the materials of the bottom, top and pipeline sidewall of the microfluidic bifurcated structure 1 are the same (e.g., the bottom, top and pipeline sidewall of the microfluidic bifurcated structure 1 are all glass); the materials of the bottom and pipeline sidewall of the microfluidic bifurcated structure 1 are the same (e.g., the bottom and pipeline sidewall of the microfluidic bifurcated structure 1 are all silicon), and the materials of the top of the microfluidic bifurcated structure 1 are different (e.g., the top of the microfluidic bifurcated structure 1 is glass); the materials of the bottom and top of the microfluidic bifurcated structure 1 are the same (e.g., the bottom and top of the microfluidic bifurcated structure 1 are both glass), and the materials of the pipeline sidewall of the microfluidic bifurcated structure 1 are different (e.g., the pipeline sidewall of the microfluidic bifurcated structure 1 is photoresist or PDMS); the materials of the top, bottom and pipeline sidewall of the microfluidic bifurcated structure 1 are different (e.g., the top of the microfluidic bifurcated structure 1 is glass, the bottom is silicon, and the pipeline sidewall is photoresist or PDMS).

[0065] In some embodiments, the material of the auxiliary structure 5 may include glass, photoresist, silicon or PDMS, etc. The material of the auxiliary structure 5 may be the same as the material of the pipeline sidewall of the microfluidic bifurcating structure 1, and the auxiliary structure 5 and the pipeline sidewall of the microfluidic bifurcating structure 1 may be an integrally formed structure, that is, the auxiliary structure 5 and the pipeline sidewall of the microfluidic bifurcating structure 1 may be formed in the same process step.

[0066] In some embodiments, the microreactor may include multiple microfluidic bifurcation structures 1, and the multiple microfluidic bifurcation structures 1 can constitute N levels of microfluidic bifurcation structures, N≥2, and the liquid outlet end of the bifurcated pipe 4 of the upper-level microfluidic bifurcation structure is connected to the liquid inlet end of the curved pipe 2 of the next-level microfluidic bifurcation structure; an auxiliary structure 5 is provided in the first m levels of microfluidic bifurcation structures, m≤N.

[0067] The N-level microfluidic bifurcation structure includes the first-level microfluidic bifurcation structure to the N-th level microfluidic bifurcation structure. The bifurcated pipe 4 in each microfluidic bifurcation structure 1 includes p parallel microchannels. The number of the first-level microfluidic bifurcation structure is one, that is, one microfluidic bifurcation structure 1 is a first-level microfluidic bifurcation structure, and the first-level microfluidic bifurcation structure has p liquid outlets. The number of the second-level microfluidic bifurcation structures is p, that is, p microfluidic bifurcation structures 1 are second-level microfluidic bifurcation structures. The liquid inlet ends of the p second-level microfluidic bifurcation structures are connected to the p liquid outlet ends of the first-level microfluidic bifurcation structure in a one-to-one correspondence. The p second-level microfluidic bifurcation structures have p 2 The number of the third-level microfluidic bifurcation structure is p 2 p 2 The microfluidic bifurcation structure 1 is a third-level microfluidic bifurcation structure. 2 The liquid inlet end of the third-stage microfluidic bifurcation structure is connected to the p second-stage microfluidic bifurcation structure 2 The liquid outlets are connected one by one. Similarly, the number of the N-1th level microfluidic bifurcation structures is p N-2 p N-2 The microfluidic bifurcation structure 1 is the N-1th level microfluidic bifurcation structure, having p N-1 The number of N-th level microfluidic bifurcation structures is p N-1 p N-1 The microfluidic bifurcation structure 1 is the Nth-level microfluidic bifurcation structure. N-1 The inlet end and p N-2 p of the N-1th level structure N-1 The liquid outlets are connected one by one. Among them, the liquid inlet end of the first-stage microfluidic bifurcation structure can be used as the liquid inlet end of the microreactor. N-1 The Nth-order microfluidic bifurcation structure has p N The liquid outlet can be used as the liquid outlet of the microreactor, that is, the microreactor has p N A liquid outlet.

[0068] The fluid flows into the microreactor through the liquid inlet end of the first-stage microfluidic bifurcation structure (i.e., the liquid inlet end of the microreactor), is divided into p parts by the first-stage microfluidic bifurcation structure, and is transmitted one by one to p second-stage microfluidic bifurcation structures, and is divided into p parts by the second-stage microfluidic bifurcation structure. 2 Then, they are transmitted one by one to p 2 In the third-level microfluidic bifurcation structure. N-2 The N-1th microfluidic bifurcation structure divides the fluid into p N-1 Then, they are transmitted one by one to p N-1 In the Nth-level microfluidic bifurcation structure, the fluid passes through p N-1The Nth-level microfluidic bifurcation structure is divided into p N parts, one-to-one corresponding to the p of the microreactor N Liquid flows out from the outlet.

[0069] It should be noted that the widths of the microfluidic bifurcated structures at different levels (including the widths of the bent pipe 2, the straight pipe 3, and the bifurcated pipe 4) are different, and the width of the microfluidic bifurcated structure at the upper level is greater than the width of the microfluidic bifurcated structure at the lower level. The lengths of the microfluidic bifurcated structures at different levels (including the lengths of the bent pipe 2, the straight pipe 3, and the bifurcated pipe 4) can be the same or different. The heights of the microfluidic bifurcated structures at different levels (including the heights of the bent pipe 2, the straight pipe 3, and the bifurcated pipe 4) are the same. The dimensions (including length, width, and height) of the auxiliary structures 5 in the microfluidic bifurcated structures at different levels can be the same or different. The dimensions of the microfluidic bifurcated structures at the same level (including the width, length, and height of the bent pipe 2, the straight pipe 3, and the bifurcated pipe 4) can be the same, and the dimensions (including length, width, and height) of the auxiliary structures 5 in the microfluidic bifurcated structures at the same level can be the same or different.

[0070] Each microfluidic bifurcation structure 1 in the microreactor may be provided with an auxiliary structure 5. For example, each microfluidic bifurcation structure 1 in an N-stage microfluidic bifurcation structure may be provided with an auxiliary structure 5, that is, m=N.

[0071] For example, combined with Figure 4 As shown, N=3, p=2, that is, the microreactor includes a three-stage microfluidic bifurcation structure, the bifurcated channel 4 in each microfluidic bifurcated structure 1 includes two parallel microchannels, and each microfluidic bifurcated structure 1 has two liquid outlets.

[0072] The number of the first-level microfluidic bifurcated structure 1a is one, and it has two liquid outlets. The number of the second-level microfluidic bifurcated structure 1b is two, and the two liquid inlet ends of the two second-level microfluidic bifurcated structures 1b are connected to the two liquid outlet ends of the first-level microfluidic bifurcated structure 1a in a one-to-one correspondence. The two second-level microfluidic bifurcated structures 1b have four liquid outlets. The number of the third-level microfluidic bifurcated structures 1c is four, and it has four liquid inlet ends. The liquid inlet ends of the four third-level microfluidic bifurcated structures 1c are connected to the four liquid outlet ends of the two second-level microfluidic bifurcated structures 1b in a one-to-one correspondence. The four third-level microfluidic bifurcated structures 1c have eight liquid outlets, which can be used as the liquid outlet ends of the microreactor. The liquid inlet end of the first-level microfluidic bifurcated structure 1a can be used as the liquid inlet end of the microreactor. The microreactor finally presents an 8-channel structure.

[0073] The fluid flows into the first-stage microfluidic bifurcated structure 1a through the liquid inlet of the microreactor, is divided into two parts by the first-stage microfluidic bifurcated structure 1a, and then is transmitted one by one to the two second-stage microfluidic bifurcated structures 1b. The fluid is divided into four parts by the second-stage microfluidic bifurcated structure 1b, and then is transmitted one by one to the four third-stage microfluidic bifurcated structures 1c. The fluid is divided into eight parts by the four third-stage microfluidic bifurcated structures 1c, and then flows out of the microreactor through the eight liquid outlets of the third-stage microfluidic bifurcated structure 1c (i.e., the liquid outlets of the microreactor).

[0074] In this embodiment, the widths of different levels of microfluidic bifurcations are different, and the lengths of different levels of microfluidic bifurcations can be the same or different. The widths w2 of the auxiliary structures 5 in different levels of microfluidic bifurcations can be different, and the widths w2 of the auxiliary structures 5 in the same level of microfluidic bifurcations can be the same. For example, in the first-level microfluidic bifurcation structure 1a, the width w1 of the straight channel 3 is 1000μm, the length x1 of the straight channel 3 is 800μm, the width w2 of the auxiliary structure 5 is 100μm, the length x2 of the auxiliary structure 5 is 400μm, and the height of the straight channel 3 and the auxiliary structure 5 are the same; in the second-level microfluidic bifurcation structure 1b, the width w1 of the straight channel 3 is 800μm, the length x1 of the straight channel 3 is 800μm, the width w2 of the auxiliary structure 5 is 80μm, the length x2 of the auxiliary structure 5 is 400μm, and the height of the straight channel 3 and the auxiliary structure 5 are the same; in the third-level microfluidic bifurcation structure 1c, the width w1 of the straight channel 3 is 600μm, the length x1 of the straight channel 3 is 600μm, the width w2 of the auxiliary structure 5 is 80μm, the length x2 of the auxiliary structure 5 is 300μm, and the straight channel 3 and the auxiliary structure 5 are the same height. The material used for the microfluidic bifurcation structure 1 and the auxiliary structure 5 may be PDMS.

[0075] When the fluid flow rate of the liquid inlet of the microreactor is set to 3m / s, the maximum flow deviation of the eight liquid outlets of the microreactor in the related art (the microfluidic bifurcated structure does not have an auxiliary structure) is about 13%. However, the microreactor in this embodiment is provided with an auxiliary structure 5 in each microfluidic bifurcated structure 1, and the maximum flow deviation of the eight liquid outlets is about 2%. Compared with the related art, this embodiment can reduce the deviation of the average distribution flow while ensuring a high flow rate of the fluid, thereby improving the fluid average distribution effect.

[0076] For another example, N=4, p=2, that is, the microreactor includes a four-stage microfluidic bifurcated structure, each bifurcated channel 4 includes two parallel microchannels, and each microfluidic bifurcated structure 1 has two liquid outlets.

[0077] The number of the first-level microfluidic bifurcated structure is one, and it has two liquid outlets. The number of the second-level microfluidic bifurcated structures is two, and the two liquid inlet ends of the two second-level microfluidic bifurcated structures are connected to the two liquid outlet ends of the first-level microfluidic bifurcated structure in one-to-one correspondence. The two second-level microfluidic bifurcated structures have four liquid outlets. The number of the third-level microfluidic bifurcated structures is four, and it has four liquid inlet ends. The liquid inlet ends of the four third-level microfluidic bifurcated structures are connected to the four liquid outlet ends of the two second-level microfluidic bifurcated structures in one-to-one correspondence. The four third-level microfluidic bifurcated structures have eight liquid outlets. The number of the fourth-level microfluidic bifurcated structures is eight, and it has sixteen liquid outlets. The eight liquid inlet ends of the eight fourth-level microfluidic bifurcated structures are connected to the eight liquid outlet ends of the four third-level microfluidic bifurcated structures in one-to-one correspondence. The eight fourth-level microfluidic bifurcated structures have sixteen liquid outlets, which can be used as the liquid outlet end of the microreactor. The liquid inlet end of the first-level microfluidic bifurcated structure can be used as the liquid inlet end of the microreactor. The microreactor finally presents a 16-channel structure.

[0078] The fluid flows into the first-level microfluidic bifurcation structure through the liquid inlet of the microreactor, is divided into two parts by the first-level microfluidic bifurcation structure, and then is transmitted to the two second-level microfluidic bifurcation structures one by one. The fluid is divided into four parts by the second-level microfluidic bifurcation structure, and then is transmitted to the four third-level microfluidic bifurcation structures one by one. The fluid is divided into eight parts by the four third-level microfluidic bifurcation structures, and then is transmitted to the eight fourth-level microfluidic bifurcation structures one by one. The fluid is divided into sixteen parts by the eight fourth-level microfluidic bifurcation structures, and then flows out of the microreactor through the sixteen liquid outlets of the eight fourth-level microfluidic bifurcation structures (i.e., the liquid outlets of the microreactor).

[0079] In this embodiment, the widths of microfluidic bifurcation structures at different levels are different, and the lengths of microfluidic bifurcation structures at different levels can be the same or different. The width w2 of the auxiliary structure 5 in microfluidic bifurcation structures at different levels can be different, and the width w2 of the auxiliary structure 5 in the microfluidic bifurcation structure at the same level can be the same. For example, in the first-level microfluidic bifurcation structure, the width w1 of the straight channel 3 is set to 1000μm, the length x1 of the straight channel 3 is set to 800μm, the width w2 of the auxiliary structure 5 is set to 100μm, the length x2 of the auxiliary structure 5 is set to 400μm, and the heights of the straight channel 3 and the auxiliary structure 5 are the same; in the second-level microfluidic bifurcation structure, the width w1 of the straight channel 3 is set to 800μm, the length x1 of the straight channel 3 is set to 800μm, the width w2 of the auxiliary structure 5 is set to 80μm, the length x2 of the auxiliary structure 5 is set to 400μm, and the heights of the straight channel 3 and the auxiliary structure 5 are the same. In the third-level microfluidic bifurcation structure, the width w1 of the straight channel 3 is set to 600 μm, the length x1 of the straight channel 3 is set to 600 μm, the width w2 of the auxiliary structure 5 is set to 80 μm, the length x2 of the auxiliary structure 5 is set to 600 μm, and the height of the straight channel 3 and the auxiliary structure 5 is the same; in the fourth-level microfluidic bifurcation structure, the width w1 of the straight channel 3 is set to 400 μm, the length x1 of the straight channel 3 is set to 400 μm, the width w2 of the auxiliary structure 5 is set to 60 μm, the length x2 of the auxiliary structure 5 is set to 400 μm, and the height of the straight channel 3 and the auxiliary structure 5 is the same. The material used for the microfluidic bifurcation structure 1 and the auxiliary structure 5 can be PDMS.

[0080] When the fluid flow rate of the liquid inlet of the microreactor is set to 3m / s, the maximum flow deviation of the 16 liquid outlets of the microreactor in the related art (the microfluidic bifurcated structure does not have an auxiliary structure) is about 16%. However, the microreactor in this embodiment is provided with an auxiliary structure 5 in each microfluidic bifurcated structure 1, and the maximum flow deviation of its 16 liquid outlets is about 2%. Compared with the related art, this embodiment can reduce the deviation of the average distribution flow while ensuring a high flow rate of the fluid, thereby improving the fluid average distribution effect.

[0081] The microreactor may be provided with auxiliary structures 5 in part of the microfluidic bifurcating structure 1. For example, in an N-stage microfluidic bifurcating structure, the auxiliary structures 5 may be provided for the first m-stage microfluidic bifurcating structures, where m<N.

[0082] For example, combined with Figure 5As shown, N=3, p=2, m=2, that is, the microreactor includes a three-stage microfluidic bifurcation structure, the bifurcated channel 4 in each microfluidic bifurcation structure 1 includes two parallel microchannels, and each microfluidic bifurcation structure 1 has two liquid outlets. An auxiliary structure 5 is provided in the first two microfluidic bifurcation structures (i.e., the first microfluidic bifurcation structure 1a and the two second microfluidic bifurcation structures 1b).

[0083] The number of auxiliary structures 5 and the position of the microfluidic bifurcation structure 1 where the auxiliary structures 5 are set are set according to the actual requirements for the fluid equal distribution effect. For example, the higher the requirements for fluid equal distribution (such as the smaller the deviation of the equal distribution flow rate), the more auxiliary structures 5 need to be set. If the fluid equal distribution effect achieved after the auxiliary structures 5 are set in the first few microfluidic bifurcation structures of the microreactor can meet the actual requirements (such as the deviation of the equal distribution flow rate is less than the target deviation value), there is no need to continue to set the auxiliary structures 5 in the remaining microfluidic bifurcation structures 1; if the actual requirements for the fluid equal distribution effect are higher (such as the target deviation value is smaller), the auxiliary structures 5 can be set in each level of the microfluidic equal distribution structure of the microreactor.

[0084] In summary, in the microfluidic bifurcation structure 1 of the microreactor, by setting the auxiliary structure 5 at intervals along the width direction W in the straight pipe 3, when the fluid enters the straight pipe 3 through the bent pipe 2, it can effectively limit the fluid from deviating toward the outside of the bent pipe 2 (that is, toward the straight pipe 3 away from the width direction W of the bent pipe 2), thereby improving the fluid balancing effect, thereby improving the consistency of the retention time of the fluid in the parallel microchannels, and further improving the reaction effect of the microreactor. The auxiliary structure 5 is set in the microfluidic bifurcation structure 1, does not change the structure of the microfluidic bifurcation structure 1 itself, and does not destroy the functionality of the microfluidic bifurcation structure 1 itself, can be applied to different microreactors, and has good versatility. When the microreactor has a multi-stage microfluidic bifurcation structure, the auxiliary structure 5 can be selectively set in all or part of the microfluidic bifurcation structures at each level according to the actual needs for the fluid balancing effect to meet different reaction requirements.

[0085] Accordingly, the present application also provides a method for manufacturing a microreactor, which can manufacture the microreactor in the above embodiment, comprising:

[0086] providing a substrate;

[0087] forming a microfluidic bifurcation groove and an auxiliary structure on a substrate, wherein the auxiliary structure is located in the microfluidic bifurcation groove;

[0088] The formed microfluidic bifurcation groove is covered with a cover plate to form a microfluidic bifurcation structure.

[0089] Combination Figure 1As shown, the microfluidic bifurcated structure 1 includes a bent pipe 2, a straight pipe 3 and a bifurcated pipe 4 located in the same plane, the liquid outlet end of the bent pipe 2 is connected to the liquid inlet end of the straight pipe 3, and the liquid outlet end of the straight pipe 3 is connected to the liquid inlet end of the bifurcated pipe 4. The auxiliary structure 5 is arranged in the straight pipe 3 along the width direction W of the straight pipe 3, and extends along the axial direction X and the height direction H of the straight pipe 3, the height direction H is perpendicular to the plane, and the width direction W is perpendicular to the axial direction X and parallel to the plane.

[0090] In some embodiments, the step of forming a microfluidic bifurcation groove and an auxiliary structure on a substrate includes: using an etching process to etch a provided substrate to form the microfluidic bifurcation groove and the auxiliary structure on the substrate.

[0091] The microfluidic bifurcation groove and the auxiliary structure 5 are etched on the substrate by an etching process. The microfluidic bifurcation groove includes the groove of the curved pipe 2, the groove of the straight pipe 3 and the groove of the bifurcated pipe 4, and is located in the same plane (such as a horizontal plane). The liquid outlet end of the groove of the curved pipe 2 is connected to the liquid inlet end of the groove of the straight pipe 3, and the liquid outlet end of the groove of the straight pipe 3 is connected to the liquid inlet end of the groove of the bifurcated pipe 4. The substrate material can be silicon or glass, etc. The material of the bottom and side wall of the microfluidic bifurcation groove is the material of the substrate.

[0092] The auxiliary structure 5 is formed integrally with the microfluidic bifurcation groove, and the material of the auxiliary structure 5 is the same as that of the bottom and sidewall of the microfluidic bifurcation groove.

[0093] After forming the microfluidic bifurcation groove and the auxiliary structure 5, the cover plate is fitted and pressed against the microfluidic bifurcation groove to obtain a microfluidic bifurcation structure 1 with a closed pipeline structure. The cover plate can be a glass sheet. The top material of the microfluidic bifurcation structure 1 is the material of the cover plate.

[0094] In some embodiments, the step of forming the microfluidic bifurcation groove and the auxiliary structure on the substrate includes: forming a photoresist layer on the substrate; and forming the microfluidic bifurcation groove and the auxiliary structure in the photoresist layer.

[0095] A photoresist layer is spin-coated on a provided substrate, and the substrate with the spin-coated photoresist layer is baked on a hot stage, and then cooled to room temperature. The thickness of the photoresist layer can be 100 μm. The temperature of the hot stage can be set to 95° C., and the baking time can be set to 20 minutes. The material of the photoresist layer can include SU-8 photoresist. The substrate material can include silicon, glass, photoresist (such as SU-8 photoresist), etc.

[0096] The exposure process is adopted to expose the substrate of the spin-coated photoresist layer by ultraviolet light using an optical mask layer to obtain a sample. After exposure, the sample is post-baked and cooled to room temperature. The sample is placed in a developer for development, and the sample is rinsed and then blown dry to form a microfluidic bifurcation groove and an auxiliary structure 5 on the substrate. The exposure can be performed using i-line, and the exposure dose can be set to 250mJ / cm 2 . The temperature of the hot plate for post-baking can be set to 95°C, and the time can be set to 10 minutes. The developer can be selected according to the photoresist type and processing technology, for example, it can be a SU-8 photoresist developer corresponding to SU-8 photoresist. The developing time can be set to 10 minutes. The rinsing solution can be isopropanol, and the rinsing time can be set to 20 seconds. Nitrogen can be used for drying. The material at the bottom of the microfluidic bifurcation groove is the material of the substrate, and the material of the side wall and the auxiliary structure 5 can be SU-8 photoresist.

[0097] After forming the microfluidic bifurcation groove and the auxiliary structure 5, a photoresist layer (such as SU-8 photoresist) is spin-coated on the cover plate and baked on a hot stage. The thickness of the photoresist layer on the cover plate can be set to 20 μm. The temperature of the hot stage can be set to 95° C., and the baking time can be set to 20 minutes.

[0098] The microfluidic bifurcation groove is fitted and pressed with the cover plate, and UV exposure is performed through the substrate, and then post-baked and cooled to room temperature to form a microfluidic bifurcation structure 1 with a closed pipeline structure. The exposure can be set to i line, and the exposure dose can be set to 60mJ / cm 2 The post-baking hot plate temperature can be set to 95° C., and the post-baking time can be set to 10 minutes. The top material of the microfluidic bifurcated structure 1 is the material of the cover plate, such as glass.

[0099] In some embodiments, the step of forming a microfluidic bifurcation groove and an auxiliary structure on a substrate includes: setting a template on the substrate; and forming the microfluidic bifurcation groove and the auxiliary structure on the substrate by the template.

[0100] The template is prepared as follows:

[0101] A photoresist layer is spin-coated on a substrate, and the substrate on which the photoresist layer is spin-coated is baked on a hot stage and cooled to room temperature. The thickness of the photoresist layer can be 100 μm. The temperature of the hot stage can be set to 95° C., and the baking time can be set to 20 minutes. The material of the photoresist layer can include SU-8 photoresist. The substrate material can include silicon, glass, and photoresist (such as SU-8 photoresist).

[0102] Then, an exposure process is used to expose the substrate of the spin-coated photoresist layer to ultraviolet light using an optical mask layer to obtain a sample. After exposure, the sample is post-baked and cooled to room temperature. The sample is placed in a developer for development, rinsed after development, and then blown dry to form a template on the substrate. Exposure can be performed using i-line, and the exposure dose can be set to 250mJ / cm 2 The post-baking hot plate temperature can be set to 95°C, and the time can be set to 10 minutes. The developer is selected according to the photoresist type and processing technology, and can be SU-8 photoresist developer, and the development time can be set to 10 minutes. The rinse solution can be isopropanol, and the rinse time can be set to 20 seconds. Nitrogen can be used for drying.

[0103] After making the template, the PDMS solution is injected into the template on the substrate to replicate the structure. The static template and the PDMS solution are placed in an oven for curing, and then cooled to room temperature to obtain a microfluidic bifurcation groove and an auxiliary structure 5. The curing oven temperature can be set to 50°C, and the curing time can be set to 24 hours. The PDMS solution can be prepared by mixing a PDMS prepolymer and a curing agent. The mixing ratio of the PDMS prepolymer and the curing agent is set to 10:1. The PDMS prepolymer may include a silicon polymer, and the curing agent may include an organic peroxide, an amine compound, and the like. The mixed PDMS solution can be placed in a vacuum box to remove bubbles until the bubbles completely disappear, thereby obtaining the desired PDMS solution. The side walls of the microfluidic bifurcation groove are made of the same material as the auxiliary structure 5, such as PDMS.

[0104] The prepared microfluidic bifurcation groove, auxiliary structure 5 and cover plate are subjected to surface activation treatment by a reactive ion etcher. The gas for surface activation treatment can be set to oxygen, the gas flow rate can be set to 20 SCCM (standard cubic centimeters per minute), the power can be set to 20 W, and the treatment time can be set to 1 minute. The microfluidic bifurcation groove and cover plate that have undergone surface activation treatment are fitted and pressed, placed in an oven for baking, and then naturally cooled to room temperature to form a microfluidic bifurcation structure 1 with a closed pipeline structure. The top material of the microfluidic bifurcation structure 1 is the material of the cover plate, a glass sheet.

[0105] In this embodiment, a microreactor is manufactured by using a template, which can replicate the structure and improve production efficiency. Different materials can also be used to manufacture the pipeline sidewalls of the microfluidic bifurcation structure 1 to meet different application requirements.

[0106] In some embodiments, in combination Figure 1 As shown, the auxiliary structure 5 is located between a first center position and a first position in the width direction W of the straight pipe 3 , and the first position is offset by a first distance in the width direction W away from the curved pipe 2 compared to the first center position.

[0107] In some embodiments, in combination Figure 3 The first distance shown is no greater than 10% of the width w1 of the straight pipe 3 .

[0108] In some embodiments, the width w2 of the auxiliary structure 5 is 10%-20% of the width w1 of the linear pipe 3 .

[0109] In some embodiments, the auxiliary structure 5 is located between a second position and a third position of the axial direction X of the straight pipe 3, the second position is offset by a second distance from the second center position toward the axial direction X close to the curved pipe 2, and the third position is offset by a third distance from the second center position toward the axial direction X close to the forked pipe 4, and the second center position is the center position of the axial direction X of the straight pipe 3.

[0110] In some embodiments, the second distance and the third distance are respectively no greater than 10% of the length x1 of the linear pipe 3 along the axial direction X.

[0111] In some embodiments, the length x2 of the auxiliary structure 5 along the axial direction X is 40%-70% of the length x1 of the straight pipe 3 along the axial direction X.

[0112] In some embodiments, in combination Figure 2 As shown, the auxiliary structure 5 is located between the fourth position and the fifth position in the height direction H of the straight pipe 3, the fourth position is offset upward by a fourth distance compared to the third center position, and the fifth position is offset downward by a fifth distance compared to the third center position, and the third center position is the center position in the height direction H of the straight pipe 3.

[0113] In some embodiments, the fourth distance and the fifth distance are each no greater than 10% of the height h1 of the linear pipe 3 .

[0114] In some embodiments, the height h2 of the auxiliary structure 5 is 50%-100% of the height h1 of the linear pipe 3 .

[0115] In some embodiments, the orthographic projection of the auxiliary structure 5 along the height direction H is rectangular, elliptical or rhombus-shaped.

[0116] In some embodiments, the material of the auxiliary structure 5 includes glass, photoresist, silicon or PDMS.

[0117] In some embodiments, the microreactor includes a plurality of microfluidic bifurcated structures 1, the plurality of microfluidic bifurcated structures 1 constitute N-level microfluidic bifurcated structures, N ≥ 2, the liquid outlet end of the bifurcated pipe 4 of the upper-level microfluidic bifurcated structure is connected to the liquid inlet end of the bent pipe 2 of the lower-level microfluidic bifurcated structure;

[0118] An auxiliary structure 5 is provided in the first m levels of microfluidic bifurcation structures, m≤N.

[0119] In summary, according to a microreactor provided by an embodiment of the present application, by setting an auxiliary structure 5 at intervals along the width direction W in the straight pipe 3, when the fluid enters the straight pipe 3 through the bent pipe 2, the fluid is effectively restricted from deviating toward the outside of the bent pipe 2 (i.e., toward the straight pipe 3 away from the width direction W of the bent pipe 2), thereby improving the fluid balancing effect, thereby improving the consistency of the retention time of the fluid in the parallel microchannels, and thus improving the reaction effect of the microreactor. When the microreactor has a multi-stage microfluidic bifurcation structure, the auxiliary structure 5 can be selectively set in each stage of the microfluidic bifurcation structure of the microreactor according to the actual demand for the fluid balancing effect, and has good applicability. The auxiliary structure 5 is set in the microfluidic bifurcation structure 1, does not change the structure of the microfluidic bifurcation structure 1 itself, and does not destroy the functionality of the microfluidic bifurcation structure 1 itself, and can be applied to different microreactors, with good versatility. The auxiliary structure 5 is integrally formed with the microfluidic bifurcation groove, which can simplify the process complexity.

[0120] The terms "first", "second", etc. in the specification and claims of this application are used to distinguish similar objects, and are not used to describe a specific order or sequence. It should be understood that the terms used in this way can be interchangeable under appropriate circumstances, so that the embodiments of the present application can be implemented in an order other than those illustrated or described herein, and the objects distinguished by "first", "second", etc. are generally of the same type, and the number of objects is not limited. For example, the first object can be one or more.

[0121] In the description of the present application, “plurality” means two or more.

[0122] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0123] Although the embodiments of the present application have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present application, and that the scope of the present application is defined by the claims and their equivalents.

Claims

1. A microreactor, characterized in that: include: A microfluidic bifurcated structure, comprising a bent pipe, a straight pipe and a bifurcated pipe located in the same plane, wherein the bent pipe is located on one side of the straight pipe along the width direction, the liquid outlet end of the bent pipe is connected to the liquid inlet end of the straight pipe, and the liquid outlet end of the straight pipe is connected to the liquid inlet end of the bifurcated pipe; the bifurcated pipe comprises a plurality of parallel micro-pipes; Auxiliary structures are arranged in the linear pipeline at intervals along the width direction of the linear pipeline, and extend along the axial direction and height direction of the linear pipeline, do not exceed the two ends of the linear pipeline along the axial direction, and the length of the auxiliary structure along the axial direction is less than the length of the linear pipeline along the axial direction, the height direction is perpendicular to the plane, and the width direction is perpendicular to the axial direction and parallel to the plane; the auxiliary structure is used to evenly distribute the fluid in the linear pipeline to the multiple parallel micro-pipes.

2. The microreactor according to claim 1, characterized in that The auxiliary structure is located between a first center position and a first position in the width direction of the straight pipe, and the first position is offset by a first distance in the width direction away from the curved pipe compared to the first center position.

3. The microreactor according to claim 2, characterized in that: The first distance is no greater than 10% of the width of the linear pipe.

4. The microreactor according to claim 1, characterized in that: The width of the auxiliary structure is 10%-20% of the width of the linear pipe.

5. The microreactor according to claim 1, characterized in that: The auxiliary structure is located between the second position and the third position in the axial direction of the straight pipe, the second position is offset by a second distance in the axial direction toward the curved pipe compared to the second center position, and the third position is offset by a third distance in the axial direction toward the bifurcated pipe compared to the second center position, and the second center position is the axial center position of the straight pipe.

6. The microreactor according to claim 5, characterized in that: The second distance and the third distance are respectively no greater than 10% of the length of the linear pipe along the axial direction.

7. The microreactor according to claim 1, characterized in that: The length of the auxiliary structure along the axial direction is 40%-70% of the length of the straight pipe along the axial direction.

8. The microreactor according to claim 1, characterized in that: The auxiliary structure is located between a fourth position and a fifth position in the height direction of the linear pipe, the fourth position is offset upward by a fourth distance compared to the third center position, and the fifth position is offset downward by a fifth distance compared to the third center position, and the third center position is the center position of the linear pipe in the height direction.

9. The microreactor according to claim 8, characterized in that The fourth distance and the fifth distance are respectively no greater than 10% of the height of the linear pipe.

10. The microreactor according to claim 1, characterized in that: The height of the auxiliary structure is 50%-100% of the height of the linear pipeline.

11. The microreactor according to claim 1, characterized in that: The orthographic projection of the auxiliary structure along the height direction is rectangular, elliptical or rhombus-shaped; The material of the auxiliary structure includes glass, photoresist, silicon or PDMS.

12. The microreactor according to any one of claims 1 to 11, characterized in that: The microreactor comprises a plurality of the microfluidic bifurcation structures, wherein the plurality of microfluidic bifurcation structures constitute N-level microfluidic bifurcation structures, N≥2, and the liquid outlet end of the bifurcation pipeline of the upper-level microfluidic bifurcation structure is connected to the liquid inlet end of the bent pipeline of the lower-level microfluidic bifurcation structure; The auxiliary structure is provided in the first m levels of microfluidic bifurcation structures, m≤N.

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