Feed for pigs in different growth stages

Abstract

The invention relates to the technical field of livestock feed, in particular to feed for pigs in different growth stages. The invention provides a feed for different growth stages of pigs, which comprises a pig feed for a piglet stage and a pig feed for an adult piglet stage, and the pig feed for the piglet stage is prepared from wheat, cottonseed meal, soybean meal and fish meal with the crushed particle size of 400-420 [mu] m, the feed is composed of soybean meal exosomes, cottonseed meal exosomes, non-starch polysaccharide enzyme, protease, amino acids, probiotics and a premix. The pig feed for the adult pig stage is prepared from wheat, cottonseed meal, degossypolized cottonseed protein and mountain flour with the crushing particle size of 600-650 microns, as well as wheat exosome, cottonseed meal exosome, non-starch polysaccharide enzyme, protease, amino acid, probiotics and premix. According to the characteristics of pigs in different growth stages, the healthy growth of the pigs is promoted by optimizing the raw material ratio, adjusting the crushing granularity and adding specific functional components, and the breeding benefits are improved.

Description

Technical Field

[0001] The invention relates to the technical field of animal husbandry feed, and in particular to feed for pigs at different growth stages. Background Art

[0002] With the development of large-scale and intensive breeding industry in my country, the demand for feed resources has been in short supply, or even seriously insufficient. Wheat, corn, bran, soybean meal, cottonseed meal, rapeseed meal, beet meal, meat and bone meal, etc. have always been the commonly used basic energy protein raw material feed sources. However, the direct application of these feeds often has problems such as low digestibility and nutritional imbalance, which affects the growth performance and health status of pigs.

[0003] Because the digestive system of piglets is relatively weak, the digestion capacity of feed is limited; and the quality of piglets and the speed of growth are directly related to the time and amount of meat produced by pigs. Therefore, many breeders use concentrate or concentrated feed to feed piglets. Although this method can ensure the growth of piglets and save labor, because piglets are small and their organs are in the development stage, only feeding concentrate or concentrated feed cannot meet the needs of piglets. The shortage of trace elements will also slow down the growth of piglets. Due to unreasonable nutrition matching, many concentrates or concentrated feeds are not completely digested and excreted with feces, which not only causes feed waste and increases feeding costs, but also may affect the immunity of piglets, causing adverse consequences and prolonging the time to market. As pigs grow, their digestive system gradually develops and improves their digestion capacity for feed. This stage is very critical for pig farming enterprises. Enterprises should adjust the feed ingredients of pigs in real time so that pigs can not only better ingest various nutrients they need, but also better prevent pigs from being attacked by diseases at this stage and improve their immunity.

[0004] Therefore, in the modern pig farming industry, with the rapid development of scale and intensive production, how to scientifically and rationally formulate pig feed to meet the nutritional needs of pigs at different growth stages has become the key to improving breeding efficiency and promoting the healthy growth of pigs. Traditional feed formulas often ignore the physiological changes of pigs during growth and the differences in their nutritional needs, resulting in low feed utilization efficiency and even affecting the growth performance and health of pigs. Especially in the piglet stage and the adult pig stage, due to the significant differences in physiological characteristics, digestive capacity and nutritional needs, it is particularly important to develop feed formulas specifically for these two stages. Summary of the invention

[0005] In view of this, the object of the present invention is to determine the components and content of feed according to the digestion capacity of piglets and adult pigs and the demand for feed utilization, so as to develop a feed for different growth stages of pigs, comprising pig feed for the piglet stage and pig feed for the adult piglet stage.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] In a first aspect, the present invention provides a feed for pigs at different growth stages, the feed comprising pig feed for piglets and pig feed for adult piglets, wherein:

[0008] The pig feed for piglets is composed of wheat with a crushing particle size of 400-420 μm, cottonseed meal with a crushing particle size of 400-420 μm, soybean meal with a crushing particle size of 400-420 μm, fish meal with a crushing particle size of 400-420 μm, soybean meal exosomes, cottonseed meal exosomes, non-starch polysaccharide enzymes, proteases, amino acids, probiotics and premixes;

[0009] The pig feed for adult pigs consists of wheat with a crushing particle size of 600-650 μm, cottonseed meal with a crushing particle size of 600-650 μm, dephenolized cottonseed protein with a crushing particle size of 600-650 μm, stone powder with a crushing particle size of 600-650 μm, wheat exosomes, cottonseed meal exosomes, non-starch polysaccharide enzymes, proteases, amino acids, probiotics and premixes.

[0010] Preferably, in parts by weight,

[0011] The pig feed for the piglet stage consists of 200-220 parts of wheat with a crushed particle size of 400-420 μm, 200-220 parts of cottonseed meal with a crushed particle size of 400-420 μm, 40-45 parts of soybean meal with a crushed particle size of 400-420 μm, 20-25 parts of fish meal with a crushed particle size of 400-420 μm, 5-8 parts of soybean meal exosomes, 5-8 parts of cottonseed meal exosomes, 0.5-1 part of non-starch polysaccharide enzyme, 0.5-1 part of protease, 5-7 parts of amino acids, 3-6 parts of probiotics and 0.3-0.5 parts of premix.

[0012] More preferably, in parts by weight,

[0013] The non-starch polysaccharide enzyme consists of cellulase and xylanase in a weight ratio of 3:2;

[0014] The protease is composed of pepsin and cathepsin in a weight ratio of 0.5:1;

[0015] The amino acids consist of lysine, methionine, tryptophan and phenylalanine;

[0016] The probiotics consist of Lactococcus lactis, Bacillus licheniformis and Saccharomyces cerevisiae;

[0017] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0018] Further preferably, in parts by weight,

[0019] The pig feed for the piglet stage consists of 200 parts of wheat with a crushed particle size of 400 μm, 220 parts of cottonseed meal with a crushed particle size of 400 μm, 40 parts of soybean meal with a crushed particle size of 400 μm, 22 parts of fish meal with a crushed particle size of 400 μm, 6 parts of soybean meal exosomes, 6 parts of cottonseed meal exosomes, 0.5 parts of non-starch polysaccharide enzyme, 0.5 parts of protease, 6 parts of amino acids, 5 parts of probiotics and 0.5 parts of premix.

[0020] Preferably, in parts by weight,

[0021] The pig feed for adult pigs consists of 180-200 parts of wheat with a crushing particle size of 600-650 μm, 180-200 parts of cottonseed meal with a crushing particle size of 600-650 μm, 35-40 parts of dephenolized cottonseed protein with a crushing particle size of 600-650 μm, 20-22 parts of stone powder with a crushing particle size of 600-650 μm, 8-10 parts of wheat exosomes, 7-10 parts of cottonseed meal exosomes, 0.8-1.2 parts of non-starch polysaccharide enzyme, 0.8-1.2 parts of protease, 5-6 parts of amino acids, 3-5 parts of probiotics and 0.3-0.5 parts of premix.

[0022] More preferably, in parts by weight,

[0023] The non-starch polysaccharide enzyme is composed of glucanase and pectinase in a weight ratio of 2:1;

[0024] The protease consists of trypsin and papain in a weight ratio of 1:1;

[0025] The amino acids consist of threonine, valine, leucine and isoleucine;

[0026] The probiotics consist of Lactobacillus plantarum, Bacillus subtilis and Saccharomyces cerevisiae;

[0027] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0028] Further preferably, in parts by weight,

[0029] The pig feed for adult pigs consists of 180 parts of wheat with a crushed particle size of 600 μm, 200 parts of cottonseed meal with a crushed particle size of 600 μm, 40 parts of dephenolized cottonseed protein with a crushed particle size of 600 μm, 22 parts of stone powder with a crushed particle size of 600 μm, 8 parts of wheat exosomes, 7 parts of cottonseed meal exosomes, 0.8 parts of non-starch polysaccharide enzyme, 0.8 parts of protease, 5 parts of amino acids, 3 parts of probiotics and 0.4 parts of premix.

[0030] In a second aspect, the invention provides application of the feed of the present invention in feeding piglets.

[0031] In a third aspect, the invention provides application of the feed of the present invention in feeding adult pigs.

[0032] In a fourth aspect, there is provided application of the feed of the present invention in improving pig immunity and / or improving pig growth performance.

[0033] A fifth aspect provides application of the feed of the present invention in feeding pigs at different growth stages.

[0034] Compared with the prior art, the beneficial effects of the present invention are:

[0035] The present invention proposes a new feed formula based on the characteristics of pigs at different growth stages. By optimizing the raw material ratio, adjusting the crushing particle size and adding specific functional ingredients (such as exosomes, enzyme preparations, amino acids, and probiotics), the feed's palatability, digestibility, and nutrient absorption efficiency are improved, thereby promoting the healthy growth of pigs and improving breeding benefits. The specific technical effects are as follows:

[0036] Improving immunity:

[0037] Enhance immunity: On the one hand, the addition of probiotics can regulate the balance of pig intestinal flora, enhance immunity and reduce the occurrence of diseases. On the other hand, the addition of exosomes can enhance the immunity of animals and improve their resistance to diseases, which is of great significance for improving the health level and production performance of animals.

[0038] Improved growth performance:

[0039] Improve feed utilization: On the one hand, by finely controlling the particle size of the raw materials, the feed particle size is more suitable for the chewing and digestion ability of pigs at different stages, reducing feed waste. On the other hand, by adding different exosomes at different growth stages of pigs (specifically, adding soybean meal exosomes and cottonseed meal exosomes in the piglet stage, and adding wheat exosomes and cottonseed meal exosomes in the adult pig stage), exosomes are more likely to pass through the intestinal barrier due to their tiny size and specific surface properties, and be absorbed and utilized by the body. Exosomes can carry specific signal molecules that bind to receptors in the animal's body, thereby playing a more precise and efficient regulatory role. This targeted effect helps reduce nutrient waste and improve feed utilization.

[0040] Promote digestion and absorption: Adding different non-starch polysaccharide enzymes and proteases at different stages of pigs can help improve the digestion and absorption rate of nutrients. Specifically, adding non-starch polysaccharide enzymes composed of cellulase and xylanase in a weight ratio of 3:2 and proteases composed of pepsin and cathepsin in a weight ratio of 0.5:1 in the piglet stage can help improve the digestion and absorption rate of nutrients in piglets. Adding non-starch polysaccharide enzymes composed of glucanase and pectinase in a weight ratio of 2:1 and proteases composed of trypsin and papain in a weight ratio of 1:1 in the adult pig stage can help break down complex carbohydrates and proteins in feed, thereby improving the digestion and absorption rate of nutrients in adult pigs.

[0041] Promote growth: On the one hand, reasonable amino acid ratio and comprehensive nutritional support can help pigs grow quickly, improve slaughter weight and carcass quality. On the other hand, growth factors and other growth-promoting substances carried in exosomes can stimulate the growth and development of animals and improve feed conversion efficiency.

[0042] Detoxification effect: If the raw materials contain ingredients that are harmful to animals (such as free cottonpol, etc.), the intake of these harmful substances can be reduced to a certain extent by extracting exosomes; because exosomes mainly carry bioactive molecules that are beneficial to animals, while harmful substances remain in the raw material residues. DETAILED DESCRIPTION

[0043] The present invention will be described in detail below in conjunction with specific implementations and examples, and the advantages and various effects of the present invention will be more clearly presented. It should be understood by those skilled in the art that these specific implementations and examples are used to illustrate the present invention, rather than to limit the present invention.

[0044] In an embodiment of the present invention, the method for preparing soybean meal exosomes is as follows:

[0045] ① Add 300 mL of sterilized PBS to 230 g of fresh soybean meal and crush it with a crusher until a uniform slurry is formed; centrifuge the crushed slurry at 5°C, 3000×g for 40 min to remove larger residues and impurities, and take the yellow transparent solution in the middle layer;

[0046] ② Centrifuge the yellow transparent solution obtained in step ① at 5°C, 10,000×g for 60 min, and take the supernatant;

[0047] ③ The supernatant obtained in step ② was centrifuged at 5°C, 120,000×g for 60 min, and then the precipitate was resuspended in 3 mL of sterile PBS and centrifuged at 5°C, 150,000×g for 65 min, and the precipitate was resuspended in 3 mL of sterile PBS again to obtain soybean meal exosomes.

[0048] In an embodiment of the present invention, the method for preparing cottonseed meal exosomes is as follows:

[0049] ① Add 260 mL of sterilized PBS to 200 g of fresh cottonseed meal and crush it with a crusher until a uniform slurry is formed; centrifuge the crushed slurry at 5°C, 3000×g for 35 min to remove larger residues and impurities, and take the yellow or light yellow transparent solution in the middle layer;

[0050] ② Centrifuge the yellow or light yellow transparent solution obtained in step ① at 5°C, 10,000×g for 55 min, and take the supernatant;

[0051] ③ The supernatant obtained in step ② was centrifuged at 5°C, 120,000×g for 55 min, and then the precipitate was resuspended in 3 mL of sterile PBS and centrifuged at 5°C, 150,000×g for 65 min, and the precipitate was resuspended in 3 mL of sterile PBS again to obtain cottonseed meal exosomes.

[0052] In an embodiment of the present invention, the preparation method of wheat exosomes is as follows:

[0053] ① Add 350 mL of sterilized PBS to 280 g of fresh wheat and crush it with a crusher until a uniform slurry is formed; centrifuge the crushed slurry at 5°C, 3000×g for 45 min to remove larger residues and impurities, and take the supernatant or the transparent solution in the middle layer;

[0054] ② Centrifuge the supernatant or the transparent solution of the middle layer obtained in step ① at 5°C, 10,000×g for 65 min, and take the supernatant;

[0055] ③ The supernatant obtained in step ② was centrifuged at 5°C, 120,000×g for 65 min, and then the precipitate was resuspended in 3 mL of sterile PBS and centrifuged at 5°C, 150,000×g for 70 min, and the precipitate was resuspended in 3 mL of sterile PBS again to obtain wheat exosomes.

[0056] Example 1

[0057] This embodiment provides a feed for pigs at different growth stages, the feed comprising pig feed for piglets and pig feed for adult piglets, calculated by weight:

[0058] The pig feed for piglets is composed of 200 parts of wheat with a crushing particle size of 400 μm, 200 parts of cottonseed meal with a crushing particle size of 400 μm, 40 parts of soybean meal with a crushing particle size of 400 μm, 20 parts of fish meal with a crushing particle size of 400 μm, 5 parts of soybean meal exosomes, 5 parts of cottonseed meal exosomes, 0.5 parts of non-starch polysaccharide enzyme, 0.5 parts of protease, 5 parts of amino acids, 3 parts of probiotics and 0.3 parts of premix; wherein,

[0059] The non-starch polysaccharide enzymes consist of cellulase and xylanase in a weight ratio of 3:2;

[0060] The protease consists of pepsin and cathepsin in a weight ratio of 0.5:1;

[0061] The amino acids consist of lysine, methionine, tryptophan, and phenylalanine;

[0062] The probiotics consisted of Lactococcus lactis, Bacillus licheniformis, and Saccharomyces cerevisiae;

[0063] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0064] The pig feed for adult pigs is composed of 180 parts of wheat with a crushing particle size of 600 μm, 180 parts of cottonseed meal with a crushing particle size of 600 μm, 35 parts of dephenolized cottonseed protein with a crushing particle size of 600 μm, 20 parts of stone powder with a crushing particle size of 600 μm, 8 parts of wheat exosomes, 7 parts of cottonseed meal exosomes, 0.8 parts of non-starch polysaccharide enzyme, 0.8 parts of protease, 5 parts of amino acids, 3 parts of probiotics and 0.3 parts of premix; wherein,

[0065] The non-starch polysaccharide enzyme consists of glucanase and pectinase in a weight ratio of 2:1;

[0066] The protease consisted of trypsin and papain in a weight ratio of 1:1;

[0067] The amino acids consist of threonine, valine, leucine, and isoleucine;

[0068] The probiotics consisted of Lactobacillus plantarum, Bacillus subtilis, and Saccharomyces cerevisiae;

[0069] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0070] Example 2

[0071] This embodiment provides a feed for pigs at different growth stages, the feed comprising pig feed for piglets and pig feed for adult piglets, calculated by weight:

[0072] The pig feed for piglets is composed of 220 parts of wheat with a crushed particle size of 400 μm, 220 parts of cottonseed meal with a crushed particle size of 400 μm, 45 parts of soybean meal with a crushed particle size of 400 μm, 25 parts of fish meal with a crushed particle size of 400 μm, 8 parts of soybean meal exosomes, 8 parts of cottonseed meal exosomes, 1 part of non-starch polysaccharide enzyme, 1 part of protease, 7 parts of amino acids, 6 parts of probiotics and 0.5 parts of premix; wherein,

[0073] The non-starch polysaccharide enzymes consist of cellulase and xylanase in a weight ratio of 3:2;

[0074] The protease consists of pepsin and cathepsin in a weight ratio of 0.5:1;

[0075] The amino acids consist of lysine, methionine, tryptophan, and phenylalanine;

[0076] The probiotics consisted of Lactococcus lactis, Bacillus licheniformis, and Saccharomyces cerevisiae;

[0077] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0078] The pig feed for adult pigs is composed of 200 parts of wheat with a crushing particle size of 600 μm, 200 parts of cottonseed meal with a crushing particle size of 600 μm, 40 parts of dephenolized cottonseed protein with a crushing particle size of 600 μm, 22 parts of stone powder with a crushing particle size of 600 μm, 10 parts of wheat exosomes, 10 parts of cottonseed meal exosomes, 1.2 parts of non-starch polysaccharide enzymes, 1.2 parts of proteases, 6 parts of amino acids, 5 parts of probiotics and 0.5 parts of premix; wherein,

[0079] The non-starch polysaccharide enzyme consists of glucanase and pectinase in a weight ratio of 2:1;

[0080] The protease consisted of trypsin and papain in a weight ratio of 1:1;

[0081] The amino acids consist of threonine, valine, leucine, and isoleucine;

[0082] The probiotics consisted of Lactobacillus plantarum, Bacillus subtilis, and Saccharomyces cerevisiae;

[0083] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0084] Example 3

[0085] This embodiment provides a feed for pigs at different growth stages, the feed comprising pig feed for piglets and pig feed for adult piglets, calculated by weight:

[0086] The pig feed for piglets is composed of 200 parts of wheat with a crushing particle size of 400 μm, 220 parts of cottonseed meal with a crushing particle size of 400 μm, 40 parts of soybean meal with a crushing particle size of 400 μm, 22 parts of fish meal with a crushing particle size of 400 μm, 6 parts of soybean meal exosomes, 6 parts of cottonseed meal exosomes, 0.5 parts of non-starch polysaccharide enzyme, 0.5 parts of protease, 6 parts of amino acids, 5 parts of probiotics and 0.5 parts of premix; wherein,

[0087] The non-starch polysaccharide enzymes consist of cellulase and xylanase in a weight ratio of 3:2;

[0088] The protease consists of pepsin and cathepsin in a weight ratio of 0.5:1;

[0089] The amino acids consist of lysine, methionine, tryptophan, and phenylalanine;

[0090] The probiotics consisted of Lactococcus lactis, Bacillus licheniformis, and Saccharomyces cerevisiae;

[0091] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0092] The pig feed for adult pigs is composed of 180 parts of wheat with a crushing particle size of 600 μm, 200 parts of cottonseed meal with a crushing particle size of 600 μm, 40 parts of dephenolized cottonseed protein with a crushing particle size of 600 μm, 22 parts of stone powder with a crushing particle size of 600 μm, 8 parts of wheat exosomes, 7 parts of cottonseed meal exosomes, 0.8 parts of non-starch polysaccharide enzyme, 0.8 parts of protease, 5 parts of amino acids, 3 parts of probiotics and 0.4 parts of premix; wherein,

[0093] The non-starch polysaccharide enzyme consists of glucanase and pectinase in a weight ratio of 2:1;

[0094] The protease consisted of trypsin and papain in a weight ratio of 1:1;

[0095] The amino acids consist of threonine, valine, leucine, and isoleucine;

[0096] The probiotics consisted of Lactobacillus plantarum, Bacillus subtilis, and Saccharomyces cerevisiae;

[0097] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0098] Comparative Example 1

[0099] This comparative example provides a feed for pigs at different growth stages, wherein the feed includes pig feed for piglets and pig feed for adult piglets, and the feed is calculated by weight.

[0100] The pig feed for piglets is composed of 200 parts of wheat with a crushing particle size of 400 μm, 220 parts of cottonseed meal with a crushing particle size of 400 μm, 40 parts of soybean meal with a crushing particle size of 400 μm, 22 parts of fish meal with a crushing particle size of 400 μm, 6 parts of soybean meal exosomes, 6 parts of cottonseed meal exosomes, 0.5 parts of non-starch polysaccharide enzyme, 0.5 parts of protease, 6 parts of amino acids, 5 parts of probiotics and 0.5 parts of premix; wherein,

[0101] The non-starch polysaccharide enzymes consist of cellulase and xylanase in a weight ratio of 3:2;

[0102] The protease consists of pepsin and cathepsin in a weight ratio of 0.5:1;

[0103] The amino acids consist of lysine, methionine, tryptophan, and phenylalanine;

[0104] The probiotics consisted of Lactococcus lactis, Bacillus licheniformis, and Saccharomyces cerevisiae;

[0105] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0106] The pig feed for the adult pig stage is the same as the pig feed for the piglet stage in Example 3 of the present invention.

[0107] Comparative Example 2

[0108] This comparative example provides a feed for pigs at different growth stages, wherein the feed includes pig feed for piglets and pig feed for adult piglets, and the feed is calculated by weight.

[0109] The pig feed for the piglet stage is prepared from the feed formula disclosed in CN106387413A.

[0110] The pig feed for adult pigs is composed of 180 parts of wheat with a crushing particle size of 600 μm, 200 parts of cottonseed meal with a crushing particle size of 600 μm, 40 parts of dephenolized cottonseed protein with a crushing particle size of 600 μm, 22 parts of stone powder with a crushing particle size of 600 μm, 8 parts of wheat exosomes, 7 parts of cottonseed meal exosomes, 0.8 parts of non-starch polysaccharide enzyme, 0.8 parts of protease, 5 parts of amino acids, 3 parts of probiotics and 0.4 parts of premix; wherein,

[0111] The non-starch polysaccharide enzyme consists of glucanase and pectinase in a weight ratio of 2:1;

[0112] The protease consisted of trypsin and papain in a weight ratio of 1:1;

[0113] The amino acids consist of threonine, valine, leucine, and isoleucine;

[0114] The probiotics consisted of Lactobacillus plantarum, Bacillus subtilis, and Saccharomyces cerevisiae;

[0115] The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

[0116] Experiment 1: Immunity Experiment

[0117] Test samples: feeds for pigs at different growth stages provided in Examples 1-3 and Comparative Examples 1-2 of the present invention.

[0118] Experimental method: By feeding different feeds to pigs at different growth stages, specifically, feeding pig feed for piglets from birth to the 8th month, and feeding pig feed for adult pigs from the 8th month to the 11th month, the immune effect was observed. There were 400 pigs in each group. This experiment was conducted in the nursery house of Zhongsheng Agriculture and Animal Husbandry Phase I Pig Farm, and the results are shown in Table 1 below.

[0119] Table 1 Effects of different feeds on pig immunity

[0120]

[0121] From Table 1, we can see that:

[0122] The present invention optimizes the raw material ratio, adjusts the crushing particle size and adds specific functional ingredients (such as exosomes, enzyme preparations, amino acids, and probiotics) to propose a new feed formula. Pig feed for the piglet stage is fed to the piglets, and pig feed for the adult pig stage is fed to the adult pigs. Full-stage feeding intervention is carried out according to the characteristics of pigs in different growth stages, thereby ensuring the normal nutritional intake needs of pigs in all stages, and improving the immunity of pigs and the disease resistance of pigs in the progressive staged feeding process, thereby preventing pigs from being attacked by foot-and-mouth disease, influenza, and infectious gastroenteritis, thereby promoting the healthy growth of pigs and improving breeding efficiency.

[0123] In order to further demonstrate the beneficial effects of the present invention, the present invention does not add soybean meal exosomes and / or cottonseed meal exosomes to the pig feed for the piglet stage, and the present invention does not add wheat exosomes and / or cottonseed meal exosomes to the pig feed for the adult pig stage. Other conditions are consistent with Example 3. The results show that its effect on pig immunity is equivalent to that of Comparative Example 2.

[0124] In order to further demonstrate the beneficial effects of the present invention, the soybean meal exosomes in the pig feed for the piglet stage are replaced by soybean meal extract, and the cottonseed meal exosomes are replaced by cottonseed meal extract; the wheat exosomes in the pig feed for the adult pig stage are replaced by wheat extract, and the cottonseed meal exosomes are replaced by cottonseed meal extract. The other conditions are consistent with those in Example 3. The results show that its effect on pig immunity is equivalent to that of Comparative Example 2.

[0125] In order to further demonstrate the beneficial effects of the present invention, the present invention adjusts the grinding particle size of wheat, cottonseed meal, soybean meal and fish meal in pig feed for piglets to 350 μm or 450 μm; the grinding particle size of wheat, cottonseed meal, dephenolized cottonseed protein and stone powder in pig feed for adult pigs to 550 μm or 700 μm; other conditions are consistent with those in Example 3. The results show that its effect on pig immunity is equivalent to that of Comparative Example 2.

[0126] Experiment 2: Growth performance experiment

[0127] Test samples: feed for pigs at different growth stages provided in Example 1, Example 3 and Comparative Example 1 of the present invention.

[0128] Experimental method: Feed different feeds to pigs to observe the effects of different feeds on pig growth performance. Each group has 200 pigs. The results are shown in Table 2 below. This experiment was conducted in the nursery house of Zhongsheng Agriculture and Animal Husbandry Phase I Pig Farm for a total of 21 days.

[0129] Table 2 Effects of different feeds on pig growth performance

[0130] project Example 1 Example 3 Comparative Example 1 Average sample weight (kg) 9.79±0.23 9.81±0.25 9.83±0.17 Final average weight (kg) 19.96±0.32 24.05±0.35 19.81±0.66 Average daily weight gain (g / d) 487.52±12.22 527.68±12.34 452.80±13.41 Average daily feed intake (g / d) 711.21±18.30 710.72±17.52 721.30±20.27 Diarrhea rate (%) 4.43±0.50 3.51±0.26 9.54±0.28

[0131] From Table 2, we can see that:

[0132] The present invention optimizes the raw material ratio, adjusts the crushing particle size, and adds specific functional ingredients (such as exosomes, enzyme preparations, amino acids, and probiotics) to propose a new feed formula. The piglets are fed with pig feed for the piglet stage, and the adult pigs are fed with pig feed for the adult pig stage. The feeding intervention is carried out in all stages according to the characteristics of different growth stages of pigs, thereby ensuring the normal nutritional intake requirements of pigs at all stages, and improving the growth performance of pigs in the progressive staged feeding process. The feeding effect and the effect of reducing diarrhea rate of Example 1 and Example 3 are better than those of Comparative Example 1, among which the effect of Example 3 is the best.

[0133] In addition, the present invention feeds pigs with different feeds for pigs at different growth stages provided in Example 2 and Comparative Example 2, respectively. The results show that the feeding effect and the effect of reducing the diarrhea rate of Example 2 are equivalent to those of Example 1, and the feeding effect and the effect of reducing the diarrhea rate of Comparative Example 2 are equivalent to those of Comparative Example 1.

[0134] In order to further demonstrate the beneficial effects of the present invention, the present invention does not add soybean meal exosomes and / or cottonseed meal exosomes to the pig feed used in the piglet stage, and the present invention does not add wheat exosomes and / or cottonseed meal exosomes to the pig feed used in the adult pig stage. The other conditions are consistent with those in Example 3. The results show that the feeding effect and the effect of reducing the diarrhea rate are equivalent to those of Comparative Example 1.

[0135] In order to further demonstrate the beneficial effects of the present invention, the soybean meal exosomes in the pig feed for the piglets were replaced with soybean meal extract, and the cottonseed meal exosomes were replaced with cottonseed meal extract; the wheat exosomes in the pig feed for the adult pigs were replaced with wheat extract, and the cottonseed meal exosomes were replaced with cottonseed meal extract. The other conditions were the same as those in Example 3. The results showed that the feeding effect and the effect of reducing the diarrhea rate were comparable to those in Comparative Example 1.

[0136] In order to further demonstrate the beneficial effects of the present invention, the present invention adjusts the grinding particle size of wheat, cottonseed meal, soybean meal and fish meal in pig feed for piglets to 350 μm or 450 μm; the grinding particle size of wheat, cottonseed meal, dephenolized cottonseed protein and stone powder in pig feed for adult pigs to 550 μm or 700 μm; other conditions are consistent with those in Example 3. The results show that its feeding effect and the effect of reducing diarrhea rate are equivalent to those of Comparative Example 1.

[0137] Through Experiments 1 and 2, it can be known that the feed for pigs in different growth stages provided by the present invention is a whole. Specifically, the functions of the raw materials in the pig feed for the piglet stage support each other and interact with each other; the functions of the raw materials in the pig feed for the adult pig stage support each other and interact with each other. It is precisely because the functions of the raw materials support each other and interact with each other that the present invention has the technical effect of improving immunity and improving growth performance.

[0138] It should be understood that the disclosed invention is not limited only to the specific method, scheme and material of description, because these all can change.It should also be understood that the terminology used herein is only for the purpose of describing specific embodiment scheme, rather than being intended to limit the scope of the present invention, and the scope of the present invention is only limited to the appended claims.

[0139] Those skilled in the art will also recognize, or be able to ascertain, using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are also included in the appended claims. It should be noted that the various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same and similar parts between the various embodiments can be referred to each other.

[0140] Although the optional embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including optional embodiments and all changes and modifications that fall within the scope of the embodiments of the present invention.

[0141] The technical solution provided by the present invention is introduced in detail above. Specific examples are used in this article to illustrate the principle and implementation mode of the present invention. At the same time, for those skilled in the art, according to the principle and implementation mode of the present invention, there will be changes in the specific implementation mode and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A feed for pigs at different growth stages, characterized in that: The feed includes pig feed for piglets and pig feed for adult piglets, wherein: The pig feed for piglets is composed of wheat with a crushing particle size of 400-420 μm, cottonseed meal with a crushing particle size of 400-420 μm, soybean meal with a crushing particle size of 400-420 μm, fish meal with a crushing particle size of 400-420 μm, soybean meal exosomes, cottonseed meal exosomes, non-starch polysaccharide enzymes, proteases, amino acids, probiotics and premixes; The pig feed for adult pigs consists of wheat with a crushing particle size of 600-650 μm, cottonseed meal with a crushing particle size of 600-650 μm, dephenolized cottonseed protein with a crushing particle size of 600-650 μm, stone powder with a crushing particle size of 600-650 μm, wheat exosomes, cottonseed meal exosomes, non-starch polysaccharide enzymes, proteases, amino acids, probiotics and premixes.

2. The feed according to claim 1, measured by weight: The pig feed for the piglet stage consists of 200-220 parts of wheat with a crushed particle size of 400-420 μm, 200-220 parts of cottonseed meal with a crushed particle size of 400-420 μm, 40-45 parts of soybean meal with a crushed particle size of 400-420 μm, 20-25 parts of fish meal with a crushed particle size of 400-420 μm, 5-8 parts of soybean meal exosomes, 5-8 parts of cottonseed meal exosomes, 0.5-1 part of non-starch polysaccharide enzyme, 0.5-1 part of protease, 5-7 parts of amino acids, 3-6 parts of probiotics and 0.3-0.5 parts of premix.

3. The feed according to claim 1, measured by weight: The pig feed for adult pigs consists of 180-200 parts of wheat with a crushing particle size of 600-650 μm, 180-200 parts of cottonseed meal with a crushing particle size of 600-650 μm, 35-40 parts of dephenolized cottonseed protein with a crushing particle size of 600-650 μm, 20-22 parts of stone powder with a crushing particle size of 600-650 μm, 8-10 parts of wheat exosomes, 7-10 parts of cottonseed meal exosomes, 0.8-1.2 parts of non-starch polysaccharide enzyme, 0.8-1.2 parts of protease, 5-6 parts of amino acids, 3-5 parts of probiotics and 0.3-0.5 parts of premix.

4. The feed according to claim 2, measured by weight: The non-starch polysaccharide enzyme consists of cellulase and xylanase in a weight ratio of 3:2; The protease is composed of pepsin and cathepsin in a weight ratio of 0.5:1; The amino acids consist of lysine, methionine, tryptophan and phenylalanine; The probiotics consist of Lactococcus lactis, Bacillus licheniformis and Saccharomyces cerevisiae; The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

5. The feed according to claim 3, measured by weight: The non-starch polysaccharide enzyme is composed of glucanase and pectinase in a weight ratio of 2:1; The protease consists of trypsin and papain in a weight ratio of 1:1; The amino acids consist of threonine, valine, leucine and isoleucine; The probiotics consist of Lactobacillus plantarum, Bacillus subtilis and Saccharomyces cerevisiae; The premix consists of calcium hydrogen phosphate, vitamin A and vitamin D.

6. The feed according to claim 2, measured by weight, The pig feed for the piglet stage consists of 200 parts of wheat with a crushed particle size of 400 μm, 220 parts of cottonseed meal with a crushed particle size of 400 μm, 40 parts of soybean meal with a crushed particle size of 400 μm, 22 parts of fish meal with a crushed particle size of 400 μm, 6 parts of soybean meal exosomes, 6 parts of cottonseed meal exosomes, 0.5 parts of non-starch polysaccharide enzyme, 0.5 parts of protease, 6 parts of amino acids, 5 parts of probiotics and 0.5 parts of premix.

7. The feed according to claim 3, calculated by weight: The pig feed for adult pigs consists of 180 parts of wheat with a crushed particle size of 600 μm, 200 parts of cottonseed meal with a crushed particle size of 600 μm, 40 parts of dephenolized cottonseed protein with a crushed particle size of 600 μm, 22 parts of stone powder with a crushed particle size of 600 μm, 8 parts of wheat exosomes, 7 parts of cottonseed meal exosomes, 0.8 parts of non-starch polysaccharide enzyme, 0.8 parts of protease, 5 parts of amino acids, 3 parts of probiotics and 0.4 parts of premix.

8. Use of the feed according to any one of claims 1 to 7 in feeding pigs at different growth stages.

9. Use of the feed according to any one of claims 1 to 7 in improving pig immunity and / or improving pig growth performance.

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