Combination of self-assembled peptide matrix and hydroxyapatite for regeneration and remodeling of enamel

Abstract

The invention relates to the technical field of tooth enamel regeneration and remodeling, and discloses a combination of a self-assembly peptide matrix and hydroxyapatite for tooth enamel regeneration and remodeling, which is characterized by comprising the following main components: self-assembly peptide and hydroxyapatite, and the self-assembly peptide is a bionic peptide chain self-assembly matrix. After the structure is adopted, the peptide matrix scaffold has the following advantages that hydroxyapatite is only supplemented for tooth enamel and is very difficult to adsorb and absorb by the tooth enamel, by using the self-assembled peptide matrix, peptide is diffused into an early-stage decayed tooth lesion body through a complete low-mineralization plate and begins to be self-assembled, and the peptide matrix scaffold simulating a tooth enamel matrix is generated; the matrix scaffold adsorbs free calcium and phosphate ions in oral saliva and serves as a nucleation point of hydroxyapatite to trigger a deep remineralization and repair mechanism of natural bionic enamel so as to form regeneration of damaged enamel.

Description

Technical Field

[0001] The present invention relates to the technical field of tooth enamel regeneration and remodeling, and in particular to a self-assembling peptide matrix combined with hydroxyapatite for tooth enamel regeneration and remodeling, so as to regenerate and remodel the tooth enamel, balance daily tooth demineralization and remineralization, and prevent and repair early caries lesions. Background Art

[0002] Common treatments for dental lesions, especially caries lesions, are fillings and drilling. To date, once a caries lesion has formed a cavity, a hole has appeared in the tooth, the commonly used treatment methods are invasive. For example, destructive dental drilling surgery is used to remove the decayed material. Alternatively, caries can be removed using lasers, dental spoons or chemical mechanical systems.

[0003] After the carious enamel and / or dentin has been removed (i.e., excavated), the missing tooth structure requires the application of dental restorative materials such as sealants, amalgam, dental composites, porcelain, or gold.

[0004] Saliva contains a certain concentration of calcium ions and phosphate ions, which can buffer the changes in saliva pH to a certain extent, thereby inhibiting the dissolution of hydroxyapatite. When the pH is greater than 5.5 and the concentrations of calcium ions and phosphate ions are high, calcium phosphate is generated in the saliva, allowing demineralized teeth to remineralize. Normally, the concentrations of calcium ions and phosphate ions in saliva are low, making it difficult to form sufficient amounts of hydroxyapatite to balance demineralization and repair demineralized enamel. Summary of the invention

[0005] The present invention aims to solve the problem that the concentrations of calcium ions and phosphate ions contained in saliva are low, making it difficult to form a sufficient amount of hydroxyapatite to repair demineralized tooth enamel, and to provide a self-assembling peptide matrix combined with hydroxyapatite for tooth enamel regeneration and remodeling.

[0006] In order to solve the above technical problems, the technical solution provided by the present invention is: a self-assembling peptide matrix is ​​combined with hydroxyapatite for enamel regeneration and remodeling, characterized in that it includes: main components: self-assembling peptides and hydroxyapatite, and the self-assembling peptides are bionic peptide chain self-assembling matrices.

[0007] After adopting the above structure, the present invention has the following advantages: simply supplementing hydroxyapatite to the enamel is difficult to be adsorbed and absorbed by the enamel. By using a self-assembling peptide matrix, the peptide diffuses into the early caries lesion through the complete low mineralization plate and begins to self-assemble to produce a peptide matrix scaffold that mimics the enamel matrix. The matrix scaffold adsorbs free calcium and phosphate ions in oral saliva and serves as a nucleation point for hydroxyapatite, triggering a natural bionic enamel deep remineralization and repair mechanism to form regeneration of damaged enamel.

[0008] As an improvement, the self-assembling peptide is a long peptide of 11 amino acids synthesized from five amino acids, namely glutamine, glutamic acid, phenylalanine, tryptophan and arginine, according to a specific sequence. The resulting high molecular structure has a high affinity for tooth minerals.

[0009] As an improvement, the specific amino acid sequence is: glutamine-glutamine-arginine-phenylalanine-glutamate-tryptophan-glutamate-phenylalanine-glutamate-glutamine-glutamine.

[0010] As an improvement, the hydroxyapatite is an important component of tooth enamel, accounting for 96% of the tooth enamel composition, and the rest is 3.5% water and 1.5% organic matter.

[0011] As an improvement, the self-assembling peptide and hydroxyapatite are applied to tooth enamel regeneration and remodeling essence and tooth enamel regeneration and remodeling toothpaste. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 A diagram showing the enamel regeneration process using enamel regeneration essence or enamel regeneration toothpaste. DETAILED DESCRIPTION

[0013] A self-assembling peptide matrix combined with hydroxyapatite for tooth enamel regeneration and remodeling, characterized by: comprising:

[0014] The main ingredients are: self-assembling peptides and hydroxyapatite;

[0015] The self-assembling peptide is a long peptide of 11 amino acids synthesized from five amino acids, namely glutamine, glutamic acid, phenylalanine, tryptophan and arginine, according to a specific sequence. The resulting high molecular structure has a high affinity for tooth minerals.

[0016] The specific amino acid sequence is: glutamine-glutamine-arginine-phenylalanine-glutamic acid-tryptophan-glutamic acid-phenylalanine-glutamic acid-glutamine-glutamine.

[0017] The hydroxyapatite is an important component of tooth enamel, accounting for 96% of the tooth enamel components, and the rest is 3.5% of water and 1.5% of organic matter.

[0018] The self-assembling peptide and hydroxyapatite are applied to tooth enamel regeneration and remodeling essence or tooth enamel regeneration and remodeling toothpaste.

[0019] According to the attached Figure 1As shown, by applying self-assembling peptides on the tooth surface, the peptides diffuse into the early caries lesions through the intact hypomineralized plate and begin to self-assemble, producing a peptide matrix scaffold that mimics the enamel matrix due to the low pH of such lesions. Around the newly formed matrix, the re-formed enamel crystals are formed of calcium phosphate. Through remineralization, caries activity is significantly reduced compared to fluoride alone. In the product, the peptide is present in the form of a matrix. It directly binds to the tooth mineral as a matrix and forms a stable layer of regenerated mineral crystals on the tooth. This layer does protect the tooth from acid attack. It also plugs the open dentinal tubules, thereby reducing tooth sensitivity.

[0020] The following is the application formula of the self-assembling peptide matrix combined with hydroxyapatite in the enamel regeneration and remodeling essence and enamel regeneration and remodeling toothpaste:

[0021] The enamel regeneration and remodeling essence is an essence paste applied to teeth. The main ingredients of the formula include: sorbitol, water, hydrated silica, pentylene glycol, hydroxyapatite, mannitol, polyethylene glycol, cellulose gum, sodium hydroxide, citric acid, sodium saccharin, self-assembling peptides (a high-molecular-weight long peptide of 11 amino acids synthesized from five amino acids, glutamine, glutamic acid, phenylalanine, tryptophan and arginine, according to the sequence of glutamine-glutamine-arginine-phenylalanine-glutamic acid-tryptophan-glutamic acid-phenylalanine-glutamate-glutamine-glutamine), calcium hydrogen phosphate and calcium glycerophosphate.

[0022] The main ingredients of the enamel regeneration and remodeling toothpaste formula include: water, hydrated silica, hydrogenated glucose syrup, glycerin, hydroxyapatite, xylitol, sodium lauryl sulfate, calcium carbonate, sodium monofluorophosphate, xanthan gum, citric acid, peppermint extract, menthol, zinc lactate, potassium sorbate, sodium benzoate, alpine edelweiss extract, limonene, self-assembling peptide (a high-molecular-weight long peptide of 11 amino acids synthesized from five amino acids, glutamine, glutamic acid, phenylalanine, tryptophan and arginine, according to the sequence of glutamine-glutamine-arginine-phenylalanine-glutamic acid-tryptophan-glutamic acid-phenylalanine-glutamic acid-glutamine-glutamine).

[0023] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0024] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0025] The present invention and its implementation methods are described above, and such description is not restrictive. In short, if ordinary technicians in the field are inspired by it and do not deviate from the purpose of the invention, they can creatively design structures and embodiments similar to the technical solution, which should all fall within the protection scope of the present invention.

Claims

1. The self-assembling peptide matrix combined with hydroxyapatite is used for tooth enamel regeneration and remodeling, characterized by: include, The main ingredients are: self-assembling peptides and hydroxyapatite.

2. The self-assembling peptide matrix according to claim 1 is combined with hydroxyapatite for use in tooth enamel regeneration and remodeling, characterized in that: The self-assembling peptide is a long peptide of 11 amino acids synthesized from five amino acids, namely glutamine, glutamic acid, phenylalanine, tryptophan and arginine, according to a specific sequence. The resulting high molecular structure has a high affinity for tooth minerals.

3. The self-assembling peptide matrix according to claim 2 is combined with hydroxyapatite for use in tooth enamel regeneration and remodeling, characterized in that: The specific amino acid sequence is: glutamine-glutamine-arginine-phenylalanine-glutamic acid-tryptophan-glutamic acid-phenylalanine-glutamic acid-glutamine-glutamine.

4. The self-assembling peptide matrix according to claim 1 is combined with hydroxyapatite for use in tooth enamel regeneration and remodeling, characterized in that: The hydroxyapatite is an important component of tooth enamel, accounting for 96% of the tooth enamel components, and the rest is 3.5% of water and 1.5% of organic matter.

5. The self-assembling peptide matrix according to claim 1 is combined with hydroxyapatite for use in tooth enamel regeneration and remodeling, characterized in that: The self-assembling peptide and hydroxyapatite are applied to tooth enamel regeneration and remodeling essence and tooth enamel regeneration and remodeling toothpaste.

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