Oral traditional Chinese medicine formula for treating type II diabetes mellitus and preparation method of oral traditional Chinese medicine formula

Abstract

The invention discloses an oral traditional Chinese medicine formula for treating type II diabetes and a preparation method of the oral traditional Chinese medicine formula. The traditional Chinese medicine composition is prepared from 20-40 parts of ginseng, 10-20 parts of radix astragali, 10-20 parts of gecko, 10-20 parts of male silkworm moth, 10-20 parts of artemisia anomala, 4-8 parts of radix bupleuri, 6-12 parts of radix angelicae pubescentis, 5-10 parts of radix puerariae, 10-20 parts of fried fructus arctii, 5-10 parts of herba lycopi, 10-20 parts of radix rehmanniae, 10-20 parts of ramuli euonymi, 10-20 parts of rhizoma polygonati, 10-20 parts of radix polygonati officinalis and 20-40 parts of radix cynanchi auriculati. By adopting the oral medicine formula, the repair and regeneration of pancreatic beta cells can be promoted, the sensitivity of insulin can be improved, and the resistance of the insulin can be relieved. The pathogenesis of the type II diabetes mellitus is accompanied by pancreatic islet resistance due to insufficiency of insulin secretion, and the medicines can tonify qi and invigorate the spleen, nourish yin and nourish the kidney, promote the circulation of qi and remove stasis, and astringe the liver to remove blood stasis, and have the effect of smoothing fourteen meridians.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine formulas for diabetes, and in particular to an oral Chinese medicine formula for treating type II diabetes and a preparation method thereof. Background Art

[0002] Patients with type 2 diabetes are generally obese people, middle-aged and elderly people, and those suffering from hypertension, hyperlipidemia, and hyperuricemia. People who drink alcohol and smoke a lot are also prone to type 2 diabetes. If you suffer from type 2 diabetes and ignore it, you will develop the disease and it will worsen day by day, and you will develop diabetic ketoacidosis, diabetic nephropathy, diabetic retinopathy, peripheral neuropathy, cardiovascular and cerebrovascular and lower limb arteriosclerosis, etc.

[0003] Type 2 diabetes is the most common type of diabetes. The disease is caused by a variety of factors that lead to insufficient insulin secretion or the body's inability to effectively utilize insulin, resulting in a continuous increase in blood sugar levels.

[0004] Diabetes is a common and frequent disease nowadays, and its incidence rate is increasing year by year. It is more common in middle-aged and elderly people, bringing serious physical and psychological burdens to patients due to the hazards and mortality rate caused by its complications. At present, the treatment for diabetes is mainly Western medicine, which can cause damage to liver and kidney function. Among the current clinical treatment drugs for the pathogenesis of type 2 diabetes, there are metformin and glitazones that improve insulin resistance, insulin secretagogues sulfonylureas and glinides, α-glucosidase inhibitors that inhibit gastrointestinal glucose absorption, and incretin hypoglycemic drugs such as glucagon-like polypeptide 1 analogs or its receptor agonists, DDP-IV inhibitors, and insulin. Although the above Western medicines have certain effects on the treatment of type 2 diabetes, they have the disadvantages of large side effects or slow effects and unstable efficacy. First of all, the most common thing is that some patients are prone to gastrointestinal discomfort after taking Western medicine, such as nausea, vomiting, abdominal pain, diarrhea, constipation, bloating, indigestion, and heartburn. Some people also experience dizziness, headache, flu-like symptoms, abnormal taste, muscle pain, hypotension, palpitations, flushing, and some patients will experience rash, fatigue, fatigue, etc. As the disease progresses, the dosage of drug treatment gradually increases with drug resistance, and the efficacy is not good. Existing Chinese patent medicines such as Xiaoke Pills also have many limitations and cannot solve the problem fundamentally.

[0005] In fact, the treatment of type 2 diabetes is not essentially about the lack of insulin, but about the damage to the pancreatic islets, the obstruction of β-cell secretion and the resistance of the pancreatic islets.

[0006] Therefore, it is urgent to provide a Chinese medicine formula for oral administration and a preparation method for treating type 2 diabetes. Summary of the invention

[0007] To solve the above technical problems, the technical solution provided by the present invention is: an oral Chinese medicine formula for treating type 2 diabetes and a preparation method, comprising the following components by weight: 20-40 parts of ginseng, 10-20 parts of astragalus, 10-20 parts of gecko, 10-20 parts of male silkworm moth, 10-20 parts of Liu Jinu, 4-8 parts of bupleurum, 6-12 parts of angelica, 5-10 parts of kudzu root, 10-20 parts of stir-fried burdock seeds, 5-10 parts of zelan, 10-20 parts of radix rehmanniae, 10-20 parts of euphorbia pulex, 10-20 parts of polygonatum, 10-20 parts of polygonatum and 20-40 parts of clematis.

[0008] Further, it includes the following components by weight: 20 parts of ginseng, 10 parts of astragalus, 10 parts of gecko, 10 parts of male silkworm moth, 10 parts of Liu Jinu, 4 parts of bupleurum, 6 parts of angelica, 5 parts of kudzu root, 10 parts of stir-fried burdock seeds, 5 parts of zelan, 10 parts of radix rehmanniae, 10 parts of euphorbia pulex, 10 parts of polygonatum, 10 parts of polygonatum and 20 parts of clematis.

[0009] Further, the following components by weight are included, including the following components by weight, 30 parts of ginseng, 15 parts of astragalus, 15 parts of gecko, 15 parts of male silkworm moth, 15 parts of Liu Jinu, 5 parts of bupleurum, 10 parts of angelica root, 6 parts of kudzu root, 15 parts of stir-fried burdock seeds, 6 parts of zelan, 15 parts of raw rehmannia, 15 parts of ghost arrow feather, 15 parts of polygonatum, 15 parts of polygonatum and 30 parts of clematis.

[0010] Further, it includes the following components by weight: 35 parts of ginseng, 18 parts of astragalus, 18 parts of gecko, 18 parts of male silkworm moth, 18 parts of Liu Jinu, 6 parts of bupleurum, 11 parts of angelica root, 8 parts of kudzu root, 18 parts of stir-fried burdock seeds, 8 parts of zelan, 18 parts of radix rehmanniae, 18 parts of euphorbia pulex, 18 parts of polygonatum, 18 parts of polygonatum and 35 parts of clematis.

[0011] Further, it includes the following components by weight: 40 parts of ginseng, 20 parts of astragalus, 20 parts of gecko, 20 parts of male silkworm moth, 20 parts of Liu Jinu, 8 parts of bupleurum, 12 parts of angelica root, 10 parts of kudzu root, 20 parts of stir-fried burdock seeds, 10 parts of zelan, 20 parts of radix rehmanniae, 20 parts of euphorbia pulex, 20 parts of polygonatum, 20 parts of polygonatum and 40 parts of clematis.

[0012] The advantages of the invention compared with the prior art are:

[0013] Ginseng is a kind of Chinese herbal medicine. It is sweet, nourishing and warm in nature. It is anti-stress and belongs to the spleen and lung meridians. It can greatly replenish vital energy and also has the function of invigorating qi. If patients with hypertension and diabetes experience symptoms such as spleen and stomach qi stagnation, abdominal distension and pain, physical weakness, cold limbs and weak pulse, they can take ginseng to relieve symptoms. Geshanxiao can be used to treat stomach pain and fullness.

[0014] Astragalus can replenish Qi and raise Yang, benefit the Wei and consolidate the exterior, promote diuresis and reduce swelling, promote the production of body fluids and nourish the blood, relieve stagnation and relieve numbness, increase the sensitivity of the pancreas and has a dual regulatory effect. It can protect the liver, reduce inflammation, is warm in nature, sweet in taste, and enters the spleen and lung meridians.

[0015] Gecko is salty and flat in nature, and enters the lung and kidney meridians. It can nourish the lungs and kidneys, assist yang and benefit essence, absorb qi and relieve asthma. It can enhance immunity and has anti-aging, anti-allergic, blood sugar-lowering, antispasmodic and antiasthmatic effects.

[0016] Male silkworm moth contains natural insulin, and can strengthen the liver and kidneys. It is salty and warm in nature, and enters the liver and kidney meridians.

[0017] Burdock seeds are pungent, bitter and cold, and belong to the lung and stomach meridians. They can dredge the lungs and relieve throat, open the twelve meridians, eliminate wind, remove erysipelas, improve eyesight, disperse and clear nodules, and can also be used to prevent and treat diabetic nephropathy.

[0018] Bupleurum has similar effects to glucosidase inhibitors, protecting the liver, promoting bile secretion, and enhancing immunity.

[0019] Pueraria root, with a cool nature, belongs to the spleen and stomach meridians, produces fluid, quenches thirst, activates collaterals, improves insulin sensitivity, and reduces insulin resistance. "Medical Origin" says: "It eliminates thirst caused by spleen and stomach deficiency heat." "Compendium of Materia Medica" says: "It disperses stagnant fire." Li Gao's "Medical Methods" says: "Dried kudzu root has a light and floating gas, which can stimulate the upward movement of stomach qi, produce body fluid, and relieve muscle heat. It is also a holy medicine for treating diarrhea caused by spleen and stomach deficiency." Lai Jianyou and others pointed out that puerarin can enhance insulin sensitivity and has a certain effect on diabetes. Zhang Da and others found that puerarin can reduce the content of protein kinase R-like endoplasmic reticulum kinase, eukaryotic initiation factor 2a and glucose-regulated protein 78 in mice with type 2 diabetes model, thereby reducing the endoplasmic reticulum stress of the kidney and playing a role in lowering blood sugar. Liu Siyang and others found that total flavonoids from pueraria root can reduce the content of serum reduced glutathione and nitric oxide synthase in rats with type 2 diabetes model, enhance the expression of pancreatic tissue-related proteases, and play a role in lowering blood sugar and blood lipids.

[0020] Angelica dahurica is pungent in nature and flavor, slightly cooling, and enters the stomach and bladder meridians. It has a sedative, analgesic, anti-inflammatory and hypnotic effect.

[0021] Ghost arrow feather has the effect of lowering blood sugar and maintaining blood sugar.

[0022] Ze Lan is a traditional Chinese medicine with bitter and spicy taste and slightly warm nature. It belongs to the liver meridian and spleen meridian. It has the effects and functions of promoting blood circulation, promoting diuresis, reducing swelling, relieving pain, and nourishing the liver.

[0023] Liu Jinu is bitter and warm in nature, and enters the heart meridian, liver meridian and spleen meridian. Its efficacy and function are to promote blood circulation and dredge menstruation, disperse blood stasis and relieve pain, stop bleeding and reduce swelling, and help digestion and resolve accumulation. It can also effectively treat inflammation.

[0024] The oral drug formula of the present invention can promote the repair and regeneration of pancreatic beta cells, improve insulin sensitivity, and reduce insulin resistance. The cause of type 2 diabetes is still due to insufficient insulin secretion accompanied by pancreatic resistance. The oral drug formula of the present invention is also in line with the theory of traditional Chinese medicine in a macro sense. The above-mentioned medicine can replenish qi and strengthen the spleen, nourish yin and tonify the kidney, promote qi and disperse stagnation, restrain the liver and remove blood stasis, and has the effect of unblocking fourteen meridians.

[0025] The present invention adopts the above-mentioned oral medicine to treat diabetes. Under the guidance of traditional Chinese medicine theory and clinical experience, the raw materials and their proportions are carefully selected, and the synergistic or resistant effects between them are utilized to improve the therapeutic effect. The medicine has significant therapeutic effect, less side effects than Western medicine, simple preparation and low cost. DETAILED DESCRIPTION

[0026] The present invention is further described in detail below with reference to specific embodiments.

[0027] The present invention provides a Chinese medicine formula for internal use for treating type II diabetes and a preparation method thereof, comprising the following components by weight: 20-40 parts of ginseng, 10-20 parts of astragalus, 10-20 parts of gecko, 10-20 parts of male silkworm moth, 10-20 parts of aconite, 4-8 parts of bupleurum, 6-12 parts of angelica root, 5-10 parts of kudzu root, 10-20 parts of stir-fried burdock fruit, 5-10 parts of zedoaria, 10-20 parts of radix rehmanniae, 10-20 parts of euphorbia pulex, 10-20 parts of polygonatum, 10-20 parts of polygonatum and 20-40 parts of clematis.

[0028] Embodiment 1:

[0029] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 20 parts of ginseng, 10 parts of astragalus, 10 parts of gecko, 10 parts of male silkworm moth, 10 parts of Liu Jinu, 4 parts of bupleurum, 6 parts of angelica, 5 parts of kudzu root, 10 parts of stir-fried burdock fruit, 5 parts of zelan, 10 parts of radix rehmanniae, 10 parts of euphorbia pulex, 10 parts of polygonatum, 10 parts of polygonatum and 20 parts of clematis.

[0030] Embodiment 2:

[0031] A Chinese medicine formula for internal use for treating type 2 diabetes comprises the following components by weight: 30 parts of ginseng, 15 parts of astragalus, 15 parts of gecko, 15 parts of male silkworm moth, 15 parts of Liu Jinu, 5 parts of bupleurum, 10 parts of angelica root, 6 parts of kudzu root, 15 parts of stir-fried burdock fruit, 6 parts of zelan, 15 parts of radix rehmanniae, 15 parts of euphorbia pulex, 15 parts of polygonatum, 15 parts of polygonatum and 30 parts of clematis.

[0032] Embodiment three:

[0033] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 35 parts of ginseng, 18 parts of astragalus, 18 parts of gecko, 18 parts of male silkworm moth, 18 parts of aconite, 6 parts of bupleurum, 11 parts of angelica dahurica, 8 parts of kudzu root, 18 parts of stir-fried burdock fruit, 8 parts of zelan, 18 parts of radix rehmanniae, 18 parts of euphorbia pulex, 18 parts of polygonatum, 18 parts of polygonatum and 35 parts of clematis.

[0034] Embodiment 4:

[0035] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 40 parts of ginseng, 20 parts of astragalus, 20 parts of gecko, 20 parts of male silkworm moth, 20 parts of Liu Jinu, 8 parts of bupleurum, 12 parts of angelica root, 10 parts of kudzu root, 20 parts of stir-fried burdock fruit, 10 parts of zelan, 20 parts of radix rehmanniae, 20 parts of euphorbia pulex, 20 parts of polygonatum, 20 parts of polygonatum and 40 parts of clematis.

[0036] Embodiment five:

[0037] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 20 parts of ginseng, 10 parts of astragalus, 10 parts of gecko, 10 parts of male silkworm moth, 10 parts of Liu Jinu, 4 parts of bupleurum, 6 parts of angelica, 5 parts of kudzu root, 10 parts of stir-fried burdock fruit, 5 parts of zelan, 10 parts of radix rehmanniae, 10 parts of euphorbia pulex, 10 parts of polygonatum, 10 parts of polygonatum and 20 parts of clematis.

[0038] Preparation method:

[0039] (1) Stir-fried burdock seeds are prepared by mixing Momordica seeds and burdock seeds in a weight ratio of 1:1. Momordica seeds are first fried until slightly yellow, and then burdock seeds are added and fried together. The burdock seeds are repeatedly fried and then the Momordica seeds are discarded. The fried burdock seeds are used as medicine;

[0040] (2) preparing raw materials according to the above weight components, and mixing and grinding the raw materials into fine powder;

[0041] (3) The ground fine powder is packaged separately, and the weight of each bag of Chinese medicine fine powder is 5-7g.

[0042] As a further explanation of the present invention, the weight of each bag of Chinese medicine fine powder in step (3) is 5 g.

[0043] Embodiment six:

[0044] A Chinese medicine formula for internal use for treating type 2 diabetes comprises the following components by weight: 30 parts of ginseng, 15 parts of astragalus, 15 parts of gecko, 15 parts of male silkworm moth, 15 parts of Liu Jinu, 5 parts of bupleurum, 10 parts of angelica root, 6 parts of kudzu root, 15 parts of stir-fried burdock fruit, 6 parts of zelan, 15 parts of radix rehmanniae, 15 parts of euphorbia pulex, 15 parts of polygonatum, 15 parts of polygonatum and 30 parts of clematis.

[0045] Preparation method:

[0046] (1) Stir-fried burdock seeds are prepared by mixing Momordica seeds and burdock seeds in a weight ratio of 1:1. Momordica seeds are first fried until slightly yellow, and then burdock seeds are added and fried together. The burdock seeds are repeatedly fried and then the Momordica seeds are discarded. The fried burdock seeds are used as medicine;

[0047] (2) preparing raw materials according to the above weight components, and mixing and grinding the raw materials into fine powder;

[0048] (3) The ground fine powder is packaged separately, and the weight of each bag of Chinese medicine fine powder is 5-7g.

[0049] As a further explanation of the present invention, the weight of each bag of Chinese medicine fine powder in step (3) is 5 g.

[0050] Embodiment seven:

[0051] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 35 parts of ginseng, 18 parts of astragalus, 18 parts of gecko, 18 parts of male silkworm moth, 18 parts of aconite, 6 parts of bupleurum, 11 parts of angelica dahurica, 8 parts of kudzu root, 18 parts of stir-fried burdock fruit, 8 parts of zelan, 18 parts of radix rehmanniae, 18 parts of euphorbia pulex, 18 parts of polygonatum, 18 parts of polygonatum and 35 parts of clematis.

[0052] Preparation method:

[0053] (1) Stir-fried burdock seeds are prepared by mixing Momordica seeds and burdock seeds in a weight ratio of 1:1. Momordica seeds are first fried until slightly yellow, and then burdock seeds are added and fried together. The burdock seeds are repeatedly fried and then the Momordica seeds are discarded. The fried burdock seeds are used as medicine;

[0054] (2) preparing raw materials according to the above weight components, and mixing and grinding the raw materials into fine powder;

[0055] (3) The ground fine powder is packaged separately, and the weight of each bag of Chinese medicine fine powder is 5-7g.

[0056] As a further explanation of the present invention, the weight of each bag of Chinese medicine fine powder in step (3) is 5 g.

[0057] Embodiment eight:

[0058] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 40 parts of ginseng, 20 parts of astragalus, 20 parts of gecko, 20 parts of male silkworm moth, 20 parts of Liu Jinu, 8 parts of bupleurum, 12 parts of angelica root, 10 parts of kudzu root, 20 parts of stir-fried burdock fruit, 10 parts of zelan, 20 parts of radix rehmanniae, 20 parts of euphorbia pulex, 20 parts of polygonatum, 20 parts of polygonatum and 40 parts of clematis.

[0059] Preparation method:

[0060] (1) Stir-fried burdock seeds are prepared by mixing Momordica seeds and burdock seeds in a weight ratio of 1:1. Momordica seeds are first fried until slightly yellow, and then burdock seeds are added and fried together. The burdock seeds are repeatedly fried and then the Momordica seeds are discarded. The fried burdock seeds are used as medicine;

[0061] (2) preparing raw materials according to the above weight components, and mixing and grinding the raw materials into fine powder;

[0062] (3) The ground fine powder is packaged separately, and the weight of each bag of Chinese medicine fine powder is 5-7g.

[0063] As a further explanation of the present invention, the weight of each bag of Chinese medicine fine powder in step (3) is 5 g.

[0064] The specific method of use of the present invention is as follows:

[0065] The patient takes 5g of fine Chinese medicine powder for oral administration each time, 2-3 times a day. The above-mentioned oral medicine can be taken before or after meals, without any toxic side effects. The above-mentioned medicine can enhance the activity and sensitivity of pancreatic cells, remove pancreatic resistance, and enhance the patient's physique. The above-mentioned oral medicine is not affected by the meal time after taking it. Mild patients can generally recover within 1-3 months.

[0066] Some of the treatment cases during use of the present invention are as follows:

[0067] Wang, female, age: 54, diagnosis: type 2 diabetes and dysuria, fasting blood sugar before diagnosis: 16.56, fasting blood sugar after diagnosis: 5.46, 2h postprandial blood sugar before diagnosis: 28.86, 2h postprandial blood sugar after diagnosis: 8.28. The treatment effect of her type 2 diabetes was significant, and after taking the above-mentioned oral medication for 3 months, the symptom of dysuria was well improved.

[0068] Zhang, male, age: 49, diagnosis: type 2 diabetes with tonsillitis and pain symptoms, fasting blood sugar before diagnosis: 9.67, fasting blood sugar after diagnosis: 8.16, 2h postprandial blood sugar before diagnosis: 16.28, 2h postprandial blood sugar after diagnosis: 8.48. The treatment effect of his type 2 diabetes was effective. After taking the above-mentioned oral medication for three months, the tonsillitis and pain symptoms were completely cured.

[0069] Liu, female, age: 12, diagnosis: type 2 diabetes with cold, spleen deficiency and poor appetite, fasting blood sugar before diagnosis: 14.42, fasting blood sugar after diagnosis: 5.29, 2h postprandial blood sugar before diagnosis: 19.61, 2h postprandial blood sugar after diagnosis: 10.22. The treatment effect of her type 2 diabetes was remarkable. After taking the above medicine for 2 months, the cold was cured and the symptoms of spleen deficiency and poor appetite were improved.

[0070] Test Example 1 Example 2 Clinical application of the oral Chinese medicine formula for treating type 2 diabetes.

[0071] A Chinese medicine formula for internal use for treating type 2 diabetes comprises the following components by weight: 30 parts of ginseng, 15 parts of astragalus, 15 parts of gecko, 15 parts of male silkworm moth, 15 parts of Liu Jinu, 5 parts of bupleurum, 10 parts of angelica dahurica, 6 parts of kudzu root, 15 parts of arctium, 6 parts of zelan, 15 parts of radix rehmanniae, 15 parts of euphorbia pulex, 15 parts of polygonatum, 15 parts of polygonatum and 30 parts of clematis.

[0072] From October 2018 to May 2022, 166 patients were screened in 5 hospitals, including 60 males and 106 females. Among them, 80 people were used as a treatment group, the treatment group took the oral medication of the present invention, and 86 people were used as a control group, the control group took metformin Western medicine to improve insulin resistance.

[0073] Selection criteria: patients who meet the symptoms of type 2 diabetes and have not used insulin for at least 10 days.

[0074] The therapeutic effects of the treatment group and the control group in Experimental Example 1 are shown in the following table:

[0075] Total patients get well Improvement invalid Adverse Reactions Efficiency Treatment Group 80 48 20 7 5 85％ Control group 86 50 10 8 18 69.76％

[0076] According to the above table, the effective rate of the oral Chinese medicine in Example 2 of the present invention in treating type 2 diabetes is significantly higher than the effective rate of the western medicine in the control group, and the above table shows that the adverse reaction cases of western medicine in treating type 2 diabetes are significantly higher than the adverse reaction cases of the oral Chinese medicine in the treatment group. Among them, long-term use of metformin western medicine can cause patients to experience nausea, vomiting, diarrhea, metallic taste in the mouth and other discomfort symptoms, and the above symptoms are all side effects of patients after taking metformin western medicine.

[0077] Test Example 2 Example 3 Clinical application of the oral Chinese medicine formula for treating type 2 diabetes.

[0078] A Chinese medicine formula for internal use for treating type II diabetes comprises the following components by weight: 35 parts of ginseng, 18 parts of astragalus, 18 parts of gecko, 18 parts of male silkworm moth, 18 parts of Liu Jinu, 6 parts of bupleurum, 11 parts of angelica root, 8 parts of kudzu root, 18 parts of arctium fruit, 8 parts of zelan, 18 parts of radix rehmanniae, 18 parts of euphorbia pulex, 18 parts of polygonatum, 18 parts of polygonatum and 35 parts of clematis.

[0079] From October 2018 to May 2022, 84 patients were screened in 5 hospitals, including 40 males and 44 females. Among them, 40 people were used as a treatment group, the treatment group took the oral medication of the present invention, and 44 people were used as a control group, the control group took the glitazone western medicine that improves insulin resistance.

[0080] The medication effects of the patients in the treatment group and the control group in Experimental Example 2 are shown in the following table:

[0081] Total patients get well Improvement invalid Adverse Reactions Efficiency Treatment Group 40 26 8 3 3 77.27％ Control group 44 22 6 4 12 63.6％

[0082] According to the above table, the effective rate of oral Chinese medicine in Example 3 of the present invention in treating type 2 diabetes is significantly higher than the effective rate of western medicine in the control group, and the above table shows that the adverse reaction cases of western medicine in treating type 2 diabetes are significantly higher than the adverse reaction cases of oral Chinese medicine in the treatment group. Among them, long-term use of glitazone western medicines to improve insulin resistance may cause symptoms such as sodium retention, weight gain, and heart failure, and the above symptoms are all side effects of long-term use of glitazone western medicines.

[0083] The present invention and its implementation methods are described above, and such description is not restrictive. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine formula for oral administration for treating type 2 diabetes, Features: The invention comprises the following components by weight: 20-40 parts of ginseng, 10-20 parts of astragalus, 10-20 parts of gecko, 10-20 parts of male silkworm moth, 10-20 parts of Liu Jinu, 4-8 parts of bupleurum, 6-12 parts of angelica root, 5-10 parts of kudzu root, 10-20 parts of stir-fried burdock fruit, 5-10 parts of zelan, 10-20 parts of radix rehmanniae, 10-20 parts of euphorbia pulex, 10-20 parts of polygonatum, 10-20 parts of polygonatum and 20-40 parts of gypsophila.

2. A Chinese medicine formula for treating type 2 diabetes according to claim 1, Features: The invention comprises the following components by weight: 20 parts of ginseng, 10 parts of astragalus, 10 parts of gecko, 10 parts of male silkworm moth, 10 parts of Liu Jinu, 4 parts of bupleurum, 6 parts of angelica root, 5 parts of kudzu root, 10 parts of stir-fried burdock fruit, 5 parts of zelan, 10 parts of radix rehmanniae, 10 parts of euphorbia pulex, 10 parts of polygonatum, 10 parts of polygonatum and 20 parts of clematis.

3. A Chinese medicine formula for treating type 2 diabetes according to claim 1, Features: The invention comprises the following components by weight, comprising the following components by weight, 30 parts of ginseng, 15 parts of astragalus, 15 parts of gecko, 15 parts of male silkworm moth, 15 parts of Liu Jinu, 5 parts of bupleurum, 10 parts of angelica root, 6 parts of kudzu root, 15 parts of stir-fried burdock fruit, 6 parts of zelan, 15 parts of radix rehmanniae, 15 parts of euphorbia pulex, 15 parts of polygonatum, 15 parts of polygonatum and 30 parts of clematis.

4. A Chinese medicine formula for oral administration for treating type 2 diabetes according to claim 1, Features: The invention comprises the following components by weight: 35 parts of ginseng, 18 parts of astragalus, 18 parts of gecko, 18 parts of male silkworm moth, 18 parts of Liu Jinu, 6 parts of bupleurum, 11 parts of angelica dahurica, 8 parts of kudzu root, 18 parts of stir-fried burdock fruit, 8 parts of zelan, 18 parts of radix rehmanniae, 18 parts of euphorbia pulex, 18 parts of polygonatum, 18 parts of polygonatum and 35 parts of clematis.

5. A Chinese medicine formula for oral administration for treating type 2 diabetes according to claim 1, Features: The invention comprises the following components by weight: 40 parts of ginseng, 20 parts of astragalus, 20 parts of gecko, 20 parts of male silkworm moth, 20 parts of Liu Jinu, 8 parts of bupleurum, 12 parts of angelica root, 10 parts of kudzu root, 20 parts of stir-fried burdock fruit, 10 parts of zelan, 20 parts of radix rehmanniae, 20 parts of euphorbia pulex, 20 parts of polygonatum, 20 parts of polygonatum and 40 parts of clematis.

6. A method for preparing a Chinese medicine formula for oral administration for treating type 2 diabetes according to claim 1, Features: The method comprises the following steps: (1) Stir-fried burdock seeds are prepared by mixing Momordica seeds and burdock seeds in a weight ratio of 1:

1. Momordica seeds are first fried until slightly yellow, and then burdock seeds are added and fried together. The burdock seeds are repeatedly fried and then the Momordica seeds are discarded. The fried burdock seeds are used as medicine; (2) preparing raw materials according to the above weight components, and mixing and grinding the raw materials into fine powder; (3) The ground fine powder is packaged separately, and the weight of each bag of Chinese medicine fine powder is 5-7g.

7. A method for preparing a Chinese medicine formula for oral administration for treating type 2 diabetes according to claim 6, Features: The weight of each bag of Chinese medicine fine powder in step (3) is 5g.