Full-automatic card type blood sample extraction equipment

Abstract

The invention discloses full-automatic card type blood sample extraction equipment. The full-automatic card type blood sample extraction equipment comprises an analysis module and a grabbing module, an outlet is formed in the bottom of the grabbing module, and an inlet communicated with the outlet is formed in the top of the analysis module; the grabbing module comprises an upper box body, a material box arranged in the upper box body and a grabbing mechanism; the analysis module comprises a lower box body, a bracket arranged in the lower box body, and a detection card conveying mechanism, a detection mechanism and an elution mechanism which are arranged on the bracket; the elution mechanism comprises a first sealing joint and a second sealing joint which are arranged front and back, a first flow channel is arranged in the first sealing joint, a first cavity communicated with the first flow channel is formed at the rear end of the first sealing joint, a second flow channel is arranged in the second sealing joint, a second cavity communicated with the second flow channel is formed at the front end of the second sealing joint, and an elution cavity is formed when the two cavities lean against each other. According to the invention, a blood sample on the detection card can be conveniently and rapidly eluted, and the detection cost is saved.

Description

Technical Field

[0001] The invention relates to the technical field of experimental instruments, and in particular to a fully automatic card-type blood sample extraction device. Background Art

[0002] Dried blood spot (DBS) is a mature and advanced method for blood collection and preservation. It is to drop blood from fingertips or heels on filter paper cards, dry them at room temperature for more than 2 hours to complete the preparation, and then store and transport them at room temperature. In recent years, dried blood spot technology has overcome the problems of high blood storage requirements and easy transformation of components, enhanced the stability of compounds in biological samples, and enabled blood samples to be stored and transported for a long time at room temperature. As a good alternative to liquid blood sample collection, DBS has been widely used in clinical fields such as clinical disease marker detection, drug monitoring, pharmacokinetic research, as well as metabolomics, doping screening and forensic identification. When performing DBS testing, existing testing equipment first needs to punch the blood sample spots on the card test paper, then add solvent to extract the sample, and after mixing and centrifugation to make a liquid sample, it is separated and analyzed by liquid chromatography-mass spectrometry. This process is cumbersome, the material cost is high, and it takes a long time. Summary of the invention

[0003] The object of the present invention is to provide a fully automatic card-type blood sample extraction device, which can conveniently and quickly elute the blood sample on the test card online and save the test cost.

[0004] The purpose of the present invention can be achieved through the following technical solutions:

[0005] A fully automatic card-type blood sample extraction device comprises an analysis module and a grabbing module arranged on the analysis module; an outlet is provided at the bottom of the grabbing module, and an inlet communicated with the outlet is provided at the top of the analysis module, and a detection card channel is formed between the outlet and the inlet; the grabbing module comprises an upper box body, a plurality of material boxes for storing detection cards arranged at the bottom position of the upper box body, and a grabbing mechanism for grabbing the detection card; the analysis module comprises a lower box body, a bracket arranged in the lower box body, a detection card transmission mechanism arranged on the bracket, a detection mechanism for detecting the position of the blood sample on the detection card, an elution mechanism for eluting the blood sample from the detection card with the blood sample that has arrived, and a detection card after the elution is completed. A drying system for drying; the elution mechanism includes a first tight joint and a second tight joint arranged at the front and rear, a gap is provided between the first tight joint and the second tight joint for the detection card to pass through, a tight joint driving motor is provided behind the second tight joint for driving the second tight joint to move toward the first tight joint, a first flow channel is provided in the first tight joint, a first cavity communicating with the first flow channel is formed at the rear end, a second flow channel is provided in the second tight joint, a second cavity communicating with the second flow channel is formed at the front end, wherein the first flow channel, the first cavity, the second flow channel and the second cavity are all coaxially arranged, the opening sizes of the two cavities are the same, and when the two cavities are close together, an elution cavity is formed.

[0006] With the above technical solution, during operation, the test card with the blood sample is transferred to the gap between the first and second tight joints, and the two cavities are close together to form an elution cavity, and the blood sample on the test card is just located in the elution cavity. Subsequently, the eluent flows into the second flow channel, passes through the elution cavity, and flows out of the first flow channel, so that the blood sample is separated from the test card, avoiding the need to punch holes in the prior art to remove the test paper containing the dry blood sample, dissolve it, centrifuge it, and make it into a liquid sample before the next step of analysis, thereby speeding up the detection process.

[0007] In a specific embodiment of the present invention: the volume of the first cavity is greater than the volume of the second cavity, the first cavity is conical, and the second cavity is flat. With this structure, since the second cavity is flat and has a small volume, the second cavity can be quickly filled with eluent, so that the eluent can fully contact the blood sample on the test card. The first cavity is conical and has a larger volume, so that a pressure difference is formed between it and the second cavity, promoting the penetration of the eluent, and at the same time enhancing the fluidity of the liquid that passes through the test card, so that the blood sample is easier to detach from the test card.

[0008] In a specific embodiment of the present invention: it also includes a heating element installed in the lower box body, the drying system, the heating element, the first tight joint and the second tight joint are connected through the same control pipeline, and a flow valve for controlling switching is also connected to the control pipeline.

[0009] In a specific embodiment of the present invention: an electric turntable is provided at the bottom of the upper box body, and a plurality of material boxes are evenly spaced on the electric turntable. The gripping mechanism includes a clamp, a clamp lifting assembly for driving the clamp to lift, a clamp longitudinal movement assembly for driving the clamp longitudinally, and a clamp transverse movement assembly for driving the clamp transversely.

[0010] In a specific embodiment of the present invention: the test card conveying mechanism includes a clamp located below the inlet, a clamp translation assembly driving the clamp to translate laterally, and a clamp lifting assembly driving the clamp to lift and lower.

[0011] In a specific implementation manner of the present invention: the clamp lifting assembly includes a U-shaped frame with a middle portion hinged on a bracket and a driving motor located at the rear portion of the U-shaped frame for driving the tail portion of the U-shaped frame to lift and lower.

[0012] In a specific embodiment of the present invention: the clamp translation assembly includes a support base fixed to the front end of the U-shaped frame, a motor fixed on the support base and a pulley, two pulleys are fixed at both ends of the support base, belts are sleeved on the two pulleys, one of the pulleys is connected to the motor through a rotating shaft, the clamp is fixedly connected to the belt, a plurality of guide wheels are provided on the support base, the belt passes around all the guide wheels in turn, the clamp is located at the front end of the U-shaped frame and is fixedly connected to the belt, a transverse guide rail is fixed on the support base in front of the belt, a transverse slider is slidably connected to the transverse guide rail, and the clamp is fixed on the transverse slider.

[0013] In a specific embodiment of the present invention: the elution mechanism further comprises an elution bracket, the first tight joint is installed on the elution bracket via a first connector, and the second tight joint is installed on the elution bracket via a second connector.

[0014] In a specific embodiment of the present invention: the first connecting member includes a first fixing block and a first clamping block, the first fixing block is fixed to the bottom surface of the elution bracket, the bottom surface of the first fixing block is provided with a transverse blind groove, the first clamping block is installed in the blind groove, the first clamping block is provided with a first clamping hole, and the first sealing joint is installed in the first clamping hole.

[0015] In a specific embodiment of the present invention: the second connecting member includes a second fixed block and a second clamping block, the second fixed block is fixed to the bottom surface of the elution bracket and is located on the rear side of the first fixed block, the bottom surface of the second fixed block is provided with a longitudinal slide groove, the second clamping block is slidably arranged in the slide groove, the second clamping block is provided with a second clamping hole, and the second sealing joint is installed in the second clamping hole.

[0016] In summary, in the present invention, a first flow channel is provided in the first tight joint, and a first cavity communicating with the first flow channel is formed at the rear end. A second flow channel is provided in the second tight joint, and a second cavity communicating with the second flow channel is formed at the front end, and an elution cavity is formed when the two cavities are close together. When the blood sample on the test card is just located in the elution cavity, the eluent flows into the second flow channel, passes through the elution cavity, and flows out of the first flow channel, so that the blood sample is quickly detached from the test card, thereby speeding up the elution process, and the structure is simple and cost-saving. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention will be further described below in conjunction with the accompanying drawings.

[0018] Figure 1 It is a structural schematic diagram of a fully automatic card-type blood sample extraction device of the present invention;

[0019] Figure 2 It is a structural schematic diagram of the analysis module of the present invention;

[0020] Figure 3 It is a structural schematic diagram of the grabbing mechanism of the present invention;

[0021] Figure 4 It is a structural schematic diagram of the upper box body of the present invention;

[0022] Figure 5 It is a structural schematic diagram of the analysis module of the present invention;

[0023] Figure 6 It is a structural schematic diagram of the detection card transmission mechanism of the present invention;

[0024] Figure 7 It is a structural schematic diagram of the elution mechanism of the present invention;

[0025] Figure 8 The test card is shown to be transferred to the gap between the first tight joint and the second tight joint;

[0026] Fig. 9 It is shown that when two cavities are close together, an elution cavity is formed, and the blood sample on the test card is just located in the elution cavity;

[0027] Fig.10 It is a structural schematic diagram of the first tight joint of the present invention;

[0028] Fig.11 It is a structural schematic diagram of the second tight joint of the present invention;

[0029] Fig.12 It is a schematic diagram of the structure of the detection card of the present invention;

[0030] Fig.13 is a schematic structural diagram of a first connecting member of the present invention;

[0031] Fig.14 It is a structural schematic diagram of the quick-change mechanism of the present invention;

[0032] Fig.15 is an exploded view of the first connecting member of the present invention;

[0033] Fig.16 is a schematic structural diagram of a second connecting member of the present invention;

[0034] Fig.17 is a flow chart showing the eluent. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] See also Figure 1 As shown, the present invention is a fully automatic card-type blood sample extraction device, comprising an analysis module 10 and a grabbing module 20 detachably arranged on the analysis module.

[0037] Combination Figure 2 As shown, the grabbing module 20 includes an upper box 21, a plurality of storage units arranged in the upper box 21, Fig.12 A material box 22 for the detection card 9 and a grabbing mechanism 23 for grabbing the detection card 9.

[0038] An electric turntable 24 is provided at the bottom of the upper box 21, and a plurality of material boxes 22 are evenly spaced on the electric turntable 24. In this embodiment, the number of material boxes 22 is four. An outlet 211 is provided at the bottom of the upper box 21 in front of the electric turntable 24. Among them, a plurality of compartments are evenly spaced in each material box 22, and a plurality of test cards 9 are inserted in the corresponding compartments. With the above technical solution, when all the test cards with blood samples in the current material box are eluted, the electric turntable 24 rotates to rotate the next box 22 to the bottom of the grabbing mechanism 23 to perform a new elution operation.

[0039] Combination Figure 3As shown, the gripping mechanism 23 includes a clamping jaw bracket 231 fixed in the upper box body 21, a clamping jaw longitudinal movement assembly 232 fixed on the clamping jaw bracket 231, a horizontal slide 233 installed on the output end of the clamping jaw longitudinal movement assembly 232, a clamping jaw transverse movement assembly 236 fixed on the horizontal slide 233, a clamping jaw lifting assembly 234 installed on the output end of the clamping jaw transverse movement assembly 236, a lifting slide 235 installed on the output end of the clamping jaw lifting assembly 234, and a clamping jaw 238 installed on the lifting slide 235 and driven to open and close by a clamping jaw cylinder 237.

[0040] In this embodiment, the clamping jaw lifting assembly 234, the clamping jaw longitudinal movement assembly 232 and the clamping jaw transverse movement assembly 236 are all linear modules driven by servo motors.

[0041] like Figure 4 and Figure 5 As shown, the analysis module 10 includes a lower box body 11, a bracket 17 arranged at the bottom of the lower box body 11, a test card conveying mechanism 12 arranged on the bracket 17, a detection mechanism 13 for detecting the position of the blood sample on the test card 9, and an elution mechanism 14 for eluting the blood sample from the arrived test card 9 with the blood sample using an elution liquid.

[0042] An inlet 111 communicating with the outlet 211 is provided at the top of the lower box body 11 , and a detection card channel is formed between the outlet 211 and the inlet 111 .

[0043] Combination Figure 6 As shown, the test card conveying mechanism 12 includes a clamp 121 located below the inlet 111, a clamp translation assembly 122 for driving the clamp to translate laterally, and a clamp lifting assembly 123 for driving the clamp to lift. The clamp 121 is used to receive the test card 9 output by the clamping claw 238.

[0044] The fixture lifting assembly 123 includes a U-shaped frame 1232 whose middle portion is hinged on the bracket 17 and a driving motor 1233 located at the rear of the U-shaped frame 1232 for driving the rear portion of the U-shaped frame 1232 to rise and fall.

[0045] The fixture translation assembly 122 includes a support seat 1221 fixed at the front end of a U-shaped frame 1232, a transverse motor 1222 fixed on the support seat 1221, and a pulley 1223. Two pulleys 1223 are fixed at both ends of the support seat 1221. Belts 1224 are sleeved on the two pulleys 1223, and one of the pulleys 1223 is connected to the motor 1222 through a rotating shaft. A plurality of guide wheels 1225 are provided on the support seat 1221, and the belt 1224 passes through all the guide wheels 1225 in sequence. The fixture 121 is located at the front end of the U-shaped frame and is fixedly connected to the belt 1224. A transverse guide rail 1226 is fixed on the support seat 1221 in front of the belt 1224, and a transverse slider 1227 is slidably connected on the transverse guide rail 1226, and the fixture 121 is fixed on the transverse slider 1227. When the fixture 121 is driven to move transversely, it has a first stop position and a second stop position. When the clamp 121 is located directly below the inlet 111, it is the first stop position, and when the clamp 121 is located at the elution mechanism, it is the second stop position.

[0046] In addition, vertical guide rails 15 are respectively arranged at both sides of the support seat 1221 at the bottom of the bracket 17, and vertical sliders 16 are slidably connected to the vertical guide rails 15. The two ends of the support seat 1221 are fixedly connected to the corresponding vertical sliders 16 respectively.

[0047] A first sensor 124 is provided near the tail of the U-shaped frame 1232. A second sensor 125 and a third sensor 126 are respectively installed on the inner side surfaces of the left and right sides of the support seat 1221. All sensors are electrically connected to a controller (not shown). When the fixture 121 is located at the first stop position, the third sensor 126 detects the fixture 121, and transmits a signal to the controller, and the controller controls the drive motor 1233 to start, driving the tail of the U-shaped frame 1232 to descend. When the first sensor 124 detects the tail of the U-shaped frame 1232 (i.e., the tail of the U-shaped frame 1232 is in a low position, and the front end of the U-shaped frame 1232 is in a high position after rising), the drive motor 1233 stops, and then the controller controls the jaws 238 to descend and insert the detection card 9 into the fixture 121. Subsequently, the controller controls the drive motor 1233 to drive the tail of the U-shaped frame 1232 to rise slightly, so that the front end of the U-shaped frame 1232 is slightly lowered, and the fixture 121 is driven to descend slightly. Afterwards, the transverse motor 1222 is started and drives the clamp 121 to move to the second stop position. The second sensor 125 detects the clamp 121 and transmits a signal to the controller. The controller controls the transverse motor 1222 to stop, and then performs the next action.

[0048] The detection mechanism 13 includes a camera light source 131 located behind the first stop position and a detection camera 132 located behind the camera light source 131. The detection camera 132 and the camera light source 131 are both electrically connected to the controller.

[0049] Combination Figure 7 and Figure 8 As shown, the elution mechanism 14 includes an elution support 141, a first tight joint 142 and a second tight joint 143 installed in front and rear of the elution support 141. There is a gap between the first tight joint 142 and the second tight joint 143 for the detection card 9 to pass through.

[0050] like Figure 7 , Fig.13 and Fig.16 As shown, the first tight joint 142 is installed on the elution support 141 through the first connection member 40 , and the second tight joint 143 is installed on the elution support 141 through the second connection member 50 .

[0051] like Fig.13 , Fig.14 and Fig.15 As shown, the first connecting member 40 includes a first fixing block 41 and a first clamping block 42. The first fixing block 41 is fixed to the bottom surface of the elution bracket 141. The first clamping block 42 is installed on the bottom surface of the first fixing block 41. A transverse blind groove 46 is provided on the bottom surface of the first fixing block 41. The blind groove 46 is a structure with one end open and one end closed. In this way, when the first clamping block 42 is installed in the blind groove 46, the inner end of the first clamping block 42 is stopped by the closed end of the blind groove 46. A first clamping hole 44 is provided in the middle of the first clamping block 42. A first slit 442 is provided below the first clamping hole 44 and communicates with the first clamping hole 44. A first bolt hole 445 is provided at the lower part of the first clamping block 42 and passes through the first slit 442. A first locking bolt 446 is provided in the first bolt hole 445. During assembly, the first tight joint 142 is inserted into the first clamping hole 44, and the first locking bolt 446 is tightened, so that the first tight joint 142 is locked and fixed.

[0052] like Fig.14 and Fig.15 As shown, a quick-change mechanism 60 for conveniently replacing the first clamping block 42 is provided at the open end of the blind groove 46 .

[0053] The quick-change mechanism 60 includes a pressing block 61, a stop block 62 and a pin 63. An integrally formed mounting seat 64 is provided on the front side surface of the first fixed block 41 near the opening end of the blind groove 46. The mounting seat has a transverse groove 641 and a horizontally arranged sliding hole 642 that penetrates the transverse groove 641. The sliding hole 642 is in communication with the blind groove 46. The transverse groove 641 is a stepped groove with a step at the bottom. The pressing block 61 is inserted into the transverse groove 641, and there is a gap between the inner end surface of the horizontal portion 611 of the pressing block 61 and the side wall surface opposite to the notch of the transverse groove 641. The lower horizontal portion 611 of the pressing block 61 contacts the step. The stop block 62 is inserted into the sliding hole 642 and is located between the two horizontal portions 611 of the pressing block 61. A waist-shaped hole 621 is provided on the stop block 62. The waist-shaped hole 621 has a first position 622 and a second position 623. The two horizontal parts 611 of the pressing block 61 are symmetrically provided with pin holes 612. The pin 63 is located in the waist-shaped hole 621, and after the upper and lower ends respectively penetrate the corresponding pin holes 612, the lower end is stopped by the step at the bottom of the transverse groove 641.

[0054] When the pin 63 is located at the first position of the waist-shaped hole 621, the inner end of the stop block 62 extends into the blind groove 46 to abut against the end of the first clamping block, and the outer end is located in the sliding hole 642; when the pressing block 61 is pressed, the pressing block 61 moves to force the pin 63 to move from the first position 622 to the second position 623, the outer end of the stop block 62 extends out of the sliding hole 642, and the inner end retracts into the sliding hole 642, and the inner end of the stop block 62 does not contact the first clamping block 42 and does not stop the first clamping block 42, so that the first clamping block 42 can be removed from the open end of the blind groove 46. With this structure, not only can the first tight joint 142 be removed quickly and conveniently, but also sufficient space can be left when replacing the second tight joint 143, so that the second tight joint 143 can be replaced easily.

[0055] like Figure 7 and Fig.16 As shown, the second connecting member 50 includes a second fixing block 51 and a second clamping block 52. The second fixing block 51 is fixed to the bottom surface of the elution bracket 141. A longitudinal slide groove 55 is provided on the bottom surface of the second fixing block 51. The second clamping block 52 is slidably arranged in the longitudinal slide groove 55. A second clamping hole 53 is provided in the middle position of the second clamping block 52. A second slit 532 communicating with the second clamping hole 53 is provided below the second clamping hole 53. A second bolt hole 533 penetrating the second slit 532 is provided at the lower part of the second clamping block 52, and a second locking bolt 534 is provided in the second bolt hole 533. During assembly, the second tight joint 143 is installed in the second clamping hole 53, and the second locking bolt 534 is tightened, so that the second tight joint 143 is locked and fixed.

[0056] A sealing joint driving motor 144 is fixed on the elution support 141 to drive the second sealing joint 143 to move toward the first sealing joint 142 .

[0057] Combination Fig. 9 , Fig.10 and Fig.11 As shown, a first flow channel 145 is provided in the first sealing joint 142, and a first cavity 1451 communicating with the first flow channel 145 is formed at the rear end. A second flow channel 146 is provided in the second sealing joint 143, and a second cavity 1461 communicating with the second flow channel 146 is formed at the front end. Among them, the first flow channel 145, the first cavity 1451, the second flow channel 146 and the second cavity 1461 are all coaxially arranged. The openings of the two cavities are the same size, and an elution cavity 147 is formed when the two cavities are close together. With the above structure, the test card with the blood sample is transferred to the gap between the first sealing joint 142 and the second sealing joint 143, and an elution cavity 147 is formed when the two cavities are close together, and the blood sample on the test card is just located in the elution cavity 147. Subsequently, the eluent flows into the second flow channel, passes through the elution chamber, and flows out of the first flow channel, so that the blood sample is separated from the test card, avoiding the need in the prior art to first punch out the blood sample spot on the card test paper, then add a solvent to extract the sample, and after mixing and centrifugation to make a liquid sample, separate and analyze it through liquid chromatography-mass spectrometry, thereby greatly speeding up the detection process.

[0058] In this embodiment, the volume of the first cavity 1451 is greater than the volume of the second cavity 1461. The first cavity 1451 is conical, and the second cavity 1461 is flat. With this structure, since the second cavity is flat and has a small volume, the second cavity can be quickly filled with eluent, so that the eluent and the blood sample can fully contact each other. The first cavity is conical and has a larger volume, so that a pressure difference is formed between it and the first cavity, promoting the penetration of the eluent, and at the same time enhancing the fluidity of the liquid that passes through the test card, so that the blood sample is easier to detach from the test card.

[0059] like Fig. 9 , Fig.10 and Fig.11 As shown, an annular boss 147 is provided on the front end face of the second tight joint 143. An annular recess 148 matching with the boss 147 is provided on the rear end face of the first tight joint 142. With this structure, the detection card 9 can be clamped more tightly and the sealing effect is good.

[0060] like Fig.17As shown, a drying system 30 and a heating element 32 are also installed on the bottom plate 171. A delivery pump 7, a detection instrument 6 and a collection bottle 5 are also provided on the outside of the lower box 11. The delivery pump 7, the drying system 30, the heating element 32, the first tight joint 142, the second tight joint 143, the detection instrument 6 and the collection bottle are all connected to a control pipeline 8. In this way, the eluent is pneumatically delivered by the delivery pump 7, and the eluent enters the elution chamber from the second flow channel to elute the blood sample on the detection card 9. After that, it flows out from the first flow channel, and the eluent with the blood sample will enter the detection instrument 6 for detection. Subsequently, the waste liquid is switched by the switching valve 4 connected to the control pipeline 8 and flows into the collection bottle 5. A circulation valve 31 is also provided on the control pipeline 8, and the switching of the gas circuit or the water circuit is controlled by the circulation valve 31. The heating element is used to heat the part of the control pipeline located at the rear side of the second flow channel, thereby heating the eluent flowing through, so that it is easier for the eluent to elute the blood sample on the test card. After the elution of the blood sample on the test card is completed, the hot air generated by the drying system 30 is used to control the switching through the circulation valve 31. The hot air is blown into the second flow channel 145, through the elution chamber 147, and blown out from the first flow channel 146 to enter the collection bottle 5. The hot air dries the current test card 9 to prevent too much eluent from being left on the test card so that the test card can be recycled. At the same time, the control pipeline can also be dried and the residual eluent can be emptied.

[0061] The above is the fully automatic card-type blood sample extraction device of the present invention, and its working method is as follows: during operation, the rotary motor drives the electric turntable 24 to rotate, and a material box 22 is transferred to the bottom of the grasping mechanism 23 as the current material box 22. Subsequently, the clamp lifting assembly 234, the clamp longitudinal movement assembly 232, the clamp transverse movement assembly 236 and the clamp cylinder 237 cooperate with each other to drive the clamp 238 to clamp the frontmost test card 9 with the blood sample in the material box 22. At this time, the clamp 121 waiting at the first stop position is detected by the third sensor 126, and the signal is transmitted to the controller. Subsequently, the controller controls the drive motor 1233 to start and drive the tail of the U-shaped frame 1232 to descend. When the first sensor 124 detects the tail of the U-shaped frame 1232, the tail of the U-shaped frame 1232 is in a low position, and the front end of the U-shaped frame 1232 is in a high position after rising, and the drive motor 1233 stops. Subsequently, the controller controls the jaw lifting assembly 234, the jaw longitudinal movement assembly 232 and the jaw transverse movement assembly 236 to cooperate with each other to insert the current detection card 9 from the outlet 211 and through the inlet 111 into the fixture 121. At the same time, the jaw cylinder 237 drives the jaw 238 to release the current detection card 9.

[0062] Subsequently, the driving motor 1233 drives the tail of the U-shaped frame 1232 to rise slightly, so that the front end of the U-shaped frame 1232 drops slightly. After that, the detection camera 132 scans the current detection card 9. The detection camera 132 transmits the taken photo to the controller, and after the controller intelligently identifies the position of the blood sample on the detection card 9 in the photo, the controller controls the clamp lifting assembly 123 and the clamp translation assembly 122 to cooperate, and drives the clamp 121 to clamp the current detection card 9 and move it to the gap between the first tight joint 142 and the second tight joint 143, and the blood sample on the detection card 9 is just located between the first cavity 1451 and the second cavity 1461. Subsequently, the tight joint driving motor 144 drives the second tight joint 143 to translate toward the first tight joint 142 until it abuts against the first tight joint 142, and the two cavities are close together to form an elution cavity 147. Subsequently, through the pneumatic delivery of the delivery pump, the eluent flows in from the second flow channel 146, passes through the elution chamber 147, and flows out from the first flow channel 145, the blood sample is separated from the test card, and the eluent with the blood sample flows into the detection instrument for detection, and then the switching valve 4 is switched to make the waste liquid flow into the collection bottle 5. After that, the circulation valve 31 controls the switching, and the hot air generated by the drying system is blown into the second flow channel 146, passes through the elution chamber 147, and blows out from the first flow channel 145 into the collection bottle, drying the current test card 9, and drying the control pipeline at the same time, and emptying the residual eluent.

[0063] Subsequently, the seal joint driving motor 144 drives the second seal joint 143 to return to the initial position, and the clamp lifting assembly 123 and the clamp translation assembly 122 cooperate to drive the clamp 121 to clamp the current test card 9 and move it below the inlet 111. Subsequently, the clamp lifting assembly 234, the clamp longitudinal movement assembly 232, the clamp transverse movement assembly 236 and the clamp cylinder 237 cooperate with each other to drive the clamp 238 to clamp the current test card 9 and put it back into the original compartment 221 of the material box 22. Subsequently, the next test card 9 with a blood sample is grabbed in turn and the above steps are repeated. In this cycle, the continuous elution operation of the test cards 9 with blood samples is realized one by one.

[0064] In summary, in the present invention, a first flow channel is provided in the first tight joint, and a first cavity communicating with the first flow channel is formed at the rear end. A second flow channel is provided in the second tight joint, and a second cavity communicating with the second flow channel is formed at the front end, and an elution cavity is formed when the two cavities are close together. When the blood sample on the test card is located in the elution cavity, the eluent flows into the second flow channel, passes through the elution cavity, and flows out of the first flow channel, so that the blood sample is quickly detached from the test card, thereby speeding up the detection process, and the structure is simple and cost-saving.

[0065] The above is a detailed description of an embodiment of the present invention, but the content is only a preferred embodiment of the present invention and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. A fully automatic card-type blood sample extraction device, comprising an analysis module and a grabbing module arranged on the analysis module; an outlet is provided at the bottom of the grabbing module, an inlet is provided at the top of the analysis module and communicates with the outlet, and a detection card channel is formed between the outlet and the inlet; characterized in that: The grabbing module includes an upper box, a plurality of material boxes for storing test cards arranged at the bottom of the upper box, and a grabbing mechanism for grabbing the test cards; the analysis module includes a lower box, a bracket arranged in the lower box, a test card conveying mechanism arranged on the bracket, a detection mechanism for detecting the position of the blood sample on the test card, an elution mechanism for eluting the blood sample from the test card with the blood sample, and a drying system for drying the test card after elution; the elution mechanism includes a first sealing joint and a second sealing joint arranged at the front and rear, and the first sealing joint is provided at the back. There is a gap between the joint and the second tight joint for the detection card to pass through, and a tight joint driving motor is provided behind the second tight joint to drive the second tight joint to move toward the first tight joint, a first flow channel is provided in the first tight joint, and a first cavity communicating with the first flow channel is formed at the rear end, and a second flow channel is provided in the second tight joint, and a second cavity communicating with the second flow channel is formed at the front end, wherein the first flow channel, the first cavity, the second flow channel and the second cavity are all coaxially arranged, and the opening sizes of the two cavities are the same, and when the two cavities are close together, an elution cavity is formed.

2. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: The volume of the first cavity is greater than that of the second cavity, the first cavity is conical, and the second cavity is flat.

3. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: It also includes a heating element installed in the lower box body. The drying system, the heating element, the first tight joint and the second tight joint are connected through the same control pipeline, and a flow valve for controlling switching is also connected to the control pipeline.

4. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: An electric turntable is provided at the bottom of the upper box body, and multiple material boxes are evenly spaced on the electric turntable. The gripping mechanism includes a jaw, a jaw lifting assembly for driving the jaw to lift and lower, a jaw longitudinal movement assembly for driving the jaw to translate longitudinally, and a jaw transverse movement assembly for driving the jaw to translate transversely.

5. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: The detection card conveying mechanism comprises a clamp located below the inlet, a clamp translation assembly driving the clamp to translate laterally, and a clamp lifting assembly driving the clamp to lift and lower.

6. The fully automatic card-type blood sample extraction device according to claim 5, characterized in that: The clamp lifting assembly comprises a U-shaped frame with a middle portion hinged on a bracket and a driving motor located at the rear portion of the U-shaped frame for driving the tail portion of the U-shaped frame to lift and lower.

7. The fully automatic card-type blood sample extraction device according to claim 5, characterized in that: The clamp translation assembly includes a support base fixed to the front end of the U-shaped frame, a motor fixed to the support base and a pulley, two pulleys are fixed at both ends of the support base, belts are sleeved on the two pulleys, one of the pulleys is connected to the motor through a rotating shaft, the clamp is fixedly connected to the belt, a plurality of guide wheels are provided on the support base, the belt passes around all the guide wheels in turn, the clamp is located at the front end of the U-shaped frame and is fixedly connected to the belt, a transverse guide rail is fixed on the support base in front of the belt, a transverse slider is slidably connected to the transverse guide rail, and the clamp is fixed on the transverse slider.

8. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: The elution mechanism also includes an elution bracket, the first tight joint is installed on the elution bracket through a first connecting member, and the second tight joint is installed on the elution bracket through a second connecting member.

9. The fully automatic card-type blood sample extraction device according to claim 8, characterized in that: The first connecting member includes a first fixing block and a first clamping block. The first fixing block is fixed to the bottom surface of the elution bracket. The bottom surface of the first fixing block is provided with a transverse blind groove. The first clamping block is installed in the blind groove. The first clamping block is provided with a first clamping hole. The first sealing joint is installed in the first clamping hole.

10. The fully automatic card-type blood sample extraction device according to claim 8, characterized in that: The second connecting member includes a second fixed block and a second clamping block. The second fixed block is fixed to the bottom surface of the elution bracket and is located behind the first fixed block. The bottom surface of the second fixed block is provided with a longitudinal slide groove. The second clamping block is slidably arranged in the slide groove. The second clamping block is provided with a second clamping hole. The second sealing joint is installed in the second clamping hole.

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