Liver oxygen-carrying mechanical perfusion device

Abstract

The invention relates to the technical field of organ preservation equipment, in particular to a liver oxygen-carrying mechanical perfusion device which comprises a mounting table arranged at the top of a base; the placing sleeve used for placing the storage assembly is arranged on the left side of the mounting table in an embedded mode; and the preservation assembly is used for storing the in-vitro liver. An in-vitro liver is placed on an elastic film of a placing disc in a storage cabin, then organ keeping liquid is injected, two specially-made connecting pipes are connected with a tendon vessel blood vessel and an artery blood vessel of the in-vitro liver respectively, the other ends of the two connecting pipes are connected into one end, located in a cabin cover, of a pipeline connector respectively, then the cabin cover and the storage cabin are screwed and tightly closed, and the in-vitro liver is stored in the storage cabin. The activity maintenance liquid in the preservation box passes through the hard conveying pipe, the soft conveying pipe and the pipeline connector through the pump body to form circulation with the in-vitro liver, and then the in-vitro liver is protected.

Description

Technical Field

[0001] The present invention relates to the technical field of organ preservation equipment, and in particular to a liver oxygen-carrying mechanical perfusion device. Background Art

[0002] Liver transplantation is the only solution to end-stage liver disease, but the imbalance between supply and demand of transplanted organs is a long-standing problem worldwide. Donation is currently the only legal source of organs in China. Organs donated in remote areas may have to be abandoned due to long transportation times. Donated livers may also be wasted in large quantities due to improper ex vivo preservation methods and unqualified organs. Therefore, extending the preservation time of organs and improving their preservation quality are effective ways to solve the organ shortage.

[0003] The preservation method of ex vivo liver is particularly important. Since the natural physiological state in vitro is very different from that in vivo, improper preservation of ex vivo liver can lead to ischemia and hypoxia, causing partial necrosis of organ tissues. The various existing liver mechanical perfusion preservation devices are relatively large and inconvenient for short-distance preservation.

[0004] Therefore, a liver oxygen-carrying mechanical perfusion device is designed to facilitate keeping the organ alive and maintaining a high level of organ function, so as to solve the problem of ischemic hypoxic necrosis of the isolated liver during the perfusion preservation process, thereby leading to transplantation failure or decreased survival rate of patients in the later stage. Summary of the invention

[0005] In order to overcome the disadvantage that local ischemic hypoxic necrosis of the isolated liver occurs during the perfusion preservation process, which leads to transplantation failure or a decrease in the survival rate of patients in the later stage, the technical problem to be solved is: to provide a liver oxygen-carrying mechanical perfusion device that is convenient for keeping the organ alive and maintaining a high level of organ function.

[0006] The technical scheme is: a liver oxygen-carrying mechanical perfusion device, comprising a base, a mounting platform, a mounting platform is arranged on the top of the base; a placement sleeve, a placement sleeve for placing a preservation component is embedded on the left side of the mounting platform; a preservation component, the preservation component is used to store an ex vivo liver; a temporary circulation component, a temporary circulation component for injecting an ex vivo liver into the artery and vein to maintain the circulation of active maintenance fluid is arranged on the preservation component; a fixing component, a fixing component for fixing the preservation component on the outside of the preservation component is arranged on the placement sleeve; a limiting frame, a limiting frame is arranged on the middle side of the top of the base; a preservation box, a preservation box for storing active maintenance fluid is arranged in the limiting frame, and the preservation box has a constant temperature heating function; a hard delivery tube, two hard delivery tubes are arranged through the preservation box, the hard delivery tubes are arranged through the mounting platform, and one of the hard delivery tubes is connected to a pump body; a drug introducer, a drug introducer is arranged on the mounting platform, and the drug introducer is connected to one of the hard delivery tubes; a soft delivery tube, two hard delivery tubes are connected to the ends of the hard delivery tubes.

[0007] In one of the embodiments, the preservation component includes: a preservation chamber, on which a hatch cover is screwed; a temperature detector, on which a temperature detector is embedded; a liquid inlet, two liquid inlets are arranged at the lower part of the preservation chamber; and a valve, on which valves are arranged.

[0008] In one of the embodiments, the temporary circulation component includes: a mounting plate, a mounting plate is embedded on the hatch cover; a pipe joint, two pipe joints are embedded on the mounting plate; a bracket, a bracket is provided on one side of the upper part of the hatch cover; a storage tank, a storage tank is screwed on the bracket; a connector, a connector is connected to the bottom of the storage tank through a hose, and the connector is connected to the pipe joint; an exchange pump, an exchange pump is provided at the bottom of the bracket, and the water inlet of the exchange pump is connected to the storage tank; a water outlet of the exchange pump is connected to a connector through a hose.

[0009] In one embodiment, the liver oxygen-carrying mechanical perfusion device includes a fixing assembly, which includes: a fixing block, a fixing block is provided at the lower part of the side wall of the storage chamber; an arc-shaped clamping shaft, an arc-shaped clamping shaft is provided on the fixing block; an annular placement rack, an annular placement rack is provided on the lower inner side of the placement sleeve; an arc-shaped clamping sleeve, an arc-shaped clamping sleeve is provided on the side wall of the placement sleeve, and the arc-shaped clamping shaft cooperates with the placement sleeve.

[0010] In one of the embodiments, a placement component is also included, which includes a cylindrical cylinder body, which is embedded in the bottom of the storage cabin; a piston, which is slidably arranged in the cylindrical cylinder body; a connecting column, which is arranged at the center of the top of the piston; a placement plate, which is arranged on the top of the connecting column; and an elastic membrane, which is arranged in the placement plate.

[0011] In one of the embodiments, the liver oxygen carrying mechanical perfusion device includes an adjustment component, which includes: a guide column, which is symmetrically arranged at the bottom of a sleeve; a disc, on which two guide columns are slidably arranged; a bearing seat, which is symmetrically arranged at the bottom of the sleeve; a crankshaft, which is rotatably arranged between the two bearing seats, and the crankshaft is located between the two guide columns; a motor, which is arranged at the bottom of the sleeve, and the output shaft of the motor is connected to one end of the crankshaft through a coupling; a sleeve, which is sleeved on the bent portion of the crankshaft, and the sleeve is slidably matched with the straight groove at the bottom of the disc; a clamping plate, which is provided with a clamping hole at the center of the bottom of the storage cabin, a clamping plate is provided at the bottom of the piston, and a clamping slot is provided at the top of the disc, the slot width in the middle of the clamping slot is greater than the slot width at the top, and square slots are symmetrically opened on the disc, the square slots are connected to the clamping slot, and the clamping plate matches the clamping slot.

[0012] In one of the embodiments, it also includes a liquid storage tank, which is arranged on the right side of the top of the base to store the organ retention fluid, and a constant temperature heater is arranged in the liquid storage tank; a peristaltic pump, which is arranged on the right side of the top of the mounting table, and the liquid inlet of the peristaltic pump is connected to the liquid storage tank through a hose; a filter, the peristaltic pump, and the liquid outlet is connected to the filter; a pipeline, the filter is connected to the liquid inlet through the pipeline, and the other liquid inlet of the preservation cabin is connected to the liquid storage tank through the pipeline.

[0013] In one of the embodiments, it further includes: a stirrer, and the storage box is provided with a stirrer for stirring the internal liquid.

[0014] In one embodiment, the preset temperature in the preservation box is 33-37°C.

[0015] The present invention has the following advantages: 1. The isolated liver is placed on the elastic membrane of the tray placed in the preservation chamber, and then the organ preservation liquid is injected, and the two specially made connecting tubes are respectively connected to the tendons and blood vessels and arteries of the isolated liver, and the other ends of the two connecting tubes are respectively connected to one end of the pipeline joint located inside the cabin cover, and then the cabin cover and the preservation chamber are screwed and closed, and the active maintenance liquid in the preservation box is circulated with the isolated liver through the pump body, the hard delivery tube, the soft delivery tube, and the pipeline joint, thereby protecting the isolated liver. According to the situation, drugs such as heparin, glucose, physiological saline, adrenaline, etc. can be added through the drug introducer; red blood cells, artificial blood (such as HBOC) and other oxygen-carrying agents can also be added through the liver inlet pipeline 2.

[0016] 2. When temporary transport of ex vivo liver is required, turn the rotating storage chamber 90° in the opposite direction, turn the card plate to the disc square groove position, and separate the arc card shaft from the arc card sleeve. Then pull out the soft delivery tube, connect the connector of the temporary circulation component to the pipe joint, start the exchange pump, realize the temporary reflux of the active maintenance fluid, and then maintain the perfusion of the liver during the temporary transport process to prevent the expansion of the hepatic sinus and the accumulation of the perfused active maintenance fluid. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention.

[0018] Figure 2 It is a three-dimensional structural schematic diagram of the storage component of the present invention.

[0019] Figure 3 It is a schematic diagram of the expanded structure of the storage component of the present invention.

[0020] Figure 4 It is a schematic diagram of the installation structure for placing components of the present invention.

[0021] Figure 5 It is a three-dimensional structural schematic diagram of placing components of the present invention.

[0022] Figure 6 This is a schematic diagram of the installation structure of the adjustment component of the present invention.

[0023] Figure 7 It is a schematic diagram of the three-dimensional structure of the adjustment component of the present invention.

[0024] The markings in the figure are: 1. Base, 2. Mounting table, 3. Placement sleeve, 4. Storage component, 41. Storage cabin, 42. Hatch cover, 43. Temperature detector, 44. Liquid inlet, 45. Valve, 5. Temporary circulation component, 51. Mounting plate, 52. Pipe joint, 53. Bracket, 54. Storage tank, 55. Connector, 56. Exchange pump, 6. Fixing component, 61. Fixing block, 62. Arc clamp shaft, 63. Ring placement rack, 64. Arc clamp, 7. Limit frame, 8. Storage box, 9. Hard conveyor Tube, 91, drug introducer, 10, soft delivery tube, 11, placement component, 111, cylindrical cylinder, 112, piston, 113, connecting column, 114, placement plate, 115, elastic membrane, 12, adjustment component, 121, guide column, 122, disc, 123, bearing seat, 124, crankshaft, 125, motor, 126, bushing, 127, card hole, 128, card slot, 129, card plate, 13, pipeline, 14, liquid storage tank, 15, peristaltic pump, 16, filter, 17, agitator. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings. It should be understood that these descriptions are only exemplary and are not intended to limit the scope of the present invention. In addition, in the following description, the description of well-known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0026] Example 1: Figure 1-7As shown, a liver oxygen-carrying mechanical perfusion device includes a base 1, a mounting platform 2, a placement sleeve 3, a preservation component 4, a temporary circulation component 5, a fixing component 6, a limit frame 7, a preservation box 8, a hard delivery tube 9, a drug introducer 91 and a soft delivery tube 10. The top of the base 1 is provided with a mounting platform 2, and a placement sleeve 3 for placing the preservation component 4 is embedded on the left side of the mounting platform 2. The preservation component 4 consists of a preservation cabin 41, a cabin cover 42, a temperature detector 43, a liquid inlet 44 and a valve 45. The cabin cover 42 is screwed on the preservation cabin 41, and the cabin cover 42 is embedded with a temperature detector 43. Two liquid inlets 44 are provided at the lower part of the preservation cabin 41, and valves 45 are provided on the liquid inlets 44. Component 4 is used to store an ex vivo liver. A temporary circulation component 5 is provided on the preservation component 4 for injecting an active maintenance fluid into the arteries and veins of the ex vivo liver for circulation. A fixing component 6 for fixing it on the outer side of the preservation component 4 is provided on the sleeve 3. A limiting frame 7 is provided on the middle side of the top of the base 1. A preservation box 8 for storing the active maintenance fluid is provided in the limiting frame 7. The preservation box 8 has a constant temperature heating function. Two hard delivery tubes 9 are provided through the preservation box 8. The hard delivery tubes 9 are provided through the mounting platform 2. One of the hard delivery tubes 9 is connected to a pump body. A drug introducer 91 is provided on the mounting platform 2. The drug introducer 91 is connected to one of the hard delivery tubes 9. The ends of the two hard delivery tubes 9 are connected to soft delivery tubes 10.

[0027] like Figure 1-3 As shown, the temporary circulation component 5 includes a mounting plate 51, a pipe joint 52, a bracket 53, a storage tank 54, a connector 55 and an exchange pump 56. The hatch cover 42 is embedded with the mounting plate 51, and two pipe joints 52 are embedded on the mounting plate 51. The pipe joints 52 are provided with connecting threads. A bracket 53 is provided on one side of the upper part of the hatch cover 42, and a storage tank 54 is screwed on the bracket 53. The bottom of the storage tank 54 is connected to a connector 55 through a hose, and the connector 55 is connected to the pipe joint 52. An exchange pump 56 is provided at the bottom of the bracket 53, and the water inlet of the exchange pump 56 is connected to the storage tank 54, and the water outlet of the exchange pump 56 is connected to a connector 55 through a hose.

[0028] like Figure 2-3 As shown, the fixing assembly 6 includes a fixing block 61, an arc-shaped clamping shaft 62, an annular placement rack 63 and an arc-shaped clamping sleeve 64. The fixing block 61 is arranged on the lower part of the side wall of the storage chamber 41, and the arc-shaped clamping shaft 62 is arranged on the fixing block 61. The annular placement rack 63 is fixedly connected to the lower inner side of the placement sleeve 3, and the arc-shaped clamping sleeve 64 is arranged on the side wall of the placement sleeve 3. The center of the arc-shaped clamping sleeve 64 coincides with the arc-shaped clamping shaft 62, and the arc-shaped clamping shaft 62 cooperates with the placement sleeve 3.

[0029] like Figure 4-5As shown, it also includes a placement component 11, which includes a cylindrical cylinder body 111, a piston 112, a connecting column 113, a placement plate 114 and an elastic membrane 115. The cylindrical cylinder body 111 is embedded at the bottom of the storage cabin 41, the piston 112 is slidably arranged in the cylindrical cylinder body 111, a connecting column 113 is arranged at the top center of the piston 112, a placement plate 114 is arranged on the top of the connecting column 113, and an elastic membrane 115 is arranged in the placement plate 114.

[0030] like Figure 6-7 As shown, the adjustment assembly 12 includes a guide column 121, a disc 122, a bearing seat 123, a crankshaft 124, a motor 125, a sleeve 126 and a clamping plate 129. The guide columns 121 are symmetrically arranged at the bottom of the placement sleeve 3. The discs 122 are slidably arranged on the two guide columns 121. The bearing seats 123 are symmetrically arranged at the bottom of the placement sleeve 3. The crankshaft 124 is rotatably arranged between the two bearing seats 123. The crankshaft 124 is located between the two guide columns 121. The motor 125 is arranged at the bottom of the placement sleeve 3. The output shaft of the machine 125 is connected to one end of the crankshaft 124 through a coupling. The bent portion of the crankshaft 124 is sleeved with a shaft sleeve 126. The shaft sleeve 126 is slidably matched with the straight groove at the bottom of the disc 122. A clamping hole 127 is provided at the center of the bottom of the storage cabin 41. A clamping plate 129 is provided at the bottom of the piston 112. A clamping groove 128 is provided at the top of the disc 122. The groove width in the middle of the clamping groove 128 is greater than the groove width at the top. Square grooves are symmetrically opened on the disc 122. The square grooves are connected with the clamping groove 128, and the clamping plate 129 is matched with the clamping groove 128.

[0031] When the device is needed, the staff will place the ex vivo liver on the elastic membrane 115 of the placement disk 114 in the preservation chamber 41, and then inject the organ preservation liquid. Through two specially made connecting tubes, the tendons and arteries of the ex vivo liver are connected respectively, and the other ends of the two connecting tubes are connected to one end of the pipeline joint 52 located inside the hatch 42, and then the hatch 42 and the preservation chamber 41 are screwed together and closed, and then the preservation assembly 4 is placed in the placement sleeve 3, and the annular placement frame 63 plays a supporting role for the preservation assembly 4. At this time, the clamping plate 129 at the bottom of the preservation chamber 41 passes through the clamping hole 127 and is inserted into the clamping groove 128 and the square groove of the disc 122, and then the preservation chamber 41 is rotated 90°. At this time, the lower end protrusion of the clamping plate 129 is clamped into the middle of the clamping groove 128. Since the groove width in the middle of the clamping groove 128 is greater than the top, the clamping plate 129 will be restricted from moving in the up and down directions. At the same time, the rotation of the storage chamber 41 drives the arc-shaped clamping shaft 62 to be clamped into the arc-shaped clamping sleeve 64, thereby fixing the storage chamber 41. Then the staff connects the soft delivery tube 10 to the outer ends of the pipeline connector 52 respectively; then the hard delivery tube 9 pump body can be controlled to work, thereby realizing the reflux of the active maintenance fluid in the ex vivo liver, and drugs such as heparin, glucose, saline, epinephrine, etc. can be added through the drug introduction device 91; red blood cells, artificial blood (such as HBOC) and other oxygen-carrying agents can also be added through the liver inlet pipeline 132. Then the motor 125 is started to work, the motor 125 drives the crankshaft 124 to rotate, the crankshaft 124 drives the sleeve 126 to rotate, the sleeve 126 slides on the disc 122 during rotation, the disc 122 drives the card plate 129 to move up and down, the card plate 129 drives the piston 112 to move up and down in the cylindrical cylinder 111, and then the connecting column 113 drives the placement plate 114 and the elastic membrane 115 to swing up and down, and then the ex vivo liver beats slightly under the action of the organ retention fluid and the elastic membrane 115, simulating the beating scene in the human body to maintain the activity of the liver. When the ex vivo liver needs to be temporarily transported, it is reversed to the rotating storage cabin 4190°, the card plate 129 rotates to the square groove position of the disc 122, and the arc-shaped card shaft 62 is separated from the arc-shaped card sleeve 64. Then, the soft delivery tube 10 is pulled out, the connector 55 of the temporary circulation component 5 is connected to the pipeline connector 52, and the exchange pump 56 is started to realize the temporary reflux of the active maintenance fluid, and the liver can still be perfused during the temporary transportation process to prevent the expansion of the hepatic sinus and the accumulation of the perfused active maintenance fluid. The device has a simple structure and is convenient for protecting and temporarily transporting the isolated liver.

[0032] Embodiment 2: Based on embodiment 1, Figure 1As shown, it also includes a pipeline 13, a liquid storage tank 14, a peristaltic pump 15 and a filter 16. A liquid storage tank 14 for storing organ retention fluid is arranged on the top right side of the base 1, and a constant temperature heater is arranged in the liquid storage tank 14; a peristaltic pump 15 is arranged on the top right side of the mounting platform 2, a liquid inlet 44 of the peristaltic pump 15 is connected to the liquid storage tank 14 through a hose, a liquid outlet is connected to the filter 16, the filter 16 is connected to the liquid inlet 44 through the pipeline 13, and another liquid inlet 44 of the preservation cabin 41 is connected to the liquid storage tank 14 through the pipeline 13.

[0033] When the organ preservation liquid needs to be replaced, the upper liquid inlet 44 can be connected to the filter 16 through the pipeline 13, the lower liquid inlet 44 can be connected to the liquid storage tank 14 through the pipeline 13, the valve 45 is opened, and the peristaltic pump 15 is started, so that the organ preservation liquid in the liquid storage tank 14 is injected into the preservation chamber 41, and the organ preservation liquid in the preservation chamber 41 circulates and flows into the liquid storage tank 14, and the filter 16 plays a filtering role. The constant temperature heater of the liquid storage tank 14 can keep the temperature of the organ preservation liquid circulating in the preservation chamber 41 consistent, and further protect the ex vivo organ.

[0034] like Figure 1 As shown, a stirrer 17 is also included. The preservation box 8 is provided with a stirrer 17 for stirring the liquid inside. The preset temperature inside the preservation box 8 is 33-37° C. The operation of the stirrer 17 can make the temperature of the active maintenance liquid in the preservation box 8 more uniform. The operation of the stirrer 17 can make the temperature of the active maintenance liquid in the preservation box 8 more uniform.

[0035] The technical principles of the embodiments of the present invention are described above in conjunction with specific embodiments. These descriptions are only for explaining the principles of the embodiments of the present invention and cannot be interpreted in any way as limiting the protection scope of the embodiments of the present invention. Based on the explanations herein, those skilled in the art can think of other specific implementation methods of the embodiments of the present invention without creative work, and these methods will fall within the protection scope of the embodiments of the present invention.

Claims

1. A liver oxygen-carrying mechanical perfusion device, characterized in that: include: A base (1), a mounting platform (2), wherein the top of the base (1) is provided with a mounting platform (2); a placement sleeve (3), wherein the left side of the mounting platform (2) is embedded with a placement sleeve (3) for placing a preservation component (4); a preservation component (4), wherein the preservation component (4) is used to store an ex vivo liver; a temporary circulation component (5), wherein the preservation component (4) is provided with a temporary circulation component (5) for injecting an arterial and venous active maintenance fluid into the ex vivo liver to maintain circulation; a fixing component (6), wherein the outside of the preservation component (4) is provided with a fixing component (6) for fixing the preservation component (4) to the placement sleeve (3); a limiting frame (7 ), a limit frame (7) is arranged at the middle side of the top of the base (1); a preservation box (8), wherein the limit frame (7) is arranged inside the preservation box (8); a hard delivery pipe (9), wherein two hard delivery pipes (9) are arranged through the preservation box (8), wherein the hard delivery pipes (9) are arranged through the mounting platform (2), wherein one of the hard delivery pipes (9) is connected to a pump body; a medicine introducer (91), wherein the mounting platform (2) is provided with a medicine introducer (91), wherein the medicine introducer (91) is connected to one of the hard delivery pipes (9); and a soft delivery pipe (10), wherein the ends of the two hard delivery pipes (9) are connected to the soft delivery pipes (10).

2. A liver oxygen-carrying mechanical perfusion device according to claim 1, characterized in that: The preservation assembly (4) comprises: a preservation chamber (41), a chamber cover (42) being screwed onto the preservation chamber (41); a temperature detector (43), a temperature detector (43) being embedded in the chamber cover (42); a liquid inlet (44), two liquid inlets (44) being disposed at the lower portion of the preservation chamber (41); and a valve (45), each of the liquid inlets (44) being provided with a valve (45).

3. A liver oxygen-carrying mechanical perfusion device according to claim 2, characterized in that: The temporary circulation assembly (5) comprises: a mounting plate (51), the hatch cover (42) being embedded with the mounting plate (51); a pipe joint (52), two pipe joints (52) being embedded with the mounting plate (51); a bracket (53), the bracket (53) being disposed on one side of the upper part of the hatch cover (42); a storage tank (54), the storage tank (54) being screwed onto the bracket (53); a connector (55), the bottom of the storage tank (54) being connected to the connector (55) via a hose, the connector (55) being connected to the pipe joint (52); an exchange pump (56), the bottom of the bracket (53) being provided with the exchange pump (56), the water inlet of the exchange pump (56) being connected to the storage tank (54); and the water outlet of the exchange pump (56) being connected to a connector (55) via a hose.

4. A liver oxygen-carrying mechanical perfusion device according to claim 3, characterized in that: The fixing assembly (6) comprises: a fixing block (61), the fixing block (61) being arranged at the lower part of the side wall of the storage chamber (41); an arc-shaped clamping shaft (62), the fixing block (61) being arranged with the arc-shaped clamping shaft (62); an annular placement rack (63), the annular placement rack (63) being arranged at the lower inner side of the placement sleeve (3); and an arc-shaped clamping sleeve (64), the side wall of the placement sleeve (3) being arranged with the arc-shaped clamping shaft (62) cooperating with the placement sleeve (3).

5. A liver oxygen-carrying mechanical perfusion device according to claim 4, characterized in that: The liver oxygen-carrying mechanical perfusion device further comprises a placement component (11), the placement component (11) comprising a columnar cylinder (111), the columnar cylinder (111) being embedded in the bottom of the storage chamber (41); a piston (112), the piston (112) being slidably disposed in the columnar cylinder (111); a connecting column (113), the connecting column (113) being disposed at the center of the top of the piston (112); a placement plate (114), the placement plate (114) being disposed on the top of the connection column (113); and an elastic membrane (115), the elastic membrane (115) being disposed in the placement plate (114).

6. A liver oxygen-carrying mechanical perfusion device according to claim 5, characterized in that: The liver oxygen-carrying mechanical perfusion device also includes an adjustment component (12), which includes: a guide column (121), on which the guide column (121) is symmetrically arranged at the bottom of the placement sleeve (3); a disk (122), on which the disks (122) are slidably arranged on the two guide columns (121); a bearing seat (123), on which the bearing seat (123) is symmetrically arranged at the bottom of the placement sleeve (3); a crankshaft (124), on which the crankshaft (124) is rotatably arranged between the two bearing seats (123), and the crankshaft (124) is located between the two guide columns (121); and a motor (125), on which the motor (125) is arranged at the bottom of the placement sleeve (3). The motor (125) is arranged at the bottom of the placement sleeve (3). The output shaft of the piston (112) is connected to one end of the crankshaft (124) through a coupling; a sleeve (126), the bent portion of the crankshaft (124) is sleeved with the sleeve (126), the sleeve (126) is slidably matched with a slot at the bottom of the disc (122); a clamping plate (129), a clamping hole (127) is provided at the center of the bottom of the storage chamber (41), a clamping plate (129) is provided at the bottom of the piston (112), a clamping groove (128) is provided at the top of the disc (122), the groove width of the middle part of the clamping groove (128) is greater than the groove width of the top part, and square grooves are symmetrically opened on the disc (122), the square grooves are connected with the clamping groove (128), and the clamping plate (129) is matched with the clamping groove (128).

7. A liver oxygen-carrying mechanical perfusion device according to claim 6, characterized in that: The apparatus further comprises a liquid storage tank (14), wherein the liquid storage tank (14) for storing organ retention fluid is arranged on the right side of the top of the base (1), and a constant temperature heater is arranged in the liquid storage tank (14); a peristaltic pump (15), wherein the peristaltic pump (15) is arranged on the right side of the top of the mounting platform (2), and the liquid inlet (44) of the peristaltic pump (15) is connected to the liquid storage tank (14) through a hose; a filter (16), wherein the liquid outlet of the peristaltic pump (15) is connected to the filter (16); and a pipeline (13), wherein the filter (16) is connected to the liquid inlet (44) through the pipeline (13), and another liquid inlet (44) of the storage chamber (41) is connected to the liquid storage tank (14) through the pipeline (13).

8. A liver oxygen-carrying mechanical perfusion device according to claim 7, characterized in that: Also includes: A stirrer (17), wherein the storage box (8) is provided with a stirrer (17) for stirring the liquid inside.

9. A liver oxygen-carrying mechanical perfusion device according to claim 8, characterized in that: The temperature in the storage box (8) is preset to be 33-37°C.

Images