Micro-nano bubble generation device and method based on microfluidic co-flow stepped emulsification

Abstract

The invention discloses a micro-nano bubble generation device and method based on micro-fluidic co-flow stepped emulsification. The device comprises a micro-fluidic chip; the micro-fluidic chip is provided with a shallow channel and a deep channel; the shallow channel comprises a liquid channel and a sheath flow channel; the liquid channel is communicated with the sheath flow channel in a cross intersection manner; two ends of the liquid channel are communicated with a continuous phase fluid source; the first end of the sheath flow channel is communicated with a dispersed phase gas source; the second end of the sheath flow channel is communicated with the deep layer channel; and a step structure is arranged at the communicating position of the sheath flow channel and the deep channel, and the step structure can enable the fluid in the sheath flow channel to generate necking fracture when flowing through the step structure, so that micro-nano bubbles are formed. And the generation quality and the generation efficiency of the micro-nano bubbles are improved.

Description

Technical Field

[0001] The present invention relates to the field of microfluidic technology, and in particular to a micro-nano bubble generating device and method based on microfluidic co-flow step-by-step emulsification. Background Art

[0002] The statements in this section merely provide background information related to the present invention and do not necessarily constitute prior art.

[0003] In today's scientific research and industrial application fields, micro-nano bubbles are gradually becoming a hot topic of research due to their unique physical and chemical properties and broad application prospects. Micro-nano bubbles have significant characteristics such as large specific surface area, long residence time, and high mass transfer efficiency, and have shown great potential in many fields such as environmental protection, biomedicine, and food industry. At present, the generation technologies of micro-nano bubbles include cyclonic liquid flow, pressurized dissolution, and micropore methods, but there are problems such as low or high bubble concentration, uneven bubble diameter, and poor stability, which limit the efficiency and effect of micro-nano bubbles in practical applications.

[0004] Microfluidic chip technology is a technology that can precisely manipulate fluids at a microscale. This technology not only allows tiny cells and small organic molecules to perform biochemical reactions in the specific channel environment of the chip, but also provides ideal conditions for the generation of microdroplets and micro-nano bubbles, converting gases and liquids into emulsified microbubbles or small droplets, providing new pathways for drug delivery and biochemical reactions. However, despite attempts to combine microfluidics with micro-nano bubble generation, the flow focusing structures used in existing methods still have problems with insufficient micro-nano bubble density and excessive spacing between bubbles, which leads to reduced efficiency in specific applications such as cleaning. Therefore, developing a new method that can produce high-density and uniformly distributed micro-nano bubbles is of great significance for improving the efficiency and effectiveness of related applications. Summary of the invention

[0005] In order to solve the above problems, the present invention proposes a micro-nano bubble generation device and method based on microfluidic co-flow step emulsification, which can produce micro-nano bubbles of uniform size and improve the generation density of micro-nano bubbles.

[0006] To achieve the above object, the present invention adopts the following technical solution:

[0007] In the first aspect, a micro-nano bubble generation device based on microfluidic co-flow step emulsification is proposed, including a microfluidic chip; a shallow channel and a deep channel are arranged on the microfluidic chip;

[0008] The shallow channel includes a liquid channel and a sheath flow channel; the liquid channel and the sheath flow channel are connected in a cross-intersection manner;

[0009] Both ends of the liquid channel are connected to the continuous phase fluid source; the first end of the sheath flow channel is connected to the dispersed phase gas source; the second end of the sheath flow channel is connected to the deep channel;

[0010] A step structure is arranged at the connection point between the sheath flow channel and the deep channel, and the step structure can cause the fluid in the sheath flow channel to neck and break when flowing through the step structure, thereby forming micro-nano bubbles.

[0011] Furthermore, the distance between the bottom of the shallow channel and the upper surface of the microfluidic chip is smaller than the distance between the bottom of the deep channel and the upper surface of the microfluidic chip.

[0012] Further, the liquid channel is connected to the continuous phase inlet; the continuous phase inlet is connected to the continuous phase fluid source;

[0013] The sheath flow channel is communicated with the dispersed phase inlet, and the dispersed phase inlet is communicated with the dispersed phase gas source.

[0014] Furthermore, the dispersed phase gas source and the continuous phase fluid source are both connected to a driving gas source, and the driving gas source is used to press the dispersed phase gas in the dispersed phase gas source and the continuous phase fluid in the continuous phase fluid source into the shallow channel.

[0015] Furthermore, controllers are respectively arranged on the pipelines connecting the dispersed phase gas source and the driving gas source, and on the pipelines connecting the continuous phase fluid source and the driving gas source; the controllers are used to adjust the gas pressure of the driving gas source entering the dispersed phase gas source and the continuous phase fluid source.

[0016] Furthermore, the sheath flow channel is connected to the middle portion of the liquid channel.

[0017] Furthermore, the deep channel is communicated with the bubble outlet.

[0018] Secondly, a method for generating micro-nano bubbles based on microfluidic co-flow step emulsification is proposed, including:

[0019] introducing a continuous phase fluid into the liquid channel;

[0020] introducing dispersed phase gas into the sheath flow channel;

[0021] The dispersed phase gas and the continuous phase fluid form a sheath flow at the intersection of the liquid channel and the sheath flow channel;

[0022] When the sheath flow passes through the stepped structure, necking and breaking occur, generating micro-nano bubbles, which then enter the deep channel.

[0023] Furthermore, by driving the gas source to introduce gas into the dispersed phase gas source and the continuous phase fluid source, the continuous phase fluid in the continuous phase fluid source and the dispersed phase gas in the dispersed phase gas source are pressed into the liquid channel; and the dispersed phase gas in the dispersed phase gas source is pressed into the sheath flow channel.

[0024] Furthermore, the controller is used to adjust the gas pressure of the driving gas source passing into the dispersed phase gas source and the continuous phase fluid source, thereby adjusting the flow rate of the dispersed phase gas and the flow rate of the continuous phase fluid.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] The present invention proposes a micro-nano bubble generation device and method based on microfluidic co-flow step emulsification, wherein the device comprises a microfluidic chip; a shallow channel and a deep channel are arranged on the microfluidic chip, and a step structure is arranged between the shallow channel and the deep channel; when dispersed phase gas and continuous phase fluid are introduced into the shallow channel, the dispersed phase gas and the continuous phase fluid will form a sheath flow at the cross intersection of the liquid channel and the sheath flow channel; when the sheath flow passes through the step structure, it will neck and break to form micro-nano bubbles, thereby ensuring the generation of micro-nano bubbles of uniform size and being able to improve the generation density of micro-nano bubbles; the problem of uncontrollable size of micro-nano bubble production and complex operation in the traditional micro-nano bubble generation method is solved, and the quality and efficiency of micro-nano bubble generation are effectively improved.

[0027] Advantages of additional aspects of the present invention will be given in part in the following description, and in part will become obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The drawings in the specification, which constitute a part of the present application, are used to provide further understanding of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute improper limitations on the present application.

[0029] Figure 1 It is a schematic structural diagram of a micro-nano bubble generating device based on microfluidic co-flow step emulsification disclosed in an embodiment;

[0030] Figure 2 Schematic diagram of generating micro-nano bubbles using a micro-nano bubble generating device based on microfluidic co-flow step emulsification;

[0031] Figure 3 The continuous phase and dispersed phase gas pressure curves and the generated micro-nano bubble diagrams disclosed in the embodiments;

[0032] Figure 4 Flow rate curves of the continuous phase and dispersed phase and the generated micro-nano bubbles disclosed in the examples.

[0033] Among them: 1. pressure pump; 2. controller; 3. gas pipeline; 4. dispersed phase gas storage bottle; 5. continuous phase liquid storage bottle; 6. dispersed phase gas; 7. continuous phase fluid; 8. fluid pipeline; 9. microfluidic chip; 10. shallow channel; 11. deep channel; 12. sheath flow; 13. micro-nano bubbles. DETAILED DESCRIPTION

[0034] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0035] It should be noted that the following detailed descriptions are illustrative and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present application belongs.

[0036] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0037] In the present invention, terms such as "fixed connection", "connected", "connection", etc. should be understood in a broad sense, indicating that it can be fixedly connected, integrally connected or detachably connected; it can be directly connected or indirectly connected through an intermediate medium. Relevant scientific research or technical personnel in this field can determine the specific meanings of the above terms in the present invention according to specific circumstances, and they should not be understood as limiting the present invention.

[0038] In the absence of conflict, the embodiments of the present invention and the features of the embodiments may be combined with each other.

[0039] The present invention discloses a micro-nano bubble generating device based on microfluidic co-flow step-by-step emulsification, such as Figure 1 , Figure 2 As shown, it includes a microfluidic chip 9; a shallow channel 10 and a deep channel 11 are arranged on the microfluidic chip 9;

[0040] The shallow channel 10 includes a liquid channel and a sheath flow channel; the liquid channel and the sheath flow channel are connected in a cross-intersection manner;

[0041] Both ends of the liquid channel are connected to the continuous phase fluid source; the first end of the sheath flow channel is connected to the dispersed phase gas source; the second end of the sheath flow channel is connected to the deep channel 11;

[0042] A step structure is provided at the connection point between the sheath flow channel and the deep channel 11 , and the step structure can cause the fluid in the sheath flow channel to neck and break when flowing through the step structure, thereby forming micro-nano bubbles 13 .

[0043] The distance between the shallow channel of the present invention and the upper surface of the microfluidic chip is smaller than the distance between the deep channel and the upper surface of the microfluidic chip, thereby forming a step structure at the connection point between the sheath flow channel and the deep channel 11, so that the fluid in the sheath flow channel can neck and break when flowing through the step structure.

[0044] Preferably, the distance between the shallow channel and the upper surface of the microfluidic chip is 1 mm, and the distance between the deep channel and the upper surface of the microfluidic chip is 2 mm.

[0045] The present invention also provides a dispersed phase inlet and a continuous phase inlet on the microfluidic chip 9; the liquid channel is connected to the continuous phase inlet; the continuous phase inlet is connected to the continuous phase fluid source; the sheath flow channel is connected to the dispersed phase inlet, and the dispersed phase inlet is connected to the dispersed phase gas source. The liquid channel is connected to the continuous phase inlet.

[0046] The dispersed phase gas stored in the dispersed phase gas source enters the sheath flow channel through the dispersed phase inlet; the continuous phase fluid stored in the continuous phase fluid source enters the liquid channel through the continuous phase inlet; the dispersed phase gas and the continuous phase fluid form a sheath flow 12 at the cross intersection of the liquid channel and the sheath flow channel; when the sheath flow passes through the stepped structure and reaches the deep channel, the initial disturbance between the continuous phase fluid and the dispersed phase gas interface is instantly amplified, and a sudden Laplace pressure difference is quickly generated, which squeezes the dispersed phase gas 6 to neck and fracture, and forms micro-nano bubbles after crossing the stepped structure, and the generated micro-nano bubbles enter the deep channel; as the continuous phase fluid and the dispersed phase gas continue to pass into the shallow channel, micro-nano bubbles of uniform size continue to be generated. The generation quality and generation efficiency of micro-nano bubbles are improved.

[0047] In specific implementation, the sheath flow channel is connected to the middle part of the liquid channel, so that the gas in the sheath flow channel is subjected to the same squeezing force from the liquid on both sides, ensuring the formation of sheath flow at the cross intersection of the shallow channel and enabling the sheath flow to continue to move toward the deep channel.

[0048] The deep channel of the present invention is connected with the bubble outlet, so that the micro-nano bubbles in the deep channel can be discharged from the deep channel through the bubble outlet.

[0049] In specific implementation, the dispersed phase gas source adopts a dispersed phase gas storage bottle 4, in which the dispersed phase gas 6 is stored; the continuous phase fluid source adopts a continuous phase liquid storage bottle 5, in which the continuous phase fluid 7 is stored.

[0050] The dispersed phase gas is air or other specific gases.

[0051] The continuous phase fluid is a mixed solution formed by 70% PEGDA (polyethylene glycol diacrylate), 30% water, 4% IRGACURE 184 (photoinitiator) and 1.5% SDS (sodium dodecyl sulfate), or other mixed solutions.

[0052] The dispersed phase gas and the continuous phase fluid are determined according to specific usage requirements.

[0053] The dispersed phase gas source and the continuous phase fluid source of the present invention are both connected to the driving gas source, and the driving gas source is used to introduce gas into the dispersed phase gas source and the continuous phase fluid source, thereby pressing the gas in the dispersed phase gas source and the liquid in the continuous phase fluid source into the shallow channel.

[0054] The present invention also provides controllers 2 on the pipeline connecting the dispersed phase gas source and the driving gas source, and on the pipeline connecting the continuous phase fluid source and the driving gas source; controller 2 is used to adjust the gas pressure of the driving gas source entering the dispersed phase gas source and the continuous phase fluid source, thereby adjusting the flow rate of the dispersed phase gas and the continuous phase fluid entering the shallow channel.

[0055] In specific implementation, the compressed gas source and the controller 2, the controller 2 and the dispersed phase gas source, and the controller 2 and the continuous phase fluid source are all connected through the gas pipeline 3; the dispersed phase gas source and the dispersed phase inlet, and the continuous phase fluid source and the continuous phase inlet are respectively connected through the liquid pipeline 8.

[0056] The gas pipeline 3 and the liquid pipeline 8 can be made of glass, silicone, plastic or other materials.

[0057] The compressed gas source includes a pressure pump 1, which is a vane pump, a volumetric pump or an electromagnetic pump. The gas pressure output by the pressure pump is 0 to 10 kPa, such as 5 kPa, 7 kPa, 8 kPa, 9 kPa or 10 kPa, but is not limited to the listed values. Other values ​​within this numerical range are also applicable.

[0058] The controller 2 is a solenoid valve, etc. The pressure adjustment range of the controller 2 is 0 to 10 kPa, such as 5 kPa, 6 kPa, 8 kPa, 9 kPa or 10 kPa, but is not limited to the listed values, and other values ​​within the range are also applicable.

[0059] After the gas and liquid form a sheath flow at the cross intersection of the shallow channel, the flow rate of the sheath flow in the sheath flow channel is 0μl / min to 500μl / min, such as 5μl / min, 10μl / min, 50μl / min or 300μl / min, but is not limited to the listed values, and other values ​​within this numerical range are also applicable.

[0060] The size of the micro-nano bubbles generated by the micro-nano bubble generating device based on microfluidic co-flow step emulsification disclosed in the present invention is 1 μm to 500 μm, such as 10 μm, 50 μm, 100 μm or 250 μm, but is not limited to the listed values, and other values ​​within this numerical range are also applicable.

[0061] The frequency of generating micro-nano bubbles using the micro-nano bubble generating device based on microfluidic co-flow step emulsification disclosed in the present invention is 1 Hz to 2000 Hz, such as 20 Hz, 500 Hz, 1000 Hz or 1500 Hz, but is not limited to the listed values, and other values ​​within this numerical range are also applicable.

[0062] The micro-nano bubble generating device based on microfluidic co-flow stepped emulsification disclosed by the present invention has the advantages that when the liquid flow rate in the liquid channel remains unchanged, the greater the flow rate of the gas introduced into the sheath flow channel, the larger the size of the generated micro-nano bubbles, and the size of the micro-nano bubbles is positively correlated with the gas flow rate.

[0063] When the gas pressure of the continuous phase fluid source remains unchanged, the greater the pressure of the dispersed phase gas source, the larger the size of the generated micro-nano bubbles, and the size of the micro-nano bubbles is positively correlated with the gas pressure of the dispersed phase gas source.

[0064] The present invention also discloses a method for generating micro-nano bubbles based on microfluidic co-flow stepwise emulsification, comprising:

[0065] introducing a continuous phase fluid into the liquid channel;

[0066] introducing dispersed phase gas into the sheath flow channel;

[0067] The dispersed phase gas and the continuous phase fluid form a sheath flow at the intersection of the liquid channel and the sheath flow channel;

[0068] When the sheath flow passes through the stepped structure, necking and breaking occur, generating micro-nano bubbles, which then enter the deep channel.

[0069] In the specific implementation, the gas is introduced into the dispersed phase gas source and the continuous phase fluid source by driving the gas source, so that the continuous phase fluid in the continuous phase fluid source and the dispersed phase gas in the dispersed phase gas source are pressed into the liquid channel; and the dispersed phase gas in the dispersed phase gas source is pressed into the sheath flow channel.

[0070] The controller is used to adjust the gas pressure of the driving gas source passing into the dispersed phase gas source and the continuous phase fluid source, thereby adjusting the flow rate of the dispersed phase gas and the flow rate of the continuous phase fluid.

[0071] The micro-nano bubble generation method based on microfluidic co-flow step emulsification disclosed in the present invention is applied to the micro-nano bubble generation device based on microfluidic co-flow step emulsification disclosed in the present invention. Through different embodiments, the micro-nano bubble generation method based on microfluidic co-flow step emulsification disclosed in the present invention is described in detail.

[0072] Example 1

[0073] The micro-nano bubble generation method based on microfluidic co-flow step-wise emulsification disclosed in this embodiment includes:

[0074] (1) The pressure pump 1 compresses the external air and delivers it to the controller 2;

[0075] (2) The controller 2 adjusts the gas pressure, sets a specific gas pressure value, and delivers 750Pa and 450Pa compressed gases to the continuous phase liquid storage bottle 5 and the dispersed phase gas storage bottle 4 respectively through the gas pipeline 3; the continuous phase fluid 7 and the dispersed phase gas 6 are squeezed by the high-pressure gas, pass through the fluid pipeline 8, enter the dispersed phase inlet and the continuous phase inlet of the microfluidic chip 9, and enter the shallow channel 10;

[0076] (3) The continuous phase fluid 7 and the dispersed phase gas 6 form a sheath flow 12 at the cross intersection of the shallow channel, and the formed sheath flow 12 moves along the sheath flow channel toward the deep channel;

[0077] (4) When the sheath flow 12 crosses the stepped structure and enters the deep channel 11, the spatial mutation causes the disturbance on the interface of the two-phase fluid to be instantly amplified, thereby increasing the change in the interface curvature, that is, the Laplace pressure difference on both sides of the interface increases; the Laplace stress causes the interface curvature to be further enhanced, and the dispersed phase gas 6 is squeezed by the continuous phase fluid 7 on both sides to form a contraction neck; the contraction neck breaks, and the broken dispersed phase gas 6 enters the deep channel 11 and forms spherical micro-nano bubbles 13 under the principle of minimum surface energy;

[0078] (5) Step (4) is repeated alternately, the sheath flow 12 body retracts into the shallow channel 10, and under the drive of the pressure source, the next micro-nano bubble generation process begins, such as Figure 2 The macroscopic manifestation is the high-frequency oscillation of the dispersed phase gas 6 at the step structure, and the continuous ejection of micro-nano bubbles 13, as shown in FIG. Figure 3 As shown in (a).

[0079] Example 2

[0080] The micro-nano bubble generation method based on microfluidic co-flow step emulsification disclosed in this embodiment is different from that in embodiment 1 in that the gas pressures of the dispersed phase gas storage bottle 4 and the continuous phase liquid storage bottle 5 are 600Pa and 750Pa respectively, and the high-pressure gas drives the dispersed phase gas 6 and the continuous phase fluid 7 to form a sheath flow 12. Under the continuous drive of the above-mentioned high-pressure gas, micro-nano bubbles 13 are formed. Figure 3 As shown in (b).

[0081] Combination Figure 3 It can be found that when the gas pressure introduced into the continuous phase storage bottle 5 is maintained at the same level, the greater the gas pressure introduced into the dispersed phase storage bottle, the larger the size of the generated micro-nano bubbles is, showing a positive correlation.

[0082] Example 3

[0083] The micro-nano bubble generation method based on microfluidic co-flow step-wise emulsification disclosed in this embodiment includes:

[0084] (1) The pressure pump 1 compresses the external air and delivers it to the controller 2;

[0085] (2) The controller 2 adjusts the gas pressure, sets a specific gas pressure value, and delivers the compressed gas to the continuous phase liquid storage bottle 5 and the dispersed phase gas storage bottle 4 respectively through the gas pipeline 3; the continuous phase fluid 7 and the dispersed phase gas 6 are squeezed by the high-pressure gas, pass through the fluid pipeline 8, enter the dispersed phase inlet and the continuous phase inlet of the microfluidic chip 9, and enter the shallow channel 10; wherein the flow rate of the continuous phase fluid 7 is 7.5 μl / min, and the flow rate of the dispersed phase gas 6 is 2.5 μl / min;

[0086] (3) The continuous phase fluid 7 and the dispersed phase gas 6 form a sheath flow 12 at the cross intersection of the shallow channel, and the formed sheath flow 12 moves along the sheath flow channel toward the deep channel.

[0087] (4) When the sheath flow 12 crosses the stepped structure and enters the deep channel 11, the spatial mutation causes the disturbance on the interface of the two-phase fluid to be instantly amplified, thereby increasing the change in the interface curvature, that is, the Laplace pressure difference on both sides of the interface increases; the Laplace stress causes the interface curvature to be further enhanced, and the dispersed phase gas 6 is squeezed by the continuous phase fluid 7 on both sides to form a contraction neck; the contraction neck breaks, and the broken dispersed phase gas 6 enters the deep channel 11 and forms spherical micro-nano bubbles 13 under the principle of minimum surface energy;

[0088] (5) Step (4) is repeated alternately, and the sheath flow 12 body retracts into the shallow channel 10, and under the drive of the pressure source, the next micro-nano bubble generation process begins. The macroscopic manifestation is the high-frequency oscillation of the dispersed phase gas 6 at the step structure, and the continuous ejection of micro-nano bubbles 13, as shown in FIG. Figure 4 As shown in (a).

[0089] Example 4

[0090] This embodiment provides a method for increasing the density of micro-nano bubbles. Figure 4 As shown, the difference from Example 3 is that the flow rates of the dispersed phase gas 6 and the continuous phase fluid 7 are 7.5 μl / min and 5 μl / min respectively, and the high-pressure gas pushes the dispersed phase gas 6 and the continuous phase fluid 7 to form a sheath flow 12. Under the motion conditions of the above fluid flow rates, the micro-nano bubbles 13 are formed, as shown in FIG. Figure 4 As shown in (b).

[0091] Combination Figure 4 It can be found that when the flow rate of the continuous phase fluid 7 remains unchanged, the greater the flow rate of the dispersed phase gas 6 is, the larger the size of the generated micro-nano bubbles 13 is, showing a positive correlation.

[0092] Although the above describes the specific implementation mode of the present invention in conjunction with the accompanying drawings, it is not intended to limit the scope of protection of the present invention. Those skilled in the art should understand that various modifications or variations that can be made by those skilled in the art on the basis of the technical solution of the present invention without creative work are still within the scope of protection of the present invention.

Claims

1. Micro-nano bubble generation device based on microfluidic co-flow step emulsification, It is characterized in that The microfluidic chip comprises a microfluidic chip; a shallow channel and a deep channel are arranged on the microfluidic chip; The shallow channel includes a liquid channel and a sheath flow channel; the liquid channel and the sheath flow channel are connected in a cross-intersection manner; Both ends of the liquid channel are connected to the continuous phase fluid source; the first end of the sheath flow channel is connected to the dispersed phase gas source; the second end of the sheath flow channel is connected to the deep channel; A step structure is arranged at the connection point between the sheath flow channel and the deep channel, and the step structure can cause the fluid in the sheath flow channel to neck and break when flowing through the step structure, thereby forming micro-nano bubbles.

2. The micro-nano bubble generating device based on microfluidic co-flow stepwise emulsification as claimed in claim 1, It is characterized in that The distance between the bottom of the shallow channel and the upper surface of the microfluidic chip is smaller than the distance between the bottom of the deep channel and the upper surface of the microfluidic chip.

3. The micro-nano bubble generating device based on microfluidic co-flow stepwise emulsification as claimed in claim 1, It is characterized in that The liquid channel is connected to the continuous phase inlet; the continuous phase inlet is connected to the continuous phase fluid source; The sheath flow channel is communicated with the dispersed phase inlet, and the dispersed phase inlet is communicated with the dispersed phase gas source.

4. The micro-nano bubble generating device based on microfluidic co-flow stepwise emulsification as claimed in claim 1, It is characterized in that The dispersed phase gas source and the continuous phase fluid source are both connected to the driving gas source, and the driving gas source is used to press the dispersed phase gas in the dispersed phase gas source and the continuous phase fluid in the continuous phase fluid source into the shallow channel.

5. The micro-nano bubble generating device based on microfluidic co-flow stepwise emulsification as claimed in claim 4, It is characterized in that Controllers are respectively arranged on the pipelines connecting the dispersed phase gas source and the driving gas source, and on the pipelines connecting the continuous phase fluid source and the driving gas source; the controllers are used to adjust the gas pressure of the driving gas source entering the dispersed phase gas source and the continuous phase fluid source.

6. The micro-nano bubble generating device based on microfluidic co-flow stepwise emulsification as claimed in claim 1, It is characterized in that The sheath flow channel is connected with the middle portion of the liquid channel.

7. The micro-nano bubble generating device based on microfluidic co-flow stepwise emulsification as claimed in claim 1, It is characterized in that The deep channel is connected with the bubble outlet.

8. Micro-nano bubble generation method based on microfluidic co-flow step emulsification, It is characterized in that include: introducing a continuous phase fluid into the liquid channel; introducing dispersed phase gas into the sheath flow channel; The dispersed phase gas and the continuous phase fluid form a sheath flow at the intersection of the liquid channel and the sheath flow channel; When the sheath flow passes through the stepped structure, necking and breaking occur, generating micro-nano bubbles, which then enter the deep channel.

9. The method for generating micro-nano bubbles based on microfluidic co-flow stepwise emulsification as claimed in claim 8, It is characterized in that By driving the gas source to introduce gas into the dispersed phase gas source and the continuous phase fluid source, the continuous phase fluid in the continuous phase fluid source and the dispersed phase gas in the dispersed phase gas source are pressed into the liquid channel; the dispersed phase gas in the dispersed phase gas source is pressed into the sheath flow channel.

10. The method for generating micro-nano bubbles based on microfluidic co-flow stepwise emulsification according to claim 8, It is characterized in that The controller is used to adjust the gas pressure of the driving gas source passing into the dispersed phase gas source and the continuous phase fluid source, thereby adjusting the flow rate of the dispersed phase gas and the flow rate of the continuous phase fluid.

Images