Small full-automatic platelet aggregation instrument

Abstract

The invention discloses a small full-automatic platelet aggregation instrument which comprises a rack, the reaction cup conveying device is used for feeding reaction cups and stirrers; the centrifugal machine is used for centrifugally separating a sample in the reaction cup; the rotary detection device is used for mixed detection of reagents and samples; the reagent suction mechanical arm is used for adding a reagent into the reaction cup; the grabbing mechanical arm is used for moving the reaction cup in different devices; the sample feeding device is used for feeding and discharging samples, and the sample suction mechanical arm is used for transferring the samples; the waste bin is used for collecting the detected waste reaction cups. According to the small-sized full-automatic platelet aggregation instrument provided by the invention, through ingenious structural design and layout, the size of the whole instrument is smaller, and meanwhile, automatic operation of each environment can be realized.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnostic testing, and in particular to a small-sized fully automatic platelet aggregation instrument. Background Art

[0002] Platelet aggregation function testing is suitable for analyzing the aggregation rate of platelets and other related functional parameters in blood samples. It can be used to monitor platelet collection, storage and transfusion, to diagnose and monitor hemorrhagic diseases, to facilitate the monitoring and testing of clinical antiplatelet drug use, and can also be used for coagulation function testing before and after surgery.

[0003] At present, small-volume, fully automatic platelet aggregation instruments used in photoelectric turbidimetry are still scarce in the domestic and foreign markets, and most of them are still large-scale fully automatic or semi-automatic platelet aggregation instruments. The platelet aggregation equipment in the current market has the following problems:

[0004] Although the semi-automatic platelet aggregation instrument is small in size and can be used in laboratories or testing departments with limited space, it requires operators to spend a lot of time on sample pre-treatment, such as manual centrifugation, manual sample addition, manual mixing, manual loading and other tedious processes, and the detection efficiency is not high;

[0005] Although large-scale platelet aggregometers have achieved a high degree of automation and greatly improved detection efficiency, their large size has placed great demands on the available space in some departments, and the cost of the entire machine remains high, which indirectly leads to higher costs for individual testing. The stirrer transmission devices in most conventional fully automatic platelet aggregometers still require manual pre-installation, which has low efficiency, low reliability and high cost. Summary of the invention

[0006] The purpose of the present invention is to provide a small fully automatic platelet aggregation instrument, which, through ingenious structural design and layout, makes the volume of the whole machine more compact and can realize automatic operation in each environment.

[0007] The technical solution adopted by a small fully automatic platelet aggregation instrument disclosed in the present invention is:

[0008] A small fully automatic platelet aggregation instrument comprises a frame;

[0009] A reaction cup transmission device, the reaction cup transmission device comprising a silo mechanism and a stirring bar adding mechanism, the silo mechanism is used for loading the reaction cup, the stirring bar mechanism is arranged on one side of the silo mechanism, and the stirring bar adding mechanism is used for adding the stirring bar into the loaded reaction cup;

[0010] A centrifuge, which is arranged on one side of the rotating detection device and is used to centrifuge the sample in the reaction cup;

[0011] A rotation detection device, the rotation detection device comprises a rotating module, a reagent disk module and a detection module, the reagent disk module is fixedly connected to the rotating module, the rotating module drives the reagent disk module to rotate, the reagent disk module is used to place a plurality of reagent bottles, the detection module is arranged around the reagent disk module, and the detection module is fixedly connected to the reagent disk module, and the detection module is used to place a plurality of reaction cups;

[0012] A reagent suction mechanical arm, the rotation track of which covers the reagent disk module and the detection module of the rotating detection device, the reagent suction mechanical arm is used to suck the reagent in the reagent disk in the rotating detection device and add it to the reaction cup in the detection module, and the reagent suction mechanical arm is correspondingly provided with a reagent cleaning pool, and the reagent cleaning pool is located on the rotation track of the reagent suction mechanical arm;

[0013] A grabbing robot arm, which is arranged on one side of the centrifuge, and whose rotation track covers the silo mechanism, the centrifuge and the detection module, and is used to grab and transfer the reaction cup on the silo mechanism to the centrifuge and the detection module;

[0014] A sample introduction device, the sample introduction device is located on one side of the rotating detection device, the sample introduction device is used for placing and delivering samples to the sample tube, a sample suction mechanical arm is provided between the sample introduction device and the rotating detection device, the rotation track of the sample suction mechanical arm covers the sample delivery device and the detection module, the sample suction mechanical arm is used to suck the sample in the sample tube and add it to the detection module, the sample suction mechanical arm is correspondingly provided with a sample cleaning pool, and the sample cleaning pool is located on the rotation track of the sample suction mechanical arm;

[0015] A waste bin is located on the rotation track of the grabbing robot arm, and is used to collect discarded reaction cups after the test is completed.

[0016] As a preferred embodiment, the hopper mechanism includes a first hopper and a material pushing assembly, the material pushing assembly is arranged inside the first hopper, and the material pushing assembly is used to push out the reaction cup in the first hopper individually. A slide rail is provided on one side of the first hopper, and the slide rail is formed by two groups of baffles arranged relatively and spaced apart. The upper end of the slide rail is inclined downward along the upper end of the first hopper, and the width of the slide rail is greater than the cup body diameter of the reaction cup and less than the cup cover width; a cup pushing mechanism is provided at the lower end of the slide rail, and the cup pushing mechanism is correspondingly arranged at the lower end of the slide rail, and the cup pushing mechanism pushes the reaction cup that slides out from the lower end of the slide rail toward the bottom of the stirring bar adding mechanism.

[0017] As a preferred embodiment, the stirring bar adding mechanism includes a second hopper and a pushing mechanism, a base and a guide seat are provided inside the second hopper, the guide seat is in a V-shaped inclined surface structure away from the base, the guide seat is arranged above the base, and there is a gap between the guide seat and the base to form a pushing channel, and a first through hole is provided in the middle of the guide seat, the first through hole is connected to the pushing channel, a discharge port is provided on one side of the base, the discharge port is connected to the pushing channel, and the discharge port is located above the pushing cup mechanism, the base is provided with a first magnet corresponding to the first through hole, a push rod is slidably provided in the pushing channel, a second through hole for accommodating the stirring bar is opened at one end of the push rod, and the second through hole is arranged at one end close to the discharge port, the pushing mechanism is arranged on one side of the second hopper, and the pushing device drives the push rod to slide left and right along the pushing channel.

[0018] As a preferred embodiment, the rotating module includes a stepper motor, a main shaft, a driving pulley, a driven pulley, a synchronous belt and a support plate. The stepper motor is fixed in a frame, and the output shaft of the stepper motor is provided with a driving pulley. One end of the main shaft is fixed under the reagent disk module. The main shaft is rotatably connected to the support plate through a bearing, and the support plate is fixedly connected to the frame. The driven pulley is arranged at the other end of the main shaft, and the driving pulley and the driven pulley are connected through a synchronous belt.

[0019] As a preferred embodiment, the reagent disk module includes a refrigeration pot, a semiconductor refrigeration sheet, an RFID card reader and a turntable. The refrigeration pot is fixedly connected to the frame, the RFID card reader is fixed to the inner wall of the refrigeration pot, the semiconductor refrigeration sheet is fixed to the bottom of the refrigeration pot corresponding to the RFID card reader, and the outer periphery of the refrigeration pot is wrapped with thermal insulation cotton. The turntable is rotatably arranged inside the refrigeration pot, and the turntable is fixedly connected to one end of the main shaft. Several external gears are provided on the surface of the turntable for rotating around the rear center, and a card hole for placing a reagent bottle is provided above the external gear. An internal gear ring is provided inside the refrigeration pot, and the external gear and the internal gear ring are meshed with each other.

[0020] As a preferred embodiment, the detection module includes three reaction disks, a connecting disk and a reagent cover. The three reaction disks are all arc-shaped structures. The three reaction disks are replaced with a ring structure around the refrigeration pot. The reaction disk is provided with a plurality of placement holes for placing reaction cups. The connecting disk is arranged above the reaction disk. The connecting disk is used to fix the three reaction disks, and the connecting disk is provided with corresponding placement holes and through holes. The connecting disk has an avoidance hole in the middle, and the avoidance hole cooperates with the reagent bottle. The reagent cover is arranged in the middle of the connecting disk, and above the reagent bottle of the reagent cover, and the reagent cover is fixedly connected to the connecting disk.

[0021] As a preferred solution, a heating film is provided under the reaction disk, and insulation pads are provided inside and outside the reaction disk, and optical detection components are provided corresponding to the placement holes of the reaction disk, and the optical detection components are used to detect substances in the reaction cup.

[0022] As a preferred embodiment, a mixing module is provided below the detection module, and the mixing module includes a DC motor, an annular base plate, a plurality of toothed idler wheels, a plurality of followers and a transmission belt. The annular base plate is arranged below the reaction disk, and the DC motor is fixed below the annular base plate. The plurality of toothed idler wheels are rotatably arranged along the surface of the annular base plate, and the toothed idler wheels are arranged corresponding to the through holes on the reaction disk, and the plurality of followers are arranged at intervals between two toothed idler wheels. The output shaft of the DC motor is provided with a driving wheel, and the driving wheel drives the plurality of toothed idler wheels and followers to be connected through a transmission belt, and a pair of mixing magnets with opposite polarities are provided above the toothed idler wheels.

[0023] As a preferred solution, the reagent suction robot arm, the grasping robot arm and the sample suction robot arm have the same structure. The reagent suction robot arm and the sample suction robot arm use reagent needles and sample needles to absorb liquid respectively, and the grasping robot arm uses a clamp to grasp the reaction cup.

[0024] As a preferred embodiment, the sample introduction device includes a sample introduction area, a suction area and a sample output area which are arranged in sequence. The sample introduction area is provided with a tray, which is used to place a plurality of sample racks. The sample racks are pushed to the suction area by a sample pusher. The suction area is located on the rotation track of the sample suction mechanical arm. The sample racks in the suction area are pushed to the sample output area by a sample pusher.

[0025] The beneficial effect of a small-scale fully automatic platelet aggregation instrument disclosed by the present invention is that through a reasonable structural layout, the processes of loading samples and reaction cups, centrifugal treatment of samples, mixing of reagents and samples, sample testing and waste disposal are effectively combined above the frame, so that personnel only need to prepare materials to complete the automated processing of the entire detection step, thereby improving the detection efficiency and saving space at the same time, so that it can better meet the use of laboratories and other links. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0027] Figure 2 The present invention is a schematic diagram of a small-sized fully automatic platelet aggregation instrument with a hood installed.

[0028] Figure 3 It is a top view of a small fully automatic platelet aggregation instrument of the present invention.

[0029] Figure 4 It is a schematic diagram of the horizontal layout of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0030] Figure 5 The present invention is a schematic diagram of the structure of a reaction cup transmission device of a small-sized fully automatic platelet aggregation instrument.

[0031] Figure 6 The present invention is a schematic diagram of the structure of a silo mechanism of a small-sized fully automatic platelet aggregation instrument.

[0032] Figure 7 It is a schematic diagram of the internal structure of a silo mechanism of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0033] Figure 8 The present invention is a schematic diagram of the structure of a stirring bar adding mechanism of a small-scale fully automatic platelet aggregation instrument.

[0034] Fig. 9 The present invention is a cross-sectional view of a stirring bar adding mechanism of a small-scale fully automatic platelet aggregation instrument.

[0035] Fig.10 It is an exploded view of a stirring bar adding mechanism of a small-scale fully automatic platelet aggregation instrument of the present invention.

[0036] Fig.11 It is a structural schematic diagram of a rotation detection device of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0037] Fig.12 It is a schematic diagram of the structure of a rotating module of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0038] Fig.13 It is a schematic diagram of the structure of a reagent disk module of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0039] Fig.14 The utility model is a cross-sectional view of a refrigeration pot of a small-sized fully automatic platelet aggregation instrument of the present invention.

[0040] Fig.15 The present invention is a schematic diagram of a turntable structure of a small-sized fully automatic platelet aggregation instrument.

[0041] Fig.16 It is a schematic diagram of the detection module structure of a small-scale fully automatic platelet aggregation instrument of the present invention.

[0042] Fig.17 It is a schematic diagram of the structure of a mixing module of a small-scale fully automatic platelet aggregation instrument of the present invention.

[0043] Fig.18 The present invention is a schematic diagram of the structure of a sample introduction device of a small-sized fully automatic platelet aggregation instrument. DETAILED DESCRIPTION

[0044] The present invention will be further described and illustrated below in conjunction with specific embodiments and accompanying drawings:

[0045] Please refer to Figure 1 and Figure 2 A small fully automatic platelet aggregation instrument includes a frame 10, a reversible cover 11 is arranged above the frame 10, and a touch screen can be arranged on the surface of the frame 10 for controlling and understanding the working conditions of various internal devices.

[0046] Please refer to Figure 5 The reaction cup transmission device 20 includes a hopper mechanism 21 and a stirring bar adding mechanism 22. The hopper mechanism 21 is used for loading the reaction cup. The stirring bar mechanism is arranged on one side of the hopper mechanism 21. The stirring bar adding mechanism 22 is used for adding the stirring bar into the loaded reaction cup.

[0047] Please refer to Figure 6 and Figure 7 The hopper mechanism 21 includes a first hopper 211 and a material ejecting assembly 212. The material ejecting assembly 212 is arranged inside the first hopper 211. The material ejecting assembly 212 is used to eject a single reaction cup in the first hopper 211. A slide rail 213 is provided on one side of the first hopper 211. The slide rail 213 is formed by two sets of baffles 214 arranged relatively at intervals. The upper end of the slide rail 213 is inclined downward along the upper end of the first hopper 211. The width of the slide rail 213 is greater than the cup body diameter of the reaction cup and less than the cup cover width; a cup pushing mechanism 215 is provided at the lower end of the slide rail 213. The cup pushing mechanism 215 is correspondingly arranged at the lower end of the slide rail 213. The cup pushing mechanism 215 pushes the reaction cup sliding out of the lower end of the slide rail 213 toward the bottom of the stirring bar adding mechanism 22.

[0048] The material ejecting assembly 212 includes a cup selecting rod 2121, an extension sleeve 2122 and a guide rail 2123. A sliding hole is provided below the first hopper 211. The extension sleeve 2122 is slidably arranged in the sliding hole. The cup selecting rod 2121 is arranged in the extension sleeve 2122, and a guide groove is provided on the surface of the extension sleeve 2122. A bolt is fixedly provided at the lower end of the cup selecting rod 2121, and the bolt is slidably arranged in the guide groove. The upper end of the cup selecting rod 2121 is slidably connected to the guide rail 2123 through a support 2124. The guide rail 2123 is fixedly arranged along the extension direction of the first hopper 211, and the bracket slides up and down along the guide rail 2123 through the first moving assembly 2125.

[0049] In order to reduce the length of the first hopper 211 and the cup selection rod 2121, the cup selection rod 2121 and the extension sleeve 2122 are formed into a telescopic structure. When the first moving assembly 2125 drives the cup selection rod 2121 to descend, the cup selection rod 2121 first slides along the extension sleeve 2122, so that the lower end of the cup selection rod 2121 is stored in the extension sleeve 2122. When it continues to descend, the bolt on the cup selection rod 2121 contacts the bottom of the guide groove, and the extension sleeve 2122 is driven from the bottom of the first hopper 211 through the bolt. The cup selecting rod 2121 slides out of the sliding hole, thereby ensuring that the cup selecting rod 2121 can smoothly descend to the bottom of the first hopper 211, and push out the reaction cup at the bottom of the first hopper 211. When the cup selecting rod 2121 rises, the first moving assembly 2125 first drives the cup selecting rod 2121 to slide out of the extension sleeve 2122, and then further uses the bolt to contact the top of the guide groove, thereby pulling the extension sleeve 2122 to slide up in the sliding hole, ensuring that the cup selecting rod 2121 can move to the upper end of the first hopper 211, and push the reaction cup into the slide rail 213.

[0050] The cup pushing assembly includes a mounting plate 2151, a cup pushing rod 2152 and a second movable assembly 2153. The mounting plate 2151 is arranged at the lower end of the slide rail 213, and the mounting plate 2151 is provided with an avoidance hole corresponding to the slide rail 213. The cup pushing rod 2152 is arranged on the side of the mounting plate 2151 away from the slide rail 213. The cup pushing rod 2152 is slidably arranged with the mounting plate 2151 through the second guide rail. The upper end of the cup pushing rod 2152 is arranged in contact with the mounting plate 2151, and the upper end of the cup pushing rod 2152 is provided with a groove corresponding to the reaction cup. The lower end of the cup pushing rod 2152 is fixedly connected to the second movable assembly 2153, and the second movable assembly 2153 drives the cup pushing rod 2152.

[0051] The reaction cup slides out from the lower end of the slide rail 213 and slides into the groove on the cup pushing rod 2152 through the avoidance hole. The groove limits the reaction cup and keeps the reaction cup upright. The reaction cup is then pushed by the second moving component 2153.

[0052] A plurality of reaction cups are directly poured into the first hopper 211 of the hopper assembly, and the reaction cups are ejected one by one in sequence by the ejecting assembly 212 in the first hopper 211, and fall into the slide rail 213. The upper end of the slide rail 213 is tilted downward along the upper end of the first hopper 211, so that the reaction cups slide downward along the slide rail 213 under the action of gravity, and because the width of the slide rail 213 is greater than the cup body diameter of the reaction cup and smaller than the cup cover width, the cup body of the reaction cup falls between the two baffles 214 during the sliding process, and the cup cover is stuck on the baffle 214 and slides, so as to arrange the reaction cups in the same direction. When the reaction cups slide to the lower end of the slide rail 213 in sequence, the reaction cups are pushed out one by one by the cup pushing assembly, so that the reaction cups can be arranged and pushed out in an orderly manner.

[0053] Please refer to Figure 8 , Fig. 9 and Fig.10 The stirring bar used in the stirring bar adding mechanism 22 has magnetism inside, which can be a magnetic bead. The stirring bar adding mechanism 22 includes a second hopper 221 and a pushing mechanism 226. A base 222 and a guide seat 223 are provided inside the second hopper 221. The guide seat 223 is V-shaped and inclined on the side away from the base 222. The guide seat 223 is arranged above the base 222, and there is a gap between the guide seat 223 and the base 222 to form a pushing channel 224. A first through hole 2231 is provided in the middle of the guide seat 223, and the first through hole 2231 is connected to the pushing channel 224. The base A discharge port 2221 is provided on one side of 222, and the discharge port 2221 is connected to the pushing channel 224, and the discharge port 2221 is located correspondingly above the cup pushing mechanism 215. A material suction magnet 2222 is provided on the base 222 corresponding to the first through hole 2231. A push rod 225 is slidably provided in the pushing channel 224. A second through hole 2251 for accommodating a stirring bar is opened at one end of the push rod 225. The second through hole 2251 is arranged at one end close to the discharge port 2221. A pushing mechanism 226 is arranged on one side of the second hopper 221, and the pushing device drives the push rod 225 to slide left and right along the pushing channel 224.

[0054] The reaction cup is sent to the bottom of the discharge port 2221 through the cup pushing mechanism 215, and the stirrer is poured into the hopper at will. Since the guide seat 223 is an inclined surface, the stirrer will slide along the inclined surface to the first through hole 2231 at the bottom. When the second through hole 2251 of the push rod 225 is aligned with the first through hole 2231, the selected stirrer will be sucked into the second through hole 2251 by the material suction magnet 2222 on the base 222, and then the push rod 225 moves toward the side of the discharge port 2221. The second through hole 2251 can only accommodate one stirrer. When the push rod 225 moves, the other stirrers are blocked by the guide seat 223, and the selected stirrer is driven to move together; when the second through hole 2251 is aligned with the discharge port 2221, the selected stirrer will fall from the second through hole 2251 into the discharge port 2221 under the action of gravity, and then fall into the reaction cup below, completing the process of selecting a single stirrer and transmitting a single stirrer.

[0055] The centrifuge 30 is disposed on one side of the rotation detection device 40 , and is used for centrifuging the sample in the reaction cup.

[0056] Please refer to Fig.11, a rotating detection device 40, the rotating detection device 40 includes a rotating module 41, a reagent disk module 42 and a detection module 43, the reagent disk module 42 is fixedly connected to the rotating module 41, the rotating module 41 drives the reagent disk module 42 to rotate, the reagent disk module 42 is used to place a plurality of reagent bottles, the detection module 43 is arranged around the reagent disk module 42, and the detection module 43 is fixedly connected to the reagent disk module 42, and the detection module 43 is used to place a plurality of reaction cups.

[0057] Please refer to Fig.12 The rotating module 41 includes a stepper motor 411, a main shaft 412, a driving pulley 413, a driven pulley 414, a synchronous belt 415 and a support plate 416. The stepper motor 411 is fixed in the frame 10. The output shaft of the stepper motor 411 is provided with a driving pulley 413. One end of the main shaft 412 is fixed under the reagent disk module. The main shaft 412 is rotatably connected to the support plate 416 through a bearing. The support plate 416 is fixedly connected to the frame 10. The driven pulley 414 is arranged at the other end of the main shaft 412. The driving pulley 413 and the driven pulley 414 are transmission connected through a synchronous belt 415.

[0058] Please refer to Figures 13 to 15 The reagent disk module 42 includes a refrigeration pot 421, a semiconductor refrigeration sheet 422, an RFID card reader 423 and a turntable 424. The refrigeration pot 421 is fixedly connected to the frame 10, the RFID card reader 423 is fixed to the inner wall of the refrigeration pot 421, the semiconductor refrigeration sheet 422 is fixed to the bottom of the refrigeration pot 421 corresponding to the RFID card reader 423, and the outer periphery of the refrigeration pot 421 is wrapped with thermal insulation cotton 425, the turntable 424 is rotatably arranged inside the refrigeration pot 421, and the turntable 424 is fixedly connected to one end of the main shaft 412, and a plurality of external gears 426 are provided on the surface of the turntable 424 for rotating around the rear center, and a card hole for placing a reagent bottle is provided above the external gear 426, and an internal gear ring 427 is provided inside the refrigeration pot 421, and the external gear 426 and the internal gear ring 427 are meshed with each other.

[0059] The driving pulley 413 of the stepping motor 411 is rotated, and the driven pulley 414 is rotated through the synchronous belt 415, so that the main shaft 412 is also rotated, driving the reagent disk to rotate, and the outer gear 426 under the reagent bottle is fixed to the inner gear in the refrigeration pot 421 for meshing. When the reagent disk is rotating, the reagent bottle can also rotate around its own axis to mix the reagents in the reagent bottle.

[0060] An RFID tag is attached to the side of the reagent bottle. When the reagent bottle is close to the RFID reader 423, the RFID tag should face the RFID reader 423 to detect the ID information on the RFID tag, and the semiconductor refrigeration sheet 422 cools the refrigeration pot 421. When the reagent disk rotates, the air in the refrigeration pot 421 is stirred, and rapid heat exchange is performed with the pot wall and the reagent bottle, so that the reagent bottle is quickly and evenly cooled, and the reagent bottle is kept within the range of 2 to 8 degrees Celsius, thereby extending the use time of the reagent, and the thermal insulation cotton 425 has the effect of keeping the inside of the refrigeration pot 421 warm.

[0061] Please refer to Fig.16 The detection module 43 includes three reaction disks 431, a connecting disk 432 and a reagent cover 433. The three reaction disks 431 are all arc-shaped structures. The three reaction disks 431 are replaced with a ring structure around the refrigeration pot 421. The reaction disk 431 is provided with a plurality of placement holes for placing reaction cups. The connecting disk 432 is arranged above the reaction disk 431. The connecting disk 432 is used to fix the three reaction disks 431, and the connecting disk 432 is provided with corresponding placement holes and through holes. The connecting disk 432 has an avoidance hole in the middle, and the avoidance hole cooperates with the reagent bottle. The reagent cover 433 is arranged in the middle of the connecting disk 432, and above the reagent bottle of the reagent cover 433, the reagent cover 433 is fixedly connected to the connecting disk 432.

[0062] A heating film 434 is provided below the reaction disk 431 , and heat preservation pads 435 are provided inside and outside the reaction disk 431 , and optical detection components 436 are provided at the corresponding placement holes of the reaction disk 431 , and the optical detection components 436 are used to detect substances in the reaction cup.

[0063] The three reaction disks 431 are integrally fixedly connected via the connecting disk 432, which is fixedly connected to the reagent cover 433. The connecting disk 432 cooperates with the reagent bottle in the reagent disk, so that when the reagent disk drives the reagent bottle to rotate, the reagent bottle also drives the connecting disk 432 to rotate, so that the reaction disk 431 rotates around the main axis 412 together, thereby adjusting the position of the reaction cup on the reaction disk 431.

[0064] The heating film 434 below the reaction disk 431 heats the reaction cup. The inner and outer sides of the reaction disk 431 are attached with insulation pads 435 to reduce heat exchange with the outside. Through heating and insulation, the reaction cup to be tested is kept at 37 degrees Celsius to incubate the liquid in the reaction cup.

[0065] Please refer to Fig.17A mixing module 44 is provided below the detection module 43. The mixing module 44 includes a DC motor 441, an annular bottom plate 442, a plurality of toothed idler wheels 443, a plurality of followers 444 and a transmission belt 445. The annular bottom plate 442 is provided below the reaction disk 431. The DC motor 441 is fixed below the annular bottom plate 442. A plurality of toothed idler wheels 443 are rotatably provided along the surface of the annular bottom plate 442. The toothed idler wheels 443 are provided corresponding to the through holes on the reaction disk 431. A plurality of followers 444 are provided between two toothed idler wheels 443 at intervals. A driving wheel 446 is provided on the output shaft of the DC motor 441. The driving wheel 446 drives a plurality of toothed idler wheels 443 and followers 444 to be transmission-connected through a transmission belt 445. A pair of mixing magnets 447 with opposite polarities is provided above the toothed idler wheels 443.

[0066] The DC motor 441 drives the driving wheel 446 to rotate, and the transmission belt 445 drives a plurality of toothed idler wheels 443 and a follower 444 to rotate. The follower 444 is used to keep the transmission belt 445 taut, so that the mixing magnet 447 on the toothed idler wheel 443 rotates together. The magnetic field of the mixing magnet 447 attracts the stirring bar in the reaction cup to rotate together, and the stirring bar mixes the liquid in the reaction cup.

[0067] The reagent suction robot arm 50 has a rotation track covering the reagent disk module 42 and the detection module 43 of the rotating detection device 40. The reagent suction robot arm 50 is used to suck the reagent in the reagent disk in the rotating detection device 40 and add it to the reaction cup in the detection module 43. The reagent suction robot arm 50 is correspondingly provided with a reagent cleaning tank 51, and the reagent cleaning tank 51 is located on the rotation track of the reagent suction robot arm 50.

[0068] The grabbing robot arm 60 is arranged on one side of the centrifuge 30 , and the rotation track of the grabbing robot arm 60 covers the silo mechanism 21 , the centrifuge 30 and the detection module 43 . The grabbing robot arm 60 is used to grab and transfer the reaction cup on the silo mechanism 21 to the centrifuge 30 and the detection module 43 .

[0069] Please refer to Fig.18 , the sample injection device 70 is located at one side of the rotating detection device 40. The sample injection device 70 is used for placing and delivering sample tubes. A sample suction robot arm 80 is provided between the sample injection device 70 and the rotating detection device 40. The rotation track of the sample suction robot arm 80 covers the sample delivery device, the centrifuge 30 and the detection module 43. The sample suction robot arm 80 is used to suck the sample in the sample tube into the centrifuge 30, and then suck the sample that has been centrifuged by the centrifuge 30 into the detection module 43. The sample suction robot arm 80 is correspondingly provided with a sample cleaning pool 81, and the sample cleaning pool 81 is located on the rotation track of the sample suction robot arm 80.

[0070] The sample introduction device 70 includes a sample introduction area 71, a suction area 72 and a sample outlet area 73 which are arranged in sequence. The sample introduction area 71 is provided with a support plate for placing a plurality of sample racks. The sample racks are pushed to the suction area 72 by a sample pusher 74. The suction area 72 is located on the rotation track of the sample suction mechanical arm 80. The sample racks in the suction area 72 are pushed to the sample outlet area 73 by the sample pusher 74.

[0071] The reagent suction robot arm 50 , the grabbing robot arm 60 and the sample suction robot arm 80 have the same structure. The reagent suction robot arm 50 and the sample suction robot arm 80 use a reagent needle and a sample needle to suck liquid respectively, and the grabbing robot arm 60 uses a clamp to grab the reaction cup.

[0072] The waste bin 90 is located on the rotation track of the grabbing robot arm 60 and is used to collect discarded reaction cups after the test.

[0073] To understand the working status of the whole machine, please refer to Figure 3 and Figure 4 .

[0074] The reagent suction robot arm 50 docks with the reagent disk module 42 at point A, docks with the detection module 43 at point B, and docks with the reagent cleaning pool 51 at point C;

[0075] The grabbing robot arm 60 docks with the silo mechanism 21 at point D, docks with the centrifuge 30 at point E, docks with the detection module 43 at point F, and docks with the waste bin 90 at point G;

[0076] The sample suction robot arm 80 docks with the sample delivery device at point H, docks with the centrifuge 30 at point I, docks with the detection module 43 at point J, and docks with the sample cleaning pool 81 at point K.

[0077] Working principle: the operator turns on the machine through the touch screen and checks whether the current consumables (reaction cup, stirring bar) are in a fully loaded state. If not, a sufficient number of reaction cups are put into the corresponding reaction cup compartment and a sufficient number of magnetic beads are put into the corresponding magnetic bead compartment. If it is full, no further operation is required; check whether the reagent in the rotating detection device 40 has been consumed. If there is a vacancy, the operator needs to manually add a reagent bottle with the reagent to the reagent tray module 42. If the amount of reagent is sufficient, no further operation is required; check whether the medical waste in the waste bin 90 is full. If it is nearly full, the waste needs to be dumped out and re-bagged. If the trash can is relatively empty, no further operation is required.

[0078] When the consumables are ready, fill the test tube rack with sample tubes, and then the sample rack is automatically transported in the machine. When the sample rack is transported to the corresponding point H, the sample suction robot 80 intervenes to suck about a certain amount of sample from the sample tube and transfer the sample to the corresponding point I of the centrifuge 30. The sample suction robot 80 cleans the sample in the corresponding point K of the sample cleaning pool 81. After that, the sample rack is automatically fed a distance of the sample tube spacing under the action of the sample pusher 74. The sample suction robot 80 repeats the above operation. The centrifuge 30 is started when the dynamic balance is met, and the centrifugal action of the sample tube is performed for a certain period of time; at the same time, the cup grabbing arm assembly will transfer the empty reaction cup from the corresponding point D of the hopper mechanism 21 to the centrifuge 30 in sequence until it is full; then the cup grabbing arm assembly will transfer the reaction cup with the stirrer from the corresponding point D to the centrifuge 30 in sequence. The corresponding point B of the detection module 43 is filled; the sample rack that has just been sucked will be pushed horizontally to the sample outlet area 73 of the injection assembly, and the sample outlet pusher will push the sample rack to slide out in the vertical direction; the sample suction robot 80 will transfer the centrifuged sample at the corresponding point H to the point I in the detection module 43, the rotating detection device 40 will rotate a certain angle, and the reagent robot will suck the quantitative reagent from the point A of the reagent disk module 42 and transfer it to the corresponding point B of the detection module 43. After the transfer is completed, the reagent suction robot 50 will be transferred to the point C for cleaning and perform the self-cleaning operation of the reagent needle. Then the rotating detection device 40 will perform a mixing operation on the reagent, stirrer and sample in the reaction cup, and then perform optical detection and analysis on them; the detected reaction cup and its waste residue will be transferred from the cup bead loading / unloading position to the waste bin 90 by the cup grabbing arm assembly.

[0079] At this point, the machine completes the automatic injection, discharge, shaking, centrifugation and detection of samples, the refrigeration, mixing and automatic loading of reagents, the automatic supply and recovery of reaction cups and stirrers, the suction / discharge and self-cleaning of reagent needles / sample needles and other functions, and the reasonable structural design and layout. In theory, the above process can carry out multiple processes at the same time and detect multiple samples at the same time, so the detection speed will be greatly improved.

[0080] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A small fully automatic platelet aggregation instrument, characterized in that: Including rack; A reaction cup transmission device, the reaction cup transmission device comprising a silo mechanism and a stirring bar adding mechanism, the silo mechanism is used for loading the reaction cup, the stirring bar mechanism is arranged on one side of the silo mechanism, and the stirring bar adding mechanism is used for adding the stirring bar into the loaded reaction cup; A centrifuge, which is arranged on one side of the rotating detection device and is used to centrifuge the sample in the reaction cup; A rotation detection device, the rotation detection device comprises a rotating module, a reagent disk module and a detection module, the reagent disk module is fixedly connected to the rotating module, the rotating module drives the reagent disk module to rotate, the reagent disk module is used to place a plurality of reagent bottles, the detection module is arranged around the reagent disk module, and the detection module is fixedly connected to the reagent disk module, and the detection module is used to place a plurality of reaction cups; A reagent suction mechanical arm, the rotation track of which covers the reagent disk module and the detection module of the rotating detection device, the reagent suction mechanical arm is used to suck the reagent in the reagent disk in the rotating detection device and add it to the reaction cup in the detection module, and the reagent suction mechanical arm is correspondingly provided with a reagent cleaning pool, and the reagent cleaning pool is located on the rotation track of the reagent suction mechanical arm; A grabbing robot arm, which is arranged on one side of the centrifuge, and whose rotation track covers the silo mechanism, the centrifuge and the detection module, and is used to grab and transfer the reaction cup on the silo mechanism to the centrifuge and the detection module; A sample introduction device, the sample introduction device is located on one side of the rotating detection device, the sample introduction device is used for placing and delivering samples to the sample tube, a sample suction mechanical arm is provided between the sample introduction device and the rotating detection device, the rotation track of the sample suction mechanical arm covers the sample delivery device and the detection module, the sample suction mechanical arm is used to suck the sample in the sample tube and add it to the detection module, the sample suction mechanical arm is correspondingly provided with a sample cleaning pool, and the sample cleaning pool is located on the rotation track of the sample suction mechanical arm; A waste bin is located on the rotation track of the grabbing robot arm, and is used to collect discarded reaction cups after the test is completed.

2. A small fully automatic platelet aggregation instrument as claimed in claim 1, characterized in that: The hopper mechanism includes a first hopper and a material ejecting assembly, the material ejecting assembly is arranged inside the first hopper, and the material ejecting assembly is used to eject a reaction cup in the first hopper individually. A slide rail is provided on one side of the first hopper, and the slide rail is formed by two groups of baffles arranged relatively and spaced apart. The upper end of the slide rail is inclined downward along the upper end of the first hopper, and the width of the slide rail is greater than the cup body diameter of the reaction cup and less than the cup cover width; a cup pushing mechanism is provided at the lower end of the slide rail, and the cup pushing mechanism is correspondingly arranged at the lower end of the slide rail, and the cup pushing mechanism pushes the reaction cup that slides out of the lower end of the slide rail toward the bottom of the stirring bar adding mechanism.

3. A small fully automatic platelet aggregation instrument as claimed in claim 2, characterized in that: The stirring bar adding mechanism includes a second hopper and a pushing mechanism, a base and a guide seat are provided inside the second hopper, the guide seat is in a V-shaped inclined structure on the side away from the base, the guide seat is arranged above the base, and there is a gap between the guide seat and the base to form a pushing channel, and a first through hole is provided in the middle of the guide seat, the first through hole is connected to the pushing channel, a discharge port is provided on one side of the base, the discharge port is connected to the pushing channel, and the discharge port is located above the pushing cup mechanism correspondingly, the base is provided with a first magnet corresponding to the first through hole, a push rod is slidably provided in the pushing channel, a second through hole for accommodating the stirring bar is opened at one end of the push rod, and the second through hole is arranged at one end close to the discharge port, the pushing mechanism is arranged on one side of the second hopper, and the pushing device drives the push rod to slide left and right along the pushing channel.

4. A small fully automatic platelet aggregation instrument as claimed in claim 1, characterized in that: The rotating module includes a stepper motor, a main shaft, a driving pulley, a driven pulley, a synchronous belt and a support plate. The stepper motor is fixed in a frame. The output shaft of the stepper motor is provided with a driving pulley. One end of the main shaft is fixed under the reagent disk module. The main shaft is rotatably connected to the support plate through a bearing. The support plate is fixedly connected to the frame. The driven pulley is arranged at the other end of the main shaft. The driving pulley and the driven pulley are transmission connected through a synchronous belt.

5. A small fully automatic platelet aggregation instrument as claimed in claim 4, characterized in that: The reagent disk module includes a refrigeration pot, a semiconductor refrigeration sheet, an RFID card reader and a turntable. The refrigeration pot is fixedly connected to the frame, the RFID card reader is fixed to the inner wall of the refrigeration pot, the semiconductor refrigeration sheet is fixed to the bottom of the refrigeration pot corresponding to the RFID card reader, and the outer periphery of the refrigeration pot is wrapped with thermal insulation cotton. The turntable is rotatably arranged inside the refrigeration pot, and the turntable is fixedly connected to one end of the main shaft. A plurality of external gears are provided on the surface of the turntable for rotation around the rear center, and a card hole for placing a reagent bottle is provided above the external gear. An internal gear ring is provided inside the refrigeration pot, and the external gear and the internal gear ring are meshed with each other.

6. A small fully automatic platelet aggregation instrument as claimed in claim 5, characterized in that: The detection module includes three reaction disks, a connecting disk and a reagent cover. The three reaction disks are all arc-shaped structures. The three reaction disks are replaced with a ring structure around the refrigeration pot. The reaction disk is provided with a plurality of placement holes for placing reaction cups. The connecting disk is arranged above the reaction disk. The connecting disk is used to fix the three reaction disks, and the connecting disk is provided with corresponding placement holes and through holes. The connecting disk has an avoidance hole in the middle, and the avoidance hole cooperates with the reagent bottle. The reagent cover is arranged in the middle of the connecting disk and above the reagent bottle of the reagent cover. The reagent cover is fixedly connected to the connecting disk.

7. A small fully automatic platelet aggregation instrument as claimed in claim 6, characterized in that: A heating film is arranged below the reaction disk, and heat preservation pads are arranged inside and outside the reaction disk. Optical detection components are arranged at the corresponding placement holes of the reaction disk, and the optical detection components are used to detect substances in the reaction cup.

8. A small fully automatic platelet aggregation instrument as claimed in claim 7, characterized in that: A mixing module is provided below the detection module, and the mixing module includes a DC motor, an annular base plate, a plurality of toothed idler wheels, a plurality of followers and a transmission belt. The annular base plate is provided below the reaction disk, and the DC motor is fixed below the annular base plate. The plurality of toothed idler wheels are rotatably provided along the surface of the annular base plate, and the toothed idler wheels are provided corresponding to the through holes on the reaction disk, and the plurality of followers are provided at intervals between two toothed idler wheels. A driving wheel is provided on the output shaft of the DC motor, and the driving wheel drives the plurality of toothed idler wheels and followers to be transmission-connected through a transmission belt, and a pair of mixing magnets with opposite polarities are provided above the toothed idler wheels.

9. A small fully automatic platelet aggregation instrument as claimed in claim 1, characterized in that: The reagent suction mechanical arm, the grasping mechanical arm and the sample suction mechanical arm have the same structure. The reagent suction mechanical arm and the sample suction mechanical arm respectively use a reagent needle and a sample needle to absorb liquid, and the grasping mechanical arm uses a clamp to grasp the reaction cup.

10. A small fully automatic platelet aggregation instrument as claimed in claim 1, characterized in that: The sample introduction device comprises a sample introduction area, a suction area and a sample output area which are arranged in sequence. The sample introduction area is provided with a support plate, which is used to place a plurality of sample racks. The sample racks are pushed to the suction area by a sample pusher. The suction area is located on the rotation track of the sample suction mechanical arm. The sample racks in the suction area are pushed to the sample output area by the sample pusher.

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