Fullerene C60 eye fatigue relieving patch and preparation method thereof

Abstract

The invention discloses a fullerene C60 eye fatigue relieving patch and a preparation method thereof, and belongs to the technical field of eye patches. The fullerene C60 eye fatigue relieving patch comprises hydrogel and a non-woven fabric, the hydrogel is prepared from the following raw materials: a traditional Chinese medicine active substance, fullerene and a gelling substance. The fullerene C60 eye fatigue relieving patch is in a hydrogel dosage form, fullerene is further added, and the product is good in moisturizing performance, good in sterilization performance and good in mechanical strength performance.

Description

Technical Field

[0001] The invention belongs to the technical field of eye patches, and in particular relates to a fullerene C60 eye fatigue relieving patch and a preparation method thereof. Background Art

[0002] Eye patches are a common product used to relieve eye fatigue. They usually contain cooling ingredients such as mint, cucumber extract, etc., which can help reduce tension and fatigue around the eyes. When used, they can provide a cool and relaxing feeling to the eyes, helping to relieve dry eyes, redness, and fatigue caused by prolonged use of electronic screens or reading. Eye patches work mainly through a physical cooling effect to reduce eye discomfort. They can also help the eyes rest by blocking light, especially when they need to take a nap or relax. In addition, some eye patches may contain vitamins and antioxidants, which help protect the eyes from free radical damage and promote eye health.

[0003] The existing eye patches with Chinese medicinal materials as active ingredients have poor sterilization effects, and the thin films formed with glycerol as the matrix have poor moisturizing properties.

[0004] Fullerene C60, also known as buckyballs because of its structure similar to a traditional English soccer ball. Fullerene has some unique physical and chemical properties, which has led to its wide application in a variety of fields. The role of fullerene in cosmetics is mainly due to its unique physical and chemical properties. As a powerful antioxidant, fullerene is able to absorb free radicals, thereby protecting skin cells from oxidative stress. Free radicals are one of the main causes of skin aging, spots and wrinkles, so the antioxidant properties of fullerene make it a star ingredient in anti-aging cosmetics. In addition, fullerene has anti-inflammatory effects and helps reduce skin redness and inflammation, which is especially important for the care of sensitive skin or skin prone to inflammation. It is also able to absorb ultraviolet rays and provide a certain degree of sun protection for the skin. Although it is not usually used as the main sunscreen ingredient, it can be used as a supplementary ingredient to enhance the sunscreen effect. In cosmetic formulations, fullerenes are usually present in the form of nanoparticles, which allows them to more easily penetrate the surface of the skin and exert their antioxidant and anti-inflammatory effects. Summary of the invention

[0005] In view of the above problems of low sterilization rate and poor moisturizing property, the present invention proposes a gel-type eye patch and attempts to add fullerene into the eye patch to improve the performance of the eye patch.

[0006] The first aspect of the present invention is to disclose a fullerene C60 eye fatigue relief patch, comprising a hydrogel and a non-woven fabric;

[0007] The raw materials for preparing the hydrogel include traditional Chinese medicine active substances, fullerene and gel-forming substances.

[0008] In some embodiments of the present invention, the raw materials for preparing the active substance of traditional Chinese medicine are aqueous extracts of chrysanthemum, white peony root, phellodendron, cassia bark and liquorice, and borneol;

[0009] Or, the raw materials for preparing the active Chinese medicine substance are aqueous extracts of chrysanthemum, white peony root, phellodendron, cassia bark and liquorice, borneol and tea polyphenols.

[0010] In some embodiments of the present invention, the preparation method of the aqueous extract of chrysanthemum, white peony root, phellodendron, sesame and licorice is to take the raw materials, mix, crush, add deionized water, decoct, filter, repeat the decoction of the residue 1-3 times, filter, and combine the filtrate.

[0011] In some embodiments of the present invention, the gel-forming substance includes carrageenan and CaCl2.

[0012] In some embodiments of the present invention, the hydrogel is prepared by mixing the aqueous extract with borneol, a fullerene mixed solution, and a gel-forming substance;

[0013] Alternatively, the hydrogel is prepared by mixing the aqueous extract with borneol, tea polyphenols, a fullerene mixed solution, a gel-forming substance, and deionized water.

[0014] In some embodiments of the present invention, each 100 mL of the hydrogel comprises:

[0015] (1) Borneol 0.2-1g, Fullerene C60 1-10mg;

[0016] (2) water extract of chrysanthemum 1-10g, white peony root 1-5g, phellodendron 0.1-5g, cassia bark 0.1-5g, and liquorice 0.1-3g;

[0017] (3) carrageenan 0.1-5 g and CaCl2 2-8 g;

[0018] (4) The balance is deionized water;

[0019] Preferably:

[0020] (1) Borneol 0.4-0.5 g, Fullerene C60 5-10 mg;

[0021] (2) water extract of chrysanthemum 4-7g, white peony root 2-3g, phellodendron 0.5-1.5g, cassia bark 1.5-2g, and liquorice 0.5-1.5g;

[0022] (3) Carrageenan 0.5-1.5g and CaCl2 4-6g

[0023] (4) The balance is deionized water.

[0024] In some embodiments of the present invention, each 100 mL of the hydrogel comprises:

[0025] (1) Borneol 0.2-1g, tea polyphenols 0.05-0.5g, fullerene C60 1-10mg;

[0026] (2) water extract of chrysanthemum 1-10g, white peony root 1-5g, phellodendron 0.1-5g, cassia bark 0.1-5g, and liquorice 0.1-3g;

[0027] (3) carrageenan 0.6-5 g and CaCl2 2-8 g;

[0028] (4) The balance is deionized water;

[0029] Preferably, it includes:

[0030] (1) Borneol 0.4-0.5g, tea polyphenols 0.1-0.2g, fullerene C60 5-10mg;

[0031] (2) water extract of chrysanthemum 4-7g, white peony root 2-3g, phellodendron 0.5-1.5g, cassia bark 1.5-2g, and liquorice 0.5-1.5g;

[0032] (3) Carrageenan 0.6-1.5g and CaCl2 4-6g

[0033] (4) The balance is deionized water.

[0034] In some embodiments of the present invention, the pH of the hydrogel system is between 5.5-7.5.

[0035] In some embodiments of the present invention, the pH of the hydrogel system is ≤ 6.5, preferably pH ≤ 6.0.

[0036] The second aspect of the present invention is to disclose a method for preparing the fullerene C60 eye fatigue relieving patch described in the first aspect, characterized in that it comprises the following steps:

[0037] S01, take borneol and fullerene, add anhydrous ethanol, stir, mix, and set aside;

[0038] Or, S01, taking borneol, tea polyphenols and fullerene, adding anhydrous ethanol, stirring, mixing, and setting aside;

[0039] and,

[0040] S02, mixing chrysanthemum, white peony root, phellodendron, cassia bark and liquorice, crushing, adding deionized water, decocting, filtering, repeating the decocting of the residue 0-3 times, filtering, combining the filtrate and concentrating;

[0041] S03, heating, adding carrageenan, stirring, and mixing;

[0042] S04, add CaCl2, stir and mix, add the borneol fullerene mixed solution obtained in S01, make up to volume with deionized water, stir and mix;

[0043] S05, vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature to obtain the fullerene C60 eye fatigue relief patch.

[0044] In some embodiments of the present invention, in S02, chrysanthemum, white peony root, phellodendron, cassia bark and licorice are mixed, crushed, added with 8-12 times of deionized water, decocted at 70-95°C for 0.5-1.5 hours, filtered, the residue is decocted repeatedly 1-2 times, filtered, the filtrate is combined and concentrated.

[0045] In some embodiments of the present invention, in S03, heating is performed to 80-95°C.

[0046] In some embodiments of the present invention, in S05, the mixture is allowed to stand at room temperature for 3-5 hours.

[0047] Beneficial effects:

[0048] The fullerene C60 eye fatigue relieving patch of the present invention is a hydrogel dosage form, and fullerene is added. The product has good moisturizing performance, good bactericidal performance, and good mechanical strength performance.

[0049] The preparation method of the fullerene C60 eye fatigue relieving patch of the present invention is simple and quick, and does not require volatile organic solvents and large-scale equipment. DETAILED DESCRIPTION

[0050] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0051] Unless otherwise specified, the examples and comparative examples are parallel tests with the same components, component contents, preparation steps, preparation parameters, dimensions, etc. The fullerene is a water-soluble fullerene, i.e., a hydroxylated derivative.

[0052] Example 1

[0053] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0054] (1) Take 0.5 g of borneol and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0055] (2) Mix 5 g of chrysanthemum, 3 g of white peony root, 1.5 g of phellodendron, 1.5 g of sesame and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0056] (3) Heat to 85°C, add 1 g of carrageenan, stir and mix well;

[0057] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0058] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0059] Example 2

[0060] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0061] (1) Take 0.4 g of borneol and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0062] (2) Mix 4 g of chrysanthemum, 3 g of white peony root, 1.5 g of phellodendron, 2 g of cassia bark and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0063] (3) Heat to 85°C, add 1 g of carrageenan, stir and mix well;

[0064] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0065] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0066] Example 3

[0067] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0068] (1) Take 0.5 g of borneol and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0069] (2) Mix 7 g of chrysanthemum, 2 g of white peony root, 0.5 g of phellodendron, 1.5 g of sesame and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0070] (3) Heat to 85°C, add 1 g of carrageenan, stir and mix well;

[0071] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0072] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0073] Example 4

[0074] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0075] (1) Take 0.5 g of borneol, 0.1 g of tea polyphenols and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0076] (2) Mix 5 g of chrysanthemum, 3 g of white peony root, 1.5 g of phellodendron, 1.5 g of sesame and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0077] (3) Heat to 85°C, add 1 g of carrageenan, stir and mix well;

[0078] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0079] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0080] Example 5

[0081] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0082] (1) Take 0.5 g of borneol, 0.2 g of tea polyphenols and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0083] (2) Mix 5 g of chrysanthemum, 3 g of white peony root, 1.5 g of phellodendron, 1.5 g of sesame and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0084] (3) Heat to 85°C, add 1 g of carrageenan, stir and mix well;

[0085] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0086] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0087] Example 6

[0088] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0089] (1) Take 0.5 g of borneol, 0.1 g of tea polyphenols and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0090] (2) Mix 5 g of chrysanthemum, 3 g of white peony root, 1.5 g of phellodendron, 1.5 g of sesame and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0091] (3) Heat to 85°C, add 1.5 g of carrageenan, stir and mix well;

[0092] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0093] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0094] Example 6

[0095] A method for preparing a fullerene C60 eye fatigue relief patch comprises the following steps:

[0096] (1) Take 0.5 g of borneol, 0.1 g of tea polyphenols and 8 mg of fullerene C60, add 5 ml of anhydrous ethanol, stir, mix well, and set aside;

[0097] (2) Mix 5 g of chrysanthemum, 3 g of white peony root, 1.5 g of phellodendron, 1.5 g of sesame and 1 g of liquorice, grind them, add 100 ml of deionized water, boil them at 85 °C for 1 hour, filter, boil the residues again, filter, combine the filtrate and concentrate to 90 ml;

[0098] (3) Heat to 85°C, add 1.5 g of carrageenan, stir and mix well;

[0099] (4) Add 5 g of CaCl2, stir and mix well, add the borneol fullerene mixed solution from (1), dilute to 100 mL with deionized water, stir and mix well;

[0100] (5) Vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature for 4 h to obtain a gel patch with a thickness of 1 mm, a length of 150 mm, and a width of 50 mm.

[0101] Comparative Example 1

[0102] The difference from Example 1 is that in (1), fullerene C60 is not added.

[0103] Comparative Example 2

[0104] The difference from Example 1 is that step (2) is not included and deionized water is directly used in step (3).

[0105] Comparative Example 3

[0106] The difference from Example 4 is that 0.3 g of carrageenan is added in (3) and 1 g of CaCl2 is added in (4).

[0107] Performance test bactericidal performance

[0108] The gel patches of Examples 1-3 and Comparative Examples 1 and 2 were subjected to sterilization test according to the detection method in Appendix C of "GB15979-2002 Hygiene Standard for Disposable Hygiene Products". The results showed that the sterilization rates of Staphylococcus aureus and Candida albicans of the gel patches of Examples 1-3 were higher than 95%. The sterilization rates of the gel patches of Comparative Examples 1 and 2 were both lower than 90%.

[0109] The gel patches of Examples 1-3 and Comparative Examples 1 and 2 have good mechanical strength when used, are not easily broken or shattered, and have good moisturizing properties.

[0110] Performance testing accelerates stable performance

[0111] The gel patches of Examples 1 and 4-6 and Comparative Example 3 were subjected to stability testing according to the testing method in Appendix C of "GB15979-2002 Hygienic Standard for Disposable Hygienic Products", and accelerated testing in a 54°C constant temperature box for 14 days.

[0112] The results showed that the gel patch of Example 1 had a sterilization rate of 93% and 88% for Staphylococcus aureus and Candida albicans, respectively. The gel patches of Examples 4 and 5 had a sterilization rate of Staphylococcus aureus comparable to that of Example 1, but a sterilization rate of Candida albicans higher than 92%, significantly higher than that of Example 1.

[0113] Example 6 even achieved a sterilization rate of more than 94% for Staphylococcus aureus and Candida albicans. The mechanical strength of the gel patch of Comparative Example 3 was significantly reduced, and the sterilization rates of Staphylococcus aureus and Candida albicans were not significantly different from those of Example 4. This shows that the addition of tea polyphenols can significantly improve the stability of the fullerene C60 eye fatigue relief patch of the present invention, and this improvement is also related to the strength of the eye patch. If the strength is too low, the stability improvement effect is not obvious.

[0114] In addition, it was found that after adding tea polyphenols, in the accelerated test, when the pH of the entire hydrogel system was higher than 6.0, although it did not affect the sterilization rate and accelerated sterilization stability of the product, the color of some hydrogels would change slightly. Especially when it was higher than 6.5, the color change was more obvious and visible to the naked eye.

[0115] The preferred specific implementation modes and embodiments of the present invention are described in detail above, but the present invention is not limited to the above implementation modes and embodiments, and various changes can be made within the knowledge scope of those skilled in the art without departing from the concept of the present invention.

Claims

1. A fullerene C60 eye fatigue relief patch, characterized in that: including hydrogels and nonwoven fabrics; The raw materials for preparing the hydrogel include traditional Chinese medicine active substances, fullerene and gel-forming substances.

2. The fullerene C60 eye fatigue relief patch according to claim 1, characterized in that: The raw materials for preparing the active substance of traditional Chinese medicine are aqueous extracts of chrysanthemum, white peony root, phellodendron, cassia bark and liquorice, and borneol; Or, the raw materials for preparing the active Chinese medicine substance are aqueous extracts of chrysanthemum, white peony root, phellodendron, cassia bark and liquorice, borneol and tea polyphenols.

3. The fullerene C60 eye fatigue relief patch according to claim 1 or 2, characterized in that: The preparation method of the aqueous extract of chrysanthemum, white peony root, phellodendron, cassia bark and liquorice comprises the following steps: taking the raw materials, mixing, crushing, adding deionized water, decocting, filtering, repeatedly decocting the residues for 1-3 times, filtering and combining the filtrate.

4. The fullerene C60 eye fatigue relief patch according to any one of claims 1 to 3, characterized in that: The gelling substances include carrageenan and CaCl2.

5. The fullerene C60 eye fatigue relief patch according to any one of claims 1 to 4, characterized in that: The preparation method of the hydrogel is to mix the aqueous extract with borneol, a fullerene mixed solution, and a gel-forming substance; Alternatively, the hydrogel is prepared by mixing the aqueous extract with borneol, tea polyphenols, a fullerene mixed solution, a gel-forming substance, and deionized water.

6. The fullerene C60 eye fatigue relief patch according to any one of claims 1 to 5, characterized in that: Each 100 mL of the hydrogel comprises: (1) Borneol 0.2-1g, Fullerene C60 1-10mg; (2) water extract of chrysanthemum 1-10g, white peony root 1-5g, phellodendron 0.1-5g, cassia bark 0.1-5g, and liquorice 0.1-3g; (3) carrageenan 0.1-5 g and CaCl2 2-8 g; (4) The balance is deionized water; Preferably: (1) Borneol 0.4-0.5 g, Fullerene C60 5-10 mg; (2) water extract of chrysanthemum 4-7g, white peony root 2-3g, phellodendron 0.5-1.5g, cassia bark 1.5-2g, and liquorice 0.5-1.5g; (3) Carrageenan 0.5-1.5g and CaCl2 4-6g (4) The balance is deionized water.

7. The fullerene C60 eye fatigue relief patch according to any one of claims 1 to 6, characterized in that: Each 100 mL of the hydrogel comprises: (1) Borneol 0.2-1g, tea polyphenols 0.05-0.5g, fullerene C60 1-10mg; (2) water extract of chrysanthemum 1-10g, white peony root 1-5g, phellodendron 0.1-5g, cassia bark 0.1-5g, and liquorice 0.1-3g; (3) carrageenan 0.6-5 g and CaCl2 2-8 g; (4) The balance is deionized water; Preferably, it includes: (1) Borneol 0.4-0.5g, tea polyphenols 0.1-0.2g, fullerene C60 5-10mg; (2) water extract of chrysanthemum 4-7g, white peony root 2-3g, phellodendron 0.5-1.5g, cassia bark 1.5-2g, and liquorice 0.5-1.5g; (3) carrageenan 0.6-1.5 g and CaCl2 4-6 g; (4) The balance is deionized water.

8. A method for preparing the fullerene C60 eye fatigue relief patch according to any one of claims 1 to 7, characterized in that: The following steps are involved: S01, take borneol and fullerene, add anhydrous ethanol, stir, mix, and set aside; Or, S01, taking borneol, tea polyphenols and fullerene, adding anhydrous ethanol, stirring, mixing, and setting aside; and, S02, mixing chrysanthemum, white peony root, phellodendron, cassia bark and liquorice, crushing, adding deionized water, decocting, filtering, repeating the decocting of the residue 0-3 times, filtering, combining the filtrate and concentrating; S03, heating, adding carrageenan, stirring, and mixing; S04, add CaCl2, stir and mix, add the borneol fullerene mixed solution obtained in S01, make up to volume with deionized water, stir and mix; S05, vacuum degassing, injection molding, covering with medical non-woven fabric, and standing at room temperature to obtain the fullerene C60 eye fatigue relief patch.

9. The method for preparing the fullerene C60 eye fatigue relieving patch according to claim 8, characterized in that: In S02, chrysanthemum, white peony root, phellodendron, cassia bark and licorice are mixed, crushed, added with 8-12 times of deionized water, decocted at 70-95°C for 0.5-1.5 hours, filtered, and the dregs are decocted repeatedly for 1-2 times, filtered, and the filtrate is combined and concentrated.

10. The method for preparing the fullerene C60 eye fatigue relieving patch according to claim 8 or 9, characterized in that: In S03, heat to 80-95°C.