Traditional Chinese medicine composition for treating genital herpes and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating herpes progenitalis and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of cicada slough, 10-30 parts of honeysuckle, 20-80 parts of semen cuscutae, 10-50 parts of fructus kochiae and 10-40 parts of fructus forsythiae. After being decocted into a decoction according to the proportion, the traditional Chinese medicine composition is used for spraying or smearing and has an unexpected treatment effect on genital herpes and postherpetic neuralgia of genital herpes.

Description

Technical Field

[0001] The invention belongs to the field of Chinese medicine compositions, and particularly relates to a Chinese medicine composition for treating genital herpes and a preparation method thereof. Background Art

[0002] Genital herpes is the most common and headache-inducing disease in dermatology. Its incubation period is generally 7-10 days. During this period, patients will feel a little uncomfortable. Some patients will experience headaches, fatigue, muscle aches all over the body, and may also have fever symptoms, just like a cold. At the same time, the lymph nodes in the groin may also be slightly swollen. After the incubation period, red spots, red spots, granules, bumps, or small blisters may appear in the genital area, but these small blisters are very thin and will itch. When people can't help it, they want to scratch. The small papules and bumps on the genitals may also become small blisters. Sometimes herpes will break on its own and then form ulcers. At this time, the patient will feel obvious pain, such as needle-like, burning pain and other symptoms. Local lymph node enlargement may also occur, and even secretions may flow out of the urethra. Clusters of small blisters appear around the female external genitalia or anus. There is a transparent or slightly yellow liquid in the blisters. After the small blisters break, erosions or ulcers are formed. It is the same disease as male genital herpes.

[0003] Once a patient develops genital herpes, it will affect all aspects of life, work, rest, exercise, etc. Genital herpes is a disease caused by herpes simplex virus infection, which is easy to relapse. The biggest feature is that it occurs more than 5 times a year.

[0004] Traditional Chinese medicine has unique advantages in treating genital herpes. By regulating the body's environment, it can enhance people's immunity, effectively control the disease, and reduce recurrence. For genital herpes, early detection and early treatment are the best. Therefore, once red spots, bumps, and small blisters are found in the genital area, they should be treated in time.

[0005] However, up to now, there is still no specialized medicine on the market that is effective for genital herpes and can prevent recurrence. Summary of the invention

[0006] All references mentioned herein are incorporated herein by reference. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. Unless otherwise specified, the techniques used or mentioned herein are standard techniques known to one of ordinary skill in the art. Materials, methods, and examples are for illustrative purposes only and are not intended to be limiting.

[0007] In order to solve the problems existing in the above-mentioned prior art, the present invention provides a Chinese medicine composition spray for genital herpes. After practical verification, it is the most effective spray at present, and it also has the special effect of preventing the recurrence of genital herpes. In clinical practice, it has achieved satisfactory results for patients.

[0008] In one embodiment of the present invention, the Chinese medicine composition for treating genital herpes includes: cicada shells, honeysuckle, and dodder seeds.

[0009] In a preferred embodiment of the present invention, the Chinese medicine composition for treating genital herpes comprises the following raw materials in parts by weight: 10-30 parts of cicada shells, 10-30 parts of honeysuckle, and 20-80 parts of dodder seeds.

[0010] Optionally, the composition of the present invention further comprises 10-50 parts of Kochia scoparia seeds on the basis of the above composition. On the basis of treating genital herpes, the composition can better treat the itching and pain caused by genital herpes.

[0011] Optionally, the Chinese medicine composition of the present invention further comprises 10-40 parts of Lianzhao on the basis of the above composition, which can better treat erosion and ulcer of genital herpes on the basis of treating genital herpes.

[0012] Optionally, the Chinese medicine composition for treating genital acne is prepared from the following Chinese medicines in parts by weight:

[0013] Lian Zhao 20-30 parts, Kochia scoparia seeds 30-40 parts, Honeysuckle 20-30 parts, Cuscuta seeds 50-80 parts, and cicada shells 15-20 parts.

[0014] The Chinese medicine composition with the above ratio has a therapeutic effective ratio of up to 80%-96.5%, and has magical and unexpected technical effects in the field of treating genital herpes.

[0015] Optionally, the Chinese medicine composition is an external preparation, including creams, ointments, powders, sprays, etc.,

[0016] Optionally, the present invention also provides a method for preparing a Chinese medicine composition for treating genital herpes, simple oral herpes, and herpetic pharyngitis in children, comprising the following steps:

[0017] (1) Selecting Chinese medicine raw materials, the color and texture of Chinese medicines, the brightness of the texture, the water content, whether they are infested with insects or poison, and the quality of the origin are strictly screened;

[0018] (2) Separate and sieve out impurities from Lian Zhao, Kochia scoparia, honeysuckle, Cuscuta chinensis, and Periostracum cicadae to ensure the quality of Chinese medicines. The high standards and strict requirements must be met. Put Cuscuta chinensis into an iron pan and stir-fry over low heat until it turns slightly yellow, then pour out and let dry;

[0019] (3) Mix the above Chinese medicines according to the ratio, pour into an iron or aluminum pot, add 1000 ml of water and soak for 1 hour;

[0020] (4) After soaking for 1 hour, start to boil the liquid medicine over high heat. After boiling, simmer over low heat for 30 minutes. After boiling, filter out about 100-150ml of the liquid medicine with sterile gauze. Cool it and filter it again with sterile gauze. Put it into a sterile bottle for later use.

[0021] The common pharmacological effects of the Chinese medicinal materials selected in the present invention in this field are as follows:

[0022] Cuscuta chinensis: It is the fruit of the Convolvulaceae plant, the dried mature seeds of Cuscuta chinensis, or Cuscuta chinensis. Nature and flavor: pungent, sweet, neutral. It is used for impotence, spermatorrhea, diarrhea, back and knee pain, tinnitus and kidney deficiency.

[0023] Honeysuckle: The flower buds of the Caprifoliaceae family are sweet and cold in nature, and can clear away heat and detoxify, cool blood, dispel wind-heat, itchy sores and swelling, damp-heat dysentery, and exogenous wind-heat. It has a strong bactericidal effect on influenza virus and various bacteria, especially pyogenic cocci.

[0024] Lian Zhao: Also known as Lian Qiao, it is the dried fruit of the plant Lian Qiao of the Oleaceae family. Lian Zhao, as a traditional Chinese medicine, has the effects of clearing away heat and detoxifying, reducing swelling and dispersing knots, and evacuating wind-heat. It is often used to treat the initial stage of febrile disease, high fever and thirst, scrofula, erysipelas, carbuncle and other symptoms.

[0025] Kochia scoparia: the dried mature fruit of Kochia scoparia (L.) Schrad., a plant of the Chenopodiaceae family. It is used for painful urination, vaginal itching and leucorrhea, urticaria, eczema, and skin itching.

[0026] Cicada molt: The molt of the black cicada, an insect of the Cicadidae family, when it is emerging from its pupae. It has anticonvulsant, sedative, reduces skeletal muscle tension, blocks ganglia, relieves bronchial smooth muscle spasms, and has anti-allergic effects. DETAILED DESCRIPTION

[0027] The present invention will be further described below in conjunction with specific embodiments, and the advantages and features of the present invention will become clearer as the description proceeds. However, these embodiments are exemplary only and do not constitute any limitation to the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

[0028] The clinic where the inventor works is known for treating various herpes-related diseases. In practice, the inventor found that a traditional Chinese medicine composition containing Lianzhao, Kochia scoparia, Lonicera japonica, Cuscuta australis, and Periostracum cicadae has a special effect in treating genital herpes. In order to further optimize the best formula, the inventor designed the following implementation formula to compare the therapeutic effects.

[0029] Example 1

[0030] This example provides a Chinese medicine composition for treating genital herpes, which also includes raw materials: 30g of Lianzhao, 30g of Kochia scoparia, 30g of honeysuckle, 40g of Cuscuta, 20g of cicada shell

[0031] The above amount of Chinese medicine composition is prepared into a liquid medicine according to the following steps:

[0032] (1) Place the radix schizonepetae, fructus kochiae, flos lonicerae, fructus doddere (fried), and scutellaria baicalensis into a clean aluminum or iron pot, add 1500 ml of water (pure water) and soak for 30-60 minutes;

[0033] (2) After soaking, use natural gas or liquefied gas to boil over high heat, then simmer over low heat for 30 minutes and then turn off the heat;

[0034] (3) Filter out the drug residue with a filter basket or sterile gauze, and place the drug solution in a sterile container after it cools down;

[0035] (4) Filter the Chinese medicine liquid that has been filtered last time again with sterile sandpaper. After cooling, put it into a clean glass bottle or plastic bottle, seal it, and store it in the refrigerator at 0-3 degrees for future use.

[0036] Example 2

[0037] The present invention provides a traditional Chinese medicine composition for treating genital herpes, comprising 30g of Lianzhao, 30g of Kochia scoparia, 20g of Honeysuckle, 50g of Cuscuta australis, and 20g of Periostracum cicadae.

[0038] The preparation steps are the same as those in Example 1.

[0039] Example 3

[0040] The present embodiment provides a traditional Chinese medicine composition for treating genital herpes, which comprises 30g of Lianzhao, 40g of Kochia scoparia, 30g of Honeysuckle, 20g of Cuscuta australis, and 30g of Periostracum cicadae.

[0041] The steps of making the medicine are the same as those in Example 1.

[0042] Example 4

[0043] The present embodiment provides a traditional Chinese medicine composition for treating genital herpes, the composition comprising: 20g of Lianzhao, 10g of Kochia scoparia, 20g of Honeysuckle, 80g of Cuscuta, and 15g of Periostracum cicadae.

[0044] The steps for preparing the medicine are the same as those in Example 1.

[0045] Comparative Example (1) (without Cuscuta australis)

[0046] Weigh 40g of Lianzhao, 50g of Kochia scoparia, 30g of Honeysuckle, and 30g of Periostracum cicadae to make a medicament, and the steps are the same as those in implementation side 1.

[0047] Comparative Example (2) (excluding continuous calls)

[0048] Weigh 50 g of Kochia scoparia, 10 g of Honeysuckle, 60 g of Cuscuta australis, and 20 g of Periostracum cicadae to prepare a medicine, and the steps are the same as those in Example 1.

[0049] Comparative Example (3) (excluding Kochia scoparia)

[0050] Weigh 20 g of Lian Zhao, 30 g of Honeysuckle, 80 g of Cuscuta australis, and 20 g of Periostracum Cicadae to prepare a medicine, and the steps are the same as those in Example 1.

[0051] Treatment effect analysis:

[0052] In the process of exploring the experimental effects of different formulas, the inventor used different comparative examples and the drug formulas in the embodiments to treat patients. The therapeutic effect of the Chinese medicine composition of the present invention was analyzed by treating more than 100 patients with genital herpes in this clinic. The changes in the conditions of the patients in each group after 10 days of treatment with different embodiment formulas were compared. The results after statistical analysis are shown in Table 1 below, where cure refers to complete relief of scab formation, shedding, and itching and pain.

[0053] Marked effect: The herpes is shriveled, more than 30% of the scabs are formed, and the pain is significantly relieved.

[0054] Ineffective: refers to the herpes shriveling and scab formation being less than 30%, and the pain is not relieved.

[0055] Table 1

[0056]

[0057] The inventors have found in practice that after genital herpes is cured, some patients show discomfort symptoms such as post-herpetic neuralgia due to skin damage. After statistical analysis, the statistical analysis of the treatment results of post-herpetic neuralgia for patients with genital herpes after treatment with the above-mentioned scheme of the present invention is shown in Table 2, where cure means that there is no post-herpetic neuralgia symptom at the site of genital herpes onset.

[0058] Table 2

[0059]

[0060]

[0061] From the above experimental results, it can be seen that the preparation method of the Chinese medicine composition of the present invention is simple. By preparing the external medicine and spraying it on the affected area, it has a high cure rate and a quick effect on genital herpes. Among them, the formula of Example 4 (Formula B) has the best effect, and the effective rate of treating genital herpes is 93%. It can also effectively control the recurrence of genital herpes.

[0062] Typical case treatment process:

[0063] The inventor used the Chinese medicine composition of Example 4 (Formula B) of the present invention to clinically treat and observe dozens of patients with genital herpes from 2019 to 2024, and obtained satisfactory treatment effects for the patients. The case treatment process is as follows.

[0064] Case 1.

[0065] Mr. Yang, male, 33 years old, from Zhoukou City, came to our clinic in July 2019 for genital herpes.

[0066] According to the patient, he had had herpes on his genitals for 4 days. At the beginning, he felt a little burning pain, sometimes like a needle-like pain. He then went to another dermatology department for treatment. At that time, they could not find out what caused the pain, and no herpes or red particles were found in the genitals, so they prescribed oral medication for infection. After taking the medicine for about 3 days, the pain did not improve, and small blisters, small bumps, and granules grew on the genitals. The patient did not know what the disease was and was very worried, so he came to our clinic for treatment. After questioning and careful examination, he was diagnosed with genital herpes. The cause of the disease is complicated, as described above, so the patient began to be treated. Treatment process of genital herpes:

[0067] First, clean and disinfect the patient's genital herpes area;

[0068] Second, the blisters in the affected area are punctured with a sterile needle to allow the water in the herpes to flow out, and then disinfected again. After the local area is dried, the Chinese medicine preparation of Example 1 of the present invention (i.e., Formula A) can be applied or sprayed. After the medication is completed, there is no need to bandage the genitals. The Chinese medicine preparation can be sprayed multiple times a day.

[0069] Fourth, the patient came to our clinic for a follow-up visit the next day. The results of the examination showed that his symptoms had not improved, but were more severe than the day before. The patient kept saying that he had a burning pain, was in great pain, had a very poor mental state, and had a small amount of exudate from the herpes in the genital area. The inventor adjusted the dosage of the Chinese medicine in Formula A, increasing the main medicine (i.e., monarch medicine) Cuscuta chinensis from the original 40g to 80g, Lian Zhao (i.e., minister medicine) from the original 30g to 20g, Kochia scoparia (adjuvant medicine) from the original 30g to 20g, and honeysuckle and cicada shells (helper medicines) from the original 20g to 15g. This formula is the formula of Example 4 written above (i.e., Formula B).

[0070] After following the process and carefully decocting, this improved Chinese medicine combination formula preparation was prepared.

[0071] The patient was given a second careful treatment using the adjusted Chinese medicine preparation formula (Formula B). After cleaning and disinfecting the patient's area again, the improved Formula B Chinese medicine liquid was sprayed. There was no need to bandage the patient, and the spraying could be done multiple times a day.

[0072] When the patient came for the third follow-up examination, his mental state had improved significantly, the treatment condition had improved significantly, the pain was relieved, and there was no more exudate. The treatment effect was very satisfactory.

[0073] After one week of continuous use of Formula B Chinese herbal combination spray, the patient has recovered. Follow-up showed that his genital herpes had not recurred and his body was in good condition.

[0074] Case 2

[0075] Mr. Wang, male, Han, 36 years old, came to our clinic in April 2020. The patient had genital herpes for more than a month and had been treated in a dermatology and venereal disease specialist in a large hospital, but his genital herpes still recurred and did not improve, and he was miserable. Then the patient was treated:

[0076] First, clean and disinfect the patient's genital herpes area;

[0077] Second, after strictly disinfecting the skin of the genital herpes area, puncture the blisters on the affected area one by one with a sterile needle to let the water in the herpes flow out, and then disinfect the skin of the genital herpes again;

[0078] Third, after the local area is dried, the Chinese medicine preparation (Formula B) of the present invention is used to rub or spray the affected area, and no bandage is required after completion. It can be sprayed multiple times a day and reviewed once a day.

[0079] After ten days of effective treatment, the patient was cured. After a period of recovery, his body was completely normal and there was no recurrence of genital herpes.

[0080] Case 3

[0081] Mr. Zhang, male, 39 years old, from Han, Zhoukou City.

[0082] He visited our clinic in September 2024 and was diagnosed with genital herpes after careful examination.

[0083] The patient said that he had genital herpes for a week. He had been to other clinics for treatment, had intravenous infusion, and taken medicine for a few days. He also applied antiviral ointment prescribed by other doctors, but the effect was not very good. After careful examination, it was found that the herpes in the patient's genital area had ulcerated, there were red spots on the glans penis, and there was also ulceration in the coronal sulcus, which was constantly oozing yellow liquid. It was very serious, and the patient felt burning pain. The physical condition was very poor, painful, sighing, and very worried, but the patient did not have systemic symptoms (such as fever, headache, muscle aches, and joint pain, etc.).

[0084] According to the treatment process of Case 1, the Chinese medicine composition spray of Formula B was used for treatment. After a week of careful treatment, the patient has recovered and has no symptoms in the genital area. After a period of recovery, the patient has completely recovered and was later informed that there is no recurrence of genital herpes and everything is normal.

[0085] It can be seen that the pharmaceutical preparation of the Chinese medicine composition of the present invention has achieved very good results in clinical practice and has unexpected therapeutic effects in the treatment of genital herpes.

Claims

1. A Chinese medicine composition for treating genital herpes, characterized in that: The Chinese medicine composition comprises, by weight, 10-30 parts of cicada molts, 10-30 parts of honeysuckle, and 20-80 parts of dodder seeds.

2. The Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition further comprises 10-50 parts of Kochia scoparia seeds by weight.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition further comprises 10-40 parts of Lianzhao in parts by weight.

4. The Chinese medicine composition according to claim 3, characterized in that: The Chinese medicine composition, calculated by weight, includes: 20-30 parts of Lian Zhao, 30-40 parts of Kochia scoparia, 20-30 parts of honeysuckle, 50-80 parts of Cuscuta, and 15-20 parts of cicada shells.

5. The Chinese medicine composition according to claim 4, characterized in that: The Chinese medicine composition, calculated by weight, includes 20 parts of Lian Zhao, 10 parts of Kochia scoparia, 20 parts of honeysuckle, 80 parts of Cuscuta australis, and 15 parts of cicada shells.

6. The Chinese medicine composition according to any one of claims 1 to 5, wherein the Chinese medicine composition is an external preparation.

7. The Chinese medicine composition according to claim 6, wherein the external preparation comprises an ointment, a cream or a spray.

8. Use of the Chinese medicine composition according to any one of claims 1 to 7 in the preparation of a drug for treating genital herpes or post-herpetic neuralgia.

9. A method for preparing a Chinese medicine composition for treating genital herpes, characterized in that: The preparation method comprises the following steps: 1) Mixing and soaking the Chinese medicine composition according to any one of claims 1 to 5 according to the proportion; 2) The soaked composition is decocted with water to prepare a decoction for external spraying or application.

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