Tibetan medicine medicated bath decoction for rheumatoid arthritis and preparation method thereof
By developing a Tibetan medicine medicine bath decoction containing safflower, Duyiwei, Fresh Azalea, Juniper, Artemisia delta and Scythepod and Knot Beans, the medicine bath therapy directly acts on the skin, rheumatoid arthritis is solved by using the medicine bath therapy to directly act on the skin, and the The side effects of drugs in the treatment and the poor efficacy have achieved significant relief of symptoms and improved quality of life.
Patent Information
- Application Number
- CN202411343749.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-25
- Publication Date
- 2024-12-27
AI Technical Summary
The existing treatment methods for rheumatoid arthritis have problems with obvious side effects and poor efficacy of drugs, especially the osteoporosis, liver and kidney function damage caused by the long-term use of traditional drugs, as well as the high cost of biological agents and the treatment of some patients. Adverse reactions.
A Tibetan medicine medicinal bath decoction was developed, including safflower, Duyiwei, Fresh Azalea, Juniper, Artemisia delta and Scythe pods beans. It was prepared through scientific and reasonable formulating and technology, using medicinal bath therapy, and directly It acts on the skin, regulates the immune system, reduces the production of inflammatory factors, and inhibits bone destruction.
The Tibetan medicine medicine bath decoction significantly relieves the symptoms of rheumatoid arthritis, improves the quality of life, avoids the gastrointestinal side effects of traditional drugs, has higher efficacy and safety, reduces the economic burden of patients, and provides a kind of A safer and more effective treatment option.
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Abstract
Description
Technical Field
[0001] The invention relates to the field of Tibetan medicine, and in particular to a Tibetan medicine bath decoction for rheumatoid arthritis and a preparation method thereof. Background Art
[0002] Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by multiple, symmetrical joint inflammation, which is common in small joints such as the hands, feet, wrists, and ankles, and can also affect large joints, causing joint swelling, pain, stiffness, deformity, and even loss of function, seriously affecting the patient's quality of life. Currently, the treatment strategies for RA mainly include drug therapy, physical therapy, surgical treatment, and biological agent therapy.
[0003] At present, the treatment strategies for rheumatoid arthritis mainly include drug therapy, physical therapy, surgical treatment and biological agent treatment. In terms of drug treatment, although traditional glucocorticoids and non-steroidal anti-inflammatory drugs can temporarily relieve arthritis symptoms, long-term use has obvious side effects, such as osteoporosis, liver and kidney damage, etc., and some patients have poor efficacy and are prone to recurrence. Biological agents, as an emerging treatment method, have significant efficacy, but are expensive, and some patients do not respond well to them or develop drug resistance.
[0004] Tibetan medicine bath therapy in Tibetan medicine can directly act on the lesion site through skin penetration, but the existing medicinal bath decoctions are still insufficient in the specific treatment of rheumatoid arthritis and are difficult to meet clinical needs. Summary of the invention
[0005] In view of the above-mentioned deficiencies in the prior art, the present invention provides a Tibetan medicine bath decoction for rheumatoid arthritis and a preparation method thereof. The Tibetan medicine bath decoction has significant efficacy, is safe to use, and is easy to operate, and effectively solves the problems of obvious side effects and poor efficacy of traditional drugs.
[0006] To achieve the above-mentioned purpose, the technical solution adopted by the present invention to solve the technical problem is: to provide a Tibetan medicine bath decoction for rheumatoid arthritis, comprising safflower, safflower, rhododendron, juniper, Artemisia annua and Oxytropis serrata, and the mass ratio of safflower, safflower, rhododendron, juniper, Artemisia annua and Oxytropis serrata is 450-550:450-550:450-550:450-550:450-550:450-550:450-550.
[0007] Furthermore, the Tibetan medicine bath decoction for rheumatoid arthritis includes safflower, angelica dahurica, rhododendron odoratum, juniper, Artemisia annua and Oxytropis serrata, and the mass ratio of safflower, angelica dahurica, rhododendron odoratum, juniper, Artemisia annua and Oxytropis serrata is 500:500:500:500:500:500.
[0008] The preparation method of the Tibetan medicine bath decoction for rheumatoid arthritis comprises the following steps: S1. Make safflower, radix scutellariae, rhododendron australis, juniper, Artemisia grandis and Oxytropis fasciata into coarse powder, add into purified water for decoction, then add distiller's yeast and liquor for fermentation to obtain fermented medicinal materials; S2, adding purified water to the fermented medicinal material obtained in step S1 for decoction, filtering to obtain medicinal solution 2, then continuing to add purified water to the remaining medicinal residue for decoction, filtering to obtain medicinal solution 3, and then adding purified water to the remaining medicinal residue for decoction, filtering to obtain medicinal solution 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a Tibetan medicine bath decoction for rheumatoid arthritis.
[0009] Furthermore, in step S1, the mass volume ratio of safflower, distiller's yeast, liquor and purified water is 450-550 g:100-140 g:8-12 g:2-4 L.
[0010] Furthermore, in step S1, the mass volume ratio of safflower, koji, liquor and pure water is 500g:120g:10g:3L.
[0011] Further, in step S1, the product is sieved through a 10-20 mesh sieve to form a coarse powder.
[0012] Further, in step S1, the mixture is boiled for 8-12 minutes.
[0013] Further, in step S1, the mixture is boiled for 4 minutes.
[0014] Furthermore, in step S1, the fermentation is carried out in a sealed state in a greenhouse at 29-31° C. for 1-2 days.
[0015] Furthermore, in step S1, the mixture is sealed and fermented in a greenhouse at 30° C. for 1 day.
[0016] Furthermore, in step S2, first add 8-10 L of pure water and boil for 25-35 min, then add 6-8 L of pure water and boil for 20-30 min, and then add 4-6 L of pure water and boil for 15-25 min.
[0017] Furthermore, in step S2, first add 9 L of pure water and boil for 30 min, then add 7 L of pure water and boil for 25 min, and then add 5 L of pure water and boil for 20 min.
[0018] The method for using the Tibetan medicine bath decoction for rheumatoid arthritis comprises the following steps: adding the bath decoction into water to prepare a medicinal solution, and completely immersing the patient's diseased joints in the medicinal solution, during which the joints can be appropriately moved to promote the penetration of the medicinal solution.
[0019] Further, add into water at 40-45°C.
[0020] Further, soak in the liquid medicine for 30-60 minutes.
[0021] Furthermore, when performing a local bath, add 20 mL of the drug solution to 1000 mL of water at a temperature of 40°C-45°C, and take a bath; 2 times / day, 20 mL / time.
[0022] Furthermore, when taking a full body bath, add 60 mL of the medicinal solution into 2000 mL of water at a temperature of 40-45° C., and take a bath; 2 times / day, 60 mL / time.
[0023] Furthermore, when taking a steam bath, add 20 mL of the drug solution into 500 mL of water at a temperature of 40-45°C, and then put it into a steam container for fumigation; 2 times / day, 20 mL / time.
[0024] The present invention has the following beneficial effects: 1. The present invention is based on traditional Tibetan medicine theory, combined with modern clinical research and practical experience, and selects a variety of Chinese medicinal materials with the effects of dispelling wind and dampness, promoting blood circulation and unblocking collaterals, reducing swelling and relieving pain, and develops a Tibetan medicine preparation for rheumatoid arthritis. The unique formula combination provided by the present invention: Lamiophlomis rotata (Benth.) Kudo, a plant of the Lamiaceae family, is a dried aerial part; it tastes sweet and bitter, and is flat in nature. It has the effects of promoting blood circulation and stopping bleeding, dispelling wind and relieving pain; it is used for traumatic injuries, fractures, and lumbar sprains. Safflower is a dried flower of Carthamus tinctorius L., a plant of the Asteraceae family, which tastes spicy and is warm in nature. It has the effects of promoting blood circulation and unblocking menstruation, dispersing blood stasis and relieving pain, and is used for diseases such as amenorrhea, dysmenorrhea, postpartum blood stasis, abdominal pain, traumatic swelling, pain, ulcers, swelling, toxins, etc. caused by blood stasis. Rhododendron anthopogonoides Maxim, Rhododendron cephalanthum Franch. and Rhododendron primulaeflarum Bur.et Franch. are all plants of the Ericaceae family. They are sweet and astringent, neutral in nature, and have the effects of expectoration, cough relief and asthma relief. Tibetan medicine often uses them to treat indigestion, spleen deficiency and stomach coldness, and Bacon's disease. Juniper is the young branch with leaves of Juniperus formosana Hayata, a plant of the Cupressaceae family. It is pungent in taste and warm in nature. It has the effects of promoting blood circulation, relieving menstruation, dispersing blood stasis and relieving pain. It is used to treat diseases such as nephritis, edema, rheumatic pain, and traumatic bleeding. Artemisia sieversiana is the dried above-ground part of Artemisia sieversiana Ehrhart ex Willd. or Artemisia frigida Willd., a plant of the Asteraceae family. It tastes slightly sweet and bitter, and is cold in nature. It has the effects of clearing away heat and detoxifying, dispersing swelling and stopping bleeding, and benefiting the kidneys. It is widely used to treat diseases such as swelling of the limbs and joints, kidney disease, carbuncle, sarcoma, hemoptysis, and epistaxis. Oxytropis falcata Bung is the dried whole herb of Oxytropis falcata Bung or O.chiliophylla Royle, a plant of the Leguminosae family. It tastes bitter and is cool in nature; it is toxic. It has the effects of clearing away heat and detoxifying, promoting tissue regeneration and healing sores, stopping bleeding and relieving constipation. The Tibetan medicine bath decoction for rheumatoid arthritis provided by the present invention is prepared by a scientific and reasonable formulation and process, wherein the various medicinal materials play a synergistic role, jointly regulate the human immune system, reduce the production of inflammatory factors, thereby delaying the progression of rheumatoid arthritis, inhibiting bone destruction, and achieving the effect of treating both the symptoms and the root causes. The clinical efficacy of the present invention is significant, and the treatment efficiency is higher than that of traditional drugs such as diclofenac sodium enteric-coated tablets, and it can effectively relieve the pain of patients and improve their quality of life.
[0025] 2. The present invention is made by modern technology and adopts medicated bath therapy, which is convenient to use and can also avoid gastrointestinal discomfort and other side effects that may be caused by oral drugs. It also shows good safety and tolerance during the treatment process, which can reduce the patient's dependence on high-cost drugs, thereby reducing the patient's economic burden to a certain extent.
[0026] 3. The medicinal bath decoction provided by the present invention has significant clinical efficacy and unique advantages in treating rheumatoid arthritis, providing patients with a safer, more effective and convenient treatment option. It has important application value and innovative significance in the field of traditional Chinese medicine and rheumatic disease treatment.
[0027] 4. The present invention has the effects of dispelling wind and cold, removing dampness and relieving pain, dredging meridians and activating collaterals, calming the nerves and promoting sleep. It can be used for rheumatoid arthritis, rheumatoid arthritis, gout, ankylosing spondylitis, intervertebral disc herniation, cervical spondylosis, sciatica, scapulohumeral periarthritis, postpartum wind, chronic eczema, psoriasis, insomnia and other diseases. DETAILED DESCRIPTION
[0028] The principles and features of the present invention are described below, and the examples are only used to explain the present invention and are not used to limit the scope of the present invention. If no specific conditions are specified in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments is not specified, they are all conventional products that can be purchased commercially.
[0029] Example 1 A Tibetan medicine bath decoction for rheumatoid arthritis, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade and set them aside. Collect the whole herb of Oxytropis fasciata when it is in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air and set them aside. Cut the Artemisia grandis when it is in full bloom, pick out the dead leaves, dry them in the shade and set them aside. Collect the leaves and young branches of Rhododendron australis, dry them in the shade and set them aside. Collect the roots and root bark or branches of Juniperus chinensis, dry them in the shade and set them aside. The above medicinal materials have undergone strict quality inspection to ensure that they are free of mildew, insect infestation and impurities. The selected medicinal materials are washed to remove sand and impurities, sliced or crushed to facilitate the full release of effective ingredients in the subsequent decoction process, 500g of safflower, 500g of single spice, 500g of rhododendron, 500g of juniper, 500g of Artemisia grandis and 500g of Oxytropis falcatus are made into coarse powder, added into 3L of pure water and boiled for 10min, then 120g of distiller's yeast and 10g of liquor are added and sealed and fermented in a greenhouse at 30°C for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a Tibetan medicine bath decoction for rheumatoid arthritis.
[0030] Example 2 A Tibetan medicine bath decoction for rheumatoid arthritis, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade and set them aside. Collect the whole herb of Oxytropis fasciata when it is in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air and set them aside. Harvest Artemisia grandis when it is in full bloom, pick the dead leaves, dry them in the shade and set them aside. Collect the leaves and young branches of Rhododendron australis, dry them in the shade and set them aside. Collect the roots and root bark or branches of Juniperus chinensis, dry them in the shade and set them aside. The above medicinal materials have undergone strict quality inspection to ensure that they are free of mildew, insect infestation and impurities. The selected medicinal materials are washed to remove sand and impurities, sliced or crushed to facilitate the full release of effective ingredients in the subsequent decoction process, 450g of safflower, 450g of single spice, 450g of rhododendron, 450g of juniper, 450g of Artemisia grandis and 450g of Oxytropis falcatus are made into coarse powder, added into 2L of pure water and boiled for 8min, and then 100g of distiller's yeast and 8g of liquor are added to the mixture and sealed and fermented in a greenhouse at 29°C for 1d to obtain fermented medicinal materials; S2, adding 8L of pure water to the fermented medicinal material obtained in step S1 and boiling for 25min, filtering to obtain liquid medicine 2, then continuing to add 6L of pure water to the remaining medicinal residue and boiling for 20min, filtering to obtain liquid medicine 3, then adding 4L of pure water to the remaining medicinal residue and boiling for 15min, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a Tibetan medicine bath decoction for rheumatoid arthritis.
[0031] Example 3 A Tibetan medicine bath decoction for rheumatoid arthritis, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade and set them aside. Collect the whole herb of Oxytropis fasciata when it is in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air and set them aside. Cut the Artemisia grandis when it is in full bloom, pick out the dead leaves, dry them in the shade and set them aside. Collect the leaves and young branches of Rhododendron australis, dry them in the shade and set them aside. Collect the roots and root bark or branches of Juniperus chinensis, dry them in the shade and set them aside. The above medicinal materials have undergone strict quality inspection to ensure that they are free of mildew, insect infestation and impurities. The selected medicinal materials are washed to remove sand and impurities, sliced or crushed to facilitate the full release of effective ingredients in the subsequent decoction process, 550g of safflower, 550g of single herb, 550g of rhododendron, 550g of juniper, 550g of Artemisia grandis and 550g of Oxytropis falcatus are made into coarse powder, added into 4L of pure water and decocted for 12min, and then 140g of distiller's yeast and 12g of liquor are added to the mixture and sealed and fermented in a greenhouse at 31°C for 2d to obtain fermented medicinal materials; S2, adding 10L of pure water to the fermented medicinal material obtained in step S1 and boiling for 35 minutes, filtering to obtain liquid medicine 2, then continuing to add 8L of pure water to the remaining medicinal residue and boiling for 30 minutes, filtering to obtain liquid medicine 3, then adding 6L of pure water to the remaining medicinal residue and boiling for 25 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a Tibetan medicine bath decoction for rheumatoid arthritis.
[0032] Comparative Example 1 A medicinal bath decoction, the preparation method of which comprises the following steps: S1, select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process, collect the whole grass of sickle pod thorn bean in full bloom, remove dead leaves and residual stems, wash the soil, dry and set aside, harvest the large seed wormwood in full bloom, pick the dead leaves, dry in the shade, set aside, collect leaves and twigs of fierce fragrant azalea, dry in the shade, set aside, collect roots and root bark or branches and leaves of juniper, dry in the shade, set aside, the above medicinal materials are strictly inspected for quality to ensure that there is no mildew, insect infestation and impurities, wash the selected medicinal materials, remove sediment and impurities, slice or crush them, so as to fully release the effective ingredients in the subsequent decoction process, make 500g of single herb, 500g of fierce fragrant azalea, 500g of juniper, 500g of large seed wormwood and 500g of sickle pod thorn bean into coarse powder, add 3L of pure water and decoct for 10min, then add 120g of distiller's yeast and 10g of liquor to seal and ferment in a greenhouse at 30°C for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a medicinal bath decoction.
[0033] Comparative Example 2 A medicinal bath decoction, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade and set them aside. Collect the whole herb of Oxytropis fasciata when it is in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air and set them aside. Cut the herb when it is in full bloom, pick the dead leaves, dry them in the shade and set them aside. Collect the leaves and young branches of Rhododendron australis, dry them in the shade and set them aside. Collect the roots and root bark or branches of Juniperus chinensis, dry them in the shade and set them aside. The above medicinal materials have undergone strict quality inspection to ensure that they are free of mildew, insect infestation and impurities, wash the selected medicinal materials, remove the sand and impurities, slice or crush them, so as to fully release the effective ingredients in the subsequent decoction process, make 500g of safflower, 500g of azalea, 500g of juniper, 500g of Artemisia grandis and 500g of Oxytropis falcatus into coarse powder, add 3L of pure water and boil for 10min, then add 120g of distiller's yeast and 10g of liquor and seal and ferment in a greenhouse at 30℃ for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a medicinal bath decoction.
[0034] Comparative Example 3 A medicinal bath decoction, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade for later use, collect the whole grass of sickle-pod thorn bean in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air for later use, harvest the large-seed wormwood in full bloom, pick the dead leaves, dry them in the shade for later use, collect the roots and root bark or branches and leaves of juniper, dry them in the shade for later use, and the above-mentioned medicinal materials undergo strict quality inspection to ensure that they are free of mildew, insect infestation and impurities. Wash the selected medicinal materials, remove the sediment and impurities, and slice or crush them to facilitate the full release of the effective ingredients in the subsequent decoction process. Make 500g of safflower, 500g of single herb, 500g of juniper, 500g of large-seed wormwood and 500g of sickle-pod thorn bean into coarse powder, add 3L of pure water and decoct for 10min, then add 120g of distiller's yeast and 10g of liquor to seal and ferment in a greenhouse at 30°C for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a medicinal bath decoction.
[0035] Comparative Example 4 A medicinal bath decoction, the preparation method of which comprises the following steps: S1, select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process, pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade for later use, collect the whole grass of sickle pod thorn bean in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air for later use, harvest the large seed wormwood in full bloom, pick the dead leaves, dry them in the shade for later use, pick the leaves and young branches of fierce fragrant azalea, dry them in the shade for later use, and the above-mentioned medicinal materials undergo strict quality inspection to ensure that there is no mildew, insect infestation and impurities. The selected medicinal materials are cleaned, the sediment and impurities are removed, and the slices or crushed are processed to facilitate the full release of the effective ingredients in the subsequent decoction process. 500g safflower, 500g single herb, 500g fierce fragrant azalea, 500g large seed wormwood and 500g sickle pod thorn bean are made into coarse powder, added to 3L pure water and decocted for 10min, and then 120g distiller's yeast and 10g liquor are added to the greenhouse at 30°C and sealed and fermented for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a medicinal bath decoction.
[0036] Comparative Example 5 A medicinal bath decoction, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade for later use, collect the whole herb of sickle-pod thorn bean in full bloom, remove the dead leaves and residual stems, wash the soil, dry them in the air for later use, collect leaves and twigs of fierce fragrant azalea, dry them in the shade for later use, collect roots and root bark or branches and leaves of juniper, dry them in the shade for later use, and the above-mentioned medicinal materials undergo strict quality inspection to ensure that they are free of mildew, insect infestation and impurities. Wash the selected medicinal materials, remove the sand and impurities, slice them or crush them, so as to fully release the effective ingredients in the subsequent decoction process, make 500g safflower, 500g single herb, 500g fierce fragrant azalea, 500g juniper and 500g sickle-pod thorn bean into coarse powder, add 3L pure water and decoct for 10min, then add 120g distiller's yeast and 10g liquor to seal and ferment in a greenhouse at 30°C for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a medicinal bath decoction.
[0037] Comparative Example 6 A medicinal bath decoction, the preparation method of which comprises the following steps: S1. Select Chinese medicinal materials that meet the pharmacopoeia standards, harvest and process them. Pick the tubular flowers of safflower when the petals turn from yellow to red in July and August, dry them in the shade for later use, harvest them when the big seed wormwood is in full bloom, pick the dead leaves, dry them in the shade for later use, pick the leaves and twigs of fierce fragrant azalea, dry them in the shade for later use, and pick the roots and root bark or branches of juniper, dry them in the shade for later use. The above medicinal materials undergo strict quality inspection to ensure that they are free of mildew, insect infestation and impurities. Wash the selected medicinal materials, remove the sand and impurities, and slice or crush them to facilitate the full release of the effective ingredients in the subsequent decoction process. Make 500g of safflower, 500g of single herb, 500g of fierce fragrant azalea, 500g of juniper and 500g of big seed wormwood into coarse powder, add 3L of pure water and decoct for 10min, then add 120g of distiller's yeast and 10g of liquor to seal and ferment in a greenhouse at 30°C for 1d to obtain fermented medicinal materials; S2, adding 9L of pure water to the fermented medicinal material obtained in step S1, boiling for 30 minutes, filtering to obtain liquid medicine 2, then continuing to add 7L of pure water to the remaining medicinal residue, boiling for 25 minutes, filtering to obtain liquid medicine 3, and then adding 5L of pure water to the remaining medicinal residue, boiling for 20 minutes, filtering to obtain liquid medicine 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a medicinal bath decoction.
[0038] Test Example 1 The clinical efficacy of the Tibetan medicine bath decoction for rheumatoid arthritis prepared in Examples 1 to 3 and the medicinal bath decoction prepared in Comparative Examples 1 to 6 on rheumatoid arthritis was compared. 90 patients with rheumatoid arthritis were divided into 9 groups, 10 in each group, and then comparative treatment was performed to explore the therapeutic effect of the Tibetan medicine bath decoction for rheumatoid arthritis provided by the present invention.
[0039] The dosage of each medicated bath patient is 15L, and the treatment is carried out in a fumigation manner. By comparing the changes in arthritis-related indicators such as joint edema degree, joint morning stiffness time, joint pain score, joint swelling score, rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate before and after treatment, as well as the occurrence of adverse reactions, the efficacy and safety of the present invention are comprehensively evaluated. The experimental results are obtained by visual analog scale (VAS) and serological tests. Among them, the comparison results of joint edema degree are shown in Table 1, the comparison results of joint morning stiffness time are shown in Table 2, the comparison results of joint pain score are shown in Table 3, the comparison results of joint swelling score are shown in Table 4, the change results of rheumatoid factor are shown in Table 5, the change results of C-reactive protein are shown in Table 6, and the change results of erythrocyte sedimentation rate are shown in Table 7.
[0040] Note: During use, pay attention to observe the patient's reaction. If allergic reaction or discomfort occurs, stop using it immediately and seek medical attention. At the same time, avoid splashing the liquid into sensitive parts such as eyes or mouth.
[0041] Table 1 Comparison of joint edema before and after treatment
[0042] Table 2 Comparison of joint morning stiffness time before and after treatment
[0043] Table 3 Comparison of joint pain scores before and after treatment
[0044] Table 4 Comparison of joint swelling scores before and after treatment
[0045] Table 5 Changes of rheumatoid factor before and after treatment
[0046] Table 6 Changes of C-reactive protein before and after treatment
[0047] Table 7 Changes in ESR before and after treatment
[0048] As shown in Tables 1 to 7, the Tibetan medicine bath decoction provided by the present invention shows significant efficacy in the treatment of rheumatoid arthritis. The improvement of the patient's symptoms after treatment is significantly better than before treatment, and no serious adverse reactions occur. This shows that the use of Tibetan medicine bath decoction is a safe and effective new method for treating rheumatoid arthritis, which can significantly alleviate the patient's symptoms, improve joint function, and has high safety and no obvious side effects. Its unique formulation and preparation process enable the drug ingredients to better penetrate the skin and reach the lesions directly, thereby exerting a therapeutic effect. In addition, the invention also provides a convenient way of use, which helps to improve the patient's treatment compliance and satisfaction.
[0049] The evaluation of treatment effect showed that the patients had significant improvement after treatment. Specifically, the degree of joint swelling was reduced, the duration of morning joint stiffness was shortened, the score of the Rheumatoid Arthritis Clinical Outcome Scale was reduced, and the level of rheumatoid factor was significantly reduced compared with before treatment. These changes reached statistical significance ( P <0.01). In addition, the comparison of C-reactive protein and erythrocyte sedimentation rate before and after treatment also showed a statistically significant decrease ( P <0.05).
[0050] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims
1. A Tibetan medicine bath decoction for rheumatoid arthritis, characterized in that: The invention comprises safflower, angelica dahurica, rhododendron amurense, juniper, wormwood and oxytropis serrata, and the mass ratio of safflower, angelica dahurica, rhododendron amurense, juniper, wormwood and oxytropis serrata is 450-550:450-550:450-550:450-550:450-550:450-550:450-550.
2. The Tibetan medicine bath decoction for rheumatoid arthritis according to claim 1, characterized in that: The invention comprises safflower, angelica dahurica, rhododendron amurense, juniper, wormwood and oxytropis serrata, and the mass ratio of safflower, angelica dahurica, rhododendron amurense, juniper, wormwood and oxytropis serrata is 500:500:500:500:500:500:
500.
3. The method for preparing the Tibetan medicine bath decoction for rheumatoid arthritis according to claim 1 or 2, characterized in that: The following steps are involved: S1. Make safflower, radix scutellariae, rhododendron australis, juniper, Artemisia grandis and Oxytropis fasciata into coarse powder, add into purified water for decoction, then add distiller's yeast and liquor for fermentation to obtain fermented medicinal materials; S2, adding purified water to the fermented medicinal material obtained in step S1 for decoction, filtering to obtain medicinal solution 2, then continuing to add purified water to the remaining medicinal residue for decoction, filtering to obtain medicinal solution 3, and then adding purified water to the remaining medicinal residue for decoction, filtering to obtain medicinal solution 4; S3, mixing the medicinal solution 2, the medicinal solution 3 and the medicinal solution 4 obtained in step S2 evenly to obtain a Tibetan medicine bath decoction for rheumatoid arthritis.
4. The method for preparing the Tibetan medicine bath decoction for rheumatoid arthritis according to claim 3, characterized in that: In step S1, the mass volume ratio of safflower, white wine and purified water is 450-550g:100-140g:8-12g:2-4L.
5. The method for preparing the Tibetan medicine bath decoction for rheumatoid arthritis according to claim 3, characterized in that: In step S1, the mixture is decocted for 8-12 minutes.
6. The method for preparing the Tibetan medicine bath decoction for rheumatoid arthritis according to claim 3, characterized in that: In step S1, the mixture is sealed and fermented in a greenhouse at 29-31° C. for 1-2 days.
7. The method for preparing the Tibetan medicine bath decoction for rheumatoid arthritis according to claim 3, characterized in that: In step S2, first add 8-10 L of purified water and boil for 25-35 min, then add 6-8 L of purified water and boil for 20-30 min, and then add 4-6 L of purified water and boil for 15-25 min.