Peritoneal dialysis device

Abstract

The invention discloses a peritoneal dialysis device. The peritoneal dialysis device comprises a peritoneal dialysis assembly and a peritoneal dialysis tube detachably connected with the peritoneal dialysis assembly. The peritoneal dialysis assembly comprises a dialysate bag, a drainage bag and a three-way connector, a liquid inlet connector is arranged on the dialysate bag, the dialysate bag is connected with the three-way connector through an infusion tube, the drainage bag is connected with the three-way connector through a drainage tube, the three-way connector is further connected with a connecting tube, and the connecting tube is connected with the drainage bag. A connecting joint is arranged at one end, far away from the three-way joint, of the connecting pipe, and a protective cap sleeves the connecting joint. The peritoneal dialysis protective cap solves the problems that an existing protective cap is prone to falling off and a peritoneal dialysis catheter is prone to being blocked.

Description

Technical Field

[0001] The present invention relates to the technical field of dialysis, in particular to a peritoneal dialysis device. Background Art

[0002] The peritoneal dialysis fluid bag is a combination of medicine and medical equipment. When the product is used, the connector protective cap needs to be removed first to connect the connecting joint to the peritoneal dialysis tube in the patient's abdomen. Therefore, the sealing of the protective cap and the connecting joint is particularly important during the product validity period. However, the existing connector protective cap for storing peritoneal dialysis fluid is easy to fall off, and the protective cap of the interface often falls off when the medicine has not been used, thereby making the product unusable. At the same time, when connecting to the patient's abdominal affected area, it is also impossible to effectively ensure that the whole is not infected due to the falling of the protective cap, which has a certain risk factor.

[0003] In addition, existing peritoneal dialysis tubes are mainly made of silicone rubber material, but silicone rubber material is easy to absorb proteins and bacteria in the peritoneal fluid during peritoneal dialysis, thereby causing blockage of the dialysis holes and the tube. Summary of the invention

[0004] Based on the technical problems existing in the background technology, the present invention proposes a peritoneal dialysis device, which solves the problems that the protective cap is easy to fall off and the peritoneal dialysis tube is easy to be blocked.

[0005] The peritoneal dialysis device proposed in the present invention comprises a peritoneal dialysis component and a peritoneal dialysis tube detachably connected to the peritoneal dialysis component; the peritoneal dialysis component comprises a dialysate bag, a drainage bag and a three-way joint, the dialysate bag is provided with a liquid inlet joint, the dialysate bag is connected to the three-way joint through an infusion tube, the drainage bag is connected to the three-way joint through a drainage tube, the three-way joint is also connected to a connecting tube, a connecting joint is provided at one end of the connecting tube away from the three-way joint, and a protective cap is sleeved on the connecting joint.

[0006] Preferably, the protective cap includes a shell, a slot is provided inside the bottom end of the shell, a top block is formed by providing an installation slot inside the top end of the shell, and pull blocks arranged in a triangular shape are fixedly connected to the outer walls of both sides of the shell near the lower end, and a pull ring is fixedly connected to the side of the pull block away from the shell, one end of the connecting joint is inserted into the slot, and the top block is inserted into the interior of the connecting joint.

[0007] Preferably, the outer walls on both sides of the shell near the bottom end are fixedly connected with symmetrically arranged support rods, the side of the support rod away from the shell is fixedly connected with a vertical plate, the opposite side of the vertical plate near the lower end is fixedly connected with an elastic telescopic rod, the output end of the elastic telescopic rod is fixedly connected with a clamping plate, the clamping plate and the vertical plate are commonly fixedly connected with a spring, and the spring is movably sleeved on the outside of the elastic telescopic rod.

[0008] Preferably, a soft cushion is fixedly connected to one side of the clamping plate away from the elastic telescopic rod; and the clamping plate as a whole is arranged in an arc shape at the bottom end of the housing.

[0009] Preferably, a sealing ring is fixedly connected to the inner side wall of the slot opening.

[0010] Preferably, the peritoneal dialysis tube comprises a tube body, one end of which is provided with a plurality of dialysis holes, one end of which is away from the dialysis holes and is detachably connected to the connecting joint, and the tube body is further provided with a first ring and a second ring distributed at intervals.

[0011] Preferably, the tube body is made of a cross-linked ethylene-octene copolymer doped with barium sulfate powder, and a tube wall of the tube body is provided with a protective layer.

[0012] Preferably, the method steps for providing a protective layer on the tube wall of the tube body are as follows:

[0013] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification;

[0014] S2: Immerse the tube body modified by amino in S1 into the first protective solution, take it out and dry it, and then immerse it into the second protective solution. Repeat the immersion in the first protective solution and the second protective solution 3-6 times to form a protective layer on the tube wall of the tube body.

[0015] Preferably, S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 30-60%; the mass concentration of the polyethyleneimine solution is 0.04-0.08%.

[0016] Preferably, the first protective solution in S2 is a polysaccharide solution with a mass concentration of 10-30 g / L, the polysaccharide is composed of polygonatum polysaccharide, red algae polysaccharide and black fungus polysaccharide in a mass ratio of 2:1-4:1-4, the temperature of each immersion in the first protective solution is 30-50°C, and the time is 10-30 min; the second protective solution is composed of methacryloyloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 3:1-9, the temperature of each immersion in the second protective solution is 40-60°C, and the time is 10-20 min.

[0017] Beneficial technical effects of the present invention:

[0018] (1) The present invention changes the top of the cap body from a flat surface to a groove, so that the inside of the cap body fits tightly with the circular surface of the top of the joint. The circular edge of the cap body fits more closely with the outer surface of the joint, which becomes a resistance to the opening of the protective cap. The circular surface is changed into a hollow arc symmetrical on both sides, so that the opening force point of the pull ring is concentrated, which is convenient for opening. The two wings of the cap body are injection-molded into a triangle and connected to the pull ring, which buffers the force of the pull ring and is not easy to break. At the same time, the telescopic rod and the spring are used to facilitate the splint to connect the lower end pipe in the afternoon, further increasing the overall connection stability and preventing it from falling off.

[0019] (2) The present invention can effectively avoid the precipitation of barium sulfate powder and cross-linking agent by forming a protective layer on the peritoneal dialysis tube, thereby reducing the risk of peritonitis in dialysis patients. The protective layer can also prevent the adhesion of proteins and bacteria in the peritoneal fluid to the tube wall and cause blockage of the dialysis holes and the tube body; the polysaccharide in the first protective liquid can form a chemical bond with the amino-modified tube wall, and is immersed in the second protective liquid through layer-by-layer self-assembly. Under the action of the tube body's own cross-linking agent, a cross-linked network structure can be formed, which not only improves the smoothness of the tube wall surface, but also has an excellent anti-coagulation effect, and can also avoid the precipitation of barium sulfate powder and cross-linking agent in the tube body. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the structure of the peritoneal dialysis assembly proposed by the present invention;

[0021] Figure 2 A schematic diagram of the structure of the protective cap proposed by the present invention;

[0022] Figure 3 A side view of the protective cap proposed by the present invention;

[0023] Figure 4 A top view of the protective cap provided by the present invention;

[0024] Figure 5 A side cross-sectional view of the protective cap provided by the present invention;

[0025] Figure 6 A bottom view of the protective cap provided by the present invention;

[0026] Figure 7 This is a schematic diagram of the structure of the peritoneal dialysis tube proposed by the present invention.

[0027] In the figure: 1-dialysis fluid bag, 2-liquid inlet connector, 3-infusion tube, 4-drainage bag, 5-drainage tube, 6-tee connector, 7-connecting connector, 8-protective cap, 81-housing, 82-card slot, 83-top block, 84-pull block, 85-pull ring, 86-support rod, 87-vertical plate, 88-elastic telescopic rod, 89-splint, 810-spring, 811-sealing ring, 812-cushion, 9-connecting tube, 10-tube body, 11-first ring, 12-second ring, 13-dialysis hole. DETAILED DESCRIPTION

[0028] The present invention will be further explained below in conjunction with specific embodiments.

[0029] Example 1

[0030] Reference Figure 1-6 The peritoneal dialysis device proposed in the present invention comprises a peritoneal dialysis component and a peritoneal dialysis tube detachably connected to the peritoneal dialysis component; the peritoneal dialysis component comprises a dialysate bag 1, a drainage bag 4 and a three-way joint 6, the dialysate bag 1 is provided with a liquid inlet joint 2, the dialysate bag 1 is connected to the three-way joint 6 through an infusion tube 3, the drainage bag 4 is connected to the three-way joint 6 through a drainage tube 5, the three-way joint 6 is also connected to a connecting tube 9, a connecting joint 7 is provided at one end of the connecting tube 9 away from the three-way joint 6, and a protective cap 8 is sleeved on the connecting joint 7.

[0031] The protective cap 8 includes a sleeve shell 81, a card slot 82 is opened inside the bottom end of the sleeve shell 81, and a top block 83 is formed by opening a mounting groove inside the top end of the sleeve shell 81. The outer walls on both sides of the sleeve shell 81 near the lower end are fixedly connected with a pull block 84 arranged in a triangular shape, and the side of the pull block 84 away from the sleeve shell 81 is fixedly connected with a pull ring 85. One end of the connecting joint 7 is inserted into the card slot 82, and the top block 83 is inserted into the inside of the connecting joint 7.

[0032] The outer walls on both sides of the casing 81 near the bottom end are fixedly connected with symmetrically arranged support rods 86, the side of the support rods 86 away from the casing 81 is fixedly connected with a vertical plate 87, the opposite side of the vertical plate 87 near the lower end is fixedly connected with an elastic telescopic rod 88, the output end of the elastic telescopic rod 88 is fixedly connected with a clamping plate 89, the clamping plate 89 and the vertical plate 87 are jointly fixedly connected with a spring 810, and the spring 810 is movably sleeved on the outside of the elastic telescopic rod 88.

[0033] A soft cushion 812 is fixedly connected to one side of the clamping plate 89 away from the elastic telescopic rod 88 ; the clamping plate 89 as a whole is in an arc shape and is arranged at the bottom end of the sleeve 81 .

[0034] A sealing ring 811 is fixedly connected to the inner wall of the slot 82 .

[0035] Reference Figure 7The peritoneal dialysis tube includes a tube body 10, one end of which is provided with a plurality of dialysis holes 13, and one end of the tube body 10 away from the dialysis holes 13 is detachably connected to the connecting joint 7, and the tube body 10 is also provided with a first ring 11 and a second ring 12 distributed at intervals.

[0036] The present invention stably sleeves on the connecting joint through the card slot 82 inside the sleeve 81, and at the same time cooperates with the top block 83 formed inside the top of the sleeve 81 with the installation slot to make the inside of the cap body fit tightly with the circular surface of the top of the joint, and cooperates with the overall annular edge of the cap body of the sleeve 81 to fit the outer surface of the joint more closely, becoming a resistance to opening the protective cap, and the annular surface is changed into a hollow arc symmetrical on both sides, so that the opening force point of the pull ring is concentrated, which is easy to open, and cooperates with the pull blocks 84 and the pull ring 85 arranged in a triangular shape on both sides of the sleeve 81 to greatly increase the connection stability, buffer the pull ring force, and is not easy to At the same time, when the sleeve 81 is stably connected, the clamping plate 89 is pulled to both sides, and the clamping plate 89 is forced to move to compress the spring 810 and the elastic telescopic rod 88. At this time, the elastic action of the spring 810 and the elastic telescopic rod 88 will stably drive the clamping plate 89 to stably clamp on the connecting joint for further limiting, thereby further increasing the connection stability between the sleeve 81 and the connecting joint 7. When in use, the sleeve 81 is pulled apart by the pull ring 85 and the pull block 84, and then the connecting joint 7 is connected to the tube body 10 of the peritoneal dialysis tube inserted into the patient's abdominal cavity.

[0037] In order to solve the problem of precipitation of barium sulfate powder and cross-linking agent in the tube body, thereby reducing the risk of peritonitis in dialysis patients, and the protective layer can also prevent the adhesion of proteins and bacteria in the peritoneal fluid to the tube wall and cause blockage of the dialysis holes and the tube body, the tube body 10 is made of a cross-linked ethylene-octene copolymer doped with barium sulfate powder, and the tube wall of the tube body 10 is provided with a protective layer. The method steps for providing the protective layer on the tube wall of the tube body are as follows:

[0038] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification;

[0039] S2: Immerse the tube body modified by amino in S1 in the first protective solution, take it out and dry it, then immerse it in the second protective solution. Repeat the immersion in the first protective solution and the second protective solution 4 times to form a protective layer on the tube wall of the tube body.

[0040] S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 45%; the mass concentration of the polyethyleneimine solution is 0.06%.

[0041] The first protective solution in S2 is a polysaccharide solution with a mass concentration of 20 g / L. The polysaccharides are composed of Polygonatum sibiricum polysaccharide, red algae polysaccharide and Auricularia auricula polysaccharide in a mass ratio of 1:1:1. The temperature of each immersion in the first protective solution is 40°C and the time is 20 min. The second protective solution is composed of methacryloyloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 1:1. The temperature of each immersion in the second protective solution is 50°C and the time is 15 min.

[0042] Example 2

[0043] The method for providing a protective layer on the tube wall of the peritoneal dialysis tube proposed by the present invention comprises the following steps:

[0044] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification;

[0045] S2: Immerse the tube body modified by amino in S1 in the first protective solution, take it out and dry it, and then immerse it in the second protective solution. Repeat the immersion in the first protective solution and the second protective solution for 3 times to form a protective layer on the tube wall of the tube body.

[0046] S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 30%; the mass concentration of the polyethyleneimine solution is 0.04%.

[0047] The first protective solution in S2 is a polysaccharide solution with a mass concentration of 10 g / L. The polysaccharides are composed of Polygonatum sibiricum polysaccharide, red algae polysaccharide and Auricularia auricula polysaccharide in a mass ratio of 2:1:1. The temperature of each immersion in the first protective solution is 30°C and the time is 10 min. The second protective solution is composed of methacryloyloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 3:1. The temperature of each immersion in the second protective solution is 40°C and the time is 10 min.

[0048] The remaining conditions are the same as those in Example 1.

[0049] Example 3

[0050] The method for providing a protective layer on the tube wall of the peritoneal dialysis tube proposed by the present invention comprises the following steps:

[0051] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification;

[0052] S2: Immerse the tube body modified by amino in S1 in the first protective solution, take it out and dry it, and then immerse it in the second protective solution. Repeat the immersion in the first protective solution and the second protective solution for 6 times to form a protective layer on the tube wall of the tube body.

[0053] S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 60%; the mass concentration of the polyethyleneimine solution is 0.08%.

[0054] The first protective solution in S2 is a polysaccharide solution with a mass concentration of 30 g / L. The polysaccharides are composed of Polygonatum sibiricum polysaccharide, red algae polysaccharide and Auricularia auricula-judae polysaccharide in a mass ratio of 1:2:2. The temperature of each immersion in the first protective solution is 50°C and the time is 30 min. The second protective solution is composed of methacryloyloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 1:3. The temperature of each immersion in the second protective solution is 60°C and the time is 20 min.

[0055] The remaining conditions are the same as those in Example 1.

[0056] Comparative Example 1

[0057] The polysaccharide of this scheme is composed of polygonatum polysaccharide and red algae polysaccharide in a mass ratio of 1:1, and the other conditions are the same as those in Example 1.

[0058] Comparative Example 2

[0059] The polysaccharide of this scheme is composed of polygonatum polysaccharide and black fungus polysaccharide in a mass ratio of 1:1, and the other conditions are the same as those in Example 1.

[0060] Comparative Example 3

[0061] The polysaccharide of this scheme is composed of red algae polysaccharide and black fungus polysaccharide in a mass ratio of 1:1, and the other conditions are the same as those in Example 1.

[0062] Comparative Example 4

[0063] The method and steps for providing a protective layer on the tube wall of the peritoneal dialysis tube of this scheme are as follows:

[0064] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification;

[0065] S2: Immerse the tube body modified by amino in S1 into the first protective solution, take it out and dry it, and then immerse it into the first protective solution again for 4 times.

[0066] S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 45%; the mass concentration of the polyethyleneimine solution is 0.06%.

[0067] The first protective solution in S2 is a polysaccharide solution with a mass concentration of 20 g / L. The polysaccharide is composed of polygonatum polysaccharide, red algae polysaccharide and black fungus polysaccharide in a mass ratio of 1:1:1. The temperature of each immersion in the first protective solution is 40°C and the time is 20 min.

[0068] Comparative Example 5

[0069] The method and steps for providing a protective layer on the tube wall of the peritoneal dialysis tube of this scheme are as follows:

[0070] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification;

[0071] S2: Immerse the tube body modified by amino in S1 into the second protective solution, take it out and dry it, and then immerse it into the second protective solution again for 4 times.

[0072] S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 45%; the mass concentration of the polyethyleneimine solution is 0.06%.

[0073] The second protective liquid in S1 is composed of methacryloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 1:1. The temperature of each immersion in the second protective liquid is 50° C. and the time is 15 min.

[0074] The anti-coagulation performance of the peritoneal dialysis tubes prepared in Examples 1-3 and Comparative Examples 1-5 was tested. The specific method was as follows: the peritoneal dialysis tube body was cut into a size of 0.5 cm × 0.5 cm and placed in a 24-well culture plate, and then 600 μL of platelet-poor plasma was dripped into each sample well, incubated in a constant temperature water bath at 37°C for 2 hours, and the plasma thromboplastin time, prothrombin time and thrombin time were measured. The results are shown in Table 1.

[0075] Table 1 Anticoagulant performance test results

[0076] Group Thromboplastin time (s) Prothrombin time (s) Thrombin time (s) Example 1 106.5 28.3 74.9 Example 2 90.2 21.4 68.1 Example 3 101.3 26.5 72.8 Comparative Example 1 61.6 18.5 48.0 Comparative Example 2 64.1 19.2 45.9 Comparative Example 3 62.4 18.9 47.3 Comparative Example 4 50.6 15.8 36.1 Comparative Example 5 42.1 13.7 29.5

[0077] It can be seen from the test results of Example 1 and Comparative Examples 1-3 that the present invention has a good anticoagulant effect by forming a protective layer on the peritoneal dialysis tube, and the polysaccharide of the first protective solution of the present invention is composed of Polygonatum sibiricum polysaccharide, red algae polysaccharide and black fungus polysaccharide, which has a synergistic effect in improving the anticoagulant performance of the peritoneal dialysis tube. In addition, the present invention immerses the second protective solution in a layer-by-layer self-assembly manner, and under the action of the tube body's own cross-linking agent, a cross-linked network structure can be formed, which not only improves the smoothness of the tube wall surface, but also can further improve the anticoagulant effect of the tube body.

Claims

1. A peritoneal dialysis device, characterized in that: The invention comprises a peritoneal dialysis component and a peritoneal dialysis tube detachably connected to the peritoneal dialysis component; the peritoneal dialysis component comprises a dialysate bag (1), a drainage bag (4) and a three-way joint (6); the dialysate bag (1) is provided with a liquid inlet joint (2); the dialysate bag (1) is connected to the three-way joint (6) via an infusion tube (3); the drainage bag (4) is connected to the three-way joint (6) via a drainage tube (5); the three-way joint (6) is further connected to a connecting tube (9); a connecting joint (7) is provided at one end of the connecting tube (9) away from the three-way joint (6); a protective cap (8) is sleeved on the connecting joint (7).

2. The peritoneal dialysis device according to claim 1, characterized in that The protective cap (8) comprises a sleeve (81), a slot (82) is provided at the bottom of the sleeve (81), a top block (83) is formed by providing a mounting slot at the top of the sleeve (81), a pull block (84) arranged in a triangular shape is fixedly connected to the outer walls of both sides of the sleeve (81) near the lower end, a pull ring (85) is fixedly connected to the side of the pull block (84) away from the sleeve (81), one end of the connecting joint (7) is inserted into the slot (82), and the top block (83) is inserted into the inside of the connecting joint (7).

3. The peritoneal dialysis device according to claim 2, characterized in that: The outer side walls of the casing (81) on both sides near the bottom end are fixedly connected with symmetrically arranged support rods (86); the side of the support rods (86) away from the casing (81) is fixedly connected with a vertical plate (87); the side of the vertical plate (87) facing the lower end is fixedly connected with an elastic telescopic rod (88); the output end of the elastic telescopic rod (88) is fixedly connected with a clamping plate (89); the clamping plate (89) and the vertical plate (87) are both fixedly connected with a spring (810); and the spring (810) is movably sleeved on the outside of the elastic telescopic rod (88).

4. The peritoneal dialysis device according to claim 3, characterized in that: A soft cushion (812) is fixedly connected to one side of the clamping plate (89) away from the elastic telescopic rod (88); the clamping plate (89) is arranged at the bottom end of the sleeve (81) in an arc shape as a whole.

5. The peritoneal dialysis device according to claim 2, characterized in that: A sealing ring (811) is fixedly connected to the inner side wall of the slot (82).

6. The peritoneal dialysis device according to claim 1, characterized in that: The peritoneal dialysis tube comprises a tube body (10), one end of the tube body (10) is provided with a plurality of dialysis holes (13), the end of the tube body (10) away from the dialysis holes (13) is detachably connected to the connecting joint (7), and the tube body (10) is also provided with a first ring (11) and a second ring (12) which are spaced apart.

7. The peritoneal dialysis device according to claim 6, characterized in that: The tube body (10) is made of a cross-linked ethylene-octene copolymer doped with barium sulfate powder, and the tube wall of the tube body (10) is provided with a protective layer.

8. The peritoneal dialysis device according to claim 7, characterized in that: The method steps for providing a protective layer on the tube wall of the tube body are as follows: S1: Acidify the tube body and then add polyethyleneimine solution for amino modification; S2: Immerse the tube body modified by amino in S1 into the first protective solution, take it out and dry it, and then immerse it into the second protective solution. Repeat the immersion in the first protective solution and the second protective solution 3-6 times to form a protective layer on the tube wall of the tube body.

9. The peritoneal dialysis device according to claim 8, characterized in that: S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 30-60%; the mass concentration of the polyethyleneimine solution is 0.04-0.08%.

10. The peritoneal dialysis device according to claim 8, characterized in that: The first protective solution in S2 is a polysaccharide solution with a mass concentration of 10-30 g / L, and the polysaccharides are composed of polygonatum polysaccharide, red algae polysaccharide and black fungus polysaccharide in a mass ratio of 2:1-4:1-4. The temperature of each immersion in the first protective solution is 30-50°C and the time is 10-30 min. The second protective solution is composed of methacryloyloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 3:1-9. The temperature of each immersion in the second protective solution is 40-60°C and the time is 10-20 min.

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