Impurity removal device for producing and processing crude heparin sodium

Abstract

The invention relates to the technical field of heparin sodium processing, and discloses an impurity removal device for heparin sodium crude product production and processing, which comprises a mounting table, an auger blade is rotatably mounted on the mounting table, the auger blade is driven by a driving source to rotate, and the edge of the auger blade is in sliding fit with the inner wall of a conveying cylinder fixed on the mounting table; viewed from the section, the gap between the outer ring and the inner ring is in the shape of an inverted right trapezoid, which means that small intestines are gradually twisted into fine fragments in the falling process, and larger small intestine fragments contained in a solution can be found in time by detecting an extraction solution subjected to impurity removal treatment, so that the inner ring is adjusted to descend, and the small intestines are prevented from falling off. The small intestine fragments which are not minced last time can be minced through the outer circular ring, the problem that excessive impurities are hidden in the small intestine fragments and cannot be exposed in an extraction solution to be subjected to impurity removal treatment and adsorbed is solved, and it is ensured that the extraction solution entering the next procedure does not affect the purity of a final heparin sodium product.

Description

Technical Field

[0001] The invention relates to the technical field of heparin sodium processing, and in particular to an impurity removal device for the production and processing of crude heparin sodium. Background Art

[0002] Heparin sodium is a glycosaminoglycan anticoagulant drug extracted from the pig small intestinal mucosa. It is widely used in clinical situations where an anticoagulant effect needs to be achieved quickly. However, during the extraction process, crude heparin sodium often contains a variety of impurities, including proteins, nucleic acids, and structurally similar polysulfated chondroitin. These impurities not only affect the purity and efficacy of the drug, but also cause serious adverse reactions.

[0003] In the production and processing of crude sodium heparin, first, animal mucosa that meets the quality standards needs to be selected, and then the mucosal tissue is crushed so that the heparin molecules can be more fully contacted with the extraction solution, and then a specific solution is added for dissolution reaction to extract the heparin from the animal mucosa. Then, during the extraction process, impurities in the production and processing are removed by ion adsorption technology. However, in the existing production and processing of crude sodium heparin, the mucosal tissue is usually directly crushed by a mincing component to form an extraction solution, which is then poured into the impurity removal component. Insufficient mincing causes the large particle structure of the mucosal tissue to limit the release of heparin molecules, so that impurities cannot be fully exposed to the extraction solution. After the extraction solution in this state is subjected to ion adsorption and impurity removal, only the impurities in the extraction solution can be removed, and the impurities existing in the raw material will enter the next process, which ultimately affects the purity and quality of the sodium heparin product. Based on this, the present invention purposely provides an impurity removal device for the production and processing of crude sodium heparin, which can fully expose the impurities in the raw material solution to the extraction solution and be treated by ion adsorption and impurity removal. Summary of the invention

[0004] The purpose of the present invention is to provide an impurity removal device for the production and processing of crude heparin sodium in view of the shortcomings of the prior art, so as to solve the technical problem in the prior art that impurities still exist in the raw material after the raw material solution is minced and cannot be fully exposed to the extraction solution, resulting in poor impurity removal effect.

[0005] The purpose of the present invention can be achieved through the following technical solutions: An impurity removal device for the production and processing of crude heparin sodium, comprising: A mounting platform, and an auger blade is rotatably mounted on it, the auger blade is driven to rotate by a driving source, and its edge is slidably matched with the inner wall of a feed barrel fixed on the mounting platform, the bottom end of the feed barrel is connected with a feed barrel, a movable sleeve is provided on the mounting platform, and the movable sleeve is sleeved on the outer cylindrical surface of the feed barrel, a cavity exists between the movable sleeve and the feed barrel, the bottom of the movable sleeve is connected with a discharge pipe, a debris removal component is provided on the feed barrel, the debris removal component is located below the movable sleeve, and its feed end is matched with the discharge pipe, the discharge end of the debris removal component is connected with a reflux pipe and a discharge pipe through a cut-off three-way valve, and it is connected with a detection component, and the reflux pipe is connected with the feed barrel; An outer ring is rotatably mounted on the top of the mounting platform and driven to rotate by the second driving assembly. The inner wall of the outer ring is inclined, and the inner radius of the outer ring decreases downward along its axial direction; and The inner ring is slidably mounted on the top of the feed barrel and is located above the movable sleeve. A plurality of raised blades are fixedly mounted on the outer surface of the inner ring and the inner wall of the outer ring. The inner ring is driven to rise and fall by the first output source built into the feed barrel, and there is a gap between the inner ring and the outer ring, which is connected to the cavity. The first output source is connected to the detection component. In the initial state of the inner ring, the horizontal height of the bottom end of the inner ring is higher than the horizontal height of the bottom end of the outer ring.

[0006] As a further solution of the present invention: the movable sleeve is rotatably installed on the mounting table, and is driven to rotate by the first driving component. There are multiple impurity removal components and detection components, and the multiple impurity removal components are arranged circumferentially. Each impurity removal component includes an ion exchange column and a temporary storage tank. The ion exchange column and the temporary storage tank are fixedly installed on the outer cylindrical surface of the feed cylinder, and the two are connected. The feed end of the ion exchange column is connected to the funnel, and the funnel cooperates with the discharge pipe. The discharge end of the temporary storage tank is connected to the reflux pipe and the discharge pipe through a shut-off three-way valve, and a corresponding detection component is fixedly installed in each temporary storage tank.

[0007] As a further solution of the present invention: the raised blades are arranged obliquely, and the inclined direction of the raised blades on the inner ring is opposite to the inclined direction of the raised blades on the outer ring.

[0008] As a further solution of the present invention: the bottom plate of the movable sleeve is arranged obliquely, and the discharge pipe is arranged at a lower level of the bottom of the movable sleeve.

[0009] As a further solution of the present invention: a plurality of diverter rods are fixedly connected to the outer circumferential surface of the feeding cylinder, the plurality of diverter rods are arranged circumferentially, and are located in the cavity between the movable sleeve and the feeding cylinder.

[0010] As a further solution of the present invention: a telescopic cylinder is slidably sleeved on the bottom end of the discharge pipe, and the telescopic cylinder is driven to rise and fall by a second output source built into the discharge pipe, and is in abutment with the inner wall of the funnel.

[0011] As a further solution of the present invention: an umbrella-shaped platform is fixedly connected to the top of the feeding cylinder, and the edge of the umbrella-shaped platform faces the gap between the inner ring and the outer ring.

[0012] As a further solution of the present invention: a splash shield is fixedly connected to the top surface of the outer ring, a horizontal section of the splash shield has a height higher than a discharge end of the feed barrel, and a conical ring is fixedly mounted on the splash shield.

[0013] Beneficial effects of the present invention: 1. In the present invention, the gap between the outer ring and the inner ring should be an inverted right-angled trapezoidal shape from the cross-section, which means that the small intestine will gradually be minced into small pieces during the falling process. By detecting the extraction solution after the impurity removal treatment, the larger small intestine fragments contained in the solution can be found in time, so as to adjust the descent of the inner ring so that it and the outer ring can mince the small intestine fragments that failed to be minced last time, avoiding the problem that too many impurities are hidden in the small intestine fragments and cannot be exposed to the extraction solution and adsorbed by the impurity removal treatment, thereby ensuring that the extraction solution entering the next process will not affect the purity of the final heparin sodium product; 2. In the present invention, by setting up multiple ion exchange columns, an extraction solution can be divided more finely, and multiple groups of extraction solutions can be simultaneously subjected to impurity removal and subsequent testing, thereby improving the impurity removal efficiency and gradually delivering qualified solutions to the next process in a timely manner, thereby avoiding unqualified impurity removal due to the presence of large small intestine fragments in the extraction solution, thereby causing all the extraction solutions to enter the next mincing and impurity removal process; 3. In the present invention, the raised blades on the inner ring are inclined in the opposite direction to the raised blades on the outer ring, so that the effective areas of the two are larger and the cutting ability generated by the rotation of the outer ring is stronger, thereby avoiding untimely cutting of the small intestine and causing blockage. Compared with the raised blades inclined in a single direction, the raised blades inclined in the opposite direction can better grind the small intestine into fine particles, which improves the cutting effect and makes it easier to expose impurities in the raw material solution, which is beneficial to the subsequent adsorption of impurities in the raw material solution by the ion exchange column. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The present invention will be further described below in conjunction with the accompanying drawings.

[0015] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the outer ring splitting structure in the present invention; Figure 3 It is a schematic diagram of the cross-sectional structure of the upper part of the material conveying pipe in the present invention; Figure 4It is a structural schematic diagram of the feeding tube in the present invention; Figure 5 It is a structural schematic diagram of the discharge pipe in the present invention.

[0016] In the figure: 1. mounting table; 2. feed cylinder; 201. feed cylinder; 202. umbrella-shaped table; 3. auger blade; 4. inner ring; 5. outer ring; 6. movable sleeve; 7. discharge pipe; 701. telescopic cylinder; 8. ion exchange column; 801. funnel; 9. temporary storage tank; 10. reflux pipe; 11. discharge pipe; 12. raised blade; 13. diverter rod; 14. splash guard; 15. conical ring. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] See also Figure 1-Figure 5 As shown, the present invention is an impurity removal device for the production and processing of crude heparin sodium, comprising: A mounting platform 1 is provided, and an auger blade 3 is rotatably mounted thereon, the auger blade 3 is driven to rotate by a driving source, and its edge is slidably matched with the inner wall of the feed barrel 2 fixed on the mounting platform 1, the bottom end of the feed barrel 2 is connected with the feed barrel 201, a movable sleeve 6 is provided on the mounting platform 1, and it is sleeved on the outer cylindrical surface of the feed barrel 2, there is a cavity between the movable sleeve 6 and the feed barrel 2, the bottom of the movable sleeve 6 is connected with the discharge pipe 7, a debris removal component is provided on the feed barrel 2, the debris removal component is located below the movable sleeve 6, and its feed end is matched with the discharge pipe 7, the discharge end of the debris removal component is connected with the return pipe 10 and the discharge pipe 11 through a cut-off three-way valve, and it is connected to the detection component, and the return pipe 10 is connected with the feed barrel 2; An outer ring 5 is rotatably mounted on the top of the mounting platform 1 and driven to rotate by the second driving assembly. The inner wall of the outer ring 5 is inclined, and the inner radius of the outer ring 5 decreases downward along its axial direction; and The inner ring 4 is slidably mounted on the top of the feed barrel 2 and is located above the movable sleeve 6. A plurality of raised blades 12 are fixedly mounted on the outer surface of the inner ring 4 and the inner wall of the outer ring 5. The inner ring 4 is driven to rise and fall by the first output source built into the feed barrel 2, and there is a gap between it and the outer ring 5, which is connected to the cavity. The first output source is connected to the detection component. In the initial state of the inner ring 4, the horizontal height of the bottom end of the inner ring 4 is higher than the horizontal height of the bottom end of the outer ring 5.

[0019] In one case of this embodiment, the driving source can be a servo motor, servo motor and other components, the first output source can be a hydraulic rod, an electric cylinder and other components, the second driving assembly can be a pulley assembly, a gear assembly driven by a motor, etc., and this embodiment does not make specific limitations here; the detection assembly includes a PLC control system, a UV-visible spectrophotometer sensor, a signal receiving / transmitting module, etc. The above components are all prior arts, and the present invention does not improve them. Therefore, there is no need to disclose their specific mechanical structure and circuit structure, and it does not affect the integrity of the present invention.

[0020] In actual application of this embodiment, firstly, clean small intestines and a certain proportion of water are mixed into a raw material solution, and an appropriate amount of industrial salt is added to adjust the pH value of the raw material solution to 8-9, and the raw material solution is transported into the feed barrel 2 through the feed barrel 201, and the raw material solution is vertically transported upward through the auger blade 3 until it gushes out from the top of the feed barrel 2, and diffuses to the surroundings and falls into the gap between the inner ring 4 and the outer ring 5, and the outer ring 5 continues to rotate under the action of the second drive component, and the small intestine in the gap will be continuously cut and broken by the raised blade 12. At this time, the inner ring 4 is in the initial state, and the inner wall of the outer ring 5 is designed to be inclined. From the cross-section, the gap between the outer ring 5 and the inner ring 4 should be an inverted right-angled trapezoid, which means that the small intestine will gradually be minced into small pieces during the falling process; The minced raw material solution falls into the movable sleeve 6. At this time, the extraction solution in the movable sleeve 6 contains the impurities exposed by the minced small intestine. The extraction solution is then transported to the impurity removal component through the discharge pipe 7 for impurity removal. The extracted solution after impurity removal receives the detection of the detection component to detect whether the impurities in the extraction solution exceed the threshold value and whether the small intestine fragments are larger than the threshold value. If both test results are less than the threshold value, the discharge pipe 11 is opened through the three-way stop valve, the reflux pipe 10 is closed, and the qualified extraction solution is transported to the next process; otherwise, the reflux pipe 10 is opened, the discharge pipe 11 is closed, and the unqualified extraction solution is re-transported into the feed barrel 2, and the detection component will control the first output source to make the inner ring 4 descend, which means that the gap between the bottom of the inner ring 4 and the outer ring 5 will be reduced. In the next mincing process, the larger small intestine fragments will be minced more thoroughly, thereby exposing the impurities in the small intestine to the extraction solution, until they are qualified in a certain two tests, they can be transported to the next process.

[0021] like Figure 3As shown, as a preferred embodiment of the present invention, the movable sleeve 6 is rotatably mounted on the mounting table 1, and is driven to rotate by the first driving component. The number of the impurity removal components and the detection components are both multiple, and the multiple impurity removal components are arranged circumferentially. Each impurity removal component includes an ion exchange column 8 and a temporary storage tank 9, and the ion exchange column 8 and the temporary storage tank 9 are fixedly mounted on the outer cylindrical surface of the feed barrel 2, and the two are connected. The feed end of the ion exchange column 8 is connected to the funnel 801, and the funnel 801 cooperates with the discharge pipe 7. The discharge end of the temporary storage tank 9 is connected to the reflux pipe 10 and the discharge pipe 11 through a shut-off three-way valve, and a corresponding detection component is fixedly installed in each temporary storage tank 9.

[0022] In one case of this embodiment, the first driving assembly may be a pulley assembly, a gear assembly driven by a motor, etc., which is not specifically limited in this embodiment.

[0023] In actual application of this embodiment, the rotation of the movable sleeve 6 will continuously stir and mix the minced extraction solution, so that impurities are more fully exposed in the extraction solution, and when the discharge pipe 7 is aligned with the funnel 801 in turn, the extraction solution is injected into the ion exchange column 8, and the solution after ion adsorption is injected into the temporary storage tank 9 for temporary storage. During this period, the extraction solution is detected by the detection component to see whether it meets the standard. In this way, through the arrangement of multiple ion exchange columns 8, a portion of extraction solution can be divided more finely, and multiple groups of extraction solutions can be removed and subsequently detected at the same time, which improves the removal efficiency and can gradually remove qualified solutions to the next process in time, so as to avoid all extraction solutions entering the next mincing and removal process due to poor local removal effect.

[0024] like Figure 3 As shown, as a preferred embodiment of the present invention, the raised blades 12 are arranged obliquely, and the inclined direction of the raised blades 12 on the inner ring 4 is opposite to the inclined direction of the raised blades 12 on the outer ring 5.

[0025] In actual application of this embodiment, the raised blade 12 on the inner ring 4 is inclined in the opposite direction to the raised blade 12 on the outer ring 5, so that the effective area of ​​the two is larger, and the cutting ability generated by the rotation of the outer ring 5 is also stronger, thereby avoiding untimely cutting of the small intestine and causing blockage. Compared with the raised blade 12 inclined in a single direction, the raised blade 12 inclined in the opposite direction can better grind the small intestine into fine particles, which improves the cutting effect and makes it easier to expose impurities in the raw material solution, which is beneficial to the subsequent adsorption of impurities in the extraction solution by the ion exchange column 8.

[0026] like Figure 2-Figure 3 As shown, as a preferred embodiment of the present invention, the bottom plate of the movable sleeve 6 is arranged obliquely, and the discharge pipe 7 is arranged at a lower horizontal height of the bottom of the movable sleeve 6.

[0027] In actual application of this embodiment, the bottom plate of the movable sleeve 6 is tilted so that the extraction solution falling into the movable sleeve 6 is concentrated at a lower horizontal height. At the same time, the discharge pipe 7 is arranged at a lower horizontal height at the bottom of the movable sleeve 6, so that it is convenient for the extraction solution to be discharged through the discharge pipe 7, avoiding the situation where the extraction solution is easily left on the bottom plate of the movable sleeve 6 when the bottom plate is arranged horizontally.

[0028] like Figure 2-Figure 3 As shown, as a preferred embodiment of the present invention, a plurality of diverter rods 13 are fixedly connected to the outer circumferential surface of the feeding cylinder 2 , and the plurality of diverter rods 13 are arranged circumferentially and are located in the cavity between the movable sleeve 6 and the feeding cylinder 2 .

[0029] In actual application of this embodiment, the rotation of the movable sleeve 6 will drive the extraction solution inside it to tumble and mix, and a diverter rod 13 is installed on the outer cylindrical surface of the feeding barrel 2, so that the extraction solution will hit the diverter rod 13 when tumbling, and will be cut by the diverter rod 13, thereby further achieving the effect of crushing impurities in the extraction solution, and at the same time, the mixing degree of the extraction solution is also improved, thereby improving the efficiency of the ion exchange column 8 in removing impurities from the uniformly mixed extraction solution.

[0030] like Figure 5 As shown, as a preferred embodiment of the present invention, a telescopic cylinder 701 is slidably sleeved on the bottom end of the discharge pipe 7, and the telescopic cylinder 701 is driven to rise and fall by a second output source built into the discharge pipe 7, and is in abutment with the inner wall of the funnel 801.

[0031] In one case of this embodiment, the second output source may be an electric cylinder, an electric telescopic rod or other components, or other mechanisms capable of achieving lifting motion, which is not specifically limited in this embodiment.

[0032] In actual application of this embodiment, before it is necessary to open the discharge pipe 7 and discharge the extraction solution in the movable sleeve 6 into the funnel 801, the telescopic cylinder 701 is first controlled to descend through the second output source, so that the telescopic cylinder 701 slides on the discharge pipe 7, and its bottom end will abut against the inner wall of the funnel 801, thereby establishing a closed connection channel between the discharge pipe 7 and the funnel 801. In this way, the extraction solution is transported to the funnel 801 through the telescopic cylinder 701, avoiding the existence of a gap between the telescopic cylinder 701 and the funnel 801, which will cause material to be scattered during discharge.

[0033] like Figure 1-Figure 4 As shown, as a preferred embodiment of the present invention, an umbrella-shaped platform 202 is fixedly connected to the top of the feeding cylinder 2, and the edge of the umbrella-shaped platform 202 faces the gap between the inner ring 4 and the outer ring 5.

[0034] In actual application of this embodiment, the setting of the umbrella-shaped platform 202 allows the raw material solution to slide along the inclined surface of the umbrella-shaped platform 202 to the gap between the inner ring 4 and the outer ring 5 when it flows out through the liquid outlet of the feeding tube 2, and in the process of sliding, the dispersion of the raw material solution will be more uniform, avoiding the phenomenon of local aggregation when the raw material solution flows out.

[0035] like Figure 1-Figure 3 As shown, as a preferred embodiment of the present invention, the top surface of the outer ring 5 is fixedly connected to a splash shield 14 , the horizontal section of the splash shield 14 is higher than the discharge end of the feed barrel 2 , and a conical ring 15 is fixedly mounted on the splash shield 14 .

[0036] In actual application of this embodiment, the splash shield 14 can prevent the small intestine from splashing outward during the mincing process, and the setting of the conical ring 15 further expands the shielding range, and the raw materials intercepted by the conical ring 15 will slide along its inner wall to the gap between the inner ring 4 and the outer ring 5.

[0037] The working principle of the present invention is as follows: the minced raw material solution falls into the movable sleeve 6. At this time, the extraction solution in the movable sleeve 6 contains the impurities exposed by the minced small intestine. Then, the extraction solution is transported to the impurity removal component through the discharge pipe 7 for impurity removal. The extracted solution after impurity removal receives the detection of the detection component to detect whether the impurities in the extracted solution exceed the threshold value and whether the small intestine fragments are larger than the threshold value. If both detection results are less than the threshold value, the discharge pipe 11 is opened through the three-way stop valve, the reflux pipe 10 is closed, and the qualified extraction solution is transported to the next process; otherwise, the reflux pipe 10 is opened, the discharge pipe 11 is closed, and the unqualified extraction solution is re-transported into the feed barrel 2, and the detection component will control the first output source to make the inner ring 4 descend, which means that the gap between the bottom of the inner ring 4 and the outer ring 5 will be reduced. In the next mincing process, the larger small intestine fragments will be minced more thoroughly, thereby exposing the impurities in the small intestine to the extraction solution, until they are qualified in a certain two tests, they can be transported to the next process.

[0038] The above is a detailed description of an embodiment of the present invention, but the content is only a preferred embodiment of the present invention and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. An impurity removal device for the production and processing of crude heparin sodium, characterized in that: include: A mounting platform (1) is provided on which an auger blade (3) is rotatably mounted. The auger blade (3) is driven to rotate by a driving source, and its edge is slidably matched with the inner wall of a feed barrel (2) fixed on the mounting platform (1). The bottom end of the feed barrel (2) is connected to the feed barrel (201). A movable sleeve (6) is provided on the mounting platform (1) and is sleeved on the outer circumferential surface of the feed barrel (2). A cavity exists between the movable sleeve (6) and the feed barrel (2). The bottom of the movable sleeve (6) is connected to the discharge pipe (7). A debris removal component is provided on the feed barrel (2). The debris removal component is located below the movable sleeve (6), and its feed end is matched with the discharge pipe (7). The discharge end of the debris removal component is connected to the return pipe (10) and the discharge pipe (11) through a stop three-way valve, and is connected to the detection component. The return pipe (10) is connected to the feed barrel (2); An outer ring (5) is rotatably mounted on the top of the mounting platform (1) and is driven to rotate by a second driving assembly. The inner wall of the outer ring (5) is designed to be inclined, and the inner radius of the outer ring (5) decreases downward along its axial direction. as well as The inner ring (4) is slidably mounted on the top of the feed barrel (2) and is located above the movable sleeve (6). A plurality of raised blades (12) are fixedly mounted on the outer surface of the inner ring (4) and the inner wall of the outer ring (5). The inner ring (4) is driven to rise and fall by a first output source built into the feed barrel (2). There is a gap between the inner ring (4) and the outer ring (5), and the gap is connected to the cavity. The first output source is connected to the detection component. When the inner ring (4) is in an initial state, the horizontal height of the bottom end of the inner ring (4) is higher than the horizontal height of the bottom end of the outer ring (5).

2. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: The movable sleeve (6) is rotatably mounted on the mounting platform (1) and is driven to rotate by the first driving assembly. The impurity removal assembly and the detection assembly are both multiple in number and are arranged circumferentially. Each impurity removal assembly comprises an ion exchange column (8) and a temporary storage tank (9). The ion exchange column (8) and the temporary storage tank (9) are both fixedly mounted on the outer cylindrical surface of the feeding cylinder (2) and are in communication with each other. The feed end of the ion exchange column (8) is in communication with the funnel (801), and the funnel (801) cooperates with the discharge pipe (7). The discharge end of the temporary storage tank (9) is in communication with the reflux pipe (10) and the discharge pipe (11) via a three-way stop valve. A corresponding detection assembly is fixedly mounted in each temporary storage tank (9).

3. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: The raised blades (12) are arranged in an inclined manner, and the inclined direction of the raised blades (12) on the inner ring (4) is opposite to the inclined direction of the raised blades (12) on the outer ring (5).

4. The impurity removal device for the production and processing of crude heparin sodium according to claim 2, characterized in that: The bottom plate of the movable sleeve (6) is arranged obliquely, and the discharge pipe (7) is arranged at a lower level of the bottom of the movable sleeve (6).

5. The impurity removal device for the production and processing of crude heparin sodium according to claim 2, characterized in that: A plurality of diverter rods (13) are fixedly connected to the outer circumferential surface of the material delivery cylinder (2); the plurality of diverter rods (13) are arranged circumferentially and are located in a cavity between the movable sleeve (6) and the material delivery cylinder (2).

6. The impurity removal device for the production and processing of crude heparin sodium according to claim 2, characterized in that: The bottom end of the discharge pipe (7) is slidably sleeved with a telescopic cylinder (701), the telescopic cylinder (701) is driven to rise and fall by a second output source built into the discharge pipe (7), and is in abutment with the inner wall of the funnel (801).

7. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: An umbrella-shaped platform (202) is fixedly connected to the top of the feeding cylinder (2), and the edge of the umbrella-shaped platform (202) faces the gap between the inner circular ring (4) and the outer circular ring (5).

8. The impurity removal device for the production and processing of crude heparin sodium according to claim 1, characterized in that: The top surface of the outer ring (5) is fixedly connected to a splash shield (14), the horizontal section of the splash shield (14) is higher than the discharge end of the feed barrel (2), and a conical ring (15) is fixedly mounted on the splash shield (14).

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