Copper-based antibacterial material prepared by compounding and modifying nano-copper as well as preparation method and application of copper-based antibacterial material

Abstract

The invention relates to a copper-based antibacterial material prepared by compounding and modifying nano-copper and a preparation method and application of the copper-based antibacterial material, compound powder formed by compounding and modifying nano-copper is compounded and mixed with a polypropylene material to manufacture a copper-based antibacterial eye drop device, and the antibacterial eye drop device can effectively prolong the storage time of stored eye drops; therefore, the addition amount of preservatives in the eye drops is reduced, and the harm to human bodies is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedical materials, and in particular to a copper-based antibacterial material prepared by composite modification of nano-copper, and a preparation method and application thereof. Background Art

[0002] In order to extend the effective time of existing eye drops, a large amount of preservatives are often added to the eye drops to increase the shelf life of the eye drops. However, a large amount of preservatives are often harmful to the human body. Therefore, there is an urgent need for a method of increasing the shelf life of eye drops by improving the container for storing eye drops. Summary of the invention

[0003] In order to solve the shortcomings of the prior art, the present invention provides a copper-based antibacterial material prepared by composite modification of nano-copper, and a preparation method and application thereof.

[0004] The technical solution adopted by the present invention is: a copper-based antibacterial material is prepared by using nano-copper compound modification, and the copper-based antibacterial material is composed of 5% by mass of nano-copper compound modified material and 95% of polypropylene (PP).

[0005] Specifically, the nano-copper composite modified material is prepared from nano-cuprous oxide, nano-zinc oxide, PEG6000 and porous silica.

[0006] Specifically, the nano cuprous oxide is 100 nanometers of cuprous oxide.

[0007] Specifically, the nano zinc oxide is 20 nanometers of cuprous oxide.

[0008] Specifically, the porous silica is 1 micron porous silica.

[0009] The nano copper composite modified material is prepared by the following steps: (1) Take Dow PEG6000, heat it to 100°C, maintain constant temperature, ensure that the solid melts into the liquid, stir at 70 rpm, and after the solid is completely melted, adjust the stirring speed to 280 rpm, and stir for 15 minutes after melting; (2) Take 20 nanometers of zinc oxide and 1 micron of porous silica, place them on a mesh screen, and gradually vibrate them to allow the zinc oxide to slowly and evenly fall into the stirring PEG solution. Control the stirring speed to 200 rpm. After stirring for 5 minutes, adjust it to 600 rpm. (3) Take 100 nanometer cuprous oxide material, place it on a mesh screen, and gradually vibrate it to allow zinc oxide to slowly and evenly fall into the stirring PEG solution. Control the stirring speed to 200 rpm. After stirring for 15 minutes, adjust it to 300 rpm. After stirring for 15 minutes, adjust it to 600 rpm and stir for 15 minutes. (4) Cool the container of PEG6000, nano-zinc and nano-cuprous oxide mixed solution to 45°C and stir at 300 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 35°C and stir at 100 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 25°C and stir at 60 rpm for 5 minutes. When the mixed solution solidifies, drain it into a plastic box; (5) After the mixture is completely solidified, it is crushed into powder and then pulverized to a particle size of 2 microns.

[0010] Specifically, the mesh screen is a 5000 mesh metal mesh screen.

[0011] Specifically, the content ratio of nano cuprous oxide, nano zinc oxide, PEG6000 and porous silicon dioxide in the nano copper composite modified material is 15-25:5-15:59:1.

[0012] A method for preparing a copper-based antibacterial material by using nano-copper compound modification and its application in a device for preparing antibacterial eye drops.

[0013] The antibacterial eye drop device is prepared by the following steps: (1) The nano-copper composite modified material powder and polypropylene (PP) particles are placed together for mixing and crushing. After crushing for 20 minutes, a powder of the nano-copper composite modified material powder and polypropylene (PP) is formed, which is uniformly mixed, and the powder level is 2 microns; (2) The powder is injected into an injection mold to obtain a copper-based antibacterial eye drop device.

[0014] The beneficial effects of the present invention are as follows: the present invention provides a copper-based antibacterial material prepared by composite modification of nano-copper, a preparation method and application thereof, a copper-based antibacterial eye drop device is manufactured by compositely modifying nano-copper to form a composite powder and compositely mixing with a polypropylene material, and the antibacterial eye drop device can effectively prolong the shelf life of the stored eye drops, thereby reducing the amount of preservatives added in the eye drops and reducing harm to the human body. DETAILED DESCRIPTION

[0015] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] Example 1: Preparation of nano-copper composite modified material Jinghe Nano: 100 nanometers of cuprous oxide: 15% Zhongxing New Materials: 20 nanometer zinc oxide: 5% Dow: PEG6000: 59%; Zhongke Keyou: Porous silica (1 micron) 1% Process: (1) Take 60 g of Dow PEG6000 and heat it to 100°C. Keep the temperature constant to ensure that the solid melts into the liquid. At the beginning, the stirrer speed is 70 rpm. After the solid is completely melted, the stirrer speed is 280 rpm). Stir for 15 minutes after melting.

[0017] (2) Take 5 g of 20-nanometer zinc oxide from Zhongxing New Materials and porous silica (1 μm, 1 g) provided by Zhongke Keyou, place them on a 5000-mesh metal sieve, and gradually vibrate to allow the zinc oxide to slowly and evenly fall into the stirring PEG solution. Adjust the mixer speed to 200 rpm. After stirring for 5 minutes, adjust to 600 rpm.

[0018] (3) Take 15 g of Jinghe Nano 100 nanometer cuprous oxide material, place it on a 5000 mesh metal screen, and gradually vibrate it to allow the zinc oxide to slowly and evenly fall into the stirring PEG solution. Adjust the mixer speed to 200 rpm, stir for 15 minutes, then adjust to 300 rpm, stir for 15 minutes, and then adjust to 600 rpm and stir for 15 minutes.

[0019] (4) Cool the container of PEG6000, nano-zinc and nano-cuprous oxide mixed solution to 45°C, and adjust the stirrer to 300 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 35°C, and adjust the stirrer to 100 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 25°C, and adjust the stirrer to 60 rpm for 5 minutes. When the solution solidifies, drain the mixed solution into a plastic box; (5) After the mixture is completely solidified, it is crushed into powder and then crushed into a particle size of 2 microns using Weifang Jinghua Ultrafine Grinding Equipment (CR Series).

[0020] Example 2: Preparation of nano-copper composite modified materials Jinghe Nano: 100 nanometers of cuprous oxide: 25% Zhongxing New Materials: 20 nanometer zinc oxide: 15% Dow: PEG6000: 59%; Zhongke Keyou: Porous silica (1 micron) 1% Process: (1) Take 60 g of Dow PEG6000 and heat it to 100°C. Keep the temperature constant to ensure that the solid melts into the liquid. At the beginning, the stirrer speed is 70 rpm. After the solid is completely melted, the stirrer speed is 280 rpm). Stir for 15 minutes after melting.

[0021] (2) Take 5 g of 20-nanometer zinc oxide from Zhongxing New Materials and porous silica (1 μm, 1 g) provided by Zhongke Keyou, place them on a 5000-mesh metal sieve, and gradually vibrate to allow the zinc oxide to slowly and evenly fall into the stirring PEG solution. Adjust the mixer speed to 200 rpm. After stirring for 5 minutes, adjust to 600 rpm.

[0022] (3) Take 15 g of Jinghe Nano 100 nanometer cuprous oxide material, place it on a 5000 mesh metal screen, and gradually vibrate it to allow the zinc oxide to slowly and evenly fall into the stirring PEG solution. Adjust the mixer speed to 200 rpm, stir for 15 minutes, then adjust to 300 rpm, stir for 15 minutes, and then adjust to 600 rpm and stir for 15 minutes.

[0023] (4) Cool the container of PEG6000, nano-zinc and nano-cuprous oxide mixed solution to 45°C, and adjust the stirrer to 300 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 35°C, and adjust the stirrer to 100 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 25°C, and adjust the stirrer to 60 rpm for 5 minutes. When the solution solidifies, drain the mixed solution into a plastic box; (5) After the mixture is completely solidified, it is crushed into powder and then crushed into a particle size of 2 microns using Weifang Jinghua Ultrafine Grinding Equipment (CR Series).

[0024] Example 3: Nano-copper compound modified powder + polypropylene (PP) mixed material to manufacture copper-based antibacterial eye drops bottle formula: Example 1 Preparation of composite nano-modified powder: 5% Polypropylene (PP) particles: 95% Process: (1) Compound nano-modified powder 50g, polypropylene (PP) particles: 950g; (2) The two components are placed together and mixed and crushed in Weifang Jinghua Ultrafine Grinding Equipment (CR Series). After 20 minutes of crushing, a powder uniformly mixed with composite nano-modified powder and polypropylene (PP) is formed, and the powder level is 2 microns.

[0025] (3) The powder is injected into a mold to form a copper-based antibacterial eye drop bottle.

[0026] Example 4: Nano-copper composite modified powder + polypropylene (PP) mixed material to manufacture copper-based antibacterial eye drops bottle formula: Example 2 Preparation of composite nano-modified powder: 5% Polypropylene (PP) particles: 95% Process: (1) Compound nano-modified powder 50g, polypropylene (PP) particles: 950g; (2) The two components are placed together and mixed and crushed in Weifang Jinghua Ultrafine Grinding Equipment (CR Series). After 20 minutes of crushing, a powder uniformly mixed with composite nano-modified powder and polypropylene (PP) is formed, and the powder level is 2 microns.

[0027] (3) The powder is injected into a mold to form a copper-based antibacterial eye drop bottle.

[0028] Comparative Example 5: Polypropylene (PP) eye drop bottle Process: (1) Polypropylene (PP) particles: 1000g; (2) Weifang Jinghua Ultrafine Grinding Equipment (CR Series) performs mixed crushing. After 20 minutes of crushing, powder is formed with a powder level of 2 microns.

[0029] (3) The powder is injected into a mold to form a polypropylene (PP) eye drop bottle.

[0030] The relevant properties of the eye drop bottles prepared in Examples 3-4 and Comparative Example 5 were tested, and the obtained data are recorded in the following table:

[0031] By comparing the relevant data in the analysis table, it can be seen that the copper-based antibacterial material prepared by the composite modification of the prepared nano-copper and the prepared eye drop bottle can effectively sterilize the eye drops in the eye drop bottle and effectively increase the shelf life of the eye drops.

[0032] The above are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should be regarded as the protection scope of the present invention.

[0033] Technical personnel should note that although the present invention has been described according to the above specific implementation methods, the inventive concept of the present invention is not limited to this invention, and any modification using the inventive concept will be included in the scope of protection of this patent.

Claims

1. A method for preparing a copper-based antibacterial material by using nano-copper compound modification, characterized in that: The copper-based antibacterial material is composed of 5% by mass of a nano-copper composite modified material and 95% by mass of polypropylene (PP).

2. The method for preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 1, characterized in that: The nano copper composite modified material is prepared from nano cuprous oxide, nano zinc oxide, PEG6000 and porous silicon dioxide.

3. The method for preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 2, characterized in that: The nano cuprous oxide is 100 nanometers of cuprous oxide.

4. The method for preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 2, characterized in that: The nano zinc oxide is 20 nanometer cuprous oxide.

5. The method for preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 2, characterized in that: The porous silica is 1 micron porous silica.

6. The method for preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 2, characterized in that: The nano copper composite modified material is prepared by the following steps: (1) Take Dow PEG6000, heat it to 100°C, maintain constant temperature, ensure that the solid melts into the liquid, stir at 70 rpm, and after the solid is completely melted, adjust the stirring speed to 280 rpm, and stir for 15 minutes after melting; (2) Take 20 nanometers of zinc oxide and 1 micron of porous silica, place them on a mesh screen, and gradually vibrate them to allow the zinc oxide to slowly and evenly fall into the stirring PEG solution. Control the stirring speed to 200 rpm. After stirring for 5 minutes, adjust it to 600 rpm. (3) Take 100 nanometer cuprous oxide material, place it on a mesh screen, and gradually vibrate it to allow zinc oxide to slowly and evenly fall into the stirring PEG solution. Control the stirring speed to 200 rpm. After stirring for 15 minutes, adjust it to 300 rpm. After stirring for 15 minutes, adjust it to 600 rpm and stir for 15 minutes. (4) Cool the container of PEG6000, nano-zinc and nano-cuprous oxide mixed solution to 45°C and stir at 300 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 35°C and stir at 100 rpm for 5 minutes; then cool the container of nano-cuprous oxide mixed solution to 25°C and stir at 60 rpm for 5 minutes. When the mixed solution solidifies, drain it into a plastic box; (5) After the mixture is completely solidified, it is crushed into powder and then pulverized to a particle size of 2 microns.

7. The method for preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 1, characterized in that: The mesh screen is a 5000-mesh metal mesh screen.

8. The method of preparing a copper-based antibacterial material by compounding and modifying nano-copper according to claim 6, characterized in that: The content ratio of nano cuprous oxide, nano zinc oxide, PEG6000 and porous silicon dioxide in the nano copper composite modified material is 15-25:5-15:59:

1.

9. Use of the copper-based antibacterial material prepared by composite modification of nano-copper as claimed in claim 1 in a device for preparing antibacterial eye drops.

10. The use according to claim 9, characterized in that: The antibacterial eye drop device is prepared by the following steps: (1) The nano-copper composite modified material powder and polypropylene (PP) particles are placed together for mixing and crushing. After crushing for 20 minutes, a powder of the nano-copper composite modified material powder and polypropylene (PP) is formed, which is uniformly mixed, and the powder level is 2 microns; (2) The powder is injected into an injection mold to obtain a copper-based antibacterial eye drop device.

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