Novel preparation for improving toughness and / or elasticity of hair

Abstract

The present invention addresses the problem of providing a novel preparation and the like for improving the toughness and / or elasticity of hair. The technical scheme for solving the technical problem is as follows: the preparation for improving the toughness and / or elasticity of hair contains hemin as an effective component.

Description

Cross Reference

[0001] This application claims priority based on Japanese Patent Application No. 2022-086087 filed on May 26, 2022, and Japanese Patent Application No. 2023-001532 filed on January 10, 2023, and all the contents described in these applications are directly cited in this specification by reference. Technical Field

[0002] The present invention relates to a preparation and the like for improving the toughness and / or elasticity of hair for use in humans and the like. Background Art

[0003] Hair largely determines a person's appearance, so it occupies a very important position in beauty. Hair is mainly composed of a stratum corneum covering the surface, a cortex located inside and occupying most of the hair, and a medulla existing in the center of the hair. Among them, the stratum corneum adopts a scale-like structure stacked from the root to the end of the hair, which plays a role in protecting the inside of the hair from the outside. In recent years, the structural analysis of the stratum corneum has been continuously developed, and it is known that the outermost layer of the stratum corneum has a structure in which a long-chain fatty acid called 18-methyleicosanoic acid is chemically bonded to hair protein. Hair is constantly damaged (damage) due to chemical treatments such as perming, bleaching, and hair dyeing, ultraviolet rays generated by sunlight, heat generated by a hair dryer, combing, etc. It is known that when hair is damaged in this way, the long-chain fatty acids on the surface of the stratum corneum will detach, and the damage to the surface of the stratum corneum makes the smoothness of the hair and the combing property of the fingers worse, which becomes one of the main reasons for feeling hair damage. As a method for improving such hair damage, a method of using long-chain fatty acids and quaternary compounds of long-chain fatty acids has been tried. However, in these methods, the components are washed out by daily shampooing, etc., and it is difficult to maintain the effects for a long time (Patent Document 1).

[0004] As a preparation that can alleviate hair damage such as hair breakage and split ends associated with a perm treatment, improve the feel of hair after the perm treatment, prevent curls from falling over time, and maintain curls formed on hair well for a long period of time, there is known a "hair treatment agent characterized by containing a basic amino acid and hemin or hemin as essential ingredients" (Patent Document 2). However, Patent Document 2 does not describe improving the toughness and / or elasticity of hair, more specifically, restoring hair strength after hair damage.

[0005] Prior art literature Patent Literature Patent Document 1: Japanese Patent Application Laid-Open No. 2021-113179 Patent Document 2: Japanese Patent Application Laid-Open No. 1994-107528 Non-patent literature Non-patent document 1: Journal of the Japanese Society of Fiber Science, General Paper, Vol. 69, No. 7, 2013, p. 132-140, Morphological and physical property changes of hair caused by solvent extraction and boiling water treatment Non-patent document 2: Leprosy, Vol. 26, No. 2, p82-p91, Serological reaction to leprosy (Ogata's slide agglutination reaction method and supplementary test of complement fixation reaction) Summary of the invention

[0006] Technical problem to be solved by the invention The technical problem to be solved by the present invention is to provide a novel preparation etc. which can improve the toughness and / or elasticity of hair, more specifically, restore the strength of hair after hair damage.

[0007] Technical solutions for solving technical problems Therefore, the inventors of the present invention have conducted intensive studies and have newly confirmed that hemin is adsorbed to keratin in hair and that the detached stratum corneum in damaged hair is restored by hemin treatment, thereby completing the present invention.

[0008] The present invention includes the following items.

[0009] [Item 1] A preparation for improving the toughness and / or elasticity of hair, comprising hemin as an active ingredient.

[0010] [Item 2] A composition comprising the preparation described in [Item 1].

[0011] [Item 3] The composition according to [Item 2], further comprising polyethylene glycol having an average added mole number of ethylene oxide of 25 or more.

[0012] [Item 4] The composition according to [Item 2], further comprising polyethylene glycol having an HLB value of 14 or more.

[0013] [Item 5] The composition according to [Item 2], further comprising polyethylene glycol having an average number of added moles of ethylene oxide of 25 or more and an HLB value of 14 or more.

[0014] [Item 6] The composition according to any one of [Item 2] to [Item 5], which is in the form of a composition for external use on the skin.

[0015] Effects of the Invention According to the present invention, a novel agent for improving the toughness and / or elasticity of hair can be provided. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1AThe following is an overview of the torsional stress measurement performed in Experiment 1 of the embodiment and the calculated torsional moment (T) and the second polar moment of cross section I. ρ The torsional stress measurement is to measure the change in torsional moment (T) when the torsion angle (θ / l) per unit length is changed. The torsional stress has T = (G·I ρ ·θ) / l relationship ( Figure 1A ), so the slope of the plot is equivalent to G·I ρ The slope (the arrow in the graph) is defined as the torsional rigidity ( Figure 1B As shown). The second polar moment of the cross section I ρ (Polar moment of inertia of area)is a value calculated by measuring the hair diameter, so the rigidity modulus G (Modulus of rigidity) related to torsional stress can be obtained. Calculate "T" and "I ρ The calculation formula of " Figure 1A A schematic diagram of the hair and the twisting of the hair are also shown in Figure 1A As shown in Figure 1A As shown in the schematic diagram, in Experiment 1, the hair was twisted three times clockwise and then immediately twisted six times counterclockwise.

[0017] Figure 1B A graph is shown in which the vertical axis plots the torsional moment (T) and the horizontal axis plots the torsional angle per unit length (θ / l). The slope of the graph G·I ρ Represents torsional stiffness.

[0018] Figure 2 This is a flow chart showing the steps from the preparation of the sample (hair) used for the torsional stress measurement performed in Experiment 1 of the Example to the measurement.

[0019] Figure 3 The figure shows the spectrum of group 2 of experiment 4. The horizontal axis represents wavelength (nm) and the vertical axis represents absorbance (Abs). DETAILED DESCRIPTION

[0020] Hereinafter, the mode for carrying out the present invention will be described.

[0021] (Hemin) Regarding the hemin (including hematin, for example) contained in the composition containing the preparation of the present invention, for example, in order to exert the desired effect, it is preferably contained at 0.001% or more, more preferably at 0.002% or more, and further preferably at 0.005% or more. In addition, regarding the hemin contained in the reagent of the present invention, for example, in consideration of the desired toxicity, it is preferably contained at 5% or less, more preferably at 1% or less, more preferably at 0.1% or less, and further preferably at 0.05% or less.

[0022] (Improves hair strength and / or elasticity) The toughness of hair is the strength of hair. Strength is the strength of hair that can withstand stretching without breaking. The elasticity of hair is the elasticity of hair (like a spring or rubber, which stretches when stretched and returns to its original length when released).

[0023] (Form of the composition) The composition of the present invention (composition for external use on the skin, etc.) includes: 1) pharmaceuticals in the form of ampoules, capsules, powders, granules, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. in a suitable form for application, such as 1) pharmaceuticals, 2) quasi-pharmaceuticals, 3) topical or systemic external skin preparations (for example, lotions, emulsions, creams, ointments, lotions, oils, basic cosmetics such as facial masks, solid soaps, liquid soaps, facial cleansers such as hand soaps, skin cleansers, massage preparations, cleansing preparations, hair removers, depilatory preparations, shaving preparations, aftershaves, preshaves, shaving creams, foundations, lipsticks, blushers, eye shadows, eyeliners) , mascara and other color cosmetics, perfumes, nail polish, nail polish removers, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations for scalp and hair (for example, shampoo, conditioner, hair care, hair pre-care, permanent perm solution, hair dye, hair styling, hair treatment, hair growth and nourishment, poultices, plasters, tapes, sheets, aerosols, etc.), 5) bath preparations for use in bath water, 6) other anti-armpit odor agents, deodorants, antiperspirants, sanitary products, sanitary napkins, wet wipes, etc.

[0024] (Composition components) Such a composition can be produced by arbitrarily selecting and combining the components and additives listed below as needed within a range that does not impair the effects of the present invention. It should be noted that tranexamic acid and nicotinamide are as described above.

[0025] (1) Various oils and fats Avocado oil, almond oil, anise oil, perilla oil, olive oil, orange oil, orange roughy oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, candlenut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, peach kernel oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, Japan wax, coconut oil, tallow, lard, squalene, squalane, alkane of shark liver oil or hydrides (hardened oils, etc.) of these oils and fats, etc.

[0026] (2) Waxes Beeswax, carnauba wax, cetyl wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, lignite wax, shellac wax, rice bran wax, etc.

[0027] (3) Mineral oils Liquid paraffin, petrolatum, paraffin wax, ozokerite, pure ozokerite, microcrystalline wax, etc.

[0028] (4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12 - hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, and synthetic fatty acids such as isononanoic acid, caproic acid, 2 - ethylbutyric acid, isovaleric acid, 2 - methylvaleric acid, 2 - ethylhexanoic acid, isovaleric acid.

[0029] (5) Alcohols Natural alcohols such as ethanol, isopropanol, lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2 - hexyl decanol, isostearyl alcohol, 2 - octyldodecanol.

[0030] (6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3 - butanediol, pentanediol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol, etc.

[0031] (7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, di - methyl octanoate hexyl decyl ester, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

[0032] (8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.

[0033] (9) Gum, sugar or water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac, Irish moss, karaya gum, tragacanth gum, carob bean gum, quince seed, agar, casein, lactose, fructose, sucrose or its esters, trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan with alkylene (C2-C4) oxide added by ethylene oxide, low molecular weight chitin or chitosan, chitosan salt, chitosan sulfate or chitosan, phosphorylated chitosan cellulose or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or their cross-linked polymers, carboxyvinyl polymers, polyethylene imine, etc.

[0034] (10) Surfactants Anionic surfactants (alkyl carboxylates, alkyl sulfonates, alkyl sulfate ester salts, alkyl phosphate ester salts), cationic surfactants (alkyl amine salts, alkyl quaternary ammonium salts), amphoteric surfactants: carboxylic acid type amphoteric surfactants (amino type, betaine type), sulfate type amphoteric surfactants, sulfonic acid type amphoteric surfactants, phosphate type amphoteric surfactants, nonionic surfactants (ether type nonionic surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants, protein hydrolyzate derivatives, polymer surfactants, titanium and silicon-containing surfactants, fluorinated carbon surfactants), etc.

[0035] (11) Various vitamins Vitamin A family: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B family: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, niacin, pantothenic acid, biotin, choline, inositol, vitamin C family: vitamin C acid or its derivatives, vitamin D family: ergocalciferol (vitamin D2), cholecalciferol Vitamin D3, dihydrotachysterol, vitamin E family: vitamin E or its derivatives, ubiquinones, vitamin K family: phytomenadione (vitamin K1), menaquinone (vitamin K2), 2-menadione (vitamin K3), hydromenaquinone (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin P (rutin, erythritol, hesperidin), vitamin U, etc.

[0036] (12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, and their sulfates, phosphates, nitrates, citrates, or amino acid derivatives such as pyrrolidonecarboxylic acid, etc.

[0037] (13) Additives According to the type and form of the product to be added, conventional processing methods are performed (for example, arbitrarily selecting and combining pulverization, milling, washing, hydrolysis, fermentation, purification, pressing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc.), and various raw materials can be arbitrarily selected and supplied.

[0038] (Polyethylene glycol) In the present invention, polyethylene glycol having a predetermined average number of added moles of ethylene oxide and / or an HLB value of 14 or more may be used.

[0039] The lower limit of the average number of moles of ethylene oxide added is preferably 25 or more, more preferably 26, more preferably 27, more preferably 28, and even more preferably 29 from the viewpoint of desired effects (storage stability, etc.).

[0040] HLB is a value indicating the degree of hydrophilicity or lipophilicity (hydrophobicity) of a surfactant, and refers to the HLB value at 25°C based on Griffin's definition. In the present invention, in order to achieve the desired effect, the upper limit of the HLB value is preferably 20, and the lower limit of the HLB value is preferably 14. Griffin's HLB value is defined in J.Soc.Cosm.Chem., 1954, 5:249-256. In addition, the concepts of the organic value and inorganic value of the oil agent in the organic concept diagram are highly correlated with the concepts of hydrophilicity and lipophilicity in the HLB method. When the value obtained by comparing the ratio of the organic value to the inorganic value: IV / OV=IOB (Inorganic Organic Balance) and the HLB value are compared, the HLB value=IOB value×10 is approximately established.

[0041] The mixed HLB value is the HLB value of a mixture of one or more oils and one or more surfactants when these are used. It is a value obtained by weighted averaging the HLB values ​​of the oils and surfactants based on their content mass ratios, and is calculated using the following formula.

[0042] Mixed HLB value =Σ(10×IOBx×Wx) / ΣWx+Σ(HLBy×Wy) / ΣWy (IOBx represents the IOB value of oil X, Wx represents the mass (g) of oil X, HLBy represents the HLB value of surfactant Y, and Wy represents the mass (g) of surfactant Y.) The present invention is further described in detail with reference to the following examples, but the present invention is not limited by these examples. It should be noted that in the following examples, the unit % representing the amount of each component added refers to mass %.

[0043] Example Hereinafter, examples of the present invention will be described. Experimental materials used in the experiments listed in the examples are as follows.

[0044] (Experiment 1: Torsional stress measurement using human hair) The degree of toughness of hair and the like resulting from the application of the hemin-containing composition (the hemin-containing preparation) to the hair was confirmed by torsional stress measurement.

[0045] The torsional stress measurement was carried out according to the method described in the literature (Journal of Makeup Technology, Vol. 36, No. 4, 2002, pp. 262-272). Figure 1A and Figure 1B An overview of the measurement is described in . Figure 2 The following is a flow chart from the preparation of hair to the measurement.

[0046] 0. Solution for treating hair bundles The solutions (solutions 1 to 3) described in the following Table 1 were prepared.

[0047] [Table 1]

[0048] In the following, Chemical Formula 1 represents the structure of hemin, Chemical Formula 2 represents the structure of chlorophyll iron Na, and Chemical Formula 3 represents the structure of protoporphyrin IX.

[0049] [Chemistry 1]

[0050] [Chemistry 2]

[0051] [Chemistry 3]

[0052] 1. Preparation of Hair for Experimental Use A human hair bundle (hair bundle, Beaulax, 10 cm, 2 g, black hair) was washed with 1% SDS at room temperature (25°C) for 1 hour. The washed hair bundle was washed with tap water. After washing with the tap water, the hair bundle was naturally dried at room temperature.

[0053] 2. Injury treatment 1. Then, immerse (treat) the hair bundle in a 98% formic acid solution at room temperature for 1 hour. Rinse the immersed hair bundle with tap water. After rinsing with the tap water, dry the hair bundle naturally at room temperature. After drying naturally, sample a portion of the hair bundle. Figure 2 of the hair bundle of "Measurement (1)".

[0054] 3. Sample processing The hair bundle treated in 2. is immersed in each of the above solutions 1, 2 and 3 at 40°C for 30 minutes. The immersed hair bundle is washed with tap water. After washing with the tap water, the hair bundle is naturally dried at room temperature. After the natural drying, a part of the hair bundle is sampled. Figure 2 of the hair bundle of "Measurement (2)".

[0055] 4. Determination of torsion and torsional stress of hair bundles The hair bundles of the measurement (1) and the hair bundles of the measurement (2) were subjected to a predetermined twist (twisting three times clockwise and then twisting six times counterclockwise immediately). After the twisting, the torsional stress was measured by comparing the hair bundles of the measurement (2) with the hair bundles of the measurement (1) using the method described in FIG1 . The measurement results (relative values ​​to the hair bundles of the measurement (1)) are described below.

[0056] The group with solution 1 was 1.141, the group with solution 2 was 1.114, and the group with solution 3 was 1.089.

[0057] (Experiment 2: Determination of storage stability) The storage stability (whether or not aggregates are formed) of a solution (composition) containing a hemin-containing solution and a predetermined polyethylene glycol (surfactant) was confirmed.

[0058] 1. Preparation of samples used in the experiment As a solution containing hemin, Growthphyllin P (PF) (Ichimaru Natural Beauty Co., Ltd., composition (93% water, 5% ethanol, 1% hemin (ferrous hemin), 1% phenoxyethanol)) was prepared.

[0059] Then, polyethylene glycol and the like (surfactant) shown in Table 2 below were prepared.

[0060] [Table 2]

[0061] 2. Test methods This test was conducted using the method using a glass slide described in Non-Patent Document 2, etc. Each surfactant shown in Table 2 was mixed with water and dissolved at 70°C. Then, a solution containing hemin (final concentration of 5%) was added. The composition of the composition after the addition is shown in Table 3 below. After the addition, the pH of the composition was adjusted (adjusted to pH 4.0) using lactic acid while stirring. 200 μL of the composition was sandwiched between two glass slides, and the coagulation was visually confirmed.

[0062] Each composition shown in Table 3 was stored (for 30 days) in a desiccator set at 40° C. 200 μL of the stored composition was sandwiched between two glass slides, and aggregates were visually observed.

[0063] 3. Test results The test results (confirmed results) are shown in the following Table 3. The details in Table 3 are as follows.

[0064] · 0 (circle): No condensate (there is no condensate after saving) × (cross): Agglomerates were generated in the stirring stage before storage In Compositions 1 to 6 (compositions in which the HLB value of the surfactant used was 14 or more and the average number of moles of ethylene oxide added was 30 or more), the result was 0.

[0065] [Table 3]

[0066] (Experiment 3: Determination of storage stability) The storage stability (whether or not aggregates are formed) of a solution (composition) containing a hemin-containing solution, a predetermined polyethylene glycol (surfactant), and other components was confirmed.

[0067] 1. Preparation of samples used in the experiment The compositions described in Table 4 (Composition 11 and Comparative Example 1) were prepared. In addition, for the compositions, before adding the hemin-containing solution, a composition mixed with components other than hemin was prepared.

[0068] [Table 4]

[0069] 2. Test methods This test was conducted using the method using a glass slide described in Non-Patent Document 2, etc. The compositions described in Table 4 (Composition 11 and Comparative Example 1) were stored in a desiccator set at 40° C. (30 days). 200 μL of the stored composition was sandwiched between two glass slides, and the aggregates were visually confirmed.

[0070] 3. Test results The test results (confirmed results) are shown in the following Table 4. The details in Table 4 are as follows.

[0071] · 0 (circle): No condensate (there is no condensate after saving) × (cross): Agglomerates were generated in the stirring stage before storage Compared with Comparative Example 1, in Composition 11 (a group in which the HLB value of the surfactant (PEG-60 hydrogenated castor oil) used was 14 or more and the average number of added moles of ethylene oxide was 30 or more), the result was 0.

[0072] (Formula example) Table 5 below shows formulation examples of bath conditioners (conditioners and compositions used in the bathtub and rinsed out after mixing with shampooed hair).

[0073] [Table 5]

[0074] (Experiment 4: Analysis of the interaction between hemin and keratin) We determined whether hemin interacts with keratin, a component of hair. The experimental method was based on the method described in the paper (Biochemical and Biophysical Research Communications, Volume 411, Issue 2, 29 July 2011, Pages 299-304, Iron(III) mesoporphyrinIX and iron(III) deuteroporphyrin IX bind to the Porphyromonas gingivalisHmuY hemophore).

[0075] 1. Specimens and equipment used in the experiment UV2600i: Shimadzu Corporation, UV-visible spectrophotometer (spectral measurement instrument).

[0076] BSA solution: BSA (albumin derived from bovine serum (BSA), crystalline product, product code: 016-15091, Fujifilm Wako Pure Chemical Industries, Ltd.) was dissolved in PBS at a concentration of 10 mM.

[0077] · PQUα liquid: This is a liquid containing PROTICUTE U ALPHA (produced by Ichiraku Natural Beauty, containing α-keratin). It is a solution made by diluting PROTICUTE U ALPHA with PBS to a solid content concentration of 0.1%.

[0078] Solution containing hemin: a solution in which hemin (Tokyo Chemical Industry Co., Ltd., CAS RN: 16009-13-5, product code: H0008, Hemin) is dissolved in DMSO at a concentration of 1 mM.

[0079] 2. Experimental Methods Prepare the samples of Group 1 and Group 2 as shown in Table 6 below. As described in the paper (Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy, Volume 193, 15 March 2018, Pages 23-32, Interactions of hemin with bovineserum albumin and human hemoglobin: A fluorescence quenching study), BSA is known to interact with hemin. Therefore, based on this knowledge, Group 1 was set as a positive control in Experiment 4.

[0080] [Table 6]

[0081] Groups 1 and 2 were allowed to stand at 25° C. for 10 minutes. The spectra of Groups 1 and 2 after the standing were measured using UV2600i. The spectra were scanned in the range of 200 nm to 800 nm using a DMSO / PBS=2 / 100 solution as a reference.

[0082] 3. Experimental Results In Group 1 and Group 2, changes in the spectrum near 500 to 550 nm were confirmed. Figure 3 The spectrum of Group 2 is shown. Figure 3 The arrow portion (500-550 nm) is the portion where the spectrum changes.

[0083] Although the embodiments of the present invention (including examples and formulation examples) have been described above with reference to the drawings, the specific configuration of the present invention is not limited thereto, and even if there are design changes within the scope not departing from the gist of the present invention, they are also included in the present invention.

[0084] Industrial Applicability According to the present invention, the hair styling agent can be used as a novel agent for improving the toughness and / or elasticity of hair.

Claims

1. A preparation for improving the toughness and / or elasticity of hair, characterized in that Contains hemin as an active ingredient.

2. A composition, characterized in that Contains the following (a) and (b): (a) the preparation according to claim 1; (b) Polyethylene glycol having an average added mole number of ethylene oxide of 25 or more.

3. A composition, characterized in that Contains the following (a) and (c): (a) the preparation according to claim 1; (c) Polyethylene glycol having an HLB value of 14 or more.

4. A composition, characterized in that Containing the following (a) and (d): (a) the preparation according to claim 1; (d) Polyethylene glycol having an average number of added moles of ethylene oxide of 25 or more and an HLB value of 14 or more.

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