Capsule containing lutein ester and preparation method thereof

Abstract

The invention discloses a lutein ester-containing capsule and a preparation method thereof, the lutein ester-containing capsule comprises a core liquid and a rubber shell wrapping the core liquid, and the core liquid comprises lutein ester; the glue shell is prepared from the following components in parts by weight: 13 to 20 parts of plant colloid, 5.1 to 10.5 parts of auxiliary agent and 0.1 to 0.4 part of curing agent; the curing agent is selected from water-soluble metal salt. According to the capsule containing the lutein ester, the curing agent is added to be combined with the plant colloid, the temperature-resistant and moisture-resistant effects of the capsule shell are enhanced, the allergy risk possibly caused by animal glue is avoided by selecting the plant colloid, and the range of applicable people is widened.

Description

Technical Field The invention belongs to the technical field of health food preparation, and particularly relates to a capsule containing lutein ester and a preparation method thereof. Background Art

[0002] With the development of science and technology, more and more people use electronic screens for a long time, which leads to eye fatigue and may even cause a series of eye problems. Therefore, eye health problems such as visual fatigue are becoming more and more common in modern society. Lutein esters, as an effective ingredient for preventing eye diseases, have been favored by consumers. As a precursor of lutein, lutein esters are more stable than lutein and can be converted into lutein in the body, which has a positive protective effect on eye health. Lutein can absorb blue light and reduce the damage of blue light to the eyes. It also has antioxidant and anti-inflammatory functions, prevents cataracts and macular degeneration, and protects the retina.

[0003] There are many dosage forms of lutein ester products on the market. Soft capsules, as a common dosage form of health food, are popular because of their convenience, simple use, accurate dosage and appropriate ratio, and raw materials that are not easily oxidized and decomposed. However, traditional soft capsule shells are mostly made of animal glue, which has a certain risk of allergies, and animal glue capsules are easily affected by moisture and cause adhesion, which causes the contents in the capsule to deteriorate or fail, further increasing the production cost. Therefore, it is urgent to prepare a lutein capsule with low consumption risk and easy storage and transportation. Summary of the invention

[0004] In view of the problems that existing lutein ester capsules have allergic risks and are difficult to store and transport, the present invention provides a capsule containing lutein ester and a preparation method thereof.

[0005] The technical solution adopted by the present invention to solve the above technical problems is as follows: In a first aspect, an embodiment of the present invention provides a capsule containing lutein ester, comprising a core liquid and a capsule shell wrapping the core liquid, wherein the core liquid comprises lutein ester; components for preparing the capsule shell comprise 13 to 20 parts of plant colloid, 5.1 to 10.5 parts of auxiliary agent and 0.1 to 0.4 parts of curing agent; the curing agent is selected from water-soluble metal salts.

[0006] Optionally, the plant colloid includes gellan gum, and the mass ratio of the gellan gum to the curing agent is (50~200):1.

[0007] Optionally, the mass proportion of the gellan gum in the plant colloid is 25% to 70%.

[0008] Optionally, the capsule containing lutein ester satisfies at least one of the following conditions: The diameter of the capsule containing lutein ester is 2-8 mm; The mass ratio of the gel shell to the core liquid is (4-9):1; The water content of the capsule shell in the lutein ester capsule is 0.5% to 2%; The compression resistance value of the capsule containing lutein ester is 39.2~78.4N.

[0009] Optionally, the plant colloid also includes at least one of carrageenan, sodium alginate, agar, locust bean gum, xanthan gum, and maltodextrin.

[0010] Optionally, the water-soluble metal salt includes at least one of sodium chloride, potassium chloride, calcium chloride and magnesium chloride.

[0011] Optionally, the auxiliary agent includes 5 to 10 parts of a plasticizer and 0.1 to 0.5 parts of a sweetener.

[0012] Optionally, the plasticizer includes at least one of propylene glycol, glycerol, polyethylene glycol, and sorbitol; And / or, the sweetener includes at least one of sucralose, mogroside, mannitol and xylitol.

[0013] Optionally, the core liquid includes 10 to 40 parts of lutein ester, and also includes at least one of 2 to 8 parts of zeaxanthin, 10 to 40 parts of DHA algae oil, 5 to 10 parts of ARA, 1 to 5 parts of ALA, 1 to 5 parts of blueberry powder, 0.01 to 1 part of lycopene, 0.01 to 1 part of beta-carotene, 20 to 100 parts of sunflower oil and 1 to 5 parts of lemon oil.

[0014] In a second aspect, the present invention further provides a method for preparing a capsule containing lutein ester, comprising the following steps: The plant colloid, the auxiliary agent, the deionized water and the curing agent are mixed according to the weight components, heated and stirred, and kept warm at 80-95° C. to obtain a gel shell liquid for preparing the gel shell; The shell liquid and the core liquid are dripped into the cooling liquid through a coaxial double-layer dripper to obtain a wet pill; The wet pellets are cooled, solidified and shaped, and then deoiled and dried to obtain the capsules containing lutein ester.

[0015] In the present invention, the capsule shell introduces plant colloids to avoid the allergic risk caused by animal glue and expand the scope of applicable population. By adding a curing agent of water-soluble metal salts, the metal cations dissolved in deionized water are combined with the plant colloids to form a gel, thereby enhancing the heat and moisture resistance of the capsule shell, avoiding adhesion caused by moisture during the storage of the capsule, and facilitating the storage and transportation of the capsule. DETAILED DESCRIPTION

[0016] In order to make the technical problems, technical solutions and beneficial effects solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0017] An embodiment of the present invention discloses a capsule containing lutein ester, comprising a core liquid and a capsule shell wrapping the core liquid, wherein the core liquid comprises lutein ester; components for preparing the capsule shell comprise 13 to 20 parts of plant colloid, 5.1 to 10.5 parts of auxiliary agent and 0.1 to 0.4 parts of curing agent; the curing agent is selected from water-soluble metal salts.

[0018] In this embodiment, the capsule shell avoids the allergic risk caused by animal glue by introducing plant colloid, and expands the scope of applicable population. By adding a curing agent of water-soluble metal salts, the metal cations dissolved in deionized water are combined with the plant colloid to form an irreversible gel, which enhances the heat and humidity resistance of the capsule shell, avoids adhesion caused by moisture during storage of the capsule, and facilitates the storage and transportation of the capsule. The weight parts of plant colloid include but are not limited to 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts. The weight parts of auxiliary agents include but are not limited to 5.1 parts, 5.4 parts, 5.8 parts, 6.2 parts, 6.6 parts, 7 parts, 7.4 parts, 7.8 parts, 8.2 parts, 8.6 parts, 9 parts, 9.4 parts, 9.8 parts, 10.2 parts or 10.5 parts. The weight parts of deionized water include but are not limited to 300 parts, 340 parts, 380 parts, 420 parts, 460 parts or 500 parts. The weight parts of curing agent include but are not limited to 0.1 parts, 0.2 parts, 0.3 parts or 0.4 parts. In some embodiments, the plant colloid includes gellan gum, and the mass ratio of the gellan gum to the curing agent is (50-200): 1. The metal cations of the metal salt react with the gellan gum to generate a thermally irreversible gel, thereby enhancing the temperature and humidity resistance of the capsule shell, preventing the capsule from being damp and sticking during storage, and facilitating the storage and transportation of the capsule.

[0019] Specifically, the mass ratio of gellan gum to curing agent includes but is not limited to 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, 110:1, 120:1, 130:1, 140:1, 150:1, 160:1, 170:1, 180:1, 190:1 or 200:1.

[0020] In some embodiments, the mass proportion of the gellan gum in the plant colloid is 25% to 70%. By adjusting the proportion of gellan gum in the plant colloid, the temperature and moisture resistance of the capsule is regulated. Specifically, the mass proportion of gellan gum in the plant colloid includes but is not limited to 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65% or 70%.

[0021] In some embodiments, the capsule containing lutein esters satisfies at least one of the following conditions: The diameter of the capsule containing lutein ester is 2-8 mm; The mass ratio of the gel shell to the core liquid is (4-9):1; The water content of the capsule shell in the lutein ester capsule is 0.5% to 2%; The compression resistance value of the capsule containing lutein ester is 39.2~78.4N.

[0022] By satisfying the above conditions, the capsule is easy to form and the capsule shell has sufficient pressure resistance to prevent the capsule from being deformed and broken under pressure.

[0023] In some embodiments, the plant colloid further comprises at least one of carrageenan, sodium alginate, agar, locust bean gum, xanthan gum, and maltodextrin. The strength and compression resistance of the colloid shell can be regulated by adding other plant gums.

[0024] In some embodiments, the water-soluble metal salt includes at least one of sodium chloride, potassium chloride, calcium chloride, and magnesium chloride. The selection of the above metal salts facilitates the control of the gelling speed and strength of gellan gum.

[0025] In some embodiments, the auxiliary agent includes 5 to 10 parts of plasticizer and 0.1 to 0.5 parts of sweetener. By adding the plasticizer, the strength and compression resistance of the capsule shell are increased, the deformation of the capsule during storage is avoided, and the prepared capsule has a bursting taste. By adding the sweetener, the taste of the capsule is increased, and the sensory enjoyment is improved.

[0026] In some embodiments, the plasticizer includes at least one of propylene glycol, glycerol, polyethylene glycol, and sorbitol. The above plasticizer is selected to increase the flexibility and transparency of the gel formed by the plant colloid, and also to improve the water retention capacity of the gel formed by the plant colloid.

[0027] The sweetener includes at least one of sucralose, mogroside, mannitol and xylitol.

[0028] In some embodiments, the core liquid includes 10 to 40 parts of lutein esters, and also includes at least one of 2 to 8 parts of zeaxanthin, 10 to 40 parts of DHA algae oil, 5 to 10 parts of ARA, 1 to 5 parts of ALA, 1 to 5 parts of blueberry powder, 0.01 to 1 part of lycopene, 0.01 to 1 part of beta-carotene, 20 to 100 parts of sunflower oil and 1 to 5 parts of lemon oil.

[0029] By selecting the core liquid of the above components, the capsule has multiple health benefits. Lutein esters and zeaxanthin are antioxidants, which play an important role in protecting the retina, relieving eye fatigue, and preventing eye diseases. DHA, ALA and ARA are very important in the development of children. They can enhance intelligence, improve human immunity, and promote the development of the brain, retina and tissues and organs throughout the body. Blueberry powder, lycopene, and beta-carotene are not only meaningful in protecting eyesight, but also play a great role in protecting the skin, preventing cardiovascular diseases, and improving immunity. The scientific combination of multiple functional ingredients meets the diverse health needs of consumers.

[0030] In a second aspect, an embodiment of the present invention further provides a method for preparing a capsule containing lutein ester, comprising the following steps: The plant colloid, the auxiliary agent, the deionized water and the curing agent are mixed according to the weight components, heated and stirred, and kept warm at 80-95° C. to obtain a gel shell liquid for preparing the gel shell; The shell liquid and the core liquid are dripped into the cooling liquid through a coaxial double-layer dripper to obtain a wet pill; The wet pellets are cooled, solidified and shaped, and then deoiled and dried to obtain the capsules containing lutein ester.

[0031] Specifically, the preparation process of the shell liquid is as follows: add plasticizer and sweetener according to weight into deionized water at 50-60°C, add plant colloid, heat and stir evenly, raise the temperature to 80-95°C, and then keep warm for 1.5-2.5 hours to obtain the shell liquid for preparing the shell.

[0032] Preparation of core liquid: Mix lutein ester, zeaxanthin, DHA algae oil, ARA, ALA, blueberry powder, lycopene, β-carotene, sunflower oil and lemon oil evenly according to weight parts, heat in a water bath at 35-45°C, and filter with a 100-mesh sieve to obtain the core liquid.

[0033] Preparation of wet pills: The shell liquid and the core liquid are placed in liquid storage tanks for insulation respectively, the rotation speed of the diaphragm pump is set to 25-45 rpm, and the rotation speed of the core liquid pump is set to 20-40 rpm, and the diaphragm pump and the core liquid pump are turned on at the same time, so that the shell liquid and the core liquid are transported through the insulation pipe and dripped into the cooling liquid of 12-18°C through the coaxial double-layer dripper of the pill dropping machine to form wet pills.

[0034] In some embodiments, the wet pellets are cooled in a cold storage at 0-10° C. for 1-2 hours to be cooled, solidified and shaped.

[0035] In some embodiments, the cured wet pellets are allowed to stand for 1-5 minutes to remove oil, and then dried for 3-8 hours at a humidity of 30-60% and a temperature of 15-25° C.

[0036] The present invention is further described below by way of examples.

[0037] Example 1 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention.

[0038] The shell liquid includes 6 parts of carrageenan, 8 parts of gellan gum, 1 part of sodium alginate, 0.1 parts of magnesium chloride, 5 parts of propylene glycol, 0.1 parts of sweetener mogroside, and 400 parts of deionized water.

[0039] The core liquid includes 10 parts of lutein ester, 2 parts of zeaxanthin, 0.02 parts of tomato red, 1 part of blueberry powder, and 18 parts of sunflower oil.

[0040] Preparation of shell liquid Heat deionized water to 60°C, add glycerol, mogroside and magnesium chloride, stir evenly, add the plant colloid mixture evenly, stir evenly, heat to 90°C and keep warm for 1.5 hours to obtain the colloid liquid.

[0041] Preparation of core solution Mix lutein ester, zeaxanthin, tomato red, blueberry powder and sunflower oil evenly, heat in a 45°C water bath to keep warm, and filter through a 100-mesh sieve to obtain the core liquid.

[0042] Preparation of capsules The shell liquid and core liquid are placed in liquid storage tanks for insulation respectively, the rotation speed of the diaphragm pump is set to 5 rpm, the rotation speed of the core liquid pump is set to 40 rpm, and the diaphragm pump and the core liquid pump are turned on at the same time, so that the glue liquid and the core liquid are transported through the insulation pipe and dripped into the cooling liquid at 12° C. through the coaxial double-layer dripper of the pill dropping machine to form wet pills.

[0043] The formed wet pellets were placed in a cold storage at 3°C ​​for 1 hour to cool and solidify. The solidified wet pellets were allowed to stand for 5 minutes to de-oil, and then dried for 6 hours at a humidity of 50% and a temperature of 20°C to obtain capsules.

[0044] Example 2 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: 0.16 parts of magnesium chloride were added.

[0045] Example 3 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: 0.4 parts of magnesium chloride were added.

[0046] Example 4 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Add 20 parts of gellan gum.

[0047] Example 5 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Add 14 parts of carrageenan, 5 parts of gellan gum and 1 part of sodium alginate.

[0048] Example 6 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Add 4 parts of carrageenan, 11.5 parts of gellan gum, 1 part of sodium alginate, and 0.23 parts of magnesium chloride.

[0049] Example 7 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Add 12.6 parts of carrageenan, 3.4 parts of gellan gum and 1 part of sodium alginate.

[0050] Example 8 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Add 1 part of carrageenan, 11 parts of gellan gum, 1 part of sodium alginate, and 0.22 parts of magnesium chloride.

[0051] Example 9 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Replace 6 parts carrageenan with 6 parts agar.

[0052] Example 10 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The shell liquid includes 4 parts of agar, 9 parts of carrageenan, 0.1 parts of magnesium chloride, 5 parts of propylene glycol, 0.1 parts of sweetener mogroside, and 400 parts of deionized water.

[0053] Embodiment 11 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The core liquid includes 10 parts of lutein ester, 20 parts of DHA algae oil and 2 parts of lemon oil.

[0054] Example 12 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The core liquid includes 10 parts of lutein esters, 1 part of zeaxanthin, 40 parts of DHA algae oil, and 2 parts of lemon oil.

[0055] Embodiment 13 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The core liquid includes 10 parts of lutein esters, 1 part of zeaxanthin, 40 parts of DHA algae oil, 10 parts of ARA, 5 parts of ALA, and 2 parts of lemon oil.

[0056] Embodiment 14 This example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The core liquid includes 10 parts of lutein ester, 2 parts of zeaxanthin, 30 parts of DHA algae oil, 5 parts of ARA, 2 parts of ALA, 2 parts of blueberry powder, and 0.02 parts of lycopene.

[0057] Comparative Example 1 This comparative example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The shell fluid does not contain a curing agent.

[0058] Comparative Example 2 This comparative example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The curing agent is 0.6 parts of magnesium chloride. The capsule liquid has eccentricity and deformation problems during the dripping process, causing the capsule to rupture and unable to form.

[0059] Comparative Example 3 This comparative example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: The curing agent is 0.05 parts of magnesium chloride.

[0060] Comparative Example 4 This comparative example is used to illustrate the capsule containing lutein ester and the preparation method thereof disclosed in the present invention, and is different from Example 1 in that: Replace the vegetable colloids with 17 parts of gelatin.

[0061] Performance Testing Moisture and temperature resistance test: 30 capsules were randomly selected from each group of capsules prepared in the embodiments and comparative examples, sealed and placed in a constant temperature and humidity chamber at a temperature of 45°C and a humidity of 75%. The adhesion and oil leakage of the capsules in this environment were recorded for 10 days.

[0062] Moisture content test before and after storage in the capsule shell: 30 capsules were randomly selected from each group of capsules prepared in the examples and comparative examples, and the moisture content of the capsules before and after the moisture and temperature resistance test was measured by a moisture meter, and the average moisture content of the capsules in each group of examples and comparative examples was recorded.

[0063] Compression test: Place the capsule on the pressure platform of the texture analyzer device, and the pressure head descends at a uniform speed toward the pressure sensor. When the pressure head touches the capsule, it continues to descend to apply pressure to the capsule until the capsule breaks. The pressure recorded by the pressure sensor is the pressure value of the capsule.

[0064] The specific test results are shown in Table 1.

[0065] Table 1 From the test results of Examples 1 to 4 and Comparative Examples 1 to 3 in Table 1, it can be seen that the amount of curing agent added and the mass ratio of gellan gum to curing agent have a certain influence on the strength and temperature and moisture resistance of the prepared capsule. When the amount of curing agent added is 0.1 to 0.4 parts and the mass ratio of gellan gum to curing agent is in the range of (50 to 200): 1, the capsule has good temperature and moisture resistance, and the capsule has good compressive strength, thereby avoiding the capsule from breaking during transportation. And from Comparative Examples 1 to 3, it can be seen that when the amount of curing agent added is too low, the strength of the capsule shell liquid is low or does not gel, which reduces the compressive strength of the capsule, so that it is easy to break when absorbing water and producing adhesion in a humid environment, which is not conducive to transportation and storage. When the amount of curing agent added is too high, the capsule shell liquid has eccentricity and deformation problems during the dripping process, causing the capsule to break and be unable to be formed.

[0066] From the test results of Example 1, Example 2, and Example 4 to Example 10, it can be seen that under the premise of a fixed mass ratio of gellan gum to curing agent, the mass proportion of gellan gum in the plant colloid has a certain influence on the strength and temperature and moisture resistance of the prepared capsule. When the mass proportion of gellan gum in the plant colloid is 25% to 70%, the prepared capsule has good pressure resistance and temperature and moisture resistance. When the mass proportion of gellan gum in the plant colloid is not within this range, the gel system formed by gellan gum and other plant colloids in the formed capsule shell liquid changes, and the gel strength of the capsule shell liquid is reduced, thereby affecting the pressure resistance of the capsule.

[0067] From the test results of Examples 11-14, it can be seen that the compositions of different components in the core liquid can cooperate with each other and be embedded in the capsule shell. From the test results of Example 1 and Comparative Example 4, it can be seen that when the plant colloid is replaced with gelatin, although its pressure resistance is much higher than that of Example 1, the water absorption rate of its capsule in a hot and humid environment is much higher than that of this example, and the adhesion is serious, making the capsule easy to break and leak oil.

[0068] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A capsule containing lutein ester, characterized in that: It comprises a core liquid and a capsule shell wrapping the core liquid, wherein the core liquid comprises lutein ester; the capsule shell comprises 13-20 parts of plant colloid, 5.1-10.5 parts of auxiliary agent and 0.1-0.4 parts of curing agent; the curing agent is selected from water-soluble metal salt.

2. The capsule containing lutein ester according to claim 1, characterized in that The plant colloid includes gellan gum, and the mass ratio of the gellan gum to the curing agent is (50~200):

1.

3. The capsule containing lutein ester according to claim 2, characterized in that The mass proportion of the gellan gum in the plant colloid is 25% to 70%.

4. The compression resistance value of the capsule containing lutein ester is 39.2~78.4N.

5. The capsule containing lutein ester according to claim 1, characterized in that The plant colloid also includes at least one of carrageenan, sodium alginate, agar, locust bean gum, xanthan gum and maltodextrin.

6. The capsule containing lutein ester according to claim 1, characterized in that The water-soluble metal salt includes at least one of sodium chloride, potassium chloride, calcium chloride and magnesium chloride.

7. The capsule containing lutein ester according to claim 1, characterized in that The auxiliary agent includes 5 to 10 parts of plasticizer and 0.1 to 0.5 parts of sweetener.

8. And / or, the sweetener includes at least one of sucralose, mogroside, mannitol and xylitol.

9. The capsule containing lutein ester according to claim 1, characterized in that The core liquid includes 10 to 40 parts of lutein ester, and also includes at least one of 2 to 8 parts of zeaxanthin, 10 to 40 parts of DHA algae oil, 5 to 10 parts of ARA, 1 to 5 parts of ALA, 1 to 5 parts of blueberry powder, 0.01 to 1 part of lycopene, 2 to 8 parts of beta-carotene, 20 to 100 parts of sunflower seed oil and 1 to 5 parts of lemon oil.

10. Cooling and solidifying the wet pellets, deoiling and drying are performed to obtain the capsules containing lutein ester.

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