Dialysate regeneration system and dialysis equipment

Abstract

The invention discloses a dialysate regeneration system and dialysis equipment, and the dialysate regeneration system comprises a waste liquid channel, an input end of which receives dialysis waste liquid; the reactor is arranged in the waste liquid passage and is used for decomposing toxins in the dialysis waste liquid; the reactor comprises a cavity, which is provided with an inlet for the dialysis waste liquid to flow in and an outlet for the reaction liquid to flow out; a membrane having a first side and a second side disposed within the cavity, an enzyme being disposed on the first side or the second side of the membrane; wherein the side, provided with the enzyme, of the membrane is communicated with the inlet, the other side of the membrane is communicated with the outlet, dialysis waste liquid flowing in from the inlet is in full contact with the enzyme and then strides across the membrane to flow to the outlet, and the enzyme is intercepted by the membrane on the side where the enzyme is located; and the regenerated liquid pipeline is communicated with the outlet and is used for receiving the reaction liquid subjected to the reaction treatment of the reactor.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and more specifically to a dialysate regeneration system and a dialysis device used in the dialysis field. Background Art

[0002] The Sorbent Dialysis system was first developed by NASA for the recycling of astronauts' urine. In 1973, the first commercial model, the REDY Machine (Regeneration of dialysate), achieved great commercial success. Between 1973 and 1994, the REDY system successfully implemented 6 million hemodialysis treatments, most of which were performed at home, proving its good convenience, safety and clinical value.

[0003] Regenerative dialysis equipment represented by the REDY system can restore used dialysis waste liquid for reuse. Specifically, after the dialysis waste liquid passes through a specially designed adsorption column, it can be converted into a regeneration liquid that meets the standards after component replenishment and reused for dialysis treatment. The adsorption column basically consists of five layers, and the dialysis waste liquid passes through each layer in the adsorption column from top to bottom in a perfusion push manner.

[0004] The adsorption column includes a urea degradation layer, in which enzymes are filled to decompose urea in the dialysis waste liquid. However, under this adsorption column structure, since the dialysis waste liquid passes through the urea degradation layer in a perfusion push manner, on the one hand, the contact between urea and the enzyme is insufficient. On the other hand, there will be a concentration gradient in the urea content in the dialysis waste liquid, and the working efficiency of the enzymes at different positions in the urea degradation layer will vary greatly. For example, the enzyme at the most upstream contacts the highest concentration of urea and exhibits a higher activity, while the enzyme at the downstream does not contact a sufficient concentration of urea and suffers from a serious loss of activity.

[0005] There are some schemes in the related art that separate the layers in the adsorption column to form independent warehouses, and each independent warehouse is connected in series to complete the cleaning of the dialysate. In the warehouse at the stage of removing urea, multiple hollow fibers are included, and urease needs to be solidified on the outside of the hollow fiber. The dialysis waste flows into the hollow fiber from one end of the hollow fiber and flows out through the other end. In this process, urea and the like react with the solidified urease by diffusion. In this way, the flow direction of the dialysate is to flow along the inner cavity of the hollow fiber, and urease is solidified outside the inner cavity. On the one hand, insufficient urea diffusion will cause insufficient cleaning, and on the other hand, the solidified urease will still have the problem of enzymes in different positions similar to the adsorption column not being able to contact urea of ​​sufficient concentration and causing serious loss of activity.

[0006] However, enzymes account for a high proportion of the cost of consumables. Therefore, excessive or insufficient utilization will lead to a significant increase in consumable costs, greatly limiting the commercial application of dialysate regeneration dialysis equipment and the promotion of home dialysis. Summary of the invention

[0007] In view of the shortcomings of the above-mentioned related technologies, the purpose of the present application is to provide a dialysate regeneration system and a dialysis device to overcome the technical problem of low enzyme utilization efficiency under the dialysis column structure existing in the above-mentioned related technologies, resulting in increased costs.

[0008] To achieve the above-mentioned purpose and other related purposes, the first aspect of the present application provides a dialysate regeneration system, comprising: a waste liquid passage, whose input end receives dialysate waste; a reactor, arranged in the waste liquid passage, for decomposing toxins in the dialysate waste; the reactor comprises: a cavity, having an inlet for the dialysate waste to flow in and an outlet for the reaction liquid to flow out; a membrane having a first side and a second side, arranged in the cavity, and an enzyme is configured on the first side or the second side of the membrane; wherein the side of the membrane configured with the enzyme is connected to the inlet, and the other side is connected to the outlet, and the dialysate waste flowing in from the inlet is fully in contact with the enzyme and then flows across the membrane to the outlet, and the enzyme is retained by the membrane on the side where the enzyme is located; a regeneration liquid pipeline, connected to the outlet for receiving the reaction liquid after being treated by the reactor reaction.

[0009] The second aspect of the present application provides a peritoneal dialysis device, comprising: a dialysate regeneration system as disclosed in the first aspect of the present application; a peritoneal dialysis circuit, one end of which is connected to the human peritoneal cavity, and the other end of which is connected to the dialysate regeneration system; a driving device, disposed on the peritoneal dialysis circuit, for driving fluid to flow periodically or continuously in the peritoneal dialysis circuit; and a control device, for executing a treatment mode to periodically or continuously exchange fluid in the human peritoneum.

[0010] The third aspect disclosed in the present application discloses a hemodialysis device, comprising: a dialysate regeneration system as disclosed in the first aspect of the present application; a purification circuit, comprising a first circuit whose input end is connected to a first part of a human body, and a second circuit whose output end is connected to a second part of a human body; a dialysis device, arranged on the purification circuit, for purifying a fluid flowing in the purification circuit, the dialysis device comprising: a dialysate output end connected to an input end of a waste fluid passage of the dialysate regeneration system; and a dialysate input end connected to an output end of a regeneration fluid pipeline of the dialysate regeneration system; a driving device, arranged on the first circuit and located in the purification circuit, for driving a fluid to flow in the purification circuit; and a control device, for executing a treatment mode to purify the fluid flowing in the purification circuit and then input it into the human body.

[0011] In summary, the present application discloses a dialysate regeneration system and a dialysis device, in which an enzyme is arranged on one side of a membrane in a reactor, and the dialysis waste liquid flows in from the inlet on the side of the membrane where the enzyme is arranged, and reacts with the enzyme located on the first side. The reaction liquid after the reaction crosses the membrane under pressure and flows out from the outlet arranged on the other side of the membrane, while the enzyme is retained by the membrane on the side where the enzyme is located. In this way, the reactor of the present application can make the dialysis waste liquid fully contact and react with the enzyme on the side where the enzyme is located, thereby improving the efficiency of enzyme use, reducing the cost of consumables, and avoiding the phenomenon of insufficient toxin removal / decomposition. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] The specific features of the present application are shown in the attached claims. The features and advantages of the invention involved in the present application can be better understood by referring to the exemplary embodiments and drawings described in detail below. The drawings are briefly described as follows:

[0013] Figure 1 Shown is a schematic diagram of the principle of a dialysate regeneration system in one embodiment of the present application.

[0014] Figure 2 Shown is a schematic diagram of the principle of a dialysate regeneration system in another embodiment of the present application.

[0015] Figure 3 Shown is a schematic cross-sectional view of a reactor having a flat-plate membrane in one embodiment of the present application.

[0016] Figure 4 Shown is a schematic cross-sectional view of a reactor having a hollow fiber membrane in one embodiment of the present application.

[0017] Figure 5 Shown is a schematic cross-sectional view of a reactor having a flat-plate membrane in another embodiment of the present application.

[0018] Figure 6 Shown is a schematic cross-sectional view of a reactor having a hollow fiber membrane in another embodiment of the present application.

[0019] Figure 7a Shown is a schematic diagram of the principle of a dialysate regeneration system including a first adsorption device in one embodiment of the present application.

[0020] Figure 7b Shown is a schematic diagram of the principle of a dialysate regeneration system including a second adsorption device in one embodiment of the present application.

[0021] Figure 7c Shown is a schematic diagram of the principle of a dialysate regeneration system including first and second adsorption devices in one embodiment of the present application.

[0022] Figure 8Shown is a schematic diagram of the principle of a dialysate regeneration system in yet another embodiment of the present application.

[0023] Fig. 9 Shown is a schematic diagram of the principle of a peritoneal dialysis device in one embodiment of the present application.

[0024] Figures 10a to 10c Shown are schematic diagrams of dual-channel peritoneal dialysis catheters in different embodiments of the present application.

[0025] Fig.11 Shown is a schematic diagram of the principle of a hemodialysis device in one embodiment of the present application.

[0026] Fig.12 A schematic diagram showing the hemodialysis device of the present application in the pre-dilution mode.

[0027] Fig.13 A schematic diagram showing the hemodialysis device of the present application in post-dilution mode.

[0028] Fig.14 Shown is a schematic diagram of the HDF treatment mode in one embodiment of the hemodialysis device of the present application.

[0029] Fig.15 Shown is a schematic diagram of the HDF treatment mode of the hemodialysis device of the present application in another embodiment. DETAILED DESCRIPTION

[0030] The following specific embodiments are used to illustrate the embodiments of the present application, and those familiar with the technology can easily understand the advantages of the present application and the technical effects that can be achieved by the content disclosed in this specification. In the following description, some embodiments can refer to the accompanying drawings. It should be understood that other embodiments without drawing drawings can also be used, and specific structures, parts or mechanisms, components and operational changes can be made without departing from the spirit and scope of the present application. The following detailed description should not be considered restrictive, and the scope of the embodiments of the present application is limited only by the claims published in the present application. The terms used here are only for describing specific embodiments and are not intended to limit the present application.

[0031] It should be understood that, although in some embodiments the term first, second or third etc. can be used to describe various elements or parameters in this article, these elements or parameters should not be limited by these terms. These terms are only used to distinguish an element or parameter from another element or parameter, and are not used to define the order, priority or importance of multiple elements. For example, the first side can be referred to as the second side, and similarly, the second side can be referred to as the first side, without departing from the scope of the various described embodiments, the first side and the second side are both on one side of the description film, but unless the context is otherwise clearly indicated, they are not the same side. Similar situations also include the first circuit and the second circuit, or the first part and the second part.

[0032] Furthermore, as used in this article, the singular forms "one", "an" and "the" are intended to also include plural forms, unless there is an indication to the contrary in the context. It should be further understood that the terms "comprising", "including" indicate the presence of the described features, steps, operations, elements, components, projects, kinds, and / or groups, but do not exclude the presence, occurrence or addition of one or more other features, steps, operations, elements, components, projects, kinds, and / or groups. For example, the process, method, system, product or equipment comprising a series of steps or units need not be limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or equipment. In addition, the term "and / or" that may be used hereinafter, describes the association relationship of associated objects, indicating that three kinds of relationships may exist, for example, A and / or B, which can represent: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / ", if not otherwise specified, generally represents that the associated objects before and after are a kind of "and / or" relationship. In addition, in the description of the embodiments of the present application, "multiple" refers to two or more than two. Furthermore, the terms "or" and "and / or" used in this document are interpreted as inclusive, or mean any one or any combination. Exceptions to this definition will only occur when a combination of elements, functions, steps or operations are inherently mutually exclusive in some way.

[0033] Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as those commonly understood by ordinary technicians in the field to which this application belongs. It will also be understood that the terms used herein should be interpreted as having the meaning consistent with their meaning in the context of this specification and the relevant field, and should not be interpreted in an idealized or overly formal sense unless explicitly defined in this article.

[0034] As used herein, the terms "treat," "treatment," and "treating," and variations thereof, refer to any reduction in the extent, frequency, or severity of one or more symptoms or symptoms associated with a disorder.

[0035] The term "arterial blood line" refers to the fluid line in the extracorporeal flow circuit that delivers blood from the patient to the dialyzer. The term "venous blood line" refers to the fluid line in the extracorporeal flow circuit that delivers blood from the dialyzer to the patient.

[0036] The term "dialysis" is a type of filtration, or the process of selective diffusion through a membrane. Dialysis removes solutes of a specific range of molecular weight from a fluid to be dialyzed into a dialysate via diffusion through a membrane. During dialysis, the fluid to be dialyzed passes through a filter membrane, while the dialysate passes through the other side of the membrane. Dissolved solutes are transported through the filter membrane by diffusion between the fluids. The dialysate is used to remove solutes from the fluid to be dialyzed. The dialysate can also provide enrichment for other fluids.

[0037] The term "dialyser" refers to a cartridge or container having two flow paths separated by a semipermeable membrane. One flow path is for blood and one flow path is for dialysate. The membrane may be in the form of a hollow fiber, a flat sheet, or a spirally wound form or other conventional forms known to those skilled in the art. The membrane may be selected from the following materials: polysulfone, polyethersulfone, poly(methyl methacrylate), modified cellulose or other materials known to those skilled in the art.

[0038] Relative terms such as "below" or "above" or "upper" or "lower" or "horizontal" or "vertical" may be used herein to describe the relationship of one element, layer or region to another element, layer or region as illustrated in the figure. It will be understood that these terms are intended to cover different device orientations other than the orientation depicted in the figure. In this application, the "vertical", "horizontal" and "parallel" are defined as: including the situation of ±10% on the basis of the standard definition. For example, vertical usually refers to an angle of 90° relative to a reference line, but in this application, vertical refers to the situation within 80° to 100°. Unless otherwise explicitly stated, comparative quantitative terms (such as "above" and "below") are intended to cover the concept of equality. As an example, "above" can not only mean "greater than" in a mathematical sense, but also "equal to".

[0039] In addition, the use of endpoints to limit the range of values ​​herein includes all values ​​contained in the range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, 5, etc.). Unless otherwise indicated, all numerical values ​​used to indicate the number of components, molecular weight, etc. in the specification and claims should be understood to be modified by the term "about" in all cases. Accordingly, unless otherwise indicated, the numerical parameters listed in this specification and claims are approximate values, which may vary depending on the desired properties that the present invention attempts to obtain. Each numerical parameter should be constructed at least according to the number of significant figures stated and by applying general rounding techniques, but this does not limit the basic principle that the scope of the claims is equivalent.

[0040] Although the numerical ranges and parameters setting forth the overall scope of the invention are approximations, the numerical values ​​set forth in the specific examples are provided as precisely as possible. However, all numerical values ​​necessarily include a certain range resulting from the standard deviation of their respective testing measurements.

[0041] The terms used herein are only for the purpose of describing specific embodiments and are not intended to limit the present application. When used herein, the singular forms "a", "an", and "the" are intended to also include the plural forms unless the context clearly indicates otherwise. It will also be understood that when used herein, the terms "comprise", "include", "include" and / or "comprising" specify the presence of stated features, integers, steps, operations, elements and / or parts, but do not exclude the presence or increase of one or more other features, integers, steps, operations, elements, parts and / or combinations thereof.

[0042] The present application is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. The technical solutions in the embodiments of the present application are clearly and completely described. Obviously, the described embodiments are only embodiments of a part of the present application, not all embodiments. Based on the embodiments in the present application, all other embodiments and technical effects obtained by ordinary technicians in this field without making creative work should belong to the scope of protection of this application. "An implementation method", "implementation method" or similar words mentioned in the whole text of this specification mean that the specific features, structures or characteristics described together with the implementation method are included in at least one implementation method of the present application. Therefore, in the whole text of this specification, the appearance of the phrases "in one implementation method", "in an implementation method" and similar words may (but not necessarily) relate to the same implementation method.

[0043] The present application discloses a dialysate regeneration system, which is used to process dialysate waste generated during a dialysis process to generate regeneration fluid, which is then input into a dialysis device or a human body.

[0044] In one embodiment, the dialysate regeneration system can be applied to medical equipment, including but not limited to blood purification equipment, extracorporeal circulation removal system, extracorporeal enrichment and removal equipment, hemodialysis equipment, plasma exchange equipment, extracorporeal peritoneal dialysis equipment, or extracorporeal membrane oxygenation equipment. Among them, the blood purification equipment includes but is not limited to hemodialysis (HD), hemofiltration (HF), hemodiafiltration (HDF), hemoperfusion (HP), blood exchange (PE), immunoadsorption (IA) and continuous blood purification (CRRT), peritoneal dialysis (PD) and other equipment.

[0045] In the embodiments of the present application, the "regeneration fluid" refers to the dialysis waste liquid regeneration fluid formed after the dialysis waste liquid is exchanged with blood or peritoneal fluid and some or most of the toxins or toxic molecules are removed, referred to as the regeneration fluid. Further, the "regeneration fluid" can also be the dialysis waste liquid regeneration fluid formed after the dialysis waste liquid is removed some or most of the toxins or toxic molecules and supplemented with beneficial or necessary molecules such as potassium, calcium and magnesium, referred to as the regeneration fluid. The regeneration fluid can be regarded as fresh dialysis fluid, which is exchanged with blood or peritoneal fluid again, and the cycle is repeated to continuously remove toxins in the blood or peritoneal fluid to achieve the purpose of treatment. The dialysis equipment using this dialysis fluid regeneration mode is called a dialysis fluid regeneration type dialysis machine, which includes a dialysis fluid regeneration type hemodialysis machine and a dialysis fluid regeneration type peritoneal dialysis machine. The biggest advantage of this dialysis machine is that it does not require a water source and a water treatment system, so it is very small and portable, suitable for home hemodialysis and wearable dialysis equipment.

[0046] In some embodiments, the dialysate regeneration system provided in the present application includes a waste liquid passage, a reactor, and a regeneration liquid pipeline. In the following embodiments, the dialysate regeneration system is mainly applied to a peritoneal dialysis (PD) device as an example for illustrative description.

[0047] See also Figure 1 , which is a schematic diagram of the principle of the dialysate regeneration system in one embodiment of the present application, as shown in the figure, the dialysate regeneration system includes a waste liquid passage L2-1, a regeneration liquid pipeline L2-2, and a reactor 1 disposed in the waste liquid passage L2-1. The input end a1 of the waste liquid passage L2-1 receives the dialysis waste liquid, the output end of the waste liquid passage L2-1 is connected to the reactor 1 to input the dialysis waste liquid into the reactor 1, the reactor 1 decomposes the toxins in the input dialysis waste liquid, and the reaction liquid after the reaction treatment in the reactor 1 flows into the input end of the regeneration liquid pipeline L2-2, and the regeneration liquid obtained by the dialysate regeneration system after the reaction liquid is treated is output through the output end a2 of the regeneration liquid pipeline L2-2.

[0048] The input end of the waste liquid passage can be directly connected to a waste liquid container for storing dialysis waste liquid, or it can be connected to the outlet of the dialysis waste liquid of the peritoneal dialysis (PD) device, or it can be connected to the outlet of the dialysis waste liquid of the hemodialysis (HD) device. It should be noted that the present application does not limit the specific connection position and connection form of the input end of the waste liquid passage, and it is only necessary to meet the input end of the waste liquid passage to receive the dialysis waste liquid. In one example, the dialysate regeneration system is applied to a peritoneal dialysis device, and the input end of the waste liquid passage is connected to a channel for outputting the dialysis fluid in the peritoneal dialysis circuit of the peritoneal dialysis device, so as to receive the dialysis waste liquid output by the peritoneal dialysis circuit. In another example, the dialysate regeneration system is applied to a hemodialysis device, and the input end of the waste liquid passage is connected to the dialysate output end of the dialysis device in the hemodialysis device, so as to receive the dialysis waste liquid output by the dialysis device.

[0049] In one embodiment, see Figure 2 , which is a schematic diagram of the principle of a dialysate regeneration system in another embodiment of the present application, as shown in the figure, a dialysate pump 20 is provided on the waste liquid passage, and the dialysate pump 20 is used to drive the fluid in the waste liquid passage L2-1 to flow forward or reversely. Specifically, the dialysate pump 20 is used to provide power to the dialysate waste in the waste liquid passage L2-1, so that the dialysate waste flows in a preset flow direction (forward or reverse). The dialysate pump 20 is exemplified by a peristaltic pump, a pneumatic diaphragm pump, or a pressure pump.

[0050] In another embodiment, a first dialysate pump is provided on the waste liquid passage, and a second dialysate pump is provided on the regeneration liquid pipeline. The dialysate regeneration system changes the total amount of liquid equilibrium state of the dialysate regeneration system by the differential speed of the first dialysate pump and the second dialysate pump. Specifically, the speed of the second dialysate pump is different from that of the first dialysate pump to increase or decrease the total amount of liquid equilibrium state of the dialysate regeneration system to achieve controllable and measurable ultrafiltration or filtration. Wherein, when periodically filtering the dialysis waste liquid, the difference in the rotation speeds of the two pumps is often periodic, or dynamically adjusted with the filtration amount or pressure.

[0051] In one embodiment, the flow rate of the fluid in the waste liquid passage is the same as the flow rate of the fluid in the regeneration liquid pipeline. In one example, the flow rate of the fluid in the waste liquid passage and the flow rate of the fluid in the regeneration liquid pipeline are both 50 mL / min-300 mL / min. For example, the flow rate of the fluid on the waste liquid passage and the flow rate of the fluid in the regeneration liquid pipeline are 50mL / min, 60mL / min, 70mL / min, 80mL / min, 90mL / min, 100mL / min, 110mL / min, 120mL / min, 130mL / min, 140mL / min, 150mL / min, 160mL / min, 170mL / min, 180mL / min, 190mL / min, 200mL / min, 210mL / min, 220mL / min, 230mL / min, 240mL / min, 250mL / min, 260mL / min, 270mL / min, 280mL / min, 290mL / min, or 300mL / min.

[0052] In one embodiment, if Figure 2 As shown, the waste liquid passage L2-1 is provided with a pre-liquid bypass L2-3, and the pre-liquid bypass L2-3 is used to pre-fill, empty, or flush the passage of the dialysate regeneration system. In this embodiment, the waste liquid passage L2-1 is provided with a short-circuit valve 21' connected in parallel with the pre-liquid bypass L2-3.

[0053] In one embodiment, the pre-liquid bypass L2-3 is a system for pre-filling and emptying the purification circuit, which is connected to a liquid storage container (e.g., Figure 2 The prefabricated liquid bag 30 shown is, for example, a liquid bag made of medical plastic), and cooperates with the dialysate pump 20 as a mode, or the liquid storage container is placed upright or inverted to achieve the two operations of pre-filling and emptying, that is, in the pre-filling mode, the outlet of the liquid in the liquid storage container is at a low position; and in the emptying mode, the outlet of the gas in the liquid storage container is at a high position; compared with the conventional operation in the prior art, the system of the present application has a simple structure, convenient operation, and low learning cost. The operator does not need to repeatedly invert the reactor for continuous circulation pre-filling. Furthermore, the application of the system of the present application enables more scientific treatment of medical waste such as pipelines and waste liquids after emptying.

[0054] In this embodiment, the system for pre-filling and emptying the purification circuit includes a liquid storage container (i.e. Figure 2 The prefabricated liquid bag 30 shown in FIG. 1 ), the circulation loop (i.e. Figure 2The dialysate inlet valve 22 and the regeneration liquid outlet valve 23 are closed and the short-circuit valve 21 is opened to form a circulation loop), and a dialysate pump 20. The liquid storage container is used to store the pre-filled liquid and recover the emptied waste liquid, including a container body, and a first interface and a second interface provided on the container body for serving as an inlet and outlet of liquid or / and gas; the first interface or the second interface is an inlet and outlet of the fluid in the container body. For example, the first interface and the second interface are Figure 2 The prefabricated liquid bag 30 shown in FIG. 1 has a first interface b1 and a second interface b2.

[0055] In this embodiment, the liquid storage container can be switched between upright and inverted states, that is, the state of placing the liquid storage container upright is upright, and the state of placing the liquid storage container upside down is inverted. In order to switch between the two states more simply, a mechanism for placing the liquid storage container upright or inverted is also included. In one embodiment, the mechanism is, for example, a plate or a frame for placing the liquid storage container, and a structure for fixing the liquid storage container and a positioning structure for positioning the upright state and the inverted state are provided on the plate or the frame, so that the liquid storage container can be stabilized in the upright state when it is placed upright, or can be stabilized in the inverted state when it is inverted.

[0056] In this embodiment, the system of the liquid storage container in the pre-filling and emptying purification circuit has two working modes, that is, in the pre-filling mode, the outlet of the liquid in the liquid storage container is at a low position; in the emptying mode, the outlet of the gas in the liquid storage container is at a high position; for example, in the pre-filling mode, the second interface is at a lower height so that the pre-filled liquid in the liquid storage container preferentially enters the pipeline in the circulation loop from the second interface, while in the emptying mode, the first interface is at a higher height so that the gas / bubble in the liquid storage container preferentially enters the pipeline in the circulation loop from the first interface. In the present application, the switching between the pre-filling mode and the emptying mode can be achieved by adjusting the flow direction of the fluid and / or switching the liquid storage container to be upright or inverted.

[0057] In some embodiments, the pre-liquid bypass is, for example, a system for pre-filling and emptying a purification circuit as described in patent document CN2022108507945; in the present application, the full text of patent document CN2022108507945 is cited herein.

[0058] In an embodiment of the present application, the reactor 1 disposed in the waste liquid passage L2-1 includes a cavity, a membrane having a first side and a second side, and an enzyme disposed on the first side or the second side of the membrane. The cavity has an inlet for the dialysis waste liquid to flow in and an outlet for the reaction liquid to flow out, a membrane is arranged in the cavity, an enzyme is disposed on the first side or the second side of the membrane, one side of the membrane where the enzyme is disposed is connected to the inlet for the dialysis waste liquid to flow in, and the other side is connected to the outlet for the reaction liquid to flow out, and the reaction liquid formed after the dialysis waste liquid flowing in from the inlet fully contacts with the enzyme flows across the membrane to the outlet under the pressure provided by the dialysis liquid pump, and the enzyme is retained by the membrane on the side where the enzyme is located.

[0059] In one embodiment, the membrane can be a membrane of different geometric shapes. In one example, the membrane includes one or more of a tubular membrane, a rolled membrane, a flat membrane, and a hollow fiber membrane. Among them, the membrane pore size of the membrane needs to satisfy that the enzyme can be retained on one side of the membrane and the liquid can be filtered to the other side, for example, the membrane pore size is smaller than the size of the enzyme-loaded microspheres, enzyme-loaded microparticles, or enzyme-loaded microcapsules described later. It should be noted that in the embodiment where the membrane is a planar membrane, the first side and the second side are the opposite sides of the flat membrane barrier of the planar structure; for example, in the embodiment where the membrane is a hollow fiber membrane, the first side is the outer side of each hollow fiber membrane tube wall, and the second side is the inner side of each hollow fiber membrane tube wall.

[0060] In one embodiment, the enzyme is used to decompose toxins in the dialysis waste liquid. The decomposition described in the embodiment of the present application refers to catalytic decomposition or synthesis of toxins to achieve the purpose of removing toxins in the dialysis waste liquid, and should not be simply understood as catalytic decomposition. According to the different toxins that the reactor needs to decompose, the type of enzyme is also different. As long as there is an enzyme with corresponding catalytic decomposition function or synthesis function, the concentration of any toxin in the dialysis waste liquid can be changed to achieve the purpose of removing toxins in the dialysis waste liquid. For example, the reactor is used to decompose urea in the dialysis waste liquid, and the corresponding enzyme is configured as urease. For another example, the reactor is used to decompose ethanol in the dialysis waste liquid, and the corresponding enzyme is configured as ethanol oxidase that can oxidize ethanol. For another example, the reactor is used to decompose uric acid in the dialysis waste liquid, and the corresponding enzyme is configured as urate oxidase that can oxidize uric acid. For another example, the reactor is used to decompose phenylalanine in the dialysis waste liquid, and the corresponding enzyme is configured as phenylalanine ammonia lyase that can decompose phenylalanine. It should be noted that the enzyme configured on the first side or the second side of the membrane can be one enzyme or multiple enzymes.

[0061] In one embodiment, the enzyme is formulated in a free state. Compared with the enzyme in the fixed state, the enzyme in the free state can make the concentration of toxins in the dialysis waste liquid that the enzyme contacts similar, further solving the problem of serious activity loss caused by enzymes in different positions not contacting dialysis waste liquid of sufficient concentration.

[0062] In one embodiment, the enzyme may be carried in the form of an enzyme preparation or enzyme-loaded microspheres. The enzyme-loaded microspheres are microspheres immobilized with enzymes, for example, urease microspheres are microspheres immobilized with urease. The enzyme preparation refers to a preparation containing an enzyme. In another embodiment, the enzyme may also be carried in the form of enzyme-loaded microparticles or enzyme-loaded microcapsules. For example, urease microparticles are microparticles immobilized with urease, and urease microcapsules are microcapsules immobilized with urease. When the enzyme carried in the form of the enzyme-loaded microspheres, enzyme-loaded microparticles, enzyme-loaded microcapsules, or enzyme preparations is in a free state on its carrier, the enzyme is considered to be in a free state. Of course, in other embodiments, the enzyme may also exist alone in a free state without being attached to a carrier. The present application does not limit whether the enzyme needs to be carried by a carrier, as long as it is guaranteed that it can be free on the side where it is located.

[0063] In an embodiment of the present application, the inlet of the dialysate is connected to the side of the membrane where the enzyme is configured, and the outlet of the reaction liquid is connected to the other side of the membrane (the side where the enzyme is not configured). Under this structure, after the dialysate flows in from the inlet, the reaction liquid after reacting with the enzyme needs to be pushed by pressure to cross the membrane before it can flow out through the outlet on the other side. This further allows the dialysate to directly contact the enzyme after entering the side of the reactor where the enzyme is located in the present application instead of only part of the substance contacting the enzyme through diffusion. In this way, before crossing the membrane, the dialysate is in continuous contact with the enzyme for a long time by directly impacting the enzyme, which can avoid the inability to remove / decompose some toxins due to the lack of contact with the enzyme or the short contact time. The phenomenon of sufficient production occurs; and the reaction liquid of the present application is directly discharged from the outlet on the other side after crossing the membrane, without the need to be discharged from the outlet on the same side as the inlet through a reciprocating membrane method, and does not need to be contacted with the enzyme through a circulating flow, thereby improving the efficiency of toxin removal / decomposition; further, the enzyme in the reactor is formulated in a free state, which can make the concentration of toxins in the dialysis waste liquid contacted by the enzyme similar, solving the problem of serious activity loss caused by enzymes at different positions not being able to contact dialysis waste liquid of sufficient concentration; the membrane of the present application is trapped on the side where the enzyme is located, which can enable the enzyme to continuously and efficiently decompose toxins on the first side, so as to avoid the problem of low toxin decomposition efficiency caused by a reduction in the number of enzymes.

[0064] In some embodiments, the enzyme in the reactor can be configured on the first side of the membrane or on the second side of the membrane, and correspondingly, the inlet and outlet of the cavity of the reactor are arranged corresponding to the position where the enzyme is located. In the following embodiments, the structure and working principle of the reactor are described in detail with the membrane being a flat membrane and a hollow fiber membrane.

[0065] In some embodiments, when the enzyme is disposed on the first side, the first side is connected to the inlet, and the second side is connected to the outlet. When the dialysis waste fluid flowing from the inlet fully contacts the enzyme on the first side and crosses the membrane to enter the second side, the enzyme is retained on the first side. Figure 3 , which is a cross-sectional schematic diagram of a reactor with a flat membrane in one embodiment of the present application. As shown in the figure, the membrane 11 is a flat membrane. The membrane 11 of the reactor 1 has a first side 102 and a second side 103. The enzyme 12 is arranged on the first side 102. The first side 102 is connected to the inlet 100 of the chamber 10. The dialysis waste flows from the inlet 100 into the first side 102 and fully contacts the enzyme 12. The reaction liquid crosses the membrane 11 under the pressure provided by the dialysate pump in the direction indicated by the dotted arrow, for example, and is discharged from the outlet 101 of the second side 103. The enzyme 12 is retained on the first side 102. In another example, please refer to Figure 4 , showing a cross-sectional schematic diagram of a reactor having a hollow fiber membrane in one embodiment of the present application. As shown in the figure, a plurality of membranes 11 are arranged in the cavity 10 of the reactor 1, and the membrane 11 is a hollow fiber membrane. The hollow fiber membrane has an inner side and an outer side. The outer side of the membrane 11 is a first side 102, and the inner side of the membrane 11 is a second side 103. The enzyme 12 is arranged on the first side 102. The first sides 102 of each membrane 11 are interconnected and connected to the inlet 100 of the cavity 10. After the dialysate flows in from the inlet 100, it fills the first sides 102 of the plurality of membranes 11 and is in full contact with the enzyme 12. After the reaction is completed, the reaction liquid crosses the membrane 11 in a direction indicated by, for example, a dotted arrow under the pressure provided by the dialysate pump, and then flows from the port on the side of the membrane 11 close to the outlet 101 to the outlet 101, and the enzyme 12 is retained on the first side 102. It should be noted that in Figure 4 In the illustrated embodiment, one end of the second side 103 (inner side) of the membrane 11 close to the inlet 100 is closed to prevent the dialysate waste from flowing into the second side 103 from this end, and one end of the second side 103 (inner side) of the membrane 11 close to the outlet 101 is opened to allow the reaction liquid to flow out from this end after crossing the membrane 11, and the first side 102 (outer side) of the membrane 11 is connected to the inlet 100 and not connected to the outlet 101, so that the dialysate waste can only enter the first side 102 from the inlet 100, and the reaction liquid can only flow out from the end of the second side 103 close to the outlet 101 after crossing the membrane 11.

[0066] In some embodiments, when the enzyme is disposed on the second side, the second side is connected to the inlet, and the first side is connected to the outlet. When the dialysis waste fluid flowing from the inlet fully contacts the enzyme on the second side and crosses the membrane to enter the first side, the enzyme is retained on the second side. Figure 5 , which is a cross-sectional schematic diagram of a reactor with a flat membrane in another embodiment of the present application, as shown in the figure, the enzyme 12 is arranged on the second side 103, the second side 103 is connected to the inlet 100 of the chamber 10, the dialysis waste liquid flows from the inlet 100 into the second side 103 and fully contacts the enzyme 12, and the reaction liquid crosses the membrane 11 along the direction indicated by the dotted arrow under the pressure provided by the dialysis liquid pump, and is discharged from the outlet 101 of the first side 102, and the enzyme 12 is retained on the second side 103. In another example, please refer to Figure 6 , which is a cross-sectional schematic diagram of a reactor having a hollow fiber membrane in another embodiment of the present application. As shown in the figure, a plurality of membranes 11 are arranged in the cavity 10 of the reactor 1. The membrane 11 is a hollow fiber membrane. The hollow fiber membrane has an inner side and an outer side. The outer side of the membrane 11 is a first side 102, and the inner side of the membrane 11 is a second side 103. The enzyme 12 is arranged on the second side 103. The second side 103 of each membrane 11 is connected to the inlet 100 of the cavity 10. After the dialysate flows in from the inlet 100, it fills the second sides 103 of the plurality of membranes 11 and fully contacts with the enzyme 12 on the second side 103. After the reaction is completed, the reaction liquid crosses the membrane 11 in the direction indicated by, for example, the dotted arrow under the pressure provided by the dialysate pump, and then flows from the first side 102 of the membrane 11 to the outlet 101, and the enzyme 12 is retained on the second side 103. It should be noted that in Figure 6 In the illustrated embodiment, one end of the second side 103 (inner side) of the membrane 11 close to the inlet 100 is opened to allow the dialysate waste to flow into the second side 103 from this end, and one end of the second side 103 (inner side) of the membrane 11 close to the outlet 101 is closed to prevent the reaction liquid from flowing out from this end, and the first side 102 (outer side) of the membrane 11 is not connected to the inlet 100, but connected to the outlet 101, so that the dialysate waste can only enter the second side 103 from the end of the second side 103 close to the inlet 100, and the reaction liquid after the reaction can only enter the first side 102 after crossing the membrane 11 and flow out from the outlet 101.

[0067] In some embodiments, the inlet and outlet are arranged at a vertical angle. Figures 3 to 6 As shown, the inlet 100 and the outlet 101 are both arranged at a vertical angle, which can reduce pressure loss compared to the inlet and outlet being arranged in a horizontal direction, ensuring that there is enough pressure to force the reaction liquid to cross the membrane 11, thereby improving the flow efficiency of the fluid.

[0068] It should be noted that although Figures 3 to 6 In the example, the inlet and the outlet are arranged at a vertical angle, but the present application does not limit the angle between the inlet and the outlet. In other embodiments, the inlet and the outlet may be parallel to each other or may be at an acute angle or an obtuse angle.

[0069] It should be noted that, influenced by factors such as the type of membrane, according to the description of the working principle of the reactor of the application in the above embodiment, the reactor can be designed in various forms and is not limited to Figures 3 to 6 Example of a reactor as described.

[0070] In any of the above embodiments, the enzyme located on the first side or the second side is formulated in a free state, so that the toxin concentration in the dialysis waste fluid that the enzyme contacts can be similar, thereby solving the problem of serious activity loss caused by enzymes at different positions not contacting dialysis waste fluid of sufficient concentration.

[0071] In one embodiment, see Figure 7a , which is a schematic diagram of the principle of a dialysate regeneration system including a first adsorption device in one embodiment of the present application. As shown in the figure, the dialysate regeneration system also includes a first adsorption device 24 disposed upstream of the reactor 1, and the first adsorption device 24 is used to perform preliminary toxin treatment on the dialysis waste liquid. Specifically, the output end of the first adsorption device 24 is connected to the inlet of the reactor 1, so that the dialysis waste liquid that has been preliminarily toxin treated by the first adsorption device 24 enters the reactor 1 from the inlet of the reactor 1 for deep toxin treatment. In one example, the first adsorption device 24 is mainly used to adsorb potassium, calcium, magnesium and other ions in the dialysis waste liquid.

[0072] In some embodiments, the first adsorption device may include one or more adsorption materials. Among them, the adsorption material includes activated carbon, a cation exchanger, or an anion exchanger, etc. The cation exchanger includes zirconium phosphate, or a cation exchange resin, etc., and the anion exchanger includes hydrated zirconium oxide, zirconium hydroxide, sodium zirconium carbonate, or anion exchange resin, etc. In one example, the first adsorption device includes one adsorption material. For example, the first adsorption device may only include one activated carbon column. In another example, the first adsorption device includes multiple adsorption materials. For example, the first adsorption device is a mixed column of activated carbon and anion exchanger. For another example, the first adsorption device is a mixed column of activated carbon and a cation exchanger. For another example, the first adsorption device is a mixed column of anion exchanger and a cation exchanger. For another example, the first adsorption device is a mixed column of activated carbon, anion exchanger, and a cation exchanger. Among them, the activated carbon material is used to adsorb organic matter, the cation exchanger is used to adsorb various cationic substances, including potassium, calcium, magnesium, etc., and the anion exchanger is used to adsorb various anionic substances, such as phosphate, acetate, etc. In the following embodiments, the first adsorption device is provided with a plurality of materials as an example for description.

[0073] In one embodiment, if Figure 7aAs shown, the first adsorption device 24 is configured as a single mixed column containing multiple adsorption materials. The first adsorption device 24 includes a multilayer material designed to remove pollutants and uremic solutes while retaining appropriate dialysate components. Waste dialysate flows through the first adsorption device 24 from downstream to upstream. The layer in contact with the dialysate contains activated carbon. These layers absorb heavy metals, chloramines and other pollutants that may be found in tap water. In addition, activated carbon absorbs many organic and middle molecular uremic solutes found in waste dialysate, including creatinine and uric acid. The multilayer material includes a zirconium phosphate layer and is a cation exchange layer. Its main function is to adsorb ammonium ions produced by urea hydrolysis. In addition, this cation exchange material absorbs other positively charged substances, such as magnesium, calcium and potassium, and heavy metal cations that may be found in tap water, such as copper and iron. For the adsorbed cations, in order to achieve exchange, the zirconium phosphate releases or and sodium. The multilayer material also includes an anion exchange layer containing hydrated zirconium oxide. The material adsorbs phosphate, fluoride and other anions, such as oxygen anions of heavy metals, and releases water or hydroxide anions in exchange. It should be understood that the upstream and downstream relationships are determined based on the flow direction of the liquid, with the first flow being the upstream and the second flow being the downstream, rather than the up-and-down relationship in physical space. Generally, the adsorption column flows from bottom to top, so the adsorption material downstream is often in the upper layer.

[0074] In another embodiment, the first adsorption device includes a plurality of columns connected in series, such as columns containing zirconium phosphate, hydrated zirconium oxide, and activated carbon materials, respectively, connected in series. It should be noted that the present application does not limit the number of columns connected in series in the first adsorption device, which may include two or more adsorption columns, and each adsorption column may also include one or more adsorption materials.

[0075] In this embodiment, one or more of a pressure sensor, a degassing device, and a pH sensor may be provided between the plurality of columns connected in series.

[0076] In another embodiment, if Figure 7bAs shown, it is a schematic diagram of the principle of a dialysate regeneration system including a second adsorption device in one embodiment of the present application. As shown in the figure, the dialysate regeneration system also includes a second adsorption device 25, the input end of the second adsorption device 25 is connected to the outlet of the reactor 1. In other words, the second adsorption device 25 is located downstream of the reactor 1, and is used to treat the waste liquid after the urea decomposition of the reactor again. For example, the second adsorption device 25 is mainly used to adsorb toxins such as ammonium ions formed after creatinine, phosphate, and urea are decomposed, and also adsorb potassium, calcium, magnesium and other ions. In some embodiments, the second adsorption device may also include one or more adsorption materials. In an embodiment in which the second adsorption device is configured with multiple adsorption materials, the second adsorption device can be configured as a single mixed column containing multiple adsorption materials, or it can be configured to include multiple columns connected in series, wherein each column contains one or more adsorption materials. The material composition of the second adsorption device is the same or similar to the above-mentioned example of the first adsorption device, and will not be described in detail here. The size of its column, the filling ratio of the adsorption material, and the filling amount of the adsorption material can be the same as or different from those of the first adsorption device. For example, the column of the second adsorption device is larger than the column of the first adsorption device.

[0077] In yet another embodiment, see Figure 7c , which is a schematic diagram of the principle of a dialysate regeneration system including first and second adsorption devices in one embodiment of the present application. As shown in the figure, the dialysate regeneration system includes the first adsorption device and the second adsorption device to enhance the toxin removal effect.

[0078] In one embodiment, if Figure 1 As shown, the regeneration liquid pipeline L2-2 is connected to the outlet of the reactor 1 for receiving the reaction liquid after the reaction treatment of the reactor 1. The output end of the regeneration liquid pipeline can be directly connected to the regeneration liquid container for storing the regeneration liquid, or it can be connected to the inlet of the regeneration liquid of the peritoneal dialysis (PD) device, and it can also be connected to the inlet of the regeneration liquid of the hemodialysis (HD) device. It should be noted that the present application does not limit the specific connection position and connection form of the output end of the regeneration liquid pipeline. It is only necessary to meet the output end of the regeneration liquid pipeline with an inlet or device that can receive the regeneration liquid. In one example, the dialysate regeneration system is used in a peritoneal dialysis device, and the output end of the regeneration liquid pipeline is connected to the peritoneal dialysis pipeline in the peritoneal dialysis device for inputting the regeneration liquid into the channel for inputting the regeneration liquid in the peritoneal dialysis pipeline. In another example, the dialysate regeneration system is used in a hemodialysis device, and the output end of the regeneration liquid pipeline is connected to the dialysate input end of the dialysis device in the hemodialysis device for inputting the regeneration liquid into the dialysis device.

[0079] In one embodiment, if Figure 2 and Figure 8 As shown, Figure 8 The schematic diagram of the principle of the dialysate regeneration system in another embodiment of the present application is shown, and the regeneration liquid pipeline L2-2 is provided with a supplementary liquid branch L2-4 for conveying supplementary liquid to the regeneration liquid pipeline L2-2. Specifically, the supplementary liquid branch L2-4 is used to supplement the supplementary liquid in the regeneration liquid pipeline L2-2 to form a regeneration liquid that can be used again for dialysis treatment.

[0080] In one embodiment, please continue to refer to Figure 2 and Figure 8 As shown in the figure, the replenishing liquid branch L2-4 is provided with a container 41 for storing replenishing liquid, and a replenishing liquid pump 40 for transporting the replenishing liquid in the container 41 to the replenishing liquid branch L2-4. In one example, the replenishing liquid includes an electrolyte solution. In another example, the replenishing liquid includes a hypertonic solute solution. In yet another example, the replenishing liquid includes an electrolyte solution and a hypertonic solute solution.

[0081] In one embodiment, the hypertonic solute includes glucose. In one example, the glucose in the hypertonic solute is configured to be 1.5% to 70%. For example, the concentration of glucose in the hypertonic solute is 1.5%, 2%, 2.5%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, or 70%.

[0082] In one embodiment, the electrolyte solution is configured to include potassium, calcium and magnesium. For example, the supplement solution is a potassium, calcium and magnesium concentrate. In one example, the concentration range of potassium, calcium and magnesium can be configured to be 0 to 100mmol / L. For example, the total concentration range of potassium, calcium and magnesium in the electrolyte solution can be configured to be 0, 10mmol / L, 20mmol / L, 30mmol / L, 40mmol / L, 50mmol / L, 60mmol / L, 70mmol / L, 80mmol / L, 90mmol / L, or 100mmol / L. Further, in one embodiment, the electrolyte solution also includes magnesium, sodium, chlorine, alkali, etc.

[0083] In some embodiments, a temperature control device is further provided in the waste liquid passage and / or the regeneration liquid pipeline. The temperature control device is used to control the temperature of the fluid in the waste liquid passage and / or the regeneration liquid pipeline within a preset range. The temperature control device is exemplified by a heating device or a constant temperature device.

[0084] In some embodiments, a leakage sensor is provided on the waste liquid passage. In one embodiment, a pressure sensor for detecting the pressure of dialysis waste liquid is provided on the waste liquid passage. Furthermore, a hydrophobic filter is provided between the waste liquid passage and the pressure sensor, and the permeability of the hydrophobic filter enables the pressure sensor to detect the waste liquid pressure in the waste liquid passage.

[0085] The present application also provides a peritoneal dialysis device for dialysis treatment, the peritoneal dialysis device comprising a peritoneal dialysis circuit, a drive device, a control device, and a dialysate regeneration system connected to the peritoneal dialysis circuit. In order to facilitate the distinction from the drive device and the control device in the hemodialysis device described later, the control device and the drive device of the peritoneal dialysis device are respectively referred to as the first control device and the first drive device, and the control device and the drive device of the hemodialysis device are respectively referred to as the second control device and the second drive device.

[0086] See also Fig. 9 , which is a schematic diagram of the principle of a peritoneal dialysis device in one embodiment of the present application, as shown in the figure, the peritoneal dialysis device includes a peritoneal dialysis circuit L1, a first driving device 51, a first control device 52, and a dialysate regeneration system connected to the peritoneal dialysis circuit L1. One end of the peritoneal dialysis circuit L1 is connected to the peritoneal cavity 50 of the human body, and the other end thereof is connected to the dialysate regeneration system. The first control device 52 executes a treatment mode to control the first driving device 51 to drive the fluid to flow periodically or continuously in the peritoneal dialysis circuit L1, so that the peritoneal dialysis circuit L1 inputs the dialysate waste fluid in the peritoneal cavity of the human body into the dialysate regeneration system, and receives the regeneration fluid generated by the dialysate regeneration system, thereby realizing the periodic or continuous exchange of the fluid in the peritoneum of the human body.

[0087] The communication mode and working principle of the dialysate regeneration system are as described above for Figures 1 to 8 The methods described in the various embodiments and the related descriptions will not be repeated here.

[0088] In some embodiments, the peritoneal dialysis circuit includes two single-channel peritoneal dialysis catheters or one dual-channel peritoneal dialysis catheter. In one example, the peritoneal dialysis catheter is configured as a single channel, and the peritoneal dialysis circuit includes two single-channel peritoneal dialysis catheters, one peritoneal dialysis catheter is used to output dialysis waste liquid, and the other peritoneal dialysis catheter is used to input regeneration liquid. In other words, the channel of one peritoneal dialysis catheter is connected to the input end of the waste liquid passage, and the channel of the other peritoneal dialysis catheter is connected to the output end of the regeneration liquid pipeline. In another example, the peritoneal dialysis catheter is configured as a dual channel, specifically, a peritoneal dialysis catheter includes two channels. Among them, one channel is used to output dialysis waste liquid, and the other channel is used to input regeneration liquid; in other words, one channel is used to communicate with the input end of the waste liquid passage, and the other channel is used to communicate with the output end of the regeneration liquid pipeline. For the sake of convenience, the channel for outputting dialysis waste liquid is referred to as the first channel, and the channel for inputting regeneration liquid is referred to as the second channel. In the following embodiments, the peritoneal dialysis catheter is configured as a dual channel as an example for explanation.

[0089] See also Figures 10a to 10c , respectively, are schematic diagrams of dual-channel peritoneal dialysis catheters in different embodiments of the present application. As shown in the figure, the first channel L1-1 and the second channel L1-2 of the peritoneal dialysis catheter can be as follows Fig.10a As shown in FIG. 1 , the two channels of the peritoneal dialysis catheter are arranged in parallel, and one end connected to the dialysate regeneration system can be as follows: Fig.10b The acute angle configuration shown can also be Fig.10c Shown in a 180 degree configuration.

[0090] In one embodiment, after a dual-channel peritoneal dialysis catheter is placed in the peritoneal cavity, the regeneration fluid can enter from the second channel and the dialysis waste fluid can flow out from the first channel. In this way, the fluid flow rate flowing into the peritoneal cavity and the fluid flow rate flowing out of the peritoneal cavity can be kept the same, thereby enabling the peritoneal dialysis device to achieve CFPD (continuous flow peritoneal dialysis) mode.

[0091] In one embodiment, if Fig. 9 As shown, the peritoneal dialysis line L1 is also provided with a dialysate line L3, and the dialysate line L3 is connected to the peritoneal dialysis line L1 for inputting the dialysate into the peritoneal cavity 50. It should be noted that during the process of inputting the dialysate into the peritoneal cavity 50, one end of the peritoneal dialysis line L1 for outputting the dialysis waste liquid (the outlet of the dialysis waste liquid of the peritoneal dialysis line L1) is closed, and after the dialysate input is completed, that is, after the preset input amount is reached, the dialysate line L3 is closed and the inlet of the regeneration liquid and the outlet of the dialysis waste liquid of the peritoneal dialysis line L1 are opened. It should be noted that in order to realize the above process, the dialysate line L3 may be provided with a pump for driving the dialysate to flow into the peritoneal cavity, and the peritoneal dialysis line L1 may be provided with a valve that can realize the conduction and closure of the line.

[0092] After the dialysate is input into the peritoneal cavity 50 of the human body, the first driving device 51 provided on the peritoneal dialysis line L1 can drive the fluid to flow periodically or continuously in the peritoneal dialysis line L1. In one example, the first driving device 51 continuously drives the dialysis waste liquid to flow from the outlet of the dialysis waste liquid of the peritoneal dialysis line L1 into the waste liquid passage L2-1 of the dialysis fluid regeneration system. The dialysis waste liquid is decomposed by the dialysis fluid regeneration system to form a regeneration liquid, and the regeneration liquid flows from the regeneration liquid line L2-2 of the dialysis fluid regeneration system into the regeneration liquid inlet of the peritoneal dialysis line L1. In this way, the fluid flows continuously in the peritoneal dialysis line L1. In another example, the first driving device 51 periodically drives the dialysis waste liquid to flow from the outlet of the dialysis waste liquid of the peritoneal dialysis line L1 into the waste liquid passage L2-1 of the dialysis fluid regeneration system to achieve periodic flow of the fluid in the peritoneal dialysis line L1.

[0093] The first driving device 51 includes one or more pumps provided on the peritoneal dialysis pipeline L1, and the pump is used to provide power to the fluid in the pipeline so that the fluid circulates in a preset flow direction. In an embodiment, the pump can be a peristaltic pump, a pneumatic diaphragm pump, or a pressure pump. Here, in the application scenario for medical purposes, the first driving device 51 should not directly contact the fluid, but only apply pressure to the pipeline and drive the fluid to flow. The preferred embodiment of the first driving device 51 is a non-contact pump device such as a peristaltic pump or a pneumatic diaphragm pump. The forward and reverse (reversal) rotation of the peristaltic pump will cause the flow direction of the fluid in the peritoneal dialysis pipeline L1 to be different.

[0094] When the dialysate regeneration system is configured in the peritoneal dialysis device, the first driving device can also serve as a dialysate pump of the dialysate regeneration system. In other words, the dialysate pump configured on the waste fluid passage can be replaced by the first driving device. In other embodiments, a dialysate pump can also be configured in the dialysate regeneration system on the basis of configuring the first driving device to improve the driving effect on the fluid.

[0095] The first control device 52 is used to execute the treatment mode to periodically or continuously exchange the fluid in the human peritoneum. In an embodiment, the first control device 52 is, for example, a controller or system processor of a peritoneal dialysis device, which outputs corresponding control instructions by writing a program in the system processor; or receives a trigger instruction input by an operator through an input device such as a touch screen to execute the relevant control instructions. Among them, in the treatment mode, the peritoneal dialysis device can achieve periodic or continuous exchange of fluid in the human peritoneum. Specifically, the peritoneal dialysis device can continuously suck out the dialysis waste fluid from the human peritoneal cavity and continuously input the regeneration fluid into the human peritoneal cavity by controlling the periodic flow or continuous flow of the fluid to achieve dialysis.

[0096] In some embodiments, the peritoneal dialysis device is configured as a combination of one or more treatment modes of CAPD treatment mode, APD treatment mode, TPD treatment mode, and CFPD treatment mode. In one example, the peritoneal dialysis device can be configured only as CAPD treatment mode, APD treatment mode, TPD treatment mode, or CFPD treatment mode. In another example, the peritoneal dialysis device is configured as a combination of multiple treatment modes of CAPD treatment mode, APD treatment mode, TPD treatment mode, and CFPD treatment mode. For example, the peritoneal dialysis device includes a mode selection device, and the mode selection device is used to receive an input mode selection signal and send the determined working mode information to the first control device to perform the operation corresponding to the working mode, so that the peritoneal dialysis device can achieve a combination of multiple treatment modes.

[0097] In a specific embodiment, the peritoneal dialysis device is configured in CFPD mode, and the peritoneal dialysis catheter is configured as a dual-channel. When the dialysate in the peritoneal cavity reaches the required amount, one channel in the peritoneal dialysis catheter continuously outputs dialysis waste fluid, and the other channel continuously inputs regeneration fluid, thereby maintaining the same fluid flow rate flowing into the peritoneal cavity and the fluid flow rate flowing out of the peritoneal cavity, thereby enabling the peritoneal dialysis device to achieve CFPD (continuous flow peritoneal dialysis) mode.

[0098] It should be noted that although the CAPD treatment mode, APD treatment mode, TPD treatment mode, and CFPD treatment mode are used as examples in the embodiments of the present application, it is not limited to this. In other embodiments, the peritoneal dialysis device can also be configured as other periodic or continuous treatment modes.

[0099] The peritoneal dialysis device of the present application achieves the effect of dialysis with a large amount of dialysate by recycling and regenerating the dialysate waste fluid. For example, after the present application uses 1L of dialysate to perform the treatment mode for 8 hours, it can be equivalent to the dialysis effect of dialysis with 48L of dialysate in the APD or CAPD mode. In addition, the peritoneal dialysis device of the dialysate recycling and regeneration mode of the present application does not require a water source and a water treatment system, so it is very small and portable, suitable for home dialysis and wearable dialysis equipment.

[0100] In one embodiment, see Fig.11, which is a schematic diagram of the principle of a hemodialysis device in one embodiment of the present application, as shown in the figure, the hemodialysis device includes a dialysis device 61, a second drive device 60, a second control device 62, a purification circuit, and a dialysate regeneration system. The second control device 62 executes a treatment mode to control the second drive device 60 to drive the fluid to flow in the purification circuit, the dialysis device 61 purifies the fluid flowing in the purification circuit and inputs the generated dialysis waste fluid into the dialysis fluid regeneration system, and the dialysis waste fluid is purified by the dialysis fluid regeneration system and then input into the human body through the purification circuit.

[0101] The input end of the waste liquid passage L2-1 of the dialysate regeneration system is connected to the dialysis device 61 to obtain the dialysate waste liquid from the dialysis device 61. Specifically, the input end of the waste liquid passage L2-1 is connected to the dialysate output end 610 of the dialysis device 61 to obtain the dialysate waste liquid output by the dialysate output end 610, and the output end of the regeneration liquid pipeline L2-2 can be connected to the dialysate input end 611 of the dialysis device 61 to input the regeneration liquid into the dialysis device 61.

[0102] The communication mode and working principle of the dialysate regeneration system are as described above for Figures 1 to 8 The methods described in the various embodiments will not be repeated here.

[0103] The purification circuit includes a first line L4, i.e., an arterial blood line, whose input end is connected to the first part of the human body, and a second line L5, i.e., a venous blood line, whose output end is connected to the second part of the human body. In the treatment mode of the hemodialysis device, an arterial puncture needle is connected to the front end of the first line L4 through a connector, and a second drive device 60, such as a peristaltic device, is set in the middle. On the other hand, a venous puncture needle is connected to the front end of the second line L5 through a connector, and a drip chamber / venous pot or a gas collecting chamber with the function of a venous pot is connected in the middle. In addition, during dialysis treatment, the arterial puncture needle and the venous puncture needle are punctured into the target arterial blood vessel and the target venous blood vessel of the patient's body respectively. If the second drive device 60 works, the patient's blood reaches the dialysis device 61 through the first line L4, and then the blood is purified through the dialysis device 61, while debubbling is performed in the drip chamber / venous pot, and the blood is returned to the patient's body through the second line L5. That is, the patient's blood is circulated from the front end of the first line L4 to the front end of the second line L5 in vitro, while the blood is purified through the dialysis device 61.

[0104] The second drive device 60 is arranged on the first line L4 and is located in the purification circuit, and is used to drive the fluid to flow in the purification circuit; in an embodiment, the second drive device 60 includes but is not limited to a peristaltic pump, a pneumatic diaphragm pump, or a pressure pump, which is used to provide power to the fluid in the pipeline so that the fluid circulates in a preset flow direction. Here, in the application scenario for medical purposes, the second drive device 60 should not directly contact the fluid, but only apply pressure to the pipeline and drive the fluid to flow. The preferred embodiment of the second drive device 60 is a non-contact pump device such as a peristaltic pump or a pneumatic diaphragm pump. More specifically, the peristaltic pump is, for example, a dialysis pump or a blood pump. The forward and reverse (reversal) rotation of the peristaltic pump will cause the flow direction of the fluid in the circulation loop to be different.

[0105] It should be understood that the second driving device 60 can drive the fluid in the pipeline at different positions in the pipeline, and its flow rate may change due to factors such as pipeline resistance, temperature, and pressure in the direction of fluid flow. However, in the embodiment provided in the present application for application in the field of hemodialysis, the second driving device 60 is arranged on the arterial blood line of the purification circuit.

[0106] The second control device 62 is used to execute the treatment mode to purify the fluid flowing in the purification circuit and then input it into the human body. In an embodiment, the second control device 62 is, for example, a controller or a system processor of a hemodialysis device, which outputs corresponding control instructions through a program written into the system processor; or receives a trigger instruction input by an operator to execute the relevant control instructions.

[0107] The dialysis device 61 is arranged on the purification circuit, and is used to purify the fluid flowing in the purification circuit. The dialysis device 61 includes a dialysate output end 610 and a dialysate input end 611. The dialysate output end 610 is connected to the input end of the waste liquid passage L2-1 to input the dialysis waste liquid into the waste liquid passage L2-1, and the dialysate input end 611 is connected to the output end of the regeneration liquid pipeline L2-2, and is used to receive the regeneration liquid input by the regeneration liquid pipeline L2-2. The dialysis device 61 can use the regeneration liquid to purify the fluid (blood) flowing in the purification circuit.

[0108] In an embodiment, the dialysis device is used to purify the fluid (blood) flowing in the purification circuit, and forms a blood flow path for the patient's blood to flow and a dialysate flow path for the dialysate to flow through a built-in purification membrane for blood purification; in an embodiment, the dialysis device includes a dialysate chamber, a blood chamber and a semi-permeable membrane, etc., and the membrane separates the dialysis chamber and the blood chamber from each other. In the commonly used capillary dialysis device, the blood chamber is formed by the entire internal volume of the hollow fiber, and the dialysate chamber is formed by the inner cavity of the shell of the dialysis device surrounding the hollow fiber. In an embodiment, the top end of the dialysis device is connected to the arterial blood line, and the bottom end of the dialysis device is connected to the venous blood line.

[0109] In one embodiment, the dialysis device is a hemodialyzer, a hemodiafiltration device, a hemofilter, a plasma separator, or a blood plasma component separator, etc., and the present application is used as long as the device can separate toxins or molecular components in the blood. In an embodiment, the dialysis device includes a combination of one or more treatments of hemodialysis (HD), hemofiltration (HF), hemodiafiltration (HDF), hemoperfusion (HP), blood exchange (PE), immunoadsorption (IA), or continuous blood purification (CRRT).

[0110] In some embodiments, the hemodialysis equipment includes at least one detection device, which is used to detect the concentration of target molecules in the dialysis waste fluid, detect the content of enzyme-loaded microspheres in the waste fluid passage L2-1 (such as detecting the amount of enzyme-loaded microspheres added or whether they are cleared), or detect the content of enzyme-loaded microspheres in the regeneration fluid pipeline L2-2.

[0111] In some embodiments, the hemodialysis device further comprises a mode selection device, which is used to receive an input mode selection signal and send the determined working mode information to the second control device to perform the operation corresponding to the working mode. In this embodiment, the working mode includes a combination of one or more treatment modes of HF treatment mode, HD treatment mode, HDF treatment mode, and ultrafiltration mode.

[0112] In the HF treatment mode, the second control device controls the regeneration fluid output by the dialysate regeneration system to be directly input into the first circuit or the second circuit. Fig.12 , showing the principle diagram of the hemodialysis device of the present application in the pre-dilution mode, as shown in the figure, the second control device 62 controls the regeneration fluid output by the dialysate regeneration system to be directly input into the first line L4, such as the arterial pot 63. This mode of directly inputting the regeneration fluid into the arterial pot 63 can be called the pre-dilution mode. In another embodiment, please refer to Fig.13, showing the schematic diagram of the hemodialysis device of the present application in the post-dilution mode. As shown in the figure, the second control device 62 controls the regeneration fluid output by the dialysate regeneration system to be directly input into the second line L5, such as the venous pot 64. This mode of directly inputting the regeneration fluid into the venous pot 64 can be called the post-dilution mode.

[0113] In the HD treatment mode, the second control device controls the regeneration fluid output by the dialysate regeneration system to be input to the dialysate input end of the dialysis device. Fig.11 As shown, the second control device 62 controls the regeneration fluid output by the dialysate regeneration system to be directly input into the dialysate input end 611 of the dialysis device 61 .

[0114] In the present application, the hemodialysis equipment can also realize the design of HDF treatment mode, that is, hemodiafiltration with dynamic control of the total amount of (circulating dialysate). In an embodiment, the total amount of liquid in the dialysate circulation is regulated by dynamically and periodically regulating the volume or liquid level of any container in the dialysate circulation, thereby achieving periodic filtration and filtration, and increasing the molecular convection exchange of the dialyzer.

[0115] In the HDF treatment mode, the control device controls the regeneration fluid output by the dialysate regeneration system to be input into the first circuit or the second circuit via a replacement fluid branch. The replacement fluid branch is arranged on the regeneration fluid pipeline, one end of the replacement fluid branch is connected to the regeneration fluid pipeline, and the other end is used to connect to the dialysis circuit.

[0116] In one embodiment, see Fig.14 , which is a schematic diagram of the HDF treatment mode in one embodiment of the hemodialysis device of the present application. As shown in the figure, the second control device 62 controls the regeneration fluid output by the dialysate regeneration system to be input into the first line L4, such as the arterial pot 63, through the replacement fluid branch L6. This mode of directly inputting the regeneration fluid into the arterial pot 63 can be called a pre-dilution mode. Among them, a replacement fluid pump 65 is provided on the replacement fluid branch L6 for transporting the regeneration fluid to the dialysis circuit. Furthermore, in one embodiment, the replacement fluid branch also includes a bacterial filter to filter the regeneration fluid again before inputting it into the dialysis circuit.

[0117] In one embodiment, see Fig.15 , which is a schematic diagram of the HDF treatment mode of the hemodialysis device of the present application in another embodiment, such as Fig.15As shown, in another embodiment of the HDF treatment mode, the second control device 62 controls the regeneration fluid output by the dialysate regeneration system to be input into the second line L5, such as the venous pot 64, through the substitution fluid branch L6. This mode of directly inputting the regeneration fluid into the venous pot 64 can be called a post-dilution mode. Among them, a substitution fluid pump 65 is provided on the substitution fluid branch L6 for transporting the regeneration fluid to the dialysis circuit. Furthermore, in one embodiment, the substitution fluid branch also includes a bacterial filter to filter the regeneration fluid again before inputting it into the dialysis circuit.

[0118] exist Fig.14 or Fig.15 In the embodiment of the HDF treatment mode, the second control device 62 adjusts the output of the replacement fluid branch L6 by periodically and dynamically adjusting the liquid volume in the waste liquid passage L2-1, the reactor 1, or the regeneration liquid pipeline L2-2 to control the molecular convection exchange volume of the dialysis device 61. In one embodiment, the second control device 62 adjusts the output of the replacement fluid branch L6 by dynamically adjusting the working cycle or power of the dialysate pump 20 to adjust the liquid volume in the reactor 1, thereby controlling the molecular convection exchange volume of the dialysis device 61.

[0119] In one embodiment, the second control device periodically changes the total amount of liquid equilibrium state of the dialysate circulation to periodically achieve filtration and filtration of the liquid inside and outside the dialyzer. In one embodiment, in the HDF treatment mode, changing the total amount of liquid equilibrium state of the dialysate circulation is to change the total amount of liquid equilibrium state of the dialysate circulation by adjusting the differential speed of two dialysate pumps, a first dialysate pump in the waste liquid passage and a second dialysate pump in the regeneration liquid pipeline.

[0120] In the embodiment of the ultrafiltration mode, the dialysate regeneration system is provided with an ultrafiltration branch, and the ultrafiltration branch diverts the dialysate waste in the waste liquid passage to increase the transmembrane pressure or negative pressure, so that the dialysis device filters an equal amount of liquid of the blood flowing through into the dialysate waste, thereby achieving dehydration. In this embodiment, an ultrafiltration container for storing ultrafiltrate and an ultrafiltration pump for transporting the ultrafiltrate in the ultrafiltration container to the waste liquid passage are provided on the ultrafiltration branch. In one example, the ultrafiltration container is, for example, an ultrafiltration bag, for example, a liquid bag made of medical plastic; the ultrafiltration pump can be a plunger roller pump, a peristaltic pump or a diaphragm pump, etc.

[0121] In an embodiment of the ultrafiltration mode, the second control device controls the rotation speed of the ultrafiltration pump or an empirical value to measure the flow rate of the dialysis waste liquid in the waste liquid passage diverted by the ultrafiltration branch. For example, in one embodiment, the second control device controls the rotation speed of the ultrafiltration pump by obtaining the volume or weight of the regeneration liquid in the regeneration liquid pipeline to measure the flow rate of the dialysis waste liquid in the waste liquid passage diverted by the ultrafiltration branch. For example, in another embodiment, the volume or weight of the regeneration liquid is obtained by weighing or liquid level measurement.

[0122] In one embodiment, when the dialysate regeneration system is applied to the dialysis cycle of the blood purification device, the ultrafiltration pump will continuously extract the water in the waste liquid passage to form a transmembrane negative pressure. At this time, the dialysis device will ultrafilter more water to achieve pressure balance. Ultimately, the blood loses as much water as the ultrafiltration pump extracts, thereby achieving the purpose of dehydration. In an actual embodiment, the ultrafiltration pump continuously pumps the dialysate waste in the waste liquid passage into a waste liquid bag. By accurately measuring the flow rate of the ultrafiltration pump, the excess water in the patient's body can be accurately extracted from the body, thereby achieving the purpose of dehydration.

[0123] In another embodiment, the ultrafiltration branch can also be arranged on the regeneration liquid pipeline, that is, the ultrafiltration branch includes a first ultrafiltration branch and a second ultrafiltration branch, wherein the first ultrafiltration branch is arranged on the waste liquid channel, and the second ultrafiltration branch is arranged on the regeneration liquid pipeline. In this embodiment, weighing-type ultrafiltration control is adopted, that is, dual pump control of an upstream pump and a downstream pump is adopted, wherein the upstream pump is arranged on the first ultrafiltration branch, and the downstream pump is arranged on the second ultrafiltration branch in the regeneration liquid pipeline. The container such as an ultrafiltration bag connected to the second ultrafiltration branch contains treated regeneration liquid. There is a weighing device under the ultrafiltration bag. The weighing device can obtain the content of the regeneration liquid in the ultrafiltration bag by weighing, and adjust the speed of the upstream pump and the downstream pump by controlling the speed. For example, if the water in the ultrafiltration bag exceeds the preset value (ultrafiltration curve), it means that more water is ultrafiltered, so the speed of the upstream pump is lowered and the speed of the downstream pump is increased at the same time; conversely, if the water in the ultrafiltration bag is lower than the preset value (ultrafiltration curve), the speed of the upstream pump can be increased and the speed of the downstream pump can be lowered.

[0124] It should be noted that those skilled in the art can adaptively add corresponding pumps, valves, and / or sensors and other components according to the principle description in the embodiments of the present application. For example, valves can be respectively provided at the ends of the first circuit and the second circuit connected to the human body. For another example, a valve can also be provided on the replacement fluid branch.

[0125] In summary, in the dialysate regeneration system and dialysis equipment provided by the present application, the inlet of the dialysate waste liquid of the reactor is connected to the side of the membrane equipped with the enzyme, and the outlet of the reaction liquid of the reactor is connected to the other side of the membrane (the side not equipped with the enzyme). Under this structure, after the dialysate waste liquid flows in from the inlet, the reaction liquid after reacting with the enzyme needs to be pushed by pressure to cross the membrane before it can flow out through the outlet on the other side. Further, after the dialysate waste liquid enters the side of the reactor with the enzyme in the present application, it can directly contact the enzyme instead of only part of the substance contacting the enzyme through diffusion. In this way, before crossing the membrane, the dialysate waste liquid is in continuous contact with the enzyme for a long time by directly impacting the enzyme, which can avoid some toxins from not being able to contact the enzyme or having a short contact time. This leads to insufficient toxin removal / decomposition; and the reaction liquid of the present application is discharged directly from the outlet on the other side after crossing the membrane, without the need to be discharged from the outlet on the same side as the inlet through a reciprocating transmembrane method, and does not need to be contacted with the enzyme through a circulating flow, thereby improving the efficiency of toxin removal / decomposition; further, the enzyme in the reactor is formulated in a free state, which can make the concentration of toxins in the dialysis waste liquid contacted by the enzyme similar, solving the problem of serious loss of activity due to enzymes at different positions not being able to contact dialysis waste liquid of sufficient concentration; the membrane of the present application is trapped on the side where the enzyme is located, which can enable the enzyme to continuously and efficiently decompose toxins on the first side, so as to avoid the problem of low toxin decomposition efficiency caused by a reduction in the number of enzymes. The regenerated liquid output by the reactor can be used again in the dialysis process, thus achieving the effect of using a small amount of dialysate to achieve a large amount of dialysate for abdominal and hemodialysis.

[0126] The above embodiments are merely illustrative of the inventive essence of the present application and the beneficial effects obtained, and are not intended to limit the present application. Anyone familiar with the technology may modify or change the above embodiments without violating the principles and scope of the present application. Therefore, all equivalent modifications or changes achieved by a person with ordinary knowledge in the technical field without departing from the spirit and technical ideas disclosed in the present application shall still be covered by the claims of the present application.

Claims

1. A dialysate regeneration system, characterized in that: include: A waste liquid passage, an input end of which receives dialysis waste liquid; A reactor, disposed in the waste liquid passage, for decomposing toxins in the dialysis waste liquid; The reactor comprises: The cavity has an inlet for the dialysis waste liquid to flow in and an outlet for the reaction liquid to flow out; A membrane having a first side and a second side, disposed in the cavity, wherein an enzyme is disposed on the first side or the second side of the membrane; Wherein, one side of the membrane equipped with the enzyme is connected to the inlet, and the other side is connected to the outlet. After the dialysis waste liquid flowing in from the inlet is fully in contact with the enzyme, it flows across the membrane to the outlet, and the enzyme is retained by the membrane on the side where the enzyme is located; The regeneration liquid pipeline is connected to the outlet to receive the reaction liquid after the reaction treatment in the reactor.

2. The dialysate regeneration system according to claim 1, characterized in that: When the enzyme is arranged on the first side, the first side is connected to the inlet, and the second side is connected to the outlet. When the dialysis waste fluid flowing in from the inlet fully contacts with the enzyme on the first side and crosses the membrane to enter the second side, the enzyme is retained on the first side.

3. The dialysate regeneration system according to claim 1, characterized in that: When the enzyme is configured on the second side, the second side is connected to the inlet, and the first side is connected to the outlet. When the dialysis waste fluid flowing in from the inlet fully contacts with the enzyme on the second side and crosses the membrane into the first side, the enzyme is retained on the second side.

4. The dialysate regeneration system according to claim 1, characterized in that: The inlet and the outlet are arranged at a perpendicular angle.

5. The dialysate regeneration system according to claim 1, characterized in that: The enzyme is configured as urease.

6. The dialysate regeneration system according to claim 1, characterized in that: The enzyme disposed on the first side or the second side of the membrane is formulated in a free state.

7. The dialysate regeneration system according to claim 1 or 6, characterized in that: The enzyme can be carried in the form of enzyme preparation or enzyme-loaded microspheres.

8. The dialysate regeneration system according to claim 1, characterized in that: The reactor is used for decomposing urea in the dialysis waste liquid.

9. The dialysate regeneration system according to claim 1, characterized in that: The invention also comprises a first adsorption device arranged upstream of the reactor and used for performing preliminary toxin treatment on the dialysis waste liquid.

10. The dialysate regeneration system according to claim 1, characterized in that: It also includes a second adsorption device, whose input end is connected to the outlet and is used for re-treating the waste liquid after urea decomposition in the reactor.

11. The dialysate regeneration system according to any one of claims 9 or 10, characterized in that: The first or second adsorption device is configured as a single mixing column containing a plurality of adsorption materials.

12. The dialysate regeneration system according to any one of claims 9 or 10, characterized in that: The first or second adsorption device comprises a plurality of columns connected in series, wherein each column contains one or more adsorption materials.

13. The dialysate regeneration system according to claim 9, characterized in that: The first adsorption device comprises an activated carbon column; or a mixed column of activated carbon and anion exchanger; or a mixed column of activated carbon and cation exchanger; or a mixed column of anion exchanger and cation exchanger; or a mixed column of activated carbon, anion exchanger, and cation exchanger.

14. The dialysate regeneration system according to claim 10, characterized in that: The second adsorption device is configured as an adsorption column comprising potassium phosphate, hydrated zirconium oxide, and activated carbon.

15. The dialysate regeneration system according to claim 1, characterized in that: The waste liquid passage is provided with a dialysate pump for driving the fluid in the waste liquid passage to flow in a forward direction or a reverse direction.

16. The dialysate regeneration system according to claim 1, characterized in that: A first dialysate pump is provided on the waste liquid passage, and a second dialysate pump is provided on the regeneration liquid pipeline, for changing the total amount of liquid equilibrium state of the dialysate regeneration system through the differential speed of the first dialysate pump and the second dialysate pump.

17. The dialysate regeneration system according to claim 1, characterized in that: The waste liquid passage is provided with a prefabricated liquid bypass for prefilling, emptying, or flushing the passage of the dialysate regeneration system.

18. The dialysate regeneration system according to claim 1, characterized in that: The regeneration liquid pipeline is provided with a supplementary liquid branch for conveying supplementary liquid to the regeneration liquid pipeline.

19. The dialysate regeneration system according to claim 18, characterized in that: The replenishing liquid branch is provided with a container for storing replenishing liquid, and a replenishing liquid pump for conveying the replenishing liquid in the container to the replenishing liquid branch.

20. The dialysate regeneration system according to claim 19, characterized in that: The replenishing solution includes an electrolyte solution and / or a hypertonic solute solution.

21. The dialysate regeneration system according to claim 20, characterized in that: The hypertonic solute includes glucose.

22. The dialysate regeneration system according to claim 21, characterized in that: The glucose content in the hypertonic solute is 1.5% to 70%.

23. The dialysate regeneration system according to claim 20, characterized in that: The electrolyte solution is configured to include potassium, calcium and magnesium.

24. The dialysate regeneration system according to claim 23, characterized in that: The concentration range of potassium, calcium and magnesium can be configured to be 0 to 100 mmol / L.

25. A peritoneal dialysis device, characterized in that: include: The dialysate regeneration system according to any one of claims 1 to 24; A peritoneal dialysis pipeline, one end of which is connected to the human peritoneal cavity and the other end of which is connected to the dialysate regeneration system; A driving device, disposed on the peritoneal dialysis pipeline, for driving the fluid to flow periodically or continuously in the peritoneal dialysis pipeline; A control device is used to implement a treatment mode to periodically or continuously exchange fluid in the peritoneum of a human body.

26. The peritoneal dialysis device according to claim 25, characterized in that The peritoneal dialysis device is configured as a combination of one or more treatment modes of CAPD treatment mode, APD treatment mode, TPD treatment mode, and CFPD treatment mode.

27. The peritoneal dialysis device according to claim 25, characterized in that The peritoneal dialysis circuit includes two single-channel peritoneal dialysis catheters or one double-channel peritoneal dialysis catheter.

28. The peritoneal dialysis device according to claim 25, characterized in that The peritoneal dialysis device is configured as a CFPD mode, and the peritoneal dialysis catheter is configured as a dual-channel, wherein one channel is used to output dialysis waste fluid, and the other channel is used to input regeneration fluid.

29. A hemodialysis device, characterized in that: include: The dialysate regeneration system according to any one of claims 1 to 24; A purification circuit includes a first circuit having an input end connected to a first part of a human body, and a second circuit having an output end connected to a second part of a human body; A dialysis device, provided on the purification circuit, for purifying the fluid flowing in the purification circuit, the dialysis device comprising: a dialysis fluid output end connected to the input end of the waste fluid passage of the dialysis fluid regeneration system; and A dialysate input end connected to an output end of a regeneration fluid pipeline of the dialysate regeneration system; a driving device, provided on the first line and located in the purification circuit, for driving the fluid to flow in the purification circuit; The control device is used to execute a treatment mode to purify the fluid flowing in the purification circuit and then input it into the human body.

30. The hemodialysis device according to claim 29, characterized in that The dialysis device is a hemodialyzer or a hemodiafiltration device.

31. The hemodialysis device according to claim 29, characterized in that The hemodialysis equipment includes one or more treatment combinations of hemodialysis (HD), hemofiltration (HF), hemodiafiltration (HDF), hemoperfusion (HP), blood exchange (PE), immunoadsorption (IA), or continuous blood purification (CRRT).

32. The hemodialysis device according to claim 29, characterized in that It also includes at least one detection device for detecting the concentration of target molecules in the dialysis waste liquid, detecting the content of enzyme-loaded microspheres in the waste liquid passage, or detecting the content of enzyme-loaded microspheres in the regeneration liquid pipeline.

33. The hemodialysis device according to claim 29, characterized in that It also includes a mode selection device, which is used to receive an input mode selection signal and send the determined working mode information to the control device to execute the operation corresponding to the working mode.

34. The hemodialysis device according to claim 29, characterized in that The working mode of the hemodialysis device includes a combination of one or more treatment modes of HF treatment mode, HD treatment mode, HDF treatment mode, and ultrafiltration mode.

35. The hemodialysis device according to claim 34, characterized in that In the HF treatment mode, the control device controls the regeneration fluid output by the dialysate regeneration system to be directly input into the first line or the second line.

36. The hemodialysis device according to claim 34, characterized in that In the HD treatment mode, the control device controls the regeneration fluid output by the dialysate regeneration system to be input into the dialysate input end of the dialysis device.

37. The hemodialysis device according to claim 34, characterized in that In the HDF treatment mode, the control device controls the regeneration fluid output by the dialysate regeneration system to be input into the first circuit or the second circuit via a replacement fluid branch; The replacement fluid branch is arranged on the regeneration fluid pipeline, one end of the replacement fluid branch is connected to the regeneration fluid pipeline, and the other end is used to connect to the dialysis circuit.

38. The hemodialysis device according to claim 37, characterized in that In the HDF treatment mode, the control device adjusts the output of the substitution fluid branch by periodically and dynamically adjusting the fluid volume in the waste fluid passage, the reactor, or the regeneration fluid pipeline to control the molecular convection exchange volume of the dialysis device.

39. The hemodialysis device according to claim 37, characterized in that In the HDF treatment mode, the control device periodically changes the total amount of liquid equilibrium state of the dialysate circulation to periodically filter and filter out the liquid inside and outside the dialyzer.

40. The hemodialysis device according to claim 39, characterized in that In the HDF treatment mode, the total amount of liquid equilibrium state in the dialysate circulation is changed by adjusting the differential speed of two dialysate pumps, a dialysate pump in the waste liquid passage and a dialysate pump in the regeneration liquid pipeline.

41. The hemodialysis device according to claim 34, characterized in that In the ultrafiltration mode, the ultrafiltration branch in the dialysate regeneration system diverts the dialysate waste in the waste fluid passage to increase the transmembrane pressure or negative pressure, so that the dialysis device filters an equal amount of liquid from the blood or peritoneal fluid flowing through it into the dialysate waste, thereby achieving dehydration treatment.

42. The hemodialysis device according to claim 41, characterized in that In the ultrafiltration mode, the control device controls the rotation speed of the ultrafiltration pump or an empirical value to measure the flow rate of the dialysis waste fluid diverted by the ultrafiltration branch to the waste fluid passage.

43. The hemodialysis device according to claim 42, characterized in that In the ultrafiltration mode, the control device controls the rotation speed of the ultrafiltration pump by obtaining the volume or weight of the regeneration liquid in the regeneration liquid pipeline to measure the flow rate of the dialysis waste liquid in the waste liquid passage diverted by the ultrafiltration branch.

44. The hemodialysis device according to claim 43, characterized in that The volume or weight of the regeneration liquid is obtained by weighing or liquid level measurement.

Images