Solid-phase extraction device, system and control method

Abstract

The invention discloses a solid-phase extraction device and system and a control method, and belongs to the technical field of extraction.The solid-phase extraction device comprises an extraction column supporting mechanism, a positive pressure mechanism, a first vertical driving mechanism and a liquid receiving mechanism, the positive pressure mechanism is located above the extraction column supporting mechanism and comprises a switching assembly and a plurality of sealing parts connected to the switching assembly, and the first vertical driving mechanism is located above the extraction column supporting mechanism; an air channel is formed in the sealing piece in the axial direction of the sealing piece in a penetrating mode. The switching assembly communicates with the air source and the air channel of the sealing piece. The first vertical driving mechanism is connected with the positive pressure mechanism or the extraction column supporting mechanism and can drive the positive pressure mechanism or the extraction column supporting mechanism to move in the vertical direction so as to press the sealing element into the extraction column or pull the sealing element out of the extraction column; the liquid receiving mechanism is located below the extraction column supporting mechanism and can bear a plurality of sample bottles, the sample bottles and the extraction columns are arranged in a one-to-one correspondence mode, and the sample bottles contain extraction liquid discharged from the extraction columns. According to the technical scheme provided by the invention, the solid-phase extraction time can be shortened, and the solid-phase extraction efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the field of extraction technology, and in particular to a solid phase extraction device, system and control method. Background Art

[0002] Solid phase extraction is a sample pretreatment technology developed in recent years. It is developed by combining liquid-solid extraction columns and liquid chromatography technology. It is mainly used for sample separation, purification and concentration. Compared with traditional liquid-liquid extraction, it can improve the recovery rate of analytes, more effectively separate analytes from interfering components, reduce sample pretreatment processes, and is simple to operate, time-saving and labor-saving. It is widely used in the fields of medicine, food, environment, commodity inspection, chemical industry, etc.

[0003] In the prior art, extraction is usually performed under normal temperature and pressure, such as by standing the extraction, which results in a long extraction time and low extraction efficiency. Summary of the invention

[0004] The object of the present invention is to provide a solid phase extraction device, system and control method, which can shorten the solid phase extraction time and improve the solid phase extraction efficiency.

[0005] As conceived above, the technical solution adopted by the present invention is:

[0006] A solid phase extraction device, comprising:

[0007] An extraction column supporting mechanism, used for supporting a plurality of extraction columns;

[0008] A positive pressure mechanism is located above the extraction column support mechanism, the positive pressure mechanism comprises a transfer assembly and a plurality of seals connected to the transfer assembly, the seals are arranged one by one with the extraction columns, an air passage is opened through the seal along the axial direction of the seal, and the transfer assembly is used to connect the air source with the air passage of the seal;

[0009] a first vertical driving mechanism, connected to the positive pressure mechanism or the extraction column supporting mechanism, and used to drive the positive pressure mechanism or the extraction column supporting mechanism to move in a vertical direction so as to press the sealing member into the extraction column or pull the sealing member out of the extraction column;

[0010] The liquid receiving mechanism is located below the extraction column supporting mechanism and is used to carry a plurality of sample bottles. The sample bottles are arranged in a one-to-one correspondence with the extraction columns and are used to receive the extraction liquid discharged from the extraction columns.

[0011] Optionally, the first vertical drive mechanism is detachably connected to the positive pressure mechanism; the solid phase extraction device also includes a quick-change assembly, the quick-change assembly includes a first quick-change connector and a second quick-change connector that are detachably connected, the first vertical drive mechanism is connected to the first quick-change connector, and the adapter assembly is connected to the second quick-change connector.

[0012] Optionally, the first quick-change joint is provided with a first air inlet and a first air outlet, a first air path is formed between the first air inlet and the first air outlet, and the second quick-change joint is provided with a second air inlet and a second air outlet, a second air path is formed between the second air inlet and the second air outlet;

[0013] The first air inlet is communicated with the air source, and the second air outlet is communicated with the adapter assembly; when the first quick-change connector is connected to the second quick-change connector, the first air path is communicated with the second air path.

[0014] Optionally, the adapter assembly has a confluence cavity connected to the gas source, the adapter assembly includes a confluence plate and a fixing plate connected to each other, the confluence plate has a confluence groove on the surface facing the fixing plate, the fixing plate covers the opening of the confluence groove and forms the confluence cavity with the confluence groove, the fixing plate has a plurality of mounting holes connected to the confluence cavity, the sealing members are sealingly mounted in the mounting holes one by one, and the second quick-change connector is connected to the confluence plate;

[0015] The confluence plate is provided with a vent hole, one end of the vent hole is communicated with the second air outlet of the second quick-change connector, and the other end of the vent hole is communicated with the confluence cavity.

[0016] Optionally, the adapter assembly further includes a flow stabilizing plate connected to the confluence plate, the flow stabilizing plate is located in the confluence cavity and divides the confluence cavity into two upper and lower air cavities, and the flow stabilizing plate has a plurality of flow stabilizing holes that are arranged at intervals and can connect the two air cavities.

[0017] Optionally, the first vertical driving mechanism is connected to the positive pressure mechanism, and the solid phase extraction device further comprises a second vertical driving mechanism, which is connected to the extraction column supporting mechanism and is used to drive the extraction column supporting mechanism to move in a vertical direction.

[0018] Optionally, it also includes:

[0019] a first horizontal driving mechanism, connected to the first vertical driving mechanism, the first horizontal driving mechanism being used to drive the first vertical driving mechanism to move in a horizontal direction; and / or

[0020] The second horizontal driving mechanism is connected to the liquid contacting mechanism, and is used to drive the liquid contacting mechanism to move in a horizontal direction.

[0021] Optionally, a waste liquid tank is further included, and the waste liquid tank is connected to the second horizontal driving mechanism, and the second horizontal driving mechanism can drive the sample bottle or the waste liquid tank carried by the liquid receiving mechanism to move to the bottom of the extraction column.

[0022] Optionally, the seal includes a connecting portion, a main body and a sealing skirt, the connecting portion is connected to the main body, the connecting portion is used for sealing connection with the adapter assembly, and the sealing skirt is connected to an end of the main body facing away from the connecting portion; the sealing skirt is arranged around the periphery of the main body, and when the first vertical driving mechanism presses the seal into the extraction column, the sealing skirt can be in sealing contact with the inner wall of the extraction column.

[0023] Optionally, the first end of the sealing skirt is connected to the main body, the second end of the sealing skirt extends toward the connecting portion, and the diameter of the sealing skirt gradually increases from the first end to the second end.

[0024] Optionally, the extraction column support mechanism comprises a first support platform and an extraction column tray, the first support platform is used to support the extraction column tray; the extraction column tray comprises an extraction column cover plate, an extraction column support plate, a support column and a tray bottom plate, the tray bottom plate is connected to the extraction column support plate through the support column, the tray bottom plate and the extraction column support plate are correspondingly provided with a plurality of first through holes for the extraction columns to pass through, the extraction column cover plate is correspondingly provided with a plurality of second through holes for the sealing member to pass through, the extraction column cover plate is provided on the extraction column support plate to limit the movement of the extraction column relative to the extraction column support plate in the vertical direction;

[0025] The first supporting platform is provided with a first positioning member, and the first positioning member is used to limit the extraction column tray to the first supporting platform.

[0026] Optionally, the liquid receiving mechanism includes a second supporting platform and a sample receiving tray, the second supporting platform is used to support the sample receiving tray, the sample receiving tray is provided with a plurality of placement holes for placing the sample bottles; a second positioning member is provided on the second supporting platform, the second positioning member is used to limit the sample receiving tray to the second supporting platform.

[0027] Optionally, it also includes a flow control valve and a switch valve, one end of the flow control valve is connected to the gas source, the other end of the flow control valve is connected to the switch valve, the other end of the switch valve is connected to the adapter assembly, the flow control valve is used to adjust the size of the airflow flowing to the adapter assembly, and the switch valve is used to control the on-off of the air path flowing to the adapter assembly.

[0028] Optionally, the switch valve is a two-position three-way solenoid valve, which includes a first interface, a second interface and a third interface. The first interface is connected to the flow control valve, the second interface is connected to the adapter assembly, and the third interface is used to discharge the gas in the extraction column when the seal is pressed into the extraction column.

[0029] A solid phase extraction system comprises a transport device and the solid phase extraction device as described above, wherein the transport device is used to load and unload a positive pressure mechanism from the solid phase extraction device, and / or to take and place an extraction column from the solid phase extraction device, and / or to take and place a sample bottle from the solid phase extraction device.

[0030] Optionally, a liquid adding device is further included, and the liquid adding device is used to inject the solution to be extracted into the extraction column of the solid phase extraction device.

[0031] A control method for a solid phase extraction device, used to control the solid phase extraction device as described above, the control method comprising the following steps:

[0032] Supporting a plurality of extraction columns containing solutions to be extracted on an extraction column supporting mechanism;

[0033] Placing a plurality of sample bottles on the liquid receiving mechanism, and arranging the sample bottles and the extraction columns in a one-to-one correspondence;

[0034] Controlling the first vertical driving mechanism to drive the positive pressure mechanism to move in the vertical direction so that the sealing member is pressed into the corresponding extraction column;

[0035] Opening the gas source so that the gas source injects gas into the extraction column through the adapter assembly and the air passage of the sealing member;

[0036] After the extraction is completed, the first vertical driving mechanism is controlled to drive the positive pressure mechanism to move in the reverse direction to pull the sealing member out of the extraction column.

[0037] Beneficial effects of the present invention:

[0038] The solid phase extraction device, system and control method provided by the present invention support the extraction column through an extraction column supporting mechanism, the adapter assembly can connect the gas source and the airway of the seal, multiple seals correspond to multiple extraction columns one by one, and each seal can be pressed into and seal the extraction column corresponding to it under the drive of the first vertical drive mechanism, the gas provided by the gas source flows into the extraction column through the adapter assembly and the airway, so that the gas pressure in each extraction column is increased, thereby realizing simultaneous and rapid extraction of multiple extraction columns, and the extract extracted by each extraction column can be received by the corresponding sample bottle, which reduces the time required for extraction and improves the extraction efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 is a schematic structural diagram of a solid phase extraction device provided in Example 1 of the present invention;

[0040] Figure 2 is a rear view of the solid phase extraction device provided in the first embodiment of the present invention;

[0041] Figure 3 It is an assembly diagram of the first vertical drive mechanism, the positive pressure mechanism and the quick-change assembly provided in the first embodiment of the present invention;

[0042] Figure 4 Embodiment of the present invention Figure 3 a front view of the structure shown;

[0043] Figure 5 It is a schematic diagram of the assembly of the positive pressure mechanism and the second quick-change connector provided in the first embodiment of the present invention;

[0044] Figure 6 Embodiment of the present invention Figure 5 a top view of the structure shown;

[0045] Figure 7 Embodiment of the present invention Figure 6 AA section view shown;

[0046] Figure 8 is a schematic structural diagram of a sealing member provided in Embodiment 1 of the present invention;

[0047] Fig. 9 is a cross-sectional schematic diagram of a sealing member provided in Embodiment 1 of the present invention;

[0048] Fig.10 is a schematic diagram of the sealing member provided in the first embodiment of the present invention being pressed into the extraction column;

[0049] Fig.11 Embodiment of the present invention Fig.10 BB section view shown;

[0050] Fig.12It is a schematic diagram of the assembly of the extraction column support mechanism and the second vertical drive mechanism provided in the first embodiment of the present invention;

[0051] Fig.13 is a schematic structural diagram of an extraction column tray provided in Embodiment 1 of the present invention;

[0052] Fig.14 It is a schematic diagram of the assembly of the liquid receiving mechanism, the second horizontal driving mechanism and the waste liquid tank provided in the first embodiment of the present invention;

[0053] Fig.15 is a structural schematic diagram of a first horizontal driving mechanism provided in Embodiment 1 of the present invention;

[0054] Fig.16 It is a flow chart of the control method of the solid phase extraction device provided in the second embodiment of the present invention.

[0055] In the figure:

[0056] 1. Extraction column support mechanism; 11. First support platform; 12. Extraction column tray; 121. Extraction column cover plate; 122. Extraction column support plate; 123. Support column; 124. Tray bottom plate; 2. Positive pressure mechanism; 21. Adapter assembly; 211. Manifold chamber; 212. Manifold plate; 213. Fixing plate; 214. Sealing ring; 22. Sealing member; 220. Main body; 221. Airway; 222. Connecting part; 223. Sealing piston; 2 3. Flow stabilizer; 3. First horizontal drive mechanism; 31. Second drive member; 4. First vertical drive mechanism; 40. First drive member; 41. First motor fixing plate; 42. First sensor; 43. First sensor sheet; 44. Connector fixing plate; 45. Drag chain; 46. First slider; 47. First guide rail; 48. First connecting plate; 5. Quick-change assembly; 51. First quick-change connector; 52. Second quick-change connector; 6. Quick-change on / off connector; 7. Second vertical drive mechanism; 70, third connecting plate; 71, third driving member; 72, third motor fixing plate; 73, third sensor; 74, third sensor sheet; 75, third guide rail; 76, third slider; 8, liquid receiving mechanism; 81, supporting bottom plate; 82, second supporting platform; 84, sample receiving tray; 85, waste liquid tank; 80, second horizontal drive mechanism; 83, fourth driving member; 86, fourth guide rail; 87, fourth sensor; 88, fourth sensor sheet; 89, second push block; 9, support frame; 91, second connecting plate; 92, second motor fixing plate; 93, first push block; 94, second sensor; 95, second sensor sheet; 96, second slider; 97, second guide rail; 10, electric control component; 101, controller; 102, switch valve; 103, electrical backplane; 104, communication adapter board; 105, flow control valve; 100, extraction column; 200, sample bottle. DETAILED DESCRIPTION

[0057] In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved clearer, the technical solutions of the present invention are further described below in conjunction with the accompanying drawings and through specific implementation methods. It is understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for the convenience of description, only the parts related to the present invention are shown in the accompanying drawings, not all.

[0058] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0059] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0060] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0061] In the description of this embodiment, the terms "upper", "lower", "right", etc., directions or positional relationships are based on the directions or positional relationships shown in the drawings, and are only for the convenience of description and simplification of operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0062] Embodiment 1

[0063] This embodiment provides a solid phase extraction device, which can shorten the solid phase extraction time and improve the solid phase extraction efficiency.

[0064] like Figure 1 and Figure 2 As shown, the solid phase extraction device includes an extraction column supporting mechanism 1, a positive pressure mechanism 2, a first vertical driving mechanism 4 and a liquid receiving mechanism 8.

[0065] The extraction column support mechanism 1 is used to support a plurality of extraction columns 100, each of which can realize solid phase extraction. The positive pressure mechanism 2 is arranged above the extraction column support mechanism 1. In addition, the positive pressure mechanism 2 includes an adapter assembly 21 and a plurality of seals 22 connected to the adapter assembly 21. The plurality of seals 22 are arranged one by one corresponding to the plurality of extraction columns 100, and each seal 22 can be pressed into the corresponding extraction column 100, so that each seal 22 can seal the corresponding extraction column 100.

[0066] like Fig. 9 As shown, each seal 22 is provided with an air passage 221 along the axial direction of the seal 22, and the adapter assembly 21 is used to connect the gas source with the air passage 221 of each seal 22, so that gas can be injected into the multiple extraction columns 100 through the adapter assembly 21 and the multiple seals 22, thereby gradually increasing the pressure in the extraction column 100, realizing pressurized extraction, and accelerating the extraction rate.

[0067] The first vertical drive mechanism 4 is connected to the positive pressure mechanism 2 or the extraction column support mechanism 1, and is used to drive the positive pressure mechanism 2 or the extraction column support mechanism 1 to move in the vertical direction, so as to press the seal 22 into the corresponding extraction column 100 or pull the seal 22 out of the extraction column 100, thereby realizing the automatic pressing and pulling out of the seal 22, and improving the efficiency of the extraction process. In some optional embodiments, the extraction column support mechanism 1 is stationary in the vertical direction, and the first vertical drive mechanism 4 drives the positive pressure mechanism 2 to move closer to or away from the extraction column support mechanism 1. In some other optional embodiments, the positive pressure mechanism 2 is stationary in the vertical direction, and the first vertical drive mechanism 4 drives the extraction column support mechanism 1 to move closer to or away from the positive pressure mechanism 2. It should be noted that the first vertical drive mechanism 4 and the positive pressure mechanism 2 can be fixedly connected or detachably connected, and the first vertical drive mechanism 4 and the extraction column support mechanism 1 can also be fixedly connected or detachably connected, which is not limited in this embodiment.

[0068] The liquid receiving mechanism 8 is located below the extraction column supporting mechanism 1 and is used to carry a plurality of sample bottles 200 . The plurality of sample bottles 200 are arranged in one-to-one correspondence with the plurality of extraction columns 100 , and each sample bottle 200 can receive the extraction liquid discharged from the extraction column 100 .

[0069] When using the solid phase extraction device provided in this embodiment, a plurality of empty extraction columns 100 are placed on the extraction column support mechanism 1, and then the solution to be extracted is injected into each extraction column 100; then, a plurality of sample bottles 200 are placed one by one under the plurality of extraction columns 100, so that the extract dripped from the extraction columns 100 can fall into the corresponding sample bottles 200; next, the axis of each sealing member 22 is controlled to coincide with the axis of the corresponding extraction column 100; then, the positive pressure mechanism 2 is driven downward or the extraction column support mechanism 1 is driven upward by the first vertical driving mechanism 4, thereby pushing the sealing member 22 to move downward. 22 and the extraction column 100 are close to each other until the sealing member 22 is pressed into the corresponding extraction column 100 and seals the corresponding extraction column 100; next, the gas source injects gas into the extraction column 100 through the air passage 221 of the adapter assembly 21 and the sealing member 22, so that the gas pressure in the extraction column 100 increases and squeezes the liquid in the extraction column 100, so that the solution to be extracted is extracted through the corresponding filler inside the extraction column 100 to obtain the extract, which flows out through the outlet at the bottom of the extraction column 100 and can directly drip into the corresponding sample bottle 200, and then be collected by the sample bottle 200. In some embodiments, the specific structure of the extraction column 100 can refer to the prior art, and the sample bottle 200 can be a container such as a test tube, a reagent bottle, etc. Among them, the gas provided by the gas source can be an inert gas that is not easy to react chemically with the solution, such as helium, nitrogen, etc.

[0070] The solid phase extraction device provided in this embodiment supports the extraction column 100 through the extraction column support mechanism 1, the adapter component 21 can connect the gas source and the air channel 221 of the seal 22, and multiple seals 22 correspond to multiple extraction columns 100 one by one. Under the drive of the first vertical drive mechanism 4, each seal 22 can be pressed into and seal the corresponding extraction column 100. The gas provided by the gas source flows into the extraction column 100 through the adapter component 21 and the air channel 221, so that the gas pressure in each extraction column 100 is increased, thereby realizing simultaneous and rapid extraction of multiple extraction columns 100, and the extract extracted by each extraction column 100 can be received by the corresponding sample bottle 200, which reduces the time required for extraction and improves the extraction efficiency.

[0071] In some optional embodiments, the first vertical driving mechanism 4 is detachably connected to the positive pressure mechanism 2, such as Figure 1 As shown, the solid phase extraction device further includes a quick-change assembly 5, and the first vertical drive mechanism 4 is detachably connected to the positive pressure mechanism 2 via the quick-change assembly 5. Specifically, as Figure 3 and Figure 4As shown, the quick-change assembly 5 includes a first quick-change connector 51 and a second quick-change connector 52 that are detachably connected. It should be noted that the disassembly and installation between the first quick-change connector 51 and the second quick-change connector 52 can be achieved through an external handling device (such as a mechanical arm, a mobile robot, etc.). The output end of the first vertical drive mechanism 4 is connected to the first quick-change connector 51, and the adapter assembly 21 is connected to the second quick-change connector 52, so that the connection and separation between the first vertical drive mechanism 4 and the adapter assembly 21 can be achieved by a machine, which improves the automation of the installation and disassembly of the solid phase extraction device, and has high assembly efficiency and assembly accuracy. In addition, the positive pressure mechanism 2 is quickly connected and disassembled with the first vertical drive mechanism 4 through the quick-change assembly 5, which can achieve rapid installation and replacement of the positive pressure mechanism 2.

[0072] The first quick-change connector 51 and the second quick-change connector 52 can be connected and disconnected by pneumatic means, magnetic means, hydraulic means, latch means, screw means, etc., which are not limited here. For example, the first quick-change connector 51 can be a quick-change male connector, and the second quick-change connector 52 can be a quick-change female connector.

[0073] Optionally, the first quick-change connector 51 is provided with a first air inlet and a first air outlet, a first air path is formed between the first air inlet and the first air outlet, and the second quick-change connector 52 is provided with a second air inlet and a second air outlet, a second air path is formed between the second air inlet and the second air outlet. The first air inlet is connected to the air source, and the second air outlet is connected to the adapter assembly 21; and when the first quick-change connector 51 is connected to the second quick-change connector 52, the first air path is connected to the second air path, so that the gas in the air source can flow into the first air path through the first air inlet, and flow out of the first air path from the first air outlet, so as to enter the second air path through the second air inlet, flow out from the second air outlet and flow to the adapter assembly 21. Optionally, the first air inlet can be provided on the side wall of the first quick-change connector 51, and the first air outlet can be provided on the end face of the first quick-change connector 51 facing the second quick-change connector 52, so as to have a larger flow area. The second air inlet can be arranged on the end surface of the second quick-change connector 52 facing the first quick-change connector 51 to better connect with the first air outlet. The second air outlet can be arranged on the side wall of the second quick-change connector 52 or on the end surface of the second quick-change connector 52 facing the adapter assembly 21.

[0074] For example, Figure 3As shown, a quick-change on-off connector 6 is provided on the first quick-change connector 51. The quick-change on-off connector 6 is used to connect to an external gas source so that the first quick-change connector 51 and the second quick-change connector 52 can be connected and disconnected through the internal gas path. The specific implementation method of the quick-change connection and disconnection between the first quick-change connector 51 and the second quick-change connector 52 can refer to the prior art and will not be described here. Among them, the gas path used for connection and disconnection between the first quick-change connector 51 and the second quick-change connector 52 can be separated from the gas path of the adapter assembly 21 that cooperates with the two and is not interconnected, so as to ensure that the connection of the two quick-change connectors will not be affected when the pressurized extraction is stopped.

[0075] Alternatively, if Figure 3 and Figure 4 As shown, the first vertical drive mechanism 4 includes a first drive member 40, a first motor fixing plate 41, a joint fixing plate 44, a first slider 46, a first guide rail 47 and a first connecting plate 48. The first drive member 40 is exemplified by a drive component such as a screw motor and a cylinder. The first drive member 40 is mounted on the first motor fixing plate 41, and the first motor fixing plate 41 is mounted on the first connecting plate 48. The first guide rail 47 is fixedly mounted on the first connecting plate 48, and the first slider 46 is slidably arranged on the first guide rail 47. The joint fixing plate 44 is fixedly connected to the first slider 46, and the first quick-change joint 51 or the adapter assembly 21 is connected to the bottom surface of the joint fixing plate 44. The output end of the first drive member 40 is connected to the first slider 46 to drive the first slider 46 to move on the first guide rail 47, and drive the joint fixing plate 44 and the adapter assembly 21 to move in the vertical direction to approach the extraction column 100 or move away from the extraction column 100.

[0076] Optionally, the first vertical drive mechanism 4 may further include a first sensor 42 and a first sensor sheet 43, wherein the first sensor 42 is mounted on the first motor fixing plate 41, and the first sensor sheet 43 is mounted on the first slider 46. The first sensor 42 can sense the position of the first sensor sheet 43, thereby sensing the position of the first slider 46 to prevent the first slider 46 from moving excessively, thereby facilitating the control of the first slider 46 to return to an initial position (such as returning the first drive member 40 to zero) or move to a specific position (such as pressing the seal 22 into a specified depth of the extraction column 100).

[0077] Optionally, the first vertical driving mechanism 4 may further include a drag chain 45, one end of which is connected to the first connecting plate 48, and the other end is connected to the joint fixing plate 44, and the first connecting plate 48 and the joint fixing plate 44 in this embodiment are respectively provided with a fixed sheet metal for connecting the drag chain 45. The drag chain 45 can be used to accommodate various cables and air pipes, which can store, pull and protect the built-in cables and air pipes, and can also enhance the overall aesthetics of the device.

[0078] Optionally, the solid phase extraction device may further include a first horizontal driving mechanism 3 connected to the first vertical driving mechanism 4, wherein the first horizontal driving mechanism 3 is used to drive the first vertical driving mechanism 4 to move horizontally, so as to drive the positive pressure mechanism 2 or the extraction column support mechanism 1 connected to the first vertical driving mechanism 4 to move horizontally, so that the seal 22 can face the extraction column 100 in the vertical direction, and then each seal 22 can be smoothly pressed into the corresponding extraction column 100, and the seal 22 and the extraction column 100 can be staggered in the horizontal direction to facilitate the removal and placement of the positive pressure mechanism 2 and the extraction column 100.

[0079] For example, Fig.15 As shown, the first horizontal driving mechanism 3 includes a second driving member 31, a second connecting plate 91, a second motor fixing plate 92, a first pushing block 93, a second slider 96 and a second guide rail 97, wherein the second motor fixing plate 92 is fixed on the second connecting plate 91, the second driving member 31 is fixed on the second motor fixing plate 92, the output end of the second driving member 31 is connected to the first pushing block 93, the first connecting plate 48 is connected to the second slider 96, the second guide rail 97 is arranged on the second connecting plate 91, and the second guide rail 97 and the second motor fixing plate 92 are respectively located on both sides of the second connecting plate 91. The second slider 96 is slidably arranged on the second guide rail 97, and the first pushing block 93 passes through the second connecting plate 91 and is connected to the second slider 96. Among them, the second driving member 31 can be a driving component such as a screw motor and a cylinder.

[0080] Furthermore, the first horizontal driving mechanism 3 may also include a second sensor 94 and a second sensor sheet 95. The second sensor sheet 95 is disposed on the first push block 93, and the second sensor 94 is disposed on the second connecting plate 91 and is disposed opposite to the second sensor sheet 95. Thus, the position of the first push block 93 is sensed, and the first push block 93 is prevented from being excessively moved, so as to control the first push block 93 to return to the initial position (such as returning the second driving member 31 to zero) or to move to a specific position (such as a position where the seal 22 and the extraction column 100 are staggered in the horizontal direction or a position where the seal 22 and the extraction column 100 are facing each other in the vertical direction).

[0081] Optionally, see Figures 5 to 7, the adapter assembly 21 has a confluence chamber 211 connected to the gas source. More specifically, the adapter assembly 21 includes a confluence plate 212 and a fixed plate 213 connected to each other, and the confluence plate 212 is arranged in parallel with the fixed plate 213. The surface of the confluence plate 212 facing the fixed plate 213 has a confluence groove, and the fixed plate 213 covers the opening of the confluence groove and forms the above-mentioned confluence chamber 211 with the confluence groove. The fixed plate 213 has a plurality of mounting holes connected to the confluence chamber 211, and a plurality of sealing members 22 are sealed and installed in the plurality of mounting holes in a one-to-one correspondence. In some embodiments, a sealing structure is provided between the sealing member 22 and the hole wall of the mounting hole. In other embodiments, a sealing ring 214 is provided between the confluence plate 212 and the fixed plate 213, so that a sealed connection is formed between the confluence plate 212 and the fixed plate 213. The confluence plate 212 and the fixed plate 213 can be fixed by screwing, gluing, welding, etc.

[0082] In this embodiment, the second quick-change connector 52 is connected to the manifold 212. In addition, the manifold 212 is provided with a vent hole, one end of which is connected to the second gas outlet of the second quick-change connector 52, and the other end of which is connected to the manifold cavity 211, so that the gas flowing out of the second quick-change connector 52 can flow into the manifold cavity 211 through the vent hole.

[0083] Furthermore, the second quick-change connector 52 is located on the side of the manifold 212 facing away from the fixed plate 213, and the second quick-change connector 52 is connected to the geometric center of the manifold 212, so that the force applied by the adapter assembly 21 on the multiple seals 22 can be relatively uniform, preventing the seals 22 from being subjected to uneven force, and facilitating the successful pressing of the seals 22 into the corresponding extraction column 100, and the pressing depth remains basically consistent. It should be noted that the manifold 212 in this embodiment is in the shape of a rectangular parallelepiped, the second quick-change connector 52 is in the shape of a cylinder, and the axis of the manifold 212 coincides with the axis of the second quick-change connector 52.

[0084] Furthermore, if Figure 7 As shown, the adapter assembly 21 also includes a flow stabilizing plate 23 connected to the confluence plate 212. The flow stabilizing plate 23 is located in the confluence chamber 211 and divides the confluence chamber 211 into two upper and lower air chambers. The flow stabilizing plate 23 has a plurality of flow stabilizing holes arranged at intervals, and the flow stabilizing holes can connect the two air chambers. The gas introduced by the vent hole can enter one air chamber, and flow to another air chamber after being diverted by the plurality of flow stabilizing holes, so as to adjust the distribution of the gas in the confluence chamber 211, so that the amount of gas injected into the plurality of extraction columns 100 can be more balanced, so that the extraction speeds of the extraction columns 100 can be equal, and it can also prevent some extraction columns 100 from being damaged due to excessive internal air pressure.

[0085] The seal 22 has various structures. This embodiment provides a seal 22 such as Figure 8 and Fig. 9As shown, the sealing member 22 includes a main body 220, a connecting portion 222 and a sealing skirt 223, wherein the connecting portion 222 is connected to the main body 220, the connecting portion 222 is used for sealing connection with the adapter assembly 21, and the sealing skirt 223 is connected to one end of the main body 220 away from the connecting portion 222; the sealing skirt 223 is arranged around the outer periphery of the main body 220, and when the first vertical driving mechanism 4 presses the sealing member 22 into the extraction column 100, the sealing skirt 223 can be in sealing contact with the inner wall of the extraction column 100. It should be noted that the main body 220 of the sealing member 22 is columnar, and the diameter of the main body 220 is smaller than the inner diameter of the extraction column 100. In some embodiments, the connecting portion 222 has a thread, and the connecting portion 222 is screwed into the mounting hole of the fixing plate 213 through the thread. The sealing skirt 223 is annularly arranged outside the main body 220 of the sealing member 22, and the diameter of at least a part of the structure of the sealing skirt 223 is slightly larger than the inner diameter of the extraction column 100, so as to achieve a sealed connection with the extraction column 100 by interference fit. In this embodiment, the main body 220 of the sealing member 22 is also provided with a clamping plane, which is convenient for an auxiliary tool (such as a wrench) to clamp when tightening or loosening the sealing member 22 and the mounting hole of the fixing plate 213, so as to prevent the auxiliary tool and the sealing member 22 from sliding relative to each other.

[0086] In some embodiments, one end of the main body 220 close to the connecting portion 222 is set as a step structure, and the step structure can be used to limit the connecting portion 222 when the connecting portion 222 is connected to the mounting hole of the fixing plate 213 to avoid the connecting portion 222 from tilting during installation, thereby affecting the subsequent docking accuracy between the sealing part 22 and the extraction column 100.

[0087] In some optional embodiments, the sealing skirt 223 has a first end and a second end opposite to each other, the first end of the sealing skirt 223 is connected to the main body 220, the second end of the sealing skirt 223 extends toward the direction of the connecting portion 222, and the diameter of the sealing skirt 223 gradually increases from the first end to the second end, so that the second end of the sealing skirt 223 can be close to the inner wall of the extraction column 100 to achieve a sealing effect, which can be understood as the sealing skirt 223 and the side wall of the main body 220 are arranged at an angle. In addition, the setting of the sealing skirt 223 being wide at the top and narrow at the bottom can guide the sealing member 22 when it is pressed into the extraction column 100, so as to facilitate the faster pressing of the sealing member 22. In some embodiments, the sealing member 22 is an integrally formed structure, which can be formed by injection molding or the like.

[0088] like Fig. 9 As shown, the axis of the air passage 221 coincides with the axis of the sealing member 22 . Fig.10 The state when the sealing member 22 is pressed into the extraction column 100 is shown in FIG. Fig.10 and Fig.11As shown, the axis of the airway 221, the axis of the seal 22 and the axis of the extraction column 100 coincide, so as to prevent the seal 22 from tilting when pressed in, and thus having high reliability. The sealing skirt 223 is deformed when pressed into the extraction column 100, so as to tightly abut against the inner wall of the extraction column 100, thereby achieving a seal between the seal 22 and the extraction column 100. The sealing skirt 223 can be made of elastic materials such as rubber and silicone.

[0089] In some optional embodiments, when the first vertical driving mechanism 4 is connected to the positive pressure mechanism 2, as Fig.12 As shown, the solid phase extraction device may further include a second vertical driving mechanism 7. The second vertical driving mechanism 7 is connected to the extraction column support mechanism 1 and is used to drive the extraction column support mechanism 1 to move in the vertical direction to achieve the lifting and lowering of the extraction column support mechanism 1, thereby enabling the extraction column support mechanism 1 to adapt to extraction columns 100 with different heights, thereby improving the versatility of the solid phase extraction device.

[0090] Alternatively, if Fig.12 As shown, the second vertical driving mechanism 7 includes a third connecting plate 70, a third driving member 71, a third motor fixing plate 72, a third guide rail 75 and a third slider 76. The third motor fixing plate 72 is fixed on the third connecting plate 70, the third driving member 71 is fixed on the third motor fixing plate 72, the third guide rail 75 is arranged on the third connecting plate 70, and the third slider 76 is slidably arranged on the third guide rail 75. The third driving member 71 can be a driving component such as a screw motor and a cylinder. The third slider 76 is connected to the extraction column support mechanism 1, so that when the third driving member 71 drives the third slider 76 to move, the extraction column support mechanism 1 is driven to move in the vertical direction to adjust the vertical spacing of the extraction column 100 relative to the sealing member 22 and the sample bottle 200.

[0091] Optionally, the second vertical driving mechanism 7 may further include a third sensor 73 and a third sensor sheet 74. The third sensor 73 is disposed on the third motor fixing plate 72, and the third sensor sheet 74 is disposed on the third slider 76 and is opposite to the third sensor 73. The third sensor 73 can sense the position of the third sensor sheet 74, thereby sensing the position of the third slider 76, thereby preventing the third slider 76 from moving excessively, and facilitating the control of the third slider 76 to return to the initial position (such as returning the third driving member 71 to zero) or move to a specific position (such as bringing the extraction column 100 close to the sample bottle 200).

[0092] like Fig.12As shown, the extraction column support mechanism 1 includes a first support platform 11 and an extraction column tray 12, and the first support platform 11 is used to support the extraction column tray 12. Optionally, the first support platform 11 is connected to the third slider 76, and the third slider 76 and the first support platform 11 can be arranged on both sides of the third connecting plate 70 to prevent mutual interference.

[0093] Alternatively, if Fig.13 As shown, the extraction column tray 12 includes an extraction column cover plate 121, an extraction column support plate 122, a support column 123 and a tray bottom plate 124. Among them, the tray bottom plate 124 is connected to the extraction column support plate 122 through the support column 123. The tray bottom plate 124 and the extraction column support plate 122 are correspondingly provided with a plurality of first through holes for the extraction column 100 to pass through, and the extraction column cover plate 121 is correspondingly provided with a plurality of second through holes for the sealing member 22 to pass through. The extraction column cover plate 121 is covered on the extraction column support plate 122 and is used to limit the movement of the extraction column 100 relative to the extraction column support plate 122 in the vertical direction.

[0094] In this embodiment, the extraction column cover plate 121 and the extraction column support plate 122 can cooperate with each other to limit the top of the extraction column 100, so that when the seal 22 is pulled out of the extraction column 100, the extraction column cover plate 121 can press the extraction column 100 to prevent the extraction column 100 from being lifted. In some embodiments, the top of the extraction column 100 is provided with a rib, and when the extraction column 100 is placed on the extraction column tray 12, the rib abuts against the edge of the first through hole of the extraction column support plate 122, and the bottom end of the extraction column 100 passes through the first through hole of the tray bottom plate 124 and faces the sample bottle 200. The rib abuts against the upper surface of the extraction column support plate 122, which can limit the extraction column 100 from moving downward relative to the extraction column support plate 122, and the extraction column cover plate 121 is covered on the top of the extraction column 100, which can limit the extraction column 100 from moving upward relative to the extraction column support plate 122. In addition, the above arrangement can also prevent the extraction column 100 from shaking and improve the stability of the structure.

[0095] In some optional embodiments, a first positioning member is provided on the first supporting platform 11, and the first positioning member is used to limit the extraction column tray 12 on the first supporting platform 11. The first positioning member is preferably two pins, and two pin holes are correspondingly provided on the tray bottom plate 124, and the two cooperate to realize the positioning of the extraction column tray 12 on the first supporting platform 11, so that the two can be loaded and unloaded and connected. In addition, the provision of the first positioning member is also conducive to ensuring the consistency of the position each time when the external handling device takes and places the extraction column tray 12. Of course, it can be understood that the first positioning member can also be a positioning hole, a groove, a magnetic member, a buckle, etc., and the first positioning member can also be a combination of the above situations, which is not limited in this embodiment. By providing the first positioning member, not only can the extraction column tray 12 be limited, but also the entire extraction column tray 12 can be prevented from being lifted up when the seal 22 is pulled out of the extraction column 100, thereby improving the stability of the device.

[0096] Alternatively, if Fig.14 As shown, the liquid receiving mechanism 8 includes a second support platform 82 and a sample receiving tray 84. The second support platform 82 is used to support the sample receiving tray 84, and the sample receiving tray 84 is provided with a plurality of placement holes for placing the sample bottle 200, so as to limit the sample bottle 200 in the radial direction of the sample bottle 200. A second positioning member is provided on the second support platform 82, and the second positioning member is used to limit the sample receiving tray 84 on the second support platform 82. The second positioning member is preferably two pins, and two pin holes are correspondingly provided on the second support platform 82. The two cooperate to realize the positioning of the sample receiving tray 84 on the second support platform 82, so that the two can be loaded and unloaded and connected; in addition, the second positioning member is also provided to ensure the consistency of the position each time when the external handling device takes and places the sample receiving tray 84; of course, it can be understood that the second positioning member can also be a positioning hole, a groove, a magnetic member, a buckle, etc., and the first positioning member can also be a combination of the above several situations, which is not limited in this embodiment.

[0097] Please continue to see Fig.14 The solid phase extraction device also includes a second horizontal driving mechanism 80, which is connected to the liquid receiving mechanism 8, and the second horizontal driving mechanism 80 is used to drive the liquid receiving mechanism 8 to move in the horizontal direction. In one embodiment, the second horizontal driving mechanism 80 is connected to the second supporting platform 82 of the liquid receiving mechanism 8, and is used to drive the second supporting platform 82 to move in the horizontal direction, so that the sample bottle 200 can be moved to the bottom of the extraction column 100. By arranging the liquid receiving mechanism 8 on the second horizontal driving mechanism 80, the liquid receiving mechanism 8 can be switched between the liquid receiving position and the pick-up and placement position, thereby increasing the flexibility of the device. In one embodiment, the solid phase extraction device also includes a supporting bottom plate 81, and the second horizontal driving mechanism 80 is arranged on the supporting bottom plate 81; wherein the second supporting platform 82 can be slidably arranged on the supporting bottom plate 81.

[0098] Furthermore, the solid phase extraction device further includes a waste liquid tank 85, which is connected to the second horizontal driving mechanism 80. The second horizontal driving mechanism 80 can drive the sample bottle 200 or the waste liquid tank 85 carried by the liquid receiving mechanism 8 to move to the bottom of the extraction column 100. When the sample bottle 200 is located below the extraction column 100, the extracted extract can be collected. When the waste liquid tank 85 moves to the bottom of the extraction column 100, it can collect unnecessary extract. In this embodiment, the waste liquid tank 85 is fixed on the second supporting platform 82 and is spaced apart from the sample receiving tray 84.

[0099] Optionally, see Fig.14 , the second horizontal driving mechanism 80 includes a fourth driving member 83, a fourth guide rail 86 and a second pushing block 89. Among them, the fourth guide rail 86 is arranged on the supporting bottom plate 81, and the second supporting platform 82 is slidably arranged on the fourth guide rail 86. The output end of the fourth driving member 83 is connected to the second pushing block 89, and the second pushing block 89 is connected to the second supporting platform 82, so that the fourth driving member 83 pushes the second supporting platform 82 to move through the second pushing block 89. Among them, the fourth driving member 83 can be a driving component such as a screw motor and a cylinder. In this embodiment, the moving direction of the second supporting platform 82 depends on the placement position of the waste liquid tank 85 and the sample receiving tray 84. If the two are placed left and right, the second supporting platform 82 moves horizontally left and right; if the two are placed front and back, the second supporting platform 82 moves horizontally front and back.

[0100] Optionally, the second horizontal driving mechanism 80 further includes a fourth sensor 87 and a fourth sensor sheet 88. The fourth sensor 87 is disposed on the supporting bottom plate 81, and the fourth sensor sheet 88 is disposed on the second supporting platform 82 and is disposed opposite to the fourth sensor 87, thereby realizing the sensing of the position of the second supporting platform 82, preventing the second supporting platform 82 from excessively moving, and facilitating the control of the second supporting platform 82 to return to the initial position (such as the fourth driving member 83 returning to zero) or move to a certain characteristic position (such as the position where the sample bottle 200 on the sample receiving tray 84 corresponds to the extraction column 100 or the position where the waste liquid tank 85 is located directly below the extraction column 100).

[0101] In some optional embodiments, such as Figure 2 As shown, the solid phase extraction device also includes a flow control valve 105 and a switch valve 102. Among them, one end of the flow control valve 105 is connected to the gas source, the other end of the flow control valve 105 is connected to the switch valve 102, and the other end of the switch valve 102 is connected to the adapter component 21, so that the gas flowing out of the switch valve 102 flows to the adapter component 21. The flow control valve 105 is used to adjust the size of the air flow flowing to the adapter component 21, and the switch valve 102 is used to control the on-off of the gas path flowing to the adapter component 21. Among them, the switch valve 102 can be a pneumatic valve, an electric valve, a hydraulic valve, etc., which is not limited in this embodiment.

[0102] Optionally, the switch valve 102 is a two-position three-way solenoid valve, and the two-position three-way solenoid valve includes a first interface, a second interface and a third interface. Among them, the first interface is connected to the flow control valve 105, the second interface is connected to the adapter assembly 21, and the third interface is left empty, and the third interface is used to discharge the gas in the extraction column 100 during the process of the seal 22 being pressed into the extraction column 100. Specifically, during the process of the seal 22 being pressed into the extraction column 100, the second interface is connected to the third interface, and the first interface is not connected to the second interface, so that the gas in the extraction column 100 is discharged through the third interface, so as to ensure that the extraction work will not start when the air pressure is not turned on, and to avoid the situation where the extraction starts before the sample bottle 200 that receives the liquid is put in place. During the formal pressurized extraction process, the first interface is connected to the second interface, and the second interface is not connected to the third interface, so as to ensure the smooth pressurization in the extraction column 100.

[0103] In some optional embodiments, such as Figure 2 As shown, the solid phase extraction device also includes a support frame 9 and an electric control component 10 disposed on the support frame 9. The electric control component 10 includes a controller 101. The controller 101 controls and is connected to the switch valve 102, the flow control valve 105, the first horizontal drive mechanism 3, the first vertical drive mechanism 4, the second vertical drive mechanism 7 and the second horizontal drive mechanism 80, and is used to control the operation of the switch valve 102, the flow control valve 105, the first horizontal drive mechanism 3, the first vertical drive mechanism 4, the second vertical drive mechanism 7 and the second horizontal drive mechanism 80 to achieve automatic extraction of the fixed extraction device. In this embodiment, the first horizontal drive mechanism 3 is disposed on the support frame 9, and the second vertical drive mechanism 7 is disposed on the support frame 9 or the support bottom plate 81.

[0104] For further information, please see Figure 2 The solid phase extraction device further includes an electrical backplane 103 and a communication adapter board 104. The electrical backplane 103, the flow control valve 105, and the switch valve 102 are respectively mounted on the support frame 9, the communication adapter board 104 and the controller 101 are respectively mounted on the electrical backplane 103, and the controller 101 can be a control panel.

[0105] The solid phase extraction device provided in this embodiment adopts positive pressure technology, combined with the sealing skirt 223 of the sealing member 22, the sealing skirt 223 and the inner wall of the extraction column 100 form an extrusion seal, and the gas source inputs a certain pressure of gas into the extraction column 100 through the first gas path, the second gas path, the confluence cavity 211 and the gas channel 221, so as to generate positive pressure in the extraction column 100. Under the action of the positive pressure, the solution to be extracted passes through the packing in the extraction column 100, and flows out from the bottom of the extraction column 100 after extraction, completing the column extraction of the extract. It can be seen that the solid phase extraction device provided in this embodiment can realize a fully automated high-throughput test of solid phase extraction and improve the efficiency of solid phase extraction.

[0106] Embodiment 2

[0107] This embodiment provides a solid phase extraction system, including a transport device and a solid phase extraction device as in the first embodiment.

[0108] Among them, the handling device is used to load and unload the positive pressure mechanism 2 from the solid phase extraction device, and / or, to take and place the extraction column 100 from the solid phase extraction device, and / or, to take and place the sample bottle 200 from the solid phase extraction device, so as to realize the automation of the installation of the positive pressure mechanism 2, the automation of taking and placing the extraction column 100 and the sample bottle 200, reduce the labor intensity, and have high efficiency and reliability.

[0109] Optionally, the handling device may be a robotic arm with grippers (such as a four-axis robotic arm, a six-axis robotic arm, etc.), a mobile robot, or an XYZ three-axis mobile mechanism, etc., which is not limited in this embodiment.

[0110] Optionally, the solid phase extraction system may further include a liquid adding device, which is used to inject the solution to be extracted into the extraction column 100 of the solid phase extraction device. The specific structure and working principle of the liquid adding device can be referred to the prior art, and this embodiment does not limit this.

[0111] Embodiment 3

[0112] This embodiment provides a control method for a solid phase extraction device, which is used to control the solid phase extraction device in the first embodiment.

[0113] like Fig.16 As shown, the control method of the solid phase extraction device includes the following steps:

[0114] S1, supporting a plurality of extraction columns 100 containing solutions to be extracted on an extraction column supporting mechanism 1;

[0115] In step S1, multiple extraction columns 100 may be placed one by one on the extraction column support mechanism 1 manually or by a transport device, so as to be supported by the extraction column support mechanism 1. Alternatively, the extraction column tray 12 may be transported to the first support platform 11 manually or by a transport device.

[0116] S2, placing a plurality of sample bottles 200 on the liquid receiving mechanism 8, and arranging the sample bottles 200 and the extraction columns 100 in a one-to-one correspondence;

[0117] In step S2, multiple sample bottles 200 can be placed on the liquid receiving mechanism 8 one by one manually or by a transport device, or a sample receiving tray 84 carrying multiple sample bottles 200 can be placed on the second supporting platform 82 manually or by a transport device. Afterwards, the sample bottles 200 are controlled to correspond to the extraction columns 100 one by one, so that the sample bottles 200 are located directly below the corresponding extraction columns 100.

[0118] It should be noted that the execution order of step S1 and step S2 can be swapped, such as executing step S2 first and then executing step S1, which is not limited in this embodiment.

[0119] S3, controlling the first vertical driving mechanism 4 to drive the positive pressure mechanism 2 to move in the vertical direction, so that the sealing member 22 is pressed into the corresponding extraction column 100;

[0120] After the seal 22 moves to the top of the corresponding extraction column 100 , the first vertical drive mechanism 4 is controlled to start, so that the first vertical drive mechanism 4 can push the seal 22 to move closer to the extraction column 100 until the sealing skirt 223 of the seal 22 is squeezed and fits with the inner wall of the extraction column 100 .

[0121] S4, opening the gas source, so that the gas source injects gas into the extraction column 100 through the gas passage 221 of the adapter component 21 and the sealing member 22;

[0122] After the seal 22 is pressed into the corresponding extraction column 100, the gas source is controlled to be turned on, so that the gas source inputs gas with a certain pressure into the confluence cavity 211 through the quick-change assembly 5, so that the gas in the confluence cavity 211 is injected into each extraction column 100 through the air channel 221 of each seal 22. When the pressure in the extraction column 100 reaches the preset pressure, extraction begins, so that the solution to be extracted flows out from the bottom end of the extraction column 100 after passing through the filler and is received by the sample bottle 200 or the waste liquid tank 85. After the extraction is completed, the gas source is controlled to be turned off.

[0123] S5 . After the extraction is completed, the first vertical driving mechanism 4 is controlled to drive the positive pressure mechanism 2 to move in the reverse direction so as to pull the sealing member 22 out of the extraction column 100 .

[0124] After the extraction is completed, the first driving member 40 of the first vertical driving mechanism 4 is controlled to start and drive the positive pressure mechanism 2 to rise, so as to pull the sealing member 22 out of the extraction column 100. Since the extraction column 100 is clamped by the extraction column cover plate 121 and the extraction column support plate 122, the extraction column 100 will not be carried up by the sealing member 22.

[0125] The control method of the solid phase extraction device provided in this embodiment supports the extraction column 100 through the extraction column support mechanism 1, the adapter component 21 can connect the gas source and the air channel 221 of the seal 22, multiple seals 22 correspond to multiple extraction columns 100 one by one, and each seal 22 can be pressed into and seal the corresponding extraction column 100 under the drive of the first vertical drive mechanism 4. The gas provided by the gas source flows into the extraction column 100 through the adapter component 21 and the air channel 221, so that the gas pressure in each extraction column 100 is increased, thereby realizing simultaneous and rapid extraction of multiple extraction columns 100, and the extract extracted by each extraction column 100 can be received by the corresponding sample bottle 200, which reduces the time required for extraction and improves the extraction efficiency.

[0126] This embodiment also provides a more detailed control method for a solid phase extraction device, which is described here by taking the transport device as a robotic arm, and specifically includes the following steps:

[0127] S01, the first horizontal driving mechanism 3, the first vertical driving mechanism 4, the second vertical driving mechanism 7 and the second horizontal driving mechanism 80 complete their respective initializations;

[0128] Specifically, initialization can be to return each component to its original position so as to control the moving distance of each component.

[0129] S02, the robot arm places the sample receiving tray 84 on the second supporting platform 82, and the second horizontal driving mechanism 80 drives the second supporting platform 82 to move, so that the sample receiving tray 84 moves to the bottom of the extraction column supporting mechanism 1;

[0130] S03, the robot arm places the extraction column tray 12 pre-installed with the extraction columns 100 on the first support platform 11, and the multiple sample bottles 200 and the multiple extraction columns 100 are opposite to each other in the vertical direction;

[0131] S04, the robot arm installs the positive pressure mechanism 2 equipped with the second quick-change joint 52 on the first quick-change joint 51 connected to the output end of the first vertical drive mechanism 4, and the second quick-change joint 52 is quickly connected to the first quick-change joint 51;

[0132] It should be noted that the execution order of steps S02 to S04 can be swapped, and this embodiment does not limit this.

[0133] S05, the robotic arm uses the liquid adding device to add the solutions to be extracted into the corresponding extraction columns 100 one by one;

[0134] S06, the first horizontal driving mechanism 3 is activated, and drives the positive pressure mechanism 2 to move to the top of the extraction column tray 12, and the sealing member 22 corresponds to the hole position of the extraction column 100 one by one;

[0135] S07, the first vertical drive mechanism 4 is activated to drive the positive pressure mechanism 2 to press down until the seal 22 enters the corresponding extraction column 100 and moves to the specified position. At this time, the outer lip portion of the sealing skirt 223 forms an extrusion seal with the interior of the extraction column 100;

[0136] S08, turning on the gas source, the gas source is connected to the quick-change assembly 5 through the flow control valve 105 and the switch valve 102, and the quick-change assembly 5 is connected to the extraction column 100 through the confluence cavity 211 and the air channel 221;

[0137] S09, the positive air pressure applied by the external air source squeezes the solution to be extracted in the extraction column 100, so that the solution to be extracted passes through the corresponding filler inside the extraction column 100 and flows out from the bottom;

[0138] S010, the extract flowing out of the bottom of the extraction column 100 falls into the sample bottle 200 corresponding to the sample receiving tray 84;

[0139] S011, after the extraction is completed, the sample receiving tray 84 is removed by the robot arm;

[0140] S012. During the experiment, the extract that does not need to be collected flows out from the end of the extraction column 100 and enters the waste liquid tank 85. A drainage tube is connected to the side of the waste liquid tank 85, and the drainage tube is used to guide the extract out of the device.

[0141] In this embodiment, the movement of the mechanism can be achieved by a motor or a cylinder, and the movement can be specifically detected and controlled in real time by sensors (such as the first sensor 42, the second sensor 94, the third sensor 73, and the fourth sensor 87) and corresponding sensor sheets (such as the first sensor sheet 43, the second sensor sheet 95, the third sensor sheet 74, and the fourth sensor sheet 88). The connection between the positive pressure mechanism 2 and the first vertical drive mechanism 4 can be achieved by a robotic arm, and the movement of the sample receiving tray 84 and the extraction column tray 12 can be achieved by a robotic arm, thereby realizing the automation of the extraction process, reducing manual labor intensity, and improving the efficiency of extraction.

[0142] Note that the above are only preferred embodiments of the present invention and the technical principles used. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments, and may include more other equivalent embodiments without departing from the concept of the present invention, and the scope of the present invention is determined by the scope of the appended claims.

Claims

1. A solid phase extraction device, characterized in that: include: An extraction column support mechanism (1) for supporting a plurality of extraction columns (100); A positive pressure mechanism (2) is located above the extraction column support mechanism (1), the positive pressure mechanism (2) comprises a transfer assembly (21) and a plurality of sealing members (22) connected to the transfer assembly (21), the sealing members (22) are arranged in a one-to-one correspondence with the extraction columns (100), an air passage (221) is provided through the sealing member (22) along the axial direction of the sealing member (22), and the transfer assembly (21) is used to connect the air source with the air passage (221) of the sealing member (22); a first vertical driving mechanism (4), connected to the positive pressure mechanism (2) or the extraction column supporting mechanism (1), and used for driving the positive pressure mechanism (2) or the extraction column supporting mechanism (1) to move in a vertical direction so as to press the sealing member (22) into the extraction column (100) or to pull the sealing member (22) out of the extraction column (100); The liquid receiving mechanism (8) is located below the extraction column supporting mechanism (1) and is used to carry a plurality of sample bottles (200). The sample bottles (200) are arranged in a one-to-one correspondence with the extraction columns (100). The sample bottles (200) are used to receive the extraction liquid discharged from the extraction columns (100).

2. The solid phase extraction device according to claim 1, characterized in that: The first vertical drive mechanism (4) is detachably connected to the positive pressure mechanism (2); the solid phase extraction device further comprises a quick-change assembly (5), the quick-change assembly (5) comprises a first quick-change connector (51) and a second quick-change connector (52) that are detachably connected, the first vertical drive mechanism (4) is connected to the first quick-change connector (51), and the adapter assembly (21) is connected to the second quick-change connector (52).

3. The solid phase extraction device according to claim 2, characterized in that: The first quick-change connector (51) is provided with a first air inlet and a first air outlet, a first air path is formed between the first air inlet and the first air outlet, and the second quick-change connector (52) is provided with a second air inlet and a second air outlet, a second air path is formed between the second air inlet and the second air outlet; The first air inlet is in communication with the air source, and the second air outlet is in communication with the adapter assembly (21); when the first quick-change connector (51) is connected to the second quick-change connector (52), the first air path is in communication with the second air path.

4. The solid phase extraction device according to claim 3, characterized in that: The adapter assembly (21) has a confluence cavity (211) connected to the gas source, the adapter assembly (21) comprises a confluence plate (212) and a fixing plate (213) connected to each other, the confluence plate (212) has a confluence groove on its surface facing the fixing plate (213), the fixing plate (213) covers the opening of the confluence groove and forms the confluence cavity (211) with the confluence groove, the fixing plate (213) has a plurality of mounting holes connected to the confluence cavity (211), the sealing members (22) are sealingly mounted in the mounting holes one by one, and the second quick-change connector (52) is connected to the confluence plate (212); The confluence plate (212) is provided with a vent hole, one end of the vent hole is in communication with the second air outlet of the second quick-change connector (52), and the other end of the vent hole is in communication with the confluence chamber (211).

5. The solid phase extraction device according to claim 4, characterized in that: The adapter assembly (21) further comprises a flow stabilizing plate (23) connected to the confluence plate (212); the flow stabilizing plate (23) is located in the confluence cavity (211) and divides the confluence cavity (211) into two upper and lower air cavities; the flow stabilizing plate (23) comprises a plurality of flow stabilizing holes which are arranged at intervals and are capable of connecting the two air cavities.

6. The solid phase extraction device according to claim 1, characterized in that: The first vertical driving mechanism (4) is connected to the positive pressure mechanism (2), and the solid phase extraction device further comprises a second vertical driving mechanism (7), wherein the second vertical driving mechanism (7) is connected to the extraction column supporting mechanism (1) and is used to drive the extraction column supporting mechanism (1) to move in a vertical direction.

7. The solid phase extraction device according to claim 1, characterized in that: Also includes: a first horizontal driving mechanism (3) connected to the first vertical driving mechanism (4), the first horizontal driving mechanism (3) being used to drive the first vertical driving mechanism (4) to move in a horizontal direction; and / or The second horizontal driving mechanism (80) is connected to the liquid contacting mechanism (8), and the second horizontal driving mechanism (80) is used to drive the liquid contacting mechanism (8) to move in a horizontal direction.

8. The solid phase extraction device according to claim 7, characterized in that: It also includes a waste liquid tank (85), which is connected to the second horizontal driving mechanism (80). The second horizontal driving mechanism (80) can drive the sample bottle (200) or the waste liquid tank (85) carried by the liquid receiving mechanism (8) to move to the bottom of the extraction column (100).

9. The solid phase extraction device according to any one of claims 1 to 8, characterized in that: The sealing member (22) comprises a connecting portion (222), a main body (220) and a sealing skirt (223); the connecting portion (222) is connected to the main body (220); the connecting portion (222) is used for sealingly connecting with the adapter assembly (21); the sealing skirt (223) is connected to an end of the main body (220) away from the connecting portion (222); the sealing skirt (223) is arranged around the outer periphery of the main body (220); when the first vertical driving mechanism (4) presses the sealing member (22) into the extraction column (100), the sealing skirt (223) can be in sealing contact with the inner wall of the extraction column (100).

10. The solid phase extraction device according to claim 9, characterized in that: The first end of the sealing skirt (223) is connected to the main body (220), the second end of the sealing skirt (223) extends toward the connecting portion (222), and the diameter of the sealing skirt (223) gradually increases from the first end to the second end.

11. The solid phase extraction device according to any one of claims 1 to 8, characterized in that: The extraction column support mechanism (1) comprises a first support platform (11) and an extraction column tray (12), wherein the first support platform (11) is used to support the extraction column tray (12); the extraction column tray (12) comprises an extraction column cover plate (121), an extraction column support plate (122), a support column (123) and a tray bottom plate (124), wherein the tray bottom plate (124) is connected to the extraction column support plate (122) via the support column (123), wherein the tray bottom plate (124) and the extraction column support plate (122) are provided with a plurality of first through holes for the extraction column (100) to pass through, and the extraction column cover plate (121) is provided with a plurality of second through holes for the sealing member (22) to pass through, corresponding to the first through holes; the extraction column cover plate (121) is provided on the extraction column support plate (122) to limit the movement of the extraction column (100) relative to the extraction column support plate (122) in a vertical direction; A first positioning member is provided on the first supporting platform (11), and the first positioning member is used to limit the extraction column tray (12) to the first supporting platform (11).

12. The solid phase extraction device according to any one of claims 1 to 8, characterized in that: The liquid receiving mechanism (8) comprises a second supporting platform (82) and a sample receiving tray (84), wherein the second supporting platform (82) is used to support the sample receiving tray (84), and the sample receiving tray (84) is provided with a plurality of placement holes for placing the sample bottles (200); a second positioning member is provided on the second supporting platform (82), and the second positioning member is used to limit the sample receiving tray (84) to the second supporting platform (82).

13. The solid phase extraction device according to any one of claims 1 to 8, characterized in that: It also includes a flow control valve (105) and a switch valve (102), one end of the flow control valve (105) is connected to the gas source, the other end of the flow control valve (105) is connected to the switch valve (102), the other end of the switch valve (102) is connected to the adapter component (21), the flow control valve (105) is used to adjust the size of the air flow flowing to the adapter component (21), and the switch valve (102) is used to control the on-off of the air path flowing to the adapter component (21).

14. The solid phase extraction device according to claim 13, characterized in that: The switch valve (102) is a two-position three-way solenoid valve, which includes a first interface, a second interface and a third interface. The first interface is connected to the flow control valve (105), the second interface is connected to the adapter assembly (21), and the third interface is used to discharge the gas in the extraction column (100) when the sealing member (22) is pressed into the extraction column (100).

15. A solid phase extraction system, characterized in that: It comprises a transport device and a solid phase extraction device as described in any one of claims 1 to 14, wherein the transport device is used to load and unload a positive pressure mechanism (2) from the solid phase extraction device, and / or to take and place an extraction column (100) from the solid phase extraction device, and / or to take and place a sample bottle (200) from the solid phase extraction device.

16. The solid phase extraction system according to claim 15, characterized in that: It also comprises a liquid adding device, which is used to inject the solution to be extracted into the extraction column (100) of the solid phase extraction device.

17. A method for controlling a solid phase extraction device, used for controlling the solid phase extraction device according to any one of claims 1 to 14, characterized in that: The control method comprises the following steps: Supporting a plurality of extraction columns (100) containing solutions to be extracted on an extraction column support mechanism (1); Placing a plurality of sample bottles (200) on the liquid receiving mechanism (8), and arranging the sample bottles (200) and the extraction columns (100) in a one-to-one correspondence; Controlling the first vertical driving mechanism (4) to drive the positive pressure mechanism (2) to move in the vertical direction so that the sealing member (22) is pressed into the corresponding extraction column (100); Opening the gas source so that the gas source injects gas into the extraction column (100) through the adapter component (21) and the gas passage (221) of the sealing component (22); After the extraction is completed, the first vertical driving mechanism (4) is controlled to drive the positive pressure mechanism (2) to move in the reverse direction, so as to pull the sealing member (22) out of the extraction column (100).

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