Pharmaceutical composition for treating cold symptom and preparation and application thereof

Abstract

The invention discloses a pharmaceutical composition for treating cold symptom and a preparation and application thereof, the pharmaceutical composition for treating cold symptom is composed of myricaria, emblic leafflower fruit, myrobalan, belleric terminalia fruit, Chinese angelica tail, saffron crocus, red sandalwood, caragana euonymus, sal ammoniac, gypsum rubrum, Tibetan cat milk, halite, white sandalwood, Himalaya salt and dried ginger. The pharmaceutical composition for treating the cold symptom is prepared into a preparation by adding pharmaceutically acceptable auxiliary materials. The pharmaceutical composition for treating the cold symptom and the preparation thereof can be used for preparing medicines for treating the cold symptom.

Description

Technical Field

[0001] The present invention belongs to the field of medicine, and in particular relates to a medicine composition for treating cold syndrome, and a preparation and application thereof. Background Art

[0002] According to the theory contained in the Four Medical Classics, a Tibetan medical treatise, Tibetan medicine categorizes illnesses into 404 categories, each encompassing a variety of symptoms related to the "three factors." Tibetan medicine's "three factors" illnesses can be grouped into two categories: cold and heat. "Bacon" illnesses are cold, "Tripa" illnesses are heat, and "Lung" illnesses combine both cold and heat.

[0003] In Tibetan medicine theory, "Bacon" disease is a cold disease, which is caused by the "Bacon" in normal physiological homeostasis due to the rise and fall and disorder of seasons, psychological phenomena, diet, lifestyle, etc. "Bacon" disease includes six categories: navel Bacon disease, iron scale Bacon disease, fire decline Bacon disease, throat obstruction Bacon disease, white paralysis Bacon disease, and dry consumption Bacon disease. Among them, navel Bacon disease is caused by four reasons: cold wind constitution, taking unfamiliar food, eating harmful food and immature products, which lead to the decline of stomach fire, indigestion of food, increased body fluid and mucus, and obstruction under the navel, dull pain, and a sense of accumulation, but no lumps when pressed, poor appetite, indigestion, severe pain when eating, and better when hungry; fire decline Bacon disease is caused by the strong cold wind, difficulty in digesting food, excessive consumption of cold food, or thin clothes that make the body cold, or too long time working in cold water or water, or eating in the late stage of fever. Too much cold food and medicine, or excessive bloodletting and purgation, will cause the function of eliminating gallbladder and fire and wind to decline, resulting in fire-deficiency Bacon disease, whose symptoms include difficulty in digesting food, abdominal distension and intestinal rumbling, stomach fullness, frequent belching, undigested food due to diarrhea, weakened physical strength, muscle emaciation, and finally edema or tumor formation; white bi Bacon disease is caused by the increase and stagnation of body fluid in the undigested parts, resulting in unbearable pain in the stomach and liver, tasteless food, vomiting or diarrhea, pain in the fish muscles of the limbs and eye sockets, vomiting of hot water, and finally spreading to the joints of the limbs and causing arthritis.

[0004] Modern medicine typically treats the symptoms of nasal congestion, inflammatory bowel disease, and white paralysis disease with anti-inflammatory and antibacterial methods, or even surgical removal of the affected organs. However, these treatments are incurable and prone to recurrence. Therefore, it is imperative to develop a safe and effective medication that can address both the symptoms and the root cause of cold symptoms. Summary of the Invention

[0005] In response to the shortcomings of the prior art, the present invention aims to provide a pharmaceutical composition, preparation, and use thereof for treating cold syndromes. The pharmaceutical composition and preparation thereof can warm the meridians and dredge the collaterals, harmonize the internal organs, dispel wind and cold, promote the circulation of qi and blood, activate blood circulation and remove blood stasis, reduce swelling and relieve pain, relax and strengthen the tendons, enhance skin elasticity and vitality, and nourish the entire body, thereby treating both the symptoms and the root cause of cold syndromes and restoring the body's original normal functions.

[0006] The purpose of the present invention is achieved through the following technical solutions: A pharmaceutical composition for treating cold syndrome comprises the following components by weight: 20-60 parts of water cypress branches, 10-50 parts of emblica fruits, 12-50 parts of terminalia chebula, 15-60 parts of terminalia chebula, 15-60 parts of angelica roots, 15-60 parts of saffron, 10-60 parts of red sandalwood, 10-50 parts of ghost arrow caragana, 15-60 parts of borax, 20-60 parts of calcite, 20-60 parts of Tibetan cat milk, 10-50 parts of bright salt, 10-50 parts of white sandalwood, 10-50 parts of Himalayan salt, and 30-100 parts of dried ginger.

[0007] Preferably, the pharmaceutical composition for treating cold syndrome is composed of the following components by weight: 20-50 parts of water cypress branches, 10-40 parts of emblica fruits, 12-40 parts of terminalia chebula, 15-50 parts of hairy terminalia chebula, 15-50 parts of angelica roots, 15-40 parts of saffron, 10-50 parts of red sandalwood, 10-40 parts of ghost arrow caragana, 15-50 parts of borax, 20-50 parts of cold water stone, 20-50 parts of Tibetan cat milk, 10-40 parts of bright salt, 10-40 parts of white sandalwood, 10-40 parts of Himalayan salt, and 30-80 parts of dried ginger.

[0008] More preferably, the pharmaceutical composition for treating cold syndrome is composed of the following components by weight: 20-40 parts of water cypress branches, 10-35 parts of emblica fruit, 12-30 parts of terminalia chebula, 15-35 parts of hairy terminalia chebula, 15-40 parts of angelica root, 15-30 parts of saffron, 10-40 parts of red sandalwood, 10-35 parts of ghost arrow caragana, 15-40 parts of borax, 20-40 parts of cold water stone, 20-40 parts of Tibetan cat milk, 10-35 parts of bright salt, 10-35 parts of white sandalwood, 10-35 parts of Himalayan salt, and 30-60 parts of dried ginger.

[0009] In this recipe, Terminalia chebula is the dried mature fruit of Terminalia chebula Retz. or Terminalia chebula Retz. var. tomentella Kurt., both of the Combretaceae family. It tastes bitter, sour, and astringent, and is warm in nature. It has the effects of astringing the lungs, astringing the intestines, and relieving gas.

[0010] Terminalia bellirica (Gaertn.) Roxb. is the dried mature fruit of the Combretaceae plant. It has a bitter taste and a neutral nature, and has the effects of clearing heat and detoxifying, as well as astringing and nourishing the blood.

[0011] Red sandalwood is the heartwood of the Myroxylon balsamum tree (Leguminosae). It has a slightly bitter, astringent flavor and cooling properties, acting on the stomach, liver, and large intestine meridians. It has been shown to relax, improve sleep, and invigorate the mind.

[0012] Tibetan cat milk: It is the dried heartwood of Rhamnella gilgitica Mansf. et Melch., a plant of the Rhamnaceae family. It tastes slightly bitter and is cool and dry in nature. It has the effects of dispelling rheumatism, astringing yellow water, reducing swelling and relieving pain, and cooling blood.

[0013] White sandalwood is the dried heartwood of the small, evergreen tree Santalum album L. of the Santalaceae family. It has a pungent flavor and warm properties, entering the lung, stomach, and spleen meridians. It has the effects of regulating qi, relieving chest tightness, dispelling cold, and relieving pain.

[0014] Himalayan salt: Also known as rose salt, Himalayan salt. It has a salty taste and enters the stomach, kidney, and large and small intestine meridians. It has the effects of nourishing the kidneys and promoting bowel movements, inducing vomiting and stopping diarrhea, and preventing diarrhea and constipation.

[0015] Tibetan medicine prescriptions also adhere to the principle of compatibility of monarch, minister, adjuvant, and guiding. In the pharmaceutical composition described herein, cypress branches, emblica fructus, terminalia chebula, and terminalia chebula are monarch herbs. These four monarch herbs enter the lung, spleen, liver, stomach, and large intestine meridians, acting together to dispel pathogenic cold throughout the body. Each of these herbs also has its own strengths. Cypress branches dispel wind, relieve exterior symptoms, promote rashes, relieve coughs, promote blood circulation and relieve pain, and dispel wind and dampness. emblica fructus promotes digestion and stomach function, promotes fluid production and relieves coughs, relieves sore throats, and moistens the lungs and resolves phlegm. Terminalia chebula is bitter, sour, and astringent, and warm in nature. Tibetan medical theory suggests that it harmonizes the three elements and strengthens the body. Terminalia chebula has astringent and blood-nourishing properties. The combined effects of these four monarch herbs, in addition to dispelling cold, also dispel wind and exterior symptoms, dispel wind and dredge the meridians, astringe the lungs and intestines, and nourish and activate blood circulation.

[0016] Angelica root, saffron, red sandalwood, Caragana sylvatica, and borax are collectively the auxiliary herbs. These five herbs are pungent and warm in nature. The warming properties help the main herbs dispel cold turbidity, strengthen the spleen and harmonize the middle, regulate qi, eliminate accumulation and soften hard masses, activate blood circulation and remove blood stasis, dispel wind and dredge the meridians, while also relieving exterior symptoms and dispelling cold, and harmonizing the Ying and Wei. Angelica root and saffron, when used together, can complement the main herbs in strengthening the blood-nourishing and blood-activating properties. Red sandalwood can relieve muscle soreness, calm the mind, stabilize emotions, relax the body and mind, improve sleep quality, and is effective for joint pain and headaches. Caragana sylvatica dispels wind and dampness, activates blood circulation and unblocks the meridians, and reduces swelling and relieves pain. According to Tibetan medical clinical experience, borax is used for abdominal distension and bowel sounds, stomach cold, constipation, dysentery, and edema.

[0017] Hanshui stone, Tibetan cat milk and Guangming salt are all adjuvants. These three adjuvants can not only assist the monarch and ministerial drugs in detoxification, opening the orifices and reducing swelling, but can also restrain the dry and hot nature of the monarch and ministerial drugs to a certain extent.

[0018] White sandalwood, Himalayan salt, and dried ginger are all used as guiding herbs. These three guiding herbs can guide all the herbs to the affected area, warm and dissolve cold, and promote the dissolution of cold stagnation, blood stasis, chest and abdominal pain caused by wind, cold, phlegm, and dampness. At the same time, they can better promote blood circulation and enhance the body's resistance. In particular, the minerals such as calcium and magnesium contained in Himalayan salt can relax the nerves, calm the mind, improve sleep, and help maintain electrolyte balance in the body; sodium ions can promote digestion and absorption, facilitate the transformation and utilization of nutrients, promote the body's metabolism, and thus enhance immunity; potassium has the effect of relieving muscle fatigue and can effectively relieve muscle soreness caused by strenuous exercise. 。 The three herbs can also work together to harmonize the other herbs in the prescription, curing the disease without harming the body.

[0019] The entire formula simultaneously dispels wind, cold, phlegm, and dampness, while nourishing and activating blood circulation. When blood is abundant, the meridians are strengthened, and when blood circulates, wind is eliminated. Qi and blood are simultaneously treated, and the five internal organs are harmonized. Simultaneously, the various herbs address both cold and hot effects, supporting each other to strengthen the spleen and harmonize the middle, regulate qi flow, dissipate cold and dampness, and warm and transform dampness, alleviating long-standing illnesses. Together, they warm the meridians and dredge the collaterals, harmonize the internal organs, dispel wind and cold, promote the circulation of qi and blood, activate blood circulation and remove stasis, reduce swelling and relieve pain, relax and strengthen muscles, enhance skin elasticity and vitality, and nourish the entire body. Therefore, it has excellent clinical efficacy for colds, headaches, difficulty in digestion, abdominal pain, vomiting and diarrhea, weakness, poor qi and blood circulation, blocked meridians, and muscle and joint pain and swelling caused by the invasion of wind, cold, and dampness.

[0020] The pharmaceutical composition for treating cold syndrome can be added with pharmaceutically acceptable excipients to prepare a preparation, such as an external bath preparation.

[0021] The pharmaceutical composition and preparation for treating cold syndrome have the effects of warming the meridians and unblocking the collaterals, coordinating the internal organs, dispelling wind and cold, promoting the circulation of qi and blood, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, relaxing and strengthening muscles, enhancing skin elasticity and vitality, and nourishing the whole body. When used to treat cold syndrome, it can achieve the effect of treating both the symptoms and the root cause, and restore the body's original normal functions.

[0022] Compared with the prior art, the present invention has the following beneficial effects: 1. The pharmaceutical composition and preparation for treating cold syndrome of the present invention have a good therapeutic effect on cold syndrome, especially on gynecological disease, gynecological disease and white paralysis disease.

[0023] 2. The bathing agent of the medicinal composition for treating cold syndrome of the present invention allows the patient to immerse in the medicinal water. Through the dual effects of physical and medicinal effects, namely, heat and the medicinal composition, the medicinal ingredients are effectively introduced into the body through open pores. At the same time, the evil qi in the skin, muscles, bones, and internal organs is expelled from the body through the open pores through sweat. This further promotes warming of the meridians and dredges the collaterals, activates cells, regulates endocrine function, enhances immunity, and restores the body to its original normal function, while avoiding the "toxic" side effects of oral medications. This constitutes the unique characteristics of Tibetan medicinal bathing: "integration of internal and external factors, harmonization of the five internal organs, and treatment of both the symptoms and the root cause."

[0024] 3. After bathing with the pharmaceutical composition of the present invention, patients can enhance their immunity and improve the "sub-health" state of modern people.

[0025] 4. The pharmaceutical composition of the present invention follows the theory of Tibetan medicine, focuses on the balance of the internal environment, coordinates the relationship between various elements of the body as a whole, activates the body's self-healing system by restoring the balance of the internal environment, and thus stimulates the body's self-healing ability to treat diseases and repair damaged tissues. DETAILED DESCRIPTION

[0026] The present invention will be further described below with reference to the examples, but the present invention is not limited to the examples. Example 1

[0027] A pharmaceutical composition for treating cold syndrome comprises the following components: 20 grams of water cypress branch, 10 grams of emblica fruit, 12 grams of terminalia chebula, 15 grams of terminalia chebula, 15 grams of angelica root, 15 grams of saffron, 10 grams of red sandalwood, 10 grams of ghost arrow caragana, 15 grams of borax, 20 grams of cold water stone, 20 grams of Tibetan cat milk, 10 grams of bright salt, 10 grams of white sandalwood, 10 grams of Himalayan salt, and 30 grams of dried ginger. Example 2

[0028] A pharmaceutical composition for treating cold syndrome comprises the following components: 40 grams of water cypress branches, 30 grams of emblica fruit, 30 grams of terminalia chebula, 35 grams of terminalia chebula, 40 grams of angelica root, 40 grams of saffron, 35 grams of red sandalwood, 30 grams of ghost arrow caragana, 40 grams of borax, 40 grams of cold water stone, 40 grams of Tibetan cat milk, 30 grams of Guangming salt, 30 grams of white sandalwood, 30 grams of Himalayan salt, and 60 grams of dried ginger. Example 3

[0029] A pharmaceutical composition for treating cold syndrome comprises the following components: 60 grams of water cypress branches, 50 grams of emblica fruit, 50 grams of terminalia chebula, 60 grams of terminalia chebula, 60 grams of angelica root, 60 grams of saffron, 60 grams of red sandalwood, 50 grams of ghost arrow caragana, 60 grams of borax, 60 grams of cold water stone, 60 grams of Tibetan cat milk, 50 grams of bright salt, 50 grams of white sandalwood, 50 grams of Himalayan salt, and 100 grams of dried ginger. Example 4

[0030] A pharmaceutical composition for treating cold syndrome comprises the following components: 50 grams of water cypress branches, 30 grams of emblica fruit, 12 grams of terminalia chebula, 25 grams of terminalia chebula, 50 grams of angelica root, 60 grams of saffron, 20 grams of red sandalwood, 35 grams of ghost arrow caragana, 15 grams of borax, 60 grams of cold water stone, 40 grams of Tibetan cat milk, 30 grams of Guangming salt, 10 grams of white sandalwood, 20 grams of Himalayan salt, and 100 grams of dried ginger. Example 5

[0031] A pharmaceutical composition for treating cold syndrome comprises the following components: 60 grams of water cypress branches, 35 grams of emblica fruit, 20 grams of terminalia chebula, 35 grams of terminalia chebula, 60 grams of angelica root, 15 grams of saffron, 35 grams of red sandalwood, 40 grams of ghost arrow caragana, 25 grams of borax, 20 grams of cold water stone, 50 grams of Tibetan cat milk, 35 grams of bright salt, 20 grams of white sandalwood, 30 grams of Himalayan salt, and 30 grams of dried ginger. Example 6

[0032] A pharmaceutical composition for treating cold syndrome comprises the following components: 20 grams of water cypress branches, 40 grams of emblica fruit, 30 grams of terminalia chebula, 50 grams of terminalia chebula, 15 grams of angelica root, 30 grams of saffron, 40 grams of red sandalwood, 10 grams of ghost arrow caragana, 40 grams of borax, 30 grams of cold water stone, 60 grams of Tibetan cat milk, 40 grams of Guangming salt, 30 grams of white sandalwood, 35 grams of Himalayan salt, and 45 grams of dried ginger. Example 7

[0033] A pharmaceutical composition for treating cold syndrome comprises the following components: 30 grams of water cypress branches, 50 grams of emblica fruit, 40 grams of terminalia chebula, 60 grams of terminalia chebula, 30 grams of angelica root, 40 grams of saffron, 50 grams of red sandalwood, 20 grams of ghost arrow caragana, 50 grams of borax, 40 grams of cold water stone, 20 grams of Tibetan cat milk, 50 grams of bright salt, 35 grams of white sandalwood, 40 grams of Himalayan salt, and 60 grams of dried ginger. Example 8

[0034] A pharmaceutical composition for treating cold syndrome comprises the following components: 40 grams of water cypress branches, 10 grams of emblica fruit, 50 grams of terminalia chebula, 15 grams of terminalia chebula, 40 grams of angelica root, 50 grams of saffron, 60 grams of red sandalwood, 30 grams of ghost arrow caragana, 60 grams of borax, 50 grams of cold water stone, 30 grams of Tibetan cat milk, 20 grams of Guangming salt, 40 grams of white sandalwood, 50 grams of Himalayan salt, and 80 grams of dried ginger. Example 9

[0035] A pharmaceutical composition for treating cold syndrome comprises the following components: 35 grams of water cypress branch, 20 grams of emblica fruit, 35 grams of terminalia chebula, 40 grams of terminalia chebula, 55 grams of angelica root, 15 grams of saffron, 10 grams of red sandalwood, 50 grams of ghost arrow caragana, 60 grams of borax, 45 grams of cold water stone, 30 grams of Tibetan cat milk, 10 grams of Guangming salt, 50 grams of white sandalwood, 10 grams of Himalayan salt, and 70 grams of dried ginger. Example 10

[0036] A topical bath preparation for treating cold symptoms comprises weighing the medicinal materials of any one of Examples 1-9, crushing them, and mixing them evenly. The preparations are then divided into 20-gram portions (for foot baths) or 40-gram portions (for full body baths). To use, soak one portion in cold water for 2 hours, then boil it for 1 hour. The medicinal solution is then diluted with water to the desired amount, and the water temperature maintained at 40-42°C for the bath.

[0037] Application Example 1 - Observation of the effect of the pharmaceutical composition of the present invention on dovetail dermatosis 1. Observation Object 80 patients with idiopathic encephalopathy (according to Tibetan medicine theory, colds and gastrointestinal colds fall under the category of idiopathic encephalopathy, so this application example selected patients with colds and gastrointestinal colds as observation subjects) were selected, including 28 males and 52 females, aged 5-75 years. Bathing with the pharmaceutical composition of the present invention was performed to observe its efficacy and adverse reactions.

[0038] 2. Diagnostic Criteria The following diagnostic criteria were selected with reference to the 2010 edition of "Eighty Thangkas of the Four Medical Classics and Their Interpretations" and the Four Medical Classics: 1. Cold Due to the invasion of wind and cold evil and the invasion of evil into the surface of the body, the ability of the body temperature center to regulate is affected, resulting in the body experiencing chills, fear of cold, fever, no sweating, sore limbs, nasal congestion, sneezing, coughing, headache, dry, itchy and painful throat; the tongue is pale red with white fur; the pulse is often floating and tight.

[0039] 2. Gastrointestinal cold The main cause of gastrointestinal colds comes from external stimuli and other factors, which cause gastrointestinal discomfort. It occurs more frequently when the weather changes from cold to warm. At the same time, bad living habits, poor diet, decreased immunity and other factors may also induce or aggravate the disease. The main manifestations are digestive system symptoms such as nausea, vomiting, abdominal pain, and diarrhea, and may also be accompanied by fever, headache, dizziness, general fatigue, white tongue coating, and slow pulse.

[0040] 3. Bathing method A foot bath or full body bath is performed using the topical bath preparation prepared by the preparation method described in Example 10 using the drug combination of the present invention. For a full body bath, the patient lies supine and immerses in the bath, typically three fingers above the navel. During the bath, the patient gently pushes on a limb with impaired mobility or rubs the painful area, providing an underwater massage or exercise. For a foot bath, the patient soaks their feet in a tub with the bath solution submerged to the calf. The bath is performed 1-2 times daily.

[0041] 4. Taboos for use Pregnant women, menstruating period, after drinking, epilepsy, infectious diseases, mental illness, active tuberculosis, bleeding tendency, liver and kidney dysfunction, severe heart disease or heart failure, etc.

[0042] V. Efficacy Evaluation Criteria 1. Cold (1) Cured: All symptoms disappear.

[0043] (2) Significant effect: Symptoms such as aversion to cold, fever, body aches, nasal congestion, sneezing, coughing, headache, dry and itchy throat and pain are significantly alleviated.

[0044] (3) Effective: Symptoms such as aversion to cold, fever, body aches, nasal congestion, sneezing, coughing, headache, dry and itchy throat and pain are alleviated.

[0045] (4) Ineffective: No significant changes in symptoms.

[0046] 2. Gastrointestinal cold (1) Cured: All symptoms disappear.

[0047] (2) Significant effect: Digestive system symptoms such as nausea, vomiting, abdominal pain, and diarrhea are significantly alleviated.

[0048] (3) Effective: Digestive system symptoms such as nausea, vomiting, abdominal pain, and diarrhea are alleviated.

[0049] (4) Ineffective: No significant changes in symptoms.

[0050] 6. Observation Results A total of 80 patients were observed, of whom 51 were cured, 16 showed marked effect, 9 were effective, and 4 were ineffective. Effective rate = (cured + marked effect + effective) / total number of cases (see Table 1).

[0051]

[0052] 7. Security No adverse reactions were observed in all subjects.

[0053] 8. Cases (1) Cold caused by wind and cold 1. Zhang, female, 38 years old. She reported aversion to cold, headache, and pale red tongue with a white coating and a floating pulse. She used the topical bath preparation prepared using the pharmaceutical composition described in Example 1 and the method described in Example 10 for a foot bath. After one foot bath, she felt her neck could move normally, her aversion to cold, headache, and headache symptoms disappeared, and she felt relaxed. Her condition returned to normal the next day.

[0054] 2. Zhou, female, 52 years old. She presented with fever, aches and pains in the limbs, nasal congestion, sneezing, cough, headache, dry and itchy throat, a pale red tongue with a white coating, and a weak and floating pulse. She took a full-body bath once daily using the topical bath preparation prepared using the pharmaceutical composition described in Example 4 and the method described in Example 10. The fever subsided on the same day, and the aches and pains in the limbs, nasal congestion, sneezing, and headache were alleviated. These symptoms resolved on the second to third day.

[0055] 3. Li, female, 5 years old. She developed sneezing, coughing, runny nose, and hoarseness due to a cold. Her pulse was weak, she felt generally unwell, and she had no appetite. She took a full-body bath once a day using the topical bath preparation prepared using the pharmaceutical composition described in Example 1 and the method described in Example 10. Her body temperature returned to normal after the bath on the first morning. However, it returned in the afternoon, and her sneezing, coughing, runny nose, and hoarseness symptoms improved. After the bath on the second day, her body temperature returned to normal, and the sneezing, coughing, runny nose, and hoarseness were significantly alleviated. She also had a desire to eat and drink. After the bath on the third day, all symptoms disappeared, and she felt more energetic.

[0056] (2) Gastrointestinal cold 1. Yang, female, 42 years old. She presented with a gastrointestinal cold, characterized by abdominal pain, nausea, vomiting, and diarrhea, as well as headaches, general fatigue, loss of appetite, and a white tongue coating. She bathed twice daily with the topical bath preparation prepared using the pharmaceutical composition described in Example 5 and the method described in Example 10. The abdominal pain, nausea, and vomiting were significantly alleviated, and she experienced hunger. These symptoms completely disappeared after the second bath. She returned to normal on the third day.

[0057] 2. Wei, female, 45 years old. She reported catching a cold after a meal and experiencing headaches, general fatigue, abdominal pain, diarrhea, nausea, vomiting, loss of appetite, a white tongue coating, and a weak pulse. She took a full-body bath once daily using the topical bath preparation prepared using the pharmaceutical composition described in Example 6 and the preparation method described in Example 10. After the first bath, she felt hungry, but the nausea, vomiting, headache, and abdominal pain disappeared, and the diarrhea eased. The symptoms disappeared after the second bath. On the third day, she returned to normal.

[0058] Application Example 2 - Observation of the effect of the pharmaceutical composition of the present invention on fire-fading bacon disease 1. Observation Object Patients with Huoshen Bacon disease (according to Tibetan medicine theory and combined with modern people's lifestyle, diet, and daily life issues, Huoshen Bacon disease reflects the increasing number of patients with exogenous cold and dampness, spleen and kidney yang deficiency and dampness stagnation. Therefore, this application example selects patients with exogenous cold and dampness, spleen and kidney yang deficiency and dampness stagnation as observation subjects) were selected. A total of 50 patients, including 18 males and 32 females, aged 18-75 years old, were selected. Bathing with the pharmaceutical composition of the present invention was performed to observe its effects and adverse reactions.

[0059] 2. Diagnostic Criteria The following diagnostic criteria were selected with reference to the 2010 edition of "Eighty Thangkas of the Four Medical Classics and Their Interpretations" and the Four Medical Classics: 1. Exogenous cold and dampness Overeating cold foods, wearing thin clothing that exposes the body to cold, spending extended time in cold water or working in water, exercising quickly while lying in a cool place, consuming excessive amounts of cold foods and medications in the late stages of a fever, or excessive bloodletting and purgation can lead to a decline in the functions that eliminate gallbladder and regulate fire and wind, resulting in a fire deficiency syndrome. Symptoms include difficulty digesting food, a feeling of fullness in the stomach, frequent belching, indigestion during purgation, decreased strength, muscle atrophy, or stiffness in the limbs, as well as edema or the formation of masses.

[0060] 2. Spleen and Kidney Yang Deficiency and Damp Stagnation It is caused by the loss of the body-warming function due to yang deficiency, and is manifested by fatigue in the limbs, knee pain in both lower limbs, fear of cold, abdominal distension, preference for massage, loose stools, fatigue, aversion to greasy food, and generalized edema with a thin and greasy tongue coating or a fat and pale tongue with tooth marks on the edges.

[0061] 3. Treatment Methods The external bath preparation prepared by the preparation method described in Example 10 using the drug combination of the present invention is used for foot bath or whole body bath according to actual conditions, 1-2 times a day.

[0062] 4. Taboos for use Pregnant women, menstruating period, after drinking, epilepsy, infectious diseases, mental illness, active tuberculosis, bleeding tendency, liver and kidney dysfunction, severe heart disease or heart failure, etc.

[0063] V. Efficacy Evaluation Criteria 1. Exogenous cold and dampness (1) Cured: All symptoms disappear.

[0064] (2) Significant effect: The main symptoms such as difficulty in digesting food, fullness in the stomach, frequent belching, diarrhea with indigestible food, weakened physical strength, dry muscles, or stiff limbs are significantly alleviated.

[0065] (3) Effective: The main symptoms such as difficulty in digesting food, fullness in the stomach, frequent belching, diarrhea with indigestible food, weakened physical strength, dry muscles, or stiff limbs are alleviated.

[0066] (4) Ineffective: No significant changes in symptoms.

[0067] 2. Spleen and Kidney Yang Deficiency and Damp Stagnation (1) Cured: All symptoms disappear.

[0068] (2) Significant effect: The main symptoms such as fatigue in the limbs, knee pain in both lower limbs, fear of cold, abdominal distension, preference for massage, loose stools, fatigue, aversion to greasy food, and general edema were significantly improved.

[0069] (3) Effective: Main symptoms such as fatigue in the limbs, knee pain in both lower limbs, fear of cold, abdominal distension, preference for massage, loose stools, fatigue, aversion to greasy food, and general edema were improved.

[0070] (4) Ineffective: No significant changes in symptoms.

[0071] 6. Observation Results A total of 50 patients were observed, of whom 26 were cured, 13 showed marked effect, 7 were effective, and 4 were ineffective. Effective rate = (cured + marked effect + effective) / total number of cases (see Table 2).

[0072]

[0073] 7. Security No adverse reactions were observed in all subjects.

[0074] 8. Cases (1) Exogenous cold and dampness 1. Jiang, female, 40 years old. She was emaciated and, due to frequent work in water, had difficulty digesting food, a distended stomach, belching, decreased strength, a deep pulse, and a pale tongue with tooth marks on the edges. She took a full-body bath once daily using the external bath preparation prepared by the pharmaceutical composition described in Example 2 and the preparation method described in Example 10. She experienced constipation, a distended stomach, and worsening belching on the first and second days of bathing. The symptoms subsided on the third day and disappeared on the seventh day.

[0075] 2. Mr. Li, male, 19 years old. He was lying on the grass to rest after playing basketball when his limbs suddenly became stiff. His family carried him to this hospital and he took a full-body bath once a day using the topical bath preparation prepared by the pharmaceutical composition described in Example 7 and the preparation method described in Example 10. After each bath, he felt relaxed and was able to stand up and walk on his own. The next day, his symptoms completely disappeared and he returned to normal.

[0076] (2) Spleen and Kidney Yang Deficiency and Damp Stagnation 1. Wu, female, 60 years old. Cold back pain, fatigue, weakness in the limbs, abdominal distension, loose stools, thin and greasy tongue coating, pale tongue with tooth marks on the edges. The external bath prepared by the preparation method described in Example 10 using the pharmaceutical composition described in Example 6 was used for full-body bathing, once a day. On the first day of bathing, the whole body felt relaxed. On the second day, the symptoms of cold back pain, fatigue, weakness in the limbs, and abdominal distension were significantly alleviated. On the sixth day of bathing, the symptoms of cold back pain, fatigue, weakness in the limbs, abdominal distension, and loose stools disappeared completely. The tongue coating was thin and not greasy, and the pale tongue with tooth marks on the edges was significantly improved. After that, the patient took a medicated bath in each season. The patient's immune function improved and he did not catch a cold for a year.

[0077] 2. He, female, 53 years old. She was weak and susceptible for many years. After entering menopause, her physical fitness declined sharply, her thyroid function declined, she suffered from thyroid nodules and breast nodules, difficulty falling asleep, insomnia and nightmares, and she could only fall asleep after taking zolbitan and estazolam tablets for a long time. After a viral infection, she suffered from headaches accompanied by tinnitus, twitching of the right index finger when it was cold, and a fat and pale tongue with tooth marks on the edges, and loose stools. She took a full-body bath using the external bath prepared by the preparation method described in Example 10 using the pharmaceutical composition described in Example 9. She took a bath once a day for 21 consecutive days. After a follow-up examination, the hypothyroidism was cured, the thyroid nodules and breast nodules were improved, the tinnitus disappeared, the difficulty falling asleep was also improved, and she no longer relied on taking medicine to fall asleep. The right index finger no longer twitched when it was cold, her resistance was enhanced, and she was no longer susceptible.

[0078] 3. Xie, a 40-year-old female, experienced sudden right abdominal pain of unknown etiology, accompanied by symptoms such as chills, dizziness, knee and ankle pain, loose stools, fatigue, and a swollen tongue with tooth marks on the edges. She took a full-body bath once daily using the topical bath preparation prepared using the pharmaceutical composition described in Example 8 and the method described in Example 10. After three days, she experienced significant improvement in chills, dizziness, knee and ankle pain. After 10 consecutive days of bathing, the chills, dizziness, knee and ankle pain, loose stools, and fatigue completely disappeared.

[0079] Application Example 3 - Observation of the effect of the pharmaceutical composition of the present invention on white paralysis 1. Observation Object Select the patient that meets white bile stagnation (according to Tibetan medicine theory, muscle blockage and meridian blockage belong to the category of white bile stagnation, so this application example selects muscle blockage and meridian blockage patient as observation object), a total of 40 examples, male 12 examples, female 28 examples, age 25-70 years old. Utilize the pharmaceutical composition of the present invention to carry out bathing, observe its effect and adverse reaction.

[0080] 2. Diagnostic Criteria The following diagnostic criteria were selected with reference to the 2010 edition of "Eighty Thangkas of the Four Medical Classics and Their Interpretations" and the Four Medical Classics: 1. Muscle numbness: Muscle numbness is caused by being in a cold environment for a long time without keeping warm, which allows cold air to invade the body. It may also be caused by staying up late for a long time and overwork, which leads to poor circulation of qi and blood in the body, blocked meridians, qi stagnation and blood stasis, resulting in one or more muscle pains, and then symptoms such as muscle numbness and pain.

[0081] 2. Joint numbness: manifested as joint swelling, which may be accompanied by local temperature increase and skin color change, or joint stiffness, such as muscle tension during sleep, long-term inactivity leading to joint adhesion, etc.

[0082] 3. Bathing method The external bath preparation prepared by the preparation method described in Example 10 using the drug combination of the present invention is used for foot bath or whole body bath according to actual conditions, 1-2 times a day.

[0083] 4. Taboos for use Pregnant women, menstruating period, after drinking, epilepsy, infectious diseases, mental illness, active tuberculosis, bleeding tendency, liver and kidney dysfunction, severe heart disease or heart failure, etc.

[0084] V. Efficacy Evaluation Criteria 1. Muscle paralysis: (1) Cured: All symptoms disappear.

[0085] (2) Significant effect: The main symptoms such as poor circulation of Qi and blood, blocked meridians, Qi stagnation and blood stasis, muscle pain, and muscle numbness were significantly improved.

[0086] (3) Effective: Improvement of the main symptoms such as poor circulation of Qi and blood, obstruction of meridians, Qi stagnation and blood stasis, muscle pain, and muscle numbness.

[0087] (4) Ineffective: No significant changes in symptoms.

[0088] 2. Joint numbness: (1) Cured: All symptoms disappear.

[0089] (2) Significant effect: The main symptoms such as joint swelling and joint stiffness are significantly alleviated.

[0090] (3) Effective: Main symptoms such as joint swelling and joint stiffness are alleviated.

[0091] (4) Ineffective: No significant changes in symptoms.

[0092] 6. Observation Results A total of 40 patients were observed, of whom 20 were cured, 12 showed marked effect, 6 were effective, and 2 were ineffective. Effective rate = (cured + marked effect + effective) / total number of cases (see Table 3).

[0093]

[0094] 7. Security No adverse reactions were observed in all subjects.

[0095] 8. Cases (1) Muscle paralysis 1. Yin, a 52-year-old female, suffered from chronic sleep deprivation and overwork, leading to poor blood circulation, blocked meridians, and qi stagnation and blood stasis. She had experienced recurrent shoulder and neck pain for ten years and right-sided sciatica for over twenty years. Her tongue was pale with tooth marks along the edges, and she also suffered from hypertension (taking medication for five years). She took a full-body bath twice daily for 12 consecutive days using the topical bath preparation prepared using the pharmaceutical composition described in Example 8 and the method described in Example 10. Her shoulder, neck, and sciatica pain symptoms completely disappeared. She subsequently continued taking her medicated bath twice a month, and her blood pressure has since returned to normal (after discontinuing medication).

[0096] 2. Dai, female, 58 years old. Cold air invaded the body, and overwork caused poor blood circulation in the body, resulting in multiple muscle aches and soreness in the lower limbs. She also had a weak, deep pulse and a pale tongue with a thin, greasy coating and tooth marks on the edges. She took a full-body bath twice daily for seven consecutive days using the topical bath preparation prepared using the pharmaceutical composition described in Example 9 and the method described in Example 10. After the first day, she felt a general sense of relief, and her muscle aches and soreness in the lower limbs showed significant improvement. After seven days, the muscle aches and soreness in the lower limbs completely disappeared.

[0097] (2) Joint obstruction 1. Ma, a 50-year-old female, experienced symmetrical pain and swelling in both elbows, making it impossible to bend them. She had sought medical treatment for over a decade without success, and the condition had become so severe that she could no longer care for herself. Several hospitals had diagnosed her with tennis elbow, golfer's elbow, osteoarthritis, and fat pad inflammation, but none were effective. She began bathing twice daily with a topical bath preparation prepared using the pharmaceutical composition described in Example 5 and the method described in Example 10. Her skin turned yellow and dull on the first day of the bath, and over the next seven days, it became increasingly darker, and a rash appeared on her body. These reactions were caused by the patient's long-term medication, which excreted toxins from the body. After 10 days, her facial skin returned to normal, and the rash resolved. After 20 days of bathing, the swelling in her elbows, which was felt when she bent them, significantly improved. After 49 days of bathing, the symmetrical pain and swelling in her elbows, which had become so severe that she could no longer bend them, had significantly improved. The twice-monthly Tibetan medicinal baths went from a necessity to a habit, becoming a part of her daily routine. So far, Ma lives and works like a normal person, can drive a car normally, and has become the main breadwinner of the family again.

[0098] 2. Xiao, male, 53 years old. He had low back pain and could not walk with his feet. He was diagnosed with lumbar degenerative changes, lumbar disc herniation, spondylolisthesis and lumbar spinal stenosis. He was not cured by deep autonomic nerve blockade, ozone analgesia, peripheral neuropathy, large manipulation of lumbar disc herniation under anesthesia, physical therapy and other methods. The patient also suffered from periarthritis of shoulder and bronchitis. He took a bath with the external-use bath prepared by the preparation method described in Example 10 of the pharmaceutical composition described in Example 3. The bath was conducted once a day for 10 consecutive days. He was able to exercise freely. He then adhered to the medicated bath for two seasons each month. He was able to do butterfly stroke, jogging and climbing, playing badminton, parallel bars and sit-ups and other exercises. Bronchitis and periarthritis of shoulder also improved.

[0099] The above cases demonstrate that the pharmaceutical composition of the present invention can achieve the technical effects described herein, but do not limit the present invention in any way. The above cases represent only a portion of clinical observations, and the pharmaceutical compositions used are also only a portion of the pharmaceutical compositions. In actual clinical use, the dosage of the specific drugs in the pharmaceutical composition can be adjusted accordingly within the scope of the present invention based on the different symptoms of the patient.

Claims

1. A pharmaceutical composition for treating cold syndrome, characterized in that: The invention is composed of the following components by weight: 20-60 parts of water cypress branches, 10-50 parts of emblica fruits, 12-50 parts of terminalia chebula, 15-60 parts of hairy terminalia chebula, 15-60 parts of angelica roots, 15-60 parts of saffron, 10-60 parts of red sandalwood, 10-50 parts of ghost arrow caragana, 15-60 parts of borax, 20-60 parts of cold water stone, 20-60 parts of Tibetan cat milk, 10-50 parts of bright salt, 10-50 parts of white sandalwood, 10-50 parts of Himalayan salt and 30-100 parts of dried ginger.

2. The pharmaceutical composition for treating cold according to claim 1, characterized in that: The invention is composed of the following components by weight: 20-50 parts of water cypress branches, 10-40 parts of emblica fruits, 12-40 parts of terminalia chebula, 15-50 parts of hairy terminalia chebula, 15-50 parts of angelica roots, 15-40 parts of saffron, 10-50 parts of red sandalwood, 10-40 parts of ghost arrow caragana, 15-50 parts of borax, 20-50 parts of cold water stone, 20-50 parts of Tibetan cat milk, 10-40 parts of bright salt, 10-40 parts of white sandalwood, 10-40 parts of Himalayan salt and 30-80 parts of dried ginger.

3. The pharmaceutical composition for treating cold according to claim 2, characterized in that: The invention is composed of the following components by weight: 20-40 parts of water cypress branches, 10-35 parts of emblica fruits, 12-30 parts of terminalia chebula, 15-35 parts of hairy terminalia chebula, 15-40 parts of angelica root, 15-30 parts of saffron, 10-40 parts of red sandalwood, 10-35 parts of ghost arrow caragana, 15-40 parts of borax, 20-40 parts of cold water stone, 20-40 parts of Tibetan cat milk, 10-35 parts of bright salt, 10-35 parts of white sandalwood, 10-35 parts of Himalayan salt and 30-60 parts of dried ginger.

4. The preparation of the pharmaceutical composition for treating cold symptoms according to any one of claims 1 to 3, characterized in that: The preparation is prepared by adding pharmaceutically acceptable excipients to the medicinal composition for treating cold.

5. The preparation of the pharmaceutical composition for treating cold according to claim 4, characterized in that: The preparation is an external bath preparation.

6. Use of the pharmaceutical composition for treating cold symptoms according to any one of claims 1 to 3, characterized in that: The medicinal composition for treating cold syndrome is used in preparing medicine for treating cold syndrome.

7. The use of the preparation of the pharmaceutical composition for treating cold syndrome according to claim 4, characterized in that: The invention relates to an application of the preparation of the pharmaceutical composition for treating cold syndrome in preparing medicine for treating cold syndrome.

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