Magnetic resonance spectrum all-in-one machine and magnetic resonance signal acquisition method

Abstract

The invention discloses a magnetic resonance spectrum all-in-one machine and a magnetic resonance signal acquisition method, and belongs to the field of electromagnetism. The magnetic resonance spectrum all-in-one machine is used for detecting paramagnetic resonance signals and nuclear magnetic resonance signals. The magnetic resonance spectrum all-in-one machine comprises a magnet, a probe, a microwave source, a radio frequency source, a paramagnetic resonance signal receiving and processing system, a nuclear magnetic resonance signal receiving and processing system and a control unit, the magnet comprises a first magnetic pole and a second magnetic pole which are oppositely arranged; the probe is arranged between the first magnetic pole and the second magnetic pole; the microwave source and the radio frequency source are respectively connected with the probe, the probe is provided with an accommodating cavity, an electron-nuclear double-resonance coil is arranged in the accommodating cavity, and the radio frequency source is connected with the electron-nuclear double-resonance coil; the probe is respectively connected with the paramagnetic resonance signal receiving and processing system and the nuclear magnetic resonance signal receiving and processing system; the microwave source and the radio frequency source are connected with the control unit. According to the embodiment of the invention, independent detection and simultaneous detection of the paramagnetic resonance signal and the nuclear magnetic resonance signal are realized.

Description

Technical Field

[0001] The present application relates to the field of electromagnetics, and in particular to an all-in-one magnetic resonance spectroscopy machine and a magnetic resonance signal acquisition method. Background Art

[0002] The electron paramagnetic resonance spectrometer is an instrument used to detect and analyze substances containing unpaired electrons. It uses the absorption of microwave energy by electrons with magnetic moments in an external magnetic field to produce transitions in the electron spin energy level, thereby realizing relevant information such as the coordination structure and defect structure related to the unpaired electron spins in the sample. The nuclear magnetic imaging spectrometer is an instrument used to measure and analyze the spin state and distribution of atomic nuclei in a sample. It uses the absorption of radio frequency energy by atomic nuclei with nuclear magnetic moments in an external magnetic field to produce transitions in the nuclear spin energy level, thereby realizing detailed analysis of the elemental composition and molecular structure related to the atomic nuclei in the sample.

[0003] Since the frequency of microwave electromagnetic waves used in electron paramagnetic resonance spectrometers is generally at the GHz level, and the frequency of radio frequency electromagnetic waves used in nuclear magnetic imaging spectrometers is generally at the MHz level, the two differ by three orders of magnitude. In addition, the designs of spectrometer components related to electromagnetic waves and sample cavities in electron paramagnetic resonance spectrometers and nuclear magnetic imaging spectrometers are also quite different. Therefore, although the research objects of both are spin systems, when analyzing the properties of the research objects, it can only be achieved by applying a frequency source separately and collecting the paramagnetic resonance signals and nuclear magnetic resonance signals of the research objects separately, which brings great inconvenience to scientific research. Summary of the invention

[0004] The embodiments of the present application provide an integrated magnetic resonance spectrometer and a magnetic resonance signal acquisition method, which solve the problems in the prior art that a microwave source and a radio frequency source cannot be applied to a test sample at the same time, and that the paramagnetic resonance signal and the nuclear magnetic resonance signal fed back by the test sample cannot be acquired simultaneously.

[0005] On the one hand, an embodiment of the present application provides an integrated magnetic resonance spectroscopy machine, the integrated magnetic resonance spectroscopy machine comprising:

[0006] A magnet, a probe, a microwave source, a radio frequency source, a paramagnetic resonance signal receiving and processing system, a nuclear magnetic resonance signal receiving and processing system, and a control unit; the magnet comprises a first magnetic pole and a second magnetic pole arranged opposite to each other, and the probe is arranged between the first magnetic pole and the second magnetic pole; the microwave source and the radio frequency source are respectively connected to the probe, and the probe has a receiving cavity, and the receiving cavity is provided with an electron-nuclear double resonance coil for placing a test sample, and the radio frequency source is connected to the electron-nuclear double resonance coil; the probe is respectively connected to the paramagnetic resonance signal receiving and processing system and the nuclear magnetic resonance signal receiving and processing system; the microwave source and the radio frequency source are respectively connected to the control unit;

[0007] The control unit is used to control the microwave source to output a microwave signal and / or the radio frequency source to output a radio frequency signal;

[0008] In the case where the microwave source outputs a microwave signal, the microwave signal output by the microwave source acts on the test sample, and the paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample; or,

[0009] In the case where the RF source outputs a RF signal, the RF signal output by the RF source acts on the test sample, and the nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample; or,

[0010] When the microwave source outputs a microwave signal and the radio frequency source outputs a radio frequency signal, the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source act on the test sample respectively, the paramagnetic resonance signal feedback from the test sample is received and processed by the paramagnetic resonance signal receiving and processing system, and the nuclear magnetic resonance signal feedback from the test sample is received and processed by the nuclear magnetic resonance signal receiving and processing system.

[0011] In some embodiments, the control unit includes a second switch and a third switch, the second switch is connected to the microwave source, and the third switch is connected to the radio frequency source;

[0012] When the second switch is turned on, the microwave signal output by the microwave source acts on the test sample; or

[0013] When the third switch is turned on, the radio frequency signal output by the radio frequency source acts on the test sample; or

[0014] When the second switch is turned on and the third switch is turned on, the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source act on the test sample respectively.

[0015] In some embodiments, the control unit further comprises a first switch, and the microwave source and the radio frequency source are respectively connected to the probe via the first switch;

[0016] When the second switch and the third switch are turned on and the first switch is turned on, the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source act on the test sample respectively; or,

[0017] When the second switch is turned on and the first switch is turned on, the microwave signal output by the microwave source acts on the test sample; or,

[0018] When the third switch is turned on and the first switch is turned on, the microwave signal output by the radio frequency source acts on the test sample.

[0019] In some embodiments, the integrated magnetic resonance spectroscopy device further comprises:

[0020] The temperature control unit is used to adjust the temperature of the probe.

[0021] In some embodiments, the integrated magnetic resonance spectroscopy device further comprises:

[0022] The frequency adjustment unit is connected to the radio frequency source and is used to adjust the frequency of the radio frequency signal output by the radio frequency source.

[0023] On the other hand, an embodiment of the present application provides a method for collecting magnetic resonance signals, which is applied to a magnetic resonance spectroscopy integrated device as in any one of the embodiments of the present application, and the method comprises:

[0024] The control unit controls the microwave source to output a microwave signal, and controls the radio frequency source to output a radio frequency signal;

[0025] The microwave signal output by the microwave source is transmitted to the probe and acts on the test sample, and the radio frequency signal output by the radio frequency source is transmitted to the electron-nuclear double resonance coil of the probe and acts on the test sample;

[0026] The paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample;

[0027] The nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample.

[0028] In some embodiments, the magnetic resonance signal acquisition method further comprises:

[0029] The control unit controls the microwave source to output a microwave signal;

[0030] The microwave signal output by the microwave source is transmitted to the probe and acts on the test sample;

[0031] The paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample.

[0032] In some embodiments, the magnetic resonance signal acquisition method further comprises:

[0033] The control unit controls the radio frequency source to output a radio frequency signal;

[0034] The radio frequency signal output by the radio frequency source is transmitted to the electron-nuclear double resonance coil of the probe and acts on the test sample;

[0035] The nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample.

[0036] In some embodiments, the magnetic resonance signal acquisition method further comprises:

[0037] The frequency adjustment unit is adjusted so that the RF source outputs a RF signal at a target RF frequency.

[0038] Adjust the temperature control unit to bring the temperature of the probe to the target temperature.

[0039] On the other hand, an embodiment of the present application provides a computer storage medium, which stores a computer program. When the computer program is executed by a processor, the steps of any method in the embodiment of the present application are performed.

[0040] The integrated magnetic resonance spectrometer provided in the embodiment of the present application includes: a magnet, a probe, a microwave source, a radio frequency source, a paramagnetic resonance signal receiving and processing system, a nuclear magnetic resonance signal receiving and processing system, and a control unit; the magnet includes a first magnetic pole and a second magnetic pole arranged opposite to each other, and the probe is arranged between the first magnetic pole and the second magnetic pole; the microwave source and the radio frequency source are respectively connected to the probe, the probe includes an electron-nuclear double resonance coil, and the radio frequency source is connected to the electron-nuclear double resonance coil; the probe is respectively connected to the paramagnetic resonance signal receiving and processing system and the nuclear magnetic resonance signal receiving and processing system; the microwave source and the radio frequency source are respectively connected to the control unit; a receiving cavity is provided in the probe, and the receiving cavity is used to place a test sample. In the embodiment of the present application, the control unit can control the timing of outputting the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source to the probe, thereby realizing that the microwave signal and the radio frequency signal act on the test sample placed in the probe accommodating cavity separately and simultaneously, and the paramagnetic resonance signal fed back by the test sample is received and processed by the paramagnetic resonance signal receiving and processing system, and the nuclear magnetic resonance signal fed back by the test sample is received and processed by the nuclear magnetic resonance signal receiving and processing system, thereby realizing the separate collection and processing of the paramagnetic resonance signal and the nuclear magnetic resonance signal, and the synchronous collection and processing. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] In order to more clearly illustrate the technical solution of the embodiments of the present application, the following is a brief introduction to the drawings required for use in the embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0042] Figure 1 A schematic diagram of the structure of a magnetic resonance spectroscopy integrated device provided in an embodiment of the present application;

[0043] Figure 2 A schematic diagram of the structure of a probe provided in an embodiment of the present application;

[0044] Figure 3 A schematic diagram of the structure of a control unit provided in an embodiment of the present application;

[0045] Figure 4 A schematic diagram of the structure of a control unit provided in an embodiment of the present application;

[0046] Figure 5 A flow chart of a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0047] Figure 6 The nuclear magnetic resonance signal experimental spectrum obtained by performing electron paramagnetic resonance testing and nuclear magnetic resonance testing on a test sample simultaneously using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0048] Figure 7 A magnetic resonance signal acquisition method provided in an embodiment of the present application performs electron paramagnetic resonance testing and nuclear magnetic resonance testing on a test sample at the same time, and obtains a paramagnetic resonance signal experimental spectrum;

[0049] Figure 8 A flowchart of a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0050] Fig. 9 A paramagnetic resonance signal experimental spectrum obtained by performing a continuous wave electron paramagnetic resonance test on a test sample using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0051] Fig.10 A paramagnetic resonance signal experimental spectrum obtained by performing a continuous wave electron paramagnetic resonance test on a test sample using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0052] Fig.11 An experimental spectrum of paramagnetic resonance signals obtained by performing an ultra-low temperature continuous wave electron paramagnetic resonance test on a test sample using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0053] Fig.12 A flow chart of a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0054] Fig.13a The nuclear magnetic resonance signal experimental spectrum obtained by performing a 6K ultra-low temperature nuclear magnetic resonance test on a test sample using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0055] Fig.13b A relaxation time diagram obtained by performing a 6K ultra-low temperature nuclear magnetic resonance test on a test sample using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0056] Fig.14 A nuclear magnetic resonance signal experimental spectrum obtained by performing a nuclear magnetic resonance test on a test sample using a magnetic resonance signal acquisition method provided in an embodiment of the present application;

[0057] Fig.15The present invention provides a method for collecting magnetic resonance signals provided in an embodiment of the present invention to perform nuclear magnetic resonance testing on a test sample, thereby obtaining an experimental spectrum of nuclear magnetic resonance signals. DETAILED DESCRIPTION

[0058] The features and exemplary embodiments of various aspects of the present application will be described in detail below. In order to make the purpose, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present application, rather than to limit the present application. For those skilled in the art, the present application can be implemented without the need for some of these specific details. The following description of the embodiments is only to provide a better understanding of the present application by illustrating the examples of the present application.

[0059] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the statement "include..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0060] Paramagnetic resonance signals are usually used to analyze electron-related characteristic information, such as defects, coordination environment, magnetic properties, etc.; nuclear magnetic resonance signals are usually used to analyze nucleus-related characteristic information, such as composition, structure, etc. With the in-depth study of nuclear magnetic theory and paramagnetic theory, the applicant found that for some substances that have both paramagnetic resonance signals and nuclear magnetic resonance signals, when microwave signals and radio frequency signals act on such substances at the same time, the paramagnetic resonance signals and nuclear magnetic resonance signals fed back by such substances are different from those when microwave signals and radio frequency signals act on such substances alone. For substances that have both paramagnetic resonance signals and nuclear magnetic resonance signals, it will be of great scientific research significance if the two signals can be combined to analyze the properties of the substance. However, to do so, it is necessary to act on such substances with microwave signals and radio frequency signals at the same time, and to collect the paramagnetic resonance signals and nuclear magnetic resonance signals fed back by such substances at the same time.

[0061] However, there is currently no effective means to achieve the simultaneous acquisition of the two signals. On the one hand, the frequency of the microwave electromagnetic wave used by the electron paramagnetic resonance spectrometer is generally at the GHz level, and the frequency of the radio frequency electromagnetic wave used by the nuclear magnetic imaging spectrometer is generally at the MHz level. The difference between the two is three orders of magnitude. Therefore, the electron paramagnetic resonance spectrometer and the nuclear magnetic imaging spectrometer can only act on the test sample alone. On the other hand, the electron paramagnetic resonance spectrometer uses a resonator to emit and control microwaves, while the nuclear magnetic imaging spectrometer uses a radio frequency coil to emit and control radio frequency signals. The two have different working principles. Therefore, microwave signals and radio frequency signals cannot act on the sample at the same time. On the other hand, since the line width of the paramagnetic resonance signal is relatively wide and its hyperfine coupling splitting constant is relatively large, the electron paramagnetic resonance spectrometer requires the magnetic field uniformity to be at the ppm level, while the spectrum resolution of the nuclear magnetic imaging spectrometer is at the ppb level, which is much higher than the electron paramagnetic resonance spectrometer's requirement for magnetic field uniformity. In summary, there is currently no effective means to achieve the synchronous emission of microwave signals and radio frequency signals, and the simultaneous acquisition of paramagnetic resonance signals and nuclear magnetic resonance signals.

[0062] In order to solve at least one of the prior art problems, the present application embodiment provides an integrated magnetic resonance spectroscopy machine and a method for using the same. The following first introduces the integrated magnetic resonance spectroscopy machine provided in the present application embodiment.

[0063] Figure 1 This is a schematic diagram of the structure of the magnetic resonance spectroscopy integrated device provided in an embodiment of the present application. Figure 2 A schematic diagram of the structure of a probe provided in an embodiment of the present application.

[0064] In some embodiments, Figure 1 and Figure 2 As shown, the magnetic resonance spectrometer 10 may include: a magnet 11, a probe 12, a microwave source 13, a radio frequency source 14, a paramagnetic resonance signal receiving and processing system 15, a nuclear magnetic resonance signal receiving and processing system 16, and a control unit 22; the magnet 11 includes a first magnetic pole 111 and a second magnetic pole 112 that are arranged opposite to each other, and the probe 12 is arranged between the first magnetic pole 111 and the second magnetic pole 112; the microwave source 13 and the radio frequency source 14 are respectively connected to the probe 12, and the probe 12 has a accommodating cavity 123, and the accommodating cavity 123 is provided with an electron-nuclear double resonance coil 121 for placing a test sample, and the radio frequency source 14 is connected to the electron-nuclear double resonance coil 121; the probe 12 is respectively connected to the paramagnetic resonance signal receiving and processing system 15 and the nuclear magnetic resonance signal receiving and processing system 16; the microwave source 13 and the radio frequency source 14 are connected to the control unit 22.

[0065] The magnet 11 is used to provide a magnetic field for the probe. The material of the magnet 11 can be a permanent magnet. The magnet 11 includes a first magnetic pole 111 and a second magnetic pole 112. One of the first magnetic pole 111 and the second magnetic pole 112 can be used as the N pole of the magnet 11, and the other magnetic pole can be used as the S pole of the magnet 11. Thus, a magnetic field pointing from the N pole to the S pole is formed between the first magnetic pole 111 and the second magnetic pole 112. In some embodiments, the magnetic field strength between the first magnetic pole 111 and the second magnetic pole 112 ranges from 0G to 6T, for example, 1T, 2T, 3T, 4T, 5T, etc. Since the line width of the paramagnetic resonance signal is wider than the line width of the nuclear magnetic resonance signal, the paramagnetic resonance signal has a ppm level requirement for magnetic field uniformity. When the magnetic field uniformity is at the ppm level, the spectral resolution of the paramagnetic resonance signal is better. The nuclear magnetic resonance signal has a ppb level requirement for magnetic field uniformity. When the magnetic field uniformity is at the ppb level, the spectral resolution of the nuclear magnetic resonance signal is better. In this embodiment, the microwave source and the radio frequency source share the magnet 11. In order to output the paramagnetic resonance signal spectrum and the nuclear magnetic resonance signal spectrum at the same time, the magnetic field uniformity of the example of the present application can be set to the ppm level. In some examples, in order to reduce the influence of the magnetic field uniformity on the quality of the nuclear magnetic resonance signal spectrum when the magnetic field uniformity is at the ppm level, obtain a nuclear magnetic resonance signal spectrum with better quality, and improve the resolution of the nuclear magnetic resonance signal spectrum, the magnetic field strength between the first magnetic pole 111 and the second magnetic pole 112 can be less than or equal to 1T, for example, 0.1T, 0.2T, 0.3T, 0.4T, 0.5T, 0.6T, 0.7T, 0.8T, 0.9T, etc.

[0066] The microwave source 13 is used to output microwave signals. The microwave source 13 can output microwave signals to the probe 12, and transmit the microwave signals to the test sample placed in the electron nuclear double resonance (ENDOR) coil 121 through the probe 12 accommodating cavity 123. After receiving the microwave signal, the test sample will feedback the corresponding paramagnetic resonance signal. The paramagnetic resonance signal receiving and processing system 15 is used to collect the paramagnetic resonance signal fed back by the test sample, process the paramagnetic resonance signal, and output the corresponding paramagnetic resonance signal spectrum. The frequency of the microwave signal output by the microwave source 13 can be adjusted. In some examples, the frequency range of the microwave signal output by the microwave source includes L, S, X, K, Q, and W bands, wherein the frequency range of the L band is 1 to 2 GHz, the frequency range of the S band is 2 to 4 GHz, the frequency range of the X band is 8 to 12 GHz or 7 to 11.2 GHz, the frequency range of the K band is 10.9 to 36 GHz, the frequency range of the Q band is 36 to 46 GHz, and the frequency range of the W band is 75 to 110 GHz.

[0067] The RF source 14 is used to output a RF signal. The RF signal output by the RF source 14 is sent to the electron-nuclear double resonance coil 121 of the probe 12, and acts on the test sample through the electron-nuclear double resonance coil 121. After receiving the RF signal, the test sample will feedback a corresponding nuclear magnetic resonance signal. The nuclear magnetic resonance signal receiving and processing system 16 is used to collect the nuclear magnetic resonance signal fed back by the test sample, process the nuclear magnetic resonance signal, and output a corresponding nuclear magnetic resonance signal spectrum. The frequency of the RF signal output by the RF source 14 is adjustable. In some examples, the frequency of the RF signal output by the RF source includes 1 H. 19 F. 23 Na, 27 Al and other magnetic nucleus-related frequency bands with nuclear magnetic resonance signals.

[0068] The cross-sectional shape of the accommodating cavity along its radial direction includes but is not limited to a circle, an ellipse, a quadrilateral, etc.

[0069] The control unit 22 is used to control the microwave source 13 to output a microwave signal and / or the radio frequency source 14 to output a radio frequency signal.

[0070] In some examples, the control unit 22 can control the microwave source 13 to output a microwave signal and / or the radio frequency source 14 to output a radio frequency signal respectively through a control signal. For example, the control unit 22 can output a microwave output signal to the microwave source 13, and the microwave source 13 outputs a microwave signal in response to receiving the microwave output signal. The control unit 22 can also output a radio frequency output signal to the radio frequency source 14, and the radio frequency source 14 outputs a radio frequency signal in response to receiving the radio frequency output signal. The control unit 22 can also output a microwave output signal to the microwave source 13 and output a radio frequency output signal to the radio frequency source 14, and the microwave source 13 outputs a microwave signal in response to receiving the microwave output signal, and the radio frequency source 14 outputs a radio frequency signal in response to receiving the radio frequency output signal.

[0071] Figure 3 A schematic diagram of the structure of a control unit provided in an embodiment of the present application. In some examples, such as Figure 3 As shown, the control unit 22 may include a main control unit 221 and a slave control unit 222 connected to the main control unit 221. The main control unit 221 may be connected to one of the microwave source 13 and the radio frequency source 14, and the slave control unit 222 may be connected to the other of the microwave source 13 and the radio frequency source 14. In this example, taking the main control unit 221 being connected to the microwave source 13 and the slave control unit 222 being connected to the radio frequency source 14 as an example, the process of the control unit 22 controlling the microwave source 13 to output a microwave signal and / or the radio frequency source 14 to output a radio frequency signal is described.

[0072] In a specific example, the main control unit 221 may output a microwave output signal to the microwave source 13, and the microwave source 13 outputs a microwave signal in response to receiving the microwave output signal.

[0073] In a specific example, the main control unit 221 can output a RF output signal to the slave control unit 222. The slave control unit 222 outputs a RF output signal to the RF source 14 in response to receiving the RF output signal output by the main control unit 221. The RF source 14 outputs a RF signal in response to receiving the RF output signal output by the slave control unit 222.

[0074] In a specific example, the main control unit 221 can output a microwave output signal to the microwave source 13, and output a radio frequency output signal to the slave control unit 222. The microwave source 13 outputs a microwave signal in response to receiving the microwave output signal. The slave control unit 222 outputs a radio frequency output signal to the radio frequency source 14 in response to receiving the radio frequency output signal output by the main control unit 221, and the radio frequency source 14 outputs a radio frequency signal in response to receiving the radio frequency output signal output by the slave control unit 222.

[0075] Figure 4 A schematic diagram of a control unit provided in an embodiment of the present application. In some examples, in combination with Figure 1 and Figure 4 The control unit 22 may include a second switch 223 and a third switch 224, wherein the second switch 223 is connected to the microwave source 13, and the third switch 224 is connected to the radio frequency source 14. The second switch 223 is used to control the microwave source 13 to output a microwave signal, and the third switch 224 is used to control the radio frequency source 14 to output a radio frequency signal. The second switch 223 and the third switch 224 may be electronic switches or software programs. The following describes the process of the second switch 223 controlling the microwave source 13 to output a microwave signal and the third switch 224 controlling the radio frequency source 14 to output a radio frequency signal, taking the second switch 223 and the third switch 224 as software programs as an example.

[0076] The second switch 223 and the third switch 224 can be configured by the host computer. When the second switch 223 is configured to 0, the microwave source 13 does not output microwave signals to the outside; when the second switch 223 is configured to 1, the microwave source 13 outputs microwave signals to the outside. When the third switch 224 is configured to 0, the radio frequency source 14 does not output radio frequency signals to the outside; when the third switch 224 is configured to 1, the radio frequency source 14 outputs radio frequency signals to the outside. When the second switch 223 is configured to 1 and the third switch 224 is configured to 1, the microwave source 13 outputs microwave signals to the outside, and the radio frequency source 14 outputs radio frequency signals to the outside. In this application scenario, the second switch 223 and the third switch 224 can be configured separately by the host computer to realize the separate transmission of microwave signals and radio frequency signals, but the second switch 223 and the third switch 224 cannot be configured at the same time to ensure that the clock of the microwave source 13 outputting microwave signals to the outside is consistent with the clock of the radio frequency source 14 outputting radio frequency signals to the outside, thereby realizing the synchronous transmission of microwave signals and radio frequency signals.

[0077] In some examples, in order to ensure that the microwave source 13 outputs the microwave signal and the RF source 14 outputs the RF signal at the same clock, and realize the synchronous transmission of the microwave signal and the RF signal, the microwave source 13 outputs the microwave signal and the RF signal at the same clock. Figure 1 and Figure 4 The control unit 22 may further include a first switch 225, through which the microwave source 13 and the radio frequency source 14 are respectively connected to the probe 12. The first switch 225 is used to control the transmission and interruption of signals between the microwave source 13 and the radio frequency source 14 and the probe 12. The first switch 225 may be an electronic switch or a software program.

[0078] The first switch 225 can be configured by the host computer. The following takes the first switch 225 as a software program as an example to describe the transmission process of microwave signals and radio frequency signals by controlling the states of the first switch 225, the second switch 223 and the third switch 224.

[0079] In some examples, when the first switch 225 is configured to 0, the first switch 225 is in an off state. At this time, if a signal is transmitted to the first switch 225, the transmission of the signal is interrupted here; when the first switch 225 is configured to 1, it is in an on state, and the signal transmitted to the first switch 225 continues to be transmitted backward. The host computer first configures the second switch 223 and the third switch 224 to 1, and the first switch to 0. At this time, the microwave signal transmitted by the microwave source 13 is intercepted when it is transmitted to the first switch 225, and the radio frequency signal transmitted by the radio frequency source 14 is intercepted when it is transmitted to the first switch 225. Subsequently, the host computer configures the first switch to 1. At this time, the radio frequency signal and the microwave signal intercepted by the first switch 225 are synchronously transmitted to the probe 12.

[0080] The working principle of the magnetic resonance spectroscopy integrated device in the embodiment of the present application is as follows:

[0081] When the control unit 22 controls the microwave source 13 to output a microwave signal, the microwave signal output by the microwave source 13 acts on the test sample, and the paramagnetic resonance signal receiving and processing system 15 receives and processes the paramagnetic resonance signal fed back by the test sample.

[0082] When the control unit 22 controls the RF source 14 to output a RF signal, the microwave signal output by the RF source 14 acts on the test sample, and the nuclear magnetic resonance signal receiving and processing system 16 receives and processes the nuclear magnetic resonance signal fed back by the test sample.

[0083] When the control unit 22 controls the microwave source 13 to output a microwave signal, and controls the radio frequency source 14 to output a radio frequency signal, the microwave signal output by the microwave source 13 acts on the test sample, the microwave signal output by the radio frequency source 14 acts on the test sample, the paramagnetic resonance signal receiving and processing system 15 receives and processes the paramagnetic resonance signal fed back by the test sample, and the nuclear magnetic resonance signal receiving and processing system 16 receives and processes the nuclear magnetic resonance signal fed back by the test sample.

[0084] In the embodiment of the present application, the control unit 22 can control the timing of the microwave source 13 outputting microwave signals and the radio frequency source 14 outputting radio frequency signals, thereby controlling the timing of the microwave signal and the radio frequency signal being transmitted to the probe 12, thereby realizing the timing of the paramagnetic resonance signal receiving and processing system 15 receiving and processing the paramagnetic resonance signal fed back by the test sample, and the nuclear magnetic resonance signal receiving and processing system 16 receiving and processing the nuclear magnetic resonance signal fed back by the test sample, thereby realizing the separate acquisition and processing of the paramagnetic resonance signal and the nuclear magnetic resonance signal, as well as the synchronous acquisition and processing.

[0085] In some embodiments, Figure 1As shown, the magnetic resonance spectrometer integrated machine may also include: a temperature control unit 20. The temperature control unit 20 is used to adjust the temperature of the probe. The temperature of the probe can be adjusted by the temperature control unit 20. In some examples, the temperature control unit 20 can adjust the temperature of the probe within the range of 4K to 800K. For example, the temperature of the probe can be adjusted to 5K, 6K, 7K, 100K, 273.15K, 300K, 400K, 500K, 600K and other temperatures. In some examples, the temperature control unit 20 may include a control unit, a temperature adjustment device and a temperature holding device, the control unit may send a temperature adjustment instruction to the temperature adjustment device, and the temperature adjustment device adjusts the temperature of the temperature holding device to the target temperature after receiving the temperature adjustment instruction, the temperature holding device has a housing cavity, the housing cavity is used to accommodate the probe, and the temperature holding device can transfer the temperature to the probe so that the temperature of the probe is also maintained at the target temperature. In some examples, the temperature adjustment device may be a heater or a cooler, etc. In some examples, the temperature control unit 20 may include a liquid nitrogen system, through which ultra-low temperature regulation can be achieved. For example, the temperature of the probe can be adjusted to ultra-low temperatures such as 1K, 2K, 3K, 4K, 5K, and 6K.

[0086] In some embodiments, Figure 1 As shown, the magnetic resonance spectroscopy integrated device may also include: a frequency adjustment unit 21, the frequency adjustment unit 21 is connected to the RF source 14, and the frequency adjustment unit 21 is used to adjust the frequency of the RF signal output by the RF source 14. In some examples, the frequency adjustment unit 21 may be a variable resistor, and by adjusting the resistance value of the variable resistor, the frequency of the RF signal may be adjusted, thereby expanding the frequency range of the RF signal output by the RF source. In some examples, the frequency adjustment unit 21 may be an inductor and a capacitor connected to the inductor, and by adjusting the value of the inductor and / or the capacitor, the frequency of the RF signal may be adjusted, thereby expanding the frequency range of the RF signal output by the RF source. In some examples, the frequency range of the RF signal output by the RF source is 5MHz to 30MHz, for example, 5MHz, 8MHz, 12MHz, 15MHz, 20MHz, 25MHz, etc.

[0087] Figure 5 The flowchart of a magnetic resonance signal acquisition method provided in an embodiment of the present application is applied to the above-mentioned magnetic resonance spectroscopy integrated machine. Figure 5 As shown, the magnetic resonance signal acquisition method may specifically include the following steps:

[0088] S31. The control unit controls the microwave source to output a microwave signal, and controls the radio frequency source to output a radio frequency signal.

[0089] S32. The microwave signal output by the microwave source is transmitted to the probe and acts on the test sample, and the radio frequency signal output by the radio frequency source is transmitted to the electron-nuclear double resonance coil of the probe and acts on the test sample.

[0090] S33. The paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample.

[0091] S34. The nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample.

[0092] In the embodiment of the present application, the microwave source 13 is controlled to output a microwave signal by the control unit 22, and the radio frequency source 14 is controlled to output a radio frequency signal, thereby realizing synchronous transmission of the microwave signal output by the microwave source 13 and the radio frequency signal output by the radio frequency source 14. The microwave signal is transmitted to the probe 12, and then transmitted to the test sample placed in the accommodating cavity 123 via the probe 12. The radio frequency signal is transmitted to the electron-nuclear double resonance coil 121, and then transmitted to the test sample placed in the accommodating cavity 123 via the electron-nuclear double resonance coil 121. The paramagnetic resonance signal feedback from the test sample is received and processed by the paramagnetic resonance signal receiving and processing system 15, and the nuclear magnetic resonance signal feedback from the test sample is received and processed by the nuclear magnetic resonance signal receiving and processing system 16, thereby realizing synchronous acquisition and processing of the paramagnetic resonance signal and the nuclear magnetic resonance signal, and providing convenient conditions for conducting more in-depth research on the test sample.

[0093] In some examples, the test sample can be a TEMPOL (a stable, cell-permeable nitrosamine oxide, CAS No. 2226-96-2) aqueous solution having both nuclear magnetic resonance and paramagnetic resonance signals. TEMPOL free radical is a common stable free radical, and the line width and intensity of the paramagnetic resonance signal are affected by the concentration of TEMPOL; the protons contained in the water molecules in its aqueous solution ( 1 H) is the object of nuclear magnetic research. Figure 5 The method shown in the figure was used to perform nuclear magnetic resonance and electron paramagnetic resonance tests on the test sample at the same time, and the results were as follows: Figure 6 The experimental spectrum of the nuclear magnetic resonance signal shown in Figure 7 Experimental spectrum of paramagnetic resonance signal shown.

[0094] The paramagnetic test conditions are: room temperature, frequency 9.67 GHz, microwave power 0.2 mW, central magnetic field 3450 G, scanning range 3350-3550 G, modulation amplitude 0.1 G, modulation frequency 100 kHz, time constant 0.1 s, scanning number 1. Under these test conditions, by implementing the present application, for example Figure 5 The method shown in Figure 7 The paramagnetic experimental spectrum shown. Figure 7It can be seen that the paramagnetic resonance signal appears in the range of 3420G to 3470G. Within this range, the maximum value of the paramagnetic resonance signal is about 23 and the minimum value is about -23.

[0095] The nuclear magnetic test conditions are: room temperature, main frequency 21.9MHz, test magnetic core is 1H, pulse sequence type CPMG, sampling frequency 250kHz, 90 degree pulse width 2.8μs, waiting time 15s, accumulation times 4 times, echo time 2ms, echo number 8000. Under these test conditions, by implementing this application, for example Figure 5 The method shown in Figure 6 The NMR experimental spectrum shown. Figure 6 It can be seen that in the range of about 0 to 1 ms, the amplitude of the NMR signal of the test sample decays exponentially.

[0096] It can be seen from the examples disclosed in the present invention that, for test samples having both nuclear magnetic resonance and paramagnetic resonance signals, the integrated magnetic resonance spectrometer of the embodiment of the present application has the ability to synchronously test the nuclear magnetic resonance signal and the paramagnetic resonance signal.

[0097] In some examples, such as Figure 5 As shown, the magnetic resonance signal acquisition method includes steps S31, S32, S33, and S34, and the method may further include S29 and S30.

[0098] S29. Adjust the frequency adjustment unit so that the RF source outputs a RF signal at a target RF frequency.

[0099] S30, adjusting the temperature control unit to make the temperature of the probe reach the target temperature.

[0100] The target radio frequency may be a radio frequency set manually, and the target temperature may be a temperature set manually.

[0101] Figure 8 The flowchart of a magnetic resonance signal acquisition method provided in an embodiment of the present application is applied to the above-mentioned magnetic resonance spectroscopy integrated machine. Figure 8 As shown, the magnetic resonance signal acquisition method may specifically include the following steps:

[0102] S41. The control unit controls the microwave source to output a microwave signal.

[0103] S42. The microwave signal output by the microwave source is transmitted to the probe and acts on the test sample.

[0104] S43. The paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample.

[0105] In the embodiment of the present application, the control unit 22 controls the microwave source 13 to output a microwave signal. The microwave signal output by the microwave source 13 is transmitted to the probe 12, and then transmitted to the test sample placed in the accommodating cavity 123 via the probe 12. The paramagnetic resonance signal receiving and processing system 15 receives and processes the paramagnetic resonance signal fed back by the test sample. Thus, the collection and processing of the paramagnetic resonance signal fed back by the test sample is realized.

[0106] In some examples, the test sample can be a paramagnetic sample DPPH (1,1-diphenyl-2-trinitrophenylhydrazine, CAS No. 1898-66-4). Figure 8 The method shown in the figure was used to perform continuous wave electron paramagnetic resonance test on the test sample, and the results were as follows: Fig. 9 The paramagnetic resonance signal experimental spectrum shown. In the example disclosed in this disclosure, the paramagnetic test conditions are: 6K ultra-low temperature, frequency 9.75GHz, microwave power 0.2mW, central magnetic field 3470G, scanning range 3420-3520G, modulation amplitude 1G, modulation frequency 100kHz, time constant 0.1s, scanning number 1 time. Fig. 9 It can be seen that the maximum value of the paramagnetic resonance signal appears near the central magnetic field of 3470G, which is about 14000.

[0107] It can be seen from the examples disclosed in the present invention that, for a test sample having a paramagnetic resonance signal, the integrated magnetic resonance spectrometer of the embodiment of the present application can realize the ability to perform electron paramagnetic resonance testing under ultra-low temperature experimental conditions.

[0108] In some examples, the test sample can be a TEMPOL free radical aqueous solution with a concentration in the range of 0-100 mM. The TEMPOL free radical aqueous solutions with concentrations of 0 mM, 0.1 mM, 0.2 mM, 1 mM, 2 mM, 4 mM, 10 mM, 20 mM, 30 mM, and 100 mM are selected, and the test sample can be a TEMPOL free radical aqueous solution with a concentration in the range of 0-100 mM. Figure 8 The method shown in the figure was used to perform continuous wave electron paramagnetic resonance test on the test sample, and the results were as follows: Fig.10 The paramagnetic resonance signal experimental spectrum shown. The paramagnetic test conditions are: 6K ultra-low temperature, frequency 9.67GHz, microwave power 0.2mW, central magnetic field 3450G, scanning range 3350-3550G, modulation amplitude 0.1G, modulation frequency 100kHz, time constant 0.1s, scanning number 1 time. Fig.10 It can be seen that the paramagnetic resonance signal peak values ​​of the test samples are different when the concentrations are different, and the greater the concentration, the greater the paramagnetic resonance signal peak value.

[0109] It can be seen from the examples disclosed in the present invention that, for test samples having both nuclear magnetic resonance signals and paramagnetic resonance signals, the integrated magnetic resonance spectrometer of the embodiment of the present application has the ability to perform electron paramagnetic resonance testing under ultra-low temperature experimental conditions.

[0110] In some examples, the test sample can be a 1 mM TEMPOL (CAS No. 2226-96-2) free radical aqueous solution. Figure 8 The method shown in the figure was used to perform 6K ultra-low temperature continuous wave electron paramagnetic resonance test on the test sample, and the following results were obtained: Fig.11 The paramagnetic resonance signal experimental spectrum shown. In the disclosed example, the paramagnetic test conditions are: 6K ultra-low temperature, frequency 9.75GHz, microwave power 0.2mW, central magnetic field 3480G, scanning range 3330-3630G, modulation amplitude 1G, modulation frequency 100kHz, time constant 0.1s, scanning number 1. Compared with the previous example, the microwave signal frequency and central magnetic field strength of this example have changed. From Fig.11 It can be seen that the paramagnetic resonance signal appears in the range of 3430G to 3540G. Within this range, the maximum value of the paramagnetic resonance signal is about 120 and the minimum value is about -180.

[0111] It can be seen from the examples disclosed in the present invention that, for a test sample having both a nuclear magnetic resonance signal and a paramagnetic resonance signal, the integrated magnetic resonance spectrometer of the embodiment of the present application can perform paramagnetic resonance testing at different microwave signal frequencies.

[0112] Fig.12 The flowchart of a magnetic resonance signal acquisition method provided in an embodiment of the present application is applied to the above-mentioned magnetic resonance spectroscopy integrated machine. Fig.12 As shown, the magnetic resonance signal acquisition method may specifically include the following steps:

[0113] S51. The control unit controls the radio frequency source to output a radio frequency signal.

[0114] S52. The radio frequency signal output by the radio frequency source is transmitted to the electron-nuclear double resonance coil of the probe and acts on the test sample.

[0115] S53. The nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample.

[0116] In the embodiment of the present application, the control unit 22 outputs a radio frequency signal from the radio frequency source 14. The radio frequency signal output by the radio frequency source 14 is transmitted to the electron-nuclear double resonance coil 121, and then transmitted to the test sample placed in the accommodating cavity 123 via the electron-nuclear double resonance coil 121. The nuclear magnetic resonance signal receiving and processing system 16 receives and processes the nuclear magnetic resonance signal fed back by the test sample. This realizes the collection and processing of the nuclear magnetic resonance signal fed back by the test sample.

[0117] In some examples, the test sample is a latex tube. Latex tube is a common consumable material. 1 H), the relaxation time T2 is moderate. Fig.12 The test sample was subjected to 6K ultra-low temperature low field nuclear magnetic resonance testing using the method shown in FIG. Fig.13a The experimental spectrum of the NMR signal shown and Fig.13b In the example disclosed in this disclosure, the nuclear magnetic test conditions are: 6K ultra-low temperature, main frequency 22MHz, and the test magnetic core is 1 H, pulse sequence type MultSolidEcho, sampling frequency 5000kHz, 90 degree pulse width 3μs, waiting time 10s, accumulation times 8 times, echo number 24 (minimum echo time 0.05ms, maximum echo time 0.3ms). Fig.13a It can be seen that the NMR signal intensity decays exponentially in the range of 0 to 0.11 s. Fig.13b It can be seen that the relaxation time of the test sample is about 0.049s.

[0118] It can be seen from the examples disclosed in the present invention that, for test samples having nuclear magnetic resonance signals, the integrated magnetic resonance spectrometer of the embodiment of the present application has the ability to perform nuclear magnetic resonance testing under ultra-low temperature experimental conditions.

[0119] In some examples, the test sample can be a TEMPOL free radical aqueous solution with a concentration in the range of 0-100 mM, and the magnetic core of the TEMPOL free radical aqueous solution is 1 H. TEMPOL free radical aqueous solutions with concentrations of 0mM, 0.1mM, 0.2mM, 1mM, 2mM, 4mM, 10mM, 20mM, 30mM, and 100mM were selected, and the test samples were subjected to nuclear magnetic resonance tests with the above method, and the following results were obtained: Fig.14 The nuclear magnetic resonance signal experimental spectrum shown in FIG. In the example disclosed in this disclosure, the nuclear magnetic resonance test conditions are: room temperature, main frequency 21.9 MHz, and the test magnetic core is 1H, pulse sequence type CPMG, sampling frequency 250kHz, 90 degree pulse width 2.8μs, waiting time 1s, accumulation times 8 times, shortest echo time 0.1ms, maximum echo time 2ms, the number of echoes is 1000-8000 according to the signal attenuation law. Fig.14 It can be seen that the NMR signal decay time of the test samples is different for different concentrations, and the higher the concentration, the shorter the NMR signal decay time.

[0120] It can be seen from the examples disclosed in the present invention that, for test samples having both nuclear magnetic resonance signals and paramagnetic resonance signals, the integrated magnetic resonance spectrometer of the embodiment of the present application has the ability to perform nuclear magnetic resonance testing under ultra-low temperature experimental conditions.

[0121] In some examples, the test sample may be a fluororubber having a magnetic core of 19 F. Through this embodiment Fig.12 The method shown in the figure is used to test the test sample by performing a nuclear magnetic resonance signal test, and the following is obtained: Fig.15 The nuclear magnetic resonance signal experimental spectrum shown in FIG. In the example disclosed in this disclosure, the nuclear magnetic resonance test conditions are: room temperature, main frequency 19MHz, and the test magnetic core is 19 F, pulse sequence type CPMG-VD1, sampling frequency 200kHz, 90 degree pulse width 2.4μs, waiting time 2000ms, accumulation times 128 times, echo number 46. Fig.15 It can be seen that in the range of 0 to 25 ms, the NMR signal of the test sample decays exponentially.

[0122] It can be seen from the examples disclosed in the present invention that, for test samples having nuclear magnetic resonance signals, the integrated magnetic resonance spectrometer of the embodiments of the present application has nuclear magnetic resonance testing capabilities.

[0123] It can be seen from the above examples that for test samples with different magnetic nuclei, the integrated magnetic resonance spectrometer of the embodiment of the present application has the ability to perform nuclear magnetic resonance testing.

[0124] An embodiment of the present application further provides a computer storage medium, which stores a computer program. When the computer program is executed by a processor, the steps of any method in the embodiment of the present application are performed.

[0125] It should also be noted that the exemplary embodiments mentioned in this application describe some methods or systems based on a series of steps or devices. However, this application is not limited to the order of the above steps, that is, the steps can be performed in the order mentioned in the embodiment, or in a different order from the embodiment, or several steps can be performed simultaneously.

[0126] The above is only a specific implementation of the present application. Those skilled in the art can clearly understand that for the convenience and simplicity of description, the specific working processes of the systems, modules and units described above can refer to the corresponding processes in the aforementioned method embodiments, and will not be repeated here. It should be understood that the protection scope of the present application is not limited to this. Any technician familiar with the technical field can easily think of various equivalent modifications or replacements within the technical scope disclosed in this application, and these modifications or replacements should be included in the protection scope of this application.

Claims

1. A magnetic resonance spectroscopy integrated machine, characterized in that: include: A magnet, a probe, a microwave source, a radio frequency source, a paramagnetic resonance signal receiving and processing system, a nuclear magnetic resonance signal receiving and processing system, and a control unit; the magnet comprises a first magnetic pole and a second magnetic pole arranged opposite to each other, and the probe is arranged between the first magnetic pole and the second magnetic pole; the microwave source and the radio frequency source are respectively connected to the probe, the probe has a receiving cavity, an electron-nuclear double resonance coil for placing a test sample is arranged in the receiving cavity, and the radio frequency source is connected to the electron-nuclear double resonance coil; the probe is respectively connected to the paramagnetic resonance signal receiving and processing system and the nuclear magnetic resonance signal receiving and processing system; the microwave source and the radio frequency source are respectively connected to the control unit; The control unit is used to control the microwave source to output a microwave signal and / or the radio frequency source to output a radio frequency signal; In the case where the microwave source outputs a microwave signal, the microwave signal output by the microwave source acts on the test sample, and the paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample; or In the case where the RF source outputs a RF signal, the RF signal output by the RF source acts on the test sample, and the nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample; or, In the case where the microwave source outputs a microwave signal and the radio frequency source outputs a radio frequency signal, the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source act on the test sample respectively, the paramagnetic resonance signal fed back by the test sample is received and processed by the paramagnetic resonance signal receiving and processing system, and the nuclear magnetic resonance signal fed back by the test sample is received and processed by the nuclear magnetic resonance signal receiving and processing system.

2. The magnetic resonance spectroscopy integrated device according to claim 1, characterized in that: The control unit comprises a second switch and a third switch, the second switch is connected to the microwave source, and the third switch is connected to the radio frequency source; When the second switch is turned on, the microwave signal output by the microwave source acts on the test sample; or When the third switch is turned on, the radio frequency signal output by the radio frequency source acts on the test sample; or When the second switch is turned on and the third switch is turned on, the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source act on the test sample respectively.

3. The integrated magnetic resonance spectrometer according to claim 2, characterized in that: The control unit further comprises a first switch, and the microwave source and the radio frequency source are respectively connected to the probe via the first switch; When the second switch and the third switch are turned on, and the first switch is turned on, the microwave signal output by the microwave source and the radio frequency signal output by the radio frequency source act on the test sample respectively; or, When the second switch is turned on and the first switch is turned on, the microwave signal output by the microwave source acts on the test sample; or, When the third switch is turned on and the first switch is turned on, the microwave signal output by the radio frequency source acts on the test sample.

4. The integrated magnetic resonance spectrometer according to any one of claims 1 to 3, characterized in that: Also includes: The temperature control unit is used to adjust the temperature of the probe.

5. The integrated magnetic resonance spectrometer according to any one of claims 1 to 3, characterized in that: Also includes: A frequency adjustment unit, wherein the frequency adjustment unit is connected to the radio frequency source and is used to adjust the frequency of the radio frequency signal output by the radio frequency source.

6. A method for collecting magnetic resonance signals, characterized in that: Applied to the integrated magnetic resonance spectroscopy device according to any one of claims 1 to 5, the method comprises: The control unit controls the microwave source to output a microwave signal, and controls the radio frequency source to output a radio frequency signal; The microwave signal output by the microwave source is transmitted to the probe and acts on the test sample, and the radio frequency signal output by the radio frequency source is transmitted to the electron-nuclear double resonance coil of the probe and acts on the test sample; The paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample; The nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample.

7. The magnetic resonance signal acquisition method according to claim 6, characterized in that: The method further comprises: The control unit controls the microwave source to output a microwave signal; The microwave signal output by the microwave source is transmitted to the probe and acts on the test sample; The paramagnetic resonance signal receiving and processing system receives and processes the paramagnetic resonance signal fed back by the test sample.

8. The magnetic resonance signal acquisition method according to claim 6, characterized in that: The method further comprises: The control unit controls the radio frequency source to output a radio frequency signal; The radio frequency signal output by the radio frequency source is transmitted to the electron-nuclear double resonance coil of the probe and acts on the test sample; The nuclear magnetic resonance signal receiving and processing system receives and processes the nuclear magnetic resonance signal fed back by the test sample.

9. The magnetic resonance signal acquisition method according to any one of claims 6 to 8, characterized in that: The method further comprises: The frequency adjustment unit is adjusted so that the RF source outputs a RF signal at a target RF frequency.

10. The magnetic resonance signal acquisition method according to any one of claims 6 to 8, characterized in that: The method further comprises: Adjust the temperature control unit to bring the temperature of the probe to the target temperature.

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