Red ginseng extract special care essence and preparation method thereof

Abstract

The invention provides a red ginseng extract special care essence and a preparation method thereof, and a red ginseng extract composition. The red ginseng extract composition comprises a red ginseng extract, deer bone collagen peptide, a red camellia extract, beta-nicotinamide mononucleotide, a rose extract, a moutan bark extract and a ligusticum wallichii extract. According to the invention, the red ginseng extract, the deer bone collagen peptide, the red camellia flower extract, the beta-nicotinamide mononucleotide, the rose flower extract, the moutan bark extract and the ligusticum wallichii extract are adopted, so that the prepared special care essence with the red ginseng extract has better oxidation resistance and aging resistance.

Description

Technical Field

[0001] The invention relates to the technical field of skin care essence, and more specifically, to a red ginseng extract special care essence and a preparation method thereof. Background Art

[0002] In recent years, with the changes in climate and environment, the damage to the skin has increased, and therefore, people's demand and requirements for skin care products have become higher and higher.

[0003] At present, skin care products containing plant active ingredients are favored by consumers because of their mild effects, small side effects, and easy absorption of components compared with traditional cosmetics. For example, chamomile has significant antioxidant capacity, which can enhance the skin's moisturizing ability, prevent skin dryness, and enhance the skin barrier function. It is widely used for sensitive skin; the extract of Pleurotus citrinum is rich in ergothioneine and other small molecule effective ingredients. These substances can effectively penetrate into skin cells, be fully absorbed and utilized by cells, and play physiological functions such as nourishing the skin, removing free radicals and inhibiting tyrosinase.

[0004] In the Chinese invention patent CN109464342B, an anti-aging essence is disclosed, which includes the following components in mass percentage: 0.01-2% active peptide, 3-15% polyol, 0.01-10% moisturizer, 0.5-1.2% plant preservative, 0.1-10% skin conditioner, 0.02-0.1% chelating agent, 0.1-2% anti-inflammatory repair agent and the balance deionized water. The invention also provides a preparation method of the above anti-aging essence and its application in the preparation of skin care products. The anti-aging essence of the invention can be used for daily skin care, and has the effects of moisturizing, anti-inflammatory and soothing, reducing wrinkles, and brightening skin color. At the same time, the use of natural plant preservatives solves the inactivation problem when the active peptides and traditional chemical preservatives are compatible, and ensures the stability of the product function. However, the invention does not use the overall component combination of natural plants themselves, and preservatives are added. Compared with products with no added preservatives, the friendliness still needs to be improved. Therefore, it is urgent to seek safer, gentler and more effective skin care essences.

[0005] In the Chinese invention patent application document with the publication number of CN111643427A, an anti-aging composition, an anti-aging cosmetic and a preparation method thereof are disclosed, wherein an anti-aging composition, by mass, comprises the following components: 0.125-0.375 parts of red ginseng extract, 1.0-4.0 parts of ginseng root water, 0.05-0.2 parts of turmeric root extract, 0.02-0.2 parts of Cistanche deserticola extract, 0.02-0.2 parts of Dendrobium officinale stem extract, 0.02-0.2 parts of Ganoderma lucidum extract, 0.02-0.2 parts of Poria cocos extract, 0.02-0.2 parts of Cornus officinalis extract, 0.02-0.2 parts of Tripterygium wilfordii extract, and 0.02-0.2 parts of Polygonum cuspidatum root extract. It has good antioxidant properties and the effect of activating cells, can prevent skin aging, and can effectively improve the aging condition of the skin, and has excellent anti-aging effects. Summary of the invention

[0006] In view of the deficiencies in the prior art, the present invention provides a red ginseng extract special care essence and a preparation method thereof.

[0007] In a first aspect, the present invention provides a red ginseng extract composition, comprising red ginseng extract, deer bone collagen peptide, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract.

[0008] Preferably, the red ginseng extract composition comprises, by mass, 1.5-3.8 parts of red ginseng extract, 0.1-1.2 parts of deer bone collagen peptide, 0.5-1.5 parts of red camellia extract, 0.8-1.6 parts of β-nicotinamide mononucleotide, 0.2-1.5 parts of rose extract, 0.5-1.8 parts of peony bark extract and 0.1-2.1 parts of ligusticum chuanxiong extract.

[0009] Preferably, the red ginseng extract composition comprises, by mass, 1.8-3.2 parts of red ginseng extract, 0.6-1.2 parts of deer bone collagen peptides, 0.8-1.2 parts of red camellia extract, 0.8-1.0 parts of β-nicotinamide mononucleotide, 0.6-1.1 parts of rose extract, 0.8-1.2 parts of peony bark extract and 0.5-1.5 parts of chuanxiong extract.

[0010] Preferably, among the above ingredients, red ginseng extract may be 1.5 parts, 1.8 parts, 2.1 parts, 2.5 parts, 2.8 parts, 3.2 parts, and 3.8 parts; deer bone collagen peptide may be 0.1 parts, 0.5 parts, 0.8 parts, 0.9 parts, 1.0 parts, 1.1 parts, and 1.2 parts; red camellia extract may be 0.5 parts, 0.8 parts, 0.9 parts, 1.0 parts, 1.2 parts, 1.4 parts, and 1.5 parts; β-nicotinamide mononucleotide may be 0.8 parts, The amounts of rose extract can be 0.2, 0.5, 0.8, 0.9, 1.0, 1.2, 1.5, and 1.6 parts; the amounts of peony bark extract can be 0.5, 0.8, 0.9, 1.0, 1.2, 1.5, and 1.8 parts; the amounts of chuanxiong extract can be 0.1, 0.5, 0.8, 1.0, 1.2, 1.5, and 2.1 parts.

[0011] Preferably, the preparation method of the red ginseng extract is: crush the red ginseng slices, weigh the red ginseng powder, add boiling water and cook for 3-5 hours, take the supernatant, add macroporous resin D101, stir at room temperature for adsorption purification, filter and collect the D101 resin, add propylene glycol, stir and mix evenly, stir and desorb at 50-80°C, collect the filtrate, centrifuge the filtrate, and collect the supernatant, i.e., the red ginseng extract.

[0012] Preferably, the preparation method of deer bone collagen peptide is: (1) Raw material pretreatment: First, the deer bones need to be pretreated, including removing impurities such as residual meat, fascia, blood, and bone marrow on the surface, and crushing and cleaning the deer bones.

[0013] (2) Extraction of collagen: Collagen in deer bones can be extracted by enzymatic hydrolysis, using specific enzymes pepsin and trypsin to hydrolyze collagen.

[0014] (3) Enzymatic hydrolysis process: During the enzymatic hydrolysis process, deer bone collagen is mixed with enzymes, and the pH is adjusted to 3-6 and the temperature is 0-25°C so that the enzymes can effectively hydrolyze the collagen into small molecule peptides.

[0015] (4) Filtration and separation: The mixture after enzymatic hydrolysis needs to be filtered and separated to remove unhydrolyzed macromolecules and other impurities.

[0016] (5) Concentration and drying: The filtered solution needs to be concentrated to remove excess water; then, the concentrated solution is converted into collagen peptides in powder form through a drying method to obtain deer bone collagen peptides.

[0017] Preferably, the preparation method of red camellia extract is: extraction by ultrasound-assisted extraction, firstly ultrasonic extraction of camellia, then reaction of the extract with a metal ion complexing agent to obtain precipitate A; then, the precipitate A is sequentially dissolved and extracted to finally obtain the camellia extract.

[0018] Preferably, the preparation method of β-nicotinamide mononucleotide is: using tetraacetyl ribose and nicotinate ethyl ester as starting materials, and preparing β-nicotinamide mononucleotide through condensation, deacetylation of protecting groups, aminolysis, activated carbon chromatography separation and phosphorylation.

[0019] Preferably, the preparation method of rose extract is: subjecting rose to low-temperature vacuum extraction, with a vacuum degree of -70 to -90 kPa, an extraction temperature of 40 to 60°C, and an extraction time of 4.5 to 5.5 hours. Thereafter, rose water is obtained by filtration, and rose stamens are further extracted using rose water and glycerin as an extractant to obtain the final rose extract.

[0020] Preferably, the preparation method of the peony bark extract is: extracting the peony bark medicinal material with an organic alcohol aqueous solution, and then concentrating and drying to obtain the peony bark extract.

[0021] Preferably, the preparation method of the Chuanxiong extract is: using 90% ethanol to reflux extract Chuanxiong, each extraction time is 179 minutes, and then recovering the ethanol and vacuum drying to obtain the Chuanxiong extract.

[0022] In a second aspect, the present invention provides a red ginseng extract special care essence, which is prepared using the red ginseng extract composition according to claims 1 to 3, an emulsifier, a polyol, a phospholipid and water.

[0023] In a third aspect, the present invention provides a method for preparing a red ginseng extract special care essence, comprising the following steps: (1) mixing a red ginseng extract, a red camellia extract, β-nicotinamide mononucleotide, a rose extract, a peony bark extract and a ligusticum chuanxiong extract with a polyol, a phospholipid and water to obtain a mixed solution A; (2) mixing deer bone collagen peptide, an emulsifier and a polyol to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0024] Preferably, in step (1), the polyol includes at least one of glycerol, propylene glycol, butylene glycol, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, dipropylene glycol, isopropanol, polyethylene glycol-200, PPG-10 sorbitol, and octyldodecanol; The phospholipids include at least one of sphingomyelin, phosphatidylcholine and soybean phosphatidylcholine.

[0025] Preferably, in step (1), the mixing temperature is 60-80°C, and the stirring is performed at 150-200 rpm for 10-30 min.

[0026] Preferably, in step (2), the emulsifier includes at least one of polyoxyethylene castor oil emulsifier, polyoxyethylene hydrogenated castor oil emulsifier, and coconut glucoside; Preferably, in step (2), the mixing temperature is 40-70° C. and the stirring is performed at 200-270 rpm for 10-30 min.

[0027] In summary, the present invention has the following beneficial effects: 1. The chemical components of the red ginseng extract of the present invention are mainly saponins, volatile oils, sugars, amino acids, trace elements, etc. The pharmacological effects mainly include enhancing immunity, anti-tumor, anti-oxidation, anti-aging, anti-fatigue, anti-diabetes, anti-hepatorenal toxicity, etc. Red ginseng can play an anti-aging effect by regulating oxygen free radicals in the body, improving the body's immune function and weakening the inflammatory state, and the anti-aging effect is related to the expression of TNF-, GPX1, GPX2, IL-1, IL-6 and IL-10. The red ginseng polysaccharide alcohol extract has the strongest antioxidant effect; 2. The red ginseng extract and β-nicotinamide mononucleotide in the present invention cooperate with each other and have better pharmacological activity of scavenging free radicals and anti-oxidation. The red ginseng extract mainly exerts its effects through the anti-oxidation mechanism, while NMN delays aging through multiple pathways such as increasing NAD+ levels, promoting cell energy conversion and repairing gene damage; 3. The peony bark of the present invention contains paeonol, paeonol, paeoniflorin and sugar compounds, and has strong antibacterial, anti-inflammatory, antioxidant and moisturizing effects, and also has certain anti-allergic, anti-tumor, blood circulation improvement, nerve protection and other effects; Chuanxiong is rich in volatile oils, polysaccharide compounds, and a variety of amino acids and ceramide compounds, and has whitening, moisturizing, antibacterial, anti-inflammatory, anti-tumor and other effects; Chuanxiong and Angelica have the effects of promoting blood circulation, removing blood stasis, and relieving pain; 4. The present invention adopts red ginseng extract, deer bone collagen peptide, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and Chuanxiong extract, so that the prepared red ginseng extract special care essence has good antioxidant and anti-aging properties.

[0028] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not intended to limit the scope of protection of the present invention. DETAILED DESCRIPTION

[0029] The present invention is further described in detail below in conjunction with the examples. It is particularly noted that if no specific conditions are specified in the following examples, the reactions are carried out according to conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the raw materials used in the following examples can be obtained from common commercial sources. Example

[0030] Example 1

[0031] A red ginseng extract composition, comprising 1.5 parts of red ginseng extract, 0.1 parts of deer bone collagen peptide, 0.5 parts of red camellia extract, 0.8 parts of β-nicotinamide mononucleotide, 0.2 parts of rose extract, 0.5 parts of peony bark extract and 0.1 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:2:2; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:2.

[0032] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a mixing temperature of 60° C. and stirring at 150 rpm for 10 min to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and polyol at 40° C. and stirring at 200 rpm for 10 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0033] Example 2

[0034] A red ginseng extract composition, comprising 1.8 parts of red ginseng extract, 0.5 parts of deer bone collagen peptide, 0.8 parts of red camellia extract, 0.9 parts of β-nicotinamide mononucleotide, 0.5 parts of rose extract, 0.8 parts of peony bark extract and 0.5 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:2:3; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:3.

[0035] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a mixing temperature of 70°C and stirring at 200 rpm for 30 min to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and polyol at a temperature of 50° C. and stirring at 200 rpm for 20 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0036] Example 3

[0037] A red ginseng extract composition, comprising 2.1 parts of red ginseng extract, 0.8 parts of deer bone collagen peptide, 0.9 parts of red camellia extract, 1.0 parts of β-nicotinamide mononucleotide, 0.8 parts of rose extract, 0.9 parts of peony bark extract and 0.8 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:1:1; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:2.

[0038] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a temperature of 80°C and stirring at 200 rpm for 30 min to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and polyol at 70° C. and stirring at 270 rpm for 30 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0039] Example 4

[0040] A red ginseng extract composition, comprising 2.5 parts of red ginseng extract, 1.0 part of deer bone collagen peptide, 1.0 part of red camellia extract, 1.2 parts of β-nicotinamide mononucleotide, 0.9 part of rose extract, 1.0 part of peony bark extract and 1.0 part of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:2:1; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:3.

[0041] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a temperature of 70°C and stirring at 200 rpm for 20 min to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and polyol at 60° C. and stirring at 270 rpm for 20 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0042] Example 5

[0043] A red ginseng extract composition, comprising 2.8 parts of red ginseng extract, 1.0 part of deer bone collagen peptide, 1.2 parts of red camellia extract, 1.4 parts of β-nicotinamide mononucleotide, 1.0 part of rose extract, 1.2 parts of peony bark extract and 1.2 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:2:2; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:2.

[0044] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a mixing temperature of 80° C. and stirring at 180 rpm for 10 min to obtain a mixed solution A; (2) Mixing deer bone collagen peptide, emulsifier and polyol at 60° C. and stirring at 270 rpm for 10 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0045] Example 6

[0046] A red ginseng extract composition, comprising 3.2 parts of red ginseng extract, 1.1 parts of deer bone collagen peptide, 1.4 parts of red camellia extract, 1.5 parts of β-nicotinamide mononucleotide, 1.2 parts of rose extract, 1.5 parts of peony bark extract and 1.5 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:1:1; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:3.

[0047] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a temperature of 60°C and stirring at 200 rpm for 10 min to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and polyol at 40° C. and stirring at 270 rpm for 30 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0048] Example 7

[0049] A red ginseng extract composition, comprising 3.8 parts of red ginseng extract, 1.2 parts of deer bone collagen peptide, 1.5 parts of red camellia extract, 1.6 parts of β-nicotinamide mononucleotide, 1.5 parts of rose extract, 1.8 parts of peony bark extract and 2.1 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 1:2:1; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 1:1.

[0050] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a temperature of 80°C and stirring at 200 rpm for 30 min to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and polyol at 70° C. and stirring at 270 rpm for 30 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

[0051] Example 8

[0052] A red ginseng extract composition, comprising 3.8 parts of red ginseng extract, 1.2 parts of deer bone collagen peptide, 1.5 parts of red camellia extract, 1.6 parts of β-nicotinamide mononucleotide, 1.4 parts of rose extract, 1.6 parts of peony bark extract and 1.8 parts of chuanxiong extract, wherein the red ginseng extract is a red ginseng polysaccharide alcohol extract; A red ginseng extract special care essence, prepared from the above red ginseng extract composition, an emulsifier, a polyol, a phospholipid and water; The polyol is a mixture of butanediol, polyethylene glycol-200, and PPG-10 sorbitol in a mass ratio of 2:2:1; The phospholipid is sphingomyelin; and the emulsifier is a mixture of polyoxyethylene castor oil emulsifier and coconut glucoside in a mass ratio of 2:1.

[0053] A method for preparing a red ginseng extract special care essence comprises the following steps: (1) Mixing red ginseng extract, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and ligusticum chuanxiong extract with polyol, phospholipid and water at a temperature of 60°C and stirring at 200 rpm for 10 min to obtain a mixed solution A; (2) Mixing deer bone collagen peptide, emulsifier and polyol at 70° C. and stirring at 270 rpm for 10 min to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence. Comparative Example

[0054] Comparative Example 1 Compared with Example 1, the difference is that red ginseng extract is not contained, and other ingredients are the same.

[0055] Comparative Example 2 Compared with Example 1, the difference is that deer bone collagen peptide is not contained, and other ingredients are the same.

[0056] For this example 3 Compared with Example 1, the difference is that the red camellia extract is not contained, and the other ingredients are the same.

[0057] Comparative Example 4 Compared with Example 1, the difference is that rose extract is not contained, and other ingredients are the same.

[0058] Comparative Example 5 Compared with Example 1, the difference is that β-nicotinamide mononucleotide is not contained, and other ingredients are the same.

[0059] Comparative Example 6 Compared with Example 1, the difference is that: Chuanxiong extract is not contained, and other ingredients are the same.

[0060] Performance Evaluation The red ginseng extract special care essence obtained in Examples 1-8 and Comparative Examples 1-5 was subjected to physical and chemical property performance tests, sensitivity tests, and antioxidant tests.

[0061] Physical and chemical properties test The appearance, pH and relative density of the product were measured; the appearance of the product was measured by sensory method, and the pH was measured by pH meter. The relative density was measured as follows: (1) Weigh the mass of the dry empty bottle with a balance and record it as m1 (g); (2) Fill the bottle with the liquid of the relative density to be measured and plug it with a stopper; wipe the surface of the bottle with a cloth or absorbent paper; weigh it again and record it as m2 (g); (3) Pour out the liquid in the bottle and wash it with clean water; (4) Fill the empty bottle with water, plug it with a stopper and wipe the surface of the bottle; weigh it again and record it as m3 (g); (5) Calculate using the following formula. The density of the liquid to be measured relative to water is ρrelative=(m2-m1) / (m3-m1); The test results obtained according to the above steps are shown in Table 1.

[0062] Table 1. Physical and chemical properties of red ginseng extract special care essence prepared in Examples 1-8 and Comparative Examples 1-5

[0063] The test results are shown in Table 1. Through Examples 1-8 and Comparative Examples 1-5, it can be understood that the use of red ginseng extract, deer bone collagen peptide, red camellia extract, β-nicotinamide mononucleotide, rose extract, peony bark extract and Chuanxiong extract makes the pH value of each component 6.0-6.8 under the synergistic effect of the components. The pH value is an important indicator for measuring the pH value of skin care products and is crucial to skin health. The surface of healthy skin is usually weakly acidic. The appearance of skin care products usually includes color, smell and texture. These factors not only affect the sensory experience of consumers, but also may affect the acceptance and use effect of the product. Relative density is an important performance indicator of liquid cosmetics, which reflects the concentration and texture of the product. High-density skin care products usually contain higher concentrations of active ingredients and provide better skin care effects.

[0064] 2. Sensitivity test The red ginseng extract special care essence samples of Examples 1-8 and Comparative Examples 1-5 were tested for their ability to alleviate skin irritation.

[0065] The specific test methods are as follows: (1) Select appropriate people for patch testing. The subjects cannot have scars, scars or excessive hair on their skin. Those with a known history of severe allergies or severe allergies to cosmetics cannot participate; (2) Use the test product on sensitive areas; (3) Evaluation indicators of skin tolerance at the test site: itching, tightness, irritation, redness, and dryness; The index levels are as follows: Level 0: no allergic reaction; Level 1: slight erythema, dry skin, wrinkles; Level 2: erythema, a lot of red blood; Level 3: large area of ​​burning, broken skin. The results obtained by the above method are shown in Table 2.

[0066] Table 2. Sensitivity test of red ginseng extract special care essence prepared in Examples 1-8 and Comparative Examples 1-5

[0067] 3. Antioxidant test: DPPH free radical scavenging Test sample: Red ginseng extract special care essence prepared in Examples 1-8 and Comparative Examples 1-5, prepare 0.1mmol / L DPPH test solution, add 0.5mL 2% concentration of red ginseng extract special care essence prepared in Examples 1-4 and Comparative Examples 1-5 respectively. After fully mixing, let stand in the dark for 30min, use anhydrous ethanol as a blank control, measure the absorbance at 517nm, and calculate the scavenging rate of 2% concentration of each sample for DPPH according to the following formula. The calculation formula is: ; Wherein: A2: absorbance of the reaction system of the composition and DPPH; A1: absorbance of anhydrous ethanol of the composition; A0: absorbance of anhydrous ethanol of the blank control.

[0068] Superoxide radical Determination of scavenging ability: Examples 1-8 and Comparative Examples 1-5 were used as the test solution, 1 mL of the test solution was accurately drawn, 4.5 mL of 50 mmol / L Tris-HCl buffer solution with a pH of 8.2 was added, and then mixed. After keeping warm for 20 minutes, 0.3 mL of 25 mmol / L pyrogallol solution was immediately added, and the mixture was reacted in a 25°C constant temperature water bath for 5 minutes after being quickly shaken. 1 mL of 8 mmol / L HCl was then added, and the reaction was terminated after mixing. The absorbance was measured at 325 nm, and distilled water was used instead of the sample as a blank control. Vc was used as a positive control. Each sample was measured in parallel 3 times, and the average value was taken.

[0069] The clearance rate was calculated according to formula (2) and recorded in Table 3 below.

[0070] Where: A0 is the average absorbance of the blank; A1 is the average absorbance of the liquid to be tested.

[0071] Determination of hydroxyl radical scavenging ability Examples 1-8 and Comparative Examples 1-5 were used as the test solution, 1 mL 0.15 mmol / L FeSO4, 0.4 mL 2 mmol / L salicylic acid, 0.2 mL test solution, 1 mL 6 mmol / L H2O2 and 0.4 mL distilled water were added to the test tubes of the sample group; the blank group used distilled water instead of the test solution, and the control group used distilled water instead of salicylic acid, and reacted at 37°C for 30 minutes. Vc was used as a positive control. Each sample was measured in parallel 3 times, and the average value was taken.

[0072] The hydroxyl radical scavenging capacity was calculated according to formula (3) and recorded in Table 3 below.

[0073]

[0074] Table 3 shows the scavenging of DPPH free radicals and superoxide free radicals Test results of scavenging ability and scavenging hydroxyl free radical ability.

[0075] Table 3. Antioxidant test of red ginseng extract special care essence prepared in Examples 1-8 and Comparative Examples 1-5

[0076] As shown in Table 2, the scavenging rates of the red ginseng extract special care essence prepared in Examples 1-8 for DPPH free radicals, superoxide anion free radicals and hydroxyl free radicals are significantly higher than those in Comparative Examples 1-5. The scavenging rates of the red ginseng extract special care essence prepared in Examples 1-8 are 91.6%-96.1%, the scavenging rates of superoxide anion free radicals are 75.9-79.1%, and the scavenging rates of hydroxyl free radicals are 80.9-85.3%, while the scavenging rates of the red ginseng extract antioxidant essence prepared in Comparative Examples 1-5 for DPPH free radicals are 60.9%-76.5%, the scavenging rates of superoxide anion free radicals are 43.9-47.5%, and the scavenging rates of hydroxyl free radicals are 50.1-54.3%. In summary, it is shown that the composition containing multiple plant natural ingredients provided by the present invention has good antioxidant capacity, can improve the degradation of cell structure function under the action of excessive free radicals, and is conducive to promoting skin barrier repair.

[0077] 4. Moisturizing ability test of red ginseng extract special care essence Experimental conditions: The test environment temperature is 20℃, the relative humidity is 45-55%, and the same indoor lighting conditions are maintained for real-time dynamic monitoring.

[0078] Preparation before the test: Four groups of volunteers were selected, aged 20-45 years old, and the test skin was non-traumatic. No cosmetics or topical drugs should be used on the test area 2-3 days before the test. Before the test, the subjects need to clean the test area. After cleaning, multiple areas can be marked at the same time, with at least 1cm between each test area. The basic data is measured after sitting quietly in a constant temperature and humidity environment for 30 minutes. During this period, water and beverages cannot be consumed. The subjects are placed in a test state and remain relaxed.

[0079] Methods and steps: Refer to the evaluation method of QB / T4256-2011 Cosmetic Moisturizing Efficacy Evaluation Guide.

[0080] ① The test sample is coated once at a certain amount, and the sample is evenly coated in the test area using a latex finger cot, and the actual coating amount is recorded.

[0081] ② The skin analysis tester measures the test area, and each area is measured at least 3 times in parallel. First measure the initial value of each test area (before the sample is used), and then test the skin moisture content of the test area after a set time.

[0082] ③Measure the skin moisture content of the test area 1h, 2h and 4h after application. The test of the same subject must be completed by the same measurement personnel using the same instrument, and the measurement probe should be cleaned between two measurements.

[0083] The experimental results are shown in Table 4: Table 4 Effect of red ginseng extract special care essence on skin moisture content

[0084] It can be found from the experimental data in Table 4 that the red ginseng extract special care essence prepared in Examples 1-8 has a significant moisturizing effect after 1 hour of use, and can still achieve a significant moisturizing effect until 4 hours later, and the maintenance time is relatively long. Compared with the red ginseng extract special care essence prepared in Comparative Examples 1-5, the moisturizing rate is significantly improved.

[0085] The above is only an exemplary embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A red ginseng extract composition, characterized in that: The invention comprises the following components by weight: 1.5-3.8 parts of red ginseng extract, 0.1-1.2 parts of deer bone collagen peptide, 0.5-1.5 parts of red camellia extract, 0.8-1.6 parts of beta-nicotinamide mononucleotide, 0.2-1.5 parts of rose extract, 0.5-1.8 parts of peony bark extract and 0.1-2.1 parts of chuanxiong extract.

2. The red ginseng extract composition according to claim 1, characterized in that The invention comprises the following components by weight: 1.8-3.2 parts of red ginseng extract, 0.6-1.2 parts of deer bone collagen peptide, 0.8-1.2 parts of red camellia extract, 0.8-1.0 parts of beta-nicotinamide mononucleotide, 0.6-1.1 parts of rose extract, 0.8-1.2 parts of peony bark extract and 0.5-1.5 parts of chuanxiong extract.

3. The red ginseng extract composition according to claim 1, characterized in that The preparation method of the red ginseng extract is as follows: crushing red ginseng slices, weighing red ginseng powder, boiling it in boiling water for 3-5 hours, taking the supernatant, adding macroporous resin D101, stirring at room temperature for adsorption purification, filtering and collecting the D101 resin, adding propylene glycol, stirring and mixing evenly, stirring and desorbing at 50-80° C., collecting the filtrate, centrifuging the filtrate, and collecting the supernatant, i.e., the red ginseng extract.

4. A red ginseng extract special care essence, characterized in that: The invention is prepared by using the red ginseng extract composition described in claims 1 to 3, an emulsifier, polyols, phospholipids and water.

5. The method for preparing the red ginseng extract special care essence according to claim 4, characterized in that: The following steps are involved: (1) mixing a red ginseng extract, a red camellia extract, β-nicotinamide mononucleotide, a rose extract, a peony bark extract and a ligusticum chuanxiong extract with a polyol, a phospholipid and water to obtain a mixed solution A; (2) mixing deer bone collagen peptide, emulsifier and water to obtain a mixed solution B; (3) The mixed solution A obtained in step (1) and the mixed solution B obtained in step (2) are mixed evenly to obtain a red ginseng extract special care essence.

6. The method for preparing the red ginseng extract special care essence according to claim 5, characterized in that: In step (1), the polyol includes at least one of glycerol, propylene glycol, butylene glycol, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, dipropylene glycol, isopropanol, polyethylene glycol-200, PPG-10 sorbitol, and octyldodecanol; The phospholipids include at least one of sphingomyelin, phosphatidylcholine and soybean phosphatidylcholine.

7. The method for preparing the red ginseng extract special care essence according to claim 5, characterized in that: In step (1), the mixing temperature is 60-80°C, and the stirring is performed at 150-200 rpm for 10-30 min.

8. The method for preparing the red ginseng extract special care essence according to claim 5, characterized in that: In step (2), the emulsifier includes at least one of polyoxyethylene castor oil emulsifier, polyoxyethylene hydrogenated castor oil emulsifier and coconut glucoside.

9. The method for preparing the red ginseng extract special care essence according to claim 5, characterized in that: In step (2), the temperature during mixing is 40-70° C. and the stirring is performed at 200-270 rpm for 10-30 min.

Images