Traditional Chinese medicine composition for treating middle-term fracture and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating middle-term fracture and application thereof, and the traditional Chinese medicine composition is composed of native copper, ground beeltle, frankincense, myrrh, dragon's blood, pseudo-ginseng, radix aconiti preparata, dragon bone, safflower, teasel root, crab, rhizoma drynariae, raw rhizoma cyperi, sappan wood, corydalis tuber, borneol, raw radix angelicae and herba lycopi. The medicine is applied reasonably and dialectically, and the hematoma organizational stage (early stage) is as follows: due to qi stagnation and blood stasis, local swelling and heavy pain, the medicine pays attention to promoting blood circulation to remove blood stasis and relieving swelling and pain; (and) blood stasis and swelling in the callus formation stage (middle stage) are relieved but not completely removed, and medication pays attention to new bone reunion; in a callus remodeling stage (later stage), the medicine is mainly used for continuing muscles and bones and tonifying the liver and kidney, and is also used for warming and activating meridians, so that the pain of a patient can be greatly relieved, the disease course is shortened, and the rehabilitation quality is improved; the traditional Chinese medicine composition is reasonable in medicine compatibility, can be used for promoting blood circulation, diminishing swelling and relieving pain, and can be used for reunion of fractured bones and tendons, relaxing tendons and activating collaterals at the same time and achieve mutual consideration and tonification and purgation at the same time when blood stasis and swelling pain in the middle stage of fracture are not completely removed and muscles and bones are not firmly connected.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating mid-stage fractures and application thereof. Background Art

[0002] Fracture is a common clinical disease. Traditional Chinese medicine divides fracture healing into three stages: hematoma organization stage (early stage), callus formation stage (middle stage), and callus remodeling stage (late stage). The first stage of hematoma organization usually forms 2-3 weeks after fracture. During fracture, due to the destruction of bone tissue, the periosteum and surrounding soft tissue are also damaged and torn, accompanied by a large amount of bleeding, filling the tissues at both ends of the fracture and around it to form a hematoma. Generally, within a few hours, the hematoma will coagulate, and some inflammatory cells will infiltrate. The hematoma gradually organizes to form granulation tissue, and further develops into fibrous connective tissue; the second stage of callus formation is about 3-7 weeks after the fracture, including two processes, fibrous callus formation stage and bony callus formation stage. Within 2-3 days of the fracture, the proliferating fibroblasts and capillaries of the endosteal and periosteum enter the hematoma, promoting the hematoma to become fibrous callus. As the fracture healing progresses, bone cells will produce new bone, gradually replacing the fibrous callus, thereby forming some bone-like tissue and forming bony callus. As calcium salts are deposited, the cartilage tissue in the fibrous callus will gradually transform into bone tissue and participate in the formation of bone callus. However, these structures are not dense enough, the arrangement of trabeculae is relatively chaotic, and they cannot meet the requirements of normal function; ③ Callus remodeling period: about 8-12 weeks after the fracture, mainly refers to the irregular arrangement of bone callus at the fracture ends gradually connecting, in order to meet physiological requirements and achieve a gradually firm structure and function, the bone callus will further become mature lamellar bone and cortical bone, and the normal relationship with the medullary cavity will be restored, and the medullary cavity will be unobstructed, and the fracture will be completely healed. Different healing periods in the process of fracture healing require syndrome differentiation and treatment. There are some drugs on the market for the treatment of fractures, but there is no syndrome differentiation and treatment for different stages of fracture healing, and the effect is not ideal. Summary of the invention

[0003] Therefore, based on the above background, the present invention, on the basis of the ancestral formula, has been continuously improved and applied, and finally formed a medicine for syndrome differentiation and treatment at different stages of fracture healing. The syndrome differentiation and treatment have significant therapeutic effects, especially the traditional Chinese medicine and its application for the middle stage of fracture.

[0004] A Chinese medicine composition for treating mid-stage fractures, comprising the following raw materials in parts by weight:

[0005] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of eruo (processed), 8-20 parts of dragon bone, 3-10 parts of safflower, 8-20 parts of dipsaccharum, 10-30 parts of crab, 5-15 parts of drynaria, 5-15 parts of raw cyperus, 5-15 parts of Sappan wood, 5-15 parts of Corydalis, 8-20 parts of borneol, 10-20 parts of raw angelica, and 5-15 parts of zedoaria.

[0006] Based on the same inventive concept, the present invention also provides the use of the above-mentioned Chinese medicine composition for treating mid-stage fractures in the preparation of a drug for treating mid-stage fractures, wherein the drug also includes a medically acceptable adjuvant, and the drug is an oral preparation or an external preparation.

[0007] Furthermore, the oral preparation can be a decoction, a mixture, a decoction, a wine, a tincture, a powder, a honey pill, a granule, a capsule, or a tablet.

[0008] Furthermore, the external preparation is a plaster or a spray.

[0009] Based on the same inventive concept, the present invention also provides the use of the above-mentioned Chinese medicine composition for treating mid-stage fracture in the preparation of a medicine for treating fracture.

[0010] Furthermore, the medicine for treating fractures is composed of the first Chinese medicine composition, the above-mentioned Chinese medicine composition for treating mid-term fractures, the second Chinese medicine composition, the third Chinese medicine composition, and the fourth Chinese medicine composition;

[0011] in:

[0012] The first Chinese medicine composition is composed of the following raw materials in parts by weight:

[0013] 8-20 parts of Phellodendron amurense, 5-15 parts of Eupolyphaga sinensis, 8-20 parts of Phellodendron chinense, 8-20 parts of Rhubarb, 8-20 parts of Coptis chinensis, 8-20 parts of Scutellaria baicalensis, 8-20 parts of Dipsacus asper, 5-15 parts of Corydalis yanhusuo, 5-15 parts of Lycopodiella cuneata, 5-15 parts of Drynaria fortunei, 5-15 parts of Myrrha, 5-15 parts of Frankincense, 3-10 parts of Zedoariae rhizome, 3-10 parts of Sappan wood, and 3-10 parts of Borneolum;

[0014] The second Chinese medicine composition is composed of the following raw materials in parts by weight:

[0015] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of erhusuo, 8-20 parts of angelica (washed with wine), 3-10 parts of dodder seeds (processed with salt), 3-10 parts of oxalis, 3-10 parts of zelan, 8-20 parts of sappan wood, 5-15 parts of millettia reticulata, 5-15 parts of mistletoe (steamed), 8-20 parts of borneol, 10-20 parts of raw angelica, 10-20 parts of raw cyperus;

[0016] The third Chinese medicine composition is composed of the following raw materials in parts by weight:

[0017] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of eriocarpus (processed), 8-20 parts of salvia miltiorrhiza, 8-20 parts of angelica (washed with wine), 3-10 parts of oxalis, 3-10 parts of centipede, 3-10 parts of ligusticum chuanxiong, 8-20 parts of sappan wood, 3-10 parts of corydalis, 8-20 parts of borneol, 8-20 parts of raw cyperus, 10-20 parts of raw angelica;

[0018] The fourth Chinese medicine composition is composed of the following raw materials in parts by weight:

[0019] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of Panax notoginseng, 3-10 parts of eriocarpus (processed), 3-10 parts of artificial musk, 3-10 parts of safflower, 3-10 parts of menthol, 8-20 parts of angelica, 8-20 parts of Corydalis, 8-20 parts of Sappan wood, 8-20 parts of borneol, and 3-10 parts of raw Cyperus rotundus.

[0020] The two Wu in the above Chinese medicine composition is the collective name for the two Chinese medicines Wu and Chuanwu.

[0021] Furthermore, the second Chinese medicine composition is an oral preparation.

[0022] Furthermore, the first and third Chinese medicine compositions are external preparations, and the fourth Chinese medicine composition is an alcoholic preparation.

[0023] Furthermore, the fourth Chinese medicine composition is used to prepare the first Chinese medicine composition.

[0024] The beneficial effects achieved by the present invention are as follows:

[0025] According to the different stages of fracture healing, the present invention uses drugs composed of multiple Chinese medicine compositions, and rationally and dialectically applies drugs. (Elimination) hematoma organization stage (early stage): due to qi stagnation and blood stasis, local swelling and severe pain, the drug application focuses on promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and the first Chinese medicine composition is used for treatment; (Harmony) callus formation stage (middle stage) although blood stasis and swelling are alleviated, they are not completely eliminated, the drug application focuses on harmonizing and reconnecting bones and tendons, and the Chinese medicine composition for treating middle stage fracture of the present invention is used for treatment; (Replenishment) callus remodeling stage (late stage) focuses on connecting tendons and bones, tonifying the liver and kidney, and warming the meridians and unblocking collaterals, which can greatly relieve the patient's pain, shorten the course of the disease, and improve the quality of rehabilitation, and the second Chinese medicine composition and the third Chinese medicine composition are used for treatment; in particular, the Chinese medicine composition for the middle stage of fracture is rationally compatible with drugs, and the blood stasis, swelling and pain in the middle stage of fracture have not been completely eliminated, and the connection between tendons and bones is not yet solid, which can realize the simultaneous use of promoting blood circulation, reducing swelling and relieving pain, connecting bones and tendons, and relaxing tendons and activating collaterals, taking into account each other, and attacking and replenishing at the same time. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] The present invention provides a Chinese medicine composition for treating mid-stage fracture, which is composed of the following raw materials in parts by weight:

[0028] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of eruo (processed), 8-20 parts of dragon bone, 3-10 parts of safflower, 8-20 parts of dipsaccharum, 10-30 parts of crab, 5-15 parts of drynaria, 5-15 parts of raw cyperus, 5-15 parts of Sappan wood, 5-15 parts of Corydalis, 8-20 parts of borneol, 10-20 parts of raw angelica, and 5-15 parts of zedoaria.

[0029] Among the Chinese herbal medicine compositions for the mid-term treatment of fractures, Xuejie promotes blood circulation and relieves pain, removes blood stasis and stops bleeding; Panax notoginseng disperses blood stasis and stops bleeding, reduces swelling and relieves pain; Safflower promotes blood circulation and regulates menstruation, disperses blood stasis and relieves pain; Natural copper disperses blood and relieves pain, sets bones and heals injuries; Fanghai nourishes the kidney and replenishes essence, disperses blood stasis and reduces swelling; Longgu relieves pain, disperses blood stasis, calms the nerves and stops convulsions; Drynaria promotes blood circulation and heals injuries and relieves pain, nourishes the kidney and strengthens bones; Dipsacus asper nourishes the liver and kidney, strengthens tendons and bones, and heals fractures; Corydalis promotes blood circulation and promotes qi, and relieves pain; Eupolyphaga sinensis breaks up blood circulation, removes blood stasis, heals tendons and sets bones; Myrrh disperses blood, removes blood stasis, relieves pain and reduces swelling; Frankincense promotes blood circulation, relieves pain and reduces swelling; Zedoaria promotes blood circulation, removes blood stasis and reduces swelling; Sappan promotes blood circulation, removes blood stasis, reduces swelling and relieves pain; Cyperus rotundus regulates menstruation and relieves pain; Angelica dahurica removes dampness and relieves pain; Borneol clears heat and relieves pain. The invention uses natural copper, earthworm and frankincense as main drugs, myrrh, dragon blood, notoginseng and two black as assistant drugs, dragon bone, safflower, Dipsacus asafoetida, crab and Drynariae rhizoma as adjuvant drugs, and uses Su Mu, Corydalis yanhusuo, Borneolum, 10-20 parts of raw Angelica dahurica and Zedoariae rhizoma as guiding drugs. The notoginseng and safflower are used together to promote blood circulation and dissipate blood stasis, and relieve pain; the natural copper is used together to fix bones and tendons; the Drynariae rhizoma and dragon bone are used together with frankincense and myrrh to promote blood circulation and dissipate blood stasis, reduce swelling and relieve pain, and fix tendons and bones ; Dipsacus asper and Rhizoma Coptidis are combined with Sophora japonica, which has the effects of long-lasting sweetness, warming, nourishing, and strengthening bones and tendons; Cyperus rotundus is combined with Corydalis yanhusuo, which is good at nourishing blood and activating blood circulation; Xuejie is combined with frankincense and myrrh, which is good at activating blood circulation and qi, and treating bruises and blood stasis and pain; Angelica dahurica is combined with Zedoariae rhizome, which is pungent, dispersing, warming, and has a mild and not strong medicinal property; Sophora japonica and Eupolyphaga sinensis are combined, which can disperse the qi to relax the tendons and activate the collaterals, reduce swelling and relieve pain, and treat bruises, bruises, swelling and pain. All the medicines are used together to achieve the effects of activating blood circulation and relieving pain, and connecting bones and tendons.

[0030] In the above composition:

[0031] Xue Jie: It is made from the resin exuded from the fruit of the palm plant Qilinjie. It tastes bitter and flat. It enters the heart and liver meridians, promotes blood circulation and relieves pain, removes blood stasis and stops bleeding, promotes tissue regeneration and heals sores. It has the effects of astringing and stopping bleeding, promoting tissue regeneration and heals sores when used externally. It can be used for traumatic bleeding, hemorrhoids, and intestinal wind, and can be ground into powder and applied externally to the affected area. It also has the effect of stopping bleeding when taken internally, such as treating upper gastrointestinal bleeding. It is often used for traumatic injuries, heart and abdominal pain, traumatic bleeding, and sores that do not heal.

[0032] Panax notoginseng is the dried root and rhizome of Panax notoginseng of the Araliaceae family. It is sweet and warm. It enters the liver and stomach meridians. It can disperse blood stasis and stop bleeding, reduce swelling and relieve pain. It is used for hemoptysis, vomiting blood, standing blood, blood in the stool, metrorrhagia, bleeding from trauma, stabbing pain in the chest and abdomen, and swelling and pain from falls.

[0033] Safflower is the dried flower of the safflower plant of the Asteraceae family. It is pungent and warm. It enters the heart and liver meridians. It promotes blood circulation and menstruation, dissipates blood stasis and relieves pain. It is used for amenorrhea, dysmenorrhea, lochia retention, scars and lumps, chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and ribs, injuries from falls, and swelling and pain in sores.

[0034] Natural copper is a sulfide mineral belonging to the pyrite family, and its main component is iron disulfide (FeS2). Pungent and neutral. It belongs to the liver meridian. It can dissipate blood stasis, relieve pain, and heal injuries. It is used for symptoms such as traumatic injuries, fractures and tendon breaks, and bruises and pain.

[0035] Crab is also known as Fanghai, which is salty and cold. It enters the liver, stomach, heart, kidney and pericardium meridians. It disperses blood, clears heat and disperses blood stasis.

[0036] Dragon bone tastes astringent, sweet, and neutral. It enters the heart, liver, kidney, and large intestine meridians. It calms the mind, soothes the liver and suppresses yang, consolidates and stops nocturnal emission, promotes tissue regeneration and heals sores.

[0037] Drynaria fortunei: It is the dried rhizome of Drynaria fortunei (Kunze) J.Sm., a plant of the Polypodiaceae family. It tastes bitter and warm. It enters the liver and kidney meridians. It can heal wounds and relieve pain, nourish the kidney and strengthen bones; it can be used externally to eliminate wind and remove spots. It can be used for falls, sprains, fractures of tendons and bones, low back pain due to kidney deficiency, weakness of tendons and bones, tinnitus, deafness, loose teeth; it can also be used externally to treat alopecia areata and vitiligo.

[0038] Dipsacus asperWall.exHenry: It is the dried root of Dipsacus asperWall.exHenry, a plant of the Dipsacus family. It is bitter, pungent, and slightly warm. It enters the liver and kidney meridians. It nourishes the liver and kidney, strengthens the tendons and bones, heals fractures, and stops metrorrhagia. It is used for liver and kidney deficiency, soreness of the waist and knees, rheumatism, injuries from falls, fractures caused by tendons, metrorrhagia, and miscarriage. Dipsacus in wine is mostly used for rheumatism, injuries from falls, fractures caused by tendons. Dipsacus in salt is mostly used for soreness of the waist and knees.

[0039] Angelica sinensis: It is the dried root of Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family. It is sweet, pungent, and warm. It enters the liver, heart, and spleen meridians. It nourishes blood and promotes blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. It is used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, asthenic abdominal pain, rheumatic arthralgia, injuries from falls, carbuncles, ulcers, and constipation caused by dry intestines. Wine-boiled Angelica sinensis promotes blood circulation and promotes menstruation. It is used for amenorrhea and dysmenorrhea, rheumatic arthralgia, and injuries from falls.

[0040] Corydalis yanhusuo: It is the dried tuber of Corydalis yanhusuo W.T. Wang, a plant of the Poppy family. It is pungent, bitter, and warm. It enters the liver and spleen meridians. It promotes blood circulation, promotes qi, and relieves pain. It is used for chest, flank, and abdominal pain, chest obstruction and heart pain, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain caused by falls.

[0041] Eupolyphagasinensis Walker: The dried body of the female Eupolyphagasinensis Walker or Steleophagaplancyi (Boleny), an insect of the family Blattidae. Salty, cold, slightly toxic. Enters the liver meridian. It can break blood and remove blood stasis, and heal tendons and bones. It is used for traumatic injuries, tendon injuries and fractures, blood stasis and amenorrhea, abdominal pain due to blood stasis after childbirth, and lumps and masses.

[0042] Myrrh: It is the dried resin of Commiphora myrrha Engl. or Commiphora molmol Engl., plants of the olive family. Pungent, bitter, neutral. It enters the heart, liver, and spleen meridians. It can dissipate blood stasis, relieve pain, and promote tissue regeneration. It is used for chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to lumps, rheumatic pain, traumatic injuries, carbuncle, swelling, and ulcers.

[0043] Frankincense: It is the resin exuded from the bark of Boswellia carterii Birdw. and Boswellia bhaw-dajiana Birdw., both of which are plants of the same genus. It is pungent, bitter, and warm. It enters the heart, liver, and spleen meridians. It promotes blood circulation, relieves pain, and promotes tissue regeneration. It is used for chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to lumps, rheumatic pain, muscle spasms, injuries from falls, and carbuncles and ulcers.

[0044] Ze Lan: It is the dried aerial part of Lycopus lucidus Turcz. var. hirtus Regel, a plant of the Labiatae family. It tastes bitter, pungent, and slightly warm. It enters the liver and spleen meridians. It activates blood circulation and regulates menstruation, removes blood stasis and eliminates carbuncle, and promotes diuresis and reduces swelling. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain caused by blood stasis after childbirth, swelling caused by carbuncle, edema and ascites.

[0045] Sappan: It is the dried heartwood of Caesalpiniasappan L., a plant of the Leguminosae family. It is sweet, salty, and neutral. It enters the heart, liver, and spleen meridians. It promotes blood circulation, removes blood stasis, and relieves swelling and pain. It is used for traumatic injuries, fractures, tendon injuries, stasis, swelling and pain, amenorrhea, dysmenorrhea, postpartum blood stasis, chest and abdominal pain, and swelling and pain caused by carbuncle.

[0046] The above Chinese medicine composition can be added with medically acceptable auxiliary materials to prepare an external preparation.

[0047] The oral preparation or external preparation can be one of powder, pill, wine, tincture, paste, plaster, aerosol, spray, powder spray, and film.

[0048] The present invention also provides a medicine for treating fractures, which performs syndrome differentiation and treatment according to different times of fracture healing, and is composed of a first Chinese medicine composition, the above-mentioned Chinese medicine composition for treating mid-term fractures, a second Chinese medicine composition, a third Chinese medicine composition, and a fourth Chinese medicine composition;

[0049] The first Chinese medicine composition is composed of the following raw materials in parts by weight:

[0050] 8-20 parts of Phellodendron amurense, 5-15 parts of Eupolyphaga sinensis, 8-20 parts of Phellodendron chinense, 8-20 parts of Rhubarb, 8-20 parts of Coptis chinensis, 8-20 parts of Scutellaria baicalensis, 8-20 parts of Dipsacus asper, 5-15 parts of Corydalis yanhusuo, 5-15 parts of Lycopodiella cuneata, 5-15 parts of Drynaria fortunei, 5-15 parts of Myrrha, 5-15 parts of Frankincense, 3-10 parts of Zedoariae rhizome, 3-10 parts of Sappan wood, and 3-10 parts of Borneolum;

[0051] The first Chinese medicine composition has Phellodendron chinense, Eupolyphaga sinensis, and Phellodendron chinense as main drugs, Rhubarb, Coptis chinensis, Scutellaria baicalensis, and Dipsacus as assistant drugs, Corydalis yanhusuo, Lycopodiella cuneata, Drynaria fortunei, Myrrh, and Olibanum as adjuvant drugs, and Zedoaria zedoariae, Sappan wood, and Borneol as guiding drugs;

[0052] The second Chinese medicine composition is composed of the following raw materials in parts by weight:

[0053] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of erhusuo, 8-20 parts of angelica (washed with wine), 3-10 parts of dodder seeds (processed with salt), 3-10 parts of oxalis, 3-10 parts of zelan, 8-20 parts of sappan wood, 5-15 parts of millettia reticulata, 5-15 parts of mistletoe (steamed), 8-20 parts of borneol, 10-20 parts of raw angelica, 10-20 parts of raw cyperus;

[0054] The second Chinese medicine composition has natural copper, earthworm, and frankincense as main drugs, myrrh, dragon's blood, notoginseng, and eruo (processed) as assistant drugs, corydalis, angelica (washed with wine), dodder seed (processed with salt), oxalis, and zelan as adjuvant drugs, and sappan wood, millet vine, mistletoe (steamed), borneol, raw angelica, and raw cyperus as guiding drugs;

[0055] The third Chinese medicine composition is composed of the following raw materials in parts by weight:

[0056] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of eriocarpus (processed), 8-20 parts of salvia miltiorrhiza, 8-20 parts of angelica (washed with wine), 3-10 parts of oxalis, 3-10 parts of centipede, 3-10 parts of ligusticum chuanxiong, 8-20 parts of sappan wood, 3-10 parts of corydalis, 8-20 parts of borneol, 8-20 parts of raw cyperus, 10-20 parts of raw angelica;

[0057] The third Chinese medicine composition uses natural copper, earthworm and frankincense as main drugs, myrrh, blood clotting, notoginseng and eruo as assistant drugs, salvia miltiorrhiza, angelica (washed with wine), oxalis, centipede and ligusticum chuanxiong as adjuvant drugs, and sappan wood, corydalis, borneol, raw cyperus and raw angelica as guiding drugs;

[0058] The fourth Chinese medicine composition is composed of the following raw materials in parts by weight:

[0059] 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of Panax notoginseng, 3-10 parts of eriocarpus (processed), 3-10 parts of artificial musk, 3-10 parts of safflower, 3-10 parts of menthol, 8-20 parts of angelica, 8-20 parts of Corydalis, 8-20 parts of Sappan wood, 8-20 parts of borneol, and 3-10 parts of raw Cyperus rotundus.

[0060] In the fourth Chinese medicine composition, natural copper, earthworm and frankincense are the main drugs, myrrh, dragon's blood, notoginseng and two black (processed) are the assistant drugs, artificial musk, safflower, menthol, angelica and corydalis are the adjuvant drugs, and sappan wood, borneol and raw cyperus are the guiding drugs;

[0061] The second Chinese medicine composition is an oral preparation. The third Chinese medicine composition is an external ointment, and the first Chinese medicine composition is an external powder.

[0062] The fourth Chinese medicine composition is an alcoholic drink, and the first and fourth Chinese medicine compositions are used together. Specifically, the fourth Chinese medicine composition in the form of an alcoholic drink is used to prepare the first Chinese medicine composition for external application to treat the early stages of fractures, and the second and third Chinese medicine compositions are used to treat the late stages of fractures.

[0063] Example 1: A Chinese medicine composition for treating mid-stage fracture, which is prepared from the following raw materials in parts by weight:

[0064] 8 parts of natural copper (calcined), 5 parts of earthworms, 8 parts of frankincense, 8 parts of myrrh, 8 parts of blood clotting, 8 parts of Panax notoginseng, 3 parts of two black (processed), 8 parts of dragon bones, 8 parts of safflower, 20 parts of Dipsacus asper, 10 parts of Rhizoma Anemarrhenae, 15 parts of Drynariae Rhizoma, 5 parts of raw Cyperus rotundus, 10 parts of Sappan wood, 15 parts of Corydalis yanhusuo, 8 parts of borneol, 10 parts of raw Angelica dahurica, and 5 parts of Herba Lycopodiellae.

[0065] Its preparation comprises the following steps:

[0066] (1) Natural copper (calcined) 8g, earthworm 5g, frankincense 8g, myrrh 8g, blood clotting 8g, Panax notoginseng 8g, two black (processed) 3g, dragon bone 8g, safflower 8g, Dipsacus asper 20g, Fang Hai 10g, Drynaria 15g, raw Cyperus rotundus 5g, Sappan wood 10g, Corydalis 15g, borneol 8g, raw Angelica dahurica 10g, Zedoaria 5g;

[0067] (2) Processing the above raw materials (except for Eupolyphaga sinensis, myrrh, and frankincense): cutting Rhizoma Drynariae, Radix Dipsaci, Rhizoma Corydalis, and Sanguisorba officinalis into 4 mm thick slices, cutting Herba Lycopodii into 10 mm segments, and crushing Sappanwood Powder, Radix Adenophorae, Coptis Chinensis, Rhizoma Cyperi, Radix Angelicae Dahuricae, Borneolum, and Rhizoma Aconiti Lateralis into coarse powder; placing the processed raw materials, Eupolyphaga sinensis, myrrh, and frankincense into a decoction container;

[0068] (3) Add 850 ml of cold water, soak for 1.5 hours, heat to boiling over high heat, simmer over low heat for 1 hour, and filter to obtain a filtrate; repeat 3 times, combine the filtrates, and obtain a Chinese medicine composition.

[0069] Example 2: A Chinese medicine composition for treating mid-stage fracture, which is prepared from the following raw materials in parts by weight:

[0070] 8 parts of natural copper (calcined), 12 parts of earthworms, 12 parts of frankincense, 12 parts of myrrh, 8 parts of Sanguisorba officinalis, 8 parts of Panax notoginseng, 5 parts of Erwu (processed), 8 parts of dragon bones, 8 parts of safflower, 8 parts of Dipsacus asper, 10 parts of Rhizoma Anemarrhenae, 8 parts of Drynariae Rhizoma, 5 parts of raw Cyperus rotundus, 15 parts of Sappan wood, 8 parts of Corydalis yanhusuo, 8 parts of Borneolum, 10 parts of raw Angelica dahurica, and 8 parts of Herba Lycopodiellae.

[0071] Its preparation comprises the following steps:

[0072] (1) Take 8g of natural copper (calcined), 12g of earthworm, 12g of frankincense, 12g of myrrh, 8g of blood clotting, 8g of Panax notoginseng, 5g of processed radix aconiti lobata, 8g of dragon bone, 8g of safflower, 8g of Dipsacus asper, 10g of Radix Achyranthis Bidentatae, 8g of Drynariae Rhizoma, 5g of raw Cyperus rotundus, 15g of Sappan wood, 8g of Corydalis yanhusuo, 8g of borneol, 10g of raw Angelica dahurica, and 8g of Zedoariae rhizoma;

[0073] (2) Processing the above raw materials (except for Eupolyphaga sinensis, myrrh, and frankincense): cutting Rhizoma Drynariae, Radix Dipsaci, Rhizoma Corydalis, and Sanguisorba officinalis into 4 mm thick slices, cutting Herba Lycopodii into 10 mm segments, and crushing Sappanwood Powder, Radix Adenophorae, Coptis Chinensis, Rhizoma Cyperi, Radix Angelicae Dahuricae, Borneolum, and Rhizoma Aconiti Lateralis into coarse powder; placing the processed raw materials, Eupolyphaga sinensis, myrrh, and frankincense into a decoction container;

[0074] (3) Add 850 ml of cold water, soak for 1.5 hours, heat to boiling over high heat, simmer over low heat for 1 hour, and filter to obtain a filtrate; repeat 3 times, combine the filtrates, and obtain a Chinese medicine composition.

[0075] Example 3: A Chinese medicine composition for treating mid-stage fracture, which is prepared from the following raw materials in parts by weight:

[0076] 8 parts of natural copper (calcined), 10 parts of earthworms, 10 parts of frankincense, 10 parts of myrrh, 8 parts of Sanguisorba officinalis, 8 parts of Panax notoginseng, 8 parts of Wu (processed), 8 parts of dragon bones, 8 parts of safflower, 15 parts of Dipsacus asper, 15 parts of Rhizoma Anemarrhenae, 15 parts of Drynariae Rhizoma, 10 parts of raw Cyperus rotundus, 10 parts of Sappan wood, 10 parts of Corydalis yanhusuo, 8 parts of borneol, 10 parts of raw Angelica dahurica, and 10 parts of Herba Lycopodiellae.

[0077] Its preparation comprises the following steps:

[0078] (1) Take 8g of natural copper (calcined), 10g of earthworm, 10g of frankincense, 10g of myrrh, 8g of blood clotting, 8g of Panax notoginseng, 8g of processed radix aconiti lateralis, 8g of dragon bone, 8g of safflower, 15g of Dipsacus asper, 15g of Rhizoma Achyranthis Bidentatae, 10g of raw Cyperus rotundus, 10g of Sappan wood, 10g of Corydalis yanhusuo, 8g of borneol, 10g of raw Angelica dahurica, and 10g of Zedoariae rhizome.

[0079] (2) Processing the above raw materials (except for Eupolyphaga sinensis, myrrh, and frankincense): cutting Rhizoma Drynariae, Radix Dipsaci, Rhizoma Corydalis, and Sanguisorba officinalis into 3 mm thick slices, cutting Herba Lycopodii into 15 mm segments, and crushing Sappanwood Powder, Radix Adenophorae, Coptis Chinensis, Rhizoma Cyperi, Radix Angelicae Dahuricae, Borneolum, and Rhizoma Aconiti Lateralis into coarse powder; placing the processed raw materials, Eupolyphaga sinensis, myrrh, and frankincense into a decoction container;

[0080] (3) Add 900 ml of cold water, soak for 1 hour, heat to boiling over high heat, simmer over low heat for 1 hour, and filter to obtain a filtrate; repeat 3 times, combine the filtrates, and obtain a Chinese medicine composition.

[0081] Example 4: A Chinese medicine composition for treating mid-stage fracture, which is prepared from the following raw materials in parts by weight:

[0082] 8 parts of natural copper (calcined), 10 parts of earthworms, 8 parts of frankincense, 10 parts of myrrh, 8 parts of blood clotting, 8 parts of Panax notoginseng, 10 parts of two black (processed), 8 parts of dragon bones, 8 parts of safflower, 15 parts of Dipsacus asper, 8 parts of Rhizoma Anemarrhenae, 15 parts of Drynariae Rhizoma, 10 parts of raw Cyperus rotundus, 5 parts of Sappan wood, 5 parts of Corydalis yanhusuo, 8 parts of borneol, 10 parts of raw Angelica dahurica, and 10 parts of Herba Lycopodiellae.

[0083] Its preparation comprises the following steps:

[0084] (1) Take 8g of natural copper (calcined), 10g of earthworm, 8g of frankincense, 10g of myrrh, 8g of blood clotting, 8g of Panax notoginseng, 10g of processed radix aconiti lateralis, 8g of dragon bone, 8g of safflower, 15g of Dipsacus asper, 8g of Radix Achyranthis Bidentatae, 15g of Drynariae Rhizoma, 10g of raw Cyperus rotundus, 5g of Sappan wood, 5g of Corydalis yanhusuo, 8g of borneol, 10g of raw Angelica dahurica, and 10g of Zedoariae rhizoma;

[0085] (2) Processing the above raw materials (except for Eupolyphaga sinensis, myrrh, and frankincense): cutting Rhizoma Drynariae, Radix Dipsaci, Rhizoma Corydalis, and Sanguisorba officinalis into 3 mm thick slices, cutting Herba Lycopodii into 10 mm segments, and crushing Sappanwood Powder, Radix Adenophorae, Coptis Chinensis, Rhizoma Cyperi, Radix Angelicae Dahuricae, Borneolum, and Rhizoma Aconiti Lateralis into coarse powder; placing the processed raw materials, Eupolyphaga sinensis, myrrh, and frankincense into a decoction container;

[0086] (3) Add 780 ml of cold water, soak for 1.5 hours, heat to boiling over high heat, simmer over low heat for 1 hour, and filter to obtain a filtrate; repeat 4 times, combine the filtrates, and obtain a Chinese medicine composition.

[0087] Example 5: A Chinese medicine composition for treating mid-stage fracture, which is prepared from the following raw materials in parts by weight:

[0088] 8 parts of natural copper (calcined), 15 parts of earthworms, 15 parts of frankincense, 15 parts of myrrh, 8 parts of Sanguisorba officinalis, 8 parts of Panax notoginseng, 10 parts of Erwu (processed), 8 parts of dragon bones, 8 parts of safflower, 20 parts of Dipsacus asper, 8 parts of Rhizoma Anemarrhenae, 18 parts of Drynariae Rhizoma, 10 parts of raw Cyperus rotundus, 12 parts of Sappan wood, 10 parts of Corydalis yanhusuo, 8 parts of borneol, 10 parts of raw Angelica dahurica, and 15 parts of Herba Lycopodiellae.

[0089] Its preparation comprises the following steps:

[0090] (1) Take 8g of natural copper (calcined), 15g of earthworm, 15g of frankincense, 15g of myrrh, 8g of blood clotting, 8g of Panax notoginseng, 10g of processed radix aconiti lateralis, 8g of dragon bone, 8g of safflower, 20g of Dipsacus asper, 8g of Radix Achyranthis Bidentatae, 18g of Drynariae Rhizoma, 10g of raw Cyperus rotundus, 12g of Sappan wood, 10g of Corydalis yanhusuo, 8g of borneol, 10g of raw Angelica dahurica, and 15g of Zedoariae rhizoma;

[0091] (2) Processing the above raw materials (except for Eupolyphaga sinensis, myrrh, and frankincense): cutting Rhizoma Drynariae, Radix Dipsaci, Rhizoma Corydalis, and Sanguisorba officinalis into 3 mm thick slices, cutting Herba Lycopodii into 12 mm segments, and crushing Sappanwood, Radix Achyranthis Bidentatae, Coptis Chinensis, Cyperus rotundus, Angelica dahurica, Borneolum, and Rhizoma Aconiti Lateralis into coarse powder; placing the processed raw materials, Eupolyphaga sinensis, myrrh, and frankincense into a decoction container;

[0092] (3) Add 820 ml of cold water, soak for 1 hour, heat to boiling over high heat, simmer over low heat for 1 hour, and filter to obtain a filtrate; repeat twice, combine the filtrates, and obtain a Chinese medicine composition.

[0093] Example 6: A Chinese medicine composition for treating mid-stage fracture, which is prepared from the following raw materials in parts by weight:

[0094] 8 parts of natural copper (calcined), 10 parts of earthworms, 10 parts of frankincense, 10 parts of myrrh, 8 parts of Sanguisorba officinalis, 8 parts of Panax notoginseng, 10 parts of Erwu (processed), 8 parts of dragon bones, 8 parts of safflower, 15 parts of Dipsacus asper, 8 parts of Rhizoma Anemarrhenae, 15 parts of Drynariae Rhizoma, 10 parts of raw Cyperus rotundus, 10 parts of Sappan wood, 10 parts of Corydalis yanhusuo, 8 parts of borneol, 10 parts of raw Angelica dahurica, and 10 parts of Herba Lycopodiellae.

[0095] Its preparation comprises the following steps:

[0096] (1) Take 8g of natural copper (calcined), 10g of earthworm, 10g of frankincense, 10g of myrrh, 8g of Sanguisorba officinalis, 8g of Panax notoginseng, 10g of Wu (processed), 8g of dragon bone, 8g of safflower, 15g of Dipsacus asper, 8g of Rhizoma Anemarrhenae, 15g of Drynariae, 10g of raw Cyperus rotundus, 10g of Sappan wood, 10g of Corydalis yanhusuo, 8g of borneol, 10g of raw Angelica dahurica, and 10g of Zedoariae rhizome.

[0097] (2) Processing the above raw materials (except for Eupolyphaga sinensis, myrrh, and frankincense): cutting Rhizoma Drynariae, Radix Dipsaci, Rhizoma Corydalis, and Sanguisorba officinalis into 3 mm thick slices, cutting Herba Lycopodii into 10 mm segments, and crushing Sappanwood, Radix Achyranthis Bidentatae, Coptis Chinensis, Rhizoma Cyperi, Radix Angelicae Dahuricae, Borneolum, and Rhizoma Aconiti Lateralis into coarse powder; placing the processed raw materials, Eupolyphaga sinensis, myrrh, and frankincense into a decoction container;

[0098] (3) Add 800 ml of cold water, soak for 1.5 hours, heat to boiling over high heat, simmer over low heat for 1 hour, and filter to obtain a filtrate; repeat 4 times, combine the filtrates, and obtain a Chinese medicine composition.

[0099] Example 7: A decoction for treating mid-stage fractures, the preparation steps of which are as follows:

[0100] The decoction prepared in Example 1 (step 3) was filtered, and the filtrate was concentrated to 300 ml to obtain a decoction.

[0101] Example 8: A mixture for treating mid-stage fractures, the preparation steps of which are as follows:

[0102] 1) After filtering the decoction prepared in Example 3, the filtrate was concentrated to a clear paste with a relative density of 1.18 to 1.22 (65° C.);

[0103] 2) Add ethanol to make the alcohol content reach 65% and let it stand for 24 hours;

[0104] 3) filtering, recovering ethanol, and concentrating to a thick paste (65° C.) with a relative density of 1.26 to 1.30;

[0105] 4) Add 0.5 g sodium benzoate and 6 g sucrose, add water to 160 ml, filter, fill, sterilize, and obtain a mixture.

[0106] Example 9: A decoction for treating mid-stage fractures, the preparation steps of which are as follows:

[0107] 1) filtering the decoction obtained in Example 2, and concentrating the filtrate to a clear paste with a relative density of 1.21 to 1.25 (70° C.);

[0108] 2) Take brown sugar (the mass is twice that of the clear paste);

[0109] 3) Heat the brown sugar over direct fire and continue to stir until it turns yellow, add the clear paste, and continue to concentrate until the relative density is 1.4 (70°C) to obtain a decoction paste.

[0110] Example 10: A wine preparation for treating mid-stage fractures, the preparation steps are as follows:

[0111] 1) Take the raw materials according to the Chinese medicine combination of Example 5, mix them, grind them into powder, add them into a mixture of 1200 ml of white wine and 4000 ml of yellow wine, and soak them for 48 hours;

[0112] 2) Slowly percolate and collect the percolate;

[0113] 3) Add 450 g of sucrose, stir to dissolve, let stand, filter, and obtain the wine.

[0114] Example 11: A tincture for treating mid-stage fractures, the preparation steps of which are as follows:

[0115] 1) Take the raw materials of the Chinese medicine combination of Example 5, mix them, grind them into powder, add them into 4000 ml of 70% ethanol and soak them for 24 hours;

[0116] 2) Slowly percolate, collect the percolate to 1500 ml, stir well, and obtain tincture.

[0117] Example 12: A black plaster for treating mid-stage fractures, the preparation steps of which are as follows:

[0118] 1) Take the raw materials according to the Chinese medicine combination of Example 6, mix them, grind them into powder, add them to 700g edible vegetable oil, fry them in a pot until they are dry, remove the residue, filter them, and refine them until water drops into beads;

[0119] 2) Take 220g of red lead, add it to the oil, stir well, collect the paste, and soak the paste in water;

[0120] 3) Take the paste, melt it over a low flame, and spread it on a cloth to obtain a black plaster.

[0121] Example 13: A powder for treating mid-stage fractures, the preparation steps of which are as follows:

[0122] The raw materials were taken according to the Chinese medicine combination of Example 5, mixed, and ground into 100 mesh powder to obtain a powder.

[0123] Example 14: A honey pill for treating mid-stage fracture, the preparation steps of which are as follows:

[0124] 1) taking raw materials according to the Chinese medicine combination of Example 6, mixing them, and grinding them into 100 mesh fine powder;

[0125] 2) Add refined honey (the mass is 1.2 times the mass of the fine powder) to make honey pills.

[0126] Example 15: A granule for treating mid-stage fracture, the preparation steps of which are as follows:

[0127] 1) filtering the decoction obtained in Example 4, and concentrating the filtrate to a relative density of 1.20 (50° C.);

[0128] 2) Add ethanol to make the alcohol content reach 60%, stir, and let stand for 24 hours;

[0129] 3) Take the supernatant, recover ethanol, concentrate to a clear paste with a relative density of 1.35-1.40 (50°C), dry under reduced pressure and then grind;

[0130] 4) Take 1 part of dry extract powder, 4.5 parts of sucrose and 1.5 parts of dextrin, mix well, moisten with ethanol and granulate, dry at 75°C and granulate to obtain granules.

[0131] Example 16: A capsule for treating mid-stage fractures, the preparation steps of which are as follows:

[0132] The granules obtained in Example 14 were filled into capsules to obtain capsules.

[0133] Example 17: A tablet for treating mid-stage fractures, the preparation steps of which are as follows:

[0134] The granules obtained in Example 14 were compressed into tablets to obtain tablets.

[0135] Example 18: A spray for treating mid-stage fractures, the preparation steps of which are as follows:

[0136] 1) taking the raw materials according to the Chinese medicine combination of Example 6, mixing them, grinding them into powder, and immersing them in 75% ethanol twice, each time for 48 hours;

[0137] 2) Collect 200 ml of the impregnation solution in total, filter and obtain a filtrate;

[0138] 3) Add borneol (the mass is 0.5% of the mass of the filtrate), stir evenly, seal, let stand for 24 hours, and fill to obtain a spray.

[0139] Clinical validation data:

[0140] 238 cases in the middle stage of fracture were randomly selected, aged 16-52 years old, including 117 males and 121 females. The above patients were treated with the honey pills in the above embodiment. The effective dosage of the honey pills was 3g / pill, once in the morning and evening twice a day, 3-5 pills each time, and the treatment lasted for 4 weeks.

[0141] The case selection and efficacy judgment criteria refer to the "Guidelines for Clinical Research of New Chinese Medicines" issued by the China Medical Science and Technology Bureau in 2002. Cases: All met the case selection criteria. Efficacy: Marked effect means that the clinical healing time of fractures is shortened by ≥1 / 3; effective means that the clinical healing time of fractures is shortened by ≥1 / 5, <1 / 3; ineffective means that the above standards are not met. Healing time standard control: the average value of the reference value of clinical healing time of common fractures in adults.

[0142] The results are shown in the table below:

[0143] Case classification Significant effect efficient invalid Efficiency male 117 19 13 91％ female 121 22 8 94.7％

[0144] Typical cases are as follows:

[0145] Case 1: Deng, female, 65 years old. T6 vertebral compression fracture, T8 vertebral compression fracture, severe chest and back pain. Oral administration of the honey pills prepared in Example 14 relieved the pain after 1 week, and the affected area was basically healed after 3 weeks, and moderate activities were allowed.

[0146] Case 2: Mr. Wu, male, 23 years old. Fracture of the lower part of the right tibia, fracture of the right lateral malleolus, severe pain in the right ankle, obvious swelling, hard to the touch, and purple color. After external application of the decoction prepared in Example 9, the pain was mild and tolerable after 2 weeks, and the swelling was soft to the touch and light in color. After 4 weeks, the affected area was basically healed and the patient could walk.

[0147] Case 3: Yin, male, 56 years old. Fracture of right scapula (scapular spine), pain, swelling and bruise in right shoulder. Oral administration of the mixture prepared in Example 8 showed that the pain and swelling were relieved after 1 week, and the affected area was basically healed after 2 weeks.

[0148] Case 4: Fu, male, 40 years old. He suffered from right subtrochanteric fracture, unbearable pain in the right hip, severe swelling and bruising. He took the powder prepared in Example 11 orally, and the pain was relieved after 1 week, and the swelling subsided and the bruising was absorbed after 2 weeks. The affected area was basically healed and he could move moderately.

[0149] Case 5: Ding, female, 64 years old. Distal right radius fracture, right ulnar styloid avulsion fracture, right wrist pain and swelling. The black plaster prepared in Example 12 was applied externally. After 2 weeks, the pain was significantly relieved, the swelling was mild, and the affected area was basically healed.

[0150] Case 6: Mr. Lu, male, 68 years old. Comminuted fracture of right tibial intercondylar spine, pain, swelling and bruise in right knee. Oral administration of the honey pills prepared in Example 14 relieved the pain, subsided the swelling, absorbed the bruise and the affected area was basically healed after 2 weeks.

[0151] Case 7: Qin, male, 61 years old. Left medial malleolus fracture, left lateral malleolus avulsion fracture, unbearable pain in the left ankle, severe swelling. The wine prepared in Example 10 was applied externally, and the pain was significantly relieved after 1 week, and the swelling was slight after 2 weeks, and the affected area was basically healed.

[0152] Case 2: Yang, male, 68 years old. Left clavicle fracture, left shoulder pain, swelling, bruise. Oral administration of the mixture prepared in Example 8 relieved the pain, subsided the swelling, absorbed the bruise, and the affected area was basically healed after 2 weeks.

[0153] Case 8: Chen, male, 40 years old. Multiple rib fractures on the left side (7th to 12th rib fractures), unbearable pain in the left chest and back. Oral administration of the granules prepared in Example 15 relieved the pain after 1 week, and after 2 weeks, the pain subsided, the affected area was basically healed, and moderate activities were possible.

[0154] Case 9: Wang, female, 38 years old. Fracture of the first and fifth metatarsal bones of the left foot, severe pain and swelling in the left foot. After taking the decoction prepared in Example 9 orally, the pain was significantly relieved, the swelling was mild, the affected area was basically healed, and she could try to walk.

[0155] Case 10: Pan, female, 58 years old. Left distal radius fracture, left ulnar styloid fracture, left wrist pain and swelling. Oral administration of the decoction prepared in Example 7 relieved the pain after 1 week, and the swelling subsided after 2 weeks, and the affected area was basically healed.

[0156] Case 11: Dai, male, 46 years old. He had fractures of the 11th and 12th ribs on the right side, unbearable pain in the right chest and back, and pale complexion. He took the capsule prepared in Example 16 orally, and the pain was mild and his complexion was pale after 1 week. After 2 weeks, the affected area was basically healed, and he could move moderately and his complexion was normal.

[0157] Case 12: Mr. Wang, male, 54 years old. He suffered from multiple rib fractures on the left side, pain in the left chest and back, and dry mouth. He took the decoction prepared in Example 7 orally. After one week, the pain was mild and the mouth was slightly dry. After two weeks, the affected area was basically healed and he could move moderately.

[0158] Case 13: Cai, female, 60 years old. Multiple right rib fractures (9-12 ribs on the right side) and pain in the right chest and back. After taking the tablets prepared in Example 17 orally for one week, the pain was significantly relieved, the affected area was basically healed, and moderate activities were possible.

[0159] Case 14: Zhang, male, 54 years old. Left fibula fracture, left calf pain and swelling. After external application of the tincture prepared in Example 11, the pain was significantly relieved and the swelling was mild after 1 week. After 3 weeks, the swelling disappeared, the affected area was basically healed, and the patient could try to walk.

[0160] Case 15: Zheng, male, 56 years old. Left subtrochanteric fracture, left hip pain, swelling, cyanosis. Oral administration of the decoction prepared in Example 7 relieved pain, subsided swelling, and lightened color after 1 week. After 2 weeks, the affected area was basically healed and could try to walk.

[0161] Case 16: Fu, male, 63 years old. Left scapula fracture, left shoulder pain, swelling, bruise. After external application of the black plaster prepared in Example 12, the pain was relieved, the swelling subsided, the bruise was absorbed, the affected area was basically healed, and moderate activities were allowed.

[0162] Case 17: Lu, male, 52 years old. Fracture of ribs 3-7 on the right side, pain in the right chest and back, and weakness in the limbs. After taking the tablets prepared in Example 17 orally, the pain was relieved after 1 week, and he felt slightly weak. After 3 weeks, the affected area was basically healed.

[0163] Case 18: Dai, female, 51 years old. Left distal radius comminuted fracture, left wrist pain and swelling. After external application of the spray prepared in Example 18, the pain was significantly relieved and the swelling was mild after 1 week. After 2 weeks, the affected part of the left wrist was basically healed and could be moderately active.

[0164] Case 19: Wang, male, 25 years old. Left distal radius fracture, left ulnar styloid avulsion fracture, unbearable pain in the left wrist, severe swelling. The spray prepared in Example 18 was applied externally, and the pain was significantly relieved and the swelling was light after 1 week. After 2 weeks, the affected part of the left wrist was basically healed and could be moved appropriately.

[0165] The present invention and its implementation methods are described above, and such description is not restrictive, and the actual methods are not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design implementation methods and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating mid-stage fracture, characterized in that: It is composed of the following raw materials in parts by weight: 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of eruo (processed), 8-20 parts of dragon bone, 3-10 parts of safflower, 8-20 parts of dipsaccharum, 10-30 parts of crab, 5-15 parts of drynaria, 5-15 parts of raw cyperus, 5-15 parts of Sappan wood, 5-15 parts of Corydalis, 8-20 parts of borneol, 10-20 parts of raw angelica, and 5-15 parts of zedoaria.

2. Use of a Chinese medicine composition for treating mid-term fracture according to claim 1 in the preparation of a medicine for treating mid-term fracture, characterized in that: The medicine further comprises a medically acceptable adjuvant, and the medicine is an oral preparation or an external preparation.

3. The use according to claim 2, characterized in that: The external preparation is a plaster or a spray.

4. The use according to claim 2, characterized in that: The oral preparation can be a decoction, a mixture, a decoction, a wine, a tincture, a powder, a honey pill, a granule, a capsule or a tablet.

5. Use of the Chinese medicine composition for treating mid-stage fracture according to claim 1 in the preparation of a medicine for treating fracture.

6. The use according to claim 5, characterized in that: The medicine for treating fractures is composed of the first Chinese medicine composition, the Chinese medicine composition for treating fractures in the middle stage according to claim 1, the second Chinese medicine composition, the third Chinese medicine composition, and the fourth Chinese medicine composition; in: The first Chinese medicine composition is composed of the following raw materials in parts by weight: 8-20 parts of Phellodendron amurense, 5-15 parts of Eupolyphaga sinensis, 8-20 parts of Phellodendron chinense, 8-20 parts of Rhubarb, 8-20 parts of Coptis chinensis, 8-20 parts of Scutellaria baicalensis, 8-20 parts of Dipsacus asper, 5-15 parts of Corydalis yanhusuo, 5-15 parts of Lycopodiella cuneata, 5-15 parts of Drynaria fortunei, 5-15 parts of Myrrha, 5-15 parts of Frankincense, 3-10 parts of Zedoariae rhizome, 3-10 parts of Sappan wood, and 3-10 parts of Borneolum; The second Chinese medicine composition is composed of the following raw materials in parts by weight: 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of erhusuo, 8-20 parts of angelica (washed with wine), 3-10 parts of dodder seeds (processed with salt), 3-10 parts of oxalis, 3-10 parts of zelan, 8-20 parts of sappan wood, 5-15 parts of millettia reticulata, 5-15 parts of mistletoe (steamed), 8-20 parts of borneol, 10-20 parts of raw angelica, 10-20 parts of raw cyperus; The third Chinese medicine composition is composed of the following raw materials in parts by weight: 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of notoginseng, 3-10 parts of eriocarpus (processed), 8-20 parts of salvia miltiorrhiza, 8-20 parts of angelica (washed with wine), 3-10 parts of oxalis, 3-10 parts of centipede, 3-10 parts of ligusticum chuanxiong, 8-20 parts of sappan wood, 3-10 parts of corydalis, 8-20 parts of borneol, 8-20 parts of raw cyperus, 10-20 parts of raw angelica; The fourth Chinese medicine composition is composed of the following raw materials in parts by weight: 8-20 parts of natural copper, 5-15 parts of earthworm, 8-20 parts of frankincense, 8-20 parts of myrrh, 5-15 parts of dragon's blood, 8-20 parts of Panax notoginseng, 3-10 parts of eriocarpus (processed), 3-10 parts of artificial musk, 3-10 parts of safflower, 3-10 parts of menthol, 8-20 parts of angelica, 8-20 parts of Corydalis, 8-20 parts of Sappan wood, 8-20 parts of borneol, and 3-10 parts of raw Cyperus rotundus.

7. A medicine for treating fractures according to claim 6, characterized in that: The second Chinese medicine composition is an oral dosage form.

8. A medicine for treating fractures according to claim 7, characterized in that: The first and third Chinese medicine compositions are external preparations, and the fourth Chinese medicine composition is an alcoholic preparation.

9. A medicine for treating fractures according to claim 8, characterized in that: The fourth Chinese medicine composition is used to prepare the first Chinese medicine composition.