Traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia

Abstract

The invention discloses a traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 9 to 15 parts of spica prunellae, 6 to 12 parts of herba artemisiae annuae, 3 to 9 parts of radix notoginseng, 6 to 10 parts of radix rubiae, 0.03 to 0.06 part of cantharides, 3 to 5 parts of myrrh, 3 to 10 parts of radix curcumae, 9 to 15 parts of radix isatidis, 10 to 15 parts of radix salviae miltiorrhizae, 2 to 5 parts of rhizoma coptidis, 3 to 9 parts of rhizoma paridis, 9 to 15 parts of semen plantaginis, 1.5 to 3 parts of lycoris radiate, 4.5 to 9 parts of calyx seu fructus physalis, 3 to 9 parts of cordyceps sinensis, 9 to 15 parts of radix adenophorae, 6 to 12 parts of radix ophiopogonis and 6 to 12 parts of herba dendrobii. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of radix polygonati officinalis, 6-12 parts of glossy privet fruit, 5-10 parts of liquorice, 15-25 parts of houttuynia cordata, 6-15 parts of alocasia macrorrhiza, 15-30 parts of aleppo avens, 15-30 parts of astragalus membranaceus, 0.1-0.3 part of croton, 1-3 parts of fructus piperis longi, 1-3 parts of cubeb and 5-12 parts of radix achyranthis bidentatae. The invention aims to provide the traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia, which is scientific in compatibility and good in treatment effect. The medicine is used for treating hyperlipidemia.

Description

Technical Field

[0001] The present invention relates to a Chinese medicine composition, and more specifically, to a Chinese medicine composition for treating three highs. The present invention also relates to a preparation method of the decoction of the Chinese medicine composition. Background Art

[0002] The three highs are a general term for high blood lipids, high blood pressure, and high blood sugar.

[0003] Hypertension refers to blood pressure in the circulatory system that is higher than normal, usually referring to increased blood pressure in the systemic arteries. It is a common clinical syndrome. Normal blood pressure is usually below 140 / 90 mmHg, while blood pressure is greater than or equal to 140 / 90 mmHg. Because it occurs unconsciously, it is called a "silent killer."

[0004] Hyperlipidemia refers to high cholesterol or triglycerides or low high-density lipoprotein cholesterol in the blood, which is called dyslipidemia in modern medicine. It is the main factor leading to atherosclerosis and a risk factor for the development of cardiovascular and cerebrovascular diseases. It is insidious and most of the time there are no clinical symptoms, so it is called the "invisible killer."

[0005] Hyperglycemia is a condition in which the glucose content in the blood is higher than normal. It is an independent pathological change in the body. The lesion is in the blood and the nature of the lesion is a disorder of blood sugar metabolism. The clinical manifestations of hyperglycemia can have obvious symptoms, such as dry mouth, frequent drinking, frequent urination, and weight loss; or they can be latent symptoms without obvious subjective discomfort.

[0006] The study showed that the clustering of these three clinical diseases is not accidental.

[0007] The mutual influence of high blood lipids and high blood pressure

[0008] What are the factors that affect high blood pressure? The endothelium of normal blood vessels is smooth and flowing, just like the elasticity of arterial walls, the peripheral resistance of blood vessels, and blood viscosity are important factors in the formation of hypertension. Increased blood lipids will gradually deposit under the endothelium of blood vessels as yellow atherosclerotic plaques. If not treated, they will gradually rupture, bleed, narrow blood vessels, and reduce blood fluidity, which will increase blood lipids and blood pressure. In fact, these three factors are also directly related to hyperlipidemia. Long-term accumulation of blood lipids can cause vascular sclerosis, weaken the elasticity of blood vessel walls, and increase blood pressure. This is the mutual influence of high blood lipids and high blood pressure, not only bad effects, because hyperlipidemia can also reduce the sensitivity of antihypertensive drugs when suffering from high blood lipids and high blood pressure at the same time. Therefore, the treatment of high blood pressure and high blood lipids should not only be unilaterally treated, but should be coordinated.

[0009] The mutual influence of high blood lipids and high blood sugar

[0010] Many diabetics have hyperlipidemia and believe that hyperlipidemia is a complication of diabetes. Moreover, those with elevated blood lipids are prone to cardiovascular and cerebrovascular complications. More than half of diabetic patients have lipid metabolism disorders. If you don’t check, you won’t know that diabetes causes elevated blood lipids mainly because when insulin is insufficient, the activity of lipase in the body will decrease, so blood lipids are prone to increase. On the other hand, diabetes is also accompanied by disorders of protein, water, fat, and electrolytes. On the other hand, if diabetics do less exercise but eat too much, the synthesis of lipids in the body will increase, leading to elevated blood lipids. What is the mutual influence between high blood lipids and high blood sugar? Just like when insulin changes unfavorably, patients with high blood lipids are prone to diabetes.

[0011] The mutual influence of hypertension and diabetes

[0012] In particular, obese hypertensive patients are often accompanied by diabetes, and vice versa, so many experts and scholars call the two homologous diseases. The main reasons are: they may have common genetic genes; diabetes can easily cause kidney damage, thereby increasing blood pressure. In addition, diabetics have increased blood sugar, which indirectly causes high blood pressure. It can be seen that the relationship between the three is close, so patients with hypertension and diabetes should have a deep understanding of lowering blood lipids.

[0013] At present, Western medicine treats the three highs based on specific diseases, which not only requires long-term medication and is prone to side effects, but also ignores the relationship between the three highs, which can easily lead to repeated changes in the condition and the need to constantly change or even increase the dosage of the medicine. Traditional Chinese medicine advocates dialectical treatment, but there is currently no more effective Chinese medicine combination or preparation that can solve the three highs problem. Summary of the invention

[0014] The purpose of the present invention is to provide a Chinese medicine composition for treating the three highs with scientific compatibility and good therapeutic effect in view of the deficiencies of the above-mentioned prior art.

[0015] The technical scheme of the present invention is achieved as follows: a traditional Chinese medicine composition for treating three highs, the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 9-15 parts of Prunella Vulgaris, 6-12 parts of Artemisia annua, 3-9 parts of Panax notoginseng, 6-10 parts of Rubia cordifolia, 0.03-0.06 parts of Myrrh, 3-5 parts of Curcuma, 9-15 parts of Isatis indigotica, 10-15 parts of Salvia miltiorrhiza, 2-5 parts of Coptis chinensis, 3-9 parts of Paris polyphylla, 1.5-3 parts of Lycoris radiata, 3-9 parts of Cordyceps sinensis, 9-15 parts of Adenophora australis, 6-12 parts of Ophiopogon japonicus, 6-12 parts of Dendrobium officinale, 6-12 parts of Polygonatum odoratum, 6-12 parts of Ligustrum lucidum, 5-10 parts of Licorice, 15-25 parts of Houttuynia cordata, 6-15 parts of Calla Lily, 15-30 parts of Indigofera chinensis, 15-30 parts of Astragalus, 0.1-0.3 parts of Croton tiglium, 1-3 parts of Piper longum and 1-3 parts of Solanum gracile, and 5-12 parts of Oxacina chinensis.

[0016] The above-mentioned traditional Chinese medicine composition for treating the three highs is composed of the following raw materials in parts by weight: 12 parts of Prunella Vulgaris, 10 parts of Artemisia annua, 6 parts of Panax notoginseng, 8 parts of Rubia cordifolia, 0.05 parts of Myrrh, 4 parts of Curcuma, 12 parts of Isatis root, 12 parts of Salvia miltiorrhiza, 3 parts of Coptidis rhizome, 6 parts of Paris polyphylla, 2.5 parts of Lycoris radix, 6 parts of Cordyceps sinensis, 12 parts of Adenophora australis, 9 parts of Ophiopogon japonicus, 9 parts of Dendrobium candidum, 9 parts of Polygonatum odoratum, 9 parts of Ligustrum lucidum, 8 parts of Licorice, 20 parts of Houttuynia cordata, 10 parts of Calla lily, 20 parts of Indigofera indigofera, 22 parts of Astragalus, 0.2 parts of Croton, 2 parts of Piper longum, 2 parts of Solanum gracile, and 8 parts of Oxyphylla.

[0017] According to TCM theory, the three highs are a chronic disease caused by the deficiency of both yin and yang. The formula of the present invention firstly solves the problem of "overdosage" of Radix Isatidis, Houttuynia and Licorice through the blood-activating and blood-stasis-removing effects of madder, myrrh, salvia miltiorrhiza, turmeric and lacquer. At the same time, the toxicity of a small amount of croton, calla lily and mylabris is solved through the original stewing process, and the blood-activating and blood-stasis-removing effects solve most of the toxicity problems.

[0018] Furthermore, use Prunella vulgaris and Artemisia annua to eliminate deficiency and excess heat syndrome; use the function of Astragalus membranaceus to regulate sugar metabolism to lower blood sugar, use Rubia cordifolia, Myrrha, Salvia miltiorrhiza, Curcuma aromatica and Oxacina chinensis to cooperate with each other to achieve blood stasis and solve the problem of high blood pressure; use the method of replenishing Yin, through the combination of Adenophora australis, Ophiopogon japonicus, Dendrobium officinale, Polygonatum odoratum and Ligustrum lucidum to solve the problem of high blood lipids. At the same time, the cause of the three highs is insufficient Yang, and Cordyceps sinensis, Croton, Piper longum and Solanum membranaceus are used to replenish Yang and strengthen Yang. Then use Astragalus membranaceus to replenish Qi, so that the effect is better.

[0019] Furthermore, the combination of Chinese lantern and plantain seeds with liquorice and isatis root has better heat-clearing and detoxifying effects. Experiments have shown that after adding the above two herbs, it has a better effect on patients with body heat. In addition, for those with more severe symptoms and severe yang deficiency, adding croton, longan and bichengqi can effectively replenish yang and detoxify.

[0020] According to practice, after taking the formula of the present invention for about one year, blood pressure can be reduced from 100-120 / 170-190 mmHg to 65-75 / 110-125 mmHg, blood sugar can be reduced from 11.2-17.8 mmol / L after meal to 5.1-7.3 mmol / L, and total cholesterol in blood lipids can be reduced from the original 8-9.5 mmol / L to 3.6-4.5 mmol / L, with significant effects. DETAILED DESCRIPTION

[0021] The present invention will be further described in detail below in conjunction with specific embodiments, but they do not constitute any limitation to the present invention.

[0022] The invention discloses a traditional Chinese medicine composition for treating three highs. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 9-15 parts of Prunella Vulgaris, 6-12 parts of Artemisia annua, 3-9 parts of Panax notoginseng, 6-10 parts of Rubia cordifolia, 0.03-0.06 parts of Myrrha, 3-5 parts of Curcuma, 9-15 parts of Isatis indigotica, 10-15 parts of Salvia miltiorrhiza, 2-5 parts of Coptis chinensis, 3-9 parts of Paris polyphylla, and Stone 1.5-3 parts of garlic, 3-9 parts of cordyceps sinensis, 9-15 parts of Adenophora australis, 6-12 parts of Ophiopogon japonicus, 6-12 parts of Dendrobium officinale, 6-12 parts of Polygonatum odoratum, 6-12 parts of Ligustrum lucidum, 5-10 parts of Licorice, 15-25 parts of Houttuynia cordata, 6-15 parts of Alocasia salsa, 15-30 parts of Blue Bu Zheng, 0.1-0.3 parts of Croton, 1-3 parts of Piper longum and 1-3 parts of Solanum melongena, 5-12 parts of Ox lacquer. This prescription is suitable for patients with more severe symptoms and severe yang deficiency.

[0023] Further preferably, the Chinese medicine composition is composed of the following raw materials in parts by weight: 12 parts of Prunella Vulgaris, 10 parts of Artemisia annua, 6 parts of Panax notoginseng, 8 parts of Rubia cordifolia, 0.05 parts of Myrrh, 4 parts of Curcuma, 6 parts of Isatis root, 12 parts of Salvia miltiorrhiza, 3 parts of Coptidis rhizome, 6 parts of Paris polyphylla, 2.5 parts of Lycoris radix, 6 parts of Cordyceps sinensis, 12 parts of Adenophora australis, 9 parts of Ophiopogon japonicus, 9 parts of Dendrobium candidum, 9 parts of Polygonatum odoratum, 9 parts of Ligustrum lucidum, 8 parts of Licorice, 20 parts of Houttuynia cordata, 10 parts of Calla lily, 20 parts of Indigofera tinctorius, 0.2 parts of Croton tiglium, 2 parts of Piper longum, 2 parts of Solanum melongena, and 8 parts of Oxyphylla.

[0024] The present invention provides a method for preparing the above-mentioned Chinese medicine composition decoction, comprising the following steps:

[0025] (1) Weigh each raw material according to the formula and set aside;

[0026] (2) Pre-detoxification of the blister beetle, calla lily and croton; the pre-detoxification treatment is specifically as follows: (a) placing the blister beetle, calla lily and croton in containers respectively, adding liquor with a concentration of more than 50 degrees and alkaloids, wherein the amount of liquor added is such that the raw materials are covered by 1-2 cm; the amount of alkaloids added is 10%-20% of the dry weight of the raw materials in the container; (b) heating the container to 60°C-80°C, keeping the temperature and letting it stand for 1 week; (c) repeatedly washing the raw materials after standing with clean water for 2-3 times and then drying them.

[0027] (3) The detoxified blister beetles, calla lilies and croton seeds are boiled together with other raw materials to prepare a decoction.

[0028] Example 1

[0029] Formula: 9 parts of Prunella Vulgaris, 6-12 parts of Artemisia annua, 3-9 parts of Panax notoginseng, 6-10 parts of Rubia cordifolia, 0.03-0.06 parts of Myrrh, 3-5 parts of Myrrh, 3-10 parts of Curcuma, 9 parts of Isatis root, 10 parts of Salvia miltiorrhiza, 2 parts of Coptidis rhizome, 3 parts of Paris polyphylla, 9 parts of Plantago, 1.5 parts of Lycoris radix, 4.5 parts of Lantern Festival, 3 parts of Cordyceps sinensis, 9 parts of Adenophora australis, 6 parts of Ophiopogon japonicus, 6 parts of Dendrobium officinale, 6 parts of Polygonatum odoratum, 6 parts of Ligustrum lucidum, 5 parts of Licorice, 15-25 parts of Houttuynia cordata, 6 parts of Calla lily, 15 parts of Indigofera indigofera, 15 parts of Astragalus, 0.1 part of Croton, 1 part of Piper longum and 1 part of Solanum melongena, and 6 parts of Ox lacquer.

[0030] Preparation process:

[0031] (1) Weigh each raw material according to the formula and set aside;

[0032] (2) Pre-detoxification of the blister beetle, calla lily and croton; the pre-detoxification treatment is specifically as follows: (a) placing the blister beetle, calla lily and croton in containers respectively, adding liquor with a concentration of more than 50 degrees and alkaloids, wherein the amount of liquor added is such that the raw materials are covered by 1-2 cm; the amount of alkaloids added is 10%-20% of the dry weight of the raw materials in the container; (b) heating the container to 60°C-80°C, keeping the temperature and letting it stand for 1 week; (c) repeatedly washing the raw materials after standing with clean water for 2-3 times and then drying them.

[0033] (3) The detoxified blister beetles, calla lilies and croton seeds are boiled together with other raw materials to prepare a decoction.

[0034] Example 2

[0035] Formula: 12 parts of Prunella Vulgaris, 10 parts of Artemisia annua, 6 parts of Panax notoginseng, 8 parts of Rubia cordifolia, 0.05 parts of Myrrh, 4 parts of Curcuma, 6 parts of Isatis Radix, 12 parts of Salvia miltiorrhiza, 3 parts of Coptidis, 6 parts of Paris polyphylla, 12 parts of Plantago, 2 parts of Lycoris radix, 6 parts of Lantern Festival, 6 parts of Cordyceps sinensis, 12 parts of Adenophora australis, 9 parts of Ophiopogon japonicus, 9 parts of Dendrobium officinale, 9 parts of Polygonatum odoratum, 9 parts of Ligustrum lucidum, 8 parts of Licorice, 20 parts of Houttuynia cordata, 10 parts of Calla Lily, 20 parts of Indigofera indigofera, 22 parts of Astragalus, 0.2 parts of Croton, 2 parts of Piper longum, 2 parts of Solanum melongena, and 8 parts of Ox lacquer.

[0036] The decoction preparation process is the same as that in Example 1.

[0037] Example 3

[0038] Formula: 15 parts of Prunella Vulgaris, 12 parts of Artemisia annua, 9 parts of Panax notoginseng, 10 parts of Rubia cordifolia, 0.06 parts of Myrrh, 5 parts of Curcuma, 15 parts of Isatis root, 15 parts of Salvia miltiorrhiza, 5 parts of Coptidis, 9 parts of Paris polyphylla, 15 parts of Plantago seed, 3 parts of Lycoris radix, 9 parts of Lantern Festival, 9 parts of Cordyceps sinensis, 15 parts of Adenophora australis, 12 parts of Ophiopogon japonicus, 12 parts of Dendrobium officinale, 12 parts of Polygonatum odoratum, 12 parts of Ligustrum lucidum, 10 parts of Licorice, 25 parts of Houttuynia cordata, 15 parts of Calla Lily, 30 parts of Indigofera chinensis, 30 parts of Astragalus, 0.3 parts of Croton, 3 parts of Piper longum and 3 parts of Solanum melongena, and 12 parts of Ox lacquer.

[0039] The decoction preparation process is the same as that in Example 1.

[0040] Clinical effect examples:

[0041] From October 2019 to October 2024, 64 patients with different symptoms of the three highs were treated with the Chinese medicine composition decoction provided by the present invention, and the treatment effect was tracked and statistically analyzed. Among them, there were 46 male patients and 18 female patients with an average age of 45 years old. The treatment lasted for 30-90 days, and 58 patients were cured, with a cure rate of 90.6%. The conditions of the remaining patients were significantly improved, and there were no patients with ineffective treatment. The following are some typical cases:

[0042] Patient 1, female, 62 years old, suffered from hypertension and hyperglycemia for many years, and often felt weakness in the limbs, chest tightness, and dizziness; after examination, her blood pressure was 112 / 173 mmHg, and her postprandial blood sugar was 11.36 mmol / L. After continuous use of the Chinese medicine composition decoction provided by the present invention for 3 months, all indicators returned to normal and there has been no recurrence so far.

[0043] Patient 2, male, 55 years old, obese, suffered from three high symptoms, often felt weak legs and feet, accompanied by insomnia; after examination, his blood pressure was 112 / 176mmHg, glycerate was 6.21mmol / L, and blood sugar was 12.95mmol / L one hour after meal. After continuous use of the Chinese medicine composition decoction provided by the present invention for 60 days of continuous treatment, all indicators returned to normal and no recurrence has occurred so far.

[0044] Patient 3, male, 45 years old, overweight, suffered from hypertension and hyperlipidemia, often felt dizzy, chest tightness, sore waist and knees; after examination, his blood pressure was 102 / 178mmHg, glycerate was 4.68mmol / L, and total cholesterol was 9.12mmol / L. After continuous use of the Chinese medicine composition decoction provided by the present invention for 30 days of continuous treatment, all indicators returned to normal and no recurrence has occurred so far.

[0045] Patient 4, female, 56 years old, obese, hypertension, hyperglycemia, headache and dizziness for 2 years, accompanied by fatigue, memory loss, bone steaming and fever symptoms, blood pressure 113 / 186mmHg, total cholesterol 6.83mmol / L, triglyceride 3.25mm / L, fasting blood sugar 7.65mmol / L, blood sugar 11.9mmol / L 2 hours after meal, Western medicine diagnosis of hypertension, hyperlipidemia, hyperglycemia. Taking a variety of Western medicines is not effective, after taking the Chinese medicine composition decoction of the present invention for 30 days, the symptoms are significantly improved, and recovery has been achieved after continuous taking for 3 months, and there has been no recurrence so far.

[0046] Patient 5, male, 72 years old, suffered from hypertension and hyperglycemia, and also had symptoms such as kidney yin deficiency, soreness of muscles and bones, and cramps, with blood pressure of 100 / 180 mmHg, fasting blood sugar of 7.1 mm / L, and blood sugar of 11.8 mm / L 2 hours after meal. He recovered after taking the decoction of the Chinese medicine composition of the present invention for 3 months and has not relapsed so far.

[0047] Patient 6, male, 47 years old, obese, suffered from hypertension, hyperlipidemia, hyperglycemia, and went to the provincial capital hospital for treatment many times. His blood pressure still remained at a high level. He often suffered from leg numbness, dizziness, dry mouth and thirst, and leg cramps at night. After taking the decoction of the Chinese medicine composition of the present invention for 2 months, his blood pressure stabilized, his blood sugar decreased, and the pain in his legs was significantly relieved. He recovered after taking the decoction of the Chinese medicine composition of the present invention for 3 months and has not relapsed so far.

[0048] The above embodiments are preferred implementation modes of the present invention and are only used to facilitate the description of the present invention. They are not intended to limit the present invention in any form. Any person with ordinary knowledge in the relevant technical field, if they do not depart from the scope of the technical features of the present invention, can make equivalent embodiments by partial changes or modifications to the technical contents disclosed in the present invention, and they still fall within the scope of the technical features of the present invention without departing from the technical features of the present invention.

Claims

1. A Chinese medicine composition for treating three highs, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 9-15 parts of Prunella Vulgaris, 6-12 parts of Artemisia annua, 3-9 parts of Panax notoginseng, 6-10 parts of Rubia cordifolia, 0.03-0.06 parts of Myrrha, 3-5 parts of Curcuma, 9-15 parts of Isatis indigotica, 10-15 parts of Salvia miltiorrhiza, 2-5 parts of Coptis chinensis, 3-9 parts of Paris polyphylla, 9-15 parts of Plantago, 1.5-3 parts of Lycoris radix and 4.5 parts of Lantern Festival. -9 parts, Cordyceps sinensis 3-9 parts, Adenophora australis 9-15 parts, Ophiopogon japonicus 6-12 parts, Dendrobium candidum 6-12 parts, Polygonatum odoratum 6-12 parts, Ligustrum lucidum 6-12 parts, Licorice root 5-10 parts, Houttuynia cordata 15-25 parts, Alocasia salsa 6-15 parts, Indigofera indigofera 15-30 parts, Astragalus membranaceus 15-30 parts, Croton 0.1-0.3 parts, Piper longum 1-3 parts and Solanum gracile 1-3 parts, Ox lacquer 5-12 parts.

2. A Chinese medicine composition for treating three highs according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 12 parts of Prunella Vulgaris, 10 parts of Artemisia annua, 6 parts of Panax notoginseng, 8 parts of Rubia cordifolia, 0.05 parts of Myrrha, 4 parts of Curcuma, 6 parts of Isatis indigotica, 12 parts of Salvia miltiorrhiza, 3 parts of Coptis chinensis, 6 parts of Paris polyphylla, 2.5 parts of Lycoris radix, 6 parts of Cordyceps sinensis, 12 parts of Adenophora australis, 9 parts of Ophiopogon japonicus, 9 parts of Dendrobium candidum, 9 parts of Polygonatum odoratum, 9 parts of Ligustrum lucidum, 8 parts of Liquorice, 20 parts of Houttuynia cordata, 10 parts of Alocasia salviae, 20 parts of Indigofera chinensis, 22 parts of Astragalus, 0.2 parts of Croton, 2 parts of Piper longum, 2 parts of Solanum lycopersicum and 8 parts of Oxyphylla lacryma-jobi.