Liquid delivery cap with alignment confirmation

Abstract

A cover device (100) for a liquid delivery device (200) operates to detect a position of the liquid delivery device relative to the cover device when the liquid delivery device is inserted into and rotated relative to the cover device. The cover device includes one or more sensors (120) configured to detect a position of the liquid delivery device relative to the cover device. The position of the liquid delivery device can be used to determine whether the liquid delivery device is inserted and arranged in an appropriate axial and / or radial position relative to the cover device, so that the cover device can accurately detect the state of the liquid delivery device.

Description

[0001] This application is a divisional application of a patent application with an application date of June 19, 2020, application number 202080056655.4, and invention name “Liquid delivery cover with alignment confirmation”. Field of the Invention

[0002] Described herein are devices, systems, and methods related to a cap device for a fluid delivery device, for example, the cap device being configured to detect a plunger of the fluid delivery device. Background Art

[0003] Liquid delivery systems are often used to deliver a measured amount of medication to a patient. For example, pen-type syringe delivery devices have been used to deliver measured amounts of medication and include a delivery end that is capped for storage between uses, and a plunger that is movable within a reservoir and can dispense a measured dose. The cap device can protect the delivery end from damage during storage and can be used to display information to the user, such as the duration since the cap was last removed during a previous use of the injection device or information about the contents of the delivery device. Summary of the invention

[0004] Some embodiments described herein include a cover device, a system and a method, which are configured to detect the position (e.g., radial orientation or axial position) of a liquid delivery device relative to a cover device, the state of the liquid delivery device, and / or output dosage information based at least in part on the detected state. For example, a liquid delivery system may include a liquid delivery device having a reservoir and a removable plunger that causes liquid to flow out of the reservoir, and a cover device configured to cover at least the delivery end of the liquid delivery device. The cover device includes one or more sensors configured to detect the position of the liquid delivery device relative to the cover device, and / or detect the state of the liquid delivery device. For example, the position of the liquid delivery device can be used to determine whether the liquid delivery device is inserted, and is arranged in a suitable axial and / or radial position relative to the cover device, so that the cover device can accurately detect the state of the liquid delivery device. Alternatively or additionally, the detected position information can be used during the subsequent determination of the state of the liquid delivery device. The state of the liquid delivery device may include the position of the plunger, which can be used to determine the liquid volume in the reservoir, dosage information (e.g., the previously delivered dosage volume), and / or other information related to the liquid delivery device and its operation. In an exemplary embodiment, detecting proper axial and / or radial alignment facilitates detecting accurate and reliable fluid volume and dosage information.

[0005] In some instances, the cover device is configured to receive at least a portion of the liquid conveying device axially in the cover device so that the liquid conveying device can be rotated at least partially relative to the cover device. In certain embodiments, the cover device is configured to receive the liquid conveying device axially on a plurality of possible orientations, and feedback is provided, such as machinery (for example, click sound sense / sense of snapping into), visible and / or audible feedback, to indicate that the liquid conveying device is inserted into a predetermined axial position. Alternatively or additionally, the cover device is configured to detect whether the liquid conveying device is axially inserted in the cover device (for example, engaged with the cover device) and / or detects the axial alignment position of the liquid conveying device relative to the cover device. In addition, in some embodiments, the cover device can be configured to detect the radial position of the liquid conveying device, and determine whether the liquid conveying device is rotated to a predetermined radial position (for example, radial alignment position) relative to the cover device (for example, when the user rotates the liquid conveying device relative to the cover device). For example, the cover device monitors the change of the sensor signal generated by one or more sensors, and detects the predetermined feature of the liquid conveying device based on the change of the sensor signal when the liquid conveying device has been rotated to a predetermined orientation. In addition, the cover device can be configured to provide feedback, such as mechanical (for example, click sound sense / snap-in sense), visible and / or audible feedback, to ensure that the liquid transport device rotates to a predetermined radial position and / or the liquid transport device does not rotate beyond the predetermined radial position. The radial alignment position can be a single radial position or a plurality of radial positions, and each radial position provides suitable sight line for accurate plunger detection. Similarly, the axial alignment position can comprise one or more axial positions that allow the liquid transport device to rotate to the radial alignment position, and / or one or more axial positions that the liquid transport device engages with the cover device.

[0006] Some exemplary cover devices may include one or more mechanical feedback structures, such as user-perceptible snaps, snaps, and other mechanical interactions, which generate physical feedback (e.g., a click) when the liquid delivery device is engaged with the cover device in an axial direction and / or when the liquid delivery device is in a predetermined radial position.

[0007] Some exemplary cover devices can provide one or more outputs related to the relative position of the cover device and the liquid transporting device.For example, the cover device includes one or more output devices, and the output device outputs the information indicating the axial position and / or radial position of the liquid transporting device relative to the cover device. In addition, the cover device can present information to prompt and / or assist the user to insert the liquid transporting device into the cover device and align. The information can be presented in various forms, such as visual, audible and / or tactile forms. In certain embodiments, the output device includes a display device configured to display symbols (for example, marks, text, letters, numbers, colors, animations, etc.), and these symbols indicate the position of the liquid transporting device relative to the main body, for example, whether the liquid transporting device is in the axial alignment position and / or the radial alignment position. Such symbol display can be used to promote the user to correctly insert the liquid transporting device and be arranged in the cover device, so as to accurately and reliably measure.

[0008] In some embodiments, the cover device optionally includes a body and a sensor bracket movably located in the body. At least one of the sensors configured to detect the radial position of the liquid delivery device relative to the cover device can be mounted on the sensor bracket. Alternatively or additionally, one or more of the sensors can be fixedly positioned relative to the body of the cover device, and the sensor is configured to detect the radial position of the liquid delivery device relative to the cover device.

[0009] The sensor can be operated to output a sensor signal. The sensor signal can vary based on the characteristics of the liquid delivery device encountered by one or more sensors. For example, the sensor signal can be different depending on the axial and / or radial positioning of the liquid delivery device relative to the cover device. In addition, the sensor signal can vary based on the plunger or liquid in the reservoir, transparent or opaque features, numbers / letters, scale markings, etc. In certain embodiments, the sensor bracket can be moved between the first and second positions without user operation, or can be moved by positioning the cover device on the liquid delivery device without additional user operation.

[0010] Some exemplary cover devices can contribute to the arrangement of the liquid transporting device relative to the cover device in the axial and / or radial position, thereby allowing to accurately and repeatably detect the plunger position of the liquid transporting device. For example, the plunger position can be used to determine the volume of the previous delivery dose or the volume remaining in the reservoir. Alternatively or in addition, some embodiments promote accurate and repeatable measurement by reducing the manual manipulation during the detection. For example, when the liquid transporting device is at least partially received in the cover device, the sensor bracket can be moved between the first and second positions, and except for the operation of engaging the liquid transporting device with the cover device, there is no need for the user to perform additional manual operation.

[0011] Some exemplary cap devices can determine that liquid conveying device is not aligned radially with cap device at the first time, and then determine that liquid conveying device is aligned radially with cap device at the second time later.Radial alignment allows cap device to obtain accurate measurement of liquid conveying device state (for example, plunger position, the amount of liquid remaining in liquid conveying device, etc.) at the second time, and radial misalignment may cause inaccurate measurement of liquid conveying device state.For example, after cap device is inserted axially on liquid conveying device, user may ignore cap device and liquid conveying device being placed in predetermined radial alignment.If cap device and liquid conveying device are not in predetermined radial alignment before user subsequently removes cap device from liquid conveying device (for example, for subsequent liquid injection), then at a later time, cap device is replaced on liquid conveying device with predetermined radial alignment subsequently, then cap can determine the approximate state of liquid conveying device (for example, plunger position, the amount of liquid remaining in liquid conveying device, etc.) at the time before and after. The cap device may determine the approximate state of the fluid delivery device at a previous time (when the cap device was in radial misalignment) based on, for example, the user's glycemic response, the user's historical dosage, the user's treatment parameters, or any other information that may approximate the condition.

[0012] The specific embodiment described herein includes a cover device for a liquid delivery device. The cover device may include a main body and a first sensor. The main body defines a cavity configured to at least partially receive the liquid delivery device. When the liquid delivery device is at least partially received in the cavity of the main body, the first sensor is configured to output a sensor signal indicating the radial alignment position of the liquid delivery device relative to the main body.

[0013] In some embodiments, the cover device can optionally include one or more of the following features.

[0014] The cap device may include a second sensor configured to output a sensor signal indicating a plunger of the liquid delivery device; and a processor configured to: determine that the liquid delivery device is not in a radially aligned position at a first time; determine that the liquid delivery device is in a radially aligned position at a second time later than the first time; determine the position of the plunger at the second time using the second sensor; and calculate the approximate position of the plunger at the first time based at least in part on the position of the plunger at the second time. The approximate position of the plunger at the first time may also be based on at least one of the user's glycemic response, the user's historical dose, and the user's treatment parameters.

[0015] The cap device may include a processor configured to detect a radial alignment position of the liquid delivery device based on the sensor signal of the first sensor.

[0016] The first sensor may be configured to output a sensor signal indicative of the radial alignment position when the first sensor is located at a predetermined axial position along the fluid delivery device.

[0017] The cover device may include a sensor bracket, and the sensor bracket is movable between a first position and a second position within the cavity when the liquid delivery device is in a fixed position relative to the cavity. The first sensor may be located on the sensor bracket. Alternatively, the first sensor may be fixedly mounted to the body.

[0018] The cap device may include a second sensor. The second sensor may be located on the sensor bracket. When the sensor bracket moves between the first position and the second position, the second sensor may be configured to output a sensor signal indicative of the plunger of the liquid delivery device.

[0019] The cover device may include a motor configured to move the sensor bracket between the first position and the second position.

[0020] The processor may be configured to determine a status associated with the fluid delivery device based on the sensor signal of the first sensor and the sensor signal of the second sensor.

[0021] The processor can be configured to record a first time that the liquid delivery device is axially received in the cavity of the body, and a second time that the liquid delivery device is moved to the radially aligned position. The processor can determine a state associated with the liquid delivery device based on the sensor signal of the first sensor, the sensor signal of the second sensor, the first time, and the second time.

[0022] The first sensor may include a first light emitter and a first light receiver. An optical path may be defined between the first light emitter and the first light receiver. The first sensor may be operable to detect the physical characteristic by outputting a sensor signal indicative of the physical characteristic of the liquid delivery device.

[0023] The second sensor may include a second light emitter and a second light receiver. An optical path may be defined between the second light emitter and the second light receiver. The second sensor may be operable to detect the physical characteristic by outputting a sensor signal indicative of the physical characteristic of the liquid delivery device.

[0024] The cover device may include a position sensor configured to detect an axial position of the sensor bracket within the body. The physical feature of the liquid delivery device may include a plunger of the liquid delivery device. The processor is operable to detect the plunger of the liquid delivery device based on a change in the sensor signal, and determine a corresponding position of the plunger based on the sensor signal output by the position sensor.

[0025] The status associated with the liquid delivery device may include at least one of: the volume of a dose delivered by the liquid delivery device, the total volume of liquid remaining in the liquid delivery device, the number of doses remaining in the liquid delivery device, the duration remaining before the liquid delivery device is empty, and the time of the previous dose, the time elapsed since the last dose.

[0026] The cap means may comprise an axial position means configured to engage a liquid delivery means inserted axially into the cavity of the body. The axial position means may generate a first mechanical feedback when the liquid delivery means engages the axial position means.

[0027] The axial position device may include a sensor configured to generate a sensor signal indicative of engagement of the fluid delivery device with the axial position device.

[0028] The body of the cap device is configured to axially receive at least a portion of the fluid delivery device in the cavity. The fluid delivery device is at least partially rotatable relative to the body when at least a portion of the fluid delivery device is in the cavity.

[0029] The sensor bracket may mount the first sensor. The motor may be operable to move the sensor bracket to a predetermined axial position where the first sensor is arranged to detect a radially aligned position of the fluid delivery device.

[0030] The cap device may include a radial retention structure configured to generate a second mechanical feedback upon detecting a radially aligned position of the fluid delivery device.

[0031] The cap device may include a display device configured to output information indicative of the position of the fluid delivery device relative to the body.

[0032] The cap device may include a sleeve configured to receive at least a portion of the fluid delivery device. The sensor bracket may be configured to move along an outer side of the sleeve.

[0033] Certain embodiments described herein include a method for operating a cap device for a fluid delivery device. The method includes: detecting a radial position of the fluid delivery device relative to a body of the cap device when the fluid delivery device is at least partially within the cap device; and outputting information related to the radial position of the fluid delivery device.

[0034] In some embodiments, the method may optionally include one or more of the following features.

[0035] The method may include detecting engagement of the liquid delivery device with the cap device prior to detecting the radial position.The liquid delivery device may be rotatable relative to the body of the cap device.

[0036] The information may indicate whether the radial position of the fluid delivery device has been moved to a predetermined radial alignment position.

[0037] The method may also include: determining that the liquid delivery device is not radially aligned with the body of the cap device at a first time; determining that the liquid delivery device is radially aligned with the body of the cap device at a second time later than the first time; determining the position of the plunger at the second time; and calculating the approximate position of the plunger at the first time based at least in part on the position of the plunger at the second time. The approximate position of the plunger at the first time may also be based on at least one of the user's glycemic response, the user's historical dose, and the user's treatment parameters.

[0038] The method may include generating a first mechanical feedback when the fluid delivery device moves to a predetermined axial alignment position.

[0039] The method may include generating a second mechanical feedback when the radial position of the fluid delivery device moves to a predetermined radial alignment position.

[0040] The method may include activating the cap device when the fluid delivery device is moved to the predetermined axial alignment position.

[0041] The method may include detecting a first time that a fluid delivery device is axially engaged in a cavity of a body; detecting a second time that the fluid delivery device is in a predetermined radial alignment position; detecting a characteristic associated with the fluid delivery device using a sensor; and determining a state associated with the fluid delivery device based on the characteristic, the first time, and the second time.

[0042] Detecting the radial position of the fluid delivery device may include receiving a sensor signal from the first sensor indicative of a radially aligned position of the fluid delivery device relative to the body of the cap device.

[0043] The method may include driving a sensor carrier including a first sensor to a predetermined axial position within the cover device.When the sensor carrier is arranged in the predetermined axial position, the first sensor may be configured to generate a sensor signal indicative of the radial alignment position.

[0044] The method may include driving a sensor holder including a second sensor between a first position and a second position within the body of the cap device while detecting the radial position of the fluid delivery device. The method may also include detecting a physical characteristic of the fluid delivery device while the sensor holder moves between the first position and the second position.

[0045] Detecting the physical characteristic of the fluid delivery device may include receiving a sensor signal indicative of a plunger of the fluid delivery device from the second sensor when the sensor bracket moves between the first position and the second position.

[0046] Certain embodiments described herein include a cap device. The cap device may include a body and a sensor. The body may be configured to at least partially receive a liquid delivery device. The sensor may be configured to output a sensor signal indicating a radial position of the liquid delivery device relative to the body.

[0047] Certain embodiments described herein include a cap device. The cap device may include a member for at least partially receiving a fluid delivery device; and a member for detecting a radial position of the fluid delivery device.

[0048] The devices, systems and techniques described herein may provide one or more of the following advantages. First, some embodiments described herein include a cover device that may facilitate the placement of a liquid delivery device in a position relative to the cover device, thereby facilitating accurate, reliable and repeatable measurements associated with the liquid delivery device. For example, the cover device includes one or more sensors that detect the axial and / or radial position of the liquid delivery device relative to the cover device and determine whether the liquid delivery device is in a predetermined axial and / or radial alignment relative to the cover device to facilitate accurate, reliable and repeatable monitoring and determination of states associated with the liquid delivery device, such as the volume of liquid in a reservoir, dosage information (e.g., the volume of a previously delivered dose and the amount of drug remaining in the liquid delivery device), and / or other information related to the liquid delivery device and its operation.

[0049] Second, some embodiments described herein include a cover device that can help a user properly position the cover device on a liquid delivery device. For example, the cover device can generate feedback to the user to help the liquid delivery device axially and / or radially align with respect to the cover device. Such feedback may include outputting information indicating the current position of the liquid delivery system, and / or outputting information indicating that the liquid delivery system is arranged to be aligned with the cover device (for example, the cover device and the liquid delivery device rotate relative to each other) required for one or more actions. Feedback can be provided in different forms, such as audible feedback, tactile feedback or other visible or physical feedback. In various exemplary embodiments, the cover device can generate output based on one or more sensor signals. Alternatively or additionally, the output may include user-perceivable snap-ins, snap-ins, mechanical interactions, etc. indicating appropriate axial alignment, radial alignment, etc.

[0050] Third, some embodiments described herein include a cap device that can perform one or more tasks based on the radial alignment of the liquid transport device relative to the cap device. For example, the cap device can detect the plunger position or other state of the liquid transport device based at least in part on information related to the radial position of the liquid transport device. After the liquid transport device is in a predetermined radial alignment, the plunger position or other state of the liquid transport device can be detected. Alternatively or additionally, information about the radial alignment of the liquid transport device can be used to determine the state of the liquid transport device.

[0051] Fourth, some embodiments described herein may facilitate dose detection that is not simultaneous with dose delivery. For example, the cap device may be configured to detect the plunger position or other state of the liquid delivery device at the time when the liquid delivery device is in proper radial alignment relative to the cap device, which may occur some time after dosing and / or initial capping of the liquid delivery device. In other words, detection may occur independently of the timing of dosing.

[0052] Fifth, some embodiments described herein can track the state of the liquid delivery device over time, and update the dosage information related to the dosage delivered at the previous time when appropriate. For example, the cover device is operable to measure / calculate the dosage of the liquid from the liquid delivery device (for example, whether the liquid delivery device is in a specific predetermined alignment with the cover device, such as when the liquid delivery device is only axially inserted into the cover device and is not rotated to a predetermined radial position relative to the cover device). The cover device is operable to identify the time when the liquid delivery device moves to the predetermined alignment with the cover device, and also operates to measure / calculate the dosage of the liquid delivered from the liquid delivery device at the previous time. Such features can help track and output accurate information associated with the liquid delivery device over a period of time.

[0053] Sixth, some embodiments described herein include a sensor bracket that carries a sensor assembly (and / or a sensor assembly that can be moved with limited or no manual user operation) that can facilitate consistent travel speeds and / or accelerations, thereby facilitating consistent and predictable sensor signals. User influence on sensor bracket dynamics can be reduced, and manufacturing design tolerances that can cause the sensor bracket to play or otherwise move unexpectedly during sensor bracket operation can be reduced.

[0054] Seventh, some embodiments described herein can facilitate accurate and repeatable measurements associated with a liquid delivery device by using a combination of sensor types. In some embodiments, the cover device includes one or more optical sensors and position sensors, such as linear potentiometers, optical encoders, rotary encoders, magnetic potentiometers, membrane potentiometers, load cells, etc. Such a combination of sensor types helps to accurately assess the relative positions of various features of the liquid delivery device and / or the changes in the positions of various features during subsequent scans of the liquid delivery device.

[0055] Eighth, the cover device can facilitate an efficient and cost-effective manufacturing and assembly process by including relatively few sensors. In some embodiments, the cover device includes one or two liquid delivery device sensors (e.g., plunger sensors), such as one or two optical sensors; and position sensors, such as linear potentiometers, optical encoders, rotary encoders, magnetic potentiometers, membrane potentiometers, etc. Therefore, such a configuration includes relatively few sensors and reduces the number of assembly and / or calibration steps that may be applicable when multiple sensors are assembled into the cover device.

[0056] Ninth, various embodiments described herein may include a cap device compatible with various liquid delivery device types. For example, the cap device can facilitate accurate and repeatable measurements, even when used with different liquid delivery device types, the liquid delivery device types may have different shapes, sizes and features that interact differently with the sensors and other features of the cap device. One or more optical sensors of the sensor bracket may be oriented to obtain a predetermined line of sight that can facilitate reliable plunger detection of various different liquid delivery device types. For example, the optical sensor may be arranged so that at least one optical sensor is positioned to detect the plunger, even if another optical sensor is blocked by the features of the liquid delivery device in certain circumstances.

[0057] Tenth, some cap devices described herein improve the user experience of a liquid delivery system by automating some operations related to dose measurement and management. For example, the cap device may deliver an output that informs the user of the previously delivered liquid dose, the duration since the previous dose, the number of remaining doses, the volume of remaining liquid, and the expected remaining useful life of the liquid delivery device.

[0058] Eleventh, in some optional embodiments, the cover device described herein can improve the user experience of the liquid delivery system by facilitating semi-automatic or automated operation. For example, little or no manual operation may be required except for engaging the cover device with the liquid delivery device. In some optional embodiments including a movable sensor bracket, the sensor bracket can be placed in a first position by engaging the cover device to the liquid delivery device, and the sensor bracket can be automatically released so that the sensor bracket can be moved from the first position to the second position while operating to scan the liquid delivery device.

[0059] Twelfth, some embodiments described herein contribute to a durable cover device that can operate over an extended period of time and / or can be used with many liquid delivery devices. For example, a single cover device can be reused with many disposable liquid delivery devices. Sensors of the cover device, such as one or more alignment sensors, one or more plunger sensors, and position sensors, such as one or more optical sensors, load sensors, linear potentiometers, optical encoders, rotary encoders, magnetic potentiometers, thin film potentiometers, etc., can be configured to have consistent and / or predictable outputs during the working life of the cover device.

[0060] Thirteenth, some embodiments described herein provide controlled sensor movement that can provide reliable and repeatable detection. For example, the electric drive system can drive the sensor bracket substantially independently of manual input or movement. In some embodiments, the electric drive system can drive the sensor bracket at different speeds, multiple directions, etc. to improve detection. Alternatively or in addition, after engagement between the cover device and the liquid delivery device, the movement of the sensor bracket can be delayed for a predetermined period of time to facilitate measurement when the system is subjected to little or no movement or external force.

[0061] The details of one or more embodiments are set forth in the accompanying drawings and the description below. Other features and advantages will be apparent from the description and drawings, and from the claims. BRIEF DESCRIPTION OF THE DRAWINGS

[0062] Figure 1 is an exploded perspective view of an exemplary liquid delivery system.

[0063] Figure 2A is a partial cross-sectional perspective view of a liquid delivery system with a sensor bracket in a first position.

[0064] Figure 2B is a partial cross-sectional perspective view of the liquid delivery system with the sensor bracket in an intermediate position.

[0065] Figure 2C is a partial cross-sectional perspective view of the liquid delivery system with the sensor bracket in a second position.

[0066] Figure 3 is a partial cross-sectional perspective view of the liquid delivery system with the liquid delivery device disengaged from the cap device.

[0067] Figure 4 is a flow chart of an exemplary method of detecting alignment and status of a fluid delivery device.

[0068] Figure 5 is a flow chart of an exemplary method of detecting engagement and / or alignment of a fluid delivery device relative to a cap device.

[0069] Fig. 6A An exemplary position of the liquid delivery device relative to the cover device and an exemplary display interface of the cover device are schematically shown.

[0070] Figure 6B Another exemplary position of the liquid delivery device relative to the cover device and another exemplary display interface of the cover device are schematically shown.

[0071] Figure 7 is a partial cross-sectional perspective view of a cap assembly and a fluid delivery device illustrating a predetermined feature of the fluid delivery device detected by a sensor of the cap assembly when the fluid delivery device is engaged with the cap assembly in a predetermined alignment position.

[0072] Figure 8 is a cross-sectional perspective view of a cap device and a fluid delivery device illustrating an exemplary feedback structure for generating mechanical feedback indicative of radial alignment of the fluid delivery device relative to the cap device.

[0073] Fig. 9 is a flow chart of an exemplary method for displaying information on a cover device. DETAILED DESCRIPTION

[0074] refer to Figure 1 and 2A -C, shows an exemplary liquid delivery system 10 that can be used for storing and delivering liquid and outputting dosage information to a user.Liquid delivery system 10 includes a cap device 100 and a liquid delivery device 200. The cap device 100 can be positioned on at least a portion of the liquid delivery device 200 for storing the liquid delivery device 200 between uses. In an exemplary embodiment, the cap device 100 includes one or more sensors, and the one or more sensors are configured to detect the position of the liquid delivery device 200 and / or the state of the liquid delivery device 200 (for example, the position of its plunger). The cap device 100 may also include one or more output devices, such as a display, a communication system, etc., which are configured to output information related to the position of the liquid delivery device 200 and / or the state of the liquid delivery device 200.

[0075] Liquid delivery device 200 can be configured to deliver the liquid of measuring dosage to experimenter for the treatment of medical condition.For example, liquid delivery device 200 can be a pen-type injector, which is used to deliver liquid (such as insulin) to manage diabetes.In an exemplary embodiment, liquid delivery device 200 includes reservoir 201, delivery end 202, plunger 205 and dial plate 206. Reservoir 201 contains liquid that can be injected at delivery end 202. Delivery end 202 provides a part on which cover device 100 can be placed to store liquid delivery device 200 between use. The delivery end 202 of liquid delivery device 200 includes diaphragm 203 and injection needle 204. Plunger 205 is operable to deliver a certain dose of liquid together with reservoir 201 through delivery end 202. For example, required dose can be measured by operating dial plate 206 (for example, by manually rotating dial plate 206), and required dose is delivered by advancing plunger 205. The plunger 205 is advanced via a rod (not shown) to push a measured dose of liquid from the reservoir 201 into the subject through the delivery end 202. In an exemplary embodiment, the plunger 205 is advanced a specific distance such that a corresponding volume of liquid is dispensed from the liquid delivery device 200.

[0076] The cap device 100 may include a body 110 , one or more sensors 120 , an interface assembly 130 , a sensor bracket 140 , a sleeve 150 , and a motorized drive system 160 .

[0077] The main body 110 is configured to accommodate the various components of the cover device. The main body 110 defines a cavity 111, and the cavity 111 is configured to receive at least a portion of the liquid delivery device 200, such as at least a portion of the delivery end 202 and / or the reservoir 201. The cover device 100 can be positioned above the delivery end 202, and can keep the liquid delivery device 200 (for example, between use periods). The cover device 100 can protect the delivery end 202 from damage or contamination of the external environment, and includes an injection needle 204. The liquid delivery device 200 can be removed from the cavity 111 of the cover device 100 before each use, and then engaged with the cover device 100 after the dose has been delivered. Therefore, the cover device 100 can be removed from the liquid delivery device 200 and replaced on the liquid delivery device 200 for many times. After the content of the specific liquid delivery device 200 is discharged, the liquid delivery device 200 can be discarded, and the cover device 100 can be used together with a new liquid delivery device. In some exemplary embodiments, the liquid delivery device 200 can be discarded when the usable contents of the liquid delivery device 200 are drained, and the cap device 100 can be reused with multiple liquid delivery devices 200. In other exemplary embodiments, the cap device 100 can be associated with a specific liquid delivery device 200, and the cap device 100 and the liquid delivery device 200 can be discarded when the contents of the reservoir 201 are drained. In other exemplary embodiments, the cap device 100 can be associated with a specific liquid delivery device 200, and the liquid delivery device 200 can be refilled when the contents of the reservoir 201 are drained or the reservoir 201 is replaced.

[0078] In various exemplary embodiments, the body 110 is a molded body, such as molded plastic. The body 110 may include a plurality of body portions, such as a body portion 110a and a cover portion 110b, assembled to form the body 110. In other exemplary embodiments, the body 110 may be made as a single piece defining the cavity 111.

[0079] One or more of the sensors 120 in the cap device 100 are configured to detect the position of the liquid delivery device 200 within the cap device 100. In an exemplary embodiment, the cap device 100 includes one or more sensors that output sensor signals that can be evaluated to detect the axial and / or radial position of the liquid delivery device 200 relative to the cap device 100. For example, the sensors can be used to determine that the liquid delivery device 200 is engaged at a predetermined axial and / or radial position relative to the cap device 100, thereby allowing the state of the liquid delivery device 200 to be accurately measured.

[0080] In addition, one or more of the sensors 120 may also detect the state of the liquid delivery device 200. In an exemplary embodiment, the cap device 100 includes one or more sensors 120 that output sensor signals that can be evaluated to detect the plunger 205, the position of the plunger 205, the change in position of the plunger 205 between successive engagements with the cap device 100 (e.g., a change in position after a dose is delivered), and / or other states of the liquid delivery device 200. The position of the plunger 205 and / or the change in position of the plunger 205 may be used to monitor the volume of the dose delivered by the liquid delivery device 200, the total volume of liquid remaining in the reservoir 201, the number of doses remaining in the reservoir 201, the duration remaining before the reservoir 201 is emptied, and / or other information related to the liquid delivery device 200.

[0081] In some embodiments, at least one of the sensors for detecting the state of liquid delivery device 200 may be configured to further detect the position of liquid delivery device 200. In other embodiments, the sensor for detecting the state of liquid delivery device 200 may be different from the sensor for detecting the position of liquid delivery device 200. For example, sensor 120 may include a plurality of sensors, such as first sensor 142 and second sensor 143. In some embodiments, first sensor 142 is used to detect the position (e.g., radial position) of liquid delivery device 200, and second sensor 143 is used to detect the state of liquid delivery device 200. In some embodiments, first sensor 142 is used to detect the position (e.g., radial position) of liquid delivery device 200, and first sensor 142 and / or second sensor 143 can be used to detect the state of liquid delivery device 200. For example, first sensor 142 or second sensor 143 can be used to detect the state of liquid delivery device 200, depending on which sensor is located along a predetermined line of sight based on the radial position of liquid delivery device 200. Alternatively or additionally, the first sensor 142 and the second sensor 143 can be used together to confirm each other and promote the reliable determination of the state of liquid transport device 200. In certain embodiments, the state of liquid transport device 200 can be detected only when it is detected that liquid transport device 200 is arranged in a predetermined position (e.g., axially and / or radially aligned). For example, until it is detected that liquid transport device 200 is arranged in a predetermined position, the state of liquid transport device 200 is detected by using a sensor. In other embodiments, before liquid transport device 200 is arranged in a predetermined position (e.g., axially and / or radially aligned), it can be detected or no matter whether the liquid transport device is arranged in a predetermined position, the state of liquid transport device 200 is detected.

[0082] The sensor detecting the axial position (e.g., axial alignment) can be a sensor that detects engagement with a snap-in feature, or a sensor type that detects whether the cover device is fixed to the liquid delivery device. As described below, the cover device may include a mechanical feedback device (e.g., a spring-biased axial column 302 that is configured to provide a click sense or a sense of snapping in when engaged) and a sensor coupled to the mechanical feedback device (e.g., a mechanical switch or other type of sensor that is configured to detect when the spring-biased axial column is engaged by the liquid delivery device). The example of a sensor for axial position detection is further described in U.S. Patent No. 8,743,662 and U.S. Provisional Application No. 62 / 667,085, the disclosure of which is fully incorporated herein to an appropriate degree.

[0083] The sensor that detects radial position (e.g., radial alignment) can be a sensor that detects engagement with a snap-in feature that allows the liquid delivery device to snap into the cover device at a predetermined radial position. As described below, the cover device may include a mechanical structure (e.g., a radial retaining structure 800 with a detent 802) that is configured to radially fix the liquid delivery device and generate mechanical feedback (e.g., a click or snap-in feel when engaged). In addition, the cover device may include a sensor, such as a mechanical switch or other type of sensor, that is configured to detect when the mechanical structure is properly engaged by the liquid delivery device.

[0084] The sensor detecting the axial position and / or radial position may be of various types, such as an optical sensor, a mechanical switch or other suitable type for determining such position of the liquid delivery device relative to the cover device.

[0085] In various exemplary embodiments, the first sensor 142 and the second sensor 143 are sensors of the same type. In some exemplary embodiments, the first sensor 142 is different from the second sensor 143 in one or more characteristics. For example, the first sensor 142 may have a sensor resolution or accuracy different from the second sensor 142. For example, the first sensor 142 for detecting the position of the liquid delivery device 200 may have a lower sensor resolution or accuracy than the second sensor 143 for detecting the state of the liquid delivery device 200. For example, lower resolution or accuracy can help reduce the overall cost of the cap device 100 and / or improve calibration efficiency. In some embodiments, the first sensor 142 or the second sensor 143 (or both) can be used to detect the position and state of the liquid delivery device 200.

[0086] At least one of the sensors 120 may be supported by a sensor bracket 140 movably disposed in the cover device 100. For example, when the position sensor 145 is fixedly disposed in the cover device 100, the first sensor 142 and the second sensor 143 are carried by the sensor bracket 140 and may move together with the sensor bracket. The position sensor 145 may be configured to detect an axial position or distance of the sensor bracket 140 relative to the cover device 100.

[0087] The sensor 120, such as the first sensor 142 and the second sensor 143, is configured to output a sensor signal representing a characteristic of the liquid delivery device 200. The output signal from the sensor can vary according to the physical characteristics of the liquid delivery device 200 encountered by the sensor, and therefore the output signal can be different at different axial and / or radial positions relative to the liquid delivery device 200. For example, when the liquid delivery device 200 rotates relative to the cap device 100 (e.g., when the user positions the cap device 100 on the liquid delivery device 200), the change in the output signal of the sensor (e.g., sensor 142) can be evaluated to determine one or more predetermined features of the liquid delivery device 200 (e.g., the distal edge or chamfer of the reservoir window), which can indicate that the liquid delivery device 200 is in a predetermined position (e.g., predetermined radial alignment). In addition, when the sensor bracket 140 moves relative to the liquid delivery device 200, the change in the output signal of the sensor (e.g., sensor 142 and / or sensor 143) can be evaluated to determine the leading edge of the front end of the reservoir 201 (e.g., at the delivery end 202), the leading end of the plunger 205, the trailing end of the plunger 205, and / or other properties of the liquid delivery device 200. The position change detected between a series of doses, for example, the position change of the plunger 205 before the dose is delivered and after the dose has been delivered, can be used to evaluate the dose volume delivered by the liquid delivery device 200, the total volume of liquid remaining in the reservoir 201, the number of doses remaining in the reservoir 201, the duration remaining before the reservoir 201 is emptied, the time of the previous dose (e.g., the time when the cover device 100 is replaced on the liquid delivery device 200), the time elapsed since the last dose (e.g., the time elapsed since the cover device 100 is replaced on the liquid delivery device 200), and / or other information related to the liquid delivery device 200. Alternatively or additionally, the relative position of one or more of the detected features, or the distance between one or more of the detected features, may be used to assess dosage information associated with the fluid delivery device 200 .

[0088] In an exemplary embodiment, the sensor 142 includes an emitter 142a and a receiver 142b, such as a light emitter 142a and a light receiver 142b. The light emitter 142a emits radiation that can be detected by the light receiver 142b, and in some embodiments the light emitter 142a may include an LED or a laser diode. The sensor 142 may output a sensor signal related to the amount of radiation received by the light receiver 142b (e.g., the amount of radiation received from the light emitter 142a). Thus, the sensor signal may depend on the path 142c between the light emitter 142a and the light receiver 142b (e.g., Figure 2A-2C ) in the liquid delivery device 200. Thus, for example, when different structures, plungers or other solid structures are present in the path 142c, the amount of radiation received by the light receiver may be relatively low, and when only the transparent wall of the reservoir and its liquid contents are present in the path 142c, the amount of radiation received by the light receiver may be relatively high.

[0089] The emitter 142a and the receiver 142b may be arranged in alignment with each other such that an optical path 142c between the emitter 142a and the receiver 142b extends perpendicular (e.g., substantially perpendicular, within 10° of exact perpendicular) to the central longitudinal axis A of the cavity 111. In some embodiments, the emitter 142a is configured to produce a narrow light beam with limited expansion out of the optical path 142c, for example by the emitter 142a emitting the narrow light beam and / or by a collimating structure configured to focus the output of the emitter 142a along the path 142c. In various exemplary embodiments, the radiation emitted by the emitter 142a may be in the visible wavelength range and / or in the invisible wavelength range.

[0090] In some exemplary embodiments, the sensor 142 can be a reflective sensor that detects reflected light. The reflective sensor 142 can detect a color transition indicative of the plunger 205, such as a transition from a relatively high transparency and / or light color of the liquid and / or reservoir 201 to a relatively low transparency and / or dark color (e.g., red, orange, black, etc.) of the plunger 205.

[0091] In the exemplary embodiment, sensor 143 is configured similarly to sensor 142, including a transmitter 143a and a receiver 143b that define a path 143c.

[0092] Still reference Figure 1, the interface component 130 of the cover device 100 includes various components for calculating, displaying, storing and / or communicating the sensor signal that can be output by the sensor 120. In an exemplary embodiment, the interface component 130 includes a display 121, a user input device 122, a communication interface 123, a memory 124, a processor 125, a speaker 126, and a vibrator 128. One or more components may be electrically connected to one or more other components via a circuit board 127. The processor 125 may be configured with logic to control the operation of one or more components and process the sensor signal received from the sensor 120 of the cover device 100. At least one of the interface component and the other components may be housed in the housing 110.

[0093] In certain embodiments, display 121 provides the user with the visual output related to the position of liquid delivery device 200 relative to cover device 100 and / or the state of liquid delivery device 200 and / or the state of cover device 100. For example, display 121 can be an LED or LCD display. In certain embodiments, display 121 can provide the visual indication related to the axial and / or radial position of liquid delivery device 200 relative to cover device 100. In addition, display 121 can provide the visual indication related to the following items: the dosage volume delivered by liquid delivery device 200, the total volume of liquid remaining in reservoir 201, the dosage quantity remaining in reservoir 201, the duration remaining before reservoir 201 is emptied, the time of previous dosage (for example, the time when cover device 100 is replaced on liquid delivery device 200), the time passed since the last dosage (for example, the time passed since cover device 100 is replaced on liquid delivery device 200) and / or other information related to liquid delivery device 200.

[0094] Alternatively or additionally, the cover device 100 may include an audio and / or vibration alarm associated with the position of the liquid delivery device 200 relative to the cover device 100 and / or the state of the cover device 100 and / or the liquid delivery device 200. The processor 125 may control the audio output of the speaker 126 to output an audible alarm, or control the vibrator 128 to output a vibration alarm, which may be considered as an indication of the axial and / or radial position of the liquid delivery device 200 relative to the cover device 100. In addition, such audible alarms or vibration alarms may be used to provide indications of the following: the dose volume delivered by the liquid delivery device 200, the total volume of liquid remaining in the reservoir 201, the number of doses remaining in the reservoir 201, the duration remaining before the reservoir 201 is emptied, the time of the previous dose (e.g., the time when the cover device 100 is replaced on the liquid delivery device 200), the time passed since the last dose (e.g., the time passed since the cover device 100 is replaced on the liquid delivery device 200) and / or other information associated with the liquid delivery device 200. Alternatively or additionally, the vibrator 128 can deliver vibrations to the liquid delivery device 200. The vibrator 128 can be activated to promote mixing of the contents of the liquid delivery device 200 and / or reduce the formation or accumulation of sediment (e.g., on the front surface of the plunger and / or the surface of the reservoir 201).

[0095] The user input device 122 is configured to facilitate user interaction with the cover device 100. In an exemplary embodiment, the user input 122 includes one or more buttons, switches or other control interfaces operable to control the cover device 100. For example, the user input device 122 can be operated by the user to activate the cover device 100 and / or select information to be displayed by the display 121. As described herein, in some embodiments, the cover device 100 can be automatically activated by engaging with the liquid delivery device 102. Alternatively or additionally, for example, when the cover device 100 is engaged with a new liquid delivery device 200, the user input device 122 can be operated to reset the settings and / or memory 124 of the cover device 100. In some exemplary embodiments, the cover device 100 does not include the user input device 122. The cover device 100 that does not include the user input device can contribute to the perception of the fully automatic cover device 100 and / or improve the user operability.

[0096] The cover device 100 can communicate with one or more other components of the liquid delivery system to deliver and / or receive information related to the position of the liquid delivery device 200 relative to the cover device 100 and / or the state of the cover device 100 and / or the liquid delivery device 200. For example, the communication device 123 of the cover device 100 is configured to communicate with one or more components away from the cover device 100. The communication device 123 may include a wireless communication printed circuit assembly configured for wireless communication via, for example, short wavelength UHF radio frequency, RF communication, WI-FI, Bluetooth, ZIGBEE, etc. Alternatively or additionally, the communication device 123 may include an electrical port for wired communication with another electronic device. In various exemplary embodiments, the communication device 123 is configured for two-way communication, such as two-way communication with a mobile device having software configured to deliver and receive communication with the cover device 100. Alternatively, the cover device 100 may be configured for one-way communication, such as uploading information only to the mobile device, or receiving information only from the mobile device.

[0097] The communication device 123 can be configured to communicate with an electronic device configured with diabetes management software. For example, the communication device 123 can transmit information related to the liquid delivery device 200, which can be further processed by the electronic device. In this way, the cap device 100 can facilitate a remote user or healthcare provider to review information collected by its sensors, provide alerts related to the liquid delivery system 200 (e.g., related to the scheduled time of injection, a nearly empty liquid delivery device, etc.) through the electronic device, and / or facilitate additional processing and analysis of information collected by the cap device 100.

[0098] The cap device 100 may include a power source 170. In an exemplary embodiment, the power source 170 includes one or more batteries, such as alkaline batteries, nickel-cadmium batteries, lithium-ion batteries, etc. In some embodiments, the power source 170 is associated with an axial position device 300, which is configured to be activated when engaged with a portion of the liquid delivery device 200 axially inserted into the cap device 100. When activated, the axial position device 300 is operable to switch the cap device 100 between an inactive or low-power state and an active or operating state; in the active or operating state, the sensor of the cap device 100 is in an active state. In other embodiments, the power source 170 may be associated with a micro switch, which is configured to switch the cap device between an inactive or low-power state and an active or operating state. Alternatively or additionally, a sensor signal from one or more sensors (e.g., one or more position sensors) of the cap device 100 may provide an alarm to the processor 125 to switch the cap device to an active or operating state.

[0099] Still reference Figure 1The sensor bracket 140 of the cover device 100 is configured to carry one or more sensors 120 and is movably positioned in the cavity 111 of the body 110. In some embodiments, the sensor bracket 140 is configured to travel axially along at least a portion of the liquid delivery device 200 in the cavity 111. The size of the cavity 111 can be set to accommodate the size of the liquid delivery device 200 and the path of the sensor bracket 140.

[0100] The sensor bracket 140 facilitates detecting a characteristic, such as a position and / or state of the liquid delivery device 200, by carrying one or more sensors along the liquid delivery device 200 between a first position and a second position. In an exemplary embodiment, the sensor bracket 140 is movable between the first position and the second position relative to the cavity 111 when the liquid delivery device 200 is maintained in a fixed position relative to the cavity 111 (e.g., the sensor bracket 140 is movable when the liquid delivery device 200 is fixedly engaged with the cover device 100). Referring to FIG. 2- Figure 4 , such exemplary movable positions of the sensor bracket 140 are shown and described in more detail.

[0101] The sensor bracket 140 may include a plurality of sensors, such as a first optical sensor 142 and a second optical sensor 143. In some embodiments, one of the plurality of sensors (e.g., one of the first optical sensor 142 and the second optical sensor 143) may be used to detect the radial position of the liquid delivery device relative to the cover device. For example, as described above, the first sensor 142 is configured to detect the radial position of the liquid delivery device, and the second sensor 143 is configured to detect the state of the liquid delivery device (e.g., plunger position).

[0102] The first optical sensor 142 includes a first emitter 142a and a first receiver 142b, and the second optical sensor 143 includes a second emitter 143a and a second receiver 143b. The first emitter 142a may be aligned with the first receiver 142b, and the second emitter 143a may be aligned with the second receiver 143b (e.g., such that the first receiver 142b primarily or exclusively receives radiation from the first emitter 142a, and the second receiver 143b primarily or exclusively receives radiation from the second emitter 143a). For example, the first emitter 142a and the second receiver 143b, and the second emitter 143a and the first receiver 142b are not aligned and do not define an optical path perpendicular to the longitudinal axis of the cavity 111. Alternatively, the first emitter 142a may be aligned with the second receiver 142b for sensing, and / or the second emitter 143a may be aligned with the first receiver 143b for sensing. In an exemplary embodiment, the first transmitter 142a and the second transmitter 143a and the first receiver 142b and the second receiver 143b are spaced 90 ° from each other around the circumference of the sensor bracket 140. Therefore, the first sensor 142 and the second sensor 143 can define a first path 142c and a second path 143c perpendicular to each other. In certain embodiments, the first path 142c and / or the second path 143c do not intersect with the central longitudinal axis of the cavity 111 or the central longitudinal axis of the liquid delivery device 200. The first path 142c and / or the second path 143c that do not intersect with the central axis can help to detect the rear surface 205b of the plunger 205 by avoiding the rod of the plunger from blocking. Although the first sensor 142 and the second sensor 143 are mainly described as optical sensors, one or both of them can be other types of sensors. For example, the first sensor 142 can be configured to detect the radial position of the liquid delivery device, and the first sensor 142 can be configured as a mechanical switch, which can be used to determine whether the liquid delivery device is buckled into the predetermined radial position in the cover device.

[0103] In various exemplary embodiments, the relative radial position of sensor 142 relative to liquid delivery device 200 can determine whether there is a suitable line of sight through reservoir 201, thereby determine the accurate determination of plunger 205 position, which can be used to determine the amount of liquid remaining in the liquid delivery device. Some embodiments of the cover device are configured to be compatible with various types of liquid delivery devices, wherein each liquid delivery device has various features (e.g., frame, mark, protrusion, number, hash line and other blocking) at different positions. Depending on the radial position of the liquid delivery device relative to the cover device, the position of such features may block or distort the light from emitter 142a, making the leading edge and / or trailing edge of plunger 205 fuzzy or difficult to determine, thereby affecting the reliability of the determination of the residual liquid amount in the liquid delivery device 200 and / or the reliability of the determination of the liquid dosage in the liquid delivery device 200. The radial alignment position can be determined so that such features of each liquid delivery device neither block the sensor detection plunger nor distort the viewing of the plunger. The radially aligned position of the liquid delivery device relative to the cap device provides an optimal optical path across the reservoir along the entire length of the reservoir, allowing the plunger to be viewed and detected at any position along the length of the reservoir.

[0104] In some embodiments where there are multiple optical sensors 142, 143, each transmitter 142a, 143a may emit a different wavelength, and the receivers 142b, 143b may likewise be wavelength specific, for example by including a bandpass filter. Alternatively or additionally, each sensor may emit and detect radiation pulses at different time periods of a cycle (e.g., using time division multiplexing). In some embodiments, the sampling rate may be greater than 100 Hz, greater than 1000 Hz, or higher.

[0105] Alternatively or additionally, as sensors 142, 143, sensor bracket 140 may also include a position sensor 145, which is configured to output a sensor signal indicating a position or distance. In an exemplary embodiment, cap device 100 includes a position sensor 145, which outputs a sensor signal indicating the position of sensor bracket and / or the distance of sensor bracket traveling between a first position and a second position (e.g., when sensor bracket 140 moves along liquid delivery device 200 or moves between subsequent doses of liquid delivery device 200). In an exemplary embodiment, position sensor 145 includes a linear potentiometer. The resistor element is at least partially positioned along the length of cavity 111, for example, at the sidewall of main body 110 or sleeve 150. A scraper may be located on sensor bracket 140.

[0106] The position sensor 145 can output a sensor signal (e.g., a voltage) that varies depending on the position of the blade along the resistive element (e.g., and the position of the sensor bracket 140 along the cavity 111). For example, a specific voltage can be associated with a specific position along the resistive element, and the voltage can be consistent and repeatable each time the blade travels along the resistive element. The sensor 145 can have a unique voltage output characteristic for each position of the blade and can be calibrated to achieve highly accurate and repeatable measurements.

[0107] Alternatively or additionally, as a linear potentiometer, position sensor 145 may include one or more other sensor types that provide an indication of position that may be related to the sensor signals output by sensor 142 and / or sensor 143. For example, position sensor 1145 may include a linear encoder, a rotary encoder, a magnetic potentiometer, a membrane potentiometer, a load cell, etc.

[0108] Still reference Figure 1 , the sleeve 150 of the cover device 100 is configured to be at least partially arranged in the cavity 111 of the body 110 and receive at least a portion of the liquid delivery device 200. The sleeve 150 may include a main wall 152 and a front wall 154, the front wall 154 extending axially from the main wall 152 and configured to receive the delivery end 202 and / or the injection needle 204 of the liquid delivery device 200. The sleeve 150 at least partially surrounds the injection needle 204 (e.g., close to the front of the cover device 100) and the reservoir 201 between the injection needle 204 and the opening 114 of the body 110. The sensor bracket 140 can move between the sleeve 150 and the inner wall of the body 110, and during the operation of the sensor bracket 140, the sleeve 150 can be located between the liquid delivery device 200 and the sensor bracket 140.

[0109] Alternatively or additionally, the sleeve 150 may include one or more retaining features that engage with the liquid delivery device 200 and limit axial and / or radial movement of the liquid delivery device 200 relative to the body 110 of the cap device 100. As described herein, embodiments of retaining features may include an axial position device 300, a portion of the sleeve 150 (e.g., the flange wall 158 thereof), and a radial retaining structure 800.

[0110] In some embodiments, the sleeve 150 includes a track 156 configured to guide and / or limit the movement of the sensor bracket 140. In an exemplary embodiment, the track 156 is configured as one or more guides that engage with complementary features (e.g., axial grooves) of the sensor bracket 140. In the illustrated embodiment, the track 156 includes two guides that extend axially along at least a portion of the length of the sleeve 150 and are arranged opposite each other on the exterior of the sleeve 150. The track 156 defines a path along which the sensor bracket 140 travels, for example in a longitudinal direction between a first position proximate to the front wall 112 of the body 110 and a second position closer to the opening 114 of the body 110.

[0111] The electric drive system 160 operates to drive the sensor bracket 140 along the longitudinal axis of the cover device 100, such as along the longitudinal axis extending centrally through the front wall 112 and the opening 114 of the body 110. For example, the electric drive system 160 includes a motor 161 and a lead screw 162 directly or indirectly connected to the drive shaft of the motor 161. The motor 161 can be mounted to a motor mounting block 172, which is located in the cavity 111 and near the front wall 112 of the body 110. The rotation of the lead screw 162 caused by the operation of the motor 161 causes the sensor bracket 140 to move axially. The rotation of the motor 161 in a first direction causes the sensor bracket 140 to move toward the opening 114 of the cavity 111, and the rotation of the motor 161 in a second, opposite direction causes the sensor bracket 140 to move toward the front wall 112 of the body 110. In an exemplary embodiment, the electric drive system 160 can thus drive the sensor bracket 140 between any number of discrete points along the lead screw 162.

[0112] Although the operation of the lid device 100 using the electric drive system 160 is primarily described herein, it should be understood that the principles and configurations disclosed herein are also applicable to other types of lid devices, such as non-electric lid devices.

[0113] Reference now Figure 2A , 2B and 2C, the movable sensor bracket 140 is shown in a first position ( Figure 2A ), middle position( Figure 2B ) and the second position ( Figure 2C). When the liquid delivery device 200 is at least partially received in the main body 110, the sensor bracket 140 can be moved to any position from the first position to the second position, or vice versa. In some embodiments, when the liquid delivery device 200 remains fixedly positioned relative to the main body 110 of the cover device 100, the sensor bracket 140 can move between the first position and the second position. The movement of the sensor bracket 140 between the first position and the second position helps to detect the characteristics of the liquid delivery device 200 at multiple positions of the liquid delivery device 200. When the sensor bracket 140 moves between the first position and the second position, the sensors 142 and 143 can generate output signals continuously or at a relatively high frequency (e.g., between 0.1kHz and 100kHz, between 5kHz and 50kHz, or about 30kHz). In some embodiments, as the sensor bracket 140 travels between the first position and the second position, the operation of sensors 142 and 143 can be described as generating a scan of a portion of the fluid delivery device 200, and output signals from sensors 142 and 143 (e.g., alone or in combination with one or more sensors, such as position sensor 145) can be evaluated to determine the position of the plunger 205 within the reservoir 201, changes in the position of the plunger 205 within the reservoir 201, and / or other states of the fluid delivery device 200.

[0114] Additionally or alternatively, the sensor bracket 140 may be moved to a predetermined position (i.e., a radial alignment detection position) at which the sensor 142 of the sensor bracket 140 is configured to detect the radial position of the liquid delivery device 200 engaged with the cap device 100. As described herein, when the sensor bracket 140 is arranged in the radial alignment detection position between the first position and the second position, the sensor 142 of the sensor bracket 140 is operable to detect a predetermined feature of the liquid delivery device 200 (e.g., one of the relative axial tips, edges, and / or other features of the window 220 formed in the reservoir 201) to determine that the liquid delivery device 200 is in a desired radial position (i.e., a radial alignment position) relative to the cap device 100.

[0115] In some embodiments, the radial alignment detection position of the sensor bracket 140 is arranged near the first position ( Figure 2A In other embodiments, the radial alignment detection position is the same as the first position. In still other embodiments, the radial alignment detection position is arranged near the second position or the same as the second position ( Figure 2C In still other embodiments, the radial alignment detection position may be any position between the first position and the second position.

[0116] In different embodiments, the sensor bracket 140 may be configured to be initially arranged in different positions. In an exemplary embodiment, the sensor bracket 140 may be configured to be arranged in a first position as a default position and return to the first position after one or more operations in different positions. Alternatively or additionally, the sensor bracket 140 may be configured to be arranged in a radial alignment detection position as a default position and return to the radial alignment detection position after one or more operations in different positions. In some embodiments, the sensor bracket 140 may be configured to be arranged in a second position as a default position and return to the second position after one or more operations in different positions. In yet other embodiments, other positions of the sensor bracket 140 may be used as the default position.

[0117] The sensor bracket 140 may return to its default position at any time, for example, shortly after the liquid delivery device 200 is engaged with the cover device 100, after one or more predetermined processes (e.g., a scanning process in which the sensor bracket 140 moves between a first position and a second position to detect the position of the plunger 205) are completed, and / or shortly after the liquid delivery device 200 is removed from the cover device 100.

[0118] exist Figure 2A In the first position shown, the sensor bracket 140 is located near the front wall 112 of the body 110. In some embodiments, the sensor bracket 140 can be introduced into the first position by inserting the liquid delivery device 200 into the cavity 111. In other embodiments, the sensor bracket 140 can be arranged in the first position by default before the liquid delivery device 200 is inserted into the cavity 111.

[0119] The sensor bracket 140 can be moved from the first position toward the second position by the electric drive system 160. When the sensor bracket 140 moves along the liquid delivery device 200 between the first position and the second position, the sensor 142 of the sensor bracket 140 can output a sensor signal. Figure 2A In the first position shown, the field of view 142c (e.g., or optical path or line of sight) between the transmitter 142a and the receiver 142b intersects the delivery end 202 of the liquid delivery device 200, or intersects a portion of the liquid delivery device 200 near the delivery end 202. The sensor signal can be evaluated (e.g., by the processor 125) to detect the presence of the front end of the reservoir 201. In some embodiments, a specific amplitude of the sensor signal or an increase in the amplitude of the sensor signal can therefore provide an indication of the front end of the reservoir 201.

[0120] Figure 2BThe sensor bracket 140 is shown in an intermediate position between the first position and the second position. The field of view 142c between the emitter 142a and the receiver 142b passes through the intermediate position of the reservoir 201. The walls of the reservoir 201 and the liquid within the reservoir 201 can provide a relatively low opacity for the transmission of radiation between the emitter 142a and the receiver 142b, so that the sensor signal is relatively high in the intermediate position.

[0121] Figure 2C The sensor bracket 140 is shown in a second position, in which the sensor bracket 140 is located proximate the opening 114 of the cavity 111. In the second position, the sensor bracket 140 has traveled beyond the front surface 205a of the plunger 205, so that the field of view 142c intersects the plunger 205. The presence of the front surface 205a can be detected by a change in the sensor signal at the location where the field of view 142c encounters the front surface 205a. For example, the amplitude of the radiation received by the receiver 142b can be reduced or lowered due to the presence of the plunger 205 in the path 142c.

[0122] After advancing beyond the front surface 205a of plunger 205, sensor 142 can continue to detect the characteristic of liquid transport device 200.For example, rear surface 205b can be detected based on the change of sensor output at the position where rear surface 205b intersects with path 142c.For example, owing to the plunger 205 that does not intersect with path 142c, the amplitude of the radiation received by receiver 142b can be increased or enhanced.The length of plunger 205 between front surface 205a and rear surface 205b is fixed, and therefore the position of plunger 205 can be assessed using front surface 205a or rear surface 205b.Detecting the front surface 205a and rear surface 205b of plunger 205 can improve the accuracy of assessing plunger 205.For example, even if another feature (such as frame, mark, etc.) of liquid transport device 200 blocks front surface 205a or rear surface 205b, the position of plunger 205 can also be accurately located.

[0123] The position of the plunger 205 or the change in position of the plunger 205 can be evaluated in conjunction with the sensor signal output by the position sensor 145. In an exemplary embodiment, when the sensor bracket 140 moves between the first position and the second position, the sensor signal generated by the position sensor 145 changes in a predictable manner. For example, the sensor signal of the position sensor 145 for a specific position can be associated with the sensor signal of the sensor 142 from the specific position. The change in position of the plunger 205 before and after the dose has been delivered can be detected, as well as the volume of the delivered dose calculated based on the change in position. Alternatively or additionally, the distance between the positions associated with the various output signals from the sensor 142, such as the distance between the front end of the reservoir 201 and the front surface 205a of the plunger 205, and the remaining volume of the reservoir 201 calculated based on the distance can be evaluated.

[0124] refer to Figure 3 , an exemplary axial position device 300 is shown when the liquid delivery device 200 is not located in the body 110 of the cap device 100. The axial position device 300 is configured to engage a portion of the liquid delivery device 200 when the liquid delivery device 200 is axially inserted into the cap device 100. The axial position device 300 is configured to provide mechanical feedback when the liquid delivery device 200 is inserted into a predetermined axial position in the cavity 111 of the body 110. For example, the sleeve 150 includes a flange wall 158, which is formed between the main wall 152 and the front wall 154 and is configured to engage with the front end 208 (e.g., the delivery end 202) of the liquid delivery device 200 to limit the axial movement of the liquid delivery device 200 in the cavity 111 of the body 110. The axial position device 300 is configured to provide mechanical feedback to a user grasping the fluid delivery device 200 and / or the cap device 100 when the leading end of the fluid delivery device 200 is about to engage the flange wall 158 of the sleeve 150 .

[0125] In some embodiments, the axial position device 300 may include a longitudinal column 302 movably mounted to the motor mounting block 172. A spring 304 may be engaged between the rear portion of the column 302 and a portion of the motor mounting block 172 to bias the column 302 toward the motor mounting block 172 (i.e., toward the cavity 111 or the sleeve 150 in a direction opposite to the direction of inserting the liquid delivery device 200). The distal end 306 of the column 302 extends through the flange wall 158 of the sleeve 150 and extends into the space surrounded by the main wall 152 of the sleeve 150. Therefore, the front end 208 of the liquid delivery device 200 contacts the distal end 306 of the column 302 and overcomes the biasing force of the spring 304 to push the column 302. In some embodiments, the column 302 can be pushed back against the spring 304 until the front end 208 of the liquid delivery device 200 abuts against the flange wall 158 of the sleeve 150.

[0126] Additionally or alternatively, the axial position device 300 is configured to detect the axial engagement of the liquid delivery device 200 with the cap device 100. For example, the axial position device 300 includes one or more switches or sensors configured to detect the post 302 pushed by the liquid delivery device 200 and to generate a sensor signal indicating the axial engagement of the liquid delivery device 200 relative to the cap device 100 (e.g., sleeve 150). In response, the cap device 100 can be activated / powered on, and / or one or more operations can be initiated, such as detecting the radial position of the liquid delivery device 200.

[0127] Various exemplary cap devices described herein can facilitate efficient and repeatable techniques for assessing the position (eg, alignment) and / or status of a fluid delivery device. Figure 4 , a flow chart of an exemplary method 400 for detecting the alignment and state of a liquid delivery device is shown. Method 400 includes an operation 402 of receiving at least a portion of a liquid delivery device in a cavity of a cap device. In various exemplary embodiments, the liquid delivery device may have features and characteristics similar to the liquid delivery device 200 described herein, and may be a pen-type injector device for administering a dose of insulin. The cap device may have features and characteristics similar to the cap device 100 described herein.

[0128] Operation 402 may include axial insertion in the cavity of the cover device and / or make the liquid transporting device rotate radially relative to the cover device, until the liquid transporting device axial engagement / alignment and / or radial alignment (for example, the central longitudinal axis of the liquid transporting device is aligned with the central longitudinal axis of the cover device cavity), and / or the liquid transporting device is aligned with respect to the radial position of the cover device cavity.Alternately or additionally, the liquid transporting device can be aligned to one or more discrete axial and / or radial alignment positions with the cover device.For example, the liquid transporting device and / or the cover device can have asymmetric features, non-circular shapes and / or contribute to other mechanical / geometric features of receiving the liquid transporting device at one or more discrete positions (for example, based on the predetermined position of one or more sensors in the cover device and selected).By reducing the interference or blocking of frame, mark, opaque area and / or other features, the alignment of the liquid transporting device and the cover device on a specific orientation can contribute to the expectation interaction between one or more sensors of the cover device and the liquid transporting device.

[0129] In an exemplary embodiment, the operation 402 of receiving the liquid delivery device using the cavity of the cover device may include fixedly engaging the cover device with the liquid delivery device. For example, after operation 402, the relative motion between the liquid delivery device and the cover device may be limited so that the liquid delivery device cannot rotate in the cavity and / or the liquid delivery device cannot move longitudinally in the cavity.

[0130] Method 400 includes an operation 404 of detecting the alignment of a liquid delivery device. Operation 404 may include detecting that the liquid delivery device is rotated to a predetermined radial position (e.g., radial alignment position) relative to the cover device. The predetermined radial position may be one or more positions that help accurately detect the position and movement of the plunger in the liquid delivery device by the sensor of the sensor bracket in the cover device. Alternatively or additionally, in some embodiments, operation 404 may include determining that the liquid delivery device is inserted into the cover device and placed in a predetermined axial position (i.e., axial alignment position). For example, the cover device includes one or more sensors, and when the liquid delivery device engages with the cover device at such a predetermined axial position, the one or more sensors generate a sensor signal. The predetermined axial position may be such a position: the liquid delivery device is allowed to enter a predetermined radial position when rotating at a predetermined axial position. In other embodiments, operation 404 does not include detecting that the liquid delivery device enters a predetermined axial position. The cover device may be configured to provide mechanical feedback (e.g., axial resistance) when the liquid delivery device approaches a predetermined axial position, and / or to provide an axial structure that prevents the liquid delivery device from moving axially at a predetermined axial position when the liquid delivery device is axially inserted into the cover device.

[0131] When the liquid delivery device is in the predetermined alignment position, the liquid delivery device remains fixedly engaged with the cover device. Relative movement between the liquid delivery device and the cover device can be restricted so that the liquid delivery device cannot rotate within the cavity and / or the liquid delivery device cannot move longitudinally within the cavity. Exemplary operation 404 is further described herein, for example with reference to Figure 5 Exemplary.

[0132] In some embodiments, the radial alignment position may include a plurality of radial alignment positions, each radial alignment position providing a predetermined line of sight for accurate plunger detection. In other embodiments, the radial alignment position may be a single radial alignment position that provides such a predetermined line of sight for accurate plunger detection. Where multiple sensors are used, such multiple sensors (e.g., first sensor 142 and second sensor 143) are used to detect one or more of the plurality of radial alignment positions.

[0133] Method 400 includes providing user guidance to help the user in a predetermined alignment position (e.g., axial and / or radial alignment position) to engage the liquid transport device with the cover device operation 406. In certain embodiments, the cover device includes an output device, such as a display screen, and the output device presents one or more symbols (e.g., marks, text, letters, numbers, etc.) indicating the position state of the liquid transport device relative to the main body. For example, the cover device can display a symbol representing the step of engaging the liquid transport device with the cover device in the predetermined alignment position. In certain embodiments, the cover device displays such symbols until the liquid transport device is detected in such predetermined alignment position. The steps may include first inserting the liquid transport device at least partially axially into the cover device until the liquid transport device is arranged in a predetermined axial position (e.g., the cover device 100 is placed on the liquid transport device 200 so that they are buckled together), then rotating the liquid transport device relative to the cover device until the liquid transport device is detected in a predetermined radial position. For example, corresponding snap-in features may be present in the cap device 100 and the liquid delivery device 200 such that when a user rotates the cap device 200 relative to the liquid delivery device 200 toward a predetermined radial alignment, the cap device 100 and the liquid delivery device 200 snap into a predetermined radial alignment. Example operation 406 is further described herein, for example with reference to Fig. 9 Exemplary.

[0134] In some embodiments, operation 406 may include determining that the liquid delivery device is arranged in a predetermined position relative to the cover device (e.g., a position that can accurately monitor the plunger position to allow accurate determination of the amount of remaining contents in the liquid delivery device), and providing guidance based on such determination. For example, operation 406 may include actively monitoring the position of the liquid delivery device relative to the cover device over time or at regular intervals, and determining whether the liquid delivery device is in axial and / or radial alignment relative to the cover device.

[0135] Method 400 may include operation 408 of driving a sensor carriage including one or more sensors (e.g., sensor 142). Operation 404 may include driving the sensor carriage by an electric drive system including a motor. For example, the electric drive system may drive the sensor carriage from a first position to a second position, or vice versa. When the sensor carriage moves between the first position and the second position, one or more sensor signals located on the sensor carriage operate to output sensor signals indicating one or more characteristics of the liquid delivery device.

[0136] In some exemplary embodiments, operation 408 is performed when the liquid delivery device is in a predetermined alignment position relative to the cover device as determined by operation 404. Alternatively or additionally, even if the liquid delivery device is not determined to be in a predetermined radial alignment position relative to the cover device, but is in a predetermined axial position, operation 408 can also be performed to determine whether the plunger position can be detected, even if the determination is not as accurate as when the liquid delivery device is in a predetermined radial alignment. In some embodiments, operation 408 can be performed before determining that the liquid delivery device is in a predetermined radial alignment position relative to the cover device and after once again determining that the liquid delivery device is in a predetermined radial alignment position. In some cases, after the liquid delivery device is placed in a predetermined axial position, operation 408 can be delayed in time to provide the user with sufficient time to rotate the liquid delivery device 200 relative to the cover device 100 to achieve a predetermined radial alignment, but even if the cover device 100 is not in a predetermined radial alignment, operation 408 can be performed after a predetermined amount of time after the liquid delivery device is placed in a predetermined axial position. If the user subsequently rotates the cap device 100 relative to the liquid delivery device 200 to achieve the predetermined radial alignment, the cap device 100 can again perform operation 408 to determine the position of the plunger and the amount of liquid remaining in the liquid delivery device 200. Subsequent results from operation 408 after achieving the predetermined radial alignment can be compared with earlier results outside of the predetermined radial alignment and / or used to correct, confirm, update, replace, etc. the earlier results.

[0137] In some exemplary embodiments, the operation of driving the sensor bracket 408 can be initiated without additional manual operation. For example, the cover device can detect (eg, via a sensor) engagement with the liquid delivery device and initiate operation of the electric drive system after detecting the liquid delivery device.

[0138] Operation 408 may optionally include driving the sensor holder in a plurality of directions. For example, the motorized drive system may drive the sensor holder in one or more back-and-forth movements to obtain a plurality of measurements at one or more specific locations. For example, the sensor holder may be driven by the motorized drive system in directions including back-and-forth, while the liquid delivery device remains fixedly positioned relative to the cover device, and / or without additional manual intervention.

[0139] Method 400 may also include an operation 410 of assessing the output of one or more sensors, the output indicating the presence of the feature of the liquid delivery device. For example, the cap device may include a processor, and the processor is configured to assess the sensor signal (for example, indicating the change of the sensor signal of the plunger) from one or more sensors, and determine the corresponding position. In certain embodiments, operation 410 may include storing the corresponding position and comparing the corresponding position during subsequent capping events. The assessment sensor signal may include assessing position changes to determine the volume (for example, by assessing the distance traveled by the plunger) of the previous dose delivery, the volume remaining in the liquid delivery device or other characteristics of the liquid delivery device.

[0140] In certain embodiments, method 400 may include an operation 412 of outputting information related to plunger position. Information may be output and / or transmitted to one or more remote devices by a cap device. For example, operation 412 may include displaying the dosage previously delivered. Alternatively or additionally, operation 412 may include displaying the dosage information related to the total liquid volume remaining in the reservoir of the liquid transporting device, the dosage information related to the dosage quantity remaining in the reservoir of the liquid transporting device, the dosage information related to the duration remaining before the reservoir of the liquid transporting device empties, the dosage information related to the time of the previous dose (for example, the time of the operation 402 of the liquid transporting device received in the cavity), the dosage information related to the time (for example, the time of the operation 402 of the liquid transporting device received in the cavity) since the last dose, and / or the dosage information related to other information related to the liquid transporting device.

[0141] In the exemplary embodiment shown, operations 408, 410 and 412 are shown as being performed after at least one of operations 404 and 406. For example, when liquid transporting device is appropriately radially aligned relative to cover device, cover device can detect the physical characteristics (for example, plunger) of liquid transporting device. When user has inserted liquid transporting device axially but failed to rotate it to radially aligned position (for example, forget to do so, positioning misalignment etc.) (for example, at time A), cover device can wait until liquid transporting device is subsequently rotated to radially aligned position (for example, at time B), and operates to detect the state associated with liquid transporting device. In various exemplary embodiments, cover device can output information / indicator (for example, just before time B), to prompt user to move liquid transporting device to radially aligned position. For example, cover device can output information / indicator, to prompt user to move liquid transporting device to radially aligned position, even if cover device engages with liquid transporting device in misaligned position before a few minutes, hours or days, and / or if display is subsequently closed (for example, closed between time A and time B).

[0142] Alternatively, at least one of operations 408, 410 and 412 can be performed before or during at least one of operations 404 and 406. For example, when the liquid transporting device is not radially aligned, the cover device is still operable to detect the physical characteristics of the liquid transporting device, and then reruns the detection process when the liquid transporting device is rotated to the radially aligned position, thereby updating the previous detection. For example, the information related to the state of the liquid transporting device determined in the previous time (for example, the volume of liquid volume in the reservoir, dosage information, the previous delivery dosage, other information related to the liquid transporting device and its operation) can be updated. In some exemplary embodiments, the cover device can output more information and / or participate in subsequent operations, such as output information related to active insulin determination, recommended correction dosage, etc.

[0143] In some embodiments, the cover device can be operated to record the time of measurement, detection or other events related to the liquid delivery device. For example, the cover device can record the time of detecting the plunger position. In another embodiment, the cover device can record the time before, when and / or after the liquid delivery device moves to the axial and / or radial alignment position relative to the cover device.

[0144] refer to Figure 5 , 6A 6B, an exemplary method 500 for detecting engagement and / or alignment of a fluid delivery device relative to a cap device is described. The method 500 may be used to perform Figure 4 Operation 404 described in .

[0145] refer to Figure 5 , some embodiments of method 500 may include an operation 502 of detecting an axial alignment position of a liquid delivery device axially inserted into a cap device. In some embodiments, the axial alignment position may be a cavity of a cap device (or a sleeve 150 ( Figure 3 For example, the most distal wall (e.g., Figure 3 The flange wall 158 in the cover device can limit the axial insertion of the liquid delivery device and define the axial alignment position of the liquid delivery device. In other embodiments, the axial alignment position can be another position in the cavity of the cover device, such as between the farthest end of the cavity and the opposite open end (or the sleeve 150 ( Figure 3 One or more axial positions of ).

[0146] In operation 502 , detecting axial alignment of the fluid delivery device may include detecting that a cap device is axially inserted and secured to the fluid delivery device, regardless of whether the cap device is radially aligned.

[0147] In other embodiments, operation 502 may be optional, and the cap device is not operable to detect the axial position of the fluid delivery device relative to the cap device.

[0148] Method 500 may include the operation 504 of activating the cover device. In certain embodiments, when the liquid transporting device engages with the cover device and / or the liquid transporting device is arranged in a predetermined axial alignment position, the cover device automatically switches to an active or operating state from an inactive or low-power state. The engagement between the liquid transporting device and the cover device and / or the activation of the cover device based on the engagement can be used as an indicator that the liquid transporting device is in the axial alignment position. The cover device can be configured to automatically activate when the liquid transporting device is at least partially inserted into the cover device, regardless of the axial and / or radial position of the liquid transporting device. In certain embodiments, when determining that the liquid transporting device is arranged in the axial and radial alignment position, the cover device is automatically activated. Alternatively or additionally, the cover device is manually activated by the user via a user input device (e.g., a power button).

[0149] Method 500 may include providing a first feedback to indicate that the liquid transport device is in the operation 506 of the axial alignment position. For example, the first feedback can be a mechanical feedback generated by the resistance spring force from the axial position device. The axial position device can be a spring with a biasing direction opposite to the direction in which the liquid transport device is inserted, and is configured to engage a part of the liquid transport device when the liquid transport device is axially inserted into the cover device. After the liquid transport device first interacts with the axial position device (for example, contact), the liquid transport device can be further inserted to push to a certain point (for example, push to a predetermined axial alignment position) to overcome the biasing force of the axial position device. This interaction can cause mechanical feedback (for example, a sense of click) through the liquid transport device and / or the cover device, and the user holding the liquid transport device and / or the cover device by a finger can feel the feedback. The embodiment of detecting the axial position and providing feedback is described in No. 8,743,662 U.S. Patent and No. 62 / 667,085 U.S. Provisional Application, and its disclosed content is fully introduced herein with appropriate degree.

[0150] Alternatively or additionally, the first feedback may be generated in other ways. For example, the first feedback is electrically generated and output in various formats (eg, visible and / or audible formats) via a display device and / or a speaker in the cover device.

[0151] Method 500 may include an operation 508 of detecting a radial position of the fluid delivery device relative to the cap device. Fig. 6A and 6B As shown, the liquid delivery device can be arranged in a radially aligned position relative to the cover device in two steps. For example, the liquid delivery device can be axially inserted into the axially aligned position relative to the cover device ( Fig. 6A 1), and then at least partially rotated relative to the cover device ( Figure 6BStep 2 in the above). The cover device may include one or more sensors for detecting when the cover device is in a predetermined radial alignment and determining whether the liquid delivery device is in a radially aligned position relative to the cover device. In some embodiments, this detection may be performed by one or more sensors supported by a sensor bracket and configured to detect the state of the liquid delivery device, such as the position and movement of a plunger in the liquid delivery device. In other embodiments, the cover device may be provided with other sensors located at fixed positions on the cover device body and / or dedicated to radial position detection. In addition, sensors in the cover device can be used to track the radial position of the liquid delivery device. Fig. 6A and 6B Embodiments of operation 508 are further described.

[0152] Method 500 may include determining whether the fluid delivery device is in a radially aligned position at operation 510. If it is determined that the fluid delivery device is in a radially aligned position ("yes") (e.g., at one or more predetermined radially aligned positions, ranges or positions, etc.), method 500 may proceed to operation 512. Otherwise ("no"), method 500 may continue with operation 516 described below.

[0153] Method 500 may include providing a second feedback to indicate that the liquid transport device is in the radial alignment position operation 512. The second feedback can be a mechanical feedback generated by a mechanical structure provided by the liquid transport device and / or the cover device. Such mechanical structure may include mechanical latches, snap-ins and other appropriate mechanical interactions. For example, the cover device includes one or more latches formed in the sleeve, and when the liquid transport device is rotated to the radial alignment position, the one or more latches may engage with one or more corresponding protrusions formed in the liquid transport device. When the liquid transport device is rotated to the radial alignment position, the protrusion of the liquid transport device slides into the latch of the cover device. When the protrusion of the liquid transport device is embedded in (for example, snapped into) the latch of the cover device, mechanical feedback (for example, a sense of click) is generated, and the mechanical feedback passes through the cover device and / or the liquid transport device. The user who holds the liquid transport device and / or the cover device by, for example, a finger can feel the feedback. Reference hereinafter Figure 8 Exemplary configurations for generating the second feedback are further detailed and described.

[0154] Alternatively or additionally, the second feedback may include other feedback. For example, the second feedback is electronically generated and output in various formats (eg, visible and / or audible formats) via a display device and / or a speaker in the cover device.

[0155] Method 500 may include an operation 514 of presenting information indicating that the liquid delivery device is in a radially aligned position. Such information may be presented to indicate to a user that the liquid delivery device is properly engaged with the cap device (e.g., for storage, subsequent operation, etc.). The information may be output in a variety of formats. In some embodiments, a display device of the cap device may display one or more symbols (e.g., signs, text, letters, numbers, etc.) indicating that the liquid delivery device is radially aligned with the cap device. For example, Figure 6B As shown, a check mark may be displayed to confirm radial alignment of the fluid delivery device. For example, other formats for outputting information may include audible output via a speaker in the cover device or tactile output via a vibrator in the cover device.

[0156] Method 500 may include presenting information indicating radial misalignment of the fluid delivery device at operation 516. Such information may be used to help the user take steps to correct the misalignment, such as further radially rotating the fluid delivery device relative to the cap device until the information disappears or until the user identifies a second feedback indicating a radially aligned position.

[0157] In some embodiments, in operation 516, if the radial misalignment remains for more than a threshold period of time, the cap device may be configured to attempt to detect the position of the plunger. For example, when radial misalignment is determined in order to continue to detect the radial position of the cap device, the cap device may measure the position of the plunger to see if it can determine the amount of the dose or the amount of the remaining contents, even though this may not be accurate. As described herein, when it is later determined that the cap device is in a radial alignment where an accurate measurement can be obtained, this potentially inaccurate measurement can be updated.

[0158] In operation 516, the information may be presented in a variety of formats. In some embodiments, the display device of the cover device may display one or more symbols (e.g., marks, text, letters, numbers, etc.) designed to indicate the misaligned state of the fluid delivery device. For example, Fig. 6A As shown, one or two arrow marks may be displayed to indicate the steps taken to arrange the liquid delivery device in an aligned position relative to the cover device. Other formats may also be provided for outputting information, such as an audible output via a speaker in the cover device or a tactile output via a vibrator in the cover device.

[0159] Reference now Fig. 6A and 6B In some embodiments, the liquid delivery device can be inserted and arranged in the alignment position in a series of steps (e.g., two steps). In the first step (step A) ( Fig. 6A ), the liquid delivery device 200 can be at least partially axially inserted into the cap device 100 in any orientation. In the second step (step B) ( Figure 6B), the liquid delivery device 200 can be rotated until the liquid delivery device 200 is in a radially aligned position.

[0160] In step A, in some embodiments, the cap device 100 includes a structure (e.g., an axial position device 300) that provides feedback (e.g., a mechanical click) when the liquid delivery device 200 is inserted into a predetermined axial position. The predetermined axial position can be a position where the liquid delivery device 200 is fully inserted into the cap device (e.g., at least partially inserted into the cap device within the range allowed by the structure of the liquid delivery device and / or the cap device). For example, Figure 3 As shown, the sleeve 150 of the cap device 100 includes a flange wall 158, which is configured to engage with the front end 208 of the liquid delivery device 200 and limit the axial movement of the liquid delivery device 200 within the cap device 100. Feedback can confirm that the liquid delivery device 100 is in the proper axial position (e.g., fully inserted) and that the liquid delivery device is ready to be rotated to the radially aligned position in step B.

[0161] In step A, the fluid delivery device 100 may be axially inserted in any radial orientation. Unless the fluid delivery device 100 is oriented in a radially aligned position relative to the cap device prior to axial insertion, the fluid delivery device 100 that has been axially inserted into the cap device is not in a radially aligned position.

[0162] In some embodiments, when the liquid delivery device 100 is in the axial alignment position, the cap device 200 can automatically switch from the inactive or power saving state to the active or powered state. In other embodiments, the cap device 200 can be manually connected, regardless of the axial and / or radial position with the liquid delivery device 100.

[0163] In step B, the liquid delivery device 200 may be radially rotated until a radial alignment position is reached. In some embodiments, the cover device 100 includes a structure (e.g., a latch and a projection configuration) that provides feedback (e.g., a mechanical click) when the liquid delivery device 200 is in a predetermined radial position. The predetermined radial position may be an orientation of the liquid delivery device relative to the cover device that does not block the view from the sensor in the cover device, thereby facilitating the sensor to clearly detect the state of the liquid delivery device, such as the position and / or movement of the plunger of the liquid delivery device. Figure 8Shown, cover device 100 comprises one or more latches 802 that are radially arranged on the inner surface of sleeve 150, and liquid transporting device 200 comprises one or more protrusions 804 that are radially arranged outside liquid transporting device 200, and is configured to replenish the latch 802 of cover device 100.When liquid transporting device 200 inserts the axial alignment position relative to cover device 100, latch 802 and protrusion 804 are arranged to axial alignment.When latch 802 and protrusion 804 axial alignment and not radially engage, this means that liquid transporting device 200 is not radially aligned when axial alignment, and liquid transporting device 200 can be rotated until the protrusion 804 of liquid transporting device 200 embeds the latch 802 of cover device 100, thereby liquid transporting device 200 is remained on radial alignment position.

[0164] One or more features of the fluid delivery device 200 may be detected to determine that the fluid delivery device 200 is in a radially aligned position relative to the cap device 100. In some embodiments, Fig. 6A and 6B As described in , the liquid delivery device 200 has one or more windows 220 formed on the reservoir 201. In an exemplary embodiment, the liquid delivery device 200 has two windows 220 arranged on opposite sides of the reservoir 201. The window 220 can extend longitudinally along the reservoir 201, and it has opposite axial edges 222 and 224. For example, the distal edge 222 of the window 220 (or the chamfer formed at the distal edge 222) can be used as a reference feature, and the sensor in the cover device 100 should detect the reference feature to verify the radial alignment of the liquid delivery device 200 relative to the cover device 100. Fig. 6A As shown, when the fluid delivery device 200 is axially inserted, the distal edge 222 of the window 220 is not within the field of view of the sensor 142 of the cap device 100, and thus the sensor 142 generates a sensor signal indicating a misalignment between the distal edge 222 and the field of view of the sensor 142. Figure 6B As shown, when the fluid delivery device 200 is radially rotated and the distal edge 222 falls within the field of view of the sensor 142, the sensor signal generated from the sensor 142 changes (e.g., the signal decreases), which indicates that the distal edge 222 is aligned with the field of view of the sensor 142. If the fluid delivery device 200 is further rotated beyond the radial alignment position, the sensor signal from the sensor 142 will change back to a signal that is the same or similar to the signal generated when the sensor 142 is not aligned with the distal edge 222 of the window 220, as shown. Fig. 6A shown.

[0165] Figure 7It is a partial cross-sectional view of cover device 100 and liquid transporting device 200, showing the predetermined feature of liquid transporting device 200 detected by the sensor of cover device when liquid transporting device 200 engages with cover device 100 in the aligned position. In this figure, the sensor 142 of cover device 100 detects the distal edge 222 of the window 220 of liquid transporting device 20, and it represents that liquid transporting device 200 is radially aligned with respect to cover device 100. For example, the distal edge 222 of the window 220 formed in the reservoir 201 of liquid transporting device 200 is aligned with the visual field 142c of sensor 142, so that the sensor signal (for example, signal decline) generated by sensor 142 is different from the sensor signal generated by sensor 142 when other features are located in the visual field 142c of sensor 142 (for example, in reservoir 201 rather than window 220 outside).

[0166] Other types of sensors 142 can be used to detect the radial alignment of the liquid delivery device. In an exemplary embodiment, the sensor can be an infrared (IR) reflected beam sensor configured to reflect the IR beam to a position close to the surface to detect the chamfer on the distal edge 222 of the window 220 when the liquid delivery device is in an appropriate radial position. The sensor includes a transmitter and a receiver arranged on the same side relative to the reservoir. The transmitter transmits the IR beam reflected from the reflector arranged on the other side of the transmitter through the reservoir, and the receiver receives the reflected beam returned through the reservoir. The signal distortion caused by the window can indicate that the liquid delivery device is correctly aligned.

[0167] Additionally or alternatively, the sensor can be an IR end beam sensor. The transmitter of the sensor can inject an IR beam into the distal end of the liquid delivery device, and the receiver detects the energy emitted from the chamfer of the reservoir window. The receiver can use geometric filtering to distinguish the signal.

[0168] Additionally or alternatively, the sensor is arranged to utilize a window groove. For example, the transmitter of the sensor emits a penetrating beam IR signal near a tangent line of the reservoir barrel. When the liquid delivery device is in an appropriate radial alignment position, the window of the reservoir provides a groove with a predetermined width, which can provide a discernible signal.

[0169] Additionally or alternatively, the sensor is configured to scan other parts of the reservoir and / or the liquid delivery device. For example, the sensor is used to perform a half scan to detect different features that may indicate the misalignment of the liquid delivery device, such as text, marks, window frames, etc. If the misalignment feature is detected by scanning, the user may be required to rotate the liquid delivery device until the liquid delivery device is buckled into the latch position. Such rotation can be detected by an accelerometer or similar component in the cover device, and a half scan can be run again to confirm that the misalignment feature is not detected.

[0170] Additionally or alternatively, the cover device includes a flexible component that can interact with the outer surface of the reservoir of the liquid delivery device. The flexibility of the component will cause the component to change its shape according to the portion of the reservoir that interacts with the component. The flexible component can be associated with a physical switch that operates to detect different movements and / or shapes of the component relative to the reservoir of the liquid delivery device.

[0171] Additionally or alternatively, the sensor has a transmitter configured to emit an IR beam to a reservoir or other part of the liquid delivery device at a low angle. When the liquid delivery device rotates in and out of the window area, reflections will transition from plastic to glass as the surface of the liquid delivery device, or vice versa. Only the light beam reflected by the glass can reach the receiver of the sensor.

[0172] Figure 8 is a partial cross-sectional view of the cap device 100 and the fluid delivery device 200, illustrating an exemplary radial retention structure 800 for removably retaining the fluid delivery device 200 and / or generating mechanical feedback to confirm radial alignment of the fluid delivery device 200 relative to the cap device 100. Figure 3 and 8 , in some embodiments, a part of radial retaining structure 800 is arranged in sleeve 150.Radial retaining structure 800 may include one or more latches 802 formed on sleeve 150 inner surfaces.In certain embodiments, sleeve 150 has a latch 802 that provides a single radial alignment for liquid transport device 200.In other embodiments, a plurality of latches 802 may be radially arranged on sleeve 150 inner surfaces, providing a plurality of radial alignment positions for liquid transport device 200.A plurality of latches 802 may be spaced equidistantly (that is, with the same angular distance) along the circumference of sleeve 150 inner surfaces.In other embodiments, at least one of a plurality of latches 802 may be spaced with different angular distances.

[0173] The radial retaining structure 800 may also include one or more protrusions 804 formed on the liquid delivery device 200. The liquid delivery device 200 includes one or more protrusions 804, which are configured to be embedded (e.g., snapped into) the catch 802 of the cover device 100 when the liquid delivery device 200 is at least partially received in the cover device 100. The catch 802 and / or the protrusion 804 are arranged to engage with each other when the liquid delivery device 200 is in an aligned position (e.g., axially and / or radially aligned position) relative to the cover device 100.

[0174] In an exemplary embodiment, the fluid delivery device 200 includes two protrusions 804, each of which is disposed on the outer surface of the reservoir 201. For example, each protrusion 804 extends from the outer surface of the reservoir 201 near the proximal edge 224 of the window 220 and is axially aligned with the distal edge 222 of the window 220. In other embodiments, other positions of the protrusions 804 are also possible.

[0175] The size of the sleeve 150 is designed to receive the fluid delivery device 200 axially in any orientation. In some embodiments, the size of the sleeve 150 is designed to accommodate at least the reservoir 201 of the fluid delivery device 200. For example, the size of the inner diameter (ID) of the sleeve 150 is designed to be substantially the same (with appropriate clearance) or larger than the outer diameter (OD) of the reservoir 201 containing the protrusion 804. Therefore, the sleeve 150 can receive the reservoir 201 of the fluid delivery device 200 in any orientation.

[0176] The cap device 100 may include one or more ridges (or ramps) 806 formed on the inner surface of the sleeve 150. The ridges 806 provide a portion that is raised from the inner diameter (ID) of the sleeve 150 so that a detent 802 can be formed in the ridges 806. The ridges 806 allow the detent 802 to be formed in the inner surface of the sleeve 150 while leaving the inner diameter (ID) of the sleeve 150 sufficient to accommodate the outer diameter (OD) of the reservoir 201 of the fluid delivery device 200 axially inserted in an orientation where the protrusion 804 is arranged to be misaligned with the ridges 806.

[0177] When the protrusion 804 begins to engage with the ridge 806 by rotating the liquid delivery device 200 relative to the cover device 100, the ridge 806 (or the portion of the sleeve 150 including the ridge 806) and / or the protrusion 804 (or the portion of the liquid delivery device 200 including the protrusion 804) can bend, which allows the protrusion 804 to slide along the ridge 806 until the protrusion 804 enters the latch 802.

[0178] The radial retention structure 800 may also include one or more axial stops 808 that prevent the protrusion 804 from accidentally disengaging from the catch 802. The axial stop 808 may include a flange formed in the catch 802 and configured to engage the protrusion 804 and prevent the protrusion 804 from axially sliding off the catch 802 (in an axial direction opposite to the direction in which the liquid delivery device 200 is inserted into the cover device 100) without an axial force sufficient to pull the liquid delivery device 200 out of the cover device 100 (e.g., a force exceeding a predetermined threshold force value).

[0179] The cap device 100 may also include one or more axial openings 810 extending from the catch 802 to allow the protrusion 804 to axially disengage from the catch 802. The axial opening 810 is formed to extend from the catch 802 in an axial direction opposite to the direction in which the liquid delivery device 200 is inserted into the cap device 100. The axial opening 810 is configured to allow the protrusion 804 to slide out of the catch 802 when the liquid delivery device 200 is axially pulled out from the cap device 100 with a force exceeding a predetermined threshold force value. An axial stop 808 may be arranged between the catch 802 and the axial opening 810 and acts as a bump in the process from the catch 802 to the axial opening 810.

[0180] In some cases, when the liquid delivery device 200 is just oriented (or intentionally oriented) to align the protrusion 804 with the catch 802 of the sleeve 150 before being inserted into the cap device 100, the axial opening 810 can be used as an entrance for the protrusion 804 to enter the catch 802. In this case, the axial force pushing the liquid delivery device 200 can overcome the resistance from the axial stop 808, and the protrusion 804 can enter the catch 802 without rotating the liquid delivery device 200 relative to the cap device 100. When the protrusion 804 is pushed axially into the catch 802, the axial stop 808 can generate mechanical feedback (e.g., a click sound).

[0181] Reference again Fig. 6A and 6B , the display device 121 of the cover device 100 can display various information (e.g., as symbols) to indicate different states of the liquid delivery device 200 and / or the cover device 100. In some embodiments, the display interface 600 of the display device 121 provides a liquid delivery device position description 602 and a liquid delivery device position indicator 604 (including 604A, 604B, and 604C). Figure 6B As shown, the display interface 600 may further provide a battery condition 606 and a status 608 associated with the liquid delivery device, such as the volume of doses delivered by the liquid delivery device, the total volume of liquid remaining in the reservoir, the number of doses remaining in the reservoir, the duration remaining before the reservoir is emptied, the time of the previous dose (e.g., the time when the cover device was replaced on the liquid delivery device), the time since the last dose (e.g., the time since the cover device was replaced on the liquid delivery device), and / or other information related to the liquid delivery device.

[0182] For example, in a first scenario, the liquid delivery device 200 remains received in the cap device 100, and the display device 121 may display the liquid delivery device status 608 (eg, the time elapsed since the last dose ( Figure 6B 3 hours and 10 minutes have passed since the last dose).

[0183] In the second scenario, when the user removes the liquid delivery device 200 from the cap device 100, the display device 121 may change and display the liquid delivery device position description 602 to indicate that the liquid delivery device has been removed (eg, Fig. 6A ). The display device 121 may further display a first liquid delivery device position indicator and a second liquid delivery device position indicator, such as a straight arrow 604A and a curved arrow 604B, to guide the steps of engaging the liquid delivery device with the cap device in a predetermined alignment position (e.g., an axial and / or radial alignment position).

[0184] In the third scenario, when the user axially inserts the liquid delivery device 200 and continues to radially rotate the liquid delivery device 200 to a predetermined alignment position (e.g., within a predetermined time period, such as within 0.5 seconds, insert and rotate the liquid delivery device), the display device 121 can change the display interface 600 to delete the previous description 602 (e.g., "cap off pen") and the previous indicator (e.g., straight arrow 604A and curved arrow 604B), and display the third liquid delivery device position indicator, such as a check mark 604C indicating that the liquid delivery device 200 is in the predetermined alignment position. The display device 121 can further display the liquid delivery device state 608.

[0185] In the fourth scene, when the user axially inserts the liquid delivery device 200 but does not rotate it to the predetermined alignment position (for example, inserts the liquid delivery device but forgets to rotate within a predetermined time period, for example, forgets to rotate within 0.5 seconds), the display device 121 can continue to display the previous description 602 (for example, "the cover leaves the pen") and / or the first indicator and the second indicator, such as a straight arrow 604A and a curved arrow 604B, within the predetermined time period (for example, 30 seconds) passed since the liquid delivery device axially inserted. After the predetermined time period, the display device 121 can change the display interface 600 to display another description 602 (for example, "rotate the pen") instead of the previous description (for example, "the cover leaves the pen"). The display interface 600 can be further modified to remove the first indicator (for example, straight arrow) 604A and continue to display the second indicator (for example, curved arrow) 604B, thereby notifying the user that the liquid delivery device still needs to be rotated. When the user rotates the liquid delivery device to the aligned position, the description 602 (eg, "rotate pen") disappears and the second indicator (eg, curved arrow) 604B is replaced by a third indicator (eg, check mark) 604C.

[0186] Available in Fig. 9 The display scenario described above is further described in Fig. 9 is a flow chart of an exemplary method 900 for displaying information on a cover device 100. Fig. 6Aand 6B Method 900 is described. Method 900 may be performed at least in part by cap device 100. Method 900 may include determining whether a liquid delivery device is at least partially inserted into the cap device at operation 902. If it is determined that the liquid delivery device is not inserted into the cap device ("No"), method 900 proceeds to operation 904. If it is determined that the liquid delivery device is inserted into the cap device ("Yes"), method 900 continues to operation 906.

[0187] Method 900 may include an operation 904 of presenting first information indicating that the liquid delivery device has been removed. As described in the second scenario above, the first information may include a description indicating that the liquid delivery device has been removed (e.g., Fig. 6A The first information may also include a first indicator and a second indicator, for example Fig. 6A The straight arrow 604A and the curved arrow 604B in FIG. 1 are used to indicate the two steps (eg, insertion and rotation) required to engage the liquid delivery device with the cap device in a predetermined alignment position.

[0188] Method 900 may include determining whether the liquid transport device is arranged in a predetermined axial position (e.g., axial alignment position) operation 906. In some cases, determining whether the liquid transport device is arranged in a predetermined axial position may be determining whether to use the snap fit between the cap device 100 and the liquid transport device 200 to correctly buckle the cap device 100 onto the liquid transport device 200. If it is determined that the liquid transport device is not arranged in a predetermined axial position ("no"), method 900 proceeds to operation 908. Otherwise ("yes"), method 900 continues operation 910.

[0189] Method 900 may include an operation 908 of presenting second information requesting axial and radial movement of the liquid delivery device relative to the cap device. Operation 908 may be performed if the liquid delivery device has not been fully inserted into the cap device, if the liquid delivery device has not been sufficiently inserted to be in a predetermined axial position, or if the liquid delivery device is being inserted but has not yet been arranged in a predetermined axial position. The second information of operation 908 may include a description indicating that the liquid delivery device is misaligned (e.g., Fig. 6A ) and / or a first indicator showing that two steps are still required (e.g., insertion and rotation) as well as a second indicator, such as Fig. 6A 604A and curved arrow 604B in FIG.

[0190] Method 900 may include determining whether the liquid delivery device is disposed in a predetermined radial position (e.g., a radially aligned position) at operation 910. If it is determined that the liquid delivery device is not disposed in a predetermined radial position ("no"), method 900 proceeds to operation 912. Otherwise ("yes"), method 900 continues to operation 914.

[0191] Method 900 may include an operation 912 of presenting third information requesting radial movement of the liquid delivery device relative to the cover device. If the liquid delivery device has been inserted to a predetermined axial position relative to the cover device but has not yet been rotated to a predetermined radial position, operation 912 may be performed. As described in the fourth scenario above, the third information may include a description 602 (e.g., "rotate the pen") requesting the liquid delivery device to rotate and / or a second indicator 604B (e.g., a curved arrow) notifying the user to rotate the liquid delivery device relative to the cover device.

[0192] Method 900 may include an operation 914 of presenting fourth information indicating that the liquid delivery device is correctly aligned. If the liquid delivery device has been inserted into a predetermined axial position and rotated to a predetermined radial position, operation 914 may be performed. As described in the third scenario above, the fourth information represents a third identifier 604C (e.g., a confirmation check mark) confirming that the liquid delivery device 200 is in a predetermined alignment position.

[0193] In certain embodiments, cover device 100 operates to promote the dose detection that is not carried out simultaneously with dose delivery. Cover device can be configured to detect the state of liquid delivery device when liquid delivery device is appropriately radially aligned relative to cover device, such as plunger position. When user has inserted liquid delivery device axially but failed to rotate it to radially aligned position (for example, forget to do so, positioning misalignment, etc.) (for example, at time A), cover device can wait until liquid delivery device is subsequently rotated to radially aligned position (for example, at time B), and operates to detect the state associated with liquid delivery device. In various exemplary embodiments, cover device can output information / indicator (for example, just before time B), to prompt user to move liquid delivery device to radially aligned position. For example, cover device can output information / indicator, to prompt user to move liquid delivery device to radially aligned position, even if cover delivery device is engaged in misaligned position with liquid delivery device a few minutes, hours or days ago, and / or if display is closed subsequently (for example, closed between time A and time B).

[0194] Alternatively, when the liquid transport device is not radially aligned, the cover device is still operable to detect the state of the liquid transport device, and reruns the detection process when the liquid transport device rotates to the radially aligned position, thereby updating the previous detection. For example, the information related to the state of the liquid transport device determined at the previous time (for example, the volume of liquid in the reservoir, dosage information, the volume of the previous delivery dose, other information related to the liquid transport device and its operation) can be updated. In some exemplary embodiments, the cover device can output more information and / or participate in subsequent operations, such as output information related to active insulin determination, recommended correction dose, etc.

[0195] In certain embodiments, the cover device is operable to record the time when the liquid device is axially engaged with the cover device (for example, also referred to as misalignment time or axial alignment time), and the time when the liquid device is radially aligned relative to the cover device (for example, also referred to as alignment time or radial alignment time). The recorded time can be used to calculate and / or update the accurate determination of the state associated with the liquid delivery device. For example, the cover device is operable to measure / calculate the liquid dosage from the liquid delivery device, and record the time (for example, misalignment time) when the liquid delivery device is only axially inserted into the cover device but is not rotated to a predetermined radial position relative to the cover device. The cover device is operable to identify the time (for example, alignment time) when the liquid delivery device moves to the predetermined alignment with the cover device, and further operate to measure / calculate the liquid dosage delivered from the liquid delivery device at the previous time, and provide updated, accurate dosage information. Such features can help to track and output accurate information associated with the liquid delivery device over a period of time.

[0196] For example, in some cases, after axial alignment is achieved at time X, even though radial misalignment exists (e.g., Figure 5 516 in the operation), the user may neglect to place the cap device 100 and the liquid delivery device 200 in a predetermined radial alignment. If the user subsequently removes the cap device 100 from the liquid delivery device 200 (e.g., for a subsequent liquid injection) before the cap device 100 and the liquid delivery device 200 are not in the predetermined radial alignment, and then replaces the cap device 100 to the liquid delivery device 200 at a predetermined axial and radial alignment at time Y, the methods, systems, and devices provided herein can determine an approximate value of each amount of liquid remaining in the liquid delivery device 200 at time X and Y. In some cases, if the cap device 100 performs a state detection operation (e.g., one or more of operations 408, 410, and 412) after the time X when the cap device 100 and the liquid delivery device 200 are out of the predetermined radial alignment, a potentially inaccurate estimate of the amount of liquid remaining can be used within time X. If state detection operations (e.g., operations 408, 410, and 412) are not used between time X and Y, or if no approximation can be derived, the methods, systems, and devices may determine the position of the plunger at time Y and infer the position of the plunger at time X based on the user's glycemic response at times before and after time X and Y, based on the user's historical doses at time X and time Y, based on the user's treatment parameters, or any other information that may approximate the dose. In some cases, the methods, systems, and devices provided herein may query the user for the amount of the dose at time X.

[0197] Although this specification contains many specific implementation details, these details should not be interpreted as limitations on any invention or the scope that may be claimed, but should be interpreted as descriptions of features specific to specific embodiments of specific inventions. Certain features described in the context of separate embodiments in this specification may also be implemented in combination in a single embodiment. Conversely, the various features described in the context of a single embodiment may also be implemented individually in multiple embodiments or in any suitable sub-combination. In addition, although features may be described above as working in certain combinations and even initially claimed to be so, one or more features of the combination may be removed from the claimed combination in some cases, and the claimed combination may be directed to a sub-combination or a variant of the sub-combination.

[0198] Similarly, although operations are depicted in a particular order in the accompanying drawings, this should not be understood as requiring that such operations be performed in the particular order shown or in a sequential order, or that all of the operations shown be performed to achieve the desired results. In some cases, multitasking and parallel processing may be advantageous. In addition, the separation of the various system components in the embodiments described above should not be understood as requiring such separation in all embodiments, but it should be understood that the described program components and systems can generally be integrated together in a single software product or packaged into multiple software products.

[0199] Thus, specific embodiments of the subject matter have been described. Other embodiments are within the scope of the appended claims. In some cases, the actions cited in the claims can be performed in different orders and still achieve the desired results. In addition, the processes depicted in the accompanying drawings do not necessarily require the specific order shown or in a sequential order to achieve the desired results. In certain embodiments, multitasking and parallel processing may be advantageous.

Claims

1. A cover device for a liquid delivery device, characterized in that: The cover device comprises: a body defining a cavity configured to at least partially receive a fluid delivery device; and A first sensor is configured to output a sensor signal indicative of a radially aligned position of the fluid delivery device relative to the body when the fluid delivery device is at least partially received within the cavity of the body.

2. The cover device according to claim 1, characterized in that The cover device further comprises: a second sensor configured to output a sensor signal indicative of a plunger of the fluid delivery device; and A processor configured to: determining that the fluid delivery device is not in the radially aligned position at a first time; determining that the fluid delivery device is in the radially aligned position at a second time later than the first time; determining a position of the plunger at the second time using the second sensor; and Based at least in part on the position of the plunger at the second time, an approximate position of the plunger at the first time is calculated.

3. The cover device according to claim 2, characterized in that The approximate position of the plunger at the first time is also based on at least one of a user's glycemic response, a user's historical dosing, and a user's therapeutic parameters.

4. The cover device according to any one of claims 1 to 3, characterized in that: The cap device further comprises a processor configured to detect the radially aligned position of the liquid delivery device based on a sensor signal of the first sensor, and A sensor bracket is movable between a first position and a second position within the cavity when the fluid delivery device is in a fixed position relative to the cavity.

5. The cover device according to claim 1, characterized in that The first sensor is configured to output a sensor signal indicative of a radial alignment position when the first sensor is located at a predetermined axial position along the fluid delivery device.

6. The cover device according to claim 4, characterized in that The first sensor is located on the sensor bracket.

7. The cover device according to any one of claims 4 to 6, characterized in that: The cover device also includes a second sensor located on the sensor bracket.

8. The cover device according to claim 7, characterized in that The second sensor is configured to output a sensor signal indicative of a plunger of the liquid delivery device during movement of the sensor bracket between the first position and the second position, and / or The cover device further comprises a motor configured to move the sensor bracket between the first position and the second position, wherein the sensor bracket mounts the first sensor, and wherein the motor operates to move the sensor bracket to a predetermined axial position, wherein the first sensor is arranged to detect a radially aligned position of the liquid delivery device, and / or wherein the processor is configured to determine a state associated with the liquid delivery device based on the sensor signal of the first sensor and the sensor signal of the second sensor, wherein the state associated with the liquid delivery device comprises at least one of: a dose volume delivered by the liquid delivery device, a total volume of liquid remaining in the liquid delivery device, a number of doses remaining in the liquid delivery device, a duration remaining before the liquid delivery device is emptied, and a time of a previous dose, a time elapsed since a previous dose, and / or The processor is configured to record a first time when the liquid delivery device is axially received in the cavity of the body and a second time when the liquid delivery device is moved to the radially aligned position, and determine a state associated with the liquid delivery device based on the sensor signal of the first sensor, the sensor signal of the second sensor, the first time, and the second time, and / or The second sensor includes a second light emitter and a second light receiver defining an optical path therebetween, wherein the second sensor is operative to detect the physical characteristic of the fluid delivery device by outputting a sensor signal indicative of the physical characteristic.

9. The cover device according to claim 4, characterized in that the first sensor comprising a first light emitter and a first light receiver with a defined light path between the first light emitter and the first light receiver, wherein the first sensor is operative to detect the physical characteristic of the fluid delivery device by outputting a sensor signal indicative of the physical characteristic, The cover device further comprises a position sensor configured to detect an axial position of the sensor bracket within the body, The physical feature of the fluid delivery device includes a plunger of the fluid delivery device, and wherein the processor is operative to detect the plunger of the fluid delivery device based on a change in the sensor signal and to determine a corresponding position of the plunger based on the sensor signal output by the position sensor.

10. The cover device according to any one of claims 1 to 9, characterized in that: The cover device further comprises: An axial position device is configured to engage the fluid delivery device axially inserted into the cavity of the body and generate a first mechanical feedback when the fluid delivery device engages the axial position device.

11. The cover device according to claim 10, characterized in that The axial position device includes a sensor configured to generate a sensor signal indicative of engagement of the fluid delivery device with the axial position device.

12. The cover device according to any one of claims 1 to 11, characterized in that The body is configured to axially receive at least a portion of the fluid delivery device within the cavity, and the fluid delivery device is at least partially rotatable relative to the body while at least a portion of the fluid delivery device is within the cavity.

13. The cover device according to claim 4, characterized in that The cap device further includes a sleeve configured to receive at least a portion of the fluid delivery device, wherein the sensor bracket is configured to move along an outer side of the sleeve.

14. The cover device according to any one of claims 1 to 13, characterized in that The first sensor is fixedly mounted on the main body.

15. A method for operating a cover device of a liquid delivery device, characterized in that: The method comprises: detecting a radial position of the liquid delivery device relative to a body of the cover device while the liquid delivery device is at least partially within the cover device; and Information related to the radial position of the fluid delivery device is output.

16. The method according to claim 15, characterized in that The method further comprises: Prior to detecting the radial position, detecting engagement of the liquid delivery device with the cover device, the liquid delivery device being rotatable relative to a body of the cover device, and activating the cover means when the liquid delivery means moves to a predetermined axial alignment position, and / or The information indicates whether the radial position of the liquid delivery device is moved to the predetermined radial alignment position, The method further comprises: generating a second mechanical feedback when the radial position of the fluid delivery device moves to the predetermined radial alignment position, detecting a first time that the fluid delivery device is axially engaged within the cavity of the body; detecting a second time when the liquid delivery device is in the predetermined radial alignment position; detecting a characteristic associated with the fluid delivery device using a sensor; and determining a state associated with the fluid delivery device based on the characteristic, the first time, and the second time, and / or The method further comprises: A first mechanical feedback is generated when the fluid delivery device moves to a predetermined axial alignment position.

17. The method according to claim 15, characterized in that The method further comprises: determining that the liquid delivery device is not radially aligned with the body of the cap device at a first time; determining that the liquid delivery device is radially aligned with the body of the cap device at a second time later than the first time; determining a position of the plunger at the second time; and calculating an approximate position of the plunger at the first time based at least in part on the position of the plunger at the second time, Wherein the approximate position of the plunger at the first time is further based on at least one of a user's glycemic response, a user's historical dosage, and a user's treatment parameter.

18. The method according to any one of claims 15 to 17, characterized in that: Detecting the radial position of a liquid delivery device includes: receiving a sensor signal from a first sensor indicative of a radially aligned position of the liquid delivery device relative to a body of the cap device, The method further comprises: A sensor carrier including the first sensor is driven to a predetermined axial position within the cover device, wherein the first sensor is configured to generate a sensor signal indicative of the radial alignment position when the sensor carrier is arranged at the predetermined axial position.

19. The method according to claim 18, characterized in that The method further comprises: driving a sensor bracket including a second sensor between a first position and a second position within the body of the cap device when detecting the radial position of the liquid delivery device; and detecting a physical characteristic of the fluid delivery device while the sensor holder moves between the first position and the second position, Wherein, detecting the physical characteristics of the liquid delivery device includes: A sensor signal indicative of a plunger of the fluid delivery device is received from the second sensor during movement of the sensor bracket between the first position and the second position.

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