Maduramicin purification reaction device

Abstract

The invention relates to the technical field of maduramicin production, in particular to a maduramicin purification reaction device which comprises a bottom plate, a control panel is mounted on the right side surface of the bottom plate, a reaction cylinder is mounted on the top surface of the bottom plate, a feeding frame is mounted on the top surface of the reaction cylinder, and a mounting frame is mounted at the middle end in the feeding frame. A first conveying inclined plate is mounted on one side of the inner wall of the feeding frame, and a second conveying inclined plate is mounted on the other side of the inner wall of the feeding frame; and the first motor is mounted in the mounting frame. According to the device disclosed by the invention, a rotating shaft can drive rotating fan blades to rotate, and then the rotating fan blades can disperse an ammonia water solution conveyed from a first conveying inclined plate and a second conveying inclined plate in the rotating process, so that the ammonia water is uniformly conveyed into the reaction cylinder, and the overall conveying effect is relatively good; according to the design, ammonia water can be intermittently conveyed, and meanwhile the conveyed ammonia water is dispersed.

Description

Technical Field

[0001] The invention relates to the technical field of maduramicin production, in particular to a maduramicin purification reaction device. Background Art

[0002] Maduramicin is a white crystalline powder with a special odor. Its pharmacological action is that of a monosaccharide ion carrier antibiotic. It is a relatively new type of polyether monovalent monosaccharide ion carrier antibiotic. This product has a broad spectrum of anticoccidial activity against both sporozoites and first-generation schizonts. This product can effectively control six common chicken coccidia and has a good preventive effect on duck coccidiosis. Maduramicin ammonium is a polyether ion carrier antibiotic produced by Maduramicin actinomycetes. Due to its unique ion carrier mechanism of action, it can specifically kill and inhibit coccidia, a parasite that is extremely harmful to animal husbandry. In practical applications, maduramicin ammonium is mainly used as an anticoccidial drug and is widely used in animal husbandry.

[0003] In this regard, China's patent application number: CN106008625B discloses a method for preparing maduramicin ammonium using maduramicin fermentation broth, and the process steps are: first pre-treating the maduramicin fermentation broth, then extracting with an organic solvent A, filtering, diluting the obtained maduramicin filtrate with an organic solvent B, and then adsorbing and desorbing with a macroporous resin, extracting the obtained desorbed liquid with an ammonia solution, nanofiltration and freeze-drying to obtain maduramicin ammonium. The method of the present invention realizes the effective separation and purification of maduramicin in the fermentation broth, effectively improves the yield of maduramicin ammonium, and its total extraction yield reaches more than 85%. The product quality meets the quality standards of the Chinese Veterinary Pharmacopoeia. At the same time, the present invention has a simple process, a short production cycle, low production cost, and the difficulty of subsequent process treatment is also effectively reduced, which is conducive to improving the international market competitiveness of maduramicin ammonium.

[0004] However, in the process of purification and extraction, the ammonia raw material needs to be added to the filtrate. Currently, most of the ammonia raw materials are directly and uniformly transported. The overall transportation efficiency is too fast, resulting in uneven mixing of the two solutions during subsequent stirring, and the overall stirring effect is incomplete. Therefore, it has become an urgent problem to be solved to improve and perfect the above problems. Summary of the invention

[0005] The object of the present invention is to provide a maduramicin purification reaction device to solve the problem that in the process of purification and extraction, an ammonia water raw material needs to be added to the filtrate. In the prior art, most of the ammonia water raw materials are directly and uniformly transported during the addition, and the overall transportation efficiency is too fast, resulting in uneven mixing of the two solutions during subsequent stirring, and the overall stirring effect is incomplete.

[0006] To achieve the above object, the present invention provides the following technical solution: a maduramicin purification reaction device, comprising a bottom plate, a control panel is installed on the right surface of the bottom plate, a reaction cylinder is installed on the top surface of the bottom plate, a feeding rack is installed on the top surface of the reaction cylinder, a mounting rack is installed at the inner middle end of the feeding rack, a first conveying inclined plate is installed on one side of the inner wall of the feeding rack, and a second conveying inclined plate is installed on the other side of the inner wall of the feeding rack;

[0007] A first motor, wherein the first motor is installed inside the mounting frame, a rotating shaft is installed at the output end of the first motor, a first bevel gear is arranged on the outer surface of the rotating shaft, a second bevel gear is meshedly connected to the front surface of the first bevel gear, a third bevel gear is meshedly connected to the back surface of the first bevel gear, a rotating column is installed on the front surface of the second bevel gear, and a rotating disk is installed at one end of the rotating column away from the second bevel gear.

[0008] Preferably, a boss is installed on the front surface of the rotating disk, and a reciprocating disk is arranged on the outer surface of the boss.

[0009] Preferably, a reciprocating plate is installed at the lower end of the reciprocating disc, and a blocking plate is installed at the lower end of the reciprocating plate.

[0010] Preferably, a limiting frame is provided on the outer surface of the reciprocating plate, and the back side of the limiting frame is mounted on the front surface of the mounting frame.

[0011] Preferably, the lower end of the rotating shaft passes through the inner bottom wall of the mounting frame and is equipped with a rotating fan blade, and the back side of the reaction cylinder is equipped with a second motor.

[0012] Preferably, an output shaft is fixedly connected to the front surface of the second motor, a connecting sleeve is installed on the outer surface of the output shaft, and a first stirring ring is installed on the left surface of the connecting sleeve.

[0013] Preferably, an adapting net is provided inside the first stirring ring, a groove is provided on the surface of the first stirring ring, and a slot is provided on the inner side wall of the first stirring ring.

[0014] Preferably, an inserting column is provided inside the slot, a flow net is installed on the front surface of the inserting column, and the flow net and the groove are adapted to each other.

[0015] Preferably, a first stirring block and a second stirring ring are sequentially installed on the right side surface of the output shaft from front to back, and the second stirring ring has the same structure as the first stirring ring.

[0016] Preferably, a second stirring block is disposed on the left side surface of the output shaft, and inclined grooves are disposed inside the second stirring block and the first stirring block.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. The maduramicin purification reaction device is provided with a feeding rack, a mounting rack, a first conveying ramp, a second conveying ramp, a first motor, a rotating shaft, a first bevel gear, a second bevel gear, a third bevel gear, a rotating column, a rotating disk, a convex column, a reciprocating disk, a reciprocating plate, a blocking plate, a limiting rack and a rotating fan blade. When in use, first, the interior of the bottom plate will have a filtrate adsorbed and analyzed by a macroporous resin, and then the ammonia solution is transported from the surface of the first conveying ramp and the second conveying ramp to the interior of the reaction cylinder. When the ammonia solution is transported through the first conveying ramp and the second conveying ramp, the first motor is started at this time, and the rotating shaft is driven to rotate by the first motor, and then the rotating shaft also drives the first bevel gear to rotate, and then the first bevel gear is respectively meshed with the second bevel gear and the third bevel gear, so that the second bevel gear and the third bevel gear can both rotate, and then the second bevel gear drives the rotating column to rotate, and the rotating column drives the rotating disk to rotate. When the rotating disk rotates, the convex column rotates, and then the convex column will drive the reciprocating disk and the reciprocating plate to move up and down, so that the reciprocating plate will also drive the blocking plate to move downward, and then the blocking plate will hit the inner wall of the first conveying inclined plate. When the blocking plate hits the inner wall of the first conveying inclined plate, the ammonia solution is blocked by the blocking plate, so that the ammonia solution on the surface of the first conveying inclined plate can be intermittently transported, thereby avoiding the one-time transport of the ammonia solution, so that the second conveying inclined plate can also complete the same operation, and can intermittently transport the ammonia solution. At the same time, the rotating shaft will drive the rotating fan blades to rotate, and then the rotating fan blades can disperse the ammonia solution transported from the first conveying inclined plate and the second conveying inclined plate during the rotation process, so that the ammonia solution is evenly transported to the inside of the reaction cylinder, and the overall transportation effect is good. This design can transport the ammonia solution intermittently and disperse the transported ammonia solution after transportation, which reflects the functionality of the design.

[0019] 2. The maduramicin purification reaction device is provided with a second motor, an output shaft, a connecting sleeve, a first stirring ring, an adaptor net, a groove, a slot, a plug, a circulation net, a second stirring ring, a first stirring block, a second stirring block and an inclined slot. When in use, the second motor is first started, and the output shaft is driven to rotate by the second motor, and then the connecting sleeve is driven to rotate by the output shaft, and then the connecting sleeve and the first stirring ring are driven to rotate by the output shaft, and the second stirring ring is also rotated, and then the mixed solution can be circulated by the design of the adaptor net, and the overall circulation effect is good. At the same time, a circulation net is installed inside the groove, and the mixed solution can also be circulated through the circulation net, so that the first stirring ring passes through when rotating. The design of the adapter net and the circulation net makes the circulation effect of the mixed solution better, and the first stirring ring can also drive the mixed solution inside the reaction tube to stir. Similarly, the second stirring ring can also complete the same stirring operation, and the output shaft will also drive the first stirring block and the second stirring block to rotate. When the first stirring block and the second stirring block rotate, the inclined design of the inclined groove makes the circulation rate of the mixed solution faster. The rotation of the output shaft can accelerate the stirring speed of the mixed solution inside the reaction tube. At the same time, the circulation speed of the mixed solution is faster during stirring. The circulation net can be disassembled and installed. The circulation net can be installed inside the groove by pressing the plug against the inside of the slot, which reflects the ingenuity of the design. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a three-dimensional schematic diagram of the structure of the present invention;

[0021] Figure 2 It is a three-dimensional schematic diagram of the feeding rack and the rotating fan blade structure of the present invention;

[0022] Figure 3 It is a three-dimensional schematic diagram of the first motor and the rotating fan blade structure of the present invention;

[0023] Figure 4 It is a three-dimensional schematic diagram of the rotating disk and the blocking plate structure of the present invention;

[0024] Figure 5 is a cross-sectional schematic diagram of the bottom plate structure of the present invention;

[0025] Figure 6 It is a three-dimensional schematic diagram of the first stirring ring and the output shaft structure of the present invention;

[0026] Figure 7 It is a schematic diagram of the disassembly of the first stirring ring and the circulation network structure of the present invention;

[0027] Figure 8 It is a schematic diagram of the disassembly of the mounting frame and the first conveying inclined plate structure of the present invention.

[0028] In the figure: 1, bottom plate; 2, control panel; 3, reaction cylinder; 4, feeding rack; 5, mounting rack; 6, first conveying inclined plate; 7, second conveying inclined plate; 8, first motor; 9, rotating shaft; 10, first bevel gear; 11, second bevel gear; 12, third bevel gear; 13, rotating column; 14, rotating disk; 15, convex column; 16, reciprocating disk; 17, reciprocating plate; 18, blocking plate; 19, limiting rack; 20, rotating fan blade; 21, second motor; 22, output shaft; 23, connecting sleeve; 24, first stirring ring; 25, adapter net; 26, groove; 27, slot; 28, plug column; 29, circulation net; 30, second stirring ring; 31, first stirring block; 32, second stirring block; 33, inclined slot. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] See also Figure 1-Figure 8 , an embodiment provided by the present invention:

[0031] A maduramicin purification reaction device, the control panel 2, the first motor 8, the reciprocating disk 16, the rotating fan blade 20, the second motor 21, the circulation net 29, the second stirring ring 30 and the chute 33 used in the present application are all products that can be directly purchased on the market, and their principles and connection methods are all prior arts well known to those skilled in the art, so they will not be repeated here, comprising a bottom plate 1, the right side surface of the bottom plate 1 is equipped with a control panel 2, the top surface of the bottom plate 1 is equipped with a reaction tube 3, the top surface of the reaction tube 3 is equipped with a feeding rack 4, and the reaction tube 3 The right side surface of the feeding frame 4 is provided with a discharge pipe, the outer surface of the discharge pipe is provided with a solenoid valve, the inner middle end of the feeding frame 4 is provided with a mounting frame 5, the inner wall side of the feeding frame 4 is provided with a first conveying inclined plate 6, and the inner wall side of the feeding frame 4 is provided with a second conveying inclined plate 7. First, the second motor 21 is started, and the output shaft 22 is driven to rotate by the second motor 21, and then the connecting sleeve 23 is driven to rotate by the output shaft 22, and then the connecting sleeve 23 and the first stirring ring 24 are driven to rotate by the output shaft 22, and the second stirring ring 30 is also driven to rotate. The first stirring ring 24 rotates, and then the design of the adapter net 25 enables the mixed solution to circulate, and the overall circulation effect is good. At the same time, a circulation net 29 is installed inside the groove 26, and the mixed solution can also be circulated through the circulation net 29. Therefore, when the first stirring ring 24 rotates, the design of the adapter net 25 and the circulation net 29 makes the mixed solution circulate better, and the first stirring ring 24 can also drive the mixed solution inside the reaction tube 3 to stir. Similarly, the second stirring ring 30 can also complete the same stirring operation, and the output shaft 22 will also drive the first stirring block 31 and the second stirring block 32 to rotate. When the first stirring block 31 and the second stirring block 32 rotate, the inclined design of the inclined groove 33 makes the mixed solution flow faster. The rotation of the output shaft 22 can accelerate the stirring speed of the mixed solution inside the reaction tube 3. At the same time, the mixed solution circulates faster when stirring. It can be disassembled and installed through the circulation net 29, and the plug 28 can be pressed against the inside of the slot 27, so that the circulation net 29 can be installed to the inside of the groove 26;

[0032] The first motor 8 is installed inside the mounting frame 5, a rotating shaft 9 is installed at the output end of the first motor 8, a first bevel gear 10 is arranged on the outer surface of the rotating shaft 9, a second bevel gear 11 is meshedly connected to the front surface of the first bevel gear 10, a third bevel gear 12 is meshedly connected to the back surface of the first bevel gear 10, a rotating column 13 is installed on the front surface of the second bevel gear 11, a rotating disk 14 is installed on the end of the rotating column 13 away from the second bevel gear 11, a boss 15 is installed on the front surface of the rotating disk 14, a reciprocating disk 16 is arranged on the outer surface of the boss 15, a reciprocating plate 17 is installed on the lower end of the reciprocating plate 17, a blocking plate 18 is installed on the lower end of the reciprocating plate 17, a limiting frame 19 is arranged on the outer surface of the reciprocating plate 17, and a limiting frame 19 is arranged on the back side of the limiting frame 19. It is mounted on the front surface of the mounting frame 5, the lower end of the rotating shaft 9 passes through the inner bottom wall of the mounting frame 5 and is equipped with a rotating fan blade 20, the back of the reaction tube 3 is equipped with a second motor 21, the front surface of the second motor 21 is fixedly connected with an output shaft 22, the outer surface of the output shaft 22 is equipped with a connecting sleeve 23, the left surface of the connecting sleeve 23 is equipped with a first stirring ring 24, the interior of the first stirring ring 24 is provided with an adaptor net 25, the surface of the first stirring ring 24 is provided with a groove 26, the inner side wall of the first stirring ring 24 is provided with a slot 27, the interior of the slot 27 is provided with a plug 28, the front surface of the plug 28 is equipped with a circulation net 29, the circulation net 29 and the groove 26 are adapted to each other, and the right side surface of the output shaft 22 is sequentially equipped with first stirring blocks 31 from front to back. The second stirring ring 30 has the same structure as the first stirring ring 24. The left side surface of the output shaft 22 is provided with a second stirring block 32. The second stirring block 32 and the first stirring block 31 are both provided with an inclined groove 33. First, the interior of the bottom plate 1 will have a filtrate that has been adsorbed and analyzed by the macroporous resin, and then the ammonia solution is transported from the surface of the first conveying inclined plate 6 and the second conveying inclined plate 7 to the interior of the reaction cylinder 3. When the ammonia solution is transported through the first conveying inclined plate 6 and the second conveying inclined plate 7, the first motor 8 is started at this time, and the rotating shaft 9 is driven to rotate by the first motor 8, and then the rotating shaft 9 will also drive the first bevel gear 10 to rotate, and then the first bevel gear 10 is respectively connected to the second bevel gear 11 and the third bevel gear 12 through the first bevel gear 10. 12 are meshed, so that the second bevel gear 11 and the third bevel gear 12 can both rotate, and then the second bevel gear 11 drives the rotating column 13 to rotate, and the rotating column 13 drives the rotating disk 14 to rotate. When the rotating disk 14 rotates, the boss 15 rotates, and then the boss 15 drives the reciprocating disk 16 and the reciprocating plate 17 to move up and down, so that the reciprocating plate 17 also drives the blocking plate 18 to move downward, and then the blocking plate 18 will abut against the inner wall of the first conveying inclined plate 6. When the blocking plate 18 abuts against the inner wall of the first conveying inclined plate 6, the ammonia solution is blocked by the blocking plate 18, so that the ammonia solution on the surface of the first conveying inclined plate 6 can be intermittently transported, thereby avoiding the one-time transportation of the ammonia solution.Therefore, the second conveying inclined plate 7 can also perform the same operation, and can intermittently convey the ammonia solution. At the same time, the rotating shaft 9 will drive the rotating blades 20 to rotate. Then, the rotating blades 20 can disperse the ammonia solution conveyed from the first conveying inclined plate 6 and the second conveying inclined plate 7 during the rotation process, so that the ammonia solution is evenly conveyed to the inside of the reaction cylinder 3. The overall conveying effect is good. This design can intermittently convey the ammonia solution and disperse the conveyed ammonia solution after conveying.

[0033] Working principle: When the staff uses the device, firstly, the device is connected to an external power supply to provide power support for the device. Firstly, the inside of the bottom plate 1 will have the filtrate adsorbed and analyzed by the macroporous resin, and then the ammonia solution is transported from the surface of the first conveying inclined plate 6 and the second conveying inclined plate 7 to the inside of the reaction cylinder 3. When the ammonia solution is transported through the first conveying inclined plate 6 and the second conveying inclined plate 7, the first motor 8 is started at this time, and the rotating shaft 9 is driven to rotate by the first motor 8, and then the rotating shaft 9 will also drive the first bevel gear 10 to rotate, and then the first bevel gear 10 is respectively engaged with the second bevel gear 11 and the third bevel gear 12, so that the second bevel gear 11 and the third bevel gear 12 can both rotate, and then The second bevel gear 11 drives the rotating column 13 to rotate, and the rotating column 13 drives the rotating disk 14 to rotate. When the rotating disk 14 rotates, the boss 15 rotates, and then the boss 15 drives the reciprocating disk 16 and the reciprocating plate 17 to move up and down, so that the reciprocating plate 17 also drives the blocking plate 18 to move downward, and then the blocking plate 18 will abut against the inner wall of the first conveying inclined plate 6. When the blocking plate 18 abuts against the inner wall of the first conveying inclined plate 6, the ammonia solution is blocked by the blocking plate 18, so that the ammonia solution on the surface of the first conveying inclined plate 6 can be intermittently transported, thereby avoiding the one-time transportation of the ammonia solution, so that the second conveying inclined plate 7 can also complete the same operation, and can intermittently transport the ammonia solution The rotating shaft 9 drives the rotating blades 20 to rotate, and then the rotating blades 20 can disperse the ammonia solution delivered from the first delivery inclined plate 6 and the second delivery inclined plate 7 during the rotation process, so that the ammonia solution is evenly delivered to the interior of the reaction cylinder 3, and the output shaft 22 is driven to rotate by the second motor 21, and then the connecting sleeve 23 is driven to rotate by the output shaft 22, and then the connecting sleeve 23 and the first stirring ring 24 are driven to rotate by the output shaft 22, and the second stirring ring 30 is also rotated, and then the mixed solution can be circulated by the design of the adapter net 25, and the inner part of the groove 26 is provided with a circulation net 29, and the mixed solution can also be circulated through the circulation net 29, so that the first stirring ring 24 is driven to rotate by the output shaft 22. When the mixing ring 24 rotates, the design of the adapter net 25 and the circulation net 29 makes the mixed solution flow better, and the first stirring ring 24 can also drive the mixed solution inside the reaction tube 3 to stir. Similarly, the second stirring ring 30 can also complete the same stirring operation, and the output shaft 22 will also drive the first stirring block 31 and the second stirring block 32 to rotate. When the first stirring block 31 and the second stirring block 32 rotate, the inclined design of the inclined groove 33 makes the mixed solution flow faster. The rotation of the output shaft 22 can accelerate the stirring speed of the mixed solution inside the reaction tube 3. It can be disassembled and installed through the circulation net 29 by pressing the plug 28 against the inside of the slot 27. The above is all the working principles of the present invention.

[0034] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any ordinary technician in the industry can smoothly implement the present invention as shown in the drawings and described above. However, any equivalent changes, modifications and evolutions made by technicians familiar with the profession without departing from the scope of the technical solution of the present invention using the technical content disclosed above are all equivalent embodiments of the present invention. At the same time, any equivalent changes, modifications and evolutions made to the above embodiments based on the essential technology of the present invention are still within the protection scope of the technical solution of the present invention.

Claims

1. A maduramicin purification reaction device, comprising a bottom plate (1), a control panel (2) being mounted on the right side surface of the bottom plate (1), and a reaction cylinder (3) being mounted on the top surface of the bottom plate (1), characterized in that: A feeding rack (4) is installed on the top surface of the reaction cylinder (3), a mounting rack (5) is installed at the inner middle end of the feeding rack (4), a first conveying inclined plate (6) is installed on one side of the inner wall of the feeding rack (4), and a second conveying inclined plate (7) is installed on the other side of the inner wall of the feeding rack (4); A first motor (8), the first motor (8) is mounted inside the mounting frame (5), a rotating shaft (9) is mounted on the output end of the first motor (8), a first bevel gear (10) is arranged on the outer surface of the rotating shaft (9), a second bevel gear (11) is meshedly connected to the front surface of the first bevel gear (10), a third bevel gear (12) is meshedly connected to the back surface of the first bevel gear (10), a rotating column (13) is mounted on the front surface of the second bevel gear (11), and a rotating disk (14) is mounted on one end of the rotating column (13) away from the second bevel gear (11).

2. A maduramicin purification reaction device according to claim 1, characterized in that: A convex column (15) is installed on the front surface of the rotating disk (14), and a reciprocating disk (16) is arranged on the outer surface of the convex column (15).

3. A maduramicin purification reaction device according to claim 2, characterized in that: A reciprocating plate (17) is installed at the lower end of the reciprocating disc (16), and a blocking plate (18) is installed at the lower end of the reciprocating plate (17).

4. A maduramicin purification reaction device according to claim 3, characterized in that: A limiting frame (19) is provided on the outer surface of the reciprocating plate (17), and the back surface of the limiting frame (19) is mounted on the front surface of the mounting frame (5).

5. The maduramicin purification reaction device according to claim 1, characterized in that: The lower end of the rotating shaft (9) passes through the inner bottom wall of the mounting frame (5) and is equipped with a rotating fan blade (20), and the back of the reaction cylinder (3) is equipped with a second motor (21).

6. A maduramicin purification reaction device according to claim 5, characterized in that: An output shaft (22) is fixedly connected to the front surface of the second motor (21), a connecting sleeve (23) is installed on the outer surface of the output shaft (22), and a first stirring ring (24) is installed on the left surface of the connecting sleeve (23).

7. A maduramicin purification reaction device according to claim 6, characterized in that: An adapting net (25) is arranged inside the first stirring ring (24), a groove (26) is provided on the surface of the first stirring ring (24), and a slot (27) is provided on the inner side wall of the first stirring ring (24).

8. A maduramicin purification reaction device according to claim 7, characterized in that: An inserting column (28) is arranged inside the slot (27), a flow net (29) is installed on the front surface of the inserting column (28), and the flow net (29) and the groove (26) are adapted to each other.

9. The maduramicin purification reaction device according to claim 6, characterized in that: A first stirring block (31) and a second stirring ring (30) are sequentially mounted on the right side surface of the output shaft (22) from front to back, and the second stirring ring (30) has the same structure as the first stirring ring (24).

10. A maduramicin purification reaction device according to claim 6, characterized in that: A second stirring block (32) is disposed on the left side surface of the output shaft (22), and inclined grooves (33) are disposed inside the second stirring block (32) and the first stirring block (31).

Images