Intelligent release type feed additive as well as preparation method and application thereof
By adopting a double-layer envelope structure in feed additives, the sustained release layer and acid-base buffer layer are used to regulate the release of nutrient particles according to the digestion process of beef cattle, the problem that traditional feed additives cannot be intelligently adjusted is solved, and the nutrition utilization rate and beef cattle are improved Growth performance improves breeding benefits.
Patent Information
- Application Number
- CN202411611253.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-12
- Publication Date
- 2025-01-10
AI Technical Summary
Traditional feed additives cannot intelligently regulate the release of nutrients according to the digestive process of beef cattle, resulting in waste of nutrients and insufficient nutrition in certain digestive stages, which cannot effectively maintain the health of beef cattle's digestive system.
Intelligent release feed additives using double-layer coatings include sustained-release layer and acid-base buffer layer. The sustained-release layer is selected from materials such as cellulose acetate phthalate, phthalate hexanine, etc. The acid-base buffer layer is sodium bicarbonate and Magnesium oxide mixture, regulates the release of nutrient particles according to the pH changes in beef cattle digestion process.
It improves the utilization rate of nutrient particles in the animal's digestive tract, improves the growth performance and health status of animals, ensures the full absorption of nutrients, reduces the waste of nutrients, and improves the feed-meat ratio and breeding benefits.
Smart Images
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Abstract
Description
Technical Field
[0001] The present application relates to the field of animal husbandry technology, and in particular to an intelligent release feed additive and a preparation method and application thereof. Background Art
[0002] The beef cattle industry faces multiple challenges such as improving digestion efficiency, accurately matching nutrition during growth stages, and maintaining a healthy digestive system. Traditional feed additives are mostly a mixture of nutrients in a fixed ratio, which cannot be intelligently adjusted according to the digestion process of beef cattle, resulting in the waste of some nutrients during the digestion process, and may also cause malnutrition of beef cattle at certain digestion stages.
[0003] In recent years, some "intelligent" feed additives have appeared on the market. Most of these feed additives only improve a single function, such as focusing on the regulation of intestinal microecology; they are unable to dynamically release nutrients according to changes in pH during the digestion of beef cattle, resulting in certain limitations on the promotion of these products in practical applications.
[0004] Therefore, the beef cattle breeding industry is in urgent need of a new type of intelligent feed additive that can respond to the acid-base environment in the stomach and intestines of beef cattle in real time, intelligently release nutrients, and effectively maintain the health of their digestive system, thereby improving the overall benefits of beef cattle breeding. Summary of the invention
[0005] In order to solve the problem that existing feed additives cannot intelligently regulate the release of nutrients according to the digestion process of beef cattle, the present application provides an intelligent release feed additive and a preparation method and application thereof.
[0006] In the first aspect, the intelligent release feed additive provided by the present application adopts the following technical solution: An intelligent release feed additive, comprising nutrient particles, and a slow-release layer and an acid-base buffer layer sequentially wrapped on the outer surface of the nutrient particles; The sustained-release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4)-2-amino-BD glucose, polymethyl methacrylate and hydroxypropyl methylcellulose phthalate; The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1:(0.17-0.36).
[0007] The present application provides an intelligent release feed additive with a double-layer coating, which can intelligently adjust the acidity and alkalinity of the environment and release nutrients according to the changes in the pH value of the digestive process of beef cattle, prevent the nutrient particles from chemically changing and failing under over-acid or over-alkaline conditions, and improve the utilization rate of the nutrient particles in the animal digestive tract, thereby improving the growth performance and health status of the animal. Among them, the acid-base buffer layer uses a specific proportion of sodium bicarbonate and magnesium oxide, which can adjust the pH value of the microenvironment after the feed additive enters the stomach and intestines of beef cattle, providing favorable conditions for the release of the feed additive. The sustained-release layer material uses a pH-sensitive release material, and the above-mentioned material can only slowly dissolve and release the internal nutrients under slightly acidic or neutral conditions, further ensuring that the internal feed additive can be gradually released under appropriate conditions, thereby ensuring that the beef cattle can fully absorb nutrients and avoid the waste of nutrients. Therefore, the double-layer coated intelligent release feed additive provided by the present application can intelligently adjust the gastrointestinal acidity and alkalinity of animals, and release nutrients under appropriate conditions, thereby ensuring the utilization rate of nutrients, improving the animal's feed-to-meat ratio, and improving growth performance and health status.
[0008] In the present application, sodium bicarbonate and magnesium oxide are used as acid-reducing buffer substances, which can play a buffering role in the rumen of beef cattle, neutralize the acidity of feed and the organic acid produced by rumen microorganisms, thereby maintaining the stability of rumen pH; thereby facilitating the digestion of cellulose and other sugars in feed, improving feed conversion rate, and improving feed-to-meat ratio; in addition, after the above-mentioned acid-reducing buffer substances stabilize the pH of the rumen at neutral, they can also release certain nutrients, improve the growth performance and health status of animals, and improve breeding efficiency.
[0009] Optionally, the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1:(0.21-0.32).
[0010] In some embodiments, the weight ratio of sodium bicarbonate to magnesium oxide can be 1:(0.17-0.21), 1:(0.17-0.27), 1:(0.17-0.32), 1:(0.17-0.36), 1:(0.21-0.27), 1:(0.21-0.32), 1:(0.21-0.36), 1:(0.27-0.32), 1:(0.27-0.36) or 1:(0.32-0.36).
[0011] In a specific embodiment, the weight ratio of sodium bicarbonate to magnesium oxide can also be 1:0.17, 1:0.21, 1:0.27, 1:0.32 or 1:0.36.
[0012] Optionally, the sustained-release layer is a mixture of cellulose acetate phthalate and tetrandrine.
[0013] Optionally, the weight ratio of the cellulose acetate phthalate to tetrandrine is 1:(0.1-0.5).
[0014] In the present application, it was found through experimental research that further using a mixture of cellulose acetate phthalate and tetrandrine as a sustained-release material and controlling the weight ratio of the two within the above range can enable beef cattle to absorb nutrients more fully and improve the production performance of beef cattle.
[0015] Optionally, the weight ratio of the cellulose acetate phthalate to tetrandrine is 1:(0.2-0.4).
[0016] In some embodiments, the weight ratio of cellulose acetate phthalate and tetrandrine can be 1:(0.1-0.2), 1:(0.1-0.3), 1:(0.1-0.4), 1:(0.1-0.5), 1:(0.2-0.3), 1:(0.2-0.4), 1:(0.2-0.5), 1:(0.3-0.4), 1:(0.3-0.5) or 1:(0.4-0.5).
[0017] In a specific embodiment, the weight ratio of cellulose acetate phthalate to tetrandrine can also be 1:0.1, 1:0.2, 1:0.3, 1:0.4 or 1:0.5.
[0018] Optionally, the nutritional particles include the following components in parts by weight: 1-2 parts of amino acids, 1-2 parts of minerals, and 0.5-0.8 parts of vitamins.
[0019] Optionally, the weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer is 5:(0.3-1):(0.3-1).
[0020] In some embodiments, the weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer can be 5:(0.3-0.5):0.8, 5:(0.3-0.8):0.8, 5:(0.3-1):0.8, 5:(0.5-0.8):0.8, 5:(0.5-1):0.8, 5:(0.8-1):0.8, 5:0.8:(0.3-0.5), 5:0.8:(0.3-0.8), 5:0.8:(0.3-1), 5:0.8:(0.5-0.8), 5:0.8:(0.5-1) or 5:0.8:(0.8-1).
[0021] In a specific embodiment, the weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer can also be 5:0.3:0.8, 5:0.5:0.8, 5:0.8:0.8, 5:1:0.8, 5:0.8:0.3, 5:0.8:0.5 or 5:0.8:1.
[0022] In a second aspect, the present application provides a method for preparing an intelligent release feed additive.
[0023] A method for preparing an intelligent release feed additive comprises the following steps: uniformly mixing the components of nutritional granules, granulating to obtain nutritional granules; spraying the surfaces of the nutritional granules with moisture, then mixing with a sustained-release layer material, and evenly shaking so that the surfaces of the nutritional granules are completely covered with the sustained-release layer material, thereby obtaining prefabricated granules; then continuing to spray the surfaces of the prefabricated granules with moisture, and mixing with an acid-base buffer layer material, and evenly shaking so that the surfaces of the prefabricated granules are completely covered with the acid-base buffer layer material, thereby obtaining an intelligent release feed additive.
[0024] In a third aspect, the present application provides an application of an intelligent release feed additive in animal feed.
[0025] A beef cattle feed comprises the intelligent release feed additive; the weight ratio of the intelligent release feed additive to the beef cattle feed is 1.5-2.5 g / kg.
[0026] In summary, this application has the following beneficial effects: 1. The present application adopts nutrient particles, a sustained-release layer and an acid-base buffer layer to prepare an intelligent-release feed additive, which can intelligently adjust the pH changes in the stomach and intestines of beef cattle during the digestion process and release nutrients under appropriate conditions, thereby ensuring that beef cattle can fully absorb nutrients, improve feed-to-meat ratio, improve growth performance and health status, and thus increase the breeding efficiency of the farm, and has good economic value and application prospects.
[0027] 2. The present application adopts sodium bicarbonate and magnesium oxide in a weight ratio of 1:(0.17-0.36) as the acid-base buffer layer, and cellulose acetate phthalate and tetrandrine in a weight ratio of 1:(0.2-0.4) as the sustained-release layer, and controls the weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer within the range of 5:(0.3-1):(0.3-1). The prepared intelligent release feed additive has a good growth-promoting effect on beef cattle, thereby improving the growth performance of beef cattle. DETAILED DESCRIPTION
[0028] The present application provides an intelligent release feed additive, comprising nutritional particles, and a sustained-release layer and an acid-base buffer layer sequentially wrapped on the outer surface of the nutritional particles; the weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer is 5:(0.3-1):(0.3-1). The nutritional particles include the following components in parts by weight: 1-2 parts of amino acids, 1-2 parts of minerals and 0.5-0.8 parts of vitamins. The sustained-release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4)-2-amino-BD glucose, polymethyl methacrylate and hydroxypropyl methylcellulose phthalate. The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1:(0.17-0.36).
[0029] Further, the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1:(0.21-0.32). The sustained-release layer is a mixture of cellulose acetate phthalate and tetrandrine, and the weight ratio of cellulose acetate phthalate and tetrandrine is 1:(0.1-0.5). Further, the weight ratio of cellulose acetate phthalate and tetrandrine is 1:(0.2-0.4).
[0030] The preparation method of the intelligent release feed additive provided in the present application comprises the following steps: The components of the nutritional granules are mixed evenly, and the nutritional granules are obtained by granulation; the surfaces of the nutritional granules are sprayed with moisture, and then mixed with the sustained-release layer material and shaken evenly so that the surfaces of the nutritional granules are completely covered with the sustained-release layer material to obtain prefabricated granules; then the surfaces of the prefabricated granules are sprayed with moisture again, and mixed with the acid-base buffer layer material and shaken evenly so that the surfaces of the prefabricated granules are completely covered with the acid-base buffer layer material to obtain an intelligent release feed additive.
[0031] In this application, the cellulose acetate phthalate was purchased from Merck, CAS No. 9004-38-0; tetrandrine was purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.; the model of hydroxypropyl methylcellulose phthalate was HPMCP-H55, purchased from Shandong Suihua Biotechnology Co., Ltd.; sodium bicarbonate was food grade, purchased from Jiangsu Jiujia Biotechnology Co., Ltd.; magnesium oxide was feed grade, purchased from Shandong Gushuo Biotechnology Co., Ltd. The raw materials, reagents, solvents, etc. of this application can all be obtained through commercial purchase.
[0032] The present application is further described in detail below in conjunction with embodiments and performance testing experiments.
[0033] Examples 1-5 Embodiments 1-5 each provide an intelligent release feed additive.
[0034] The difference between the above embodiments is that the ratio of sodium bicarbonate and magnesium oxide in the acid-base buffer layer of the intelligent release feed additive is specifically shown in Table 1 below.
[0035] The preparation method of the intelligent release feed additive provided in Examples 1-5 comprises the following steps: (1) First, weigh 15 kg of amino acids, 15 kg of minerals and 7 kg of vitamins and mix them. Spray water in small amounts several times while stirring until the mixture can be kneaded into a ball and does not feel damp. Then pour the mixture into a granulator for extrusion granulation. After screening, obtain nutrient granules with a particle size of 5±2 mm.
[0036] Sodium bicarbonate and magnesium oxide were uniformly mixed according to the weight ratio shown in Table 1 to obtain an acid-base buffer layer material.
[0037] Cellulose acetate phthalate and tetrandrine were uniformly mixed in a weight ratio of 1:0.3 to obtain a sustained-release layer material.
[0038] (2) Take 500 g of nutrient particles, 80 g of acid-base buffer layer material and 80 g of sustained-release layer material respectively, spray the surface of the nutrient particles with water, then mix with the sustained-release layer material and shake evenly so that the surface of the nutrient particles is completely covered with the sustained-release layer material to obtain prefabricated particles; then continue to spray the surface of the prefabricated particles with water, mix with the acid-base buffer layer material and shake evenly so that the surface of the prefabricated particles is completely covered with the acid-base buffer layer material to obtain an intelligent release feed additive.
[0039] Table 1 Proportions of sodium bicarbonate and magnesium oxide in the acid-base buffer layer of Examples 1-5 Example Weight ratio of sodium bicarbonate to magnesium oxide 1 1：0.17 2 1：0.21 3 1：0.27 4 1：0.32 5 1：0.36 Embodiment 6-11 Examples 6-11 each provide an intelligent release feed additive.
[0040] The difference between the above embodiment and embodiment 3 is that the components and proportions of the sustained-release layer material of the intelligent-release feed additive are specifically shown in Table 2 below.
[0041] Table 2 Components and ratios of sustained-release layer materials of Example 3 and Examples 6-11 Examples 12-18 Examples 12-18 each provide an intelligent release feed additive.
[0042] The difference between the above embodiment and embodiment 3 is that the weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer is shown in Table 3 below. 500g nutritional particles, 80g material and 80g material Table 3 Weight ratios of the nutritional particles, the sustained-release layer and the acid-base buffer layer in Example 3 and Examples 12-18 Comparative Example 1 Comparative Example 1 provides an intelligent release feed additive.
[0043] The difference between the comparative example and Example 3 is that the acid-base buffer layer only uses sodium bicarbonate.
[0044] Comparative Example 2 Comparative Example 2 provides an intelligent release feed additive.
[0045] The difference between the comparative example and Example 3 is that the acid-base buffer layer only uses magnesium oxide.
[0046] Comparative Example 3 Comparative Example 3 provides an intelligent release feed additive.
[0047] The difference between the comparative example and Example 3 is that the weight ratio of sodium bicarbonate to magnesium oxide is 1:1.
[0048] Comparative Example 4 Comparative Example 4 provides an intelligent release feed additive.
[0049] The difference between the comparative example and Example 3 is that the intelligent release feed additive does not include an acid-base buffer layer.
[0050] Comparative Example 5 Comparative Example 5 provides an intelligent release feed additive.
[0051] The difference between the comparative example and Example 3 is that the intelligent release feed additive does not include a buffer layer.
[0052] Performance Testing The intelligent release feed additives obtained in Examples 1-18 and Comparative Examples 1-5 were tested for their performance. The results are shown in Table 4 below.
[0053] (1) Add the compound feed additive at an addition amount of 2 g / kg to ordinary feed (purchased from Beijing Jiahe Mufeng Feed Co., Ltd.), mix well, and obtain beef cattle feed.
[0054] (2) A total of 120 Simmental cattle aged 12 months were selected and randomly divided into 24 groups, with 5 cattle in each group; Feeding management: 18 groups were fed with the beef cattle feed provided in Examples 1-18; 5 groups were fed with the beef cattle feed provided in Comparative Examples 1-5; 1 group was fed with ordinary feed (as a blank control group); the test period was 30 days, during which the animals were fed in a single trough twice a day, with free access to food and water, and all conditions were basically the same.
[0055] Test: Before the experiment, weigh the fasting weight of each cow; during the experiment, record the feed intake of each group of beef cattle in detail every day; after the experiment, weigh the fasting weight of each cow. The average daily weight gain, average daily feed intake and feed-to-meat ratio of each beef cattle were calculated comprehensively, and the results are shown in Table 4 below.
[0056] Average daily weight gain of each cow = (average weight of each group of cows at the end of the test - average initial weight of each group of cows) / 150 Average daily feed intake per cow = 30-day feed consumption per group of cows / 150 Feed-to-meat ratio = average daily feed intake per cow / average daily weight gain per cow.
[0057] Table 4 Test results of beef cattle feeding experiment According to the test results in Table 4, the beef cattle feed obtained in Examples 1-18 and Comparative Examples 1-5 and commercial beef cattle feed were used to feed beef cattle for 30 days; the average daily weight gain of beef cattle fed with Examples 1-18 was 1.42-1.66 kg / head, and the feed-to-meat ratio was 7.12-8.11, while the average daily weight gain of beef cattle fed with Comparative Examples 1-5 and commercially available feed was 0.86-1.31 kg / head, and the feed-to-meat ratio was 8.63-9.78. Obviously, the average daily weight gain of beef cattle fed with Examples 1-18 was significantly higher than that of beef cattle fed with Comparative Examples 1-5 and commercially available feed, and the feed-to-meat ratio of beef cattle fed with Examples 1-18 was significantly lower than that of beef cattle fed with Comparative Examples 1-5 and commercially available feed. Therefore, it is shown that the intelligent release feed additive provided by the present application can intelligently regulate the changes in gastrointestinal pH during the digestion process of beef cattle, and release nutrients under appropriate conditions, thereby ensuring that beef cattle can fully absorb nutrients, improve feed-to-meat ratio, improve growth performance and health status, and thus increase the breeding efficiency of the farm, and has good economic value and application prospects.
[0058] From the test results of Examples 1-5 and Comparative Examples 1-3, it can be seen that the average daily weight gain of beef cattle fed with the beef cattle feed obtained in Example 1-5 is 1.47-1.66 kg / head, and the feed-to-meat ratio is 7.29-7.62; while the average daily weight gain of beef cattle fed with the beef cattle feed obtained in Comparative Examples 1-3 is only 1.03-1.31 kg / head, and the feed-to-meat ratio is as high as 8.63-9.13. Therefore, it is shown that the present application uses sodium bicarbonate and magnesium oxide as the acid-base buffer layer, and controls the weight ratio of the two within the range of 1:(0.17-0.36), and the use effect of the obtained intelligent release feed additive is good; further comparison shows that the average daily weight gain of beef cattle fed with the beef cattle feed obtained in Examples 2-4 is 1.53-1.66 kg / head, and the feed-to-meat ratio is only 7.29-7.45 (≤7.50), which means that the present application further controls the weight ratio of sodium bicarbonate and magnesium oxide in the acid-base buffer layer within the range of 1:(0.21-0.32), and the use effect of the obtained intelligent release feed additive is better, and the feed-to-meat ratio of the obtained beef cattle is higher.
[0059] From the test results of Examples 3 and 6-11, it can be seen that Examples 3 and 6-9 use a mixture of cellulose acetate phthalate and tetrandrine as the sustained-release layer material, and the obtained beef cattle feed has an average daily weight gain of 1.50-1.66 kg / head, and the feed-to-meat ratio is 7.20-7.60; while Examples 10-11 use a mixture of hydroxypropyl methylcellulose phthalate and tetrandrine, or a mixture of cellulose acetate phthalate and polyglucosamine (1-4)-2-amino-BD glucose as the sustained-release layer material, and the obtained beef cattle feed has an average daily weight gain of only 1.42-1.45 kg / head, and the feed-to-meat ratio is 7.93-8.03; therefore, it is explained that the present application further uses a mixture of cellulose acetate phthalate and tetrandrine as the sustained-release layer material, and the obtained intelligent release feed additive has a better growth-promoting effect on beef cattle, thereby improving the growth performance of beef cattle.
[0060] From the test results of Example 3, Examples 12-18, and Comparative Examples 4-5, it can be seen that the average daily weight gain of beef cattle fed with the beef cattle feed obtained in Examples 3 and 12-17 is 1.46-1.66 kg / head, and the feed-to-meat ratio is 7.12-7.74; the average daily weight gain of beef cattle fed with the beef cattle feed obtained in Example 18 is 1.43 kg / head, and the feed-to-meat ratio is 8.11; the average daily weight gain of beef cattle fed with the beef cattle feed obtained in Comparative Examples 4-5 is 0.98-1.04 kg / head, and the feed-to-meat ratio is 9.23-9.39, indicating that the present application adopts nutrient particles, sustained-release layer and acid-base buffer layer to prepare intelligent release feed additives, and the weight ratio of the three is controlled within the range of 5: (0.3-1): (0.3-1), and the obtained intelligent release feed additives have a better growth-promoting effect on beef cattle, thereby improving the growth performance of beef cattle.
[0061] In summary, the intelligent release feed additive provided in the present application can intelligently regulate the changes in gastrointestinal pH during the digestion process of beef cattle, and release nutrients under appropriate conditions, thereby ensuring that beef cattle can fully absorb nutrients, improve feed-to-meat ratio, improve growth performance and health status, and thereby increase the breeding efficiency of the farm, and has good economic value and application prospects.
[0062] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.
Claims
1. An intelligent release feed additive, characterized in that: It includes nutrient particles, and a slow-release layer and an acid-base buffer layer sequentially wrapped on the outer surface of the nutrient particles; The sustained-release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4)-2-amino-BD glucose, polymethyl methacrylate and hydroxypropyl methylcellulose phthalate; The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1: (0.17-0.36).
2. The intelligent release feed additive according to claim 1, characterized in that: The acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1:(0.21-0.32).
3. The intelligent release feed additive according to claim 1, characterized in that: The sustained-release layer is a mixture of cellulose acetate phthalate and tetrandrine.
4. The intelligent release feed additive according to claim 1, characterized in that: The weight ratio of the cellulose acetate phthalate to tetrandrine is 1:(0.1-0.5).
5. The intelligent release feed additive according to claim 1, characterized in that: The weight ratio of the cellulose acetate phthalate to tetrandrine is 1:(0.2-0.4).
6. The intelligent release feed additive according to claim 1, characterized in that: The nutritional particles include the following components in parts by weight: 1-2 parts of amino acids, 1-2 parts of minerals and 0.5-0.8 parts of vitamins.
7. The intelligent release feed additive according to any one of claims 1 to 6, characterized in that: The weight ratio of the nutritional particles, the sustained-release layer and the acid-base buffer layer is 5:(0.3-1):(0.3-1).
8. The method for preparing the intelligent release feed additive according to any one of claims 1 to 7, characterized in that: The following steps are involved: The components of the nutritional granules are mixed evenly, and the nutritional granules are obtained by granulation; the surfaces of the nutritional granules are sprayed with moisture, and then mixed with the sustained-release layer material and shaken evenly so that the surfaces of the nutritional granules are completely covered with the sustained-release layer material to obtain prefabricated granules; then the surfaces of the prefabricated granules are sprayed with moisture again, and mixed with the acid-base buffer layer material and shaken evenly so that the surfaces of the prefabricated granules are completely covered with the acid-base buffer layer material to obtain an intelligent release feed additive.
9. Use of the intelligent release feed additive according to any one of claims 1 to 7 in animal feed.
10. A beef cattle feed, characterized in that: The intelligent release feed additive comprises any one of claims 1 to 7; the weight ratio of the intelligent release feed additive to beef cattle feed is 1.5 to 2.5 g / kg.