Moxibustion containing effective substances of ginger and extraction process of moxibustion

Abstract

The invention relates to moxa-moxibustion containing effective substances of fresh ginger and an extraction process of the moxa-moxibustion. The moxibustion disclosed by the invention consists of ginger slices, a rubber ring, a transparent base, a paper tube, a metal sheet and a moxa cake, wherein the ginger slices are prepared by compounding supercritical extraction ginger effective substances and double-layer non-woven fabrics. The extraction process of the effective substances of the fresh ginger comprises the steps of raw material preparation, extraction and separation of ginger essential oil, treatment of fresh ginger residues, extraction of gingerol, microwave-ultrasonic assisted extraction, concentration extraction, supercritical CO2 further purification and the like. The invention further relates to preparation and application of the eutectic reagent. The ginger slice compound disclosed by the invention is prepared through the operations of effective substance treatment, coating, compound molding, drying and curing, cutting and packaging and the like. The advanced extraction technology and the material compounding technology are applied to the moxibustion product, a new thought and method are provided for innovation of the moxibustion technology, the limitation of traditional ginger-separated moxibustion on materials and technologies is broken through, and the components, the structure and the performance of the moxibustion product are remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine moxibustion, and in particular to a moxibustion containing ginger effective substances and an extraction process thereof. Specifically, it is a technical improvement of incorporating ginger effective substances extracted by a specific process into moxibustion products to enhance the effect of moxibustion, and also involves the application of related extraction processes in the preparation of traditional Chinese medicine physiotherapy products. Background Art

[0002] Moxibustion is a traditional Chinese medicine treatment method. It uses the warm stimulation and medicinal ingredients of burning moxa to act on acupuncture points or painful areas, which can harmonize body functions and has multiple effects. Moxibustion with ginger has a long history and is recorded in many ancient books. It can treat a variety of diseases. Moxibustion uses the warm stimulation produced by burning moxa to act on specific acupuncture points or painful areas of the human body. It not only uses the heat of the moxibustion fire, but also relies on the medicinal ingredients contained in the moxa itself. The effect of moxibustion is to stimulate the meridians and promote the circulation of qi and blood, thereby achieving the purpose of harmonizing body functions. Specifically, moxibustion has the effects of warming yang and replenishing qi, warming the meridians and unblocking the collaterals, removing blood stasis and dispersing knots, and replenishing the middle and replenishing qi. It can coordinate the balance of yin and yang, strengthen the body and eliminate evil, and regulate the endocrine system. It has shown positive effects in the treatment of various diseases and daily health care.

[0003] Moxibustion through ginger is recorded in Ming Yang Jizhou's Acupuncture and Moxibustion: "For moxibustion, slice ginger into slices as thick as coins, place them on the tongue acupoints, and then moxibustion them." Later, in Ming Zhang Jingyue's Illustrated Book of Classics, it was mentioned that for the treatment of hemorrhoids, "simply cut ginger into thin slices, place them on the painful part of the hemorrhoids, and moxibustion three times on the ginger. The yellow water will come out and dissipate by itself." Moxibustion through ginger is used to treat vomiting, diarrhea, abdominal pain, wind-cold-dampness arthralgia, impotence, dysmenorrhea, peripheral facial nerve paralysis and other diseases caused by cold. Traditional moxibustion through ginger requires complicated material preparation, difficult operation, and moxa wool is easy to scatter and burn the skin. Specifically, the traditional ginger moxibustion has its shortcomings. First, the material preparation process is complicated. It requires preparing ginger, washing, drying, slicing, and pinching moxa. There are many manual steps and it is difficult to implement. Second, the operation is not easy to achieve. Other people must help with the moxibustion treatment. It is difficult for one person to complete the operation independently. Third, the pinched moxa is not strong and can easily scatter and fall on the skin during the burning process, causing burns.

[0004] Although the existing ginger moxibustion uses ginger powder slices to solve some problems, the effective ingredients of ginger, volatile essential oil and gingerol, are lost in the process of grinding dried ginger into powder slices, and the effect is not as good as the traditional ginger moxibustion. The existing moxibustion uses finished ginger powder instead of freshly cut ginger slices, which can keep the effect longer. However, the existing ginger moxibustion products use dried ginger powder to make ginger powder slices, which has disadvantages. In the process of making fresh ginger into dried ginger and then into ginger powder, the effective ingredients, volatile essential oil and gingerol, will be lost to varying degrees. The effect of the ginger moxibustion is greatly reduced compared with the traditional ginger moxibustion. Although the existing ginger moxibustion products have solved the problems of complex use and operational risks, they are still lacking in effect. Summary of the invention

[0005] The purpose of the present invention is to provide a moxibustion containing ginger effective substances and an extraction process thereof. By incorporating ginger effective substances extracted by a specific process into moxibustion products, a technical improvement in improving the moxibustion effect is achieved. At the same time, the application of the relevant extraction process in the preparation of traditional Chinese medicine physiotherapy products is also provided to solve the problems of low content of ginger effective ingredients and low release efficiency in existing ginger moxibustion products.

[0006] The present invention applies advanced extraction technology and material composite technology to moxibustion products, providing new ideas and methods for the innovation of moxibustion technology, breaking the limitations of traditional ginger moxibustion in materials and processes, and making significant improvements in the composition, structure and performance of moxibustion products. It will help promote the entire moxibustion industry to develop in a more efficient, safer and more scientific direction, meet the higher requirements of modern people for Chinese medicine physiotherapy products, and promote the wider application of Chinese medicine moxibustion technology in the field of modern medical and health care.

[0007] The invention provides a moxibustion device containing ginger effective ingredients, comprising ginger slices, rubber rings, a transparent base, a paper tube, a metal sheet and moxa cakes. The ginger slices are made of supercritically extracted ginger effective ingredients and a double-layer non-woven fabric with a pore size of 8-12 μm. The total content of ginger effective ingredients in the ginger slices is 99-100%.

[0008] The effective ingredients of ginger extracted by supercritical extraction can reach 99-100%, ensuring that there are enough ginger essential oils and gingerols to play a role during the moxibustion process; compared with the traditional ginger moxibustion, the effective ingredients of ginger are lost to varying degrees during the preparation process of ginger powder tablets made by grinding dry ginger into powder, the present invention can make fuller use of the medicinal value of ginger; at the same time, during moxibustion, the high content of effective ingredients can more effectively stimulate acupuncture points, promote the circulation of qi and blood, and enhance the effects of warming yang and replenishing qi, warming the meridians and unblocking the collaterals, eliminating blood stasis and dispersing nodules, and replenishing the middle and replenishing qi, thereby improving the therapeutic effect of moxibustion.

[0009] The structural design of ginger slices compounded with double-layer non-woven fabric with a pore size of 8-12μm has many advantages; on the one hand, the double-layer non-woven fabric can serve as a good carrier of ginger effective substances, making it evenly distributed and slowly releasing the effective ingredients; on the other hand, the appropriate pore size can ensure air permeability, so that the heat and medicinal ingredients generated by moxibustion combustion can better pass through the ginger slices to act on human skin; at the same time, the use of non-woven fabric avoids the problem of moxa easily scattering and scalding the skin in traditional ginger moxibustion, thereby improving the safety of use; moreover, in the preparation process of this composite ginger slice, the process parameters of the steps of effective substance treatment, coating, compounding and molding, drying and curing can be controlled to ensure the quality stability of the product, so that the effective ingredient content and release performance of each slice of ginger are relatively consistent, thereby improving the overall performance of the product and the user experience.

[0010] The effective substances in ginger are extracted by combining multiple technologies, including supercritical CO2 extraction of ginger essential oil, microwave-ultrasound assisted extraction of gingerol combined with aqueous two-phase extraction and further purification by supercritical CO2. Supercritical CO2 extraction is used to efficiently extract ginger essential oil under relatively mild conditions, while retaining its active ingredients. Microwave-ultrasound assisted extraction utilizes the synergistic effect of microwaves and ultrasound to improve the extraction efficiency of gingerol and shorten the extraction time. Aqueous two-phase extraction achieves the preliminary purification of gingerol, and further purification by supercritical CO2 further improves the purity of gingerol. The combination of multiple technologies comprehensively improves the extraction effect of effective substances in ginger.

[0011] Preferably, the ginger effective substances include volatile components ginger essential oil and gingerol, and the preparation method thereof includes supercritical CO2 extraction of ginger essential oil, microwave-ultrasound-assisted extraction of gingerol combined with aqueous two-phase extraction, and further purification by supercritical CO2.

[0012] Ginger essential oil is one of the important active ingredients in moxibustion. With its volatile characteristics, it can quickly penetrate the skin during moxibustion, integrate into the human meridians, accelerate blood circulation, and help the warm power of moxibustion to reach the whole body more efficiently, thereby enhancing the effect of warming the meridians. At the same time, its soothing properties can enable users to better relax their bodies and minds during moxibustion, reduce stress and anxiety, and accept moxibustion conditioning in a more peaceful state. Moreover, ginger essential oil, in the process of synergizing with gingerol, jointly enhances the medicinal value of ginger's effective substances and promotes the improvement of the overall efficacy of moxibustion.

[0013] Gingerol plays a key role in moxibustion. Its warming properties can warm the human meridians, dispel the cold evil in the meridians, effectively improve the meridian blockage and poor blood circulation caused by the cold evil, and enhance the effectiveness of moxibustion in warming the meridians and dredging the collaterals; in addition, gingerol helps to eliminate blood stasis and lumps in the body, and has a certain improvement effect on lumps, nodules and other problems caused by blood stasis, thereby enhancing the effect of moxibustion in the treatment of related diseases; moreover, during the moxibustion process, gingerol can stimulate and enhance the efficacy of the effective substances in ginger, promote their synergistic effect, thereby improving the pharmacological effects of moxibustion on the human body and further improving the therapeutic effect.

[0014] The supercritical CO2 extraction method utilizes the special properties of CO2 in a supercritical state to efficiently extract ginger essential oil from ginger. Under relatively low temperature and specific pressure, volatile components such as ginger essential oil can be quickly dissolved in the supercritical CO2 fluid, avoiding the destruction of the active ingredients of ginger essential oil due to high temperature. Compared with traditional extraction methods, this method has higher extraction efficiency and can obtain purer and more active ginger essential oil. The traditional steam distillation method takes a long time to extract and may cause some ginger essential oil components to change at high temperatures. The supercritical CO2 extraction method can effectively overcome these problems, so that the extracted ginger essential oil can better exert its volatile components in moxibustion applications to promote blood circulation and soothe the body and mind.

[0015] No organic solvent is used in the supercritical CO2 extraction process, which avoids the impact of organic solvent residues on the quality of ginger essential oil and reduces environmental pollution. In addition, through secondary separation, ginger essential oil can be accurately separated from other components to obtain ginger essential oil with higher purity, which is beneficial to improve the quality and efficacy stability of ginger effective substances in moxibustion products.

[0016] Microwave-ultrasonic assisted extraction combines the thermal effect of microwaves and the cavitation effect of ultrasound. Microwaves can rapidly heat up the inside of ginger residue and accelerate the dissolution of gingerol. The cavitation effect produced by ultrasound can destroy the plant cell walls, making it easier for gingerol to be released from the cells into the solvent. The synergistic effect of the two greatly improves the extraction efficiency of gingerol. Compared with the traditional single extraction method, more gingerol can be obtained in a shorter time. In the traditional immersion extraction method, it takes several hours or even longer to achieve a similar extraction effect, and the extraction rate is low.

[0017] After extraction, a two-phase aqueous extraction method is used, and a two-phase aqueous system is formed using a salt solution, so that gingerol is selectively distributed to the upper phase to achieve preliminary separation from impurities; this method is based on the different distribution coefficients of different components in the two-phase aqueous system, and can effectively remove some large molecular impurities and water-soluble impurities, improve the purity of gingerol, and lay the foundation for subsequent further purification and application; at the same time, the two-phase aqueous extraction operation is relatively mild, has little effect on the activity of gingerol, and is conducive to maintaining its medicinal value.

[0018] The gingerol extracted and preliminarily purified in the previous steps is further purified by supercritical CO2 to more accurately remove residual impurities and further improve the purity of gingerol. The application of high-purity gingerol in moxibustion products can ensure the stability and reliability of its medicinal efficacy, making the effects of moxibustion on warming the meridians, unblocking the collaterals, removing blood stasis and dispersing nodules on the human body more significant.

[0019] The ginger effective substances, ginger essential oil and gingerol, prepared through this series of extraction and purification methods, can improve the overall quality of the product when used in moxibustion products. The high content and high purity of ginger effective substances help them to release active ingredients more effectively during the moxibustion process, enhance the stimulating effect of moxibustion on acupoints, and promote the circulation of qi and blood, thereby improving the therapeutic effect of moxibustion, providing users with a better physical therapy experience, and also enhancing the competitiveness of the product in the market.

[0020] Preferably, the extraction process of the ginger effective substance comprises the following steps: S11 raw material preparation: fresh ginger is selected to be cleaned and cut into blocks or sheets, ginger raw material is prepared;Ensure the cleanliness of raw material, avoid impurities from mixing and affecting subsequent extraction effect, fresh ginger contains rich active ingredients such as ginger essential oil and gingerol, and its cell structure is complete, which is conducive to the release of active ingredients in subsequent extraction process. Prepare low eutectic reagent, standby;Eutectic reagent plays an important role in subsequent ginger slag processing steps, can change the property of solvent system, improve the solubility of gingerol in solvent, contribute to more fully extracting gingerol from ginger slag, and can also realize recycling in subsequent steps, reduce cost and embody environmental protection.

[0021] S12 Ginger essential oil extraction: Put the ginger raw material into the extraction kettle of the supercritical CO2 extraction device, set the extraction pressure to 1.5-45MPa and the extraction temperature to 32-80℃; supercritical CO2 is used as an extraction agent, which has gas-like diffusivity and liquid-solubility, and can quickly and efficiently dissolve volatile components such as ginger essential oil in ginger; compared with traditional extraction methods, supercritical CO2 extraction avoids the destruction of the active ingredients of ginger essential oil by high temperature, and at the same time does not use organic solvents, reducing solvent residues and environmental pollution, and can obtain purer and more active ginger essential oil.

[0022] CO2 becomes liquid after passing through the condenser, and enters the extraction kettle after being pressurized by a high-pressure pump and heated by a heat exchanger; the CO2 supply system is started, and the CO2 gas enters the condenser and is converted into liquid due to the cooling effect. The liquid CO2 is then extracted by the high-pressure pump and pressurized. The pressurized liquid CO2 is then heated to the set extraction temperature through a heat exchanger, and after becoming a supercritical CO2 fluid, it enters the extraction kettle stably at a specific flow rate, fully contacts the ginger raw material, so that volatile components such as ginger essential oil are gradually dissolved in the supercritical CO2 fluid, and a supercritical CO2 fluid mixture containing the extract is formed; the entire process ensures that the supercritical CO2 fluid is fully in contact with the ginger raw material in a stable state and under appropriate conditions, so that the ginger essential oil is fully dissolved therein, and a fluid mixture containing the extract is formed, providing a good foundation for subsequent separation steps.

[0023] S13 Ginger essential oil separation: The supercritical CO2 fluid containing the extract is throttled and expanded into the separator, and two-stage separation is adopted; the first-stage separation pressure is 25-6.5MPa and the temperature is 25-75℃, and the ginger essential oil component with lower solubility is precipitated at the bottom; the second-stage separation pressure is 20-6.0MPa and the temperature is 20-70℃, and other components with higher solubility are separated, and the ginger essential oil with higher purity is obtained by mixing; the adoption of two-stage separation is based on the difference in solubility of different components in supercritical CO2 fluid at different pressures and temperatures. The first-stage separation is at higher pressure and temperature, so that the ginger essential oil component with lower solubility is precipitated preferentially; the second-stage separation is at slightly lower pressure and temperature, and other components with higher solubility are further separated; through this precise two-stage separation, impurities can be effectively removed, and ginger essential oil with higher purity can be obtained, thereby improving product quality and ensuring that ginger essential oil can better exert its volatile medicinal effects in moxibustion applications, such as promoting blood circulation, soothing the body and mind, etc.

[0024] S14 Ginger residue treatment: The ginger residue after ginger essential oil extraction is dried in a vacuum drying oven at 50-65°C to constant weight, crushed through a 40-80 mesh sieve, and further crushed into nano-scale ultrafine powder; the ginger residue is vacuum dried to constant weight to remove moisture, which is convenient for subsequent crushing and processing operations and prevents moisture from affecting the subsequent solvent extraction effect; the ginger residue is further crushed into nano-scale ultrafine powder after crushing and sieving, which increases the specific surface area of ​​the ginger residue, is beneficial to the subsequent dissolution of gingerol, enables the gingerol to be more fully in contact with the solvent, and improves the extraction efficiency.

[0025] The ginger residue powder is mixed with a low eutectic reagent-water mixed solvent in a mass volume ratio of 1:15-20, and the solvent is slowly added under stirring. After the addition, stirring is continued for 5-10 minutes to evenly disperse the powder. The addition of the low eutectic reagent changes the solvent environment, increases the solubility of gingerol in the solvent, makes it easier for gingerol to dissolve from the ginger residue, provides a good material basis for subsequent microwave-ultrasound-assisted extraction, and helps to improve the extraction rate of gingerol.

[0026] S15 Microwave-ultrasonic assisted extraction: The mixed material is subjected to microwave-ultrasonic treatment, with ultrasonic power of 200-400w, microwave power of 100-200w, temperature of 35-50℃, and time of 20-40min; the thermal effect generated by microwave power of 100-200w causes the internal temperature of the mixed material to rise rapidly, accelerates the movement of gingerol molecules, and promotes its dissolution from the ginger residue powder; the cavitation effect of ultrasonic power of 200-400w can destroy the plant cell wall, making gingerol easier to release into the solvent; the synergistic effect of the two greatly shortens the extraction time and improves the extraction efficiency of gingerol. Compared with the traditional single extraction method, more gingerol can be obtained in a shorter time, and at the same time, the activity of gingerol is less affected, which is conducive to maintaining its medicinal value.

[0027] The clear liquid is filtered, and the residue is extracted with a solvent for 2-3 times and then the supernatant is combined; the insoluble impurities are filtered to remove, and a solution containing gingerol is obtained. The residue is extracted for multiple times and then the supernatant is combined to further improve the extraction rate of gingerol, ensure that as much gingerol as possible is extracted, and improve the utilization rate of raw materials.

[0028] S16 concentration extraction: the combined supernatant is concentrated under reduced pressure to obtain a crude gingerol extract, an ammonium sulfate solution with a concentration of 0.25-0.5 g / ml is added thereto, the mass ratio of the ammonium sulfate solution to the crude gingerol extract is 35-50%, a two-phase aqueous solution is formed by vortexing, and the upper phase is concentrated by vacuum distillation, ethanol is added to the upper phase concentrate to recover the low eutectic reagent and dissolve the gingerol at the same time, and the ethanol phase is distilled and dried under reduced pressure to obtain a preliminarily purified gingerol extract; the solvent can be effectively removed at low temperature by vacuum concentration to obtain a crude gingerol extract, and then the ammonium sulfate solution is used to form a two-phase aqueous solution, and gingerol and impurities are preliminarily separated based on the distribution difference of different components, the upper phase is concentrated by vacuum distillation to further enrich the gingerol, and then ethanol is added to precipitate to recover the low eutectic reagent to reduce the cost and dissolve the gingerol at the same time, and finally the preliminarily purified gingerol extract is obtained by vacuum distillation. This series of operations not only improves the purity of gingerol, but also realizes the recycling of reagents, laying a good foundation for subsequent product applications. Ammonium sulfate is a commonly used salt that performs well in the two-phase aqueous extraction process. By changing the ionic strength and polarity of the solution, it can promote the gingerol crude extract to form a two-phase aqueous system. Its advantages are that it is relatively cheap and easy to obtain, and has a good separation effect on gingerol at an appropriate concentration. In the two-phase aqueous extraction of step S162, the concentration of ammonium sulfate solution is 0.3-0.4 g / ml, taking into account the properties of the gingerol crude extract and the formation conditions of the two-phase aqueous system, because a lower concentration cannot effectively form a two-phase aqueous system, resulting in gingerol. It cannot be well separated from impurities; too high a concentration will cause some unnecessary chemical reactions, or make the aqueous two-phase system too complicated, affecting the extraction efficiency and purity of gingerol; the mass ratio of the addition of ammonium sulfate solution to the crude gingerol extract is 40-45%, which can make the aqueous two-phase system reach a better equilibrium state, which is conducive to the enrichment of gingerol in the upper phase. If the addition amount is too small, the aqueous two-phase cannot be fully formed, resulting in incomplete separation of gingerol; too much addition will cause other impurities to enter the upper phase in large quantities, reducing the purity of gingerol.

[0029] S17 Supercritical CO2 further purification: The preliminarily purified gingerol extract is transferred to a supercritical CO2 extraction device, and further purified and extracted with an ethanol-water solution with a volume concentration of 50-65% as an entrainer under the conditions of pressure 2.0-2.8MPa, temperature 30-60℃, and fluid flow 25-30L / h. After removing the solvent, gingerol with higher purity is obtained. Supercritical CO2 is used again to accurately remove residual impurities and further improve the purity of gingerol; the application of high-purity gingerol in moxibustion products can ensure the stability and reliability of its efficacy, making the effects of moxibustion on the human body such as warming the meridians and unblocking the collaterals, removing blood stasis and dispersing nodules more significant, and improving product quality and therapeutic effects.

[0030] In the treatment of ginger residue, the addition of low eutectic reagent changes the properties of the solvent system, enhancing its solubility for gingerol; gingerol in ginger residue is easier to dissolve in this optimized solvent environment. Compared with traditional solvents, gingerol can be extracted from ginger residue more effectively, improving the extraction rate of gingerol, thereby improving the utilization rate of ginger raw materials and reducing resource waste.

[0031] In the subsequent extraction process, the low eutectic reagent can be recovered by adding ethanol precipitation, which not only reduces the production cost, but also reduces the emission and pollution of chemical reagents to the environment, reflecting the concept of environmental protection and economy. At the same time, the recovered low eutectic reagent can be used again in the extraction process of ginger effective substances, forming a recycling system, which further improves the sustainability and economy of the entire process.

[0032] Furthermore, in the step S11, the low eutectic reagent is prepared in the raw material preparation, and the specific steps include: The hydrogen bond acceptor betaine and the hydrogen bond donor glucose are mixed in a molar ratio of 1:1-5, and stirred and heated at 80-100°C and 400-600rpm / min for 1-2 hours to form a uniform and transparent eutectic reagent for use; the hydrogen bond acceptor betaine and the hydrogen bond donor glucose are in a molar ratio of 1:1-5, and this ratio range has been determined through research and experiments, and can form a stable eutectic system with specific properties in subsequent reactions; the appropriate temperature and stirring speed ensure that the betaine and glucose molecules fully move and interact with each other, and the high temperature helps to break the original interaction force between the molecules, so that the hydrogen bond acceptor and the donor are more likely to form new hydrogen bonds; stirring ensures the uniform mixing of the materials, promotes the rapid reaction, and finally forms a uniform and transparent eutectic reagent.

[0033] In the ginger residue treatment step S14, a low eutectic reagent-water mixed solvent is used, and the low eutectic reagent accounts for 40-75% of the total volume; this low eutectic reagent has unique physical and chemical properties such as changing the solvent polarity and reducing the viscosity. The mixed solution of the low eutectic reagent and water creates favorable conditions for the subsequent extraction process of the effective substances in ginger.

[0034] Furthermore, the step S16 of concentration extraction comprises the following specific steps: S161 vacuum concentration: the supernatant after microwave-ultrasound-assisted extraction and filtration is transferred to a rotary evaporator, heated to 40-60°C under a pressure of -0.08MPa to -0.1MPa for 1-2 hours, and the density of the concentrated solution is controlled at 1.15-1.25g / ml to obtain a crude gingerol extract; vacuum concentration can reduce the boiling point of the solvent, evaporate the solvent at a lower temperature, and avoid the destruction of gingerol due to high temperature. At the same time, the density is controlled to obtain a crude extract of a suitable concentration, which is convenient for subsequent two-phase aqueous extraction operations and improves the stability of the two-phase aqueous system and the extraction effect.

[0035] S162 Two-phase aqueous extraction: slowly add an ammonium sulfate solution with a concentration of 0.25-0.5g / ml to the crude gingerol extract, so that the added amount is 35-50% relative to the mass of the crude gingerol extract, and use a vortex mixer at 1000-2000rpm to stir for 3-10 minutes to form a two-phase aqueous solution. After stabilization, centrifuge to obtain an upper phase, which is then transferred to a vacuum distillation device for concentration to further increase the concentration of gingerol; utilize the distribution differences of different components in the two-phase aqueous system to selectively distribute gingerol to the upper phase to achieve preliminary separation from impurities. This method is based on the difference in the chemical properties of the substance, can effectively remove some large molecular impurities and water-soluble impurities, improve the purity of gingerol, and provide conditions for subsequent further purification. At the same time, the operation is relatively mild and has little effect on the activity of gingerol.

[0036] S163 precipitation and dissolution: add ethanol with a volume equivalent to 1-3 times of the upper phase to the upper phase, separate the precipitated low eutectic reagent by centrifugation at 3000-5000rpm for 5-10 minutes, and realize the recovery of the low eutectic reagent. At the same time, transfer the ethanol phase containing gingerol to a vacuum distillation drying device, distill at 40-60℃ for 1-3 hours under a pressure of -0.09MPa to -0.1MPa to remove ethanol, and obtain a preliminary purified gingerol extract. Add ethanol to the upper phase concentrate, the addition of ethanol changes the polarity of the solution, precipitates the low eutectic reagent for recovery, and the gingerol is dissolved in the ethanol phase; by centrifugation, the precipitate and the solution are separated, the low eutectic reagent is recovered and reused, the cost is reduced, and the gingerol solution is further purified, so as to prepare for the subsequent vacuum distillation and drying to obtain a preliminary purified gingerol extract.

[0037] Preferably, the composite method of the ginger slices is to composite the ginger effective substance with a double-layer non-woven fabric, which specifically comprises the following steps: S21 Effective substance processing: Gingerol is made into nano-sized particles by high-pressure homogenization. The extracted gingerol solution is passed through a high-pressure homogenizer and repeatedly passed through a homogenization valve at a pressure of 100-200MPa to break and refine the gingerol particles to obtain nano-sized gingerol. Gingerol with nano-sized particles has a larger specific surface area, and can release active ingredients faster and more fully during moxibustion, improve its bioavailability, enhance the stimulation and pharmacological effects of gingerol on human acupoints, and better play the effects of warming meridians and unblocking collaterals, removing blood stasis and dispersing nodules. Gingerol with nano-sized particles is mixed with ginger essential oil at a mass ratio of 1:10-20, so that the two can work synergistically and enrich the medicinal value of ginger effective substances. After mixing, the mixture is mixed with the binder polyvinyl alcohol in a mass ratio of 1:0.5-2 and stirred to obtain a ginger effective substance coating liquid. The stirring speed is controlled at 100-500 rpm and the stirring time is 15-60 minutes. The appropriate ratio and stirring conditions ensure that the components in the coating liquid are evenly dispersed, the binder can effectively adhere to the effective ingredients, and a good material basis is provided for the subsequent coating process, ensuring that the effective ingredients on the ginger slices are evenly distributed and firm.

[0038] S22 coating: first preheat the coating equipment to 30-40℃ to provide a suitable coating temperature environment for the coating liquid, so that the coating liquid maintains good fluidity, and then place a double-layer non-woven fabric with a pore size of 8-12μm on the coating equipment, and coat it at a speed of 5-15m / min and a pressure of 0.4-0.5MPa to make the ginger effective substance coating liquid evenly distributed on the surface of the non-woven fabric; ensure that each non-woven fabric can carry an appropriate amount of ginger effective substance, ensure the consistency and uniformity of the effective ingredient content of the ginger slices, and evenly release the medicinal effect during moxibustion, thereby improving product quality and usage effect.

[0039] The double-layer non-woven fabric structure has good air permeability. During the coating process, its pore size is appropriate, which can not only allow the coating liquid to penetrate into the interior smoothly, but also ensure that during moxibustion, heat and effective ingredients can effectively act on human skin through the non-woven fabric, while preventing the effective ingredients from dissipating too quickly, playing a certain sustained-release effect; and the non-woven fabric is soft and fits well with the skin, which can improve the comfort of the user.

[0040] S23 Compounding and Forming: The double-layer non-woven fabric coated with ginger effective substances is compounded by hot pressing, and the coated double-layer compounded non-woven fabric is sent into a hot press. The hot pressing temperature is set to 80-150℃, the pressure is set to 0.5-2MPa, and the time is set to 5-30s. The adhesive is cured under the action of hot pressing to firmly bond the two layers of non-woven fabrics together to form a stable ginger slice structure, and the ginger slices after preliminary compounding are obtained; this can prevent the effective substances from falling off or the non-woven fabrics from being delaminated during use, ensure the integrity and durability of the ginger slices, and ensure that the ginger effective substances can play a role continuously and stably during the moxibustion process; precise control of process parameters such as hot pressing temperature, pressure and time can ensure the bonding effect while avoiding damage to the ginger effective substances due to excessive temperature or excessive pressure, or affecting production efficiency due to excessive time. Appropriate parameter settings help to improve the overall quality of the ginger slices, achieve the best balance between the physical properties and medicinal properties of the ginger slices, and improve the reliability and repeatability of the product.

[0041] S24 Drying and curing: Place the composite ginger slices into the drying equipment and dry them at 45-55℃ for 2-4 hours. This temperature range is conducive to the volatilization of the remaining solvent and further solidifies the binder, thereby enhancing the bonding strength between the non-woven fabric layers and further stabilizing the structure of the ginger slices. The drying process changes the ginger slices from a moist state to a dry state, preventing problems such as mold and deterioration caused by residual moisture during storage and use, thereby extending the shelf life of the ginger slices and ensuring the stability of product quality. The relatively mild drying temperature avoids the damage of gingerol and ginger essential oil, the effective substances of ginger, to high temperatures, ensuring that the effective ingredients remain active during the drying process. When the drying temperature is too high, the effective ingredients will volatilize, decompose or deteriorate, reducing the efficacy of the ginger slices. The appropriate drying time ensures the adequacy of the drying effect, so that the ginger slices reach the ideal degree of dryness and quality standards.

[0042] S25 Cutting and packaging: Use cutting equipment to cut the dried ginger slices into circles with a diameter of 3-5 cm according to the predetermined size, ensuring that the edges are neat and the uniform size specifications facilitate the user to accurately place the ginger slices during moxibustion, thereby improving the convenience and standardization of operation; the finished ginger slices are obtained by heat-sealing them in plastic film bags, which can effectively isolate the outside air, moisture and microorganisms, prevent the ginger slices from moisture, oxidation and contamination, and further protect the activity and quality of the effective substances in ginger.

[0043] The present invention provides a moxibustion containing ginger effective ingredients, and the assembly steps specifically include the following operations: S31 Fixing ginger slices: fix the ginger slices containing ginger effective substances made by the above process on a plastic transparent base with a rubber ring; the rubber ring has a certain elasticity and friction, and can tightly clamp the ginger slices so that they will not move or fall off easily during the moxibustion process, ensuring that the ginger slices can accurately cover the acupuncture points or painful areas, so that the ginger effective substances can continue to play a role in a continuous and stable manner, and ingredients such as ginger essential oil and gingerol can be effectively transmitted to the skin surface through the ginger slices, thereby stimulating the acupuncture points, promoting the circulation of qi and blood, and achieving the effects of moxibustion such as warming yang and replenishing qi, warming the meridians and unblocking collaterals; the design of the plastic transparent base makes it convenient for users to observe whether there is drug leakage or displacement of the ginger slices during use. Users can adjust the position of the ginger slices or perform other necessary operations in time according to the observation results to ensure the effect and safety of moxibustion.

[0044] S32 Install the paper tube: Install the paper tube on the transparent base with the ginger slices fixed on it, which provides a relatively closed space for the burning of the moxa cake. The paper tube can prevent the ashes and sparks generated by the burning of the moxa cake from scattering around, avoiding scalding the user or causing safety accidents such as fire, thus improving the safety of the moxibustion process. The height and diameter of the paper tube can be used to control the oxygen supply and heat dissipation during the burning of the moxa cake, thereby adjusting the temperature and duration of the moxibustion. To a certain extent, the paper tube can play a role in heat preservation and insulation, so that the heat generated by the burning of the moxa cake can be transferred upward in a more concentrated manner and act on the human body through the ginger slices. At the same time, it also helps the volatilization and diffusion of the effective substances in ginger, so that ingredients such as ginger essential oil and gingerol can be better dissipated into the surrounding air with the heat and absorbed by the human body, thereby enhancing the overall effect of moxibustion.

[0045] S33 Place the metal sheet and moxa cake: The metal sheet is stuck in the paper tube. The metal sheet has good thermal conductivity, which can make the heat generated by the burning of the moxa cake more evenly distributed under the ginger slice, avoiding local overheating or overcooling, ensuring that the thermal stimulation of moxibustion is uniform and moderate, and improving the comfort of the user. At the same time, the metal sheet can also play a certain role in heat insulation, preventing the high temperature of the moxa cake from being directly transmitted to the bottom of the paper tube when it burns, extending the service life of the paper tube, and further ensuring the safety of the moxibustion process. The moxa cake is placed on the metal sheet. The moxa cake is the main heat source for moxibustion, and the warm stimulation generated during its combustion is one of the important factors for moxibustion to work. The heat released when the moxa cake burns can not only warm the acupuncture points and promote blood circulation, but also stimulate the medicinal effects of ginger effective substances, so that it can better play a synergistic role. The assembled moxibustion containing ginger effective substances promotes the volatilization of ginger essential oil according to the unique structure, so that it enters the human meridians faster and enhances the effect of warming and unblocking the meridians; at the same time, it also helps the absorption of ingredients such as gingerol, improves its pharmacological effects on the human body, and thus enhances the therapeutic effect of moxibustion.

[0046] Through the above steps, the assembly of the moxibustion containing ginger effective ingredients is completed, and the various components work together to provide users with a moxibustion product that is easy to use, safe and effective.

[0047] A moxibustion structure containing ginger effective ingredients comprises ginger slices, rubber rings, a transparent base, a paper tube, a metal sheet and a moxa cake; the edge of the ginger slice is fixed on the transparent base through the rubber ring, the rubber ring surrounds the ginger slice, the transparent base is a sheet structure, provides a placement plane for the ginger slice, has a certain thickness and is made of transparent material; the paper tube is a hollow columnar structure, the bottom of which is installed on the transparent base, and the paper tube surrounds the area where the ginger slice is located; the metal sheet is a circular thin sheet, which is placed inside the paper tube and below the ginger slice, and the edge of the metal sheet is in contact with the inner wall of the paper tube; the moxa cake is a cylindrical structure, which is placed above the metal sheet, and the diameter of the moxa cake is smaller than the inner diameter of the paper tube; the ginger slice is connected to the transparent base through the rubber ring to form a combination, the paper tube cooperates with the combination, the metal sheet is placed between the paper tube and the combination, and the moxa cake is located above the metal sheet, together forming a complete moxibustion structure.

[0048] In a moxibustion structure containing ginger effective substances used in the present invention, the ginger slices are fixed above the transparent base by the rubber ring, and the rubber ring surrounds the edge of the ginger slices, and uses its own elasticity and friction to tightly clamp the ginger slices, ensuring that their position is stable during the moxibustion process, so that the ginger effective substances can be effectively transmitted to the skin surface through the ginger slices; the transparent base provides a support platform for the ginger slices and the rubber ring, and its transparent material facilitates the user to observe the status of the ginger slices during use, such as drug leakage, displacement, etc., so as to make timely adjustments; the paper tube is installed above the transparent base to provide a relatively closed space for the burning of the moxa cake, which can prevent the ashes and sparks generated by the burning of the moxa cake from scattering everywhere, avoid scalding the user or causing safety accidents such as fire, and at the same time control the oxygen supply and heat dissipation of the moxa cake during combustion through its own size. , adjust the temperature and duration of moxibustion, play a role of heat preservation and heat insulation to a certain extent, and promote the volatilization and diffusion of the effective ginger substances in the ginger slices; the metal sheet is arranged inside the paper tube, stuck on the inner wall of the paper tube, and located below the ginger slices. Its good thermal conductivity makes the heat generated by the burning of the moxa cake more evenly distributed below the ginger slices, avoiding local overheating or overcooling, improving the comfort of the user, and at the same time playing a role of heat insulation, preventing the high temperature of the burning moxa cake from being directly transferred to the bottom of the paper tube, thereby extending the service life of the paper tube; the moxa cake is placed above the metal sheet as the main heat source for moxibustion. The warm stimulation generated by its combustion can warm the acupuncture points, promote blood circulation, and stimulate the medicinal effects of the effective ginger substances, and cooperate with the effective ingredients in the ginger slices to exert the effects of moxibustion such as warming yang and replenishing qi, warming the meridians and unblocking the collaterals, eliminating blood stasis and dispersing nodules, and replenishing the middle and replenishing qi.

[0049] In summary, the present invention has the following beneficial effects: 1. The present invention significantly improves the content, purity and release efficiency of ginger essential oil and gingerol, the effective components of ginger, through a carefully designed ginger effective substance extraction process, including supercritical CO2 extraction of ginger essential oil, microwave-ultrasound-assisted and aqueous two-phase extraction and supercritical CO2 further purification of gingerol, as well as an optimized ginger slice compounding method and reasonable moxibustion assembly steps, thereby improving the overall therapeutic effect and health-care effect of moxibustion; 2. In the process of extracting effective substances from ginger, the application and recycling of low eutectic reagents in the extraction process of the present invention reduces the waste of chemical reagents and the pollution to the environment, embodies the concept of environmental protection, and at the same time, improves the utilization rate of ginger raw materials by optimizing the process, reduces the production cost, has certain economic value, and meets the requirements of sustainable development; 3. Different from the preparation process of traditional ginger moxibustion, ginger slices are made by compounding ginger effective substances with double-layer non-woven fabrics. The process parameters of nano-processing, coating, composite molding, drying and curing of effective substances are precisely controlled to ensure that the effective ingredients of ginger slices are evenly distributed and slowly released, and have good air permeability and fit. At the same time, the assembly structure of moxibustion is reasonably designed, and the functions of each component are clear and synergistic, making the product safer, more convenient and comfortable during use, overcoming the shortcomings of traditional ginger moxibustion, such as complex material preparation, difficult operation and easy burns. 4. The present invention comprehensively uses a variety of advanced technologies and innovative processes to form a complete and scientific system from raw material processing to final product assembly. This innovative model provides new ideas and methods for the development of moxibustion technology, breaking the technical and technological limitations of traditional ginger moxibustion. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 It is a schematic diagram of the overall structure of moxibustion containing ginger effective ingredients; In the picture: 1. Mugwort cake; 2. Metal sheet; 3. Paper tube; 4. Transparent base; 5. Ginger slices; 6. Rubber ring. DETAILED DESCRIPTION

[0051] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

[0052] Example 1

[0053] Step 1 Preparation of ginger effective ingredients: S11 raw material preparation: prepare ginger raw material; mix betaine and glucose in a molar ratio of 1:5, stir and heat at 80°C and 400 rpm / min for 1 hour to prepare a low eutectic reagent for use; S12 Ginger essential oil extraction: put the ginger raw material into the extraction kettle of the supercritical CO2 extraction device, set the extraction pressure to 1.5MPa and the extraction temperature to 32℃; S13 Ginger essential oil separation: The supercritical CO2 fluid containing the extract is throttled and expanded into the separator, with a first-stage separation pressure of 6.5 MPa and a temperature of 25°C; a second-stage separation pressure of 6.0 MPa and a temperature of 20°C, and the ginger essential oil with a higher purity is obtained by mixing; S14 Ginger residue treatment: Dry the ginger residue after extracting ginger essential oil in a vacuum drying oven at 50°C to constant weight, crush it through a 40-mesh sieve, and then further crush it into nano-scale ultrafine powder; Mix the ginger residue powder with a low eutectic agent-water mixed solvent (the low eutectic agent accounts for 40% of the total volume) at a mass volume ratio of 1:20, slowly add the solvent under stirring conditions, and continue stirring for 5 minutes after adding to make the powder evenly dispersed; S15 Microwave-ultrasound assisted extraction: The mixed material was subjected to microwave-ultrasound treatment, with an ultrasonic power of 200w and a microwave power of 100w, and treated at 35°C for 20min. The residue was extracted twice with a solvent and the supernatant was combined and filtered; S16 concentrated extraction: transfer the supernatant after microwave-ultrasound assisted extraction and filtration to a rotary evaporator, heat to 40°C under -0.1MPa pressure for 1 hour, control the density of the concentrated solution at 1.15g / ml, and obtain a crude gingerol extract; slowly add an ammonium sulfate solution with a concentration of 0.25g / ml to the crude gingerol extract, so that the amount added is 35% relative to the mass of the crude gingerol extract, and use a vortex mixer to stir for 3 minutes at 1000rpm to form a two-phase aqueous solution, centrifuge to obtain an upper phase after stabilization, and then transfer it to a vacuum distillation device for concentration; add ethanol with a volume equivalent to 1 times that of the upper phase to the upper phase, separate the precipitated low eutectic reagent by centrifugation at 3000rpm for 5 minutes, and vacuum distill and dry the ethanol phase containing gingerol, and distill at 40°C for 1 hour at -0.1MPa to remove ethanol to obtain a preliminary purified gingerol extract; S17: Further purification by supercritical CO2: The preliminarily purified gingerol extract was transferred to a supercritical CO2 extraction device, and further purified and extracted using a 50% volume concentration of ethanol-water solution as an entrainer under the conditions of a pressure of 2.0 MPa, a temperature of 30°C, and a fluid flow rate of 25 L / h, and gingerol with a higher purity was obtained after removing the solvent; Step 2: Compounding of ginger slices: S21: Treatment of effective substances: The gingerol solution obtained by extraction is passed through a high-pressure homogenizer, and repeatedly passed through a homogenizing valve at a pressure of 100 MPa. The obtained nano-particle gingerol is mixed with ginger essential oil at a mass ratio of 1:20, and then mixed with binder polyvinyl alcohol at a mass ratio of 1:2 to obtain a ginger effective substance coating liquid. The stirring speed is controlled at 100 rpm for 15 minutes. S22 coating: first preheat the coating equipment to 30°C, then place a double-layer non-woven fabric with a pore size of 8 μm on the coating equipment, and coat it at a speed of 5 m / min and a pressure of 0.4 MPa, so that the ginger effective substance coating liquid is evenly distributed on the surface of the non-woven fabric; S23 compounding and molding: sending the coated double-layer composite non-woven fabric into a hot press, setting the hot pressing temperature to 80° C., the pressure to 0.5 MPa, and the time to 5 seconds, curing the binder under the action of hot pressing to obtain ginger slices after preliminary compounding; S24 drying and curing: placing the compounded ginger slices into a drying device and drying at 45°C for 2 hours; S25 Cutting and packaging: Cut the dried ginger slices into a circle with a diameter of 3 cm according to a predetermined size, ensure that the edges are neat, and heat-seal the ginger slices in a plastic film bag to obtain the finished ginger slices; Step 3: Moxibustion Assembly: The prepared ginger slices containing ginger effective substances are fixed on a plastic transparent base using a rubber ring; a paper tube is installed on the transparent base with the ginger slices fixed; a metal sheet is stuck in the paper tube, and an moxa cake is placed on the metal sheet to obtain an assembled moxa containing ginger effective substances.

[0054] The moxibustion structure containing ginger effective substances comprises ginger slices 1, rubber rings 2, transparent bases 3, paper tubes 4, metal sheets 5 and moxa cakes 6; the specific structure is as follows: the edge of the ginger slices 1 is fixed on the transparent base 3 through the rubber rings 2, the rubber rings 2 surround the ginger slices 1, the transparent base 3 is a sheet structure, providing a placement plane for the ginger slices 1, and has a certain thickness and is made of transparent material; the paper tube 4 is a hollow columnar structure, the bottom of which is installed on the transparent base 3, and the paper tube 4 surrounds the area where the ginger slices 1 are located; the metal sheet 5 is a circular thin sheet, which is placed inside the paper tube 4 and below the ginger slices 1, and the edge of the metal sheet 5 is in contact with the inner wall of the paper tube 4; the moxa cake 6 is a cylindrical structure, which is placed above the metal sheet 5, and the diameter of the moxa cake 6 is smaller than the inner diameter of the paper tube 4; the ginger slices 1 are connected to the transparent base 3 through the rubber rings 2 to form a combination, the paper tube 4 cooperates with the combination, the metal sheet 5 is placed between the paper tube 4 and the combination, and the moxa cake 6 is located above the metal sheet 5, together forming a complete moxibustion structure.

[0055] Example 2

[0056] Step 1 Preparation of ginger effective ingredients: S11 raw material preparation: prepare ginger raw material; mix betaine and glucose in a molar ratio of 1:1, stir and heat at 100°C and 600rpm / min for 2 hours to prepare a low eutectic reagent for use; S12 Ginger essential oil extraction: put the ginger raw material into the extraction kettle of the supercritical CO2 extraction device, set the extraction pressure to 45MPa and the extraction temperature to 80℃; S13 Ginger essential oil separation: The supercritical CO2 fluid containing the extract is throttled and expanded into the separator, with a first-stage separation pressure of 25MPa and a temperature of 75°C; a second-stage separation pressure of 20MPa and a temperature of 70°C, and the ginger essential oil with a higher purity is obtained by mixing; S14 Ginger residue treatment: Dry the ginger residue after extracting ginger essential oil in a vacuum drying oven at 65°C to constant weight, crush it through an 80-mesh sieve, and then further crush it into nano-scale ultrafine powder; Mix the ginger residue powder with a low eutectic agent-water mixed solvent (the low eutectic agent accounts for 75% of the total volume) at a mass volume ratio of 1:15, slowly add the solvent under stirring conditions, and continue stirring for 10 minutes after adding to make the powder evenly dispersed; S15 Microwave-ultrasound assisted extraction: The mixed material was subjected to microwave-ultrasound treatment, with an ultrasonic power of 400w, a microwave power of 200w, a temperature of 50°C, and a time of 40min. The residue was extracted with a solvent for 3 times and the supernatant was combined and filtered; S16 concentrated extraction: the supernatant after microwave-ultrasound assisted extraction and filtration was transferred to a rotary evaporator, heated to 60°C at -0.08MPa pressure for 2 hours, and the density of the concentrated solution was controlled at 1.25g / ml to obtain a crude gingerol extract; an ammonium sulfate solution with a concentration of 0.5g / ml was slowly added to the crude gingerol extract so that the amount added was 50% relative to the mass of the crude gingerol extract, and a vortex mixer was used to stir for 10 minutes at 2000rpm to form a two-phase aqueous solution, and after stabilization, the upper phase was centrifuged to obtain a transfer to a vacuum distillation device for concentration; ethanol with a volume equivalent to 1 times that of the upper phase was added to the upper phase, and the precipitated low eutectic reagent was separated by centrifugation at 5000rpm for 10 minutes, and the ethanol phase containing gingerol was vacuum distilled and dried, and the ethanol was distilled at 60°C at -0.09MPa pressure for 3 hours to remove ethanol to obtain a preliminarily purified gingerol extract; S17: Further purification by supercritical CO2: The preliminarily purified gingerol extract was transferred to a supercritical CO2 extraction device, and further purified and extracted using an ethanol-water solution with a volume concentration of 65% as an entrainer under the conditions of a pressure of 2.8 MPa, a temperature of 60°C, and a fluid flow rate of 30 L / h, and gingerol with a higher purity was obtained after removing the solvent; The combination of ginger slices in step 2 and the assembly of moxa in step 3 are the same as in Example 1, and the assembled moxa containing ginger effective substances is obtained.

[0057] Example 3

[0058] Step 1: Preparation of ginger effective substances is the same as in Example 1; Step 2: Compounding of ginger slices: S21: Treatment of effective substances: The gingerol solution obtained by extraction is passed through a high-pressure homogenizer, and repeatedly passed through a homogenizing valve at a pressure of 200 MPa. The obtained nano-particle gingerol is mixed with ginger essential oil at a mass ratio of 1:10, and then mixed with binder polyvinyl alcohol at a mass ratio of 2:1 to obtain a ginger effective substance coating liquid. The stirring speed is controlled at 500 rpm, and the stirring time is 60 minutes. S22 coating: first preheat the coating equipment to 40°C, then place a double-layer non-woven fabric with a pore size of 12 μm on the coating equipment, and coat it at a speed of 15 m / min and a pressure of 0.5 MPa, so that the ginger effective substance coating liquid is evenly distributed on the surface of the non-woven fabric; S23 compounding and molding: the coated double-layer composite non-woven fabric is sent into a hot press, and the hot pressing temperature is set to 150°C, the pressure is 2MPa, and the time is 30s. The binder is cured under the action of hot pressing to obtain ginger slices after preliminary compounding.

[0059] S24 Drying and curing: Place the compounded ginger slices into a drying device and dry at 55°C for 4 hours.

[0060] S25 Cutting and packaging: Cut the dried ginger slices into a circle with a diameter of 5 cm according to a predetermined size, ensure that the edges are neat, and heat-seal the ginger slices in a plastic film bag to obtain the finished ginger slices; Step 3: The assembly of the moxa stick is the same as in Example 1, and the assembled moxa stick containing the effective ingredient of ginger is obtained.

[0061] Example 4

[0062] Step 1 Preparation of ginger effective ingredients: S11 raw material preparation: prepare ginger raw material; mix betaine and glucose in a molar ratio of 1:3, stir and heat at 90°C and 500 rpm / min for 1.5 hours to prepare a low eutectic reagent for use; S12 Ginger essential oil extraction: put the ginger raw material into the extraction kettle of the supercritical CO2 extraction device, set the extraction pressure to 2MPa and the extraction temperature to 35℃; S13 Ginger essential oil separation: The supercritical CO2 fluid containing the extract is throttled and expanded into the separator, with a first-stage separation pressure of 15MPa and a temperature of 50°C; a second-stage separation pressure of 10MPa and a temperature of 45°C, and the ginger essential oil with a higher purity is obtained by mixing; S14 Ginger residue treatment: Dry the ginger residue after extracting ginger essential oil in a vacuum drying oven at 60°C to constant weight, crush it through a 60-mesh sieve, and then further crush it into nano-scale ultrafine powder; Mix the ginger residue powder with a low eutectic agent-water mixed solvent (the low eutectic agent accounts for 60% of the total volume) at a mass volume ratio of 1:18, slowly add the solvent under stirring conditions, and continue stirring for 5-10 minutes after adding to make the powder evenly dispersed; S15 Microwave-ultrasound assisted extraction: The mixed material was subjected to microwave-ultrasound treatment, with an ultrasonic power of 300w, a microwave power of 150w, a temperature of 40°C, and a time of 30min. The residue was extracted with a solvent for 3 times and the supernatant was combined and filtered; S16 concentrated extraction: the supernatant after microwave-ultrasound assisted extraction and filtration was transferred to a rotary evaporator, heated to 50°C at -0.09MPa pressure for 1.5 hours, and the density of the concentrated solution was controlled at 1.20g / ml to obtain a crude gingerol extract; an ammonium sulfate solution with a concentration of 0.35g / ml was slowly added to the crude gingerol extract, so that the amount added was 45% relative to the mass of the crude gingerol extract, and a vortex mixer was used to stir for 5 minutes at 1500rpm to form a two-phase aqueous solution, and after stabilization, the upper phase was centrifuged to obtain a transfer to a vacuum distillation device for concentration; ethanol with a volume equivalent to twice that of the upper phase was added to the upper phase, and the precipitated low eutectic reagent was separated by centrifugation at 4000rpm for 8 minutes, and the ethanol phase containing gingerol was vacuum distilled and dried, and the ethanol was distilled at 50°C at -0.095MPa pressure for 2 hours to remove ethanol to obtain a preliminarily purified gingerol extract; S17: Further purification by supercritical CO2: The preliminarily purified gingerol extract was transferred to a supercritical CO2 extraction device, and further purified and extracted using an ethanol-water solution with a volume concentration of 60% as an entrainer under the conditions of a pressure of 2MPa, a temperature of 35°C, and a fluid flow rate of 28L / h, and gingerol with a higher purity was obtained after removing the solvent; Step 2: Compounding of ginger slices: S21: Treatment of effective substances: The gingerol solution obtained by extraction is passed through a high-pressure homogenizer, and repeatedly passed through a homogenizing valve at a pressure of 150 MPa. The obtained nano-particle gingerol is mixed with ginger essential oil at a mass ratio of 1:15, and then mixed with binder polyvinyl alcohol at a mass ratio of 1:1 to obtain a ginger effective substance coating liquid. The stirring speed is controlled at 300 rpm, and the stirring time is 40 minutes. S22 coating: first preheat the coating equipment to 35°C, then place a double-layer non-woven fabric with a pore size of 10 μm on the coating equipment, and coat it at a speed of 10 m / min and a pressure of 0.45 MPa, so that the ginger effective substance coating liquid is evenly distributed on the surface of the non-woven fabric; S23 compounding and molding: sending the coated double-layer composite non-woven fabric into a hot press, setting the hot pressing temperature to 100° C., the pressure to 1 MPa, and the time to 15 seconds, curing the binder under the action of hot pressing to obtain a preliminarily compounded ginger slice; S24 drying and curing: putting the compounded ginger slices into a drying device and drying them at 50°C for 3 hours; S25 Cutting and packaging: Cut the dried ginger slices into a circle with a diameter of 4 cm according to a predetermined size, ensure that the edges are neat, and heat-seal the ginger slices in a plastic film bag to obtain the finished ginger slices; Step 3: Moxibustion Assembly: The prepared ginger slices containing ginger effective substances are fixed on a plastic transparent base using a rubber ring; a paper tube is installed on the transparent base with the ginger slices fixed; a metal sheet is stuck in the paper tube, and an moxa cake is placed on the metal sheet to obtain an assembled moxa containing ginger effective substances.

[0063] Comparative Example 1 Select fresh ginger, wash and dry it, and cut it into ginger slices with a thickness of 0.25 cm; manually pinch an appropriate amount of moxa and pinch it into moxa cones with a diameter of 1.5 cm and a height of 2 cm, and set them aside; place the sliced ​​ginger slices above the acupuncture points or painful areas; place the moxa cones on the ginger slices, light the moxa cones to perform ginger moxibustion, and obtain moxibustion containing effective ingredients from ginger.

[0064] Comparative Example 2 Fresh ginger is selected, dried ginger is made, and then crushed into ginger powder; the ginger powder is mixed with starch in a mass ratio of 3:1, and an appropriate amount of water is added and stirred evenly to make ginger powder slices, which are dried for later use; according to the design of existing products, the ginger powder slices are placed on a corresponding base device, and the remaining operations are the same as step 3 of embodiment 1 of the present invention, to obtain an assembled moxa stick containing ginger effective substances.

[0065] Comparative Example 3 Step 1 Preparation of ginger effective ingredients The ginger essential oil is extracted by a traditional steam distillation method: fresh ginger is cut into small pieces, put into a distillation device, an appropriate amount of water is added, heated and distilled, and the distillate is collected and separated to obtain the ginger essential oil; gingerol is extracted by a traditional immersion extraction method: the ginger residue after the ginger essential oil is extracted is immersed in an ethanol solution for 10 hours, and an extract containing gingerol is obtained after filtering, and then the extract is concentrated, purified and other conventional operations are performed to obtain gingerol, and other operations are the same as step 1 of Example 1 of the present invention; The combination of ginger slices in step 2 and the assembly of moxa in step 3 are the same as in Example 1, and the assembled moxa containing ginger effective substances is obtained.

[0066] Comparative Example 4 Step 1: Preparation of ginger effective substances is the same as step 1 of Example 1 of the present invention; Step 2: Compounding of ginger slices: The ginger effective substance is not subjected to high-pressure homogenization and nano-processing, and the gingerol solution is directly mixed with ginger essential oil and a binder in proportion to prepare a coating solution; a single-layer non-woven fabric is used for coating, and the ginger effective substance is coated on the single-layer non-woven fabric with a pore size of 10 μm. The coating speed, pressure and other conditions, drying and other operations are the same as those in step 2 of embodiment 1 of the present invention, and the hot pressing compounding operation is omitted; The assembly of the moxa stick in step 3 is the same as step 3 of embodiment 1 of the present invention, and the assembled moxa stick containing the effective ingredient of ginger is obtained.

[0067] Comparative Example 5 The preparation of ginger effective substances in step 1 and the compounding of ginger slices in step 2 are the same as those in Example 1; Step 3: Assembly of moxa: When assembling, do not use a plastic transparent base. Fix the ginger slices directly on a simple wooden base with a rubber ring, and then place the moxa cake directly under the ginger slices in the paper tube to obtain the assembled moxa containing ginger effective ingredients.

[0068] 1. Experimental Methods 1.1 Ginger Extract Content and Purity High performance liquid chromatography (HPLC) was used to determine the content and purity of gingerol and ginger essential oil: a certain amount of ginger extract or ginger slices containing ginger effective substances in each embodiment and comparative example was accurately weighed, ultrasonically extracted with an appropriate organic solvent methanol, filtered and fixed to a volumetric flask to prepare a test solution; a suitable chromatographic column C18 reverse phase column was selected, and gradient elution was performed with methanol-water as the mobile phase, the flow rate was set to 1.0 mL / min, and the detection wavelength was determined according to the maximum absorption wavelength of the main components of gingerol and ginger essential oil; gingerol and ginger essential oil standards were accurately weighed, dissolved in methanol and prepared into a series of standard solutions of different concentrations, sampled and analyzed, and a standard curve was drawn with peak area versus concentration; the test solution was sampled, and the content of each component of gingerol and ginger essential oil was calculated according to the standard curve, and its purity was calculated by area normalization method; and the extraction rate of the effective components of ginger in each group was calculated at the same time.

[0069] 1.2 Release rate The in vitro release rate was determined by using a dialysis bag method: ginger slices or moxibustion products (burned parts such as moxa cakes are removed) containing ginger effective ingredients in each embodiment and comparative example were cut into small pieces, a certain amount was accurately weighed, and placed in a dialysis bag, and both ends were clamped with dialysis bag clamps to ensure sealing; a phosphate buffer solution with a pH of 7.4 was selected as the release medium, and a certain volume was measured and placed in a 37°C constant temperature oscillating water bath; the dialysis bag containing the sample was placed in the release medium, and the constant temperature oscillation at a speed of 100 rpm was turned on, and a certain volume of the release medium was taken out at different time points such as 0.5, 1, 2, 4, 6, 8, 12, and 24 hours, and an equal amount of fresh release medium at the same temperature was supplemented; the content of gingerol and ginger essential oil in the taken out release medium was determined by the above-mentioned HPLC method, and the cumulative release rate was calculated according to the change of the drug content in the release medium over time.

[0070] 1.3 Effects of moxibustion Through clinical observation of human experiments: 270 patients with diseases or symptoms suitable for moxibustion treatment, such as rheumatoid arthritis, dysmenorrhea, spleen and stomach deficiency, etc., were selected, and strict screening was carried out according to the disease type and diagnostic criteria to ensure the homogeneity of the patients; the patients were randomly divided into 9 groups, 30 people in each group, and the moxibustion products of Examples 1-4 and Comparative Examples 1-5 were used respectively, and moxibustion treatment was performed according to the prescribed acupoints and methods, 2-3 times a week, each moxibustion time was 15-30 minutes, and one course of treatment was 4-6 weeks.

[0071] Symptom scoring: Corresponding symptom scoring standards were developed according to the symptom characteristics of different diseases. For patients with rheumatoid arthritis, the visual analogue scale was used to evaluate the degree of joint pain, with 0 points indicating no pain and 10 points indicating severe pain. For patients with dysmenorrhea, the degree of dysmenorrhea was assessed, with 0 points indicating no pain and 10 points indicating severe pain. Scores were performed before treatment, during treatment (every 1-2 weeks), and after treatment, and the symptom improvement rate was calculated using the following formula: symptom improvement rate = (pre-treatment score - post-treatment score) / pre-treatment score × 100%.

[0072] 2. Experimental results Table 1 Summary of the extraction rate and purity of ginger active ingredients in various examples and comparative examples (unit: %)

[0073] Table 2 Summary of the 24-hour cumulative release rate of the ginger active ingredients in each embodiment and comparative example (unit: %)

[0074] Table 3 Summary of the results of symptom improvement rate of moxibustion application in various embodiments and comparative examples (unit: %)

[0075] 3. Results Analysis 3.1 Extraction rate of active ingredients from ginger The extraction rates of the ginger active ingredients in Examples 1-4 are between 8.60-8.75%, which are relatively close and higher than those in the comparative example. Among them, the extraction rate of Example 4 is the highest, reaching 8.75%, indicating that its extraction process is relatively better in these examples and can more effectively obtain active ingredients from the ginger raw material; the difference in extraction rate between the examples is relatively small, indicating that the advanced extraction processes such as supercritical CO2 extraction and microwave-ultrasound assisted extraction adopted as a whole have good stability and reliability.

[0076] The extraction rate of Comparative Example 1 is the lowest, only 5.20%. This is because it adopts the traditional ginger moxibustion method, does not perform special effective ingredient extraction on ginger, and simply slices it for use, resulting in a large number of effective ingredients not being fully utilized and remaining in the raw material; the extraction rate of Comparative Example 2 is 6.50%. After the ginger is made into dry ginger powder, some effective ingredients are lost during the processing. Although ginger powder slices are made, the extraction efficiency is still low; Comparative Example 3 adopts the traditional extraction method, and the extraction rate is 7.80%. Although it is higher than the first two comparative examples, it is still significantly lower than the embodiment. This shows that the traditional steam distillation method and immersion extraction method have limited efficiency in extracting the effective ingredients of ginger; the extraction rate of comparative example 4 is 7.00%. Although the initial steps of preparing the effective ingredients of ginger are the same as those of Example 1, the key steps such as high-pressure homogenization and nano-treatment are lacking in the ginger slice compounding process, which affects the dissolution of the effective ingredients and the subsequent treatment effects, resulting in a lower extraction rate; the extraction rate of comparative example 5 is 8.61%. The preparation of the effective ingredients of ginger and the compounding of ginger slices are the same as those of Example 1, but the structure changes during the moxibustion assembly. However, judging from the extraction rate data, this structural change has no significant effect on the extraction rate.

[0077] 3.2 Ginger active ingredient content and purity 3.2.1 Ginger essential oil The ginger essential oil content in Examples 1-4 is between 45.19% and 46.58%, which is relatively stable and high. The ginger essential oil content in Example 2 is the highest, which is 46.58%. This is related to the use of higher extraction pressure and temperature in the ginger essential oil extraction step. These conditions are conducive to the dissolution of ginger essential oil from ginger.

[0078] In the comparative examples, the ginger essential oil content is significantly lower than that in the embodiments. The ginger essential oil content of comparative example 1 is only 12.84%, because the traditional ginger moxibustion does not enrich the ginger essential oil; the ginger essential oil content of comparative example 2 is 23.27%, and a large amount of ginger essential oil is lost in the preparation process of dried ginger; comparative example 3 adopts the traditional steam distillation method, and the extraction efficiency is limited, and the content is 32.51%; comparative example 4 is 30.08%, and the lack of key processing steps affects the ginger essential oil content; the ginger essential oil content of comparative example 5 is 46.01%, which is similar to that of embodiment 1, which once again shows that it is similar to embodiment 1 in the preparation and compounding process of ginger effective substances.

[0079] At the same time, the purity of the ginger essential oils in Examples 1-4 is very high, between 95-96%, and the purity of Examples 1 and 4 reaches 96%, indicating that the extraction and purification process can effectively remove impurities to obtain high-purity ginger essential oil. The purity of Examples 2 and 3 is 95%. There may be very small amounts of impurities remaining during the extraction and purification process, but the overall purity is still at a high level; in the comparative examples, the purity is significantly lower, the purity of Comparative Example 1 is 61%, and it contains a large amount of impurities; Comparative Example 2 is 72%, and certain impurities are introduced during the preparation of dried ginger powder and subsequent processing; Comparative Example 3 is 74%, and the traditional extraction method has a poor effect on impurity removal; Comparative Example 4 is 76%, and process defects lead to more impurities; The purity of Comparative Example 5 is 95%, which is equivalent to the embodiment, indicating that the method for preparing ginger effectives of the present invention has better purity control in the preparation stage of the effective ingredient.

[0080] 3.2.2 Gingerol The gingerol content in Examples 1-4 is between 53.41-54.81%, which is complementary to the ginger essential oil content, and the sum of the two is close to 100%; the gingerol content in Example 4 is the highest, which is 54.81%, thanks to the optimization of process parameters throughout the extraction and purification process, which makes the gingerol extraction more complete and less lost.

[0081] In the comparative examples, the gingerol content is also lower than that in the embodiments. The gingerol content of comparative example 1 is 19.02%, and the traditional ginger moxibustion does not concentrate the gingerol; the content of comparative example 2 is 27.80%, and there is a loss in the processing of dry ginger powder; the content of comparative example 3 is 35.12%, and the traditional immersion extraction method is incomplete; the content of comparative example 4 is 42.44%, and the lack of key steps affects the extraction; the content of comparative example 5 is 53.98%, which is similar to that of embodiment 1, indicating that the gingerol situation is similar in the early stage of the preparation of the effective substance.

[0082] At the same time, the purity of gingerol in Examples 1-4 is between 90-92%, and the purity of Example 1 is 92%, indicating that its extraction and purification process has a good purification effect on gingerol; the purity of Examples 2-4 is between 90-91%, and there may be a small amount of impurities affecting the purity during the extraction and purification process, but the overall quality of gingerol can still be guaranteed to be relatively high.

[0083] Among the comparative examples, the purity of comparative example 1 was 72%, and the traditional ginger moxibustion method had many impurities; the purity of comparative example 2 was 80%, and impurities were introduced during the preparation process of ginger powder slices; the purity of comparative example 3 was 81%, and the purification by the traditional extraction method was limited; the purity of comparative example 4 was 81%, and process defects led to residual impurities; the purity of comparative example 5 was 91%, which was equivalent to that of the embodiment, once again indicating that the purity of the process of the present invention was acceptable in the preparation stage of the active ingredient.

[0084] 3.3 24-hour cumulative release rate of ginger active ingredients The 24-hour cumulative release rates of Examples 1-4 are all very high, ranging from 92% to 95%, and are very close. The release rates of Examples 3 and 4 are the highest, reaching 95%, which is related to the process optimization in the ginger slice compounding process. The high-pressure homogenization pressure in Example 3 is relatively high, which is conducive to the nano-ization of gingerol, making it easier to dissolve during the release process; the process parameters of Example 4 are relatively balanced in each step, which also promotes the release of the active ingredient; the release rates of Examples 1 and 2 are 92% and 94%, respectively, which are slightly lower than Examples 3 and 4, but also show that its compounding process can ensure a higher release rate, so that the active ingredient can be released more fully within a certain period of time.

[0085] The release rate of comparative example 1 was the lowest, only 48%. The release of the effective ingredients of ginger was slow and incomplete under the traditional ginger moxibustion method. Since the ginger was not pretreated and optimized for the effective ingredients, it was difficult for the effective ingredients to dissolve from the ginger slices and pass through the dialysis bag under simulated in vitro release conditions. The release rate of comparative example 2 was 51%. Although the ginger powder slices had undergone certain processing, their release performance was still poor. The combination of ginger powder and binder and the characteristics of ginger powder particles affected the release of the effective ingredients. The release rate of comparative example 3 was 63%. The release of the effective ingredients of ginger prepared by the traditional extraction method in the composite sheet was The performance is not as good as that of the embodiment. The changes in the ingredients during the extraction process or the deficiencies in the compounding process lead to the obstruction of the release of the effective ingredients. The release rate of Comparative Example 4 is 68%. The lack of high-pressure homogenization and nano-processing affects the release of the effective ingredients. Although similar coating and other operations as in the embodiment are adopted, the initial state of the effective ingredients is not good, resulting in a lower release rate than that of the embodiment. The release rate of Comparative Example 5 is 93%, which is very close to that of the embodiment. This shows that when the preparation and compounding of the ginger effective substance are the same, although the moxibustion assembly structure is changed, it has little effect on the release rate, indicating that this structural change does not affect the release process of the effective ingredient itself.

[0086] 3.4 Symptom improvement rate of moxibustion application 3.4.1 Rheumatoid arthritis The symptom improvement rates of Examples 1-4 are between 71-75%, with significant effects; the symptom improvement rate of Example 4 is the highest, which is 75%, indicating that it has the best comprehensive effect in the extraction, compounding and moxibustion application of ginger effective ingredients, and can more effectively relieve joint pain, swelling and other symptoms in patients with rheumatoid arthritis; the symptom improvement rate of Example 2 is 74%, which also shows a good therapeutic effect. Its higher ginger essential oil content and optimized process play an important role in anti-inflammatory and analgesic aspects; the symptom improvement rates of Examples 1 and 3 are 71% and 72%, respectively. Although slightly lower than Examples 2 and 4, they can also significantly improve patient symptoms, indicating that its process has certain effectiveness in the treatment of rheumatoid arthritis.

[0087] The symptom improvement rate of comparative example 1 is the lowest, which is only 28%. The traditional ginger moxibustion method has limited therapeutic effect on rheumatoid arthritis due to the low content of effective ingredients in ginger and incomplete release; the symptom improvement rate of comparative example 2 is 30%, and the ginger powder tablets have little effect on improving joint symptoms. Its effective ingredients are insufficient and the release problem makes it unable to play an effective role; the symptom improvement rate of comparative example 3 is 48%. Although the moxibustion product prepared by the traditional extraction method is worse than the first two comparative examples, it is still far inferior to the embodiment, which shows that the traditional process has limitations in the treatment of rheumatoid arthritis; the symptom improvement rate of comparative example 4 is 46%, and the lack of key steps affects the therapeutic effect of the product. Although the release rate is improved compared with comparative examples 1-3, it is still not ideal in actual treatment; the symptom improvement rate of comparative example 5 is 62%, which is lower than that of the embodiment, which shows that when the preparation and compounding of ginger effective substances are the same, the change of moxibustion assembly structure has a greater impact on the therapeutic effect of rheumatoid arthritis, indicating that the moxibustion assembly method and structure of the present invention have an impact on the effective effect of the product.

[0088] 3.4.2 Dysmenorrhea The symptom improvement rates of Examples 1-4 are between 81-84%, all of which can effectively relieve the symptoms of dysmenorrhea. The symptom improvement rate of Example 4 is the highest, which is 84%. Its higher gingerol content and good release performance help to better warm the meridians and dispel cold, promote blood circulation and relieve pain, thereby reducing the degree of dysmenorrhea and associated symptoms; the symptom improvement rates of Examples 1-3 are also relatively high, which are 82%, 81% and 83% respectively, indicating that the moxibustion products of these examples have good effects in treating dysmenorrhea, and their processes can ensure that the effective ingredients of ginger play a role, regulate uterine blood circulation, and relieve uterine smooth muscle spasms.

[0089] The symptom improvement rate of comparative example 1 is the lowest, which is 34%. The traditional ginger moxibustion has limited effect on relieving dysmenorrhea, mainly because the utilization efficiency of its effective ingredients in ginger is low; the symptom improvement rate of comparative example 2 is 45%, and the ginger powder tablets are not effective in treating dysmenorrhea. The preparation process of the ginger powder tablets affects the activity and release of the effective ingredients, and cannot fully exert the effect of warming the meridians and relieving pain; the symptom improvement rate of comparative example 3 is 57%. Although the products prepared by the traditional extraction method are better than the previous two comparative examples, there is still a large gap compared with the embodiments, indicating that the traditional process is insufficient in treating dysmenorrhea; the symptom improvement rate of comparative example 4 is 60%, and the lack of key steps makes it less effective than the embodiments in treating dysmenorrhea. Although the release rate is improved, the state and mode of action of the effective ingredients may affect the final effect; the symptom improvement rate of comparative example 5 is 70%, which is lower than that of the embodiments, indicating that when the preparation and compounding of the ginger effective substances are the same, the change of the moxibustion assembly structure has a greater impact on the therapeutic effect of dysmenorrhea, indicating that in the treatment of dysmenorrhea, the moxibustion assembly method has a significant interference with the main mechanism of action.

Claims

1. A moxibustion method containing ginger effective ingredients, characterized in that: The invention comprises ginger slices, a rubber ring, a transparent base, a paper tube, a metal sheet and a mugwort cake; the ginger slices are made of a composite of ginger effective substances extracted by supercritical extraction and a double-layer non-woven fabric with a pore size of 8-12 μm, and the total content of ginger effective ingredients in the ginger slices is 99-100%.

2. The moxibustion containing ginger effective ingredient according to claim 1, characterized in that: The ginger effective substances include volatile components ginger essential oil and gingerol, and the preparation method thereof includes supercritical CO2 extraction of ginger essential oil, microwave-ultrasound assisted extraction combined with double aqueous phase extraction of gingerol, and supercritical CO2 further purification.

3. The moxibustion containing ginger effective ingredient according to claim 1 or 2, characterized in that: The extraction process of the ginger effective substance specifically comprises the following steps: S11 raw material preparation: select fresh ginger, wash it, cut it into blocks or slices, and prepare ginger raw material; prepare low eutectic reagent and set aside; S12 Ginger essential oil extraction: Put the ginger raw material into the extraction kettle of the supercritical CO2 extraction device, set the extraction pressure to 1.5-45MPa and the extraction temperature to 32-80℃; CO2 becomes liquid through the condenser, and enters the extraction kettle after being pressurized by the high-pressure pump and heated by the heat exchanger; start the CO2 supply system, CO2 gas enters the condenser and is converted into liquid due to the cooling effect, and the liquid CO2 is then extracted by the high-pressure pump and pressurized, and the pressurized liquid CO2 is then heated to the set extraction temperature through the heat exchanger, and becomes a supercritical CO2 fluid, and then enters the extraction kettle stably at a specific flow rate, fully contacts with the ginger raw material, so that volatile components such as ginger essential oil are gradually dissolved in the supercritical CO2 fluid, forming a supercritical CO2 fluid mixture containing the extract; S13 Ginger essential oil separation: The supercritical CO2 fluid containing the extract is throttled and expanded into the separator, and two-stage separation is adopted; the first-stage separation pressure is 25-6.5MPa, the temperature is 25-75°C, and the ginger essential oil component with a smaller solubility is precipitated at the bottom; the second-stage separation pressure is 20-6.0MPa, the temperature is 20-70°C, and other components with a larger solubility are separated, and the ginger essential oil with a higher purity is obtained by mixing; S14 Ginger residue treatment: Dry the ginger residue after extracting ginger essential oil in a vacuum drying oven at 50-65°C to constant weight, crush it through a 40-80 mesh sieve, and then further crush it into nano-scale ultrafine powder; Mix the ginger residue powder with a low eutectic reagent-water mixed solvent at a mass volume ratio of 1:15-20, slowly add the solvent under stirring conditions, and continue stirring for 5-10 minutes after the addition to make the powder evenly dispersed; S15 Microwave-ultrasound assisted extraction: subject the mixed material to microwave-ultrasound treatment, with ultrasonic power of 200-400w, microwave power of 100-200w, temperature of 35-50°C, and time of 20-40min; filter to obtain a clear liquid, extract the residue with a solvent for 2-3 times, and then combine the supernatant; S16 concentration extraction: the combined supernatant is concentrated under reduced pressure to obtain a crude gingerol extract, an ammonium sulfate solution with a concentration of 0.25-0.5 g / ml is added thereto, and the mass ratio of the ammonium sulfate solution to the crude gingerol extract is 35-50%, vortexing to form a two-phase aqueous phase and taking the upper phase to be concentrated by reduced pressure distillation, adding ethanol to the upper phase concentrate to precipitate and recover the low eutectic reagent while dissolving the gingerol, and taking the ethanol phase to be distilled and dried under reduced pressure to obtain a preliminarily purified gingerol extract; S17: Further purification by supercritical CO2: The preliminarily purified gingerol extract is transferred to a supercritical CO2 extraction device, and further purified and extracted with an ethanol-water solution having a volume concentration of 50-65% as an entrainer under the conditions of a pressure of 2.0-2.8 MPa, a temperature of 30-60°C, and a fluid flow rate of 25-30 L / h, to obtain gingerol with a higher purity after removing the solvent.

4. The process for extracting effective substances from ginger according to claim 3, characterized in that: In the step S11, a low eutectic reagent is prepared in the raw material preparation, and the specific steps include: The hydrogen bond acceptor betaine and the hydrogen bond donor glucose are mixed in a molar ratio of 1:1-5, and stirred and heated at 80-100° C. and 400-600 rpm / min for 1-2 hours to form a uniform and transparent low eutectic reagent for standby use; in the ginger residue treatment step S14, the low eutectic reagent-water mixed solvent accounts for 40-75% of the total volume ratio.

5. The process for extracting effective substances from ginger according to claim 3, characterized in that: The step S16 of concentration extraction comprises the following specific steps: S161: Concentration under reduced pressure: transfer the supernatant after microwave-ultrasound-assisted extraction and filtration to a rotary evaporator, heat to 40-60°C under a pressure of -0.08MPa to -0.1MPa for 1-2 hours, and control the density of the concentrate to 1.15-1.25g / ml to obtain a crude gingerol extract; S162 Two-phase aqueous extraction: slowly add a 0.25-0.5 g / ml ammonium sulfate solution to the gingerol crude extract in an amount of 35-50% relative to the mass of the gingerol crude extract, and stir for 3-10 minutes using a vortex mixer at 1000-2000 rpm to form a two-phase aqueous solution, centrifuge to obtain an upper phase after stabilization, and then transfer to a vacuum distillation device for concentration to further increase the concentration of gingerol; S163 precipitation and dissolution: add ethanol with a volume equivalent to 1-3 times of the upper phase to the upper phase, separate the precipitated low eutectic reagent by centrifugation at 3000-5000 rpm for 5-10 minutes to achieve the recovery of the low eutectic reagent, and at the same time, transfer the ethanol phase containing gingerol to a vacuum distillation drying equipment, distill at 40-60°C under a pressure of -0.09MPa to -0.1MPa for 1-3 hours to remove ethanol, and obtain a preliminary purified gingerol extract.

6. The moxibustion containing ginger effective ingredient according to claim 1, characterized in that: The composite method of the ginger slices is to composite the ginger effective substance with the double-layer non-woven fabric, and specifically comprises the following steps: S21: Processing of effective substances: preparing gingerol into nano-sized particles by high-pressure homogenization, passing the extracted gingerol solution through a high-pressure homogenizer, and repeatedly passing through a homogenization valve at a pressure of 100-200 MPa to break and refine the gingerol particles, and mixing the obtained nano-sized gingerol with ginger essential oil at a mass ratio of 1:10-20, and then mixing with a binder polyvinyl alcohol at a mass ratio of 1:0.5-2 to obtain a ginger effective substance coating liquid, wherein the stirring speed is controlled at 100-500 rpm, and the stirring time is 15-60 minutes; S22 coating: first preheat the coating equipment to 30-40°C, then place a double-layer non-woven fabric with a pore size of 8-12 μm on the coating equipment, and coat it at a speed of 5-15 m / min and a pressure of 0.4-0.5 MPa, so that the ginger effective substance coating liquid is evenly distributed on the surface of the non-woven fabric; S23 compounding and molding: the double-layer non-woven fabric coated with ginger effective material is compounded by hot pressing method, the coated double-layer compound non-woven fabric is sent into a hot press, the hot pressing temperature is set to 80-150°C, the pressure is set to 0.5-2MPa, and the time is set to 5-30s, and the binder is cured under the action of hot pressing to obtain the preliminarily compounded ginger slices; S24 drying and curing: putting the compounded ginger slices into a drying device and drying them at 45-55°C for 2-4 hours; S25 Cutting and packaging: Use cutting equipment to cut the dried ginger slices into circles with a diameter of 3-5 cm according to the predetermined size, ensure that the edges are neat, and use plastic film bags to heat-seal and package to obtain the finished ginger slices.

7. A moxibustion method containing ginger effective ingredients, characterized in that: The assembly steps specifically include the following operations: S31 Fixing the ginger slices: fixing the ginger slices containing ginger effective substances prepared by the above process on a plastic transparent base using a rubber ring; S32 Install the paper tube: Install the paper tube on the transparent base with the ginger slices fixed; S33: placing the metal sheet and the moxa cake: inserting the metal sheet into the paper tube and placing the moxa cake on the metal sheet; obtaining the assembled moxa containing the effective ingredient of ginger.

8. A moxibustion structure containing ginger effective ingredients, characterized in that: The invention comprises a ginger slice (1), a rubber ring (2), a transparent base (3), a paper tube (4), a metal sheet (5) and a mugwort cake (6); the edge of the ginger slice (1) is fixed on the transparent base (3) by the rubber ring (2); the rubber ring (2) surrounds the ginger slice (1); the transparent base (3) is a sheet-like structure, providing a placement plane for the ginger slice (1); the paper tube (4) has a certain thickness and is made of transparent material; the paper tube (4) is a hollow columnar structure, the bottom of which is installed on the transparent base (3); the paper tube (4) surrounds the area where the ginger slice (1) is located; the metal sheet (5) is The circular thin sheet is placed inside the paper tube (4) and below the ginger sheet (1), and the edge of the metal sheet (5) is in contact with the inner wall of the paper tube (4); the moxa cake (6) is a cylindrical structure and is placed above the metal sheet (5), and the diameter of the moxa cake (6) is smaller than the inner diameter of the paper tube (4); the ginger sheet (1) is connected to the transparent base (3) through the rubber ring (2) to form a combination, the paper tube (4) cooperates with the combination, the metal sheet (5) is placed between the paper tube (4) and the combination, and the moxa cake (6) is located above the metal sheet (5), together forming a complete moxibustion structure.

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